Hpgd

Summary

Gene Symbol: Hpgd
Description: hydroxyprostaglandin dehydrogenase 15 (NAD)
Alias: 15-PGDH, AV026552, 15-hydroxyprostaglandin dehydrogenase [NAD(+)], 15-hydroxyprostaglandin dehydrogenase, PGDH, prostaglandin dehydrogenase 1
Species: mouse

Top Publications

  1. ncbi Increased Expression of 15-Hydroxyprostaglandin Dehydrogenase in Spinal Astrocytes During Disease Progression in a Model of Amyotrophic Lateral Sclerosis
    Hiroko Miyagishi
    School of Pharmacy, Nihon University, 7 7 1 Narashinodai, Funabashi, Chiba, 274 8555, Japan
    Cell Mol Neurobiol . 2016
  2. pmc TISSUE REGENERATION. Inhibition of the prostaglandin-degrading enzyme 15-PGDH potentiates tissue regeneration
    Yongyou Zhang
    Department of Medicine, Case Western Reserve University, Cleveland, OH 44106, USA
    Science 348:aaa2340. 2015
  3. pmc Sulindac reversal of 15-PGDH-mediated resistance to colon tumor chemoprevention with NSAIDs
    Stephen P Fink
    Department of Medicine and Case Comprehensive Cancer Center, Case Western Reserve University and Case Medical Center, Cleveland, OH 44106, USA
    Carcinogenesis 36:291-8. 2015
  4. doi Regulation of 15-hydroxyprostaglandin dehydrogenase expression in hepatocellular carcinoma
    Luis Castro-Sanchez
    Instituto de Investigaciones Biomedicas Alberto Sols, CSIC UAM, Arturo Duperier, 4, 28029 Madrid, Spain
    Int J Biochem Cell Biol 45:2501-11. 2013
  5. doi Lipopolysaccharide-induced murine embryonic resorption involves nitric oxide-mediated inhibition of the NAD+-dependent 15-hydroxyprostaglandin dehydrogenase
    Julieta Aisemberg
    Centro de Estudios Farmacologicos y Botanicos CEFYBO, CONICET UBA, Facultad de Medicina, Universidad de Buenos Aires, Buenos Aires, Argentina
    Reproduction 144:447-54. 2012
  6. pmc Preconception omega-3 fatty acid supplementation of adult male mice with a history of developmental 2,3,7,8-tetrachlorodibenzo-p-dioxin exposure prevents preterm birth in unexposed female partners
    Melinda E McConaha
    Women s Reproductive Health Research Center, Department of Obstetrics and Gynecology, Vanderbilt University School of Medicine, 1161 21st Avenue S, MCN B 1100, Nashville, Tennessee 37232, USA
    Reproduction 142:235-41. 2011
  7. doi The Hippocratic finger points the blame at PGE2
    Kenneth G Coggins
    Nat Genet 40:691-2. 2008
  8. doi Involvement of the constitutive prostaglandin E synthase cPGES/p23 in expression of an initial prostaglandin E2 inactivating enzyme, 15-PGDH
    Yoshihito Nakatani
    Department of Health Chemistry, School of Pharmaceutical Sciences, Showa University, 1 5 8 Hatanodai, Shinagawa ku, Tokyo 142 8555, Japan
    Prostaglandins Other Lipid Mediat 94:112-7. 2011
  9. doi Antidiabetic effects and gene expression profiling in obese mice treated with Isaria sinclairii over a 6-month period
    Mi Young Ahn
    Department of Agricultural Biology, National Academy of Agricultural Science, RDA, 61 Seodun Dong, Kwunseon gu, Suwon 441 100, Korea
    J Toxicol Environ Health A 73:1511-20. 2010
  10. pmc A novel transporter of SLC22 family specifically transports prostaglandins and co-localizes with 15-hydroxyprostaglandin dehydrogenase in renal proximal tubules
    Katsuko Shiraya
    Department of Pharmacology and Toxicology, Kyorin University School of Medicine, Mitaka, Tokyo 181 8611, Japan
    J Biol Chem 285:22141-51. 2010

Scientific Experts

  • J Aisemberg
  • Yoshihito Nakatani
  • Stephen P Fink
  • Sanford D Markowitz
  • Hsin Hsiung Tai
  • Kenneth G Coggins
  • Yongyou Zhang
  • Min Yan
  • Hiroko Miyagishi
  • Seung Jae Myung
  • Joseph E Willis
  • Dawn M Dawson
  • Beverly H Koller
  • Luis Castro-Sanchez
  • Jill S Barnholtz-Sloan
  • Peiying Yang
  • Melinda E McConaha
  • Ginger L Milne
  • Mi Young Ahn
  • Katsuko Shiraya
  • Bing Yao
  • Jeffrey D Roizen
  • Ronald M Rerko
  • Dawn Dawson
  • Joseph Willis
  • Robert A Newman
  • Earl Lawrence
  • Wen Ling Chou
  • Alysia Kern Lovgren
  • Leslie C Jones
  • John M Hartney
  • Thomas M Coffman
  • Michael G Backlund
  • M Matsuo
  • Dai Hirose
  • Ayumi Takano
  • Kumiko Ishige
  • Manami Endo
  • Yoshihisa Ito
  • Yoko Tanaka
  • Rui Kano
  • Yasuhiro Kosuge
  • Hiroshi Nango
  • Somay Yamagata-Murayama
  • Debra Mikkola
  • Bruce Posner
  • Lakshmi Kasturi
  • James K V Willson
  • Zora Djuric
  • Sung Yeun Yang
  • Wei Dong Chen
  • Noelle S Williams
  • Adam Kresak
  • Earl G Lawrence
  • Levy Kopelovich
  • Ki Beom Bae
  • Shuguang Wei
  • Amar Desai
  • Gretchen A LaRusch
  • Luca Di Martino
  • David Wald
  • Monika I Antczak
  • Joseph M Ready
  • Juan Sanabria
  • Chris Dealwis
  • MARK CHANCE
  • Shruti Tiwari
  • Zhenghe Wang
  • Jacinth Naidoo
  • Yanwen Chen
  • Fabio Cominelli
  • Stanton L Gerson
  • Lucy He
  • H H Tai
  • Noelia Agra
  • Marta Casado
  • Paloma Martin-Sanz
  • Omar MotiƱo
  • Cristina Llorente Izquierdo
  • Lisardo Bosca
  • H Zhou
  • Joe A Arosh
  • Kaylon L Bruner-Tran
  • Tianbing Ding
  • John A Lucas
  • Kevin G Osteen
  • Eun Young Yun
  • Shinji Asano
  • Ji Hye Yeon
  • Promsuk Jutabha

Detail Information

Publications22

  1. ncbi Increased Expression of 15-Hydroxyprostaglandin Dehydrogenase in Spinal Astrocytes During Disease Progression in a Model of Amyotrophic Lateral Sclerosis
    Hiroko Miyagishi
    School of Pharmacy, Nihon University, 7 7 1 Narashinodai, Funabashi, Chiba, 274 8555, Japan
    Cell Mol Neurobiol . 2016
    ..In the present study, we investigated the protein level of 15-hydroxyprostaglandin dehydrogenase (15-PGDH), a key enzyme in prostaglandin metabolism, in ALS model mice at three different disease stages...
  2. pmc TISSUE REGENERATION. Inhibition of the prostaglandin-degrading enzyme 15-PGDH potentiates tissue regeneration
    Yongyou Zhang
    Department of Medicine, Case Western Reserve University, Cleveland, OH 44106, USA
    Science 348:aaa2340. 2015
    ..Here, we show that inhibition of 15-hydroxyprostaglandin dehydrogenase (15-PGDH), a prostaglandin-degrading enzyme, potentiates tissue regeneration in multiple organs in mice...
  3. pmc Sulindac reversal of 15-PGDH-mediated resistance to colon tumor chemoprevention with NSAIDs
    Stephen P Fink
    Department of Medicine and Case Comprehensive Cancer Center, Case Western Reserve University and Case Medical Center, Cleveland, OH 44106, USA
    Carcinogenesis 36:291-8. 2015
    ..15-hydroxyprostaglandin dehydrogenase (15-PGDH) is a tumor suppressor that degrades tumor-promoting prostaglandins...
  4. doi Regulation of 15-hydroxyprostaglandin dehydrogenase expression in hepatocellular carcinoma
    Luis Castro-Sanchez
    Instituto de Investigaciones Biomedicas Alberto Sols, CSIC UAM, Arturo Duperier, 4, 28029 Madrid, Spain
    Int J Biochem Cell Biol 45:2501-11. 2013
    ..pathways involving nicotinamide adenine dinucleotide (NAD(+))-dependent 15-hydroxyprostaglandin dehydrogenase (15-PGDH). 15-PGDH is a crucial enzyme responsible for the biological inactivation of PGE2...
  5. doi Lipopolysaccharide-induced murine embryonic resorption involves nitric oxide-mediated inhibition of the NAD+-dependent 15-hydroxyprostaglandin dehydrogenase
    Julieta Aisemberg
    Centro de Estudios Farmacologicos y Botanicos CEFYBO, CONICET UBA, Facultad de Medicina, Universidad de Buenos Aires, Buenos Aires, Argentina
    Reproduction 144:447-54. 2012
    ..The specific objectives of the study were to evaluate the protein expression of HPGD (15-PGDH) and to characterize the nitric oxide-dependent regulation of this enzyme in a model of lipopolysaccharide ..
  6. pmc Preconception omega-3 fatty acid supplementation of adult male mice with a history of developmental 2,3,7,8-tetrachlorodibenzo-p-dioxin exposure prevents preterm birth in unexposed female partners
    Melinda E McConaha
    Women s Reproductive Health Research Center, Department of Obstetrics and Gynecology, Vanderbilt University School of Medicine, 1161 21st Avenue S, MCN B 1100, Nashville, Tennessee 37232, USA
    Reproduction 142:235-41. 2011
    ..examining the expression of Pgr and Tlr4 mRNA as well as the expression of 15-hydroxyprostaglandin dehydrogenase (PGDH)...
  7. doi The Hippocratic finger points the blame at PGE2
    Kenneth G Coggins
    Nat Genet 40:691-2. 2008
  8. doi Involvement of the constitutive prostaglandin E synthase cPGES/p23 in expression of an initial prostaglandin E2 inactivating enzyme, 15-PGDH
    Yoshihito Nakatani
    Department of Health Chemistry, School of Pharmaceutical Sciences, Showa University, 1 5 8 Hatanodai, Shinagawa ku, Tokyo 142 8555, Japan
    Prostaglandins Other Lipid Mediat 94:112-7. 2011
    ..in cPGES/p23 decreased the expression of the PGE(2) degrading enzyme, 15-hydroxyprostaglandin dehydrogenase (15-PGDH), which catalyzes the inactivating conversion of the PGE(2) 15-OH to a 15-keto group, compared with that of wild-..
  9. doi Antidiabetic effects and gene expression profiling in obese mice treated with Isaria sinclairii over a 6-month period
    Mi Young Ahn
    Department of Agricultural Biology, National Academy of Agricultural Science, RDA, 61 Seodun Dong, Kwunseon gu, Suwon 441 100, Korea
    J Toxicol Environ Health A 73:1511-20. 2010
    ..and 12 genes including cell translocation gene2 (antiproliferative) and hydroxyprostaglandin dehydrogenase (Hpgd 15) were downregulated...
  10. pmc A novel transporter of SLC22 family specifically transports prostaglandins and co-localizes with 15-hydroxyprostaglandin dehydrogenase in renal proximal tubules
    Katsuko Shiraya
    Department of Pharmacology and Toxicology, Kyorin University School of Medicine, Mitaka, Tokyo 181 8611, Japan
    J Biol Chem 285:22141-51. 2010
    ..By removing extracellular PGE(2), OAT-PG is proposed to be involved in the local PGE(2) clearance and metabolism for the inactivation of PG signals in the kidney cortex...
  11. pmc 15-Hydroxyprostaglandin dehydrogenase inactivation as a mechanism of resistance to celecoxib chemoprevention of colon tumors
    Min Yan
    Department of Medicine and Pathology, Ireland Cancer Center, Case Western Reserve University and Case Medical Center, Cleveland, OH 44106, USA
    Proc Natl Acad Sci U S A 106:9409-13. 2009
    ..of the COX-2 inhibitor celecoxib requires the concomitant presence of the 15-hydroxyprostaglandin dehydrogenase (15-PGDH) tumor suppressor gene, and that loss of 15-PGDH expression imparts resistance to celecoxib's anti-tumor effects...
  12. ncbi Cloning and expression of the cDNA for mouse NAD(+)-dependent 15-hydroxyprostaglandin dehydrogenase
    M Matsuo
    Division of Medicinal Chemistry and Pharmaceutics, College of Pharmacy, University of Kentucky, Lexington 40536, USA
    Biochim Biophys Acta 1309:21-4. 1996
    The cDNA for mouse NAD+ dependent 15-hydroxyprostaglandin dehydrogenase (15-PGDH) was isolated from a lung cDNA library...
  13. ncbi Renal localization and regulation of 15-hydroxyprostaglandin dehydrogenase
    Bing Yao
    Division of Nephrology, Vanderbilt University School of Medicine, Nashville, Tennessee 37232, USA
    Am J Physiol Renal Physiol 294:F433-9. 2008
    ..The current studies report the expression and localization of 15-hydroxyprostaglandin dehydrogenase (15-PGDH), a key enzyme in prostaglandin catabolism in the kidneys...
  14. pmc Preterm birth without progesterone withdrawal in 15-hydroxyprostaglandin dehydrogenase hypomorphic mice
    Jeffrey D Roizen
    Washington University School of Medicine, St Louis, Missouri 63110, USA
    Mol Endocrinol 22:105-12. 2008
    ..Thus, endocrine control of labor has the capacity to plastically adapt to changes in genetically determined prostaglandin signals...
  15. ncbi Identification of a novel prostaglandin reductase reveals the involvement of prostaglandin E2 catabolism in regulation of peroxisome proliferator-activated receptor gamma activation
    Wen Ling Chou
    Institute of Biochemistry and Molecular Biology, College of Medicine, National Taiwan University, and Department of Internal Medicine, National Taiwan University Hospital, Taipei 100, Taiwan
    J Biol Chem 282:18162-72. 2007
    ..These results demonstrate a novel link between catabolism of PGE2 and regulation of ligand-induced PPARgamma activation...
  16. ncbi Quantitative genetic analysis of brain copper and zinc in BXD recombinant inbred mice
    Leslie C Jones
    Nutritional Neuroscience Program, The Pennsylvania State University, University Park, PA 16802, USA
    Nutr Neurosci 9:81-92. 2006
    ..More importantly, revelation of the genetic underpinnings of copper and zinc brain homeostasis will aid our understanding of neurological diseases that are related to copper and zinc imbalance...
  17. pmc 15-Hydroxyprostaglandin dehydrogenase is an in vivo suppressor of colon tumorigenesis
    Seung Jae Myung
    Department of Medicine, Case Western Reserve University, University Hospitals of Cleveland, Cleveland, OH 44106, USA
    Proc Natl Acad Sci U S A 103:12098-102. 2006
    15-Hydroxyprostaglandin dehydrogenase (15-PGDH) is a prostaglandin-degrading enzyme that is highly expressed in normal colon mucosa but is ubiquitously lost in human colon cancers...
  18. ncbi Prostaglandin E2 protects lower airways against bronchoconstriction
    John M Hartney
    Curriculum in Genetics and Molecular Biology, University of North Carolina, Chapel Hill, NC 27599, USA
    Am J Physiol Lung Cell Mol Physiol 290:L105-13. 2006
    ..PGE2 levels were elevated by generating mice lacking 15-hydroxyprostaglandin (Hpgd-/-), the major catabolic enzyme of PGE2, and by generating a transgenic line in which mouse PGE2 synthase (Ptges) ..
  19. pmc 15-Hydroxyprostaglandin dehydrogenase is down-regulated in colorectal cancer
    Michael G Backlund
    Department of Medicine, Cell and Developmental Biology, Vanderbilt University Medical Center and the Vanderbilt Ingram Cancer Center, Nashville, Tennessee 37232 6838, USA
    J Biol Chem 280:3217-23. 2005
    ..Enzymatic degradation of PGE2 involves the NAD+-dependent 15-hydroxyprostaglandin dehydrogenase (15-PGDH)...
  20. ncbi Metabolism of PGE2 by prostaglandin dehydrogenase is essential for remodeling the ductus arteriosus
    Kenneth G Coggins
    Department of Medicine, University of North Carolina, Chapel Hill, USA
    Nat Med 8:91-2. 2002
  21. ncbi C-Terminal region of human NAD+-dependent 15-hydroxyprostaglandin dehydrogenase is involved in the interaction with prostaglandin substrates
    H Zhou
    Division of Pharmaceutical Sciences, College of Pharmacy, University of Kentucky, Lexington, KY 40536 0082, USA
    Eur J Biochem 268:3368-74. 2001
    NAD+-dependent 15-hydroxyprostaglandin dehydrogenase (15-PGDH) catalyzes the oxidation of the 15(S) hydroxyl group of prostaglandins to a 15-keto group resulting in a significant reduction of the biological activities of prostaglandins...
  22. ncbi Characterization of the genomic structure and promoter of the mouse NAD+-dependent 15-hydroxyprostaglandin dehydrogenase gene
    M Matsuo
    Division of Medicinal Chemistry and Pharmaceutics, College of Pharmacy, University of Kentucky, Lexington 40536 0082, USA
    Biochem Biophys Res Commun 235:582-6. 1997
    The mouse NAD+-dependent 15-hydroxyprostaglandin dehydrogenase (15-PGDH) gene and its 5'-flanking region was cloned from a 129 mouse ES bacteriophage P1 genomic library. The gene contains 7 exons and 6 introns and is 11.3 kb in length...