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Genomes and Genes
| Hoxa2SummaryGene Symbol: Hoxa2 Description: homeobox A2 Alias: AI324701, HOX1.11, Hox-1.11, homeo box A2, homeobox protein Hox-1.11, homeobox protein Hox-A2 Species: mouse Top Publications
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Publications
Evolutionary-conserved enhancers direct region-specific expression of the murine Hoxa-1 and Hoxa-2 loci in both mice and DrosophilaM Frasch
Brookdale Center for Molecular Biology, Mount Sinai Medical Center, New York, NY 10029 6574, USA
Development 121:957-74. 1995..These results suggest an evolutionary conservation between HOM-C/Hox family members, which includes a conservation of certain DNA regulatory elements and possible regulatory cascades...- Hoxa2 and Hoxb2 control dorsoventral patterns of neuronal development in the rostral hindbrainM Davenne
Institut de Genetique et de Biologie Moleculaire et Cellulaire, Centre National de la Recherche Scientifique Institut National de la Santé et de la Recherche Médicale Université Louis Pasteur, College de France, Strasbourg
Neuron 22:677-91. 1999..b>Hoxa2 and Hoxb2 differentially regulate, in a rhombomere-specific manner, the expression of several genes in broad D-V-.. - Mice with targeted disruption of Hoxb-1 fail to form the motor nucleus of the VIIth nerveJ M Goddard
Howard Hughes Medical Institute, Department of Human Genetics, University of Utah, School of Medicine, Salt Lake City 84112, USA
Development 122:3217-28. 1996..These animals should therefore provide a useful animal model for these human diseases... - In vivo functional analysis of the Hoxa-1 3' retinoic acid response element (3'RARE)V Dupé
Institut de Genetique et de Biologie Moleculaire et Cellulaire, CNRS INSERM ULP, College de France, Illkirch, CU de Strasbourg, France
Development 124:399-410. 1997..Interestingly, although the RARE is not required for the spatiotemporal control of colinear expression of the Hoxa genes, it is absolutely required for correct Hoxa-2 expression in rhombomere 5... - Temporal requirement of Hoxa2 in cranial neural crest skeletal morphogenesisFabio Santagati
Institut de Genetique et de Biologie Moleculaire et Cellulaire, CNRS INSERM ULP, UMR 7104, BP 10142, CU de Strasbourg, 67404 Illkirch Cedex, France
Development 132:4927-36. 2005Little is known about the spatiotemporal requirement of Hox gene patterning activity in vertebrates. In Hoxa2 mouse mutants, the hyoid skeleton is replaced by a duplicated set of mandibular and middle ear structures... - A Hoxa2 mutant conditional allele generated by Flp- and Cre-mediated recombinationShu-Yue Ren
, CNRS/INSERM/ULP, , Strasbourg, France
Genesis 32:105-8. 2002 - Roles of Hoxa1 and Hoxa2 in patterning the early hindbrain of the mouseJ R Barrow
Howard Hughes Medical Institute, Department of Human Genetics, University of Utah School of Medicine, Salt Lake City, UT 84112, USA
Development 127:933-44. 2000..Two of these genes, Hoxa1 and Hoxa2, have been shown to be required for proper patterning of the early mouse hindbrain and the associated neural crest... - Hoxa2- and rhombomere-dependent development of the mouse facial somatosensory mapFranck Oury
Institut de Genetique et de Biologie Moleculaire et Cellulaire, CNRS INSERM Universite Louis Pasteur, UMR 7104, BP 10142, Communaute Urbaine de Strasbourg, 67404 Illkirch Cedex, France
Science 313:1408-13. 2006..Moreover, early Hoxa2 expression in neuroepithelium prevents the trigeminal nerve from ectopically projecting to the cerebellum, whereas .. - Hoxa1 and Krox-20 synergize to control the development of rhombomere 3F Helmbacher
Unité 368 de l Institut National de la Santé et de la Recherche Médicale, Ecole Normale Superieure, 75230 Paris Cedex 05, France
Development 125:4739-48. 1998..In addition, these data suggest that the control of the development of r3 may not be autonomous but dependent on interactions with Hoxa1-expressing cells... - Segmental expression of Hoxa-2 in the hindbrain is directly regulated by Krox-20S Nonchev
Division of Developmental Neurobiology, MRC National Institute for Medical Research, London, UK
Development 122:543-54. 1996..Therefore, the segmental phenotypes in the Krox-20 mutants are likely to reflect the role of Krox-20 in directly regulating multiple Hox genes... - A Hoxa2 knockin allele that expresses EGFP upon conditional Cre-mediated recombinationMassimo Pasqualetti
, CNRS/INSERM/ULP, , Strasbourg, France
Genesis 32:109-11. 2002 - Role of Hoxa-2 in axon pathfinding and rostral hindbrain patterningA Gavalas
Institut de Genetique et de Biologie Moleculaire et Cellulaire, CNRS INSERM ULP, College de France, CU de Strasbourg
Development 124:3693-702. 1997..These results point to a novel role for Hoxa-2 in the control of r2-r3 motor axon guidance, and also suggest that its absence may lead to homeotic changes in the alar plates of these rhombomeres... - The Hoxa2 enhancer 2 contains a critical Hoxa2 responsive regulatory elementXavier Lampe
Unit of Developmental Genetics, Universite Catholique de Louvain, 73 boîte 82 avenue Mounier, B 1200 Brussels, Belgium
Biochem Biophys Res Commun 316:898-902. 2004..Their identity is specified by Hox genes from paralogous groups 1-4. Hoxa2 is the only Hox gene to be expressed in the second rhombomere and the regulatory cues leading to this region-.. - Hoxa-2 mutant mice exhibit homeotic transformation of skeletal elements derived from cranial neural crestM Gendron-Maguire
Roche Institute of Molecular Biology, Roche Research Center, Nutley, New Jersey 07110
Cell 75:1317-31. 1993..Skeletal elements normally derived from the second arch were absent in the mutants. These data provide direct experimental evidence for the existence of a branchial Hox code... - A homeotic transformation is generated in the rostral branchial region of the head by disruption of Hoxa-2, which acts as a selector geneF M Rijli
Laboratoire de Génétique Moléculaire des Eucaryotes du Centre National de la Recherche Scientifique Unité, Institut de Chimie Biologique Faculté de Médecine
Cell 75:1333-49. 1993..The ground pattern program appears to be modified in the mouse first arch by a Hox-independent process, whereas Hoxa-2 acts as a selector gene in the second arch... 
Murine Hox-1.11 homeobox gene structure and expressionD P Tan
Laboratory of Biochemical Genetics, National Heart Lung and Blood Institute, National Institutes of Health, Bethesda, MD 20892
Proc Natl Acad Sci U S A 89:6280-4. 1992..Hox-1.11 poly(A)+ RNA also is expressed in the VII and VIII cranial ganglia, spinal cord, spinal ganglia, larynx, lungs, vertebrae, sternum, and intestine...- Ectopic Hoxa-1 induces rhombomere transformation in mouse hindbrainM Zhang
Department of Toxicology and Pathology, Roche Research Center, Hoffmann La Roche, Nutley, New Jersey 07110
Development 120:2431-42. 1994..Taken together, these data suggest that ectopic Hoxa-1 expression can reorganize select regions of the developing hindbrain by inducing partial transformations of several rhombomeres into a rhombomere-4-like identity... - Synergy between Hoxa1 and Hoxb1: the relationship between arch patterning and the generation of cranial neural crestA Gavalas
Division of Developmental Neurobiology, MRC National Institute for Medical Research, The Ridgeway, Mill Hill, London NW7 1AA, UK
Development 128:3017-27. 2001..Furthermore, they demonstrate that early patterning of the separate components of the pharyngeal arches can proceed independently of neural crest cell migration... - Mesenchymal patterning by Hoxa2 requires blocking Fgf-dependent activation of Ptx1Nicoletta Bobola
Department of Developmental Biology, Max Planck Institute of Immunobiology, Freiburg, Germany
Development 130:3403-14. 2003..To address this issue, we have analyzed how Hoxa2 specifies segmental identity in the second branchial arch... - Expression of Hoxa2 in cells entering chondrogenesis impairs overall cartilage developmentLaurent Massip
Developmental Genetics Unit, Universite Catholique de Louvain, Brussels, Belgium
Differentiation 75:256-67. 2007..to the silencing of a Hox gene, we generated transgenic mice allowing Cre-mediated conditional misexpression of Hoxa2 and induced this gene in Collagen 2 alpha 1-expressing cells committed to enter chondrogenesis... - SATB2 is a multifunctional determinant of craniofacial patterning and osteoblast differentiationGergana Dobreva
Max Planck Institute of Immunobiology, Department of Cellular and Molecular Immunology, 79108 Freiburg, Germany
Cell 125:971-86. 2006..In addition, SATB2 was found to repress the expression of several Hox genes including Hoxa2, an inhibitor of bone formation and regulator of branchial arch patterning... - Wnt1-Cre-mediated deletion of AP-2alpha causes multiple neural crest-related defectsStephanie Brewer
Department of Molecular, Cellular and Developmental Biology, Yale University, New Haven, CT 06520, USA
Dev Biol 267:135-52. 2004..These results have important implications for the evolution and function of the AP-2 gene family in both the neural crest and the vertebrate embryo... - Hox cofactors in vertebrate developmentCecilia B Moens
Division of Basic Science and HHMI, Fred Hutchinson Cancer Research Center, Seattle, WA 98115, USA
Dev Biol 291:193-206. 2006.... - New regulatory interactions and cellular responses in the isthmic organizer region revealed by altering Gbx2 expressionJames Y H Li
Howard Hughes Medical Institute and Developmental Genetics Program, Skirball Institute of Biomolecular Medicine, New York University School of Medicine, 540 First Avenue, New York, NY 10016, USA
Development 132:1971-81. 2005..Our studies provide new insights into the regulatory interactions that maintain isthmic organizer gene expression and the consequences of altered levels of organizer gene expression on cell survival... - Tbx1 is required for proper neural crest migration and to stabilize spatial patterns during middle and inner ear developmentFilipa Moraes
Instituto Gulbenkian de Ciencia, UT, Rua da Quinta Grande 6, 2780 156 Oeiras, Portugal
Mech Dev 122:199-212. 2005..The inability of the Tbx1(-/-) embryos to keep properly segregated functional domains in the otocyst is likely the cause of the strong inner ear phenotypes observed in these mutants... - Differential expression of Sonic hedgehog along the anterior-posterior axis regulates patterning of pharyngeal pouch endoderm and pharyngeal endoderm-derived organsBillie A Moore-Scott
Institute for Molecular Medicine and Genetics, Medical College of Georgia, Augusta, GA 30912, USA
Dev Biol 278:323-35. 2005..Our data suggest that, as in the posterior gut endoderm, exclusion of Shh expression from developing primordia is required for the proper development of pharyngeal-derived organs... - Tshz1 is required for axial skeleton, soft palate and middle ear development in miceNathalie Coré
Institut de Biologie du Developpement de Marseille Luminy IBDML, UMR6216, CNRS, Universite de la Mediterranee, F 13288 Marseille Cedex 09, France
Dev Biol 308:407-20. 2007..Finally, we demonstrate that Tshz1 is required for the development of the soft palate... 
Ptch1-mediated dosage-dependent action of Shh signaling regulates neural progenitor development at late gestational stagesYayoi Shikata
Brain Science Institute, RIKEN, 2 1 Hirosawa, Wako, Saitama 351 0198, Japan
Dev Biol 349:147-59. 2011..These data indicated that endogenous Ptch1 mediates the broad effects of Shh on the transition from VZ progenitors to IPCs and activation of proliferation of the IPCs in the cortex during late gestational stages...- Matrix metalloproteinase-25 has a functional role in mouse secondary palate development and is a downstream target of TGF-β3Graham D Brown
Laboratory of Molecular Biology, College of Pharmacy and Nutrition, University of Saskatchewan, Saskatoon, Saskatchewan S7N 5C9, Canada
BMC Dev Biol 10:93. 2010..We report on the gene expression profile of MMP-25 in the developing mouse SP and identify its functional role in mouse SP development... - Effects of phenytoin on Satb2 and Hoxa2 gene expressions in mouse embryonic craniofacial tissueXiao Yan Mao
Cleft Lip and Palate Treatment Center, The Second Affiliated Hospital of Shantou University Medical College, Shantou, China
Biochem Cell Biol 88:731-5. 2010..Satb2-deficient mice exhibit cleft palate deformity and an up-regulation of Hoxa2 in the fronto-nasal region... - Mesodermal Tbx1 is required for patterning the proximal mandible in miceVimla S Aggarwal
Department of Molecular Genetics, Albert Einstein College of Medicine, Bronx, NY 10461, USA
Dev Biol 344:669-81. 2010..5. This occurs without significant changes in cell proliferation or apoptosis at the same stage. Our results elucidate a new function for the non-neural crest core mesoderm and specifically, mesodermal Tbx1, in shaping the lower jaw... - Expressing Hoxa2 across the entire endochondral skeleton alters the shape of the skeletal template in a spatially restricted fashionSara Tavella
Dipartimento di Oncologia, Biologia e Genetica, Universita di Genova, Italy
Differentiation 79:194-202. 2010..To clarify these controversial effects, we overexpressed Hoxa2 across the entire developing endochondral skeleton in mouse... - Sprouty genes prevent excessive FGF signalling in multiple cell types throughout development of the cerebellumTian Yu
Department of Craniofacial Development, King s College London, London, UK
Development 138:2957-68. 2011..Taken together, our data demonstrate that FGF signalling levels have to be tightly controlled throughout cerebellar development in order to maintain the normal development of multiple cell types... - Hoxa2 plays a direct role in murine palate developmentTara M Smith
Laboratory of Molecular Biology, College of Pharmacy and Nutrition, University of Saskatchewan, Saskatoon, Saskatchewan, Canada
Dev Dyn 238:2364-73. 2009The cleft palate exhibited by Hoxa2 null murine embryos has been described as being secondary to abnormalities of tongue musculature, and Hoxa2 was presumed to not play a direct role in palate development... - Identification and characterization of VPO1, a new animal heme-containing peroxidaseGuangjie Cheng
Department of Pathology and Laboratory Medicine, Emory University School of Medicine, Atlanta, GA 30322, USA
Free Radic Biol Med 45:1682-94. 2008..5 mM. When co-expressed in cells, VPO1 can use H(2)O(2) produced by NADPH oxidase enzymes. VPO1 is likely to carry out peroxidative reactions previously attributed exclusively to myeloperoxidase in the vascular system... - Rostral hindbrain patterning involves the direct activation of a Krox20 transcriptional enhancer by Hox/Pbx and Meis factorsMichel A Wassef
INSERM, U784, Laboratoire de Génétique Moléculaire du Développement and 46 rue d Ulm, 75230 Paris, France
Development 135:3369-78. 2008..We propose a model for the complex regulation of Krox20, involving a novel mode of initiation, positive and negative controls by Hox proteins, and multiple direct and indirect autoregulatory loops... - Hox paralog group 2 genes control the migration of mouse pontine neurons through slit-robo signalingMarc J Geisen
Institut de Genetique et de Biologie Moleculaire et Cellulaire, CNRS INSERM ULP, UMR 7104, CU de Strasbourg, Illkirch, France
PLoS Biol 6:e142. 2008..Here, we show that Hoxa2 and Hoxb2 are required both intrinsically and extrinsically to maintain normal AP migration of subsets of PN, by .. - Hox and Pbx factors control retinoic acid synthesis during hindbrain segmentationAntonio Vitobello
Friedrich Miescher Institute for Biomedical Research, Basel, Switzerland
Dev Cell 20:469-82. 2011..These findings reveal a feed-forward mechanism linking Hox-Pbx-dependent RA synthesis during early axial patterning with the establishment of spatially restricted Hox-Pbx activity in the developing hindbrain... - Specific regions within the embryonic midbrain and cerebellum require different levels of FGF signaling during developmentM Albert Basson
Department of Anatomy and Program in Developmental Biology, University of California San Francisco, CA 94158, USA
Development 135:889-98. 2008..We suggest a molecular explanation for this phenomenon by providing evidence that FGF signaling functions to inhibit the BMP signaling that promotes roof plate development... - Distinct roles of Hoxa2 and Krox20 in the development of rhythmic neural networks controlling inspiratory depth, respiratory frequency, and jaw openingFabrice Chatonnet
NGI, UPR 2216, Institut de Neurobiologie Alfred Fessard IFR2218, Centre National de Recherche Scientifique, F 91198 Gif sur Yvette Cedex, France
Neural Dev 2:19. 2007..Here, we compare the phenotypes of mice carrying targeted inactivations of Hoxa2, the only Hox gene expressed up to r2, and of Krox20, expressed in r3 and r5... - HBO1 is required for H3K14 acetylation and normal transcriptional activity during embryonic developmentAndrew J Kueh
The Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria, Australia
Mol Cell Biol 31:845-60. 2011..In conclusion, the primary role of HBO1 in development is that of a transcriptional activator, which is indispensable for H3K14 acetylation and for the normal expression of essential genes regulating embryonic development... - Segmental identity can change independently in the hindbrain and rhombencephalic neural crestM Mallo
Max Planck Institute of Immunobiology, Freiburg, Germany
Dev Dyn 210:146-56. 1997..We propose a model for the patterning of the branchial region, according to which the segmental identity in this area is provided mainly by the branchial arches... - Retinoic acid synthesis and hindbrain patterning in the mouse embryoK Niederreither
Institut de Genetique et de Biologie Moleculaire et Cellulaire, CNRS INSERM ULP College de France, CU de Strasbourg
Development 127:75-85. 2000..We conclude that RA produced by the embryo is required to generate posterior cell fates in the developing mouse hindbrain, its absence leading to an abnormal r3 (and, to a lesser extent, r4) identity of the caudal hindbrain cells... - The little (lit) mutation cosegregates with the growth hormone releasing factor receptor on mouse chromosome 6S C Chua
Laboratory of Human Behavior and Metabolism, Rockefeller University, New York, New York 10021
Mamm Genome 4:555-9. 1993..Molecular markers were Neuropeptide Y (Npy), homeobox (Hoxa2), immunoglobulin kappa chain (Igk), wingless-related MMTV integration site (Wnt-2), cystic fibrosis (Cftr), .. - Development of the mammalian ear: coordinate regulation of formation of the tympanic ring and the external acoustic meatusM Mallo
Roche Institute of Molecular Biology, Roche Research Center, Nutley, NJ 07110, USA
Development 122:173-9. 1996.... - Regulation of Hoxa2 in cranial neural crest cells involves members of the AP-2 familyM Maconochie
Laboratory of Developmental Neurobiology, National Institute for Medical Research, The Ridgeway, Mill Hill, London NW7 1AA, UK
Development 126:1483-94. 1999b>Hoxa2 is expressed in cranial neural crest cells that migrate into the second branchial arch and is essential for proper patterning of neural-crest-derived structures in this region... - The expression pattern of the mouse receptor tyrosine kinase gene MDK1 is conserved through evolution and requires Hoxa-2 for rhombomere-specific expression in mouse embryosR Taneja
Institut de Genetique et de Biologie Moleculaire et Cellulaire, CNRS INSERM ULP, College de France, Illkirch, C U de Strasbourg, France
Dev Biol 177:397-412. 1996.... - Orientation of the Hoxa complex and placement of the Hd locus distal to Hoxa2 on mouse chromosome 6J W Innis
Department of Human Genetics, Med Sci. II, Ann Arbor, Michigan 48109-0618, USA
Mamm Genome 7:216-7. 1996 - Sequential roles for Otx2 in visceral endoderm and neuroectoderm for forebrain and midbrain induction and specificationM Rhinn
Institut de Genetique et de Biologie Moleculaire et Cellulaire, CNRS INSERM Universite Louis Pasteur, Strasbourg, France
Development 125:845-56. 1998..Altogether, these results demonstrate that Otx2 is first required in the visceral endoderm for the induction, and subsequently in the neuroectoderm for the specification of forebrain and midbrain territories... - Retinoic acid disturbs mouse middle ear development in a stage-dependent fashionM Mallo
Max Planck Institute of Immunobiology, Freiburg, Germany
Dev Biol 184:175-86. 1997..5 hr of pregnancy. Moreover, interactions between adjacent bones are not required for their proper formation. My results also suggest a Hoxa-2-mediated patterning of the otic capsule in the region where the oval window is located... - Targeted disruption of the mouse homologue of the Drosophila polyhomeotic gene leads to altered anteroposterior patterning and neural crest defectsY Takihara
Department of Medical Genetics, Research Institute for Microbial Diseases, Osaka University, Suita, Japan
Development 124:3673-82. 1997..These results indicate that the rae28 gene is involved in the regulation of Hox gene expression and segment specification during paraxial mesoderm and neural crest development... - Local alterations of Krox-20 and Hox gene expression in the hindbrain suggest lack of rhombomeres 4 and 5 in homozygote null Hoxa-1 (Hox-1.6) mutant embryosP Dolle
Laboratoire de Genetique Moleculaire des Eucaryotes, Centre National de la Recherche Scientifique, L Institut National de la Santé et de la Recherche Médicale, Strasbourg, France
Proc Natl Acad Sci U S A 90:7666-70. 1993..These alterations coincide with the region that is subsequently affected in Hoxa-1 null mutant mice and suggest that the primary defects in this mutation are spatially restricted deletions of some rhombomeric structures... - Temporal and spatial expression of Hoxa-2 during murine palatogenesisA Nazarali
Laboratory of Molecular Biology, College of Pharmacy and Nutrition, University of Saskatchewan, Saskatoon, Canada
Cell Mol Neurobiol 20:269-90. 2000..This along with our new findings of the expression of the Hoxa-2 protein during palatogenesis has shed some light on the putative role of this gene in palate development... - Fgfr1 regulates patterning of the pharyngeal regionNina Trokovic
Institute of Biotechnology, Viikki Biocenter, 00014 University of Helsinki, Finland
Genes Dev 17:141-53. 2003..Our results indicate that Fgfr1 patterns the pharyngeal region to create a permissive environment for neural crest cell migration... - Tooth development is independent of a Hox patterning programmeChela T James
Department of Craniofacial Development, GKT Dental Institute, Kings College London, Guy s Hospital, London Bridge, London, United Kingdom
Dev Dyn 225:332-5. 2002..However, we show that, unlike cartilage and bone, the development of teeth is not affected by alterations in Hoxa2 expression... - Targeted insertion results in a rhombomere 2-specific Hoxa2 knockdown and ectopic activation of Hoxa1 expressionShu Yue Ren
Institut de Genetique et de Biologie Moleculaire et Cellulaire, CNRS INSERM ULP, College de France, Illkirch Cedex, CU de Strasbourg, France
Dev Dyn 225:305-15. 2002..Here, we analysed the effects of the targeted insertion of a PGK-neo cassette in the 3' untranslated region of Hoxa2. Even at this 3' position, the insertion resulted in homozygous mutants that unexpectedly did not survive beyond 3 .. - Hox-1.11 and Hox-4.9 homeobox genesA Nazarali
Laboratory of Biochemical Genetics, National Heart, Lung and Blood Institute, National Institutes of Health, Bethesda, MD 20892
Proc Natl Acad Sci U S A 89:2883-7. 1992..3 and Hox-4.2 genomic DNA revealed some differences in nucleotide sequences and in the deduced homeodomain amino acid sequences compared with the sequences that have been reported... - Mouse Af9 is a controller of embryo patterning, like Mll, whose human homologue fuses with Af9 after chromosomal translocation in leukemiaEmma C Collins
MRC Laboratory of Molecular Biology, Cambridge CB2 2QH, United Kingdom
Mol Cell Biol 22:7313-24. 2002..This is analogous to the role of Mll, the murine homolog of human MLL, to which the Af9 gene fuses in acute myeloid leukemias... - Otx2 and Gbx2 are required for refinement and not induction of mid-hindbrain gene expressionJ Y Li
Howard Hughes Medical Institute and Developmental Genetics Program, Skirball Institute of Biomolecular Medicine, New York University School of Medicine, 540 First Avenue, New York, NY 10016, USA
Development 128:4979-91. 2001..Furthermore, Otx2 and Gbx2 are required to suppress hindbrain and midbrain development, respectively, and thus allow establishment of the normal spatial domains of Fgf8 and other genes... - Roles of retinoic acid receptors and of Hox genes in the patterning of the teeth and of the jaw skeletonM Mark
Institut de Genetique et de Biologie Moleculaire et Cellulaire, CNRS INSERM ULP, Strasbourg, France
Int J Dev Biol 39:111-21. 1995.... - The role of Hoxa-3 in mouse thymus and thyroid developmentN R Manley
Howard Hughes Medical Institute, Department of Human Genetics, University of Utah School of Medicine, Salt Lake City 84112, USA
Development 121:1989-2003. 1995..This variability suggests the presence of a compensating gene or genes, whose utilization is stochastic. A reasonable candidate for providing this compensatory function is the paralogous gene Hoxb-3... - Coordinated expression of Hoxa2, Hoxd1 and Pax6 in the developing diencephalonL V Wolf
Laboratory of Molecular Biology, College of Pharmacy and Nutrition, University of Saskatchewan, Saskatoon, Canada
Neuroreport 12:329-33. 2001Coordinated expression of Hoxa2, Hoxd1 and Pax6 proteins were found to coincide with the three developmental stages of the diencephalon, as described for the mouse brain... - Moz and retinoic acid coordinately regulate H3K9 acetylation, Hox gene expression, and segment identityAnne K Voss
The Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria 3052, Australia
Dev Cell 17:674-86. 2009..In conclusion, our data show that Moz regulates H3K9 acetylation at Hox gene loci and that RA can act independently of Moz to establish specific Hox gene expression boundaries... - The isthmic organizer signal FGF8 is required for cell survival in the prospective midbrain and cerebellumCandace L Chi
Department of Anatomy and Program in Developmental Biology, School of Medicine, University of California at San Francisco, San Francisco, CA 94143 0452, USA
Development 130:2633-44. 2003..Our data show that Fgf8 is part of a complex gene regulatory network that is essential for cell survival in the mes/met... - Six2 functions redundantly immediately downstream of Hoxa2Eva Kutejova
Department of Developmental Biology, Max Planck Institute of Immunobiology, Freiburg, Germany
Development 135:1463-70. 2008..Here, we conclusively demonstrate that Six2 is a direct downstream target of Hoxa2 in vivo and show that the ectopic expression of Six2, observed in the absence of Hoxa2, contributes to the Hoxa2 .. - Early stages of oligodendrocyte development in the embryonic murine spinal cord proceed normally in the absence of Hoxa2Danette J Nicolay
Laboratory of Molecular Biology, College of Pharmacy and Nutrition, University of Saskatchewan, Saskatoon, Saskatchewan
Glia 48:14-26. 2004..One such TF is the homeobox gene Hoxa2, which was recently shown to be expressed by O4(+) pro-oligodendrocytes... - Different levels of Hoxa2 are required for particular developmental processesS Ohnemus
Max Planck Institute of Immunobiology, Stübeweg 51 79108 Freiburg, Germany
Mech Dev 108:135-47. 2001b>Hoxa2 is required for a variety of developmental processes in the branchial arches and in the hindbrain. We have created a Hoxa2 allele that is about 45% as active in transcription as its wild-type counterpart... - A threshold requirement for Gbx2 levels in hindbrain developmentSamuel T Waters
Laboratory of Cancer and Developmental Biology, NCI Frederick, National Institutes of Health, Frederick, MD 21702, USA
Development 133:1991-2000. 2006..As a result of this transformation, the cerebellar midline fails to form. Thus, our studies demonstrate different threshold requirements for the level of Gbx2 gene product in different regions of the hindbrain... - Differential expression of Hoxa-2 protein along the dorsal-ventral axis of the developing and adult mouse spinal cordZ Hao
Laboratory of Molecular Biology, College of Pharmacy and Nutrition, University of Saskatchewan, Saskatoon, Canada
Dev Dyn 216:201-17. 1999..dev dyn 1999;216:201-217... - Lmx1b is essential for Fgf8 and Wnt1 expression in the isthmic organizer during tectum and cerebellum development in miceChao Guo
Institute of Neuroscience and Key Laboratory of Neurobiology, Shanghai Institute for Biological Sciences, Chinese Academy of Sciences, Shanghai 200031, China
Development 134:317-25. 2007.... - SOX3 activity during pharyngeal segmentation is required for craniofacial morphogenesisKarine Rizzoti
Division of Developmental Genetics, MRC National Institute for Medical Research, The Ridgeway, Mill Hill, London NW7 1AA, UK
Development 134:3437-48. 2007..They also give insight into the formation of pharyngeal pouches, of which little is known in vertebrates. Finally, this work introduces two new players in craniofacial development - SOX3 and SOX2... - Hoxa-2 restricts the chondrogenic domain and inhibits bone formation during development of the branchial areaB Kanzler
Max Planck Institute of Immunobiology, Stubeweg 51, Germany
Development 125:2587-97. 1998..The implications of these results on the patterning of the branchial area are discussed... - Non-homeodomain regions of Hox proteins mediate activation versus repression of Six2 via a single enhancer site in vivoAlisha R Yallowitz
Department of Cell and Developmental Biology, University of Michigan, Ann Arbor, MI 48109 2200, USA
Dev Biol 335:156-65. 2009..Six2 is genetically downstream of both the Hox11 paralogous genes in the developing mammalian kidney and Hoxa2 in branchial arch and facial mesenchyme... - Compensatory defects associated with mutations in Hoxa1 restore normal palatogenesis to Hoxa2 mutantsJ R Barrow
Howard Hughes Medical Institute, Department of Human Genetics, University of Utah School of Medicine, Salt Lake City, UT 84112, USA
Development 126:5011-26. 1999..The loss of Hoxa1 or Hoxa2 function affects the development of multiple neural crest-derived structures... - Second branchial arch lineages of the middle ear of wild-type and Hoxa2 mutant miceStephen O'Gorman
Department of Neurosciences, School of Medicine, Case Western Reserve University, Cleveland, OH 44106, USA
Dev Dyn 234:124-31. 2005..In Hoxa2 mutant embryos, middle ear skeletal duplications occurred at sites where first and second arch elements are .. - Molecular phenotype of simian virus 40 large T antigen-induced primitive neuroectodermal tumors in four different lines of transgenic miceK M Fung
Department of Pathology and Laboratory Medicine, Hospital of the University of Pennsylvania, University of Pennsylvania School of Medicine, Philadelphia
Lab Invest 70:114-24. 1994..A third TGM line developed retinoblastomas (a PNET-like tumor of the retina) as well as PNETs in the mesencephalon, while the fourth TGM developed retinoblastomas and adrenal pheochromocytomas...
Research Grants
- GENETIC MECHANISMS OF HINDBRAIN SEGMENTATIONCecilia Moens; Fiscal Year: 2009..Aim 2 addresses the mechanism of plasticity. Finally, in Aim 3, we consider the mechanism by which long-range signals interact to specify the positions of specific hindbrain boundaries. ..
- The Role of Alternative Splicing of Fgf8 in Mouse DevelopmentJames Y H Li; Fiscal Year: 2010..Therefore, our proposed studies should shed light on abnormal regulation of Fgf8 splicing on pathological conditions, including tumor formation in human. ..
- The Role of Alternative Splicing of Fgf8 in Mouse DevelopmentJames Li; Fiscal Year: 2007..Therefore, our proposed studies should shed light on abnormal regulation of Fgf8 splicing on pathological conditions, including tumor formation in human. ..
- GENETIC MECHANISMS OF HINDBRAIN SEGMENTATIONCecilia Moens; Fiscal Year: 2003....
- Role of Gbx2 and Otx2 in the mes-met organizer functionJames Li; Fiscal Year: 2003..abstract_text> ..
- Tilling the Zebrafish Genome: A Reverse Genetic ApproachCecilia Moens; Fiscal Year: 2005..abstract_text> ..
- Tilling the Zebrafish Genome: A Reverse Genetic ApproachLilianna Solnica Krezel; Fiscal Year: 2010..We now propose to use TILLING to identify mutations in 120 genes that are of importance to biomedical research, and to make these mutants available to the zebrafish community as rapidly as possible. ..