Gene Symbol: Hnrnpl
Description: heterogeneous nuclear ribonucleoprotein L
Alias: C79783, D830027H13Rik, Hnrpl, heterogeneous nuclear ribonucleoprotein L, hnRNP L
Species: mouse
Products:     Hnrnpl

Top Publications

  1. Polydorides A, Okano H, Yang Y, Stefani G, Darnell R. A brain-enriched polypyrimidine tract-binding protein antagonizes the ability of Nova to regulate neuron-specific alternative splicing. Proc Natl Acad Sci U S A. 2000;97:6350-5 pubmed
    ..These results suggest that brPTB is a tissue-restricted RNA binding protein that interacts with and inhibits the ability of Nova to activate exon selection in neurons. ..
  2. Goehe R, Shultz J, Murudkar C, Usanovic S, Lamour N, Massey D, et al. hnRNP L regulates the tumorigenic capacity of lung cancer xenografts in mice via caspase-9 pre-mRNA processing. J Clin Invest. 2010;120:3923-39 pubmed publisher
    ..b>Heterogeneous nuclear ribonucleoprotein L (hnRNP L) interacted with this ESS, and downregulation of hnRNP L expression induced an increase ..
  3. Sewell W, Sparrow D, Smith A, Gonzalez D, Rappaport E, Dunwoodie S, et al. Cyclical expression of the Notch/Wnt regulator Nrarp requires modulation by Dll3 in somitogenesis. Dev Biol. 2009;329:400-9 pubmed publisher
    ..Towards identifying the role of Dll3 in regulating somitogenesis, Nrarp emerges as a potentially important regulator that requires Dll3 but not Lfng for normal function...
  4. Gaudreau M, Grapton D, Helness A, Vadnais C, Fraszczak J, Shooshtarizadeh P, et al. Heterogeneous Nuclear Ribonucleoprotein L is required for the survival and functional integrity of murine hematopoietic stem cells. Sci Rep. 2016;6:27379 pubmed publisher
    ..Here we report that the splice factor and RNA binding protein hnRNP L (heterogeneous nuclear ribonucleoprotein L) is required for hematopoiesis, since its genetic ablation in mice reduces almost all blood cell ..
  5. Ruan X, Li P, Cangelosi A, Yang L, Cao H. A Long Non-coding RNA, lncLGR, Regulates Hepatic Glucokinase Expression and Glycogen Storage during Fasting. Cell Rep. 2016;14:1867-75 pubmed publisher
    ..Mechanistically, lncLGR specifically binds to heterogenous nuclear ribonucleoprotein L (hnRNPL), which is further confirmed to be a transcriptional repressor of GCK in vivo...
  6. Li M, Gou H, Tripathi B, Jiang S, DuBois W, Waybright T, et al. An Apela RNA-Containing Negative Feedback Loop Regulates p53-Mediated Apoptosis in Embryonic Stem Cells. Cell Stem Cell. 2015;16:669-83 pubmed publisher
    ..Instead, Apela functions as a regulatory RNA and interacts with hnRNPL, which prevents the mitochondrial localization and activation of p53...
  7. Giraud M, Jmari N, Du L, Carallis F, Nieland T, Perez Campo F, et al. An RNAi screen for Aire cofactors reveals a role for Hnrnpl in polymerase release and Aire-activated ectopic transcription. Proc Natl Acad Sci U S A. 2014;111:1491-6 pubmed publisher
    ..RNA polymerases (CCNT2 and HEXIM1); mRNA processing and polyadenylation factors were also highlighted (HNRNPL/F, SFRS1, SFRS3, and CLP1)...
  8. Rajan P, Dalgliesh C, Bourgeois C, Heiner M, Emami K, Clark E, et al. Proteomic identification of heterogeneous nuclear ribonucleoprotein L as a novel component of SLM/Sam68 Nuclear Bodies. BMC Cell Biol. 2009;10:82 pubmed publisher
    ..known Sam68-associated proteins (heterogeneous nuclear ribonucleoproteins hnRNP A1, A2/B1 and G), we identified hnRNP L as a novel Sam68-interacting protein partner...
  9. Ferreira J, Carmo Fonseca M. The biogenesis of the coiled body during early mouse development. Development. 1995;121:601-12 pubmed
    ..Our results suggest that the embryonic 'nucleolus-like body' is a structural scaffold that nucleates independently the formation of the coiled body and the assembly of the machinery responsible for ribosome biosynthesis. ..

More Information


  1. Griffith B, Walsh C, Szeszel Fedorowicz W, Timperman A, Salati L. Identification of hnRNPs K, L and A2/B1 as candidate proteins involved in the nutritional regulation of mRNA splicing. Biochim Biophys Acta. 2006;1759:552-61 pubmed
    ..The decrease in binding of these proteins during treatments that increase G6PD expression is consistent with a role for these proteins in the inhibition of G6PD mRNA splicing. ..
  2. Soderberg M, Raffalli Mathieu F, Lang M. Identification of a regulatory cis-element within the 3'-untranslated region of the murine inducible nitric oxide synthase (iNOS) mRNA; interaction with heterogeneous nuclear ribonucleoproteins I and L and role in the iNOS gene expression. Mol Immunol. 2007;44:434-42 pubmed
    The aim of this study was to investigate the role of heterogeneous nuclear ribonucleoprotein I (hnRNPI) and hnRNPL in the regulation of the murine inducible nitric oxide synthase (iNOS) gene during inflammation...
  3. Gaudreau M, Heyd F, Bastien R, Wilhelm B, Moroy T. Alternative splicing controlled by heterogeneous nuclear ribonucleoprotein L regulates development, proliferation, and migration of thymic pre-T cells. J Immunol. 2012;188:5377-88 pubmed publisher
    ..To investigate the role of hnRNP L further, we have generated conditional hnRNP L knockout mice and found that LckCre-mediated deletion of hnRNP L ..
  4. Peddigari S, Li P, Rabe J, Martin S. hnRNPL and nucleolin bind LINE-1 RNA and function as host factors to modulate retrotransposition. Nucleic Acids Res. 2013;41:575-85 pubmed publisher
    ..In contrast, hnRNPL knockdown dramatically increased L1 retrotransposition as well as L1 RNA and ORF1 protein, indicating that this ..
  5. Costain W, Mishra R. PLG regulates hnRNP-L expression in the rat striatum and pre-frontal cortex: identification by ddPCR. Peptides. 2003;24:137-46 pubmed
    ..The identification of altered expression of hnRNP-L following PLG treatment provides insight into the long-term effects of PLG and may provide insight into its molecular mechanism of action. ..
  6. Soderberg M, Raffalli Mathieu F, Lang M. Inflammation modulates the interaction of heterogeneous nuclear ribonucleoprotein (hnRNP) I/polypyrimidine tract binding protein and hnRNP L with the 3'untranslated region of the murine inducible nitric-oxide synthase mRNA. Mol Pharmacol. 2002;62:423-31 pubmed
    ..binds a 43-nt sequence near the 3'end of the 3'UTR and is immunoprecipitated by a monoclonal antibody against hnRNP L. A computer-simulated conformation of the 3'UTR suggests that both binding sites reside in regions easily ..
  7. Cheli Y, Kunicki T. hnRNP L regulates differences in expression of mouse integrin alpha2beta1. Blood. 2006;107:4391-8 pubmed 4 strains carrying Itga2 haplotype 2 results from decreased affinity of heterogeneous ribonucleoprotein L (hnRNP L) for a 6 CA repeat sequence (CA6) within intron 1...
  8. Cazalla D, Newton K, Caceres J. A novel SR-related protein is required for the second step of Pre-mRNA splicing. Mol Cell Biol. 2005;25:2969-80 pubmed
    ..SRrp53 also regulates alternative splicing in a concentration-dependent manner. Taken together, these results suggest that SRrp53 is a novel SR-related protein that has a role both in constitutive and in alternative splicing. ..
  9. Funke B, Zuleger B, Benavente R, Schuster T, Goller M, Stevenin J, et al. The mouse poly(C)-binding protein exists in multiple isoforms and interacts with several RNA-binding proteins. Nucleic Acids Res. 1996;24:3821-8 pubmed
    ..The interaction between mCBP and splicing factor 9G8 was confirmed in vivo. These results suggest a function of mCBP in RNA metabolism. ..