Gene Symbol: Hnrnpc
Description: heterogeneous nuclear ribonucleoprotein C
Alias: AL022939, D14Wsu171e, Hnrpc, Hnrpc1, Hnrpc2, hnRNPC1, hnRNPC2, hnrnp-C, heterogeneous nuclear ribonucleoproteins C1/C2, heterogeneous nuclear ribonucleoprotein C1, heterogeneous nuclear ribonucleoprotein C2, heterogeneous ribonucleoprotein C1/C2, hnRNP C1 / hnRNP C2, hnRNP C1/C2, hnRNP C2, snoRNA MBI-122
Species: mouse
Products:     Hnrnpc

Top Publications

  1. Hamada T, Miyakawa K, Kushige H, Shibata S, Kurachi S. Age-related expression analysis of mouse liver nuclear protein binding to 3'-untranslated region of Period2 gene. J Physiol Sci. 2015;65:349-57 pubmed publisher
    ..Here, we describe other members of this protein family, hnRNP C and hnRNP H, which bind to the 3'-UTR of the mouse circadian clock gene Period 2 (mPer2)...
  2. von Melchner H, DeGregori J, Rayburn H, Reddy S, Friedel C, Ruley H. Selective disruption of genes expressed in totipotent embryonal stem cells. Genes Dev. 1992;6:919-27 pubmed
  3. Raffalli Mathieu F, Geneste O, Lang M. Characterization of two nuclear proteins that interact with cytochrome P-450 1A2 mRNA. Regulation of RNA binding and possible role in the expression of the Cyp1a2 gene. Eur J Biochem. 1997;245:17-24 pubmed
  4. Williamson D, Banik Maiti S, DeGregori J, Ruley H. hnRNP C is required for postimplantation mouse development but Is dispensable for cell viability. Mol Cell Biol. 2000;20:4094-105 pubmed
    ..These results indicate that the C1 and C2 hnRNPs are not required for any essential step in mRNA biogenesis; however, the proteins may influence the rate and/or fidelity of one or more steps. ..
  5. Abramova N, Charniga C, Goderie S, Temple S. Stage-specific changes in gene expression in acutely isolated mouse CNS progenitor cells. Dev Biol. 2005;283:269-81 pubmed
    ..These data indicate that progenitor cells change during development and that adult and embryonic neural progenitor cells are intrinsically different. ..
  6. Rivera D, Fedele E, Marinari U, Pronzato M, Ricciarelli R. Evaluating the role of hnRNP-C and FMRP in the cAMP-induced APP metabolism. Biofactors. 2015;41:121-6 pubmed publisher
    ..Using RNA immunoprecipitation and RNA-silencing approaches, we found that neither hnRNP-C nor FMRP is required for cAMP to stimulate APP and Aβ production. ..
  7. Borreca A, Gironi K, Amadoro G, Ammassari Teule M. Opposite Dysregulation of Fragile-X Mental Retardation Protein and Heteronuclear Ribonucleoprotein C Protein Associates with Enhanced APP Translation in Alzheimer Disease. Mol Neurobiol. 2016;53:3227-3234 pubmed publisher
    ..Fragile-X Mental Retardation Protein (FMRP) and heteronuclear Ribonucleoprotein C (hnRNP C), exert an opposite control on APP translation, we have analyzed whether expression and translation of these two ..
  8. Ferreira J, Carmo Fonseca M. The biogenesis of the coiled body during early mouse development. Development. 1995;121:601-12 pubmed
    ..Our results suggest that the embryonic 'nucleolus-like body' is a structural scaffold that nucleates independently the formation of the coiled body and the assembly of the machinery responsible for ribosome biosynthesis. ..
  9. Misawa K, Nosaka T, Morita S, Kaneko A, Nakahata T, Asano S, et al. A method to identify cDNAs based on localization of green fluorescent protein fusion products. Proc Natl Acad Sci U S A. 2000;97:3062-6 pubmed
    ..Using FL-REX, we have identified 25 cDNAs, most of which showed reasonable subcellular localization as GFP-fusion proteins, indicating that FL-REX is useful for identification of proteins that show specific intracellular localization. ..

More Information


  1. Attia M, Forster A, Rachez C, Freemont P, Avner P, Rogner U. Interaction between nucleosome assembly protein 1-like family members. J Mol Biol. 2011;407:647-60 pubmed publisher
  2. Jia R, Li X, Yu C, Fan M, Guo J. The splicing factor hnRNP C regulates expression of co-stimulatory molecules CD80 and CD40 in dendritic cells. Immunol Lett. 2013;153:27-32 pubmed publisher
    ..of splicing factors in the maturation of dendritic cells, we analyzed the expression of the splicing factors hnRNP C and hnRNP A1 during maturation of the mouse dendritic cell line DC2...
  3. Strotmann J, Hoppe R, Conzelmann S, Feinstein P, Mombaerts P, Breer H. Small subfamily of olfactory receptor genes: structural features, expression pattern and genomic organization. Gene. 1999;236:281-91 pubmed
    ..These data suggest the involvement of locus-dependent mechanisms for the spatial control of OR gene expression. ..
  4. Kattapuram T, Yang S, Maki J, Stone J. Protein kinase CK1alpha regulates mRNA binding by heterogeneous nuclear ribonucleoprotein C in response to physiologic levels of hydrogen peroxide. J Biol Chem. 2005;280:15340-7 pubmed
    ..In contrast, hnRNP-C1 that was also modified at the CK1alpha phosphorylation sites exhibited a 14-500-fold decrease in binding affinity, demonstrating that CK1alpha-mediated phosphorylation modulates the mRNA binding ability of hnRNP-C. ..
  5. Spahn A, Blondeau N, Heurteaux C, Dehghani F, Rami A. Concomitant transitory up-regulation of X-linked inhibitor of apoptosis protein (XIAP) and the heterogeneous nuclear ribonucleoprotein C1-C2 in surviving cells during neuronal apoptosis. Neurochem Res. 2008;33:1859-68 pubmed publisher an internal ribosome entry site (IRES) element, which requires the interaction of the heterogeneous nuclear ribonucleoprotein C1-C2 (hnRNP-C1/C2)...