Gene Symbol: Hpgd
Description: hydroxyprostaglandin dehydrogenase 15 (NAD)
Alias: 15-PGDH, AV026552, 15-hydroxyprostaglandin dehydrogenase [NAD(+)], 15-hydroxyprostaglandin dehydrogenase, PGDH, prostaglandin dehydrogenase 1
Species: mouse
Products:     Hpgd

Top Publications

  1. Matsuo M, Ensor C, Tai H. Characterization of the genomic structure and promoter of the mouse NAD+-dependent 15-hydroxyprostaglandin dehydrogenase gene. Biochem Biophys Res Commun. 1997;235:582-6 pubmed
    The mouse NAD+-dependent 15-hydroxyprostaglandin dehydrogenase (15-PGDH) gene and its 5'-flanking region was cloned from a 129 mouse ES bacteriophage P1 genomic library. The gene contains 7 exons and 6 introns and is 11.3 kb in length...
  2. Coggins K, Latour A, Nguyen M, Audoly L, Coffman T, Koller B. Metabolism of PGE2 by prostaglandin dehydrogenase is essential for remodeling the ductus arteriosus. Nat Med. 2002;8:91-2 pubmed
  3. Castro Sanchez L, Agra N, Llorente Izquierdo C, MotiƱo O, Casado M, Bosca L, et al. Regulation of 15-hydroxyprostaglandin dehydrogenase expression in hepatocellular carcinoma. Int J Biochem Cell Biol. 2013;45:2501-11 pubmed publisher
    ..pathways involving nicotinamide adenine dinucleotide (NAD(+))-dependent 15-hydroxyprostaglandin dehydrogenase (15-PGDH). 15-PGDH is a crucial enzyme responsible for the biological inactivation of PGE2...
  4. Hartney J, Coggins K, Tilley S, Jania L, Lovgren A, Audoly L, et al. Prostaglandin E2 protects lower airways against bronchoconstriction. Am J Physiol Lung Cell Mol Physiol. 2006;290:L105-13 pubmed
    ..PGE2 levels were elevated by generating mice lacking 15-hydroxyprostaglandin (Hpgd-/-), the major catabolic enzyme of PGE2, and by generating a transgenic line in which mouse PGE2 synthase (Ptges) ..
  5. Roizen J, Asada M, Tong M, Tai H, Muglia L. Preterm birth without progesterone withdrawal in 15-hydroxyprostaglandin dehydrogenase hypomorphic mice. Mol Endocrinol. 2008;22:105-12 pubmed
    ..Thus, endocrine control of labor has the capacity to plastically adapt to changes in genetically determined prostaglandin signals. ..
  6. Matsuo M, Ensor C, Tai H. Cloning and expression of the cDNA for mouse NAD(+)-dependent 15-hydroxyprostaglandin dehydrogenase. Biochim Biophys Acta. 1996;1309:21-4 pubmed
    The cDNA for mouse NAD+ dependent 15-hydroxyprostaglandin dehydrogenase (15-PGDH) was isolated from a lung cDNA library...
  7. Coggins K, Coffman T, Koller B. The Hippocratic finger points the blame at PGE2. Nat Genet. 2008;40:691-2 pubmed publisher
  8. Fink S, Dawson D, Zhang Y, Kresak A, Lawrence E, Yang P, et al. Sulindac reversal of 15-PGDH-mediated resistance to colon tumor chemoprevention with NSAIDs. Carcinogenesis. 2015;36:291-8 pubmed publisher
    ..15-hydroxyprostaglandin dehydrogenase (15-PGDH) is a tumor suppressor that degrades tumor-promoting prostaglandins...
  9. Aisemberg J, Bariani M, Vercelli C, Wolfson M, Franchi A. Lipopolysaccharide-induced murine embryonic resorption involves nitric oxide-mediated inhibition of the NAD+-dependent 15-hydroxyprostaglandin dehydrogenase. Reproduction. 2012;144:447-54 pubmed publisher
    The initial inactivation of prostaglandins (PGs) is mediated by 15-hydroxyprostaglandin dehydrogenase (15-PGDH). PGs are potent mediators of several biological processes, including inflammation and reproduction...

More Information


  1. Ahn M, Jee S, Lee B, Yeon J, Park K, Hwang J, et al. Antidiabetic effects and gene expression profiling in obese mice treated with Isaria sinclairii over a 6-month period. J Toxicol Environ Health A. 2010;73:1511-20 pubmed publisher
    ..and 12 genes including cell translocation gene2 (antiproliferative) and hydroxyprostaglandin dehydrogenase (Hpgd 15) were downregulated...
  2. Shiraya K, Hirata T, Hatano R, Nagamori S, Wiriyasermkul P, Jutabha P, et al. A novel transporter of SLC22 family specifically transports prostaglandins and co-localizes with 15-hydroxyprostaglandin dehydrogenase in renal proximal tubules. J Biol Chem. 2010;285:22141-51 pubmed publisher
    ..By removing extracellular PGE(2), OAT-PG is proposed to be involved in the local PGE(2) clearance and metabolism for the inactivation of PG signals in the kidney cortex. ..
  3. Chou W, Chuang L, Chou C, Wang A, Lawson J, Fitzgerald G, et al. Identification of a novel prostaglandin reductase reveals the involvement of prostaglandin E2 catabolism in regulation of peroxisome proliferator-activated receptor gamma activation. J Biol Chem. 2007;282:18162-72 pubmed
    ..These results demonstrate a novel link between catabolism of PGE2 and regulation of ligand-induced PPARgamma activation. ..
  4. Myung S, Rerko R, Yan M, Platzer P, Guda K, Dotson A, et al. 15-Hydroxyprostaglandin dehydrogenase is an in vivo suppressor of colon tumorigenesis. Proc Natl Acad Sci U S A. 2006;103:12098-102 pubmed
    15-Hydroxyprostaglandin dehydrogenase (15-PGDH) is a prostaglandin-degrading enzyme that is highly expressed in normal colon mucosa but is ubiquitously lost in human colon cancers...
  5. Zhou H, Yan F, Tai H. C-Terminal region of human NAD+-dependent 15-hydroxyprostaglandin dehydrogenase is involved in the interaction with prostaglandin substrates. Eur J Biochem. 2001;268:3368-74 pubmed
    NAD+-dependent 15-hydroxyprostaglandin dehydrogenase (15-PGDH) catalyzes the oxidation of the 15(S) hydroxyl group of prostaglandins to a 15-keto group resulting in a significant reduction of the biological activities of prostaglandins...
  6. Yao B, Xu J, Harris R, Zhang M. Renal localization and regulation of 15-hydroxyprostaglandin dehydrogenase. Am J Physiol Renal Physiol. 2008;294:F433-9 pubmed
    ..The current studies report the expression and localization of 15-hydroxyprostaglandin dehydrogenase (15-PGDH), a key enzyme in prostaglandin catabolism in the kidneys...
  7. Yan M, Myung S, Fink S, Lawrence E, Lutterbaugh J, Yang P, et al. 15-Hydroxyprostaglandin dehydrogenase inactivation as a mechanism of resistance to celecoxib chemoprevention of colon tumors. Proc Natl Acad Sci U S A. 2009;106:9409-13 pubmed publisher
    ..of the COX-2 inhibitor celecoxib requires the concomitant presence of the 15-hydroxyprostaglandin dehydrogenase (15-PGDH) tumor suppressor gene, and that loss of 15-PGDH expression imparts resistance to celecoxib's anti-tumor effects...
  8. Jones L, McCarthy K, Beard J, Keen C, Jones B. Quantitative genetic analysis of brain copper and zinc in BXD recombinant inbred mice. Nutr Neurosci. 2006;9:81-92 pubmed
    ..More importantly, revelation of the genetic underpinnings of copper and zinc brain homeostasis will aid our understanding of neurological diseases that are related to copper and zinc imbalance. ..
  9. Nakatani Y, Hokonohara Y, Tajima Y, Kudo I, Hara S. Involvement of the constitutive prostaglandin E synthase cPGES/p23 in expression of an initial prostaglandin E2 inactivating enzyme, 15-PGDH. Prostaglandins Other Lipid Mediat. 2011;94:112-7 pubmed publisher
    ..in cPGES/p23 decreased the expression of the PGE(2) degrading enzyme, 15-hydroxyprostaglandin dehydrogenase (15-PGDH), which catalyzes the inactivating conversion of the PGE(2) 15-OH to a 15-keto group, compared with that of wild-..
  10. McConaha M, Ding T, Lucas J, Arosh J, Osteen K, Bruner Tran K. Preconception omega-3 fatty acid supplementation of adult male mice with a history of developmental 2,3,7,8-tetrachlorodibenzo-p-dioxin exposure prevents preterm birth in unexposed female partners. Reproduction. 2011;142:235-41 pubmed publisher
    ..examining the expression of Pgr and Tlr4 mRNA as well as the expression of 15-hydroxyprostaglandin dehydrogenase (PGDH)...
  11. Backlund M, Mann J, Holla V, Buchanan F, Tai H, Musiek E, et al. 15-Hydroxyprostaglandin dehydrogenase is down-regulated in colorectal cancer. J Biol Chem. 2005;280:3217-23 pubmed
    ..Enzymatic degradation of PGE2 involves the NAD+-dependent 15-hydroxyprostaglandin dehydrogenase (15-PGDH)...
  12. Zhang Y, Desai A, Yang S, Bae K, Antczak M, Fink S, et al. TISSUE REGENERATION. Inhibition of the prostaglandin-degrading enzyme 15-PGDH potentiates tissue regeneration. Science. 2015;348:aaa2340 pubmed publisher
    ..Here, we show that inhibition of 15-hydroxyprostaglandin dehydrogenase (15-PGDH), a prostaglandin-degrading enzyme, potentiates tissue regeneration in multiple organs in mice...
  13. Miyagishi H, Kosuge Y, Takano A, Endo M, Nango H, Yamagata Murayama S, et al. Increased Expression of 15-Hydroxyprostaglandin Dehydrogenase in Spinal Astrocytes During Disease Progression in a Model of Amyotrophic Lateral Sclerosis. Cell Mol Neurobiol. 2017;37:445-452 pubmed publisher
    ..In the present study, we investigated the protein level of 15-hydroxyprostaglandin dehydrogenase (15-PGDH), a key enzyme in prostaglandin metabolism, in ALS model mice at three different disease stages...
  14. Yao L, Chen W, Song K, Han C, Gandhi C, Lim K, et al. 15-hydroxyprostaglandin dehydrogenase (15-PGDH) prevents lipopolysaccharide (LPS)-induced acute liver injury. PLoS ONE. 2017;12:e0176106 pubmed publisher
    The NAD+-dependent 15-hydroxyprostaglandin dehydrogenase (15-PGDH) catalyzes the oxidation of the 15(S)-hydroxyl group of prostaglandin E2 (PGE2), converting the pro-inflammatory PGE2 to the anti-inflammatory 15-keto-PGE2 (an endogenous ..