Gene Symbol: Homer3
Description: homer scaffolding protein 3
Alias: AW146114, homer protein homolog 3, homer homolog 3, homer, neuronal immediate early gene, 3, homer-3
Species: mouse
Products:     Homer3

Top Publications

  1. Tu J, Xiao B, Yuan J, Lanahan A, Leoffert K, Li M, et al. Homer binds a novel proline-rich motif and links group 1 metabotropic glutamate receptors with IP3 receptors. Neuron. 1998;21:717-26 pubmed
    ..These studies identify a novel mechanism in calcium signaling and provide evidence that an IEG, whose expression is driven by synaptic activity, can directly modify a specific synaptic function. ..
  2. Xiao B, Tu J, Petralia R, Yuan J, Doan A, Breder C, et al. Homer regulates the association of group 1 metabotropic glutamate receptors with multivalent complexes of homer-related, synaptic proteins. Neuron. 1998;21:707-16 pubmed
    ..These observations support a model in which the dynamic expression of Homer 1a competes with constitutively expressed CC-Homers to modify synaptic mGluR properties. ..
  3. Ango F, Prezeau L, Muller T, Tu J, Xiao B, Worley P, et al. Agonist-independent activation of metabotropic glutamate receptors by the intracellular protein Homer. Nature. 2001;411:962-5 pubmed
    ..Our results show that these glutamate GPCRs can be directly activated by intracellular proteins as well as by agonists. ..
  4. Ruegsegger C, Stucki D, Steiner S, Angliker N, Radecke J, Keller E, et al. Impaired mTORC1-Dependent Expression of Homer-3 Influences SCA1 Pathophysiology. Neuron. 2016;89:129-46 pubmed publisher
    ..Our work reveals that impaired mTORC1-Homer-3 activity underlies PC susceptibility in SCA1 and presents a promising therapeutic target. ..
  5. Park J, Hu J, Milshteyn A, Zhang P, Moore C, Park S, et al. A prolyl-isomerase mediates dopamine-dependent plasticity and cocaine motor sensitization. Cell. 2013;154:637-50 pubmed publisher
  6. Parisiadou L, Bethani I, Michaki V, Krousti K, Rapti G, Efthimiopoulos S. Homer2 and Homer3 interact with amyloid precursor protein and inhibit Abeta production. Neurobiol Dis. 2008;30:353-64 pubmed publisher
    ..In this study, we provide evidence that Homer2 and Homer3 but not Homer1 proteins interact specifically with APP...
  7. Schreiner D, Müller K, Hofer H. The intracellular domain of the human protocadherin hFat1 interacts with Homer signalling scaffolding proteins. FEBS Lett. 2006;580:5295-300 pubmed
    ..As Homer proteins and Fat1 have been both linked to psychic disorders, their interaction may be of patho-physiological importance. ..
  8. Angrand P, Segura I, Volkel P, Ghidelli S, Terry R, Brajenovic M, et al. Transgenic mouse proteomics identifies new 14-3-3-associated proteins involved in cytoskeletal rearrangements and cell signaling. Mol Cell Proteomics. 2006;5:2211-27 pubmed
    ..of action of 14-3-3zeta in several signaling pathways, such as glutamate receptor signaling via binding to homer homolog 3 (Homer 3) and in cytoskeletal rearrangements and spine morphogenesis by binding and regulating the activity ..
  9. Huang G, Huso D, Bouyain S, Tu J, McCorkell K, May M, et al. NFAT binding and regulation of T cell activation by the cytoplasmic scaffolding Homer proteins. Science. 2008;319:476-81 pubmed publisher
    ..We found that Homer2 and Homer3, members of the Homer family of cytoplasmic scaffolding proteins, are negative regulators of T cell activation...

More Information


  1. Mizutani A, Kuroda Y, Futatsugi A, Furuichi T, Mikoshiba K. Phosphorylation of Homer3 by calcium/calmodulin-dependent kinase II regulates a coupling state of its target molecules in Purkinje cells. J Neurosci. 2008;28:5369-82 pubmed publisher
    ..mice, in which CaMKII activation was reduced, the levels of Homer3 phosphorylation and the soluble form of Homer 3 were markedly lower...
  2. Tao Cheng J, Thein S, Yang Y, Reese T, Gallant P. Homer is concentrated at the postsynaptic density and does not redistribute after acute synaptic stimulation. Neuroscience. 2014;266:80-90 pubmed publisher
    ..In contrast, Shank and calcium/calmodulin-dependent kinase II (CaMKII) accumulate at the PSD upon NMDA treatment, and CaMKII is excluded from the PSD complex under low calcium conditions. ..
  3. Shiraishi Y, Mizutani A, Bito H, Fujisawa K, Narumiya S, Mikoshiba K, et al. Cupidin, an isoform of Homer/Vesl, interacts with the actin cytoskeleton and activated rho family small GTPases and is expressed in developing mouse cerebellar granule cells. J Neurosci. 1999;19:8389-400 pubmed
  4. Shiraishi Y, Mizutani A, Yuasa S, Mikoshiba K, Furuichi T. Differential expression of Homer family proteins in the developing mouse brain. J Comp Neurol. 2004;473:582-99 pubmed
    ..These results demonstrate that Homer family members have distinct regional, cellular, and subcellular distributions in time and space during postnatal brain development. ..
  5. Hu J, Yang L, Kammermeier P, Moore C, BRAKEMAN P, Tu J, et al. Preso1 dynamically regulates group I metabotropic glutamate receptors. Nat Neurosci. 2012;15:836-44 pubmed publisher
    ..Preso1 creates a microdomain for proline-directed kinases with broad substrate specificity to phosphorylate mGluR and to mediate negative regulation. ..
  6. Shin D, Dehoff M, Luo X, Kang S, Tu J, Nayak S, et al. Homer 2 tunes G protein-coupled receptors stimulus intensity by regulating RGS proteins and PLCbeta GAP activities. J Cell Biol. 2003;162:293-303 pubmed
    ..Characterization of Ca2+ signaling in pancreatic acinar cells from Homer2-/- and Homer3-/- mice showed that Homer 3 has no discernible role in Ca2+ signaling in these cells...
  7. Cooper S, Hanson I. A screen for proteins that interact with PAX6: C-terminal mutations disrupt interaction with HOMER3, DNCL1 and TRIM11. BMC Genet. 2005;6:43 pubmed
    ..Three novel PAX6-interacting proteins were identified: the post-synaptic density (PSD) protein HOMER3, the dynein subunit DNCL1, and the tripartite motif protein TRIM11...
  8. Szumlinski K, Dehoff M, Kang S, Frys K, Lominac K, Klugmann M, et al. Homer proteins regulate sensitivity to cocaine. Neuron. 2004;43:401-13 pubmed
    ..These data show that Homer deletion mimics the behavioral and neurochemical phenotype produced by repeated cocaine administration and implicate Homer in regulating addiction to cocaine. ..
  9. Rezvani K, Baalman K, Teng Y, Mee M, Dawson S, Wang H, et al. Proteasomal degradation of the metabotropic glutamate receptor 1? is mediated by Homer-3 via the proteasomal S8 ATPase: Signal transduction and synaptic transmission. J Neurochem. 2012;122:24-37 pubmed publisher
    ..These results suggest that long Homer-3 proteins control the degradation of mGluR1? receptors by shuttling ubiquitinated mGluR-1? receptors to the 26S proteasome via the S8 ATPase which may modulate synaptic transmission. ..