Gene Symbol: Hoxa10
Description: homeobox A10
Alias: Hox-1.8, Hoxa-10, homeobox protein Hox-A10, homeo box A10, homeobox protein Hox-1.8
Species: mouse
Products:     Hoxa10

Top Publications

  1. Benson G, Nguyen T, Maas R. The expression pattern of the murine Hoxa-10 gene and the sequence recognition of its homeodomain reveal specific properties of Abdominal B-like genes. Mol Cell Biol. 1995;15:1591-601 pubmed
    ..Thus, in vertebrates, structural similarities, coordinate transcriptional regulation, sites of expression, and binding site preferences all serve to distinguish AbdB from Antp Hox genes. ..
  2. McIntyre D, Rakshit S, Yallowitz A, Loken L, Jeannotte L, Capecchi M, et al. Hox patterning of the vertebrate rib cage. Development. 2007;134:2981-9 pubmed
    ..Thus, the ;Hox code' in somitic mesoderm is the result of the distinct, graded effects of two or more Hox paralogous groups functioning in any anteroposterior location. ..
  3. Shen W, Montgomery J, Rozenfeld S, Moskow J, Lawrence H, Buchberg A, et al. AbdB-like Hox proteins stabilize DNA binding by the Meis1 homeodomain proteins. Mol Cell Biol. 1997;17:6448-58 pubmed
    ..DNA binding complexes formed by Meis1 with Hox proteins dissociate much more slowly than DNA complexes with Meis1 alone, suggesting that Hox proteins stabilize the interactions of Meis1 proteins with their DNA targets. ..
  4. Magnusson M, Brun A, Miyake N, Larsson J, Ehinger M, Bjornsson J, et al. HOXA10 is a critical regulator for hematopoietic stem cells and erythroid/megakaryocyte development. Blood. 2007;109:3687-96 pubmed
    ..In transgenic mice we show that the expression of HOXA10 is tightly regulated by doxycycline...
  5. Hedlund E, Karsten S, Kudo L, Geschwind D, Carpenter E. Identification of a Hoxd10-regulated transcriptional network and combinatorial interactions with Hoxa10 during spinal cord development. J Neurosci Res. 2004;75:307-19 pubmed
    ..and similar magnitude using RT-PCR in Hoxd10 single mutant animals, with additional changes in expression seen in Hoxa10/Hoxd10 double mutant animals...
  6. Wahba G, Hostikka S, Carpenter E. The paralogous Hox genes Hoxa10 and Hoxd10 interact to pattern the mouse hindlimb peripheral nervous system and skeleton. Dev Biol. 2001;231:87-102 pubmed
    ..We have examined the effects of simultaneous inactivation of Hoxa10 and Hoxd10 on mouse hindlimb skeletal and nervous system development...
  7. Wellik D, Capecchi M. Hox10 and Hox11 genes are required to globally pattern the mammalian skeleton. Science. 2003;301:363-7 pubmed
    ..The redundancy among these paralogous family members is so great that this global aspect of Hox patterning is not apparent in mice that are mutant for five of the six paralogous alleles. ..
  8. Haack H, Gruss P. The establishment of murine Hox-1 expression domains during patterning of the limb. Dev Biol. 1993;157:410-22 pubmed
    ..8 and Hox-1.9 were expressed in muscle precursor cells which migrate into the limb. The importance of these findings for the proposed models of limb pattern formation is discussed. ..
  9. Capellini T, Di Giacomo G, Salsi V, Brendolan A, Ferretti E, Srivastava D, et al. Pbx1/Pbx2 requirement for distal limb patterning is mediated by the hierarchical control of Hox gene spatial distribution and Shh expression. Development. 2006;133:2263-73 pubmed

More Information


  1. Wu Y, Wang G, Scott S, Capecchi M. Hoxc10 and Hoxd10 regulate mouse columnar, divisional and motor pool identity of lumbar motoneurons. Development. 2008;135:171-82 pubmed
    ..Together, these results show that Hoxc10 and Hoxd10 play key roles in establishing lumbar motoneuron columnar, divisional and motor pool identity. ..
  2. Scotti M, Kmita M. Recruitment of 5' Hoxa genes in the allantois is essential for proper extra-embryonic function in placental mammals. Development. 2012;139:731-9 pubmed publisher
    ..evidence that this functional novelty is not exclusive to Hoxa13 but is shared with its neighboring Hoxa11 and Hoxa10 genes...
  3. Xi S, Zhu H, Xu H, Schmidtmann A, Geiman T, Muegge K. Lsh controls Hox gene silencing during development. Proc Natl Acad Sci U S A. 2007;104:14366-71 pubmed
    ..Moreover, Lsh can associate with PRC1 components and influence PRC-mediated histone modifications. Thus Lsh is part of a physiological feedback loop that reinforces DNA methylation and silencing of PRC targets. ..
  4. Jorgensen E, Alderman M, Taylor H. Preferential epigenetic programming of estrogen response after in utero xenoestrogen (bisphenol-A) exposure. FASEB J. 2016;30:3194-201 pubmed publisher
    ..Jorgensen, E. M., Alderman, M. H., III, Taylor, H. S. Preferential epigenetic programming of estrogen response after in utero xenoestrogen (bisphenol-A) exposure. ..
  5. Takihara Y, Tomotsune D, Shirai M, Katoh Fukui Y, Nishii K, Motaleb M, et al. Targeted disruption of the mouse homologue of the Drosophila polyhomeotic gene leads to altered anteroposterior patterning and neural crest defects. Development. 1997;124:3673-82 pubmed
    ..These results indicate that the rae28 gene is involved in the regulation of Hox gene expression and segment specification during paraxial mesoderm and neural crest development. ..
  6. Jurberg A, Aires R, Varela Lasheras I, Novoa A, Mallo M. Switching axial progenitors from producing trunk to tail tissues in vertebrate embryos. Dev Cell. 2013;25:451-62 pubmed publisher
    ..Our findings provide a perspective to understand the evolution of the vertebrate body plan...
  7. Podlasek C, Seo R, Clemens J, Ma L, Maas R, Bushman W. Hoxa-10 deficient male mice exhibit abnormal development of the accessory sex organs. Dev Dyn. 1999;214:1-12 pubmed
    ..We interpret these data to indicate that Hoxa-10 is expressed in a region specific manner during late gestation and into the perinatal period and that Hoxa-10 is required for normal accessory sex organ development. ..
  8. Yao M, Lim H, Schust D, Choe S, Farago A, Ding Y, et al. Gene expression profiling reveals progesterone-mediated cell cycle and immunoregulatory roles of Hoxa-10 in the preimplantation uterus. Mol Endocrinol. 2003;17:610-27 pubmed
  9. Reese J, Binart N, Brown N, Ma W, Paria B, Das S, et al. Implantation and decidualization defects in prolactin receptor (PRLR)-deficient mice are mediated by ovarian but not uterine PRLR. Endocrinology. 2000;141:1872-81 pubmed
    ..The function of uterine PRLR remains unclear. However, the eventual loss of pregnancy in P4-treated PRLR-/- mice suggests that uterine PRLR may be essential for the support of late gestation. ..
  10. Branford W, Benson G, Ma L, Maas R, Potter S. Characterization of Hoxa-10/Hoxa-11 transheterozygotes reveals functional redundancy and regulatory interactions. Dev Biol. 2000;224:373-87 pubmed
    ..These results provide a measure of the functional redundancy of Hoxa-10 and Hoxa-11 and a deeper understanding of the phenotypes resulting in the single mutants and help elucidate the regulatory interactions between these two genes. ..
  11. Bei L, Shah C, Wang H, Huang W, Roy R, Eklund E. ?-Catenin activates the HOXA10 and CDX4 genes in myeloid progenitor cells. J Biol Chem. 2012;287:39589-601 pubmed publisher
    b>HoxA10 is a homeodomain transcription factor that is involved in maintenance of the myeloid progenitor population and implicated in myeloid leukemogenesis...
  12. Ford H. Homeobox genes: a link between development, cell cycle, and cancer?. Cell Biol Int. 1998;22:397-400 pubmed
  13. McGrath K, Palis J. Expression of homeobox genes, including an insulin promoting factor, in the murine yolk sac at the time of hematopoietic initiation. Mol Reprod Dev. 1997;48:145-53 pubmed
    ..We hypothesize the early expression of insulin in the YS is required for the expansion of insulin responsive cells including primitive erythroblasts. ..
  14. Das S, Lim H, Paria B, Dey S. Cyclin D3 in the mouse uterus is associated with the decidualization process during early pregnancy. J Mol Endocrinol. 1999;22:91-101 pubmed
    ..Collectively, the results suggest that cyclin D3 could be important for the process of decidualization. ..
  15. Hunt P, Gulisano M, Cook M, Sham M, Faiella A, Wilkinson D, et al. A distinct Hox code for the branchial region of the vertebrate head. Nature. 1991;353:861-4 pubmed
  16. Sheikh B, Downer N, Kueh A, Thomas T, Voss A. Excessive versus physiologically relevant levels of retinoic acid in embryonic stem cell differentiation. Stem Cells. 2014;32:1451-8 pubmed publisher
    ..Our results demonstrate that using RA at physiologically relevant levels to study the activation of Hox genes, more accurately reflects the molecular events during the early phase of Hox gene activation in vivo. ..
  17. Nightingale S, Western P, Hutson J. The migrating gubernaculum grows like a "limb bud". J Pediatr Surg. 2008;43:387-90 pubmed publisher
    ..Our results showed that a member of the fibroblast growth factor (Fgf) family, Fgf10, and Hoxa10 were both expressed in the male gubernaculum at E14.5, and Hoxa10 was also expressed in the E16.5 mice...
  18. Jaiswal M, Mallers T, Larsen B, Kwak Kim J, Chaouat G, Gilman Sachs A, et al. V-ATPase upregulation during early pregnancy: a possible link to establishment of an inflammatory response during preimplantation period of pregnancy. Reproduction. 2012;143:713-25 pubmed publisher
  19. Crawford Parks T, Ravel Chapuis A, Bondy Chorney E, Renaud J, Cote J, Jasmin B. Muscle-specific expression of the RNA-binding protein Staufen1 induces progressive skeletal muscle atrophy via regulation of phosphatase tensin homolog. Hum Mol Genet. 2017;26:1821-1838 pubmed publisher
    ..Collectively, our data demonstrate that Staufen1 is a novel atrophy-associated gene, and highlight its potential as a biomarker and therapeutic target for neuromuscular disorders and conditions. ..
  20. Song H, Lim H, Paria B, Matsumoto H, Swift L, Morrow J, et al. Cytosolic phospholipase A2alpha is crucial [correction of A2alpha deficiency is crucial] for 'on-time' embryo implantation that directs subsequent development. Development. 2002;129:2879-89 pubmed
  21. Bei L, Lu Y, Bellis S, Zhou W, Horvath E, Eklund E. Identification of a HoxA10 activation domain necessary for transcription of the gene encoding beta3 integrin during myeloid differentiation. J Biol Chem. 2007;282:16846-59 pubmed
    ..In these studies, we found that the homeodomain transcription factor HoxA10 interacted with a specific ITGB3 cis element and activated transcription of this gene during myeloid ..
  22. Bobick B, Cobb J. Shox2 regulates progression through chondrogenesis in the mouse proximal limb. J Cell Sci. 2012;125:6071-83 pubmed publisher
    ..Thus, we provide evidence that Shox2 regulates progression through chondrogenesis at two distinct stages--the onset of early differentiation and the transition to maturation and hypertrophy. ..
  23. Eklund E, Goldenberg I, Lu Y, Andrejic J, Kakar R. SHP1 protein-tyrosine phosphatase regulates HoxA10 DNA binding and transcriptional repression activity in undifferentiated myeloid cells. J Biol Chem. 2002;277:36878-88 pubmed
    The homeodomain protein HoxA10 interacts with negative cis elements to repress gene transcription in undifferentiated myeloid cells...
  24. Favier B, Rijli F, Fromental Ramain C, Fraulob V, Chambon P, Dolle P. Functional cooperation between the non-paralogous genes Hoxa-10 and Hoxd-11 in the developing forelimb and axial skeleton. Development. 1996;122:449-60 pubmed
  25. Sadeghi H, Taylor H. HOXA10 regulates endometrial GABAA {pi} receptor expression and membrane translocation. Am J Physiol Endocrinol Metab. 2010;298:E889-93 pubmed publisher
    ..human endometrial adenocarcinoma cell line Ishikawa was treated with progesterone and transfected with pcDNA-HOXA10, HOXA10 siRNA, or respective controls. GABA(A) pi receptor mRNA expression was evaluated by real-time RT-PCR...
  26. Rahman M, Li M, Li P, Wang H, Dey S, Das S. Hoxa-10 deficiency alters region-specific gene expression and perturbs differentiation of natural killer cells during decidualization. Dev Biol. 2006;290:105-17 pubmed
    ..Collectively, the results provide evidence that Hoxa-10 influences a host of genes and cell functions necessary for propagating normal decidual development during the post-implantation period. ..
  27. Choe A, Phun H, Tieu D, Hu Y, Carpenter E. Expression patterns of Hox10 paralogous genes during lumbar spinal cord development. Gene Expr Patterns. 2006;6:730-7 pubmed
    ..The three genes, Hoxa10, Hoxc10, and Hoxd10, are all expressed in the lumbar spinal cord and have distinct expression patterns...
  28. Daikoku T, Tranguch S, Friedman D, Das S, Smith D, Dey S. Proteomic analysis identifies immunophilin FK506 binding protein 4 (FKBP52) as a downstream target of Hoxa10 in the periimplantation mouse uterus. Mol Endocrinol. 2005;19:683-97 pubmed
    ..The transcription factor Hoxa10 is one such critical player in implantation...
  29. Orlovsky K, Kalinkovich A, Rozovskaia T, Shezen E, Itkin T, Alder H, et al. Down-regulation of homeobox genes MEIS1 and HOXA in MLL-rearranged acute leukemia impairs engraftment and reduces proliferation. Proc Natl Acad Sci U S A. 2011;108:7956-61 pubmed publisher
    ..Several most consistently up-regulated targets of MLL fusions, MEIS1, HOXA7, HOXA9, and HOXA10 are functionally related and have been implicated in other types of leukemias...
  30. Shah C, Wang H, Bei L, Platanias L, Eklund E. HoxA10 regulates transcription of the gene encoding transforming growth factor beta2 (TGFbeta2) in myeloid cells. J Biol Chem. 2011;286:3161-76 pubmed publisher
    b>HoxA10 is a homeodomain transcription factor that is maximally expressed in myeloid progenitor cells...
  31. Barna M, Pandolfi P, Niswander L. Gli3 and Plzf cooperate in proximal limb patterning at early stages of limb development. Nature. 2005;436:277-81 pubmed
    ..The initial division of the vertebrate limb into two distinct molecular domains is consistent with fossil evidence indicating that the upper and lower extremities of the limb have different evolutionary origins. ..
  32. Quinn C, Detmar J, Casper R. Pinopodes are present in Lif null and Hoxa10 null mice. Fertil Steril. 2007;88:1021-8 pubmed
    To assess pinopode formation in Lif null and Hoxa10 null mice with infertility secondary to failed implantation. Controlled animal experiment. Animal research and laboratory facility...
  33. Hassan M, Tare R, Lee S, Mandeville M, Weiner B, Montecino M, et al. HOXA10 controls osteoblastogenesis by directly activating bone regulatory and phenotypic genes. Mol Cell Biol. 2007;27:3337-52 pubmed
    b>HOXA10 is necessary for embryonic patterning of skeletal elements, but its function in bone formation beyond this early developmental stage is unknown...
  34. Zhou W, Zhu H, Zhao J, Li H, Wan Y, Cao J, et al. Misexpression of Pknox2 in mouse limb bud mesenchyme perturbs zeugopod development and deltoid crest formation. PLoS ONE. 2013;8:e64237 pubmed publisher
  35. Shen W, Rozenfeld S, Lawrence H, Largman C. The Abd-B-like Hox homeodomain proteins can be subdivided by the ability to form complexes with Pbx1a on a novel DNA target. J Biol Chem. 1997;272:8198-206 pubmed
    ..These data suggest that Abd-B-like Hox proteins bind to a novel TTAC site and can be divided by their cooperative binding to DNA with Pbx1a. ..
  36. Carlson H, Quinn J, Yang Y, Thornburg C, Chang H, Stadler H. LncRNA-HIT Functions as an Epigenetic Regulator of Chondrogenesis through Its Recruitment of p100/CBP Complexes. PLoS Genet. 2015;11:e1005680 pubmed publisher
  37. Doherty L, Kwon H, Taylor H. Regulation of tryptophan 2,3-dioxygenase by HOXA10 enhances embryo viability through serotonin signaling. Am J Physiol Endocrinol Metab. 2011;300:E86-93 pubmed publisher
    ..Here we demonstrate that Hoxa10 regulates endometrial TDO expression and improves embryo viability through increased serotonin production...
  38. Chen J, Zhang J, Lazarenko O, Kang P, Blackburn M, Ronis M, et al. Inhibition of fetal bone development through epigenetic down-regulation of HoxA10 in obese rats fed high-fat diet. FASEB J. 2012;26:1131-41 pubmed publisher
    ..of transcriptional genes for osteogenesis revealed a profound decrease in the homeodomain-containing factor A10 (HoxA10) in FOCCs from fetuses of HFD-induced obese dams...
  39. Wyngaarden L, Delgado Olguin P, Su I, Bruneau B, Hopyan S. Ezh2 regulates anteroposterior axis specification and proximodistal axis elongation in the developing limb. Development. 2011;138:3759-67 pubmed publisher
    ..Ezh2 maintains the late phase of Hox gene expression and cell transposition experiments suggest that it regulates the plasticity with which cells respond to instructive positional cues. ..
  40. Wang H, Bei L, Shah C, Hu L, Eklund E. HoxA10 Terminates Emergency Granulopoiesis by Increasing Expression of Triad1. J Immunol. 2015;194:5375-87 pubmed publisher
    Expression of the E3 ubiquitin ligase Triad1 is greater in mature granulocytes than in myeloid progenitor cells. HoxA10 actives transcription of the gene encoding Triad1 (ARIH2) during myeloid differentiation, but the contribution of ..
  41. Murtha M, Leckman J, Ruddle F. Detection of homeobox genes in development and evolution. Proc Natl Acad Sci U S A. 1991;88:10711-5 pubmed
    ..Cloning of three Antennapedia-related sequences from cnidarians provides evidence of ancient roles for homeobox genes early in metazoan evolution. ..
  42. Yu L, Liu H, Yan M, Yang J, Long F, Muneoka K, et al. Shox2 is required for chondrocyte proliferation and maturation in proximal limb skeleton. Dev Biol. 2007;306:549-59 pubmed
    ..Our results establish a key role for Shox2 in regulating the growth of stylopod by controlling chondrocyte maturation via Runx2 and Runx3. ..
  43. Yue L, Daikoku T, Hou X, Li M, Wang H, Nojima H, et al. Cyclin G1 and cyclin G2 are expressed in the periimplantation mouse uterus in a cell-specific and progesterone-dependent manner: evidence for aberrant regulation with Hoxa-10 deficiency. Endocrinology. 2005;146:2424-33 pubmed
  44. Dorrance A, Liu S, Yuan W, Becknell B, Arnoczky K, Guimond M, et al. Mll partial tandem duplication induces aberrant Hox expression in vivo via specific epigenetic alterations. J Clin Invest. 2006;116:2707-16 pubmed
    ..Mll(PTD/WT) mice overexpress Hoxa7, Hoxa9, and Hoxa10 in spleen, BM, and blood...
  45. Benson G, Lim H, Paria B, Satokata I, Dey S, Maas R. Mechanisms of reduced fertility in Hoxa-10 mutant mice: uterine homeosis and loss of maternal Hoxa-10 expression. Development. 1996;122:2687-96 pubmed
    ..These results show that Hoxa-10 is required during morphogenesis for proper patterning of the reproductive tract and in the adult uterus for peri-implantation events. ..
  46. Madan V, Madan B, Brykczynska U, Zilbermann F, Hogeveen K, Dohner K, et al. Impaired function of primitive hematopoietic cells in mice lacking the Mixed-Lineage-Leukemia homolog MLL5. Blood. 2009;113:1444-54 pubmed publisher
    ..Together, these in vivo findings establish several nonredundant functions for Mll5, including an essential role in regulating proliferation and functional integrity of hematopoietic stem/progenitor cells. ..
  47. Bellessort B, Bachelot A, Heude Ã, Alfama G, Fontaine A, Le Cardinal M, et al. Role of Foxl2 in uterine maturation and function. Hum Mol Genet. 2015;24:3092-103 pubmed publisher
    ..Our data suggest that Foxl2 has a crucial role in PN uterine maturation and could help to understand sub-fertility predisposition in women. ..
  48. Pradeepa M, McKenna F, Taylor G, Bengani H, Grimes G, Wood A, et al. Psip1/p52 regulates posterior Hoxa genes through activation of lncRNA Hottip. PLoS Genet. 2017;13:e1006677 pubmed publisher
    ..and knockout approaches we show that Hottip expression is required for activation of the 5' Hoxa genes (Hoxa13 and Hoxa10/11) and for retaining Mll1 at the 5' end of Hoxa...
  49. Yagi H, Deguchi K, Aono A, Tani Y, Kishimoto T, Komori T. Growth disturbance in fetal liver hematopoiesis of Mll-mutant mice. Blood. 1998;92:108-17 pubmed
    ..These data show that the hematopoietic precursors were greatly reduced in mutant mice, and suggest that Mll functions as a regulator of the growth of hematopoietic precursors. ..
  50. El Mounayri O, Triplett J, Yates C, Herring B. Regulation of smooth muscle-specific gene expression by homeodomain proteins, Hoxa10 and Hoxb8. J Biol Chem. 2005;280:25854-63 pubmed
    ..degenerate reverse transcription-PCR coupled to cDNA library screening we identified two homeodomain proteins, Hoxa10 and Hoxb8, which are expressed in adult mouse smooth muscle tissues...
  51. Daftary G, Taylor H. Pleiotropic effects of Hoxa10 on the functional development of peri-implantation endometrium. Mol Reprod Dev. 2004;67:8-14 pubmed
    b>Hoxa10, a homeodomain transcription factor, is dynamically expressed in adult uterine endometrium where it is necessary for embryo implantation. Endometrial Hoxa10 expression is driven by estrogen and progesterone...
  52. Aires R, Jurberg A, Leal F, Novoa A, Cohn M, Mallo M. Oct4 Is a Key Regulator of Vertebrate Trunk Length Diversity. Dev Cell. 2016;38:262-74 pubmed publisher
  53. Tanaka M, Yu R, Kurokawa D. Anterior migration of lateral plate mesodermal cells during embryogenesis of the pufferfish Takifugu niphobles: insight into the rostral positioning of pelvic fins. J Anat. 2015;227:81-8 pubmed publisher
  54. Innis J, Darling S, Kazen Gillespie K, Post L, Mortlock D, Yang T. Orientation of the Hoxa complex and placement of the Hd locus distal to Hoxa2 on mouse chromosome 6. Mamm Genome. 1996;7:216-7 pubmed
  55. Rousso D, Gaber Z, Wellik D, Morrisey E, Novitch B. Coordinated actions of the forkhead protein Foxp1 and Hox proteins in the columnar organization of spinal motor neurons. Neuron. 2008;59:226-40 pubmed publisher
  56. Karamitros D, Patmanidi A, Kotantaki P, Potocnik A, Bähr Ivacevic T, Benes V, et al. Geminin deletion increases the number of fetal hematopoietic stem cells by affecting the expression of key transcription factors. Development. 2015;142:70-81 pubmed publisher
    ..The chromatin landscape was also modified at the regulatory regions of HOXA10 and GATA1...
  57. Taylor H, Vanden Heuvel G, Igarashi P. A conserved Hox axis in the mouse and human female reproductive system: late establishment and persistent adult expression of the Hoxa cluster genes. Biol Reprod. 1997;57:1338-45 pubmed
    ..The late establishment of a Hox axis and persistent expression of Hox genes in the adult may play an important role in preserving this plasticity...
  58. Delpretti S, Montavon T, Leleu M, Joye E, Tzika A, Milinkovitch M, et al. Multiple enhancers regulate Hoxd genes and the Hotdog LncRNA during cecum budding. Cell Rep. 2013;5:137-50 pubmed publisher
    ..In this context, we discuss the implementation of a common "budding toolkit" between the cecum and the limbs. ..
  59. Vinagre T, Moncaut N, Carapuco M, Novoa A, Bom J, Mallo M. Evidence for a myotomal Hox/Myf cascade governing nonautonomous control of rib specification within global vertebral domains. Dev Cell. 2010;18:655-61 pubmed publisher
    ..Our findings offer a new perspective of how Hox genes produce global patterns in the axial skeleton and support a redundant nonmyogenic role of Myf5 and Myf6 in rib formation. ..
  60. Lindsey S, Zhu C, Lu Y, Eklund E. HoxA10 represses transcription of the gene encoding p67phox in phagocytic cells. J Immunol. 2005;175:5269-79 pubmed
    ..we identified a negative CYBB promoter cis element that is repressed by the homeodomain transcription factor HoxA10. We found that transcriptional repression requires HoxA10-dependent recruitment of histone deacetylase activity to ..
  61. Zhao H, Abraham A, Kim Y, Wang Y, Pestina T, Zhan J, et al. Lentiviral Transfer of γ-Globin with Fusion Gene NUP98-HOXA10HD Expands Hematopoietic Stem Cells and Ameliorates Murine β-Thalassemia. Mol Ther. 2017;25:593-605 pubmed publisher
  62. Woltering J, Noordermeer D, Leleu M, Duboule D. Conservation and divergence of regulatory strategies at Hox Loci and the origin of tetrapod digits. PLoS Biol. 2014;12:e1001773 pubmed publisher
    ..We discuss the possibility to consider regulatory circuitries, rather than expression patterns, as essential parameters to define evolutionary synapomorphies. ..
  63. Nakamura T, Largaespada D, Shaughnessy J, Jenkins N, Copeland N. Cooperative activation of Hoxa and Pbx1-related genes in murine myeloid leukaemias. Nat Genet. 1996;12:149-53 pubmed
    ..These studies provide the first genetic evidence that Pbx1-related genes cooperate with Hox genes in leukaemia formation and identify a number of new murine myeloid leukaemia genes. ..
  64. Gordon J, Hassan M, Koss M, Montecino M, Selleri L, Van Wijnen A, et al. Epigenetic regulation of early osteogenesis and mineralized tissue formation by a HOXA10-PBX1-associated complex. Cells Tissues Organs. 2011;194:146-50 pubmed publisher
    Homeodomain-containing (HOX) factors such as the abdominal class homeodomain protein HOXA10 and the TALE-family protein PBX1 form coregulatory complexes and are potent transcriptional and epigenetic regulators of tissue morphogenesis...
  65. Bei L, Huang W, Wang H, Shah C, Horvath E, Eklund E. HoxA10 activates CDX4 transcription and Cdx4 activates HOXA10 transcription in myeloid cells. J Biol Chem. 2011;286:19047-64 pubmed publisher
    b>HoxA10 is a homeodomain transcription factor that influences a number of developmental processes, including hematopoiesis...
  66. Zacchetti G, Duboule D, Zakany J. Hox gene function in vertebrate gut morphogenesis: the case of the caecum. Development. 2007;134:3967-73 pubmed
    ..These results illuminate components of the genetic cascade necessary for the emergence of this gut segment, crucial for many vertebrates. ..
  67. Bellessort B, Le Cardinal M, Bachelot A, Narboux Nême N, Garagnani P, Pirazzini C, et al. Dlx5 and Dlx6 control uterine adenogenesis during post-natal maturation: possible consequences for endometriosis. Hum Mol Genet. 2016;25:97-108 pubmed publisher
    ..Given their importance for female reproduction, DLX5 and DLX6 must be regarded as interesting targets for future clinical research. ..
  68. Mori M, Kitazume M, Ose R, Kurokawa J, Koga K, Osuga Y, et al. Death effector domain-containing protein (DEDD) is required for uterine decidualization during early pregnancy in mice. J Clin Invest. 2011;121:318-27 pubmed publisher
    ..These results indicate that DEDD is indispensable for the establishment of an adequate uterine environment to support early pregnancy in mice. ..
  69. Goto J, Miyabayashi T, Wakamatsu Y, Takahashi N, Muramatsu M. Organization and expression of mouse Hox3 cluster genes. Mol Gen Genet. 1993;239:41-8 pubmed
    ..6 and Hox3.5 during embryogenesis revealed that the relationship between relative position in the Hox3 cluster and expression domain along antero-posterior axis appears similar to that seen for members of the other Hox clusters. ..
  70. Li D, Zhao S, Yang Z, Duan C, Guo C, Zhang H, et al. Hmgn5 functions downstream of Hoxa10 to regulate uterine decidualization in mice. Cell Cycle. 2016;15:2792-805 pubmed publisher
    ..Further studies found that regulation of cAMP and progesterone on Hmgn5 expression was mediated by Hoxa10. During in vitro decidualization, knockdown of Hmgn5 could abrogate Hoxa10-induced upregulation of Prl8a2 and ..
  71. Quere R, Andradottir S, Brun A, Zubarev R, Karlsson G, Olsson K, et al. High levels of the adhesion molecule CD44 on leukemic cells generate acute myeloid leukemia relapse after withdrawal of the initial transforming event. Leukemia. 2011;25:515-26 pubmed publisher
    ..developed a tetracycline-inducible mouse model of AML, in which the initial transforming event, overexpression of HOXA10, can be eliminated...
  72. Sroga J, Gao F, Ma X, Das S. Overexpression of cyclin D3 improves decidualization defects in Hoxa-10(-/-) mice. Endocrinology. 2012;153:5575-86 pubmed publisher
    ..Collectively, these results demonstrate that cyclin D3 expression influences a host of genes involved in decidualization and can improve decidualization in Hoxa-10(-/-) mice. ..
  73. Yallowitz A, Hrycaj S, Short K, Smyth I, Wellik D. Hox10 genes function in kidney development in the differentiation and integration of the cortical stroma. PLoS ONE. 2011;6:e23410 pubmed publisher
  74. Szumska D, Pieles G, Essalmani R, Bilski M, Mesnard D, Kaur K, et al. VACTERL/caudal regression/Currarino syndrome-like malformations in mice with mutation in the proprotein convertase Pcsk5. Genes Dev. 2008;22:1465-77 pubmed publisher
    ..We propose that Pcsk5, at least in part via GDF11, coordinately regulates caudal Hox paralogs, to control anteroposterior patterning, nephrogenesis, skeletal, and anorectal development. ..
  75. Tranguch S, Cheung Flynn J, Daikoku T, Prapapanich V, Cox M, Xie H, et al. Cochaperone immunophilin FKBP52 is critical to uterine receptivity for embryo implantation. Proc Natl Acad Sci U S A. 2005;102:14326-31 pubmed
    ..Collectively, the present investigation provides evidence for an in vivo role for this cochaperone in regulating tissue-specific hormone action and its critical role in uterine receptivity for implantation. ..
  76. Guerreiro I, Casaca A, Nunes A, Monteiro S, Novoa A, Ferreira R, et al. Regulatory role for a conserved motif adjacent to the homeodomain of Hox10 proteins. Development. 2012;139:2703-10 pubmed publisher
    ..In addition, this motif might also regulate protein activity by alteration of the protein's DNA-binding affinity through changes in the phosphorylation state of two conserved tyrosine residues within the homeodomain. ..
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    ..Our data indicate that craniofacial skeleton formation in higher vertebrates is crucially dependent on epigenetic regulation that keeps in check inhibitors of an osteochondrogenic differentiation program. ..