Hras1

Summary

Gene Symbol: Hras1
Description: Harvey rat sarcoma virus oncogene 1
Alias: H-ras, Ha-ras, Harvey-ras, Hras-1, Kras2, c-H-ras, c-Ha-ras, c-rasHa, ras, GTPase HRas, H-Ras-1, H-ras 1 protein, c-Ha-ras p21 protein, c-Ha-ras transgene, p21ras, transforming protein P21
Species: mouse

Top Publications

  1. ncbi Metastasis is driven by sequential elevation of H-ras and Smad2 levels
    Martin Oft
    University of California at San Francisco Comprehensive Cancer Center, Box 0875, San Francisco, California 94143 0875, USA
    Nat Cell Biol 4:487-94. 2002
  2. doi A cross-talk between oncogenic Ras and tumor suppressor PTEN through FAK Tyr861 phosphorylation in NIH/3T3 mouse embryonic fibroblasts
    Young Yil Bahk
    Protein Network Research Center, Yonsei University, 134, Shinchon dong, Seodeamoon Gu, Seoul 120 749, Republic of Korea
    Biochem Biophys Res Commun 377:1199-204. 2008
  3. ncbi Genetic changes in skin tumor progression: correlation between presence of a mutant ras gene and loss of heterozygosity on mouse chromosome 7
    R Bremner
    Beatson Institute for Cancer Research, Bearsden, Glasgow, Scotland
    Cell 61:407-17. 1990
  4. ncbi Involvement of H- and N-Ras isoforms in transforming growth factor-beta1-induced proliferation and in collagen and fibronectin synthesis
    Carlos Martinez-Salgado
    Unidad de Investigacion, Hospital Universitario de Salamanca, Salamanca, Spain
    Exp Cell Res 312:2093-106. 2006
  5. ncbi A critical role for ras-mediated, epidermal growth factor receptor-dependent angiogenesis in mouse skin carcinogenesis
    M Llanos Casanova
    Project on Cell and Molecular Biology and Gene Therapy, Centro de Investigaciones Energeticas, Medioambientales y Tecnologicas, 28040 Madrid, Spain
    Cancer Res 62:3402-7. 2002
  6. ncbi Haplotype sharing suggests that a genomic segment containing six genes accounts for the pulmonary adenoma susceptibility 1 (Pas1) locus activity in mice
    Giacomo Manenti
    Department of Experimental Oncology, Istituto Nazionale Tumori, Milan, Italy
    Oncogene 23:4495-504. 2004
  7. pmc A mouse model for Costello syndrome reveals an Ang II-mediated hypertensive condition
    Alberto J Schuhmacher
    Molecular Oncology Programme, Centro Nacional de Investigaciones Oncologicas, Madrid, Spain
    J Clin Invest 118:2169-79. 2008
  8. ncbi Regulation of long-term potentiation by H-Ras through NMDA receptor phosphorylation
    T Manabe
    Department of Neurophysiology, Faculty of Medicine, University of Tokyo, Tokyo 113 0033, Japan
    J Neurosci 20:2504-11. 2000
  9. pmc K-ras is an essential gene in the mouse with partial functional overlap with N-ras
    L Johnson
    Department of Biology, Massachusetts Institute of Technology, Cambridge 02139, USA
    Genes Dev 11:2468-81. 1997
  10. ncbi 14-3-3 zeta negatively regulates raf-1 activity by interactions with the Raf-1 cysteine-rich domain
    G J Clark
    Department of Pharmacology, Lineberger Comprehensive Cancer Center, University of North Carolina, Chapel Hill, North Carolina 27599, USA
    J Biol Chem 272:20990-3. 1997

Scientific Experts

Detail Information

Publications94

  1. ncbi Metastasis is driven by sequential elevation of H-ras and Smad2 levels
    Martin Oft
    University of California at San Francisco Comprehensive Cancer Center, Box 0875, San Francisco, California 94143 0875, USA
    Nat Cell Biol 4:487-94. 2002
    ..Here we show that during multistage tumorigenesis, discrete expression thresholds of activated Smad2 and H-ras are sequentially surpassed, driving tumour progression through distinct phases from a differentiated squamous ..
  2. doi A cross-talk between oncogenic Ras and tumor suppressor PTEN through FAK Tyr861 phosphorylation in NIH/3T3 mouse embryonic fibroblasts
    Young Yil Bahk
    Protein Network Research Center, Yonsei University, 134, Shinchon dong, Seodeamoon Gu, Seoul 120 749, Republic of Korea
    Biochem Biophys Res Commun 377:1199-204. 2008
    Although Ras is a potent oncogene, its tumorigenicity depends on cellular context and cooperative events...
  3. ncbi Genetic changes in skin tumor progression: correlation between presence of a mutant ras gene and loss of heterozygosity on mouse chromosome 7
    R Bremner
    Beatson Institute for Cancer Research, Bearsden, Glasgow, Scotland
    Cell 61:407-17. 1990
    Initiation of tumorigenesis in mouse skin can be accomplished by mutagenesis of the H-ras gene by treatment with chemical carcinogens...
  4. ncbi Involvement of H- and N-Ras isoforms in transforming growth factor-beta1-induced proliferation and in collagen and fibronectin synthesis
    Carlos Martinez-Salgado
    Unidad de Investigacion, Hospital Universitario de Salamanca, Salamanca, Spain
    Exp Cell Res 312:2093-106. 2006
    ..TGF-beta and Ras signaling pathways are closely related: TGF-beta1 overcomes Ras mitogenic effects and Ras counteracts TGF-beta ..
  5. ncbi A critical role for ras-mediated, epidermal growth factor receptor-dependent angiogenesis in mouse skin carcinogenesis
    M Llanos Casanova
    Project on Cell and Molecular Biology and Gene Therapy, Centro de Investigaciones Energeticas, Medioambientales y Tecnologicas, 28040 Madrid, Spain
    Cancer Res 62:3402-7. 2002
    ..A large body of evidence indicates that in this model, activation of Ha-ras is the critical event in papilloma formation, a process that involves epidermal proliferation and stroma remodeling,..
  6. ncbi Haplotype sharing suggests that a genomic segment containing six genes accounts for the pulmonary adenoma susceptibility 1 (Pas1) locus activity in mice
    Giacomo Manenti
    Department of Experimental Oncology, Istituto Nazionale Tumori, Milan, Italy
    Oncogene 23:4495-504. 2004
    ..with 42 tightly linked markers, including intragenic polymorphisms in five genes (Bcat1, Lrmp, Las1, Ghiso, and Kras2) and amino-acid changes in three genes (Lrmp, Las1, Lmna-rs1)...
  7. pmc A mouse model for Costello syndrome reveals an Ang II-mediated hypertensive condition
    Alberto J Schuhmacher
    Molecular Oncology Programme, Centro Nacional de Investigaciones Oncologicas, Madrid, Spain
    J Clin Invest 118:2169-79. 2008
    Germline activation of H-RAS oncogenes is the primary cause of Costello syndrome (CS), a neuro-cardio-facio-cutaneous developmental syndrome...
  8. ncbi Regulation of long-term potentiation by H-Ras through NMDA receptor phosphorylation
    T Manabe
    Department of Neurophysiology, Faculty of Medicine, University of Tokyo, Tokyo 113 0033, Japan
    J Neurosci 20:2504-11. 2000
    The proto-oncogene ras plays a critical role in cell proliferation and differentiation. However, ras genes are abundantly expressed in the adult CNS, although neuronal cells normally do not proliferate...
  9. pmc K-ras is an essential gene in the mouse with partial functional overlap with N-ras
    L Johnson
    Department of Biology, Massachusetts Institute of Technology, Cambridge 02139, USA
    Genes Dev 11:2468-81. 1997
    Mammalian ras genes are thought to be critical in the regulation of cellular proliferation and differentiation and are mutated in approximately 30% of all human tumors. However, N-ras and H-ras are nonessential for mouse development...
  10. ncbi 14-3-3 zeta negatively regulates raf-1 activity by interactions with the Raf-1 cysteine-rich domain
    G J Clark
    Department of Pharmacology, Lineberger Comprehensive Cancer Center, University of North Carolina, Chapel Hill, North Carolina 27599, USA
    J Biol Chem 272:20990-3. 1997
    Although Raf-1 is a critical effector of Ras signaling and transformation, the mechanism by which Ras promotes Raf-1 activation is complex and remains poorly understood...
  11. pmc NMDA receptor activation dephosphorylates AMPA receptor glutamate receptor 1 subunits at threonine 840
    Jary Y Delgado
    Interdepartmental PhD Program for Neuroscience, University of California, Los Angeles, 90095, USA
    J Neurosci 27:13210-21. 2007
    ..Together, our results show that GluR1 phosphorylation at T840 is regulated by NMDA receptor activation and suggest that decreases in GluR1 phosphorylation at T840 may have a role in LTD...
  12. pmc RGS14 is a novel Rap effector that preferentially regulates the GTPase activity of galphao
    S Traver
    Inserm U 528, Institut Curie Recherche, 26 Rue d Ulm, 75248 Paris Cedex 05, France
    Biochem J 350:19-29. 2000
    In an attempt to elucidate the physiological function(s) of the Ras-related Rap proteins, we used the yeast two-hybrid system and isolated a cDNA encoding a protein that interacts with both Rap1 and Rap2, but not with Ras; the use of ..
  13. pmc Targeted genomic disruption of H-ras and N-ras, individually or in combination, reveals the dispensability of both loci for mouse growth and development
    L M Esteban
    Centro de Investigacion del Cancer, IBMCC, CSIC USAL, University of Salamanca, Salamanca, Spain
    Mol Cell Biol 21:1444-52. 2001
    Mammalian cells harbor three highly homologous and widely expressed members of the ras family (H-ras, N-ras, and K-ras), but it remains unclear whether they play specific or overlapping cellular roles...
  14. ncbi Targeted deletion of the H-ras gene decreases tumor formation in mouse skin carcinogenesis
    K Ise
    Department of Cell Biology, Medical Institute of Bioregulation, Kyushu University, Fukuoka 812 8582, Japan
    Oncogene 19:2951-6. 2000
    To clarify the role of the H-Ras in vivo, we generated H-ras null mutant mice by gene targeting. In spite of the importance of the Ras in cell proliferation and differentiation, H-ras null mutant mice grew normally and were fertile...
  15. ncbi The rat gene map
    C Szpirer
    Curr Top Microbiol Immunol 137:33-8. 1988
  16. pmc Ras subcellular localization defines extracellular signal-regulated kinase 1 and 2 substrate specificity through distinct utilization of scaffold proteins
    Berta Casar
    Departamento de Biologia Molecular, Instituto de Biomedicina y Biotecnología de Cantabria, Consejo Superior de Investigaciones Científicas IDICAN Universidad de Cantabria, Santander, 39011 Cantabria, Spain
    Mol Cell Biol 29:1338-53. 2009
    Subcellular localization influences the nature of Ras/extracellular signal-regulated kinase (ERK) signals by unknown mechanisms...
  17. pmc Transcriptomal profiling of site-specific Ras signals
    Lorena Agudo-Ibáñez
    Instituto de Investigaciones Biomedicas, Consejo Superior de Investigaciones Cientificas CSIC, Departamento de Biologia Molecular, Unidad de Biomedicina, CSIC Universidad de Cantabria, Santander, Spain
    Cell Signal 19:2264-76. 2007
    b>Ras proteins are distributed in distinct plasma-membrane microdomains and endomembranes...
  18. doi Ras signalling regulates differentiation and UCP1 expression in models of brown adipogenesis
    Maria Murholm
    Department of Biomedical Sciences, The Panum Institute, University of Copenhagen, DK 2200 Copenhagen N, Denmark
    Biochim Biophys Acta 1800:619-27. 2010
    The Ras/Raf/MEK/ERK pathway has been recognised as an important signalling module in adipogenesis and adipocyte function, but whether it promotes or inhibits the formation of fat cells has not been reconciled.
  19. ncbi RabGEF1 is a negative regulator of mast cell activation and skin inflammation
    See Ying Tam
    Department of Pathology, Stanford University School of Medicine, Stanford, California 94305, USA
    Nat Immunol 5:844-52. 2004
    ..Here we report that the regulatory protein RabGEF1 bound to Ras and negatively regulated Ras activation and its 'downstream' effector pathways in Fc epsilon RI-dependent mast cell ..
  20. pmc Ecdysone-inducible expression of oncogenic Ha-Ras in NIH 3T3 cells leads to transient nuclear localization of activated extracellular signal-regulated kinase regulated by mitogen-activated protein kinase phosphatase-1
    David Plows
    Institute for Biological Research and Biotechnology, National Hellenic Research Foundation, 116 35 Athens, Greece
    Biochem J 362:305-15. 2002
    The Ras family of GTP-binding proteins are key transducers of extracellular signals, particularly through the mitogen-activated protein kinase (MAPK) pathway...
  21. pmc Serine and tyrosine phosphorylations cooperate in Raf-1, but not B-Raf activation
    C S Mason
    CRC Centre for Cell and Molecular Biology, Institute of Cancer Research, 237 Fulham Road, London SW3 6JB
    EMBO J 18:2137-48. 1999
    ..Expression of Raf-1 with oncogenic Ras gives predominantly S338 phosphorylation, whereas activated Src gives predominantly Y341 phosphorylation...
  22. pmc Dynamic palmitoylation links cytosol-membrane shuttling of acyl-protein thioesterase-1 and acyl-protein thioesterase-2 with that of proto-oncogene H-ras product and growth-associated protein-43
    Eryan Kong
    Section on Developmental Genetics, Program on Developmental Endocrinology and Genetics, Eunice Kennedy Shriver NICHD, National Institutes of Health, Bethesda, MD 20892 1830, USA
    J Biol Chem 288:9112-25. 2013
    ..APT1) and APT2 are cytosolic enzymes that catalyze depalmitoylation of membrane-anchored, palmitoylated H-Ras and growth-associated protein-43 (GAP-43), respectively...
  23. ncbi Reassignment of the H-ras-1 gene to the Hbb-terminus region of mouse chromosome 7
    A B Bianchi
    University of Texas, M D Anderson Cancer Center, Smithville 78957
    Mamm Genome 4:220-2. 1993
  24. pmc Molecular cloning and the total nucleotide sequence of the human c-Ha-ras-1 gene activated in a melanoma from a Japanese patient
    T Sekiya
    Proc Natl Acad Sci U S A 81:4771-5. 1984
    ..patient and maintained in nude mice has been cloned in its biologically active form and identified as the c-Ha-ras-1 gene, a homologue of the viral Ha-ras gene...
  25. ncbi Both (+/-)syn- and (+/-)anti-7,12-dimethylbenz[a]anthracene-3,4-diol-1,2-epoxides initiate tumors in mouse skin that possess -CAA- to -CTA- mutations at Codon 61 of c-H-ras
    M S Tang
    Department of Environmental Medicine, New York University School of Medicine, Tuxedo 10987, USA
    Cancer Res 60:5688-95. 2000
    ..the two metabolically formed bay-region diol epoxides of DMBA, and we have also analyzed mutations in the H-ras gene from tumors induced by these compounds...
  26. ncbi Genetic mapping in human and mouse of the locus encoding TRBP, a protein that binds the TAR region of the human immunodeficiency virus (HIV-1)
    C A Kozak
    Laboratory of Molecular Microbiology, National Institutes of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA
    Genomics 25:66-72. 1995
    ..Western blotting indicates that despite high sequence conservation in human and mouse, the TARBP2 protein differs in apparent size in primate and rodent cells...
  27. pmc Assembly and function of the regulator of G protein signaling 14 (RGS14)·H-Ras signaling complex in live cells are regulated by Gαi1 and Gαi-linked G protein-coupled receptors
    Christopher P Vellano
    Department of Pharmacology, Emory University School of Medicine, Atlanta, Georgia 30322, USA
    J Biol Chem 288:3620-31. 2013
    ..signaling 14 (RGS14) is a multifunctional scaffolding protein that integrates heterotrimeric G protein and H-Ras signaling pathways...
  28. ncbi H-ras up-regulates expression of BNIP3
    Wojciech Kalas
    Department of Experimental Oncology, Ludwik Hirszfeld Institute of Immunology and Experimental Therapy, Polish Academy of Sciences, Wroclaw, Poland
    Anticancer Res 31:2869-75. 2011
    ..Despite the postulated role of BNIP3 in the regulation of survival of cancer cells, the influence of oncogenic transformation on BNIP3 expression is unclear...
  29. ncbi Analysis of p53 tumor suppressor gene, H-ras protooncogene and proliferating cell nuclear antigen (PCNA) in squamous cell carcinomas of HRA/Skh mice following exposure to 8-methoxypsoralen (8-MOP) and UVA radiation (PUVA therapy)
    Luca Lambertini
    Laboratory of Experimental Pathology, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina 27709, USA
    Toxicol Pathol 33:292-9. 2005
    ..In the present study, we evaluated the protein expression of p53 and PCNA and DNA mutations of p53 and H-ras genes in both hyperplastic and neoplastic squamous cell lesions from the NTP study...
  30. pmc p66(Shc) restrains Ras hyperactivation and suppresses metastatic behavior
    Z Ma
    Department of Internal Medicine, Division of Pulmonary and Critical Care, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA
    Oncogene 29:5559-67. 2010
    ..Notably, knockdown of p66(Shc) in normal epithelial cells leads to unrestrained Ras activation, preventing anoikis through downstream suppression of RhoA but blocking proliferation in a pRB-dependent ..
  31. ncbi Effect of Ha-rasval12 on nm23 expression, tumor formation and metastasis of the transformants, and immunomodulation in tumor-bearing mice
    Chang Chi Hsieh
    1Department of Animal Science and Biotechnology, Tunghai University, Taichung, Taiwan, ROC
    Anticancer Res 30:3585-92. 2010
    Overexpression of the Ha-ras(val12) oncogene has frequently been detected in primary and metastatic carcinomas. NM23 is a metastasis inhibition factor and plays a suppressive role in metastasis in many types of cancer...
  32. ncbi Mechanical stress-mediated Runx2 activation is dependent on Ras/ERK1/2 MAPK signaling in osteoblasts
    Takahiro Kanno
    Division of Oral and Maxillofacial Reconstructive Surgery, Department of Oral and Maxillofacial Surgery, Science of Physical Functions, Kyushu Dental College, Fukuoka, Japan
    J Cell Biochem 101:1266-77. 2007
    ..Small interfering RNA (siRNA) targeting Rous sarcoma kinase (RAS), an upstream regulator of both ERK1/2 and p38 MAPKs, inhibited stretch-induced ERK1/2 activation, but not ..
  33. pmc Hyperactivation of Ha-ras oncogene, but not Ink4a/Arf deficiency, triggers bladder tumorigenesis
    Lan Mo
    Department of Urology, New York University Cancer Institute, New York University School of Medicine, New York, New York, USA
    J Clin Invest 117:314-25. 2007
    Although ras is a potent mitogenic oncogene, its tumorigenicity depends on cellular context and cooperative events...
  34. ncbi Identification of PSD-95 palmitoylating enzymes
    Masaki Fukata
    Department of Physiology, University of California at San Francisco, San Francisco, California 94143, USA
    Neuron 44:987-96. 2004
    ..P-PATs) showed substrate specificity, as they did not all enhance palmitoylation of Lck, SNAP-25b, Galpha(s), or H-Ras in cultured cells...
  35. ncbi Math1 target genes are enriched with evolutionarily conserved clustered E-box binding sites
    Valery Krizhanovsky
    Department of Cell and Animal Biology, Institute of Life Sciences, The Hebrew University of Jerusalem, Jerusalem, Israel
    J Mol Neurosci 28:211-29. 2006
    ..enrichment and clustering of MATH1-binding E-boxes only in a subset of differentially expressed genes (Nr2f6, Hras1, and Hes5) in both mouse and man...
  36. ncbi Activated H-Ras regulates hematopoietic cell survival by modulating Survivin
    Seiji Fukuda
    Department of Microbiology and Immunology, Walther Oncology Center, Indiana University School of Medicine, Walther Cancer Institute, Indianapolis, IN 46202, USA
    Biochem Biophys Res Commun 323:636-44. 2004
    Survivin expression and Ras activation are regulated by hematopoietic growth factors...
  37. pmc Requirement of the NF-kappaB subunit p65/RelA for K-Ras-induced lung tumorigenesis
    Daniela S Bassères
    Lineberger Comprehensive Cancer Center and Department of Biology, University of North Carolina, Chapel Hill, North Carolina, USA
    Cancer Res 70:3537-46. 2010
    K-Ras-induced lung cancer is a very common disease, for which there are currently no effective therapies...
  38. doi Oncogenic H-Ras and PI3K signaling can inhibit E-cadherin-dependent apoptosis and promote cell survival after photodynamic therapy in mouse keratinocytes
    Jesus Espada
    Instituto de Investigaciones Biomedicas Alberto Sols, CSIC Departamento de Bioquímica, Facultad de Medicina, Universidad Autonoma de Madrid, Madrid, Spain
    J Cell Physiol 219:84-93. 2009
    ..Here we report that oncogenic activation of H-Ras in murine keratinocytes can prevent cell death induced by immunological disruption of E-cadherin adhesion...
  39. doi Germline expression of H-Ras(G12V) causes neurological deficits associated to Costello syndrome
    J Viosca
    Instituto de Neurociencias de Alicante Universidad Miguel Hernández Consejo Superior de Investigaciones Científicas, Campus de Sant Joan, Apt 18, Sant Joan d Alacant, 03550 Alicante, Spain
    Genes Brain Behav 8:60-71. 2009
    Costello syndrome (CS) is a rare congenital disorder caused by germline activation of H-Ras oncogenes...
  40. pmc Regulator of G-protein signaling 14 (RGS14) is a selective H-Ras effector
    Francis S Willard
    Department of Pharmacology, University of North Carolina, Chapel Hill, North Carolina, United States of America
    PLoS ONE 4:e4884. 2009
    ..RGS14 contains tandem Ras-binding domains that have been reported to bind to Rap- but not Ras GTPases in vitro, leading to the suggestion ..
  41. pmc Angiotensin II-induced activation of c-Ret signaling is critical in ureteric bud branching morphogenesis
    Renfang Song
    Department of Pediatrics, Hypertension and Renal Center of Excellence, Tulane University Health Sciences Center, New Orleans, LA 70112, USA
    Mech Dev 127:21-7. 2010
    The renin-angiotensin system (RAS) plays a critical role in ureteric bud (UB) and kidney morphogenesis...
  42. doi p204 protein is a novel modulator of ras activity
    Bo Ding
    Department of Molecular Biophysics and Biochemistry, Yale University, New Haven, Connecticut 06520 8024, USA
    J Biol Chem 283:5831-48. 2008
    ..A yeast two-hybrid assay revealed a p204-cytoplasmic Ras protein interaction...
  43. pmc Activation of Rho GTPases in Smith-Lemli-Opitz syndrome: pathophysiological and clinical implications
    Xiao Sheng Jiang
    Section on Molecular Dysmorphology, Program in Developmental Endocrinology and Genetics, Eunice Kennedy Shriver National Institute of Child Health, National Institutes of Health, Bethesda, MD 20892, USA
    Hum Mol Genet 19:1347-57. 2010
    ..Developmental abnormalities of neuronal process formation may contribute to the neurocognitive deficits found in SLOS and may represent a potential target for therapeutic intervention...
  44. pmc Very-KIND, a KIND domain containing RasGEF, controls dendrite growth by linking Ras small GTPases and MAP2
    Jinhong Huang
    Laboratory for Molecular Neurogenesis, RIKEN Brain Science Institute, Wako, Saitama 351 0198, Japan
    J Cell Biol 179:539-52. 2007
    ..Here, we report that a brain-specific Ras guanine nucleotide exchange factor (RasGEF) carrying two kinase non-catalytic C-lobe domains (KINDs), very-KIND (v-..
  45. ncbi The RAS-dependent ERF control of cell proliferation and differentiation is mediated by c-Myc repression
    Mihalis Verykokakis
    Medical School, University of Crete and Institute of Molecular Biology and Biotechnology, Foundation for Research and Technology Hellas, Heraklion, Crete, 710 03, Greece
    J Biol Chem 282:30285-94. 2007
    The ERF transcriptional repressor is a downstream effector of the RAS/ERK pathway that interacts with and is directly phosphorylated by ERKs in vivo and in vitro...
  46. pmc Ras-MAPK signaling promotes trophectoderm formation from embryonic stem cells and mouse embryos
    Chi Wei Lu
    Division of Pediatric Hematology and Oncology, Children s Hospital Boston and Dana Faber Cancer Institute, Boston, Massachusetts 02115, USA
    Nat Genet 40:921-6. 2008
    ..Conditional activation of HRas1(Q61L) in ES cells in vitro induces the trophectoderm marker Cdx2 and enables derivation of trophoblast stem (TS) ..
  47. ncbi Cooperation of Ha-ras and Bcl-2 during multistep skin carcinogenesis
    Sangjun Lee
    Department of Hematopathology, The University of Texas M D Anderson Cancer Center, Houston, Texas 77030, USA
    Mol Carcinog 46:949-57. 2007
    ..Deregulation of bcl-2 and ras family members is commonly observed in NMSC...
  48. pmc BLNK binds active H-Ras to promote B cell receptor-mediated capping and ERK activation
    Yasuhiro Imamura
    Division of Molecular Biology, Research Institute for Biological Sciences, Tokyo University of Science, 2669 Yamazaki, Noda, Chiba 278 0022, Japan
    J Biol Chem 284:9804-13. 2009
    Cross-linked B cell receptor (BCR) aggregates on the cell surface, then assembles into the "cap" where Ras is co-localized, and transduces various intracellular signals including Ras-ERK activation...
  49. ncbi Phosphorylation of focal adhesion kinase at tyrosine 861 is crucial for Ras transformation of fibroblasts
    Yangmi Lim
    Department of Life Sciences, Ewha Womans University, Seoul 120 750, Korea
    J Biol Chem 279:29060-5. 2004
    ..FAK phosphorylation at tyrosine 861 was increased in both constitutively H-Ras-transformed and H-Ras-inducible NIH3T3 cells, in parallel with cell transformation...
  50. ncbi Astrocyte-specific expression of activated p21-ras results in malignant astrocytoma formation in a transgenic mouse model of human gliomas
    H Ding
    Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Toronto, Ontario, M5G 1X5 Canada
    Cancer Res 61:3826-36. 2001
    Activation of the p21-ras signaling pathway from aberrantly expressed receptors promotes the growth of malignant human astrocytomas...
  51. ncbi Oncogene-induced liver neoplasia in transgenic mice
    E P Sandgren
    Laboratory of Reproductive Physiology, School of Veterinary Medicine, University of Pennsylvania, Philadelphia 19104
    Oncogene 4:715-24. 1989
    ..of hepatocarcinogenesis were generated by directing the expression of SV40 T-antigens, an oncogenic mutant of c-H-ras, or c-myc to the liver of transgenic mice using the albumin enhancer/promoter...
  52. ncbi Alterations of oncogenes, tumor suppressor genes and growth factors in hepatocellular carcinoma: with relation to tumor size and invasiveness
    Z Tang
    Liver Cancer Institute, Shanghai Medical University, China
    Chin Med J (Engl) 111:313-8. 1998
    ..To make a better understanding of the molecular mechanisms involved in recurrence and metastasis of the hepatocellular carcinoma (HCC), some invasion related oncogenes, and growth factors have been investigated...
  53. ncbi Genetic events and the role of TGF beta in epithelial tumour progression
    R J Akhurst
    Onyx Pharmaceuticals, Richmond, CA 94806, USA
    J Pathol 187:82-90. 1999
    ..The use of transgenic and gene knock-out mice has contributed greatly to knowledge in this area. The H-ras genetic locus has been shown to undergo multiple genetic changes, including mutagenic activation, amplification of ..
  54. ncbi Chromosomal mapping of beta-globin and albino loci in the domestic cat. A conserved mammalian chromosome group
    S J O'Brien
    J Hered 77:374-8. 1986
    ....
  55. ncbi Identification of Nore1 as a potential Ras effector
    D Vavvas
    The Diabetes Unit and Medical Services and the Department of Medicine, Harvard Medical School, Massachusetts General Hospital East, Charlestown, Massachusetts 02129, USA
    J Biol Chem 273:5439-42. 1998
    The small GTP-binding protein Ras is pivotal in transmitting growth and differentiation signals downstream of cell surface receptors...
  56. ncbi Assignment of three rat cellular RAS oncogenes to chromosomes 1, 4, and X
    J Szpirer
    Somat Cell Mol Genet 11:93-7. 1985
    ..hybrids that segregate rat chromosomes were used to determine the chromosomal localization of rat cellular RAS genes...
  57. pmc Chromosome assignments of four mouse cellular homologs of sarcoma and leukemia virus oncogenes
    A Y Sakaguchi
    Proc Natl Acad Sci U S A 81:525-9. 1984
    ..the oncogenes of Rous sarcoma virus (v-src), avian myeloblastosis virus (v-myb), Kirsten murine sarcoma virus (v-Ki-ras), and Harvey murine sarcoma virus (v-Ha-ras) were hybridized to the DNA from mouse-Chinese hamster somatic cell ..
  58. pmc Multiple tumor types appear in a transgenic mouse with the ras oncogene
    R D Cardiff
    Department of Pathology, School of Medicine, University of California, Davis 95616
    Am J Pathol 142:1199-207. 1993
    A transgenic mouse strain with the zeta-globin promoter and the vHa-ras oncogene develops an array of mesenchymal and epithelial neoplasms described here...
  59. ncbi Genetic mapping of three GABAA receptor-subunit genes in the mouse
    M Danciger
    Jules Stein Eye Institute, UCLA School of Medicine
    Genomics 16:361-5. 1993
    ..The Gabrb-1, Gabra-2 pair of genes on Chr 5 maps near the mouse "circling mutation" pi (pirouette)...
  60. pmc Mouse gastric mucin: cloning and chromosomal localization
    L L Shekels
    Department of Medicine, University of Minnesota, Minneapolis 55417, USA
    Biochem J 311:775-85. 1995
    ..Due to sequence similarity and predominant expression in the stomach, the MGM gene may be considered a MUC5AC homologue and named Muc5ac...
  61. ncbi Uroporphyrinogen-III synthase: molecular cloning, nucleotide sequence, expression of a mouse full-length cDNA, and its localization on mouse chromosome 7
    W Xu
    Department of Human Genetics, Mount Sinai School of Medicine, New York, New York 10029 6574, USA
    Genomics 26:556-62. 1995
    ....
  62. ncbi Novel RFLPs at protooncogene and cancer-related gene loci on mouse chromosomes
    J Santos
    Department of Pathology and Kaplan Cancer Center, New York University School of Medicine, NY 10016
    Cytogenet Cell Genet 62:217-9. 1993
    DNA probes for the NRAS, HRAS, KRAS2, LCK, RAF1, MET, MYCL1, MYCN, MYB, ERBB2, FOS, CSF1R, and SRC protooncogene loci; the retinoblastoma gene locus (RB1); the tumor virus integration sites INT2, PVT1, and MLV12; and the locus of the ..
  63. ncbi The protein tyrosine phosphatase epsilon gene maps to mouse chromosome 7 and human chromosome 10q26
    A Elson
    Department of Genetics, Harvard Medical School, Boston, Massachusetts 02115, USA
    Genomics 31:373-5. 1996
    ..Both isoforms have been suggested to arise from a single gene through the use of alternative promoters and 5' exons. The identification of a single PTP epsilon locus in both organisms is consistent with this suggestion...
  64. ncbi Cardiac and skeletal muscle troponin I isoforms are encoded by a dispersed gene family on mouse chromosomes 1 and 7
    J L Guenet
    Institut Pasteur de Paris, Unite de Genetique des Mammiferes, Paris, France
    Mamm Genome 7:13-5. 1996
    ..The cardiac troponin I locus (Tnni3) also mapped to Chr 7, approximately 5-10 cM from the centromere and unlinked to the fast skeletal muscle troponin I locus. Thus, the troponin I gene family is dispersed in the mouse genome...
  65. ncbi G-protein-coupled receptor-mediated activation of rap GTPases: characterization of a novel Galphai regulated pathway
    Jacques T Weissman
    ACADIA Pharmaceuticals Inc, 3911 Sorrento Valley Blvd, San Diego, CA 92121, USA
    Oncogene 23:241-9. 2004
    b>Ras proteins mediate the proliferative effects of G-protein-coupled receptors (GPCRs), but the role of Rap proteins in GPCR signaling is unclear...
  66. ncbi Genetic interaction between the unstable v-Ha-RAS transgene (Tg.AC) and the murine Werner syndrome gene: transgene instability and tumorigenesis
    Aya Leder
    Department of Genetics, Harvard Medical School, Howard Hughes Medical Institute, 200 Longwood Ave, Boston, Massachusetts, MA 02115, USA
    Oncogene 21:6657-68. 2002
    ..AC transgene (consisting of v-Ha-Ras driven by an embryonic zeta-globin promoter) would not ordinarily be expected to develop skin and other adult ..
  67. ncbi Sodium arsenite administration via drinking water increases genome-wide and Ha-ras DNA hypomethylation in methyl-deficient C57BL/6J mice
    R S Okoji
    Center for Occupational and Environmental Health, UCLA School of Public Health, 650 Charles E Young Drive South, Los Angeles, CA 90095, USA
    Carcinogenesis 23:777-85. 2002
    ..the role of a methyl-deficient diet in combination with sodium arsenite on the genomic methylation status and Ha-ras methylation status of C57BL/6J male mice hepatic DNA...
  68. ncbi The structural gene for the M1 subunit of ribonucleotide reductase maps to chromosome 11, band p15, in human and to chromosome 7 in mouse
    J E Brissenden
    Department of Human Genetics, Yale University School of Medicine, New Haven, Connecticut 06510
    Exp Cell Res 174:302-8. 1988
    ..4----p15.5. The mouse Rrml locus was assigned to chromosome 7, where it forms part of a conserved syntenic group of at least seven other genes assigned to human chromosome band 11p15...
  69. ncbi The rasH2 transgenic mouse: nature of the model and mechanistic studies on tumorigenesis
    N Tamaoki
    Tokai University School of Medicine, Central Institute for Experimental Animals, Miyamae, Kawasaki, Japan
    Toxicol Pathol 29:81-9. 2001
    The rasH2 mouse is a hemizygous transgenic mouse carrying the c-Ha-ras oncogene and that gene's promotor/enhancer within the genetic background of a BALB/cByJ x C57BL/6J F1 mouse...
  70. ncbi The Tg.AC (v-Ha-ras) transgenic mouse: nature of the model
    R W Tennant
    National Institute of Environmental Health Sciences, Laboratory of Environmental Carcinogenesis and Mutagenesis, Research Triangle Park, North Carolina 27709, USA
    Toxicol Pathol 29:51-9. 2001
    The Tg.AC (v-Ha-ras) transgenic mouse model provides a reporter phenotype of skin papillomas in response to either genotoxic or nongenotoxic carcinogens. In common with the conventional bioassay, the Tg...
  71. ncbi Chromosomal localization of the rat Harvey-ras-1 gene (HRAS) by in situ hybridization
    L S Gollahon
    Department of Carcinogenesis, University of Texas M D Anderson Cancer Center, Smithville 78957
    Cytogenet Cell Genet 61:123-4. 1992
    The rat Harvey-ras-1 protooncogene (HRAS) has previously been assigned to rat chromosome 1. In this study we further refine its localization to region 1q41-->q42 through the use of fluorescent in situ hybridization.
  72. pmc Ha-ras oncogene expression directed by a milk protein gene promoter: tissue specificity, hormonal regulation, and tumor induction in transgenic mice
    A C Andres
    Proc Natl Acad Sci U S A 84:1299-303. 1987
    The activated human Ha-ras oncogene was subjected to the control of the promoter region of the murine whey acidic protein (Wap) gene, which is expressed in mammary epithelial cells in response to lactogenic hormones...
  73. ncbi Cellular proto-oncogene expression following exposure of mice to gamma rays
    A Anderson
    Argonne National Laboratory, Biological and Medical Research Division, Illinois 60439 4833
    Radiat Res 130:340-4. 1992
    ..We selected specific cellular oncogenes (c-fos, c-myc, c-src, and c-H-ras), based on their normal expression in liver and gut tissues from untreated mice...
  74. pmc Transgenic oncogene mice. Tumor phenotype predicts genotype
    R D Cardiff
    Department of Pathology, School of Medicine, University of California, Davis 95616
    Am J Pathol 139:495-501. 1991
    ..tumor phenotype was tested by examining slides from 607 mammary tumors from 407 transgenic mice bearing the ras, myc, and/or neu oncogenes...
  75. doi Regulation and function of neuronal GTP-Ras in facial motor nerve regeneration
    Milan Makwana
    Perinatal Brain Repair Group, Department of Obstetrics and Gynaecology, EGA Institute of Women s Health, University College London, London, UK
    J Neurochem 108:1453-63. 2009
    Activation of Ras into the GTP-binding, 'ON' state is a key switch in the neurotrophin-mediated neuronal survival and neurite outgrowth, in vitro as well as in vivo...
  76. doi Constitutively enhanced p21Ras activity amplifies dendritic remodeling of hippocampal neurons during physical activity
    Alan Alpar
    Department of Anatomy, Histology and Embryology, Semmelweis University Medical School, Tuzolto u 58, H 1450 Budapest, Hungary
    Int J Dev Neurosci 27:407-11. 2009
    In the present study we show that overexpression of constitutively active Ras amplifies the dendritic remodeling observed when animals were allowed to be physically active...
  77. pmc H-ras expression in immortalized keratinocytes produces an invasive epithelium in cultured skin equivalents
    Melville B Vaughan
    Department of Cell Biology, University of Texas Southwestern Medical Center, Dallas, Texas, United States of America
    PLoS ONE 4:e7908. 2009
    b>Ras proteins affect both proliferation and expression of collagen-degrading enzymes, two important processes in cancer progression...
  78. ncbi Adhesion-related kinase induction of migration requires phosphatidylinositol-3-kinase and ras stimulation of rac activity in immortalized gonadotropin-releasing hormone neuronal cells
    Sheila M Nielsen-Preiss
    Department of Medicine, The University of Colorado at Denver, Denver, CO 80220, USA
    Endocrinology 148:2806-14. 2007
    ..Exogenous expression of a dominant-negative form of Ras also decreased GnRH neuronal lamellipodia formation, migration, and Rac activation...
  79. ncbi Small GTPases and cell cycle regulation
    C J Marshall
    CRC Centre for Cell and Molecular Biology, Institute of Cancer Research, London, UK
    Biochem Soc Trans 27:363-70. 1999
  80. ncbi Effects of dietary calorie restriction or exercise on the PI3K and Ras signaling pathways in the skin of mice
    Linglin Xie
    Department of Human Nutrition and Statistics, Kansas State University, Manhattan, Kansas 66506, USA
    J Biol Chem 282:28025-35. 2007
    ..the effects of weight loss by increasing physical activity or decreasing calorie intake on tumor promoter-induced Ras-MAPK and PI3K-Akt pathways...
  81. ncbi Combined subcarcinogenic benzo[a]pyrene and UVA synergistically caused high tumor incidence and mutations in H-ras gene, but not p53, in SKH-1 hairless mouse skin
    Yongyin Wang
    Department of Dermatology, Mount Sinai School of Medicine, New York, NY 10029, USA
    Int J Cancer 116:193-9. 2005
    Combined subcarcinogenic doses of benzo[a]pyrene (BaP) and UVA induced H-ras, but not p53, gene mutations 8 weeks before tumor emergence in SKH-1 mice...
  82. pmc Induction of murine CD5 expression by v-H-ras
    T R Weichert
    Department of Microbiology, Michigan State University, East Lansing 48824 1101, USA
    Immunology 90:30-7. 1997
    ..is a frequent marker on B-lineage cell lines produced from bone marrow infected with retroviruses expressing v-H-ras. Since CD5+ B cells cannot be detected in adult murine bone marrow, either the viral targets of transformation are ..
  83. ncbi Localization of growth arrest-specific genes on mouse chromosomes 1, 7, 8, 11, 13, and 16
    M P Colombo
    Division of Experimental Oncology D, Istituto Nazionali Tumori, Milano, Italy
    Mamm Genome 2:130-4. 1992
    ..The six genes are unlinked. Gas-1 maps to Chromosome (Chr) 13, Gas-2 to Chr 7, Gas-3 to Chr 11, Gas-4 to Chr 16, Gas-6 to Chr 8, and Gas-10 to Chr 1...
  84. ncbi Diversity, parental germline origin, and phenotypic spectrum of de novo HRAS missense changes in Costello syndrome
    Giuseppe Zampino
    Istituto di Clinica Pediatrica, Universita Cattolica del Sacro Cuore, Rome, Italy
    Hum Mutat 28:265-72. 2007
    Activating mutations in v-Ha-ras Harvey rat sarcoma viral oncogene homolog (HRAS) have recently been identified as the molecular cause underlying Costello syndrome (CS)...
  85. ncbi Alternative splicing of the human proto-oncogene c-H-ras renders a new Ras family protein that trafficks to cytoplasm and nucleus
    Sonia Guil
    Centre d Investigació Cardiovascular Consejo Superior de Investigaciones Científicas, Barcelona, Spain
    Cancer Res 63:5178-87. 2003
    We characterized a novel protein of the Ras family, p19 (H-RasIDX). The c-H-ras proto-oncogene undergoes alternative splicing of the exon termed IDX...
  86. ncbi Activating transcription factor 3, a stress-inducible gene, suppresses Ras-stimulated tumorigenesis
    Dan Lu
    Ohio State Biochemistry Program, Department of Molecular and Cellular Biochemistry and Center for Molecular Neurobiology, Ohio State University, Columbus, OH 43210, USA
    J Biol Chem 281:10473-81. 2006
    ..Consistent with the growth arrest and pro-apoptotic roles of ATF3, ATF3(-) fibroblasts upon Ras transformation exhibited higher growth rate, produced more colonies in soft agar, and formed larger tumor upon ..
  87. ncbi Susceptibilities of p53 knockout and rasH2 transgenic mice to urethane-induced lung carcinogenesis are inherited from their original strains
    Masakazu Ozaki
    Department of Experimental Pathology and Tumor Biology, Nagoya City University, Graduate School of Medical Sciences, Mizuho ku, Nagoya 467 8601, Japan
    Toxicol Pathol 33:267-71. 2005
    In the present study, susceptibility of CB6F1 mice carrying the human prototype c-Ha-ras gene (rasH2 mice) and p53 gene knockout mice (p53 (+/-) mice) to urethane-induced lung carcinogenesis was compared under the same experimental ..
  88. ncbi Pure lipopolysaccharide or synthetic lipid A induces activation of p21Ras in primary macrophages through a pathway dependent on Src family kinases and PI3K
    Muriel D David
    Biomedical Research Centre, University of British Columbia, Vancouver, British Columbia, Canada
    J Immunol 175:8236-41. 2005
    ..activation of multiple signaling pathways in macrophages, it was unclear whether these include activation of the p21Ras GTPases...
  89. ncbi Isolation and characterization of the 5' flanking region of the mouse c-Harvey-ras gene
    K Brown
    Beatson Institute for Cancer Research, Glasgow, Scotland
    Mol Carcinog 1:161-70. 1988
    The complete 5' flanking region of the murine c-Ha-ras gene was cloned and sequenced. An untranslated exon (-1) was identified and the promoter region of the gene located...
  90. pmc The p53-dependent effects of macrophage migration inhibitory factor revealed by gene targeting
    G Fingerle-Rowson
    The Picower Institute for Medical Research, Manhasset, NY 11030, USA
    Proc Natl Acad Sci U S A 100:9354-9. 2003
    ..MIF-KO mice exhibit p53-dependent growth alterations, increased p53 transcriptional activity, and resistance to ras-mediated transformation...
  91. pmc Pak1 regulates multiple c-Kit mediated Ras-MAPK gain-in-function phenotypes in Nf1+/- mast cells
    ANDREW S MCDANIEL
    Department of Microbiology and Immunology, Herman B Wells Center for Pediatric Research, Indiana University School of Medicine, Indianapolis 46202, USA
    Blood 112:4646-54. 2008
    ..common genetic disorder caused by mutations in the NF1 locus, which encodes neurofibromin, a negative regulator of Ras. Patients with NF1 develop numerous neurofibromas, which contain many inflammatory mast cells that contribute to ..
  92. pmc Ancestral bias in the Hras1 gene and distal Chromosome 7 among inbred mice
    Jennifer C Drew
    McArdle Laboratory for Cancer Research, University of Wisconsin School of Medicine and Public Health, 1400 University Avenue, Madison, Wisconsin 53706, USA
    Mamm Genome 18:732-8. 2007
    Inbred strains of mice vary in their frequency of liver tumors initiated by a mutation in the Hras1 (H-ras) proto-oncogene. We sequenced 4...
  93. doi Enhanced Ras activity preserves dendritic size and extension as well as synaptic contacts of neurons after functional deprivation in synRas mice
    A Alpar
    Department of Anatomy, Histology and Embryology, Semmelweis University Medical School, Tuzolto u 58, H 1450 Budapest, Hungary
    Eur J Neurosci 27:3083-94. 2008
    The monomeric GTP-binding protein p21Ras has been repeatedly implicated in neuronal stability and plastic changes of the adult nervous system...
  94. pmc H-ras regulates angiogenesis and vascular permeability by activation of distinct downstream effectors
    Doinita Serban
    Moores Cancer Center, University of California San Diego, La Jolla, CA 92093, USA
    Circ Res 102:1350-8. 2008
    ..Downstream mechanisms that define these vascular responses remain unknown. H-Ras activation has been associated with the angiogenic response...

Research Grants21

  1. Mouse Model of Pancreatic Cancer Progression-Maintenance
    Nabeel Bardeesy; Fiscal Year: 2007
    ..An important component of my program will be my continued participation in a multidisciplinary consortium of pancreatic cancer researchers currently in the process of addressing a series of programmatic initiatives. ..
  2. Ras & PI 3-Kinase Signaling in Lens Development
    Lixing Reneker; Fiscal Year: 2006
    ..cell types, a growth factor binding its receptor will trigger the receptor tyrosine kinase activity which activates Ras, a small GTP-binding protein...
  3. Analysis and Identification of Skin Cancer in Mice
    Hiroki Nagase; Fiscal Year: 2007
    ..In the long term, understanding the genetic load which leads to cancer susceptibility in the human population will provide rational alternatives to cancer prevention, screening and risk assessment. ..
  4. Ras and Phosphoinositide 3-kinase Signaling in Lens Development
    Lixing Reneker; Fiscal Year: 2009
    ..b>Ras is a small GTP-binding protein downstream of growth factor receptor tyrosine kinases (RTKs) and plays a critical ..
  5. Ras and Phosphoinositide 3-kinase Signaling in Lens Development
    Lixing W Reneker; Fiscal Year: 2010
    ..b>Ras is a small GTP-binding protein downstream of growth factor receptor tyrosine kinases (RTKs) and plays a critical ..
  6. Lipid peroxidation product induced DNA damage in the p53 gene and liver cancer
    ERIC MOON SHONG TANG; Fiscal Year: 2006
    ..In addition, we will determine the effect of stereostructure of 4-HNE-dG at GAGGC sites on repair and mutagenicity. Results from these studies should greatly enhance our understanding of the role of LPO in hepatocarcinogenesis. ..
  7. Cell type gene delivery and alcoholic liver disease
    Michael Wheeler; Fiscal Year: 2006
    ..In addition, through didactic training, and interactions with his mentor and key faculty, the applicant will acquire new skills that will allow him to become a successful member of the alcohol research community. ..
  8. Acute Ethanol-Induced Innate Immune Response in Liver
    Michael Wheeler; Fiscal Year: 2005
    ..The aims below will use gene delivery techniques and knockout mouse technology to address these critical questions related to roles of LPS, PI3 kinase activation, and CD14 expression in both acute ethanol and chronic ethanol toxicity. ..
  9. Ras and Phosphoinositide 3-kinase Signaling in Lens Development
    Lixing W Reneker; Fiscal Year: 2011
    ..b>Ras is a small GTP-binding protein downstream of growth factor receptor tyrosine kinases (RTKs) and plays a critical ..