Hoxa2

Summary

Gene Symbol: Hoxa2
Description: homeobox A2
Alias: AI324701, HOX1.11, Hox-1.11, homeo box A2, homeobox protein Hox-1.11, homeobox protein Hox-A2
Species: mouse

Top Publications

  1. ncbi Temporal requirement of Hoxa2 in cranial neural crest skeletal morphogenesis
    Fabio Santagati
    Institut de Genetique et de Biologie Moleculaire et Cellulaire, CNRS INSERM ULP, UMR 7104, BP 10142, CU de Strasbourg, 67404 Illkirch Cedex, France
    Development 132:4927-36. 2005
  2. pmc An ultraconserved Hox-Pbx responsive element resides in the coding sequence of Hoxa2 and is active in rhombomere 4
    Xavier Lampe
    Unit of Developmental Genetics, Universite Catholique de Louvain, 1200 Brussels, Belgium, Institut de Genetique et de Biologie Moleculaire et Cellulaire, UMR 7104 CNRS Inserm ULP, College de France, BP 10142 CU de Strasbourg, 67404 Illkirch Cedex, France
    Nucleic Acids Res 36:3214-25. 2008
  3. ncbi Hoxa2- and rhombomere-dependent development of the mouse facial somatosensory map
    Franck Oury
    Institut de Genetique et de Biologie Moleculaire et Cellulaire, CNRS INSERM Universite Louis Pasteur, UMR 7104, BP 10142, Communaute Urbaine de Strasbourg, 67404 Illkirch Cedex, France
    Science 313:1408-13. 2006
  4. pmc Hox paralog group 2 genes control the migration of mouse pontine neurons through slit-robo signaling
    Marc J Geisen
    Institut de Genetique et de Biologie Moleculaire et Cellulaire, CNRS INSERM ULP, UMR 7104, CU de Strasbourg, Illkirch, France
    PLoS Biol 6:e142. 2008
  5. ncbi Fate-mapping the mammalian hindbrain: segmental origins of vestibular projection neurons assessed using rhombomere-specific Hoxa2 enhancer elements in the mouse embryo
    Massimo Pasqualetti
    Institut de Genetique et de Biologie Moleculaire et Cellulaire, Centre National de la Recherche Scientifique Inserm Université Louis Pasteur, Unite Mixte de Recherche 7104, Commanaute Urbaine de Strasbourg, 67404 Illkirch Cedex, France
    J Neurosci 27:9670-81. 2007
  6. doi Hoxa2 plays a direct role in murine palate development
    Tara M Smith
    Laboratory of Molecular Biology, College of Pharmacy and Nutrition, University of Saskatchewan, Saskatoon, Saskatchewan, Canada
    Dev Dyn 238:2364-73. 2009
  7. doi Six2 functions redundantly immediately downstream of Hoxa2
    Eva Kutejova
    Department of Developmental Biology, Max Planck Institute of Immunobiology, Freiburg, Germany
    Development 135:1463-70. 2008
  8. ncbi Hoxa-2 restricts the chondrogenic domain and inhibits bone formation during development of the branchial area
    B Kanzler
    Max Planck Institute of Immunobiology, Stubeweg 51, Germany
    Development 125:2587-97. 1998
  9. ncbi A Hoxa2 knockin allele that expresses EGFP upon conditional Cre-mediated recombination
    Massimo Pasqualetti
    Institut de Genetique et de Biologie Moleculaire et Cellulaire, CNRS INSERM ULP, College de France, Strasbourg, France
    Genesis 32:109-11. 2002
  10. doi Expressing Hoxa2 across the entire endochondral skeleton alters the shape of the skeletal template in a spatially restricted fashion
    Sara Tavella
    Dipartimento di Oncologia, Biologia e Genetica, Universita di Genova, Italy
    Differentiation 79:194-202. 2010

Scientific Experts

  • A J Durston
  • Stephen O'Gorman
  • Fabrice Chatonnet
  • Guangjie Cheng
  • Karine Rizzoti
  • René Rezsohazy
  • Moises Mallo
  • R Krumlauf
  • Cecilia B Moens
  • JAMES YH LI
  • Nathalie Coré
  • A K Voss
  • Bradley E Bernstein
  • Filippo M Rijli
  • Massimo Pasqualetti
  • Nicoletta Bobola
  • Lilianna Solnica Krezel
  • Shu Yue Ren
  • Xavier Lampe
  • Eva Kutejova
  • Pavel Kirilenko
  • P Chambon
  • Stefan Tümpel
  • M Albert Basson
  • Adil J Nazarali
  • Salvador Martinez
  • Maria Di Bonito
  • Benoit Kanzler
  • Debra Ellisor
  • F M Rijli
  • Yayoi Shikata
  • Antonio Vitobello
  • Andrew J Kueh
  • Tian Yu
  • Xiao Yan Mao
  • Graham D Brown
  • Vimla S Aggarwal
  • Sara Tavella
  • Diego Echevarria
  • Sebastien Ducret
  • J R Barrow
  • Alisha R Yallowitz
  • Tara M Smith
  • Elisabetta Ferretti
  • A Gavalas
  • Michel A Wassef
  • Marc J Geisen
  • A Nazarali
  • Laurent Massip
  • Chao Guo
  • Patrick Charnay
  • Jean Sebastien Renaud
  • Bettina Engist
  • Franck Oury
  • S Nonchev
  • Jacques J Picard
  • P Dolle
  • M Davenne
  • Samuel T Waters
  • Gergana Dobreva
  • Gail R Martin
  • M K Maconochie
  • Fabio Santagati
  • Filipa Moraes
  • Billie A Moore-Scott
  • M R Capecchi
  • Leanne M Wiedemann
  • Z Hao
  • Danette J Nicolay
  • Stephanie Brewer
  • B Kanzler
  • Nina Trokovic
  • Candace L Chi
  • M Maconochie
  • Andree Dierich
  • Emma C Collins
  • Chela T James
  • Gennaro Andolfi
  • Anna Maria Franzè
  • Yuichi Narita
  • Michele Studer
  • Luigi Sequino
  • Luis Puelles
  • M Mark
  • Marta Mancuso
  • Bice Avallone
  • Jason T Machan
  • L V Wolf
  • Caroline Rieser
  • Bettina Voelcker

Detail Information

Publications86

  1. ncbi Temporal requirement of Hoxa2 in cranial neural crest skeletal morphogenesis
    Fabio Santagati
    Institut de Genetique et de Biologie Moleculaire et Cellulaire, CNRS INSERM ULP, UMR 7104, BP 10142, CU de Strasbourg, 67404 Illkirch Cedex, France
    Development 132:4927-36. 2005
    Little is known about the spatiotemporal requirement of Hox gene patterning activity in vertebrates. In Hoxa2 mouse mutants, the hyoid skeleton is replaced by a duplicated set of mandibular and middle ear structures...
  2. pmc An ultraconserved Hox-Pbx responsive element resides in the coding sequence of Hoxa2 and is active in rhombomere 4
    Xavier Lampe
    Unit of Developmental Genetics, Universite Catholique de Louvain, 1200 Brussels, Belgium, Institut de Genetique et de Biologie Moleculaire et Cellulaire, UMR 7104 CNRS Inserm ULP, College de France, BP 10142 CU de Strasbourg, 67404 Illkirch Cedex, France
    Nucleic Acids Res 36:3214-25. 2008
    The Hoxa2 gene has a fundamental role in vertebrate craniofacial and hindbrain patterning...
  3. ncbi Hoxa2- and rhombomere-dependent development of the mouse facial somatosensory map
    Franck Oury
    Institut de Genetique et de Biologie Moleculaire et Cellulaire, CNRS INSERM Universite Louis Pasteur, UMR 7104, BP 10142, Communaute Urbaine de Strasbourg, 67404 Illkirch Cedex, France
    Science 313:1408-13. 2006
    ..Moreover, early Hoxa2 expression in neuroepithelium prevents the trigeminal nerve from ectopically projecting to the cerebellum, whereas ..
  4. pmc Hox paralog group 2 genes control the migration of mouse pontine neurons through slit-robo signaling
    Marc J Geisen
    Institut de Genetique et de Biologie Moleculaire et Cellulaire, CNRS INSERM ULP, UMR 7104, CU de Strasbourg, Illkirch, France
    PLoS Biol 6:e142. 2008
    ..Here, we show that Hoxa2 and Hoxb2 are required both intrinsically and extrinsically to maintain normal AP migration of subsets of PN, by ..
  5. ncbi Fate-mapping the mammalian hindbrain: segmental origins of vestibular projection neurons assessed using rhombomere-specific Hoxa2 enhancer elements in the mouse embryo
    Massimo Pasqualetti
    Institut de Genetique et de Biologie Moleculaire et Cellulaire, Centre National de la Recherche Scientifique Inserm Université Louis Pasteur, Unite Mixte de Recherche 7104, Commanaute Urbaine de Strasbourg, 67404 Illkirch Cedex, France
    J Neurosci 27:9670-81. 2007
    ..or the enhanced green fluorescent protein reporter genes under the transcriptional control of rhombomere-specific Hoxa2 enhancer elements were used to visualize rhombomere-derived domains...
  6. doi Hoxa2 plays a direct role in murine palate development
    Tara M Smith
    Laboratory of Molecular Biology, College of Pharmacy and Nutrition, University of Saskatchewan, Saskatoon, Saskatchewan, Canada
    Dev Dyn 238:2364-73. 2009
    The cleft palate exhibited by Hoxa2 null murine embryos has been described as being secondary to abnormalities of tongue musculature, and Hoxa2 was presumed to not play a direct role in palate development...
  7. doi Six2 functions redundantly immediately downstream of Hoxa2
    Eva Kutejova
    Department of Developmental Biology, Max Planck Institute of Immunobiology, Freiburg, Germany
    Development 135:1463-70. 2008
    ..Here, we conclusively demonstrate that Six2 is a direct downstream target of Hoxa2 in vivo and show that the ectopic expression of Six2, observed in the absence of Hoxa2, contributes to the Hoxa2 ..
  8. ncbi Hoxa-2 restricts the chondrogenic domain and inhibits bone formation during development of the branchial area
    B Kanzler
    Max Planck Institute of Immunobiology, Stubeweg 51, Germany
    Development 125:2587-97. 1998
    ..The implications of these results on the patterning of the branchial area are discussed...
  9. ncbi A Hoxa2 knockin allele that expresses EGFP upon conditional Cre-mediated recombination
    Massimo Pasqualetti
    Institut de Genetique et de Biologie Moleculaire et Cellulaire, CNRS INSERM ULP, College de France, Strasbourg, France
    Genesis 32:109-11. 2002
  10. doi Expressing Hoxa2 across the entire endochondral skeleton alters the shape of the skeletal template in a spatially restricted fashion
    Sara Tavella
    Dipartimento di Oncologia, Biologia e Genetica, Universita di Genova, Italy
    Differentiation 79:194-202. 2010
    ..To clarify these controversial effects, we overexpressed Hoxa2 across the entire developing endochondral skeleton in mouse...
  11. ncbi Retinoic acid disturbs mouse middle ear development in a stage-dependent fashion
    M Mallo
    Max Planck Institute of Immunobiology, Freiburg, Germany
    Dev Biol 184:175-86. 1997
    ..5 hr of pregnancy. Moreover, interactions between adjacent bones are not required for their proper formation. My results also suggest a Hoxa-2-mediated patterning of the otic capsule in the region where the oval window is located...
  12. ncbi Mesenchymal patterning by Hoxa2 requires blocking Fgf-dependent activation of Ptx1
    Nicoletta Bobola
    Department of Developmental Biology, Max Planck Institute of Immunobiology, Freiburg, Germany
    Development 130:3403-14. 2003
    ..To address this issue, we have analyzed how Hoxa2 specifies segmental identity in the second branchial arch...
  13. pmc Transient activation of meox1 is an early component of the gene regulatory network downstream of hoxa2
    Pavel Kirilenko
    AV Hill Building, The University of Manchester, Manchester M13 9PT, United Kingdom
    Mol Cell Biol 31:1301-8. 2011
    ..b>Hoxa2 is required for correct development of the second branchial arch, its major domain of expression...
  14. ncbi Hoxa2 downregulates Six2 in the neural crest-derived mesenchyme
    Eva Kutejova
    Department of Developmental Biology, Max Planck Institute of Immunobiology, Stuebeweg 51, 79108 Freiburg, Germany
    Development 132:469-78. 2005
    The Hoxa2 transcription factor acts during development of the second branchial arch...
  15. ncbi Role of Hoxa-2 in axon pathfinding and rostral hindbrain patterning
    A Gavalas
    Institut de Genetique et de Biologie Moleculaire et Cellulaire, CNRS INSERM ULP, College de France, CU de Strasbourg
    Development 124:3693-702. 1997
    ..These results point to a novel role for Hoxa-2 in the control of r2-r3 motor axon guidance, and also suggest that its absence may lead to homeotic changes in the alar plates of these rhombomeres...
  16. ncbi Expression of Hoxa2 in cells entering chondrogenesis impairs overall cartilage development
    Laurent Massip
    Developmental Genetics Unit, Universite Catholique de Louvain, Brussels, Belgium
    Differentiation 75:256-67. 2007
    ..to the silencing of a Hox gene, we generated transgenic mice allowing Cre-mediated conditional misexpression of Hoxa2 and induced this gene in Collagen 2 alpha 1-expressing cells committed to enter chondrogenesis...
  17. ncbi Compensatory defects associated with mutations in Hoxa1 restore normal palatogenesis to Hoxa2 mutants
    J R Barrow
    Howard Hughes Medical Institute, Department of Human Genetics, University of Utah School of Medicine, Salt Lake City, UT 84112, USA
    Development 126:5011-26. 1999
    ..The loss of Hoxa1 or Hoxa2 function affects the development of multiple neural crest-derived structures...
  18. ncbi Synergy between Hoxa1 and Hoxb1: the relationship between arch patterning and the generation of cranial neural crest
    A Gavalas
    Division of Developmental Neurobiology, MRC National Institute for Medical Research, The Ridgeway, Mill Hill, London NW7 1AA, UK
    Development 128:3017-27. 2001
    ..Furthermore, they demonstrate that early patterning of the separate components of the pharyngeal arches can proceed independently of neural crest cell migration...
  19. ncbi Segmental expression of Hoxa-2 in the hindbrain is directly regulated by Krox-20
    S Nonchev
    Division of Developmental Neurobiology, MRC National Institute for Medical Research, London, UK
    Development 122:543-54. 1996
    ..Therefore, the segmental phenotypes in the Krox-20 mutants are likely to reflect the role of Krox-20 in directly regulating multiple Hox genes...
  20. ncbi Evolutionary-conserved enhancers direct region-specific expression of the murine Hoxa-1 and Hoxa-2 loci in both mice and Drosophila
    M Frasch
    Brookdale Center for Molecular Biology, Mount Sinai Medical Center, New York, NY 10029 6574, USA
    Development 121:957-74. 1995
    ..These results suggest an evolutionary conservation between HOM-C/Hox family members, which includes a conservation of certain DNA regulatory elements and possible regulatory cascades...
  21. ncbi Roles of Hoxa1 and Hoxa2 in patterning the early hindbrain of the mouse
    J R Barrow
    Howard Hughes Medical Institute, Department of Human Genetics, University of Utah School of Medicine, Salt Lake City, UT 84112, USA
    Development 127:933-44. 2000
    ..Two of these genes, Hoxa1 and Hoxa2, have been shown to be required for proper patterning of the early mouse hindbrain and the associated neural crest...
  22. pmc Murine Hox-1.11 homeobox gene structure and expression
    D P Tan
    Laboratory of Biochemical Genetics, National Heart Lung and Blood Institute, National Institutes of Health, Bethesda, MD 20892
    Proc Natl Acad Sci U S A 89:6280-4. 1992
    ..Hox-1.11 poly(A)+ RNA also is expressed in the VII and VIII cranial ganglia, spinal cord, spinal ganglia, larynx, lungs, vertebrae, sternum, and intestine...
  23. ncbi A homeotic transformation is generated in the rostral branchial region of the head by disruption of Hoxa-2, which acts as a selector gene
    F M Rijli
    Laboratoire de Génétique Moléculaire des Eucaryotes du Centre National de la Recherche Scientifique Unité, Institut de Chimie Biologique Faculté de Médecine
    Cell 75:1333-49. 1993
    ..The ground pattern program appears to be modified in the mouse first arch by a Hox-independent process, whereas Hoxa-2 acts as a selector gene in the second arch...
  24. ncbi In vivo functional analysis of the Hoxa-1 3' retinoic acid response element (3'RARE)
    V Dupé
    Institut de Genetique et de Biologie Moleculaire et Cellulaire, CNRS INSERM ULP, College de France, Illkirch, CU de Strasbourg, France
    Development 124:399-410. 1997
    ..Interestingly, although the RARE is not required for the spatiotemporal control of colinear expression of the Hoxa genes, it is absolutely required for correct Hoxa-2 expression in rhombomere 5...
  25. ncbi Ectopic Hoxa-1 induces rhombomere transformation in mouse hindbrain
    M Zhang
    Department of Toxicology and Pathology, Roche Research Center, Hoffmann La Roche, Nutley, New Jersey 07110
    Development 120:2431-42. 1994
    ..Taken together, these data suggest that ectopic Hoxa-1 expression can reorganize select regions of the developing hindbrain by inducing partial transformations of several rhombomeres into a rhombomere-4-like identity...
  26. ncbi Mice with targeted disruption of Hoxb-1 fail to form the motor nucleus of the VIIth nerve
    J M Goddard
    Howard Hughes Medical Institute, Department of Human Genetics, University of Utah, School of Medicine, Salt Lake City 84112, USA
    Development 122:3217-28. 1996
    ..These animals should therefore provide a useful animal model for these human diseases...
  27. ncbi Expression of Hoxa2 in rhombomere 4 is regulated by a conserved cross-regulatory mechanism dependent upon Hoxb1
    Stefan Tümpel
    Stowers Institute for Medical Research, 1000 E 50th Street, Kansas City, MO 64110, USA
    Dev Biol 302:646-60. 2007
    The Hoxa2 gene is an important component of regulatory events during hindbrain segmentation and head development in vertebrates...
  28. ncbi A Hoxa2 mutant conditional allele generated by Flp- and Cre-mediated recombination
    Shu Yue Ren
    Institut de Genetique et de Biologie Moleculaire et Cellulaire, CNRS INSERM ULP, College de France, Strasbourg, France
    Genesis 32:105-8. 2002
  29. ncbi Hoxa1 and Krox-20 synergize to control the development of rhombomere 3
    F Helmbacher
    Unité 368 de l Institut National de la Santé et de la Recherche Médicale, Ecole Normale Superieure, 75230 Paris Cedex 05, France
    Development 125:4739-48. 1998
    ..In addition, these data suggest that the control of the development of r3 may not be autonomous but dependent on interactions with Hoxa1-expressing cells...
  30. ncbi The Hoxa2 enhancer 2 contains a critical Hoxa2 responsive regulatory element
    Xavier Lampe
    Unit of Developmental Genetics, Universite Catholique de Louvain, 73 boîte 82 avenue Mounier, B 1200 Brussels, Belgium
    Biochem Biophys Res Commun 316:898-902. 2004
    ..Their identity is specified by Hox genes from paralogous groups 1-4. Hoxa2 is the only Hox gene to be expressed in the second rhombomere and the regulatory cues leading to this region-..
  31. ncbi Targeted insertion results in a rhombomere 2-specific Hoxa2 knockdown and ectopic activation of Hoxa1 expression
    Shu Yue Ren
    Institut de Genetique et de Biologie Moleculaire et Cellulaire, CNRS INSERM ULP, College de France, Illkirch Cedex, CU de Strasbourg, France
    Dev Dyn 225:305-15. 2002
    ..Here, we analysed the effects of the targeted insertion of a PGK-neo cassette in the 3' untranslated region of Hoxa2. Even at this 3' position, the insertion resulted in homozygous mutants that unexpectedly did not survive beyond 3 ..
  32. ncbi Conservation and diversity in the cis-regulatory networks that integrate information controlling expression of Hoxa2 in hindbrain and cranial neural crest cells in vertebrates
    Stefan Tümpel
    Stowers Institute, 1000 East 50th, Kansas City, Missouri 64110, USA
    Dev Biol 246:45-56. 2002
    The Hoxa2 and Hoxb2 genes are members of paralogy group II and display segmental patterns of expression in the developing vertebrate hindbrain and cranial neural crest cells...
  33. ncbi Hoxa2 and Hoxb2 control dorsoventral patterns of neuronal development in the rostral hindbrain
    M Davenne
    Institut de Genetique et de Biologie Moleculaire et Cellulaire, Centre National de la Recherche Scientifique Institut National de la Santé et de la Recherche Médicale Université Louis Pasteur, College de France, Strasbourg
    Neuron 22:677-91. 1999
    ..b>Hoxa2 and Hoxb2 differentially regulate, in a rhombomere-specific manner, the expression of several genes in broad D-V-..
  34. ncbi Hoxa-2 mutant mice exhibit homeotic transformation of skeletal elements derived from cranial neural crest
    M Gendron-Maguire
    Roche Institute of Molecular Biology, Roche Research Center, Nutley, New Jersey 07110
    Cell 75:1317-31. 1993
    ..Skeletal elements normally derived from the second arch were absent in the mutants. These data provide direct experimental evidence for the existence of a branchial Hox code...
  35. pmc Assembly of the auditory circuitry by a Hox genetic network in the mouse brainstem
    Maria Di Bonito
    Telethon Institute of Genetics and Medicine TIGEM, Naples, Italy
    PLoS Genet 9:e1003249. 2013
    ..On the other hand, Hoxa2 regulates the Rig1 axon guidance receptor and controls contralateral projections from the anterior VCN to the ..
  36. ncbi Differences in Krox20-dependent regulation of Hoxa2 and Hoxb2 during hindbrain development
    M K Maconochie
    Division of Developmental Neurobiology, MRC National Institute for Medical Research, The Ridgeway, Mill Hill, London, NW7 1AA, United Kingdom
    Dev Biol 233:468-81. 2001
    During hindbrain development, segmental regulation of the paralogous Hoxa2 and Hoxb2 genes in rhombomeres (r) 3 and 5 involves Krox20-dependent enhancers that have been conserved during the duplication of the vertebrate Hox clusters from ..
  37. pmc Genetic dissection of midbrain dopamine neuron development in vivo
    Debra Ellisor
    Department of Molecular Biology, Cell Biology and Biochemistry, Division of Biology and Medicine, Brown University, 70 Ship St, Providence, RI 02903, USA
    Dev Biol 372:249-62. 2012
    ..By placing Wnt1, Fgf8, and En1/2 in the context of their temporal requirement for MbDA neuron development, we further deciphered the developmental program underpinning MbDA neuron progenitors...
  38. doi Hox collinearity - a new perspective
    Antony J Durston
    Institute of Biology, University of Leiden, Sylvius Laboratory, Wassenaarseweg, Leiden, The Netherlands
    Int J Dev Biol 55:899-908. 2011
    ..The evidence focuses attention on interactions between Hox genes and on the vertebrate somitogenesis clock. These novel conclusions open new perspectives for the field...
  39. doi Effects of phenytoin on Satb2 and Hoxa2 gene expressions in mouse embryonic craniofacial tissue
    Xiao Yan Mao
    Cleft Lip and Palate Treatment Center, The Second Affiliated Hospital of Shantou University Medical College, Shantou, China
    Biochem Cell Biol 88:731-5. 2010
    ..Satb2-deficient mice exhibit cleft palate deformity and an up-regulation of Hoxa2 in the fronto-nasal region...
  40. ncbi SATB2 is a multifunctional determinant of craniofacial patterning and osteoblast differentiation
    Gergana Dobreva
    Max Planck Institute of Immunobiology, Department of Cellular and Molecular Immunology, 79108 Freiburg, Germany
    Cell 125:971-86. 2006
    ..In addition, SATB2 was found to repress the expression of several Hox genes including Hoxa2, an inhibitor of bone formation and regulator of branchial arch patterning...
  41. pmc Specific regions within the embryonic midbrain and cerebellum require different levels of FGF signaling during development
    M Albert Basson
    Department of Anatomy and Program in Developmental Biology, University of California San Francisco, CA 94158, USA
    Development 135:889-98. 2008
    ..We suggest a molecular explanation for this phenomenon by providing evidence that FGF signaling functions to inhibit the BMP signaling that promotes roof plate development...
  42. pmc Sprouty genes prevent excessive FGF signalling in multiple cell types throughout development of the cerebellum
    Tian Yu
    Department of Craniofacial Development, King s College London, London, UK
    Development 138:2957-68. 2011
    ..Taken together, our data demonstrate that FGF signalling levels have to be tightly controlled throughout cerebellar development in order to maintain the normal development of multiple cell types...
  43. pmc Hox and Pbx factors control retinoic acid synthesis during hindbrain segmentation
    Antonio Vitobello
    Friedrich Miescher Institute for Biomedical Research, Basel, Switzerland
    Dev Cell 20:469-82. 2011
    ..These findings reveal a feed-forward mechanism linking Hox-Pbx-dependent RA synthesis during early axial patterning with the establishment of spatially restricted Hox-Pbx activity in the developing hindbrain...
  44. pmc HBO1 is required for H3K14 acetylation and normal transcriptional activity during embryonic development
    Andrew J Kueh
    The Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria, Australia
    Mol Cell Biol 31:845-60. 2011
    ..In conclusion, the primary role of HBO1 in development is that of a transcriptional activator, which is indispensable for H3K14 acetylation and for the normal expression of essential genes regulating embryonic development...
  45. ncbi Tshz1 is required for axial skeleton, soft palate and middle ear development in mice
    Nathalie Coré
    Institut de Biologie du Developpement de Marseille Luminy IBDML, UMR6216, CNRS, Universite de la Mediterranee, F 13288 Marseille Cedex 09, France
    Dev Biol 308:407-20. 2007
    ..Finally, we demonstrate that Tshz1 is required for the development of the soft palate...
  46. doi Ptch1-mediated dosage-dependent action of Shh signaling regulates neural progenitor development at late gestational stages
    Yayoi Shikata
    Brain Science Institute, RIKEN, 2 1 Hirosawa, Wako, Saitama 351 0198, Japan
    Dev Biol 349:147-59. 2011
    ..These data indicated that endogenous Ptch1 mediates the broad effects of Shh on the transition from VZ progenitors to IPCs and activation of proliferation of the IPCs in the cortex during late gestational stages...
  47. pmc Distinct roles of Hoxa2 and Krox20 in the development of rhythmic neural networks controlling inspiratory depth, respiratory frequency, and jaw opening
    Fabrice Chatonnet
    NGI, UPR 2216, Institut de Neurobiologie Alfred Fessard IFR2218, Centre National de Recherche Scientifique, F 91198 Gif sur Yvette Cedex, France
    Neural Dev 2:19. 2007
    ..Here, we compare the phenotypes of mice carrying targeted inactivations of Hoxa2, the only Hox gene expressed up to r2, and of Krox20, expressed in r3 and r5...
  48. pmc Matrix metalloproteinase-25 has a functional role in mouse secondary palate development and is a downstream target of TGF-β3
    Graham D Brown
    Laboratory of Molecular Biology, College of Pharmacy and Nutrition, University of Saskatchewan, Saskatoon, Saskatchewan S7N 5C9, Canada
    BMC Dev Biol 10:93. 2010
    ..We report on the gene expression profile of MMP-25 in the developing mouse SP and identify its functional role in mouse SP development...
  49. pmc Mesodermal Tbx1 is required for patterning the proximal mandible in mice
    Vimla S Aggarwal
    Department of Molecular Genetics, Albert Einstein College of Medicine, Bronx, NY 10461, USA
    Dev Biol 344:669-81. 2010
    ..5. This occurs without significant changes in cell proliferation or apoptosis at the same stage. Our results elucidate a new function for the non-neural crest core mesoderm and specifically, mesodermal Tbx1, in shaping the lower jaw...
  50. pmc Identification and characterization of VPO1, a new animal heme-containing peroxidase
    Guangjie Cheng
    Department of Pathology and Laboratory Medicine, Emory University School of Medicine, Atlanta, GA 30322, USA
    Free Radic Biol Med 45:1682-94. 2008
    ..5 mM. When co-expressed in cells, VPO1 can use H(2)O(2) produced by NADPH oxidase enzymes. VPO1 is likely to carry out peroxidative reactions previously attributed exclusively to myeloperoxidase in the vascular system...
  51. doi Rostral hindbrain patterning involves the direct activation of a Krox20 transcriptional enhancer by Hox/Pbx and Meis factors
    Michel A Wassef
    INSERM, U784, Laboratoire de Génétique Moléculaire du Développement and 46 rue d Ulm, 75230 Paris, France
    Development 135:3369-78. 2008
    ..We propose a model for the complex regulation of Krox20, involving a novel mode of initiation, positive and negative controls by Hox proteins, and multiple direct and indirect autoregulatory loops...
  52. ncbi Hox cofactors in vertebrate development
    Cecilia B Moens
    Division of Basic Science and HHMI, Fred Hutchinson Cancer Research Center, Seattle, WA 98115, USA
    Dev Biol 291:193-206. 2006
    ....
  53. ncbi Temporal and spatial expression of Hoxa-2 during murine palatogenesis
    A Nazarali
    Laboratory of Molecular Biology, College of Pharmacy and Nutrition, University of Saskatchewan, Saskatoon, Canada
    Cell Mol Neurobiol 20:269-90. 2000
    ..This along with our new findings of the expression of the Hoxa-2 protein during palatogenesis has shed some light on the putative role of this gene in palate development...
  54. ncbi Coordinated expression of Hoxa2, Hoxd1 and Pax6 in the developing diencephalon
    L V Wolf
    Laboratory of Molecular Biology, College of Pharmacy and Nutrition, University of Saskatchewan, Saskatoon, Canada
    Neuroreport 12:329-33. 2001
    Coordinated expression of Hoxa2, Hoxd1 and Pax6 proteins were found to coincide with the three developmental stages of the diencephalon, as described for the mouse brain...
  55. ncbi Roles of retinoic acid receptors and of Hox genes in the patterning of the teeth and of the jaw skeleton
    M Mark
    Institut de Genetique et de Biologie Moleculaire et Cellulaire, CNRS INSERM ULP, Strasbourg, France
    Int J Dev Biol 39:111-21. 1995
    ....
  56. ncbi Retinoic acid synthesis and hindbrain patterning in the mouse embryo
    K Niederreither
    Institut de Genetique et de Biologie Moleculaire et Cellulaire, CNRS INSERM ULP College de France, CU de Strasbourg
    Development 127:75-85. 2000
    ..We conclude that RA produced by the embryo is required to generate posterior cell fates in the developing mouse hindbrain, its absence leading to an abnormal r3 (and, to a lesser extent, r4) identity of the caudal hindbrain cells...
  57. ncbi Regulation of Hoxa2 in cranial neural crest cells involves members of the AP-2 family
    M Maconochie
    Laboratory of Developmental Neurobiology, National Institute for Medical Research, The Ridgeway, Mill Hill, London NW7 1AA, UK
    Development 126:1483-94. 1999
    b>Hoxa2 is expressed in cranial neural crest cells that migrate into the second branchial arch and is essential for proper patterning of neural-crest-derived structures in this region...
  58. ncbi Sequential roles for Otx2 in visceral endoderm and neuroectoderm for forebrain and midbrain induction and specification
    M Rhinn
    Institut de Genetique et de Biologie Moleculaire et Cellulaire, CNRS INSERM Universite Louis Pasteur, Strasbourg, France
    Development 125:845-56. 1998
    ..Altogether, these results demonstrate that Otx2 is first required in the visceral endoderm for the induction, and subsequently in the neuroectoderm for the specification of forebrain and midbrain territories...
  59. pmc Hox-1.11 and Hox-4.9 homeobox genes
    A Nazarali
    Laboratory of Biochemical Genetics, National Heart, Lung and Blood Institute, National Institutes of Health, Bethesda, MD 20892
    Proc Natl Acad Sci U S A 89:2883-7. 1992
    ..3 and Hox-4.2 genomic DNA revealed some differences in nucleotide sequences and in the deduced homeodomain amino acid sequences compared with the sequences that have been reported...
  60. ncbi Targeted disruption of the mouse homologue of the Drosophila polyhomeotic gene leads to altered anteroposterior patterning and neural crest defects
    Y Takihara
    Department of Medical Genetics, Research Institute for Microbial Diseases, Osaka University, Suita, Japan
    Development 124:3673-82. 1997
    ..These results indicate that the rae28 gene is involved in the regulation of Hox gene expression and segment specification during paraxial mesoderm and neural crest development...
  61. ncbi Segmental identity can change independently in the hindbrain and rhombencephalic neural crest
    M Mallo
    Max Planck Institute of Immunobiology, Freiburg, Germany
    Dev Dyn 210:146-56. 1997
    ..We propose a model for the patterning of the branchial region, according to which the segmental identity in this area is provided mainly by the branchial arches...
  62. ncbi Orientation of the Hoxa complex and placement of the Hd locus distal to Hoxa2 on mouse chromosome 6
    J W Innis
    Department of Human Genetics, Med Sci II, Ann Arbor, Michigan 48109 0618, USA
    Mamm Genome 7:216-7. 1996
  63. ncbi The expression pattern of the mouse receptor tyrosine kinase gene MDK1 is conserved through evolution and requires Hoxa-2 for rhombomere-specific expression in mouse embryos
    R Taneja
    Institut de Genetique et de Biologie Moleculaire et Cellulaire, CNRS INSERM ULP, College de France, Illkirch, C U de Strasbourg, France
    Dev Biol 177:397-412. 1996
    ....
  64. ncbi Development of the mammalian ear: coordinate regulation of formation of the tympanic ring and the external acoustic meatus
    M Mallo
    Roche Institute of Molecular Biology, Roche Research Center, Nutley, NJ 07110, USA
    Development 122:173-9. 1996
    ....
  65. pmc Local alterations of Krox-20 and Hox gene expression in the hindbrain suggest lack of rhombomeres 4 and 5 in homozygote null Hoxa-1 (Hox-1.6) mutant embryos
    P Dolle
    Laboratoire de Genetique Moleculaire des Eucaryotes, Centre National de la Recherche Scientifique, L Institut National de la Santé et de la Recherche Médicale, Strasbourg, France
    Proc Natl Acad Sci U S A 90:7666-70. 1993
    ..These alterations coincide with the region that is subsequently affected in Hoxa-1 null mutant mice and suggest that the primary defects in this mutation are spatially restricted deletions of some rhombomeric structures...
  66. ncbi Otx2 and Gbx2 are required for refinement and not induction of mid-hindbrain gene expression
    J Y Li
    Howard Hughes Medical Institute and Developmental Genetics Program, Skirball Institute of Biomolecular Medicine, New York University School of Medicine, 540 First Avenue, New York, NY 10016, USA
    Development 128:4979-91. 2001
    ..Furthermore, Otx2 and Gbx2 are required to suppress hindbrain and midbrain development, respectively, and thus allow establishment of the normal spatial domains of Fgf8 and other genes...
  67. pmc Mouse Af9 is a controller of embryo patterning, like Mll, whose human homologue fuses with Af9 after chromosomal translocation in leukemia
    Emma C Collins
    MRC Laboratory of Molecular Biology, Cambridge CB2 2QH, United Kingdom
    Mol Cell Biol 22:7313-24. 2002
    ..This is analogous to the role of Mll, the murine homolog of human MLL, to which the Af9 gene fuses in acute myeloid leukemias...
  68. ncbi New regulatory interactions and cellular responses in the isthmic organizer region revealed by altering Gbx2 expression
    James Y H Li
    Howard Hughes Medical Institute and Developmental Genetics Program, Skirball Institute of Biomolecular Medicine, New York University School of Medicine, 540 First Avenue, New York, NY 10016, USA
    Development 132:1971-81. 2005
    ..Our studies provide new insights into the regulatory interactions that maintain isthmic organizer gene expression and the consequences of altered levels of organizer gene expression on cell survival...
  69. ncbi Differential expression of Sonic hedgehog along the anterior-posterior axis regulates patterning of pharyngeal pouch endoderm and pharyngeal endoderm-derived organs
    Billie A Moore-Scott
    Institute for Molecular Medicine and Genetics, Medical College of Georgia, Augusta, GA 30912, USA
    Dev Biol 278:323-35. 2005
    ..Our data suggest that, as in the posterior gut endoderm, exclusion of Shh expression from developing primordia is required for the proper development of pharyngeal-derived organs...
  70. ncbi Tbx1 is required for proper neural crest migration and to stabilize spatial patterns during middle and inner ear development
    Filipa Moraes
    Instituto Gulbenkian de Ciencia, UT, Rua da Quinta Grande 6, 2780 156 Oeiras, Portugal
    Mech Dev 122:199-212. 2005
    ..The inability of the Tbx1(-/-) embryos to keep properly segregated functional domains in the otocyst is likely the cause of the strong inner ear phenotypes observed in these mutants...
  71. ncbi Wnt1-Cre-mediated deletion of AP-2alpha causes multiple neural crest-related defects
    Stephanie Brewer
    Department of Molecular, Cellular and Developmental Biology, Yale University, New Haven, CT 06520, USA
    Dev Biol 267:135-52. 2004
    ..These results have important implications for the evolution and function of the AP-2 gene family in both the neural crest and the vertebrate embryo...
  72. ncbi The little (lit) mutation cosegregates with the growth hormone releasing factor receptor on mouse chromosome 6
    S C Chua
    Laboratory of Human Behavior and Metabolism, Rockefeller University, New York, New York 10021
    Mamm Genome 4:555-9. 1993
    ..Molecular markers were Neuropeptide Y (Npy), homeobox (Hoxa2), immunoglobulin kappa chain (Igk), wingless-related MMTV integration site (Wnt-2), cystic fibrosis (Cftr), ..
  73. ncbi The role of Hoxa-3 in mouse thymus and thyroid development
    N R Manley
    Howard Hughes Medical Institute, Department of Human Genetics, University of Utah School of Medicine, Salt Lake City 84112, USA
    Development 121:1989-2003. 1995
    ..This variability suggests the presence of a compensating gene or genes, whose utilization is stochastic. A reasonable candidate for providing this compensatory function is the paralogous gene Hoxb-3...
  74. ncbi Tooth development is independent of a Hox patterning programme
    Chela T James
    Department of Craniofacial Development, GKT Dental Institute, Kings College London, Guy s Hospital, London Bridge, London, United Kingdom
    Dev Dyn 225:332-5. 2002
    ..However, we show that, unlike cartilage and bone, the development of teeth is not affected by alterations in Hoxa2 expression...
  75. pmc Fgfr1 regulates patterning of the pharyngeal region
    Nina Trokovic
    Institute of Biotechnology, Viikki Biocenter, 00014 University of Helsinki, Finland
    Genes Dev 17:141-53. 2003
    ..Our results indicate that Fgfr1 patterns the pharyngeal region to create a permissive environment for neural crest cell migration...
  76. ncbi SOX3 activity during pharyngeal segmentation is required for craniofacial morphogenesis
    Karine Rizzoti
    Division of Developmental Genetics, MRC National Institute for Medical Research, The Ridgeway, Mill Hill, London NW7 1AA, UK
    Development 134:3437-48. 2007
    ..They also give insight into the formation of pharyngeal pouches, of which little is known in vertebrates. Finally, this work introduces two new players in craniofacial development - SOX3 and SOX2...
  77. ncbi Lmx1b is essential for Fgf8 and Wnt1 expression in the isthmic organizer during tectum and cerebellum development in mice
    Chao Guo
    Institute of Neuroscience and Key Laboratory of Neurobiology, Shanghai Institute for Biological Sciences, Chinese Academy of Sciences, Shanghai 200031, China
    Development 134:317-25. 2007
    ....
  78. ncbi Early stages of oligodendrocyte development in the embryonic murine spinal cord proceed normally in the absence of Hoxa2
    Danette J Nicolay
    Laboratory of Molecular Biology, College of Pharmacy and Nutrition, University of Saskatchewan, Saskatoon, Saskatchewan
    Glia 48:14-26. 2004
    ..One such TF is the homeobox gene Hoxa2, which was recently shown to be expressed by O4(+) pro-oligodendrocytes...
  79. ncbi Differential expression of Hoxa-2 protein along the dorsal-ventral axis of the developing and adult mouse spinal cord
    Z Hao
    Laboratory of Molecular Biology, College of Pharmacy and Nutrition, University of Saskatchewan, Saskatoon, Canada
    Dev Dyn 216:201-17. 1999
    ..dev dyn 1999;216:201-217...
  80. doi Moz and retinoic acid coordinately regulate H3K9 acetylation, Hox gene expression, and segment identity
    Anne K Voss
    The Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria 3052, Australia
    Dev Cell 17:674-86. 2009
    ..In conclusion, our data show that Moz regulates H3K9 acetylation at Hox gene loci and that RA can act independently of Moz to establish specific Hox gene expression boundaries...
  81. ncbi A threshold requirement for Gbx2 levels in hindbrain development
    Samuel T Waters
    Laboratory of Cancer and Developmental Biology, NCI Frederick, National Institutes of Health, Frederick, MD 21702, USA
    Development 133:1991-2000. 2006
    ..As a result of this transformation, the cerebellar midline fails to form. Thus, our studies demonstrate different threshold requirements for the level of Gbx2 gene product in different regions of the hindbrain...
  82. ncbi Different levels of Hoxa2 are required for particular developmental processes
    S Ohnemus
    Max Planck Institute of Immunobiology, Stübeweg 51 79108 Freiburg, Germany
    Mech Dev 108:135-47. 2001
    b>Hoxa2 is required for a variety of developmental processes in the branchial arches and in the hindbrain. We have created a Hoxa2 allele that is about 45% as active in transcription as its wild-type counterpart...
  83. ncbi The isthmic organizer signal FGF8 is required for cell survival in the prospective midbrain and cerebellum
    Candace L Chi
    Department of Anatomy and Program in Developmental Biology, School of Medicine, University of California at San Francisco, San Francisco, CA 94143 0452, USA
    Development 130:2633-44. 2003
    ..Our data show that Fgf8 is part of a complex gene regulatory network that is essential for cell survival in the mes/met...
  84. pmc Non-homeodomain regions of Hox proteins mediate activation versus repression of Six2 via a single enhancer site in vivo
    Alisha R Yallowitz
    Department of Cell and Developmental Biology, University of Michigan, Ann Arbor, MI 48109 2200, USA
    Dev Biol 335:156-65. 2009
    ..Six2 is genetically downstream of both the Hox11 paralogous genes in the developing mammalian kidney and Hoxa2 in branchial arch and facial mesenchyme...
  85. ncbi Second branchial arch lineages of the middle ear of wild-type and Hoxa2 mutant mice
    Stephen O'Gorman
    Department of Neurosciences, School of Medicine, Case Western Reserve University, Cleveland, OH 44106, USA
    Dev Dyn 234:124-31. 2005
    ..In Hoxa2 mutant embryos, middle ear skeletal duplications occurred at sites where first and second arch elements are ..
  86. ncbi Molecular phenotype of simian virus 40 large T antigen-induced primitive neuroectodermal tumors in four different lines of transgenic mice
    K M Fung
    Department of Pathology and Laboratory Medicine, Hospital of the University of Pennsylvania, University of Pennsylvania School of Medicine, Philadelphia
    Lab Invest 70:114-24. 1994
    ..A third TGM line developed retinoblastomas (a PNET-like tumor of the retina) as well as PNETs in the mesencephalon, while the fourth TGM developed retinoblastomas and adrenal pheochromocytomas...

Research Grants21

  1. GENETIC MECHANISMS OF HINDBRAIN SEGMENTATION
    Cecilia Moens; Fiscal Year: 2009
    ..Aim 2 addresses the mechanism of plasticity. Finally, in Aim 3, we consider the mechanism by which long-range signals interact to specify the positions of specific hindbrain boundaries. ..
  2. The Role of Alternative Splicing of Fgf8 in Mouse Development
    James Y H Li; Fiscal Year: 2010
    ..Therefore, our proposed studies should shed light on abnormal regulation of Fgf8 splicing on pathological conditions, including tumor formation in human. ..
  3. The Role of Alternative Splicing of Fgf8 in Mouse Development
    James Li; Fiscal Year: 2007
    ..Therefore, our proposed studies should shed light on abnormal regulation of Fgf8 splicing on pathological conditions, including tumor formation in human. ..
  4. GENETIC MECHANISMS OF HINDBRAIN SEGMENTATION
    Cecilia Moens; Fiscal Year: 2003
    ....
  5. Role of Gbx2 and Otx2 in the mes-met organizer function
    James Li; Fiscal Year: 2003
    ..abstract_text> ..
  6. Tilling the Zebrafish Genome: A Reverse Genetic Approach
    Cecilia Moens; Fiscal Year: 2005
    ..abstract_text> ..
  7. Tilling the Zebrafish Genome: A Reverse Genetic Approach
    Lilianna Solnica Krezel; Fiscal Year: 2010
    ..We now propose to use TILLING to identify mutations in 120 genes that are of importance to biomedical research, and to make these mutants available to the zebrafish community as rapidly as possible. ..