Hoxb1

Summary

Gene Symbol: Hoxb1
Description: homeobox B1
Alias: Hox-2.9, homeo box B1, homeobox protein Hox-2.9, homeobox protein Hox-B1
Species: mouse

Top Publications

  1. ncbi Segmental identity can change independently in the hindbrain and rhombencephalic neural crest
    M Mallo
    Max Planck Institute of Immunobiology, Freiburg, Germany
    Dev Dyn 210:146-56. 1997
  2. ncbi The role of Hoxa-3 in mouse thymus and thyroid development
    N R Manley
    Howard Hughes Medical Institute, Department of Human Genetics, University of Utah School of Medicine, Salt Lake City 84112, USA
    Development 121:1989-2003. 1995
  3. pmc Atoh1-lineal neurons are required for hearing and for the survival of neurons in the spiral ganglion and brainstem accessory auditory nuclei
    Stephen M Maricich
    Department of Pediatrics and Neurosciences, Case Western Reserve University, Cleveland, Ohio 44106, USA
    J Neurosci 29:11123-33. 2009
  4. ncbi Hoxb1 controls effectors of sonic hedgehog and Mash1 signaling pathways
    G O Gaufo
    Howard Hughes Medical Institute, Department of Human Genetics, University of Utah, Salt Lake City, UT 84112, USA
    Development 127:5343-54. 2000
  5. ncbi Contribution of Hox genes to the diversity of the hindbrain sensory system
    Gary O Gaufo
    Howard Hughes Medical Institute, Department of Human Genetics, University of Utah, Salt Lake City, UT 84112, USA
    Development 131:1259-66. 2004
  6. ncbi Segmental expression of Hox-2 homoeobox-containing genes in the developing mouse hindbrain
    D G Wilkinson
    Laboratory of Eukaryotic Molecular Genetics, National Institute for Medical Research, London, UK
    Nature 341:405-9. 1989
  7. ncbi Hoxb1 neural crest preferentially form glia of the PNS
    Benjamin R Arenkiel
    Howard Hughes Medical Institute, University of Utah, Salt Lake City, Utah 84112, USA
    Dev Dyn 227:379-86. 2003
  8. ncbi Altered segmental identity and abnormal migration of motor neurons in mice lacking Hoxb-1
    M Studer
    Division of Developmental Neurobiology, MRC National Institute for Medical Research, Mill Hill, London, UK
    Nature 384:630-4. 1996
  9. pmc Coordinated temporal and spatial control of motor neuron and serotonergic neuron generation from a common pool of CNS progenitors
    Alexandre Pattyn
    Department of Cell and Molecular Biology, Karolinska Institute, S 171 77 Stockholm, Sweden
    Genes Dev 17:729-37. 2003
  10. ncbi Role of Hoxa-2 in axon pathfinding and rostral hindbrain patterning
    A Gavalas
    Institut de Genetique et de Biologie Moleculaire et Cellulaire, CNRS INSERM ULP, College de France, CU de Strasbourg
    Development 124:3693-702. 1997

Scientific Experts

  • Laina Freyer
  • Joaquim Egea
  • Karine Rizzoti
  • Stephen O'Gorman
  • Stephen M Maricich
  • Nicolas Bertrand
  • Y Eugene Yu
  • F Gofflot
  • Jacqueline Deschamps
  • Pin Xian Xu
  • Raj K Ladher
  • K Kusumi
  • Jinwoong Bok
  • JAMES YH LI
  • M Mallo
  • J Nardelli
  • D Tomotsune
  • Gary O Gaufo
  • Anthony Gavalas
  • P Chambon
  • Mario R Capecchi
  • R Krumlauf
  • A Gavalas
  • Pascal Dolle
  • M Studer
  • Karen Niederreither
  • Pierre Chambon
  • Christopher S Ward
  • Muriel Rhinn
  • Yiju Chen
  • Robb Krumlauf
  • Peng Li
  • Yibo Qu
  • M R Capecchi
  • Sylvie Forlani
  • Chathurani S Jayasena
  • Takafumi Wataya
  • F M Rijli
  • Catherine A Rottkamp
  • Karim Mesbah
  • Mina Gouti
  • Ana Catarina Correia
  • Virginia E Papaioannou
  • John Jacob
  • Masayuki Uehara
  • Isabelle Anselme
  • Qiuxia Guo
  • Brigitte Schuhbaur
  • V Dupé
  • Henry M Sucov
  • Petr Tvrdik
  • Olov Andersson
  • Deborah L Guris
  • O Wendling
  • Heiko Lickert
  • Stephane D Vincent
  • Séverine Chambeyron
  • Billie A Moore-Scott
  • M Mark
  • Nicolas Matt
  • Elisabetta Ferretti
  • P Charnay
  • Kirstie A Lawson
  • A Lumsden
  • S L Ang
  • Sophie Remacle
  • Makoto M Taketo
  • S Schneider-Maunoury
  • Tomo o Ishikawa
  • Nina Trokovic
  • Koko Urase
  • Virginia S Sadl
  • L Ariza-McNaughton
  • Tracy J Wright
  • Alexandre Pattyn
  • Benjamin R Arenkiel
  • H Marshall
  • T Seitanidou
  • Danyang Huang
  • Bernard A J Roelen
  • M Rossel
  • Xiaobing Jiang
  • J Zakany
  • D G Wilkinson
  • M Rhinn
  • Jong Yoo
  • Masumi Takano-Maruyama
  • E Melissa Arvide
  • Jeffrey L Noebels
  • Jeffrey L Neul

Detail Information

Publications93

  1. ncbi Segmental identity can change independently in the hindbrain and rhombencephalic neural crest
    M Mallo
    Max Planck Institute of Immunobiology, Freiburg, Germany
    Dev Dyn 210:146-56. 1997
    ..We propose a model for the patterning of the branchial region, according to which the segmental identity in this area is provided mainly by the branchial arches...
  2. ncbi The role of Hoxa-3 in mouse thymus and thyroid development
    N R Manley
    Howard Hughes Medical Institute, Department of Human Genetics, University of Utah School of Medicine, Salt Lake City 84112, USA
    Development 121:1989-2003. 1995
    ..This variability suggests the presence of a compensating gene or genes, whose utilization is stochastic. A reasonable candidate for providing this compensatory function is the paralogous gene Hoxb-3...
  3. pmc Atoh1-lineal neurons are required for hearing and for the survival of neurons in the spiral ganglion and brainstem accessory auditory nuclei
    Stephen M Maricich
    Department of Pediatrics and Neurosciences, Case Western Reserve University, Cleveland, Ohio 44106, USA
    J Neurosci 29:11123-33. 2009
    ..We used the Cre-loxP system and two Cre-driver lines (Egr2(Cre) and Hoxb1(Cre)) to delete Atoh1 from different regions of the cochlear nucleus (CN) and accessory auditory nuclei (AAN)...
  4. ncbi Hoxb1 controls effectors of sonic hedgehog and Mash1 signaling pathways
    G O Gaufo
    Howard Hughes Medical Institute, Department of Human Genetics, University of Utah, Salt Lake City, UT 84112, USA
    Development 127:5343-54. 2000
    ..Analyses of the expression and targeted disruption of the homeobox gene Hoxb1 demonstrate that it is essential for patterning progenitor cells along the entire DV axis of rhombomere 4 (r4)...
  5. ncbi Contribution of Hox genes to the diversity of the hindbrain sensory system
    Gary O Gaufo
    Howard Hughes Medical Institute, Department of Human Genetics, University of Utah, Salt Lake City, UT 84112, USA
    Development 131:1259-66. 2004
    ..More generally, these findings contribute to our understanding of how Hox genes specifically control cellular diversity in the developing organism..
  6. ncbi Segmental expression of Hox-2 homoeobox-containing genes in the developing mouse hindbrain
    D G Wilkinson
    Laboratory of Eukaryotic Molecular Genetics, National Institute for Medical Research, London, UK
    Nature 341:405-9. 1989
    ..These data indicate that Hox genes specify segment phenotype, a role analogous to that of their Drosophila homologues...
  7. ncbi Hoxb1 neural crest preferentially form glia of the PNS
    Benjamin R Arenkiel
    Howard Hughes Medical Institute, University of Utah, Salt Lake City, Utah 84112, USA
    Dev Dyn 227:379-86. 2003
    ..using the Cre/loxP system to drive the activation of different ROSA26 reporter alleles under the regulation of the hoxb1 locus...
  8. ncbi Altered segmental identity and abnormal migration of motor neurons in mice lacking Hoxb-1
    M Studer
    Division of Developmental Neurobiology, MRC National Institute for Medical Research, Mill Hill, London, UK
    Nature 384:630-4. 1996
    ..These results demonstrate that, as a part of its role in maintaining rhombomere identity, Hoxb-1 is involved in controlling migratory properties of motor neurons in the hindbrain...
  9. pmc Coordinated temporal and spatial control of motor neuron and serotonergic neuron generation from a common pool of CNS progenitors
    Alexandre Pattyn
    Department of Cell and Molecular Biology, Karolinska Institute, S 171 77 Stockholm, Sweden
    Genes Dev 17:729-37. 2003
    ..These findings assign new roles for Nkx, Hox, and Phox2 proteins in the control of temporal neuronal fate determination, and link spatial and temporal patterning of CNS neuronal fates...
  10. ncbi Role of Hoxa-2 in axon pathfinding and rostral hindbrain patterning
    A Gavalas
    Institut de Genetique et de Biologie Moleculaire et Cellulaire, CNRS INSERM ULP, College de France, CU de Strasbourg
    Development 124:3693-702. 1997
    ..These results point to a novel role for Hoxa-2 in the control of r2-r3 motor axon guidance, and also suggest that its absence may lead to homeotic changes in the alar plates of these rhombomeres...
  11. ncbi A conserved retinoic acid responsive element in the murine Hoxb-1 gene is required for expression in the developing gut
    D Huang
    Department of Pharmacology, Cornell University Medical College, New York, NY 10021, USA
    Development 125:3235-46. 1998
    ....
  12. ncbi Synergy between Hoxa1 and Hoxb1: the relationship between arch patterning and the generation of cranial neural crest
    A Gavalas
    Division of Developmental Neurobiology, MRC National Institute for Medical Research, The Ridgeway, Mill Hill, London NW7 1AA, UK
    Development 128:3017-27. 2001
    Hoxa1 and Hoxb1 have overlapping synergistic roles in patterning the hindbrain and cranial neural crest cells...
  13. ncbi Cross-regulation in the mouse HoxB complex: the expression of Hoxb2 in rhombomere 4 is regulated by Hoxb1
    M K Maconochie
    Laboratory of Developmental Neurobiology, Medical Research Council MRC, National Institute for Medical Research NIMR, London, UK
    Genes Dev 11:1885-95. 1997
    ..within this enhancer, and in vitro DNA binding experiments showed that the vertebrate labial-related protein Hoxb1 will cooperatively bind to this site in a Pbx/Exd-dependent manner...
  14. doi Hoxb1 controls cell fate specification and proliferative capacity of neural stem and progenitor cells
    Mina Gouti
    Developmental Biology Laboratory, Biomedical Research Foundation of the Academy of Athens, Soranou Ephessiou 4, Athens 11527, Greece
    Stem Cells 26:1985-97. 2008
    ..We report that timely induction of a Hoxb1 transgene in ESC-derived NSCs resulted in the specification of NSCs toward a hindbrain-specific identity through ..
  15. ncbi Hox3 genes coordinate mechanisms of genetic suppression and activation in the generation of branchial and somatic motoneurons
    Gary O Gaufo
    Howard Hughes Medical Institute, Department of Human Genetics, University of Utah, Salt Lake City, UT 84112, USA
    Development 130:5191-201. 2003
    ..of any combination of the Hox3 paralogous genes results in ectopic expression of the r4-specific determinant Hoxb1. This ectopic expression in turn results in the differentiation of r4-like facial branchiomotoneurons within this ..
  16. ncbi The transcription factor GATA3 is a downstream effector of Hoxb1 specification in rhombomere 4
    I Pata
    Institute of Molecular and Cell Biology, University of Tartu, 51010 Tartu, Estonia
    Development 126:5523-31. 1999
    ..of GATA3 in ventral rhombomere (r) 4 is dependent on functional GATA2, which in turn is under the control of Hoxb1. In particular, the absence of Hoxb1 results in the loss of GATA2 expression in r4 and the absence of GATA2 ..
  17. ncbi Targeted disruption of the Hoxb-2 locus in mice interferes with expression of Hoxb-1 and Hoxb-4
    J R Barrow
    Howard Hughes Medical Institute, Department of Human Genetics, University of Utah, School of Medicine, Salt Lake City 84112, USA
    Development 122:3817-28. 1996
    ..Hoxb-2 and hoxb-4 appear to function together to mediate proper closure of the ventral thoracic body wall. Failure in this closure results in severe defects of the sternum...
  18. ncbi Expression of the mouse labial-like homeobox-containing genes, Hox 2.9 and Hox 1.6, during segmentation of the hindbrain
    P Murphy
    MRC Human Genetics Unit, Western General Hospital, Edinburgh, UK
    Development 111:61-74. 1991
    ..4) Hox 2.9 expression is confined to the region of rhombomere 4 that shows cell lineage restriction and, unlike Krox 20, is expressed throughout the period that rhombomeres are visible (to 11 1/2 days).(ABSTRACT TRUNCATED AT 400 WORDS)..
  19. ncbi A homeotic transformation is generated in the rostral branchial region of the head by disruption of Hoxa-2, which acts as a selector gene
    F M Rijli
    Laboratoire de Génétique Moléculaire des Eucaryotes du Centre National de la Recherche Scientifique Unité, Institut de Chimie Biologique Faculté de Médecine
    Cell 75:1333-49. 1993
    ..The ground pattern program appears to be modified in the mouse first arch by a Hox-independent process, whereas Hoxa-2 acts as a selector gene in the second arch...
  20. ncbi Loss of Hox-A1 (Hox-1.6) function results in the reorganization of the murine hindbrain
    E M Carpenter
    Howard Hughes Medical Institute, Department of Human Genetics, University of Utah School of Medicine, Salt Lake City 84112
    Development 118:1063-75. 1993
    ....
  21. ncbi A conserved retinoic acid response element required for early expression of the homeobox gene Hoxb-1
    H Marshall
    Laboratory of Developmental Neurobiology, National Institute for Medical Research, London, UK
    Nature 370:567-71. 1994
    ..Point mutations in the RARE abolish expression in neuroectoderm. Therefore, this RARE is not only involved in the ectopic response to retinoic acid, but is also essential for establishing aspects of the early Hoxb-1 expression pattern...
  22. ncbi Role of a conserved retinoic acid response element in rhombomere restriction of Hoxb-1
    M Studer
    Lab of Developmental Neurobiology, National Institute for Medical Research, Mill Hill, London, UK
    Science 265:1728-32. 1994
    ..Retinoids and their nuclear receptors may therefore participate in sharpening segment-restricted expression of Hoxb-1 during rhombomere boundary formation...
  23. ncbi Ectopic Hoxa-1 induces rhombomere transformation in mouse hindbrain
    M Zhang
    Department of Toxicology and Pathology, Roche Research Center, Hoffmann La Roche, Nutley, New Jersey 07110
    Development 120:2431-42. 1994
    ..Taken together, these data suggest that ectopic Hoxa-1 expression can reorganize select regions of the developing hindbrain by inducing partial transformations of several rhombomeres into a rhombomere-4-like identity...
  24. ncbi Reversal of axonal pathways from rhombomere 3 correlates with extra Hox expression domains
    M Kessel
    Max Planck Institut für Biophysikalische Chemie Am Fassberg, Gottingen, Germany
    Neuron 10:379-93. 1993
    ..Here r3 axons turned in the opposite direction and exited as facial nerves from r4. These changes of neuroectodermal fates indicate a linkage between axonal pathfinding and intrinsic neuronal specification by Hox codes...
  25. ncbi Exogenous retinoic acid rapidly induces anterior ectopic expression of murine Hox-2 genes in vivo
    R A Conlon
    Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Toronto, Ontario, Canada
    Development 116:357-68. 1992
    ....
  26. ncbi Reversal of Hox1 gene subfunctionalization in the mouse
    Petr Tvrdik
    Howard Hughes Medical Institute, University of Utah, 15 North 2030 East, Salt Lake City, Utah 84112, USA
    Dev Cell 11:239-50. 2006
    In vertebrates, paralogous Hox genes play diverse biological roles. We examined the interchangeability of Hoxa1 and Hoxb1 in mouse development by swapping their protein-coding regions...
  27. ncbi Disruption of Krox-20 results in alteration of rhombomeres 3 and 5 in the developing hindbrain
    S Schneider-Maunoury
    Unité 368 de l Institut National de la Santé et de la Recherche Médicale, Biologie Moléculaire du Développement, Ecole Normale Superieure, Paris, France
    Cell 75:1199-214. 1993
    ..We conclude that Krox-20, although not required for the initial delimitation of r3 and r5, plays an important role in the process of segmentation governing hindbrain development...
  28. ncbi Expression and genetic interaction of transcription factors GATA-2 and GATA-3 during development of the mouse central nervous system
    J Nardelli
    Cytosquelette et Développement, CNRS URA 2115, CHU Pitie Salpetriere, 105 Boulevard de l Hôpital, Paris Cedex, 75 634, France
    Dev Biol 210:305-21. 1999
    ....
  29. ncbi Transcriptional repression coordinates the temporal switch from motor to serotonergic neurogenesis
    John Jacob
    Developmental Neurobiology, National Institute for Medical Research, The Ridgeway, Mill Hill, London NW7 1AA, UK
    Nat Neurosci 10:1433-9. 2007
    ..Moreover, the subsequent differentiation of central serotonergic neurons required both the suppression of VMN neurogenesis and the induction of downstream intrinsic determinants of serotonergic identity by Foxa2...
  30. ncbi In vivo functional analysis of the Hoxa-1 3' retinoic acid response element (3'RARE)
    V Dupé
    Institut de Genetique et de Biologie Moleculaire et Cellulaire, CNRS INSERM ULP, College de France, Illkirch, CU de Strasbourg, France
    Development 124:399-410. 1997
    ..Interestingly, although the RARE is not required for the spatiotemporal control of colinear expression of the Hoxa genes, it is absolutely required for correct Hoxa-2 expression in rhombomere 5...
  31. ncbi Contribution of cellular retinol-binding protein type 1 to retinol metabolism during mouse development
    Nicolas Matt
    Institut de Genetique et de Biologie Moleculaire et Cellulaire IGBMC, Institut Clinique de la Souris ICS, CNRS INSERM ULP, College de France, BP10142, 67404 Illkirch Cedex, CU de Strasbourg, France
    Dev Dyn 233:167-76. 2005
    ..Therefore, CRBP1 is required in prenatal life to maintain normal amounts of ROL and to ensure its efficient storage but seems of secondary importance for RA synthesis, at least under conditions of maternal vitamin A sufficiency...
  32. pmc Loss of retinoic acid receptor gamma function in F9 cells by gene disruption results in aberrant Hoxa-1 expression and differentiation upon retinoic acid treatment
    J F Boylan
    Department of Pharmacology, Cornell University Medical College, New York, NY 10021
    Proc Natl Acad Sci U S A 90:9601-5. 1993
    ..Our results support the idea that each RAR may regulate different subsets of RA-responsive genes, which may explain, in part, the complex regulation of developmental processes by retinoids...
  33. ncbi Neuronal defects in the hindbrain of Hoxa1, Hoxb1 and Hoxb2 mutants reflect regulatory interactions among these Hox genes
    Anthony Gavalas
    Division of Developmental Neurobiology, MRC National Institute for Medical Research, The Ridgeway, Mill Hill, London NW7 1AA, UK
    Development 130:5663-79. 2003
    ..patterning in the hindbrain, we analysed neurogenesis, neuronal differentiation and motoneuron migration in Hoxa1, Hoxb1 and Hoxb2 mutant mice...
  34. ncbi Mice with targeted disruption of Hoxb-1 fail to form the motor nucleus of the VIIth nerve
    J M Goddard
    Howard Hughes Medical Institute, Department of Human Genetics, University of Utah, School of Medicine, Salt Lake City 84112, USA
    Development 122:3217-28. 1996
    ..These animals should therefore provide a useful animal model for these human diseases...
  35. ncbi HNF-3 beta is essential for node and notochord formation in mouse development
    S L Ang
    Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Toronto, Ontario, Canada
    Cell 78:561-74. 1994
    ..HNF-3 beta is not required for the development of definitive endoderm cells, but foregut morphogenesis is severely affected in HNF-3 beta -/- embryos...
  36. pmc Atypical cadherins Celsr1-3 differentially regulate migration of facial branchiomotor neurons in mice
    Yibo Qu
    Institute of Neuroscience, Developmental Neurobiology, Universite Catholique de Louvain, Brussels, Belgium
    J Neurosci 30:9392-401. 2010
    ..These data indicate that Celsr1-3 differentially regulate FBM neuron migration. Celsr1 helps to specify the direction of FBM neuron migration, whereas Celsr2 and 3 control its ability to migrate...
  37. ncbi Hoxa1 and Krox-20 synergize to control the development of rhombomere 3
    F Helmbacher
    Unité 368 de l Institut National de la Santé et de la Recherche Médicale, Ecole Normale Superieure, 75230 Paris Cedex 05, France
    Development 125:4739-48. 1998
    ..In addition, these data suggest that the control of the development of r3 may not be autonomous but dependent on interactions with Hoxa1-expressing cells...
  38. pmc Hoxb1 enhancer and control of rhombomere 4 expression: complex interplay between PREP1-PBX1-HOXB1 binding sites
    Elisabetta Ferretti
    Molecular Genetics Unit, Department of Molecular Biology and Functional Genomics, Istituto Scientifico H San Raffaele, Universita Vita Salute San Raffaele, Via Olgettina 58, 20132 Milan, Italy
    Mol Cell Biol 25:8541-52. 2005
    The Hoxb1 autoregulatory enhancer directs segmental expression in vertebrate hindbrain...
  39. ncbi Fgf3 and Fgf10 are required for mouse otic placode induction
    Tracy J Wright
    Department of Human Genetics, University of Utah, Salt Lake City, UT 84112 5330, USA
    Development 130:3379-90. 2003
    ..Finally, examination of embryos carrying three out of the four mutant Fgf alleles revealed intermediate phenotypes, suggesting a quantitative requirement for FGF signalling in otic vesicle formation...
  40. ncbi Bmp2 is required for migration but not for induction of neural crest cells in the mouse
    Ana Catarina Correia
    Instituto Gulbenkian de Ciencia, Oeiras, Portugal
    Dev Dyn 236:2493-501. 2007
    ..Finally, our data suggest that the molecular cascade downstream of BMP signaling in early neural crest development may be different in mouse and avian embryos...
  41. ncbi Acquisition of Hox codes during gastrulation and axial elongation in the mouse embryo
    Sylvie Forlani
    Hubrecht Laboratory, Netherlands Institute for Developmental Biology, Uppsalalaan 8, 3584 CT Utrecht, The Netherlands
    Development 130:3807-19. 2003
    ..The ability to express autonomously the earliest Hox gene, Hoxb1, is present in the posterior streak region at the onset of gastrulation, but not in the anterior region at this ..
  42. pmc MeCP2 is critical within HoxB1-derived tissues of mice for normal lifespan
    Christopher S Ward
    Jan and Dan Duncan Neurological Research Institute, Houston, Texas 77030, USA
    J Neurosci 31:10359-70. 2011
    ....
  43. pmc Distinct functions of the major Fgf8 spliceform, Fgf8b, before and during mouse gastrulation
    Qiuxia Guo
    Department of Genetics and Developmental Biology, University of Connecticut Health Center, 263 Farmington Avenue, Farmington, CT 06030, USA
    Development 134:2251-60. 2007
    ....
  44. ncbi CYP26A1 and CYP26C1 cooperatively regulate anterior-posterior patterning of the developing brain and the production of migratory cranial neural crest cells in the mouse
    Masayuki Uehara
    Developmental Genetics Group, Graduate School of Frontier Biosciences, Osaka University, Osaka 565 0871, Japan
    Dev Biol 302:399-411. 2007
    ....
  45. pmc Hox genes define distinct progenitor sub-domains within the second heart field
    Nicolas Bertrand
    Laboratoire de Génétique Médicale et Génomique Fonctionnelle, Inserm UMR_S910, Universite d Aix Marseille, 27 Bd Jean Moulin, 13005 Marseille, France
    Dev Biol 353:266-74. 2011
    ..We have previously shown that Retinoic Acid (RA) signal participates to this patterning. We now show that Hoxb1, Hoxa1, and Hoxa3, as downstream RA targets, are expressed in distinct sub-domains within the SHF...
  46. pmc Loss of function but no gain of function caused by amino acid substitutions in the hexapeptide of Hoxa1 in vivo
    Sophie Remacle
    Unit of Developmental Genetics, Universite Catholique de Louvain, Brussels, Belgium
    Mol Cell Biol 24:8567-75. 2004
    ....
  47. pmc Retinoic acid regulates differentiation of the secondary heart field and TGFbeta-mediated outflow tract septation
    Peng Li
    Broad Center for Regenerative Medicine and Stem Cell Research, University of Southern California Keck School of Medicine, Los Angeles, CA 90033, USA
    Dev Cell 18:480-5. 2010
    ..This may be a common pathogenic pathway when second heart field and septation defects are coupled...
  48. ncbi Differential expression of Sonic hedgehog along the anterior-posterior axis regulates patterning of pharyngeal pouch endoderm and pharyngeal endoderm-derived organs
    Billie A Moore-Scott
    Institute for Molecular Medicine and Genetics, Medical College of Georgia, Augusta, GA 30912, USA
    Dev Biol 278:323-35. 2005
    ..Our data suggest that, as in the posterior gut endoderm, exclusion of Shh expression from developing primordia is required for the proper development of pharyngeal-derived organs...
  49. pmc FGF8 initiates inner ear induction in chick and mouse
    Raj K Ladher
    Sensory Development, RIKEN Center for Developmental Biology, Chuo Ku, Kobe 650 0047, Japan
    Genes Dev 19:603-13. 2005
    ..Thus, Fgf8 plays a critical upstream role in an FGF signaling cascade required for otic induction in chick and mouse...
  50. pmc Involvement of retinol dehydrogenase 10 in embryonic patterning and rescue of its loss of function by maternal retinaldehyde treatment
    Muriel Rhinn
    Institut de Genetique et de Biologie Moleculaire et Cellulaire, Illkirch F 67404, France
    Proc Natl Acad Sci U S A 108:16687-92. 2011
    ..These results underscore the importance of maternal retinoids in preventing congenital birth defects, and lead to a revised model of the importance of RDH10 and RALDHs in controlling embryonic RA distribution...
  51. pmc Growth differentiation factor 11 signals through the transforming growth factor-beta receptor ALK5 to regionalize the anterior-posterior axis
    Olov Andersson
    Department of Neuroscience, Division of Molecular Neurobiology, Karolinska Institutet, Berzelius vag 35, Box 285, 17177 Stockholm, Sweden
    EMBO Rep 7:831-7. 2006
    ..Thus, the transforming growth factor-beta (TGF-beta) receptor ALK5, which until now has only been associated with the biological functions of TGF-beta1 to TGF-beta3 proteins, mediates GDF11 signalling during embryogenesis...
  52. ncbi Nuclear re-organisation of the Hoxb complex during mouse embryonic development
    Séverine Chambeyron
    MRC Human Genetics Unit, Crewe Road, Edinburgh EH4 2XU, UK
    Development 132:2215-23. 2005
    ..The first changes in chromatin structure and nuclear organisation were detected during gastrulation in the Hoxb1-expressing posterior primitive streak region: Hoxb chromatin was decondensed and the Hoxb1 locus looped out from ..
  53. ncbi Dissecting Wnt/beta-catenin signaling during gastrulation using RNA interference in mouse embryos
    Heiko Lickert
    Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Toronto M5G 1X5, Canada
    Development 132:2599-609. 2005
    ..This functional genomic approach allows the rapid identification of functionally important components of embryonic development from large datasets of putative targets...
  54. pmc Notch signaling augments the canonical Wnt pathway to specify the size of the otic placode
    Chathurani S Jayasena
    Gonda Department of Cell and Molecular Biology, House Ear Institute, 2100 West 3rd Street, Los Angeles, CA 90057, USA
    Development 135:2251-61. 2008
    ....
  55. pmc Tbx3 is required for outflow tract development
    Karim Mesbah
    Developmental Biology Institute of Marseilles Luminy, France
    Circ Res 103:743-50. 2008
    ....
  56. pmc Plasticity of neural crest-placode interaction in the developing visceral nervous system
    Yiju Chen
    Department of Biology, University of Texas at San Antonio, San Antonio, Texas 78249, USA
    Dev Dyn 240:1880-8. 2011
    ..The ability of NC and placodal cells to, respectively, differentiate and migrate despite a positional mismatch along the A/P axis reflects the plasticity in the relationship between the two neurogenic precursors of the vertebrate head...
  57. ncbi Requirement for tumor suppressor Apc in the morphogenesis of anterior and ventral mouse embryo
    Tomo o Ishikawa
    Department of Pharmacology, Graduate School of Medicine, Kyoto University, Kyoto, 606 8501, Japan
    Dev Biol 253:230-46. 2003
    ..Our results provide genetic evidence that expression of Apc at the normal level is essential for both anterior and ventral development, in the epiblast derivatives and visceral endoderm...
  58. ncbi Expression of Hoxb genes in the developing mouse foregut and lung
    C W Bogue
    Department of Pediatrics, Yale University School of Medicine, New Haven, Connecticut 06520 8064, USA
    Am J Respir Cell Mol Biol 15:163-71. 1996
    ....
  59. ncbi The role of kreisler in segmentation during hindbrain development
    M Manzanares
    Division of Developmental Neurobiology, MRC National Institute for Medical Research, The Ridgeway, Mill Hill, London, NW7 1AA, United Kingdom
    Dev Biol 211:220-37. 1999
    ..We conclude that the mouse kreisler gene regulates multiple steps in segmental patterning involving both the formation of segments and their A-P identity...
  60. ncbi Segmental and neuronal architecture of the hindbrain of Krox-20 mouse mutants
    S Schneider-Maunoury
    Unité 368 de l Institut National de la Santé et de la Recherche Médicale, Biologie Moléculaire du Développement, Ecole Normale Superieure, Paris, France
    Development 124:1215-26. 1997
    ..This navigational error could explain the disappearance, at around 17.5 dpc, of the trigeminal motor nucleus in Krox-20(-/-) embryos by inadequate supply of essential, possibly arch-specific survival factors...
  61. ncbi Krox-20 is a key regulator of rhombomere-specific gene expression in the developing hindbrain
    T Seitanidou
    Unité 368 de l Institut National de la Santé et de la Recherche Médicale, Biologie Moléculaire du Développement, Ecole Normale Superieure, Paris, France
    Mech Dev 65:31-42. 1997
    ....
  62. ncbi The transcription factor HNF3beta is required in visceral endoderm for normal primitive streak morphogenesis
    D Dufort
    Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Toronto, Ontario, Canada, M5G 1X5
    Development 125:3015-25. 1998
    ..We show that such mutant embryos lack foregut and midgut endoderm. In addition, left-right asymmetry is affected in the mutant embryos...
  63. ncbi Expression of homeobox genes, including an insulin promoting factor, in the murine yolk sac at the time of hematopoietic initiation
    K E McGrath
    Department of Pediatrics, University of Rochester Medical Center, NY 14642, USA
    Mol Reprod Dev 48:145-53. 1997
    ..We hypothesize the early expression of insulin in the YS is required for the expansion of insulin responsive cells including primitive erythroblasts...
  64. ncbi Sequential roles for Otx2 in visceral endoderm and neuroectoderm for forebrain and midbrain induction and specification
    M Rhinn
    Institut de Genetique et de Biologie Moleculaire et Cellulaire, CNRS INSERM Universite Louis Pasteur, Strasbourg, France
    Development 125:845-56. 1998
    ..Altogether, these results demonstrate that Otx2 is first required in the visceral endoderm for the induction, and subsequently in the neuroectoderm for the specification of forebrain and midbrain territories...
  65. ncbi Mesodermal defects and cranial neural crest apoptosis in alpha5 integrin-null embryos
    K L Goh
    Center for Cancer Research and Department of Biology, Massachusetts Institute of Technology, Cambridge 02139, USA
    Development 124:4309-19. 1997
    ....
  66. ncbi Targeted disruption of the mouse homologue of the Drosophila polyhomeotic gene leads to altered anteroposterior patterning and neural crest defects
    Y Takihara
    Department of Medical Genetics, Research Institute for Microbial Diseases, Osaka University, Suita, Japan
    Development 124:3673-82. 1997
    ..These results indicate that the rae28 gene is involved in the regulation of Hox gene expression and segment specification during paraxial mesoderm and neural crest development...
  67. ncbi Retinoic acid synthesis and hindbrain patterning in the mouse embryo
    K Niederreither
    Institut de Genetique et de Biologie Moleculaire et Cellulaire, CNRS INSERM ULP College de France, CU de Strasbourg
    Development 127:75-85. 2000
    ..Instead of forming a defined r4, Hoxb1- and Wnt8A-expressing cells are scattered throughout the caudal hindbrain, whereas r5/r8 markers such as kreisler ..
  68. ncbi Perinatal lethality and defects in hindbrain development in mice homozygous for a targeted mutation of the zinc finger gene Krox20
    P J Swiatek
    Roche Institute of Molecular Biology, Roche Research Center, Nutley, New Jersey 07110
    Genes Dev 7:2071-84. 1993
    ..These data demonstrate that Krox20 plays an essential role during development of the hindbrain and associated cranial sensory ganglia in mice...
  69. ncbi Isolation of the mouse Hox-2.9 gene; analysis of embryonic expression suggests that positional information along the anterior-posterior axis is specified by mesoderm
    M A Frohman
    Department of Anatomy, School of Medicine, University of California, San Francisco 94143
    Development 110:589-607. 1990
    ..e. anteroposterior positional information is acquired by mesoderm, mesoderm induces positional values within (neuro-) ectoderm and endoderm, and both events occur within a restricted window of time...
  70. pmc Fgfr1 regulates patterning of the pharyngeal region
    Nina Trokovic
    Institute of Biotechnology, Viikki Biocenter, 00014 University of Helsinki, Finland
    Genes Dev 17:141-53. 2003
    ..Our results indicate that Fgfr1 patterns the pharyngeal region to create a permissive environment for neural crest cell migration...
  71. ncbi Several receptor tyrosine kinase genes of the Eph family are segmentally expressed in the developing hindbrain
    N Becker
    Unité INSERM 368, Ecole Normale Superieure, Paris, France
    Mech Dev 47:3-17. 1994
    ..1992; Nieto et al., 1992), these data indicate that members of the Eph family of RTKs may co-operate in the segmental patterning of the hindbrain...
  72. ncbi Normal fate and altered function of the cardiac neural crest cell lineage in retinoic acid receptor mutant embryos
    Xiaobing Jiang
    Institute for Genetic Medicine, University of Southern California Keck School of Medicine, 2250 Alcazar St, IGM240, Los Angeles, CA 90033, USA
    Mech Dev 117:115-22. 2002
    ..This suggests that an alternative tissue in the vicinity of the outflow tract of the heart responds directly to RA, and thereby induces or permits the neural crest cell lineage to initiate aorticopulmonary septation...
  73. ncbi The mouse segmentation gene kr encodes a novel basic domain-leucine zipper transcription factor
    S P Cordes
    Department of Pediatrics, Stanford University, California 94305
    Cell 79:1025-34. 1994
    ..The identity, expression, and mutant phenotype of kr indicate an early role in axial patterning and provide insights into the molecular and embryologic mechanisms that govern hindbrain and otic development...
  74. ncbi Analysis of two distinct retinoic acid response elements in the homeobox gene Hoxb1 in transgenic mice
    Danyang Huang
    Department of Pharmacology, Weill Medical College of Cornell University, 1300 York Avenue, New York, NY 10021, USA
    Dev Dyn 223:353-70. 2002
    ..Previously, two RAREs located 3' of the murine Hoxb1 gene, a DR(2) RARE and a DR(5) RARE, have been shown to regulate Hoxb1 mRNA expression in the neural epithelium ..
  75. ncbi Expression of class I homeobox genes in fetal and adult murine skin
    K Detmer
    San Francisco VA Medical Center, CA 94121
    J Invest Dermatol 101:517-22. 1993
    ..The amount of Hoxb-4, -b-2, and -c-4 message in skin is relatively constant from the earliest gestational day examined (day 16) through birth at day 19. Expression of several homeobox genes is also seen in adult skin...
  76. ncbi Localized and transient transcription of Hox genes suggests a link between patterning and the segmentation clock
    J Zakany
    Department of Zoology and Animal Biology, University of Geneva, Sciences III, Quai Ernest Ansermet 30, 1211 Geneva 4, Switzerland
    Cell 106:207-17. 2001
    ..These results suggest a molecular link between Hox gene activation and the segmentation clock. Such a linkage would efficiently keep in phase the production of novel segments with their morphological specification...
  77. ncbi Roles of retinoic acid receptors in early embryonic morphogenesis and hindbrain patterning
    O Wendling
    Institut de Genetique et de Biologie Moleculaire et Cellulaire IGBMC, CNRS INSERM ULP College de France, B P 163, 67404 Illkirch Cedex, C U de Strasbourg, France
    Development 128:2031-8. 2001
    ....
  78. pmc Minimization of exogenous signals in ES cell culture induces rostral hypothalamic differentiation
    Takafumi Wataya
    Organogenesis and Neurogenesis Group and Division of Human Stem Cell Technology, RIKEN Center for Developmental Biology, Kobe 650 0047, Japan
    Proc Natl Acad Sci U S A 105:11796-801. 2008
    ..These findings indicate that, instead of the addition of inductive signals, minimization of exogenous patterning signaling plays a key role in rostral hypothalamic specification of neural progenitors derived from pluripotent cells...
  79. ncbi A targeted mouse Otx2 mutation leads to severe defects in gastrulation and formation of axial mesoderm and to deletion of rostral brain
    S L Ang
    Institute de Genetique et de Biologie Moleculaire et Cellulaire, CNRS INSERM Universite Louis Pasteur, Illkirch, C U de Strasbourg, France
    Development 122:243-52. 1996
    ....
  80. ncbi Pbx3 is required for normal locomotion and dorsal horn development
    Catherine A Rottkamp
    Department of Neurosciences, Rm E640, Case School of Medicine, Cleveland, OH 44106, USA
    Dev Biol 314:23-39. 2008
    ..Loss of Pbx3 function thus leads to the incorrect specification of some glutamatergic neurons in the dorsal horn and alters the integration of peripheral sensation into the spinal circuitry regulating locomotion...
  81. ncbi Analysis of hindbrain patterning defects caused by the kreisler(enu) mutation reveals multiple roles of Kreisler in hindbrain segmentation
    Virginia S Sadl
    Samuel Lunenfeld Research Institute, Mt Sinai Hospital, Toronto, Ontario, Canada
    Dev Dyn 227:134-42. 2003
    ..We determined that the kr chromosomal inversion caused ectopic Kreisler expression in r3 of kr/kr and kr/+ embryos. Hence, Kreisler regulates maintenance and expansion of r5 and specification of r6 but is not required for r3 development...
  82. ncbi Hox cluster polarity in early transcriptional availability: a high order regulatory level of clustered Hox genes in the mouse
    Bernard A J Roelen
    Hubrecht Laboratory, Netherlands Institute for Developmental Biology, Uppsalalaan 8, 3584 CT, Utrecht, The Netherlands
    Mech Dev 119:81-90. 2002
    ..prior to initial expression of the first Hox gene, a dramatic transcriptional stimulation of the 3'most genes, Hoxb1 and Hoxb2, is observed upon a short pulse of exogenous retinoic acid (RA), whereas it is not in the case for more ..
  83. ncbi Region of caspase-3 activation and programmed cell death in the early development of the mouse forebrain
    Koko Urase
    Division of Development and Differentiation, National Institute of Neuroscience, NCNP, Kodaira, Tokyo 187 8502, Japan
    Brain Res Dev Brain Res 145:241-8. 2003
    ..Thus, it is likely that decreased cell death in the ventral forebrain of caspase-3- and caspase-9-deficient 129/Sv mice increases the number of neuroprogenitor cells in the MGE, leading to hyperplasia of the forebrain...
  84. ncbi Regulation of Hoxb3 expression in the hindbrain and pharyngeal arches by rae28, a member of the mammalian Polycomb group of genes
    D Tomotsune
    Department of Medical Genetics, Research Institute for Microbial Diseases, Osaka University, 3 1 Yamadaoka, Suita, 565 0871, Osaka, Japan
    Mech Dev 98:165-9. 2000
    ..Our results suggest that rae28 is not required for the establishment but maintenance of Hoxb3 expression...
  85. ncbi The zinc finger transcriptional repressor Blimp1/Prdm1 is dispensable for early axis formation but is required for specification of primordial germ cells in the mouse
    Stephane D Vincent
    Department of Molecular and Cellular Biology, Harvard University, Cambridge, MA 02138, USA
    Development 132:1315-25. 2005
    ..Thus Blimp1 probably acts to turn off the default pathway that allows epiblast cells to adopt a somatic cell fate, and shifts the transcriptional program so that they become exclusively allocated into the germ cell lineage...
  86. ncbi Key roles of retinoic acid receptors alpha and beta in the patterning of the caudal hindbrain, pharyngeal arches and otocyst in the mouse
    V Dupé
    Institut de Genetique et de Biologie Moleculaire et Cellulaire IGBMC, CNRS INSERM ULP College de France, B P 163, CU de Strasbourg, France
    Development 126:5051-9. 1999
    ....
  87. ncbi Mice mutant for both Hoxa1 and Hoxb1 show extensive remodeling of the hindbrain and defects in craniofacial development
    M Rossel
    Howard Hughes Medical Institute, Department of Human Genetics, University of Utah School of Medicine, Salt Lake City, Utah 84112, USA
    Development 126:5027-40. 1999
    The analysis of mice mutant for both Hoxa1 and Hoxb1 suggests that these two genes function together to pattern the hindbrain. Separately, mutations in Hoxa1 and Hoxb1 have profoundly different effects on hindbrain development...
  88. ncbi The winged helix transcription factor Hfh2 is expressed in neural crest and spinal cord during mouse development
    P A Labosky
    Department of Cell and Developmental Biology, University of Pennsylvania School of Medicine, 36th and Hamilton Walk, Philadelphia, PA 19104 6058, USA
    Mech Dev 76:185-90. 1998
    ..Using linkage analysis we have localized the Hfh2 gene to chromosome 4 at 44.91 cM from the centromere...
  89. ncbi Dose-dependent interaction of Tbx1 and Crkl and locally aberrant RA signaling in a model of del22q11 syndrome
    Deborah L Guris
    The Ben May Institute for Cancer Research and Center for Molecular Oncology, The University of Chicago, Chicago, Illinois 60637, USA
    Dev Cell 10:81-92. 2006
    ..Thus, we suggest that del22q11 is a contiguous gene syndrome involving dose-sensitive interaction of CRKL and TBX1 and locally aberrant RA signaling...
  90. ncbi Hoxa1 and Hoxb1 synergize in patterning the hindbrain, cranial nerves and second pharyngeal arch
    A Gavalas
    Institut de Génétique et de Biologie Moléculaire and Cellulaire, CNRS INSERM ULP, College de France, BP 163 67404 Illkirch Cedex, CU de Strasbourg, France
    Development 125:1123-36. 1998
    The analysis of Hoxa1 and Hoxb1 null mutants suggested that these genes are involved in distinct aspects of hindbrain segmentation and specification. Here we investigate the possible functional synergy of the two genes...
  91. ncbi Defects in brain patterning and head morphogenesis in the mouse mutant Fused toes
    Isabelle Anselme
    Biologie du Développement, CNRS UMR7622, Universite Pierre et Marie Curie, 9 quai Saint Bernard, 75252 Paris Cedex 05, France
    Dev Biol 304:208-20. 2007
    ..Given the diversity, localisation and nature of the defects, we propose that some of them are caused by the elimination of the IrxB cluster, while others result from the loss of one or several of the Fts, Ftm and Fto genes...
  92. ncbi Genetic evidence that oxidative derivatives of retinoic acid are not involved in retinoid signaling during mouse development
    Karen Niederreither
    Institut de Genetique et de Biologie Moleculaire et Cellulaire, CNRS INSERM ULP College de France
    Nat Genet 31:84-8. 2002
    ..We provide genetic evidence that ALDH1A2 and CYP26A1 activities concurrently establish local embryonic retinoic acid levels that must be finely tuned to allow posterior organ development and to prevent spina bifida...
  93. ncbi SOX3 activity during pharyngeal segmentation is required for craniofacial morphogenesis
    Karine Rizzoti
    Division of Developmental Genetics, MRC National Institute for Medical Research, The Ridgeway, Mill Hill, London NW7 1AA, UK
    Development 134:3437-48. 2007
    ..They also give insight into the formation of pharyngeal pouches, of which little is known in vertebrates. Finally, this work introduces two new players in craniofacial development - SOX3 and SOX2...

Research Grants6

  1. Role of Gbx2 and Otx2 in the mes-met organizer function
    James Li; Fiscal Year: 2003
    ..abstract_text> ..
  2. The Role of Alternative Splicing of Fgf8 in Mouse Development
    James Li; Fiscal Year: 2007
    ..Therefore, our proposed studies should shed light on abnormal regulation of Fgf8 splicing on pathological conditions, including tumor formation in human. ..
  3. The Role of Alternative Splicing of Fgf8 in Mouse Development
    James Y H Li; Fiscal Year: 2010
    ..Therefore, our proposed studies should shed light on abnormal regulation of Fgf8 splicing on pathological conditions, including tumor formation in human. ..
  4. The role of Atoh1 in the development and function of Merkel cells
    Stephen M Maricich; Fiscal Year: 2010
    ..It is hoped that this information will provide insight into a number of human diseases that affect touch sensation. ..