Genomes and Genes
Gene Symbol: Hpgd
Description: hydroxyprostaglandin dehydrogenase 15 (NAD)
Alias: 15-PGDH, AV026552, 15-hydroxyprostaglandin dehydrogenase [NAD(+)], 15-hydroxyprostaglandin dehydrogenase, PGDH, prostaglandin dehydrogenase 1
- Increased Expression of 15-Hydroxyprostaglandin Dehydrogenase in Spinal Astrocytes During Disease Progression in a Model of Amyotrophic Lateral SclerosisHiroko Miyagishi
School of Pharmacy, Nihon University, 7 7 1 Narashinodai, Funabashi, Chiba, 274 8555, Japan
Cell Mol Neurobiol . 2016..In the present study, we investigated the protein level of 15-hydroxyprostaglandin dehydrogenase (15-PGDH), a key enzyme in prostaglandin metabolism, in ALS model mice at three different disease stages...
- TISSUE REGENERATION. Inhibition of the prostaglandin-degrading enzyme 15-PGDH potentiates tissue regenerationYongyou Zhang
Department of Medicine, Case Western Reserve University, Cleveland, OH 44106, USA
Science 348:aaa2340. 2015..Here, we show that inhibition of 15-hydroxyprostaglandin dehydrogenase (15-PGDH), a prostaglandin-degrading enzyme, potentiates tissue regeneration in multiple organs in mice...
- Sulindac reversal of 15-PGDH-mediated resistance to colon tumor chemoprevention with NSAIDsStephen P Fink
Department of Medicine and Case Comprehensive Cancer Center, Case Western Reserve University and Case Medical Center, Cleveland, OH 44106, USA
Carcinogenesis 36:291-8. 2015..15-hydroxyprostaglandin dehydrogenase (15-PGDH) is a tumor suppressor that degrades tumor-promoting prostaglandins...
- Regulation of 15-hydroxyprostaglandin dehydrogenase expression in hepatocellular carcinomaLuis Castro-Sanchez
Instituto de Investigaciones Biomedicas Alberto Sols, CSIC UAM, Arturo Duperier, 4, 28029 Madrid, Spain
Int J Biochem Cell Biol 45:2501-11. 2013..pathways involving nicotinamide adenine dinucleotide (NAD(+))-dependent 15-hydroxyprostaglandin dehydrogenase (15-PGDH). 15-PGDH is a crucial enzyme responsible for the biological inactivation of PGE2...
- Lipopolysaccharide-induced murine embryonic resorption involves nitric oxide-mediated inhibition of the NAD+-dependent 15-hydroxyprostaglandin dehydrogenaseJulieta Aisemberg
Centro de Estudios Farmacologicos y Botanicos CEFYBO, CONICET UBA, Facultad de Medicina, Universidad de Buenos Aires, Buenos Aires, Argentina
Reproduction 144:447-54. 2012..The specific objectives of the study were to evaluate the protein expression of HPGD (15-PGDH) and to characterize the nitric oxide-dependent regulation of this enzyme in a model of lipopolysaccharide ..
- Preconception omega-3 fatty acid supplementation of adult male mice with a history of developmental 2,3,7,8-tetrachlorodibenzo-p-dioxin exposure prevents preterm birth in unexposed female partnersMelinda E McConaha
Women s Reproductive Health Research Center, Department of Obstetrics and Gynecology, Vanderbilt University School of Medicine, 1161 21st Avenue S, MCN B 1100, Nashville, Tennessee 37232, USA
Reproduction 142:235-41. 2011..examining the expression of Pgr and Tlr4 mRNA as well as the expression of 15-hydroxyprostaglandin dehydrogenase (PGDH)...
- The Hippocratic finger points the blame at PGE2Kenneth G Coggins
Nat Genet 40:691-2. 2008
- Involvement of the constitutive prostaglandin E synthase cPGES/p23 in expression of an initial prostaglandin E2 inactivating enzyme, 15-PGDHYoshihito Nakatani
Department of Health Chemistry, School of Pharmaceutical Sciences, Showa University, 1 5 8 Hatanodai, Shinagawa ku, Tokyo 142 8555, Japan
Prostaglandins Other Lipid Mediat 94:112-7. 2011..in cPGES/p23 decreased the expression of the PGE(2) degrading enzyme, 15-hydroxyprostaglandin dehydrogenase (15-PGDH), which catalyzes the inactivating conversion of the PGE(2) 15-OH to a 15-keto group, compared with that of wild-..
- Antidiabetic effects and gene expression profiling in obese mice treated with Isaria sinclairii over a 6-month periodMi Young Ahn
Department of Agricultural Biology, National Academy of Agricultural Science, RDA, 61 Seodun Dong, Kwunseon gu, Suwon 441 100, Korea
J Toxicol Environ Health A 73:1511-20. 2010..and 12 genes including cell translocation gene2 (antiproliferative) and hydroxyprostaglandin dehydrogenase (Hpgd 15) were downregulated...
- A novel transporter of SLC22 family specifically transports prostaglandins and co-localizes with 15-hydroxyprostaglandin dehydrogenase in renal proximal tubulesKatsuko Shiraya
Department of Pharmacology and Toxicology, Kyorin University School of Medicine, Mitaka, Tokyo 181 8611, Japan
J Biol Chem 285:22141-51. 2010..By removing extracellular PGE(2), OAT-PG is proposed to be involved in the local PGE(2) clearance and metabolism for the inactivation of PG signals in the kidney cortex...
- 15-Hydroxyprostaglandin dehydrogenase inactivation as a mechanism of resistance to celecoxib chemoprevention of colon tumorsMin Yan
Department of Medicine and Pathology, Ireland Cancer Center, Case Western Reserve University and Case Medical Center, Cleveland, OH 44106, USA
Proc Natl Acad Sci U S A 106:9409-13. 2009..of the COX-2 inhibitor celecoxib requires the concomitant presence of the 15-hydroxyprostaglandin dehydrogenase (15-PGDH) tumor suppressor gene, and that loss of 15-PGDH expression imparts resistance to celecoxib's anti-tumor effects...
- Cloning and expression of the cDNA for mouse NAD(+)-dependent 15-hydroxyprostaglandin dehydrogenaseM Matsuo
Division of Medicinal Chemistry and Pharmaceutics, College of Pharmacy, University of Kentucky, Lexington 40536, USA
Biochim Biophys Acta 1309:21-4. 1996The cDNA for mouse NAD+ dependent 15-hydroxyprostaglandin dehydrogenase (15-PGDH) was isolated from a lung cDNA library...
- Renal localization and regulation of 15-hydroxyprostaglandin dehydrogenaseBing Yao
Division of Nephrology, Vanderbilt University School of Medicine, Nashville, Tennessee 37232, USA
Am J Physiol Renal Physiol 294:F433-9. 2008..The current studies report the expression and localization of 15-hydroxyprostaglandin dehydrogenase (15-PGDH), a key enzyme in prostaglandin catabolism in the kidneys...
- Preterm birth without progesterone withdrawal in 15-hydroxyprostaglandin dehydrogenase hypomorphic miceJeffrey D Roizen
Washington University School of Medicine, St Louis, Missouri 63110, USA
Mol Endocrinol 22:105-12. 2008..Thus, endocrine control of labor has the capacity to plastically adapt to changes in genetically determined prostaglandin signals...
- Identification of a novel prostaglandin reductase reveals the involvement of prostaglandin E2 catabolism in regulation of peroxisome proliferator-activated receptor gamma activationWen Ling Chou
Institute of Biochemistry and Molecular Biology, College of Medicine, National Taiwan University, and Department of Internal Medicine, National Taiwan University Hospital, Taipei 100, Taiwan
J Biol Chem 282:18162-72. 2007..These results demonstrate a novel link between catabolism of PGE2 and regulation of ligand-induced PPARgamma activation...
- Quantitative genetic analysis of brain copper and zinc in BXD recombinant inbred miceLeslie C Jones
Nutritional Neuroscience Program, The Pennsylvania State University, University Park, PA 16802, USA
Nutr Neurosci 9:81-92. 2006..More importantly, revelation of the genetic underpinnings of copper and zinc brain homeostasis will aid our understanding of neurological diseases that are related to copper and zinc imbalance...
- 15-Hydroxyprostaglandin dehydrogenase is an in vivo suppressor of colon tumorigenesisSeung Jae Myung
Department of Medicine, Case Western Reserve University, University Hospitals of Cleveland, Cleveland, OH 44106, USA
Proc Natl Acad Sci U S A 103:12098-102. 200615-Hydroxyprostaglandin dehydrogenase (15-PGDH) is a prostaglandin-degrading enzyme that is highly expressed in normal colon mucosa but is ubiquitously lost in human colon cancers...
- Prostaglandin E2 protects lower airways against bronchoconstrictionJohn M Hartney
Curriculum in Genetics and Molecular Biology, University of North Carolina, Chapel Hill, NC 27599, USA
Am J Physiol Lung Cell Mol Physiol 290:L105-13. 2006..PGE2 levels were elevated by generating mice lacking 15-hydroxyprostaglandin (Hpgd-/-), the major catabolic enzyme of PGE2, and by generating a transgenic line in which mouse PGE2 synthase (Ptges) ..
- 15-Hydroxyprostaglandin dehydrogenase is down-regulated in colorectal cancerMichael G Backlund
Department of Medicine, Cell and Developmental Biology, Vanderbilt University Medical Center and the Vanderbilt Ingram Cancer Center, Nashville, Tennessee 37232 6838, USA
J Biol Chem 280:3217-23. 2005..Enzymatic degradation of PGE2 involves the NAD+-dependent 15-hydroxyprostaglandin dehydrogenase (15-PGDH)...
- Metabolism of PGE2 by prostaglandin dehydrogenase is essential for remodeling the ductus arteriosusKenneth G Coggins
Department of Medicine, University of North Carolina, Chapel Hill, USA
Nat Med 8:91-2. 2002
- C-Terminal region of human NAD+-dependent 15-hydroxyprostaglandin dehydrogenase is involved in the interaction with prostaglandin substratesH Zhou
Division of Pharmaceutical Sciences, College of Pharmacy, University of Kentucky, Lexington, KY 40536 0082, USA
Eur J Biochem 268:3368-74. 2001NAD+-dependent 15-hydroxyprostaglandin dehydrogenase (15-PGDH) catalyzes the oxidation of the 15(S) hydroxyl group of prostaglandins to a 15-keto group resulting in a significant reduction of the biological activities of prostaglandins...
- Characterization of the genomic structure and promoter of the mouse NAD+-dependent 15-hydroxyprostaglandin dehydrogenase geneM Matsuo
Division of Medicinal Chemistry and Pharmaceutics, College of Pharmacy, University of Kentucky, Lexington 40536 0082, USA
Biochem Biophys Res Commun 235:582-6. 1997The mouse NAD+-dependent 15-hydroxyprostaglandin dehydrogenase (15-PGDH) gene and its 5'-flanking region was cloned from a 129 mouse ES bacteriophage P1 genomic library. The gene contains 7 exons and 6 introns and is 11.3 kb in length...