Gene Symbol: Hprt
Description: hypoxanthine guanine phosphoribosyl transferase
Alias: C81579, HPGRT, Hprt1, hypoxanthine-guanine phosphoribosyltransferase, HGPRT, HGPRTase, HPRT B, hypoxanthine guanine phosphoribosyl transferase 1
Species: mouse
Products:     Hprt

Top Publications

  1. Visser J, Smith D, Moy S, Breese G, Friedmann T, Rothstein J, et al. Oxidative stress and dopamine deficiency in a genetic mouse model of Lesch-Nyhan disease. Brain Res Dev Brain Res. 2002;133:127-39 pubmed
  2. Tang S, Silva F, Tsark W, Mann J. A Cre/loxP-deleter transgenic line in mouse strain 129S1/SvImJ. Genesis. 2002;32:199-202 pubmed
    A Cre recombinase expression cassette was inserted into the X-linked Hprt locus by gene targeting in a mouse embryonic stem (ES) cell line isogenic to strain 129S1/SvImJ (129S1), then the transgene was introduced into 129S1 mice through ..
  3. Ma X, Kiraly D, Gaier E, Wang Y, Kim E, Levine E, et al. Kalirin-7 is required for synaptic structure and function. J Neurosci. 2008;28:12368-82 pubmed publisher
    ..Expression of exogenous Kal7 in Kal7(KO) neurons rescued this deficit. Kal7 plays an essential role in synaptic structure and function, affecting a subset of cognitive processes. ..
  4. Jinnah H, Gage F, Friedmann T. Animal models of Lesch-Nyhan syndrome. Brain Res Bull. 1990;25:467-75 pubmed
    In humans, deficiency of the enzyme hypoxanthine-guanine phosphoribosyltransferase (HPRT) is associated with a disorder known as Lesch-Nyhan syndrome which includes severe neurobehavioral abnormalities...
  5. Marinić M, Aktas T, Ruf S, Spitz F. An integrated holo-enhancer unit defines tissue and gene specificity of the Fgf8 regulatory landscape. Dev Cell. 2013;24:530-42 pubmed publisher
    ..We discuss the implications of such regulatory systems regarding the evolution of gene expression and the impact of human genomic structural variations. ..
  6. Tilstra J, Robinson A, Wang J, Gregg S, Clauson C, Reay D, et al. NF-?B inhibition delays DNA damage-induced senescence and aging in mice. J Clin Invest. 2012;122:2601-12 pubmed publisher
    ..IKK/NF-?B inhibitors are sufficient to attenuate this damage and could provide clinical benefit for degenerative changes associated with accelerated aging disorders and normal aging. ..
  7. Palais G, Nguyen Dinh Cat A, Friedman H, Panek Huet N, Millet A, Tronche F, et al. Targeted transgenesis at the HPRT locus: an efficient strategy to achieve tightly controlled in vivo conditional expression with the tet system. Physiol Genomics. 2009;37:140-6 pubmed publisher
    ..stem (ES) cell line supporting efficient germ-line transmission, we used hypoxanthine phosphoribosyltransferase (HPRT) targeting to insert a single copy tet-inducible construct designed to allow both glucocorticoid receptor (GR) and ..
  8. Luchman H, Friedman H, Villemaire M, Peterson A, Jirik F. Temporally controlled prostate epithelium-specific gene alterations. Genesis. 2008;46:229-34 pubmed publisher
    Employing the Hprt locus as the site for targeted transgenesis we have developed mice expressing the tamoxifen-inducible Cre-ER(T2) fusion protein under the control of the ARR2-rat probasin promoter...
  9. Karrasch T, Kim J, Muhlbauer M, Magness S, Jobin C. Gnotobiotic IL-10-/-;NF-kappa B(EGFP) mice reveal the critical role of TLR/NF-kappa B signaling in commensal bacteria-induced colitis. J Immunol. 2007;178:6522-32 pubmed
    ..Blocking TLR-induced NF-kappaB activity may represent an attractive strategy to treat immune-mediated intestinal inflammation. ..

More Information


  1. Cadieux C, Fournier S, Peterson A, Bédard C, Bedell B, Nepveu A. Transgenic mice expressing the p75 CCAAT-displacement protein/Cut homeobox isoform develop a myeloproliferative disease-like myeloid leukemia. Cancer Res. 2006;66:9492-501 pubmed
    ..The transgene was introduced into the hprt locus of 129/Ola embryonic stem cells and, following germ line passage, was backcrossed onto the FVB and C57BL/6 ..
  2. Cvetkovic B, Yang B, Williamson R, Sigmund C. Appropriate tissue- and cell-specific expression of a single copy human angiotensinogen transgene specifically targeted upstream of the HPRT locus by homologous recombination. J Biol Chem. 2000;275:1073-8 pubmed
    ..angiotensinogen transgenic mouse model generated by targeting the human angiotensinogen gene upstream of the mouse HPRT locus by homologous recombination...
  3. Finger S, Heavens R, Sirinathsinghji D, Kuehn M, Dunnett S. Behavioral and neurochemical evaluation of a transgenic mouse model of Lesch-Nyhan syndrome. J Neurol Sci. 1988;86:203-13 pubmed
    Two transgenic strains of mutant mice lacking hypoxanthine-guanidine phosphoribosyltransferase (HPRT) activity were examined behaviorally and neurochemically for phenotypic similarity to the human Lesch-Nyhan syndrome...
  4. Wu S, Ying G, Wu Q, Capecchi M. Toward simpler and faster genome-wide mutagenesis in mice. Nat Genet. 2007;39:922-30 pubmed
  5. Rankin E, Tomaszewski J, Haase V. Renal cyst development in mice with conditional inactivation of the von Hippel-Lindau tumor suppressor. Cancer Res. 2006;66:2576-83 pubmed
  6. Kuehn M, Bradley A, Robertson E, Evans M. A potential animal model for Lesch-Nyhan syndrome through introduction of HPRT mutations into mice. Nature. 1987;326:295-8 pubmed
    ..deficiency in the level of activity of the purine salvage enzyme hypoxanthine-guanosine phosphoribosyl transferase (HPRT)...
  7. Vernet N, Mahadevaiah S, Ojarikre O, Longepied G, Prosser H, Bradley A, et al. The Y-encoded gene zfy2 acts to remove cells with unpaired chromosomes at the first meiotic metaphase in male mice. Curr Biol. 2011;21:787-93 pubmed publisher
    ..These findings provide further insight into the basis for the much lower transmission of chromosomal errors originating at the first meiotic division in men than in women [7]...
  8. Minami T, Donovan D, Tsai J, Rosenberg R, Aird W. Differential regulation of the von Willebrand factor and Flt-1 promoters in the endothelium of hypoxanthine phosphoribosyltransferase-targeted mice. Blood. 2002;100:4019-25 pubmed
    ..of 2 different genes, namely von Willebrand factor (VWF) and Flt-1, to the hypoxanthine phosphoribosyltransferase (Hprt) gene locus...
  9. Montavon T, Soshnikova N, Mascrez B, Joye E, Thevenet L, Splinter E, et al. A regulatory archipelago controls Hox genes transcription in digits. Cell. 2011;147:1132-45 pubmed publisher
  10. Bartholin L, Cyprian F, Vincent D, Garcia C, Martel S, Horvat B, et al. Generation of mice with conditionally activated transforming growth factor beta signaling through the TbetaRI/ALK5 receptor. Genesis. 2008;46:724-31 pubmed publisher
    ..TbetaRI/ALK5) by using a knock-in strategy into the X chromosome-linked hypoxanthine phosphoribosyl-transferase (Hprt) locus...
  11. Muzumdar M, Luo L, Zong H. Modeling sporadic loss of heterozygosity in mice by using mosaic analysis with double markers (MADM). Proc Natl Acad Sci U S A. 2007;104:4495-500 pubmed
    ..These studies establish MADM as a high-resolution method for modeling sporadic loss of heterozygosity in mice, providing insights into TSG function. ..
  12. Schmouth J, Banks K, Mathelier A, Gregory Evans C, Castellarin M, Holt R, et al. Retina restored and brain abnormalities ameliorated by single-copy knock-in of human NR2E1 in null mice. Mol Cell Biol. 2012;32:1296-311 pubmed publisher
    ..This is the first time a separation of regulatory mechanisms governing NR2E1 has been demonstrated. Furthermore, candidate genomic regions controlling expression in proliferating cells during neurogenesis were identified. ..
  13. Blewitt M, Gendrel A, Pang Z, Sparrow D, Whitelaw N, Craig J, et al. SmcHD1, containing a structural-maintenance-of-chromosomes hinge domain, has a critical role in X inactivation. Nat Genet. 2008;40:663-9 pubmed publisher
    ..MommeD1 shows homozygous female-specific mid-gestation lethality and hypomethylation of the X-linked gene Hprt1, suggestive of a defect in X inactivation...
  14. Zong H, Espinosa J, Su H, Muzumdar M, Luo L. Mosaic analysis with double markers in mice. Cell. 2005;121:479-92 pubmed
    ..To illustrate the utility of MADM, we show that cerebellar granule cell progenitors are fated at an early stage to produce granule cells with axonal projections limited to specific sublayers of the cerebellar cortex. ..
  15. Magness S, Jijon H, Van Houten Fisher N, Sharpless N, Brenner D, Jobin C. In vivo pattern of lipopolysaccharide and anti-CD3-induced NF-kappa B activation using a novel gene-targeted enhanced GFP reporter gene mouse. J Immunol. 2004;173:1561-70 pubmed
    ..In summary, the cis-NF-kappa B(EGFP) mouse will serve as a valuable tool to address multiple questions regarding the cell-specific and real-time activation of NF-kappa B during normal and diseased states. ..
  16. Guibinga G, Murray F, Barron N, Pandori W, Hrustanovic G. Deficiency of the purine metabolic gene HPRT dysregulates microRNA-17 family cluster and guanine-based cellular functions: a role for EPAC in Lesch-Nyhan syndrome. Hum Mol Genet. 2013;22:4502-15 pubmed publisher
    ..by mutations in the gene encoding the purine metabolic enzyme hypoxanthine-guanine phosphoribosyltransferase (HPRT)...
  17. Zheng B, Mills A, Bradley A. A system for rapid generation of coat color-tagged knockouts and defined chromosomal rearrangements in mice. Nucleic Acids Res. 1999;27:2354-60 pubmed
    ..By incorporating mouse coat color markers into the vectors, we illustrate a widely applicable method for stock maintenance of ES cell-derived mice with single gene knockouts or more extensive chromosomal rearrangements. ..
  18. Cadieux C, Kedinger V, Yao L, Vadnais C, Drossos M, Paquet M, et al. Mouse mammary tumor virus p75 and p110 CUX1 transgenic mice develop mammary tumors of various histologic types. Cancer Res. 2009;69:7188-97 pubmed publisher
    ..of these short CUX1 isoforms in driving mammary tumor development, we used site-specific transgenesis into the Hprt locus to generate transgenic mice expressing p75 or p110 CUX1 under the control of the mouse mammary tumor virus-..
  19. Engle S, Womer D, Davies P, Boivin G, Sahota A, Simmonds H, et al. HPRT-APRT-deficient mice are not a model for lesch-nyhan syndrome. Hum Mol Genet. 1996;5:1607-10 pubmed
    Complete hypoxanthine-guanine phosphoribosyl-transferase (HPRT) deficiency in humans results in the Lesch-Nyhan syndrome which is characterized, among other features, by compulsive self-injurious behavior...
  20. Yang G, Banks K, Bonaguro R, Wilson G, Dreolini L, de Leeuw C, et al. Next generation tools for high-throughput promoter and expression analysis employing single-copy knock-ins at the Hprt1 locus. Genomics. 2009;93:196-204 pubmed publisher
    ..engineered a set of useful tools that facilitate targeted single copy knock-in (KI) at the hypoxanthine guanine phosphoribosyl transferase 1 (Hprt1) locus...
  21. Thorel F, Nepote V, Avril I, Kohno K, Desgraz R, Chera S, et al. Conversion of adult pancreatic alpha-cells to beta-cells after extreme beta-cell loss. Nature. 2010;464:1149-54 pubmed publisher
    ..Such inter-endocrine spontaneous adult cell conversion could be harnessed towards methods of producing beta-cells for diabetes therapies, either in differentiation settings in vitro or in induced regeneration. ..
  22. Welsh M, Saunders P, Atanassova N, Sharpe R, Smith L. Androgen action via testicular peritubular myoid cells is essential for male fertility. FASEB J. 2009;23:4218-30 pubmed publisher
  23. Prosser H, Rzadzinska A, Steel K, Bradley A. Mosaic complementation demonstrates a regulatory role for myosin VIIa in actin dynamics of stereocilia. Mol Cell Biol. 2008;28:1702-12 pubmed
    ..Our results strongly suggest that myosin VIIa regulates the establishment of a setpoint for stereocilium heights, and this novel role may influence their normal staircase-like arrangement within a bundle. ..
  24. Mikolaenko I, Rao L, Roberts R, Kolb B, Jinnah H. A Golgi study of neuronal architecture in a genetic mouse model for Lesch-Nyhan disease. Neurobiol Dis. 2005;20:479-90 pubmed
    ..LND) is an inherited disorder associated with deficiency of hypoxanthine-guanine phosphoribosyltransferase (HPRT), an enzyme essential for purine recycling...
  25. Tang M, Jacobs S, Wong L, Mann J. Conditional allelic replacement applied to genes encoding the histone variant H3.3 in the mouse. Genesis. 2013;51:142-6 pubmed publisher
    ..3 protein. Such vectors will allow for the conditional substitution of specific residues in order to dissect the roles of H3.3 post-translational modifications in development and disease. ..
  26. Andrey G, Montavon T, Mascrez B, Gonzalez F, Noordermeer D, Leleu M, et al. A switch between topological domains underlies HoxD genes collinearity in mouse limbs. Science. 2013;340:1234167 pubmed publisher
    ..This regulatory strategy accounts for collinear Hox gene regulation in land vertebrate appendages. ..
  27. Imrie H, Viswambharan H, Sukumar P, Abbas A, Cubbon R, Yuldasheva N, et al. Novel role of the IGF-1 receptor in endothelial function and repair: studies in endothelium-targeted IGF-1 receptor transgenic mice. Diabetes. 2012;61:2359-68 pubmed publisher
    ..The IGF-1R, although reducing NO bioavailability, enhances in situ endothelium regeneration. Manipulating IGF-1R in the endothelium may be a useful strategy to treat disorders of vascular growth and repair. ..
  28. Jinnah H, Wojcik B, Hunt M, Narang N, Lee K, Goldstein M, et al. Dopamine deficiency in a genetic mouse model of Lesch-Nyhan disease. J Neurosci. 1994;14:1164-75 pubmed
    ..a deletion mutation in the gene encoding the purine salvage enzyme hypoxanthine-guanine phosphoribosyltransferase (HPRT)...
  29. Szabo P, Han L, Hyo Jung J, Mann J. Mutagenesis in mice of nuclear hormone receptor binding sites in the Igf2/H19 imprinting control region. Cytogenet Genome Res. 2006;113:238-46 pubmed
    ..No effect was obtained--in the female and male germ lines the mutant ICR remained hypomethylated and hypermethylated, respectively. The ICR imprinting mechanism remains undefined. ..
  30. Heaney J, Rettew A, Bronson S. Tissue-specific expression of a BAC transgene targeted to the Hprt locus in mouse embryonic stem cells. Genomics. 2004;83:1072-82 pubmed
    The hypoxanthine phosphoribosyltransferase (Hprt) locus has been shown to have minimal influence on transgene expression when used as a surrogate site in the mouse genome...
  31. Pacifico R, Dewan A, Cawley D, Guo C, Bozza T. An olfactory subsystem that mediates high-sensitivity detection of volatile amines. Cell Rep. 2012;2:76-88 pubmed publisher
    ..Our data uncover a hard-wired, parallel input stream in the main olfactory pathway that is specialized for the detection of volatile amines...
  32. Su H, Mills A, Wang X, Bradley A. A targeted X-linked CMV-Cre line. Genesis. 2002;32:187-8 pubmed
  33. Royo H, Polikiewicz G, Mahadevaiah S, Prosser H, Mitchell M, Bradley A, et al. Evidence that meiotic sex chromosome inactivation is essential for male fertility. Curr Biol. 2010;20:2117-23 pubmed publisher
    ..Our findings show that MSCI is essential for male meiosis and, as such, provide insight into the differential severity of meiotic mutations' effects on male and female meiosis. ..
  34. Guillot P, Liu L, Kuivenhoven J, Guan J, Rosenberg R, Aird W. Targeting of human eNOS promoter to the Hprt locus of mice leads to tissue-restricted transgene expression. Physiol Genomics. 2000;2:77-83 pubmed
    ..synthase (eNOS) promoter coupled to the LacZ reporter gene to the X-linked hypoxanthine phosphoribosyltransferase (Hprt) locus of mice by homologous recombination...
  35. Wei Q, Bhatt K, He H, Mi Q, Haase V, Dong Z. Targeted deletion of Dicer from proximal tubules protects against renal ischemia-reperfusion injury. J Am Soc Nephrol. 2010;21:756-61 pubmed publisher
    ..Microarray analysis showed altered expression of specific microRNAs during renal IRI. Taken together, these results demonstrate evidence for a pathogenic role of Dicer and associated microRNAs in renal IRI. ..
  36. Thompson S, Clarke A, Pow A, Hooper M, Melton D. Germ line transmission and expression of a corrected HPRT gene produced by gene targeting in embryonic stem cells. Cell. 1989;56:313-21 pubmed
    The deletion mutation in the HPRT-deficient mouse embryonic stem (ES) cell line E14TG2a has been corrected by gene targeting. The presence of plasmid sequences in the correcting vector DNA did not affect the frequency of correction...
  37. Nijnik A, Clare S, Hale C, Chen J, Raisen C, Mottram L, et al. The role of sphingosine-1-phosphate transporter Spns2 in immune system function. J Immunol. 2012;189:102-11 pubmed publisher
    ..Other components of the S1P signaling network are investigated as drug targets for immunosuppressive therapy, but the selective action of Spns2 may present an advantage in this regard. ..
  38. Montavon T, Thevenet L, Duboule D. Impact of copy number variations (CNVs) on long-range gene regulation at the HoxD locus. Proc Natl Acad Sci U S A. 2012;109:20204-11 pubmed publisher
    ..These results illustrate the detrimental consequences of interrupting highly conserved regulatory landscapes and reveal a mechanism where genomic duplications lead to partial loss of function of nearby located genes. ..
  39. Jinnah H, Jones M, Wojcik B, Rothstein J, Hess E, Friedmann T, et al. Influence of age and strain on striatal dopamine loss in a genetic mouse model of Lesch-Nyhan disease. J Neurochem. 1999;72:225-9 pubmed
    ..disorder caused by deficiency of the purine salvage enzyme hypoxanthine-guanine phosphoribosyltransferase (HPRT)...
  40. Bronson S, Plaehn E, Kluckman K, Hagaman J, Maeda N, Smithies O. Single-copy transgenic mice with chosen-site integration. Proc Natl Acad Sci U S A. 1996;93:9067-72 pubmed
    ..In vitro and in vivo, the human beta-actin promoter consistently directed a higher level of transgene expression than the chicken beta-actin promoter. ..
  41. Muzumdar M, Tasic B, Miyamichi K, Li L, Luo L. A global double-fluorescent Cre reporter mouse. Genesis. 2007;45:593-605 pubmed
    ..In addition to serving as a global Cre reporter, the mT/mG mouse may also be used as a tool for lineage tracing, transplantation studies, and analysis of cell morphology in vivo. ..
  42. Hooper M, Hardy K, Handyside A, Hunter S, Monk M. HPRT-deficient (Lesch-Nyhan) mouse embryos derived from germline colonization by cultured cells. Nature. 1987;326:292-5 pubmed
    ..by the selection in vitro of variant ES cells deficient in hypoxanthine guanine phosphoribosyl transferase (HPRT; EC 2.4.2...
  43. Ceballos Picot I, Mockel L, Potier M, Dauphinot L, Shirley T, Torero Ibad R, et al. Hypoxanthine-guanine phosphoribosyl transferase regulates early developmental programming of dopamine neurons: implications for Lesch-Nyhan disease pathogenesis. Hum Mol Genet. 2009;18:2317-27 pubmed publisher
    Hypoxanthine-guanine phosphoribosyltransferase (HPRT) deficiency results in Lesch-Nyhan disease (LND), where affected individuals exhibit a characteristic neurobehavioral disorder that has been linked with dysfunction of dopaminergic ..
  44. Evans V, Hatzopoulos A, Aird W, Rayburn H, Rosenberg R, Kuivenhoven J. Targeting the Hprt locus in mice reveals differential regulation of Tie2 gene expression in the endothelium. Physiol Genomics. 2000;2:67-75 pubmed
    ..To study the in vivo expression of the murine Tie2 gene, we have targeted the hypoxanthine phosphoribosyltransferase (Hprt) gene locus to generate two single-copy transgenic mice: T1, containing the 2,100-bp Tie2 promoter upstream from ..
  45. Jinnah H, Gage F, Friedmann T. Amphetamine-induced behavioral phenotype in a hypoxanthine-guanine phosphoribosyltransferase-deficient mouse model of Lesch-Nyhan syndrome. Behav Neurosci. 1991;105:1004-12 pubmed
    In humans, congenital deficiency of the enzyme hypoxanthine-guanine phosphoribosyltransferase (HPRT) results in a disorder known as the Lesch-Nyhan syndrome...
  46. Portales Casamar E, Swanson D, Liu L, de Leeuw C, Banks K, Ho Sui S, et al. A regulatory toolbox of MiniPromoters to drive selective expression in the brain. Proc Natl Acad Sci U S A. 2010;107:16589-94 pubmed publisher
    ..quot;knockins" in embryonic stem cells, each MiniPromoter reporter is integrated immediately 5' of the Hprt locus in the mouse genome...
  47. Lewers J, Ceballos Picot I, Shirley T, Mockel L, Egami K, Jinnah H. Consequences of impaired purine recycling in dopaminergic neurons. Neuroscience. 2008;152:761-72 pubmed publisher
    ..or mice with inherited defects of the purine recycling enzyme hypoxanthine-guanine phosphoribosyltransferase (HPRT), the most prominent defect is loss of basal ganglia dopamine...
  48. Ryu K, Maehr R, Gilchrist C, Long M, Bouley D, Mueller B, et al. The mouse polyubiquitin gene UbC is essential for fetal liver development, cell-cycle progression and stress tolerance. EMBO J. 2007;26:2693-706 pubmed
    ..can be rescued by providing additional Ub from a poly hemagglutinin-tagged Ub minigene expressed from the Hprt locus. We propose that UbC is regulated by a process that senses Ub pool dynamics...
  49. Coleman D. Effect of genic substitution on the incorporation of tyrosine into the melanin of mouse skin. Arch Biochem Biophys. 1962;96:562-8 pubmed
  50. Gee J, Smith N, Fernandez F, Economo M, Brunert D, Rothermel M, et al. Imaging activity in neurons and glia with a Polr2a-based and cre-dependent GCaMP5G-IRES-tdTomato reporter mouse. Neuron. 2014;83:1058-72 pubmed publisher
    ..Through electrophysiological and behavioral analyses, we determined that GCaMP5G expression had no major impact on nervous system performance. PC::G5-tdT will be instrumental for a variety of brain mapping experiments. ..
  51. McMahon A, Butovich I, Kedzierski W. Epidermal expression of an Elovl4 transgene rescues neonatal lethality of homozygous Stargardt disease-3 mice. J Lipid Res. 2011;52:1128-38 pubmed publisher
    ..In addition to the skin, Elovl4 is also expressed in other tissues, including the retina, brain, and testes. Thus, these mice will facilitate future studies to define the roles of C28-C36 fatty acids in the Elovl4-expressing tissues. ..
  52. Dewan A, Pacifico R, Zhan R, Rinberg D, Bozza T. Non-redundant coding of aversive odours in the main olfactory pathway. Nature. 2013;497:486-9 pubmed publisher
    ..In addition, our data reveal that aversive amines are represented in a non-redundant fashion, and that individual main olfactory receptor genes can contribute substantially to odour perception. ..
  53. Zaremba K, Reeder A, Kowalkowski A, Girma E, Nichol P. Utility and limits of Hprt-Cre technology in generating mutant mouse embryos. J Surg Res. 2014;187:386-93 pubmed publisher
    b>Hprt-Cre doubles the prevalence of homozygous null embryos per litter versus heterozygous breedings without decreasing litter size. Resulting mutant embryos are genotypically and phenotypically equivalent between strategies...
  54. Gautier E, Huby T, Witztum J, Ouzilleau B, Miller E, Saint Charles F, et al. Macrophage apoptosis exerts divergent effects on atherogenesis as a function of lesion stage. Circulation. 2009;119:1795-804 pubmed publisher
  55. Piszczek L, Piszczek A, Kuczmanska J, Audero E, Gross C. Modulation of anxiety by cortical serotonin 1A receptors. Front Behav Neurosci. 2015;9:48 pubmed publisher
    ..Together with previous findings, these results support a hetero/auto-receptor interaction model for Htr1a function in anxiety. ..
  56. Goh A, Lim C, Chiam P, Li L, Mann M, Mann K, et al. Using targeted transgenic reporter mice to study promoter-specific p53 transcriptional activity. Proc Natl Acad Sci U S A. 2012;109:1685-90 pubmed publisher
    ..5. The data from this study demonstrate that these reporter mice could serve as powerful tools to answer questions related to basic biology of the p53 pathway, as well as cancer therapy and drug discovery. ..
  57. Pandya K, Cowhig J, Brackhan J, Kim H, Hagaman J, Rojas M, et al. Discordant on/off switching of gene expression in myocytes during cardiac hypertrophy in vivo. Proc Natl Acad Sci U S A. 2008;105:13063-8 pubmed publisher
  58. Redeker C, Schuster Gossler K, Kremmer E, Gossler A. Normal development in mice over-expressing the intracellular domain of DLL1 argues against reverse signaling by DLL1 in vivo. PLoS ONE. 2013;8:e79050 pubmed publisher
    ..In addition, we show that mouse DICD enters the nucleus inefficiently. Collectively, our results argue against a signaling activity of the intracellular domain of DLL1 in mouse embryos in vivo. ..