Gene Symbol: Hnrnpab
Description: heterogeneous nuclear ribonucleoprotein A/B
Alias: 3010025C11Rik, CBF-A, Cgbfa, Hnrpab, heterogeneous nuclear ribonucleoprotein A/B, CArG-binding factor-A, S1 protein D2, hnRNP A/B
Species: mouse
Products:     Hnrnpab

Top Publications

  1. Tucker P, Liu C, Mushinski J, Blattner F. Mouse immunoglobulin D: messenger RNA and genomic DNA sequences. Science. 1980;209:1353-60 pubmed
    ..The tumor's expression of the delta gene may be aberrant, but the simplest interpretation would be that this tumor expresses one of the several biologically significant forms of the delta chain. ..
  2. Dean J, Sully G, Wait R, Rawlinson L, Clark A, Saklatvala J. Identification of a novel AU-rich-element-binding protein which is related to AUF1. Biochem J. 2002;366:709-19 pubmed
    ..The similarity between CBF-A and AUF1 suggests that CBF-A could be re-named AUF2. ..
  3. Raju C, Fukuda N, Lopez Iglesias C, Goritz C, Visa N, Percipalle P. In neurons, activity-dependent association of dendritically transported mRNA transcripts with the transacting factor CBF-A is mediated by A2RE/RTS elements. Mol Biol Cell. 2011;22:1864-77 pubmed publisher
    ..We propose that CBF-A cotranscriptionally binds RTSs in Arc, BDNF, and CaMKII? mRNAs and follows the transcripts from genes to dendrites, promoting activity-dependent nuclear sorting of transport-competent mRNAs. ..
  4. Sinnamon J, Waddell C, Nik S, Chen E, Czaplinski K. Hnrpab regulates neural development and neuron cell survival after glutamate stimulation. RNA. 2012;18:704-19 pubmed publisher
    ..The RNA-binding protein Hnrpab is highly expressed in developing nervous tissue and in neurogenic regions of the adult brain, but its role in ..
  5. Kamada S, Miwa T. A protein binding to CArG box motifs and to single-stranded DNA functions as a transcriptional repressor. Gene. 1992;119:229-36 pubmed
    ..The fusion protein could bind to ssDNA, whereas CBF in C2 cell nuclear extracts could not. From these results, CBF-A is a novel CArG box-, ssDNA- and RNA-binding protein, as well as a repressive transcriptional factor. ..
  6. Inoue A, Omori A, Ichinose S, Takahashi K, Kinoshita Y, Mita S. S1 proteins C2 and D2 are novel hnRNPs similar to the transcriptional repressor, CArG box motif-binding factor A. Eur J Biochem. 2001;268:3654-63 pubmed
    ..Thus, the present results demonstrate that S1 proteins C2 and D2 are novel hnRNP proteins, and suggest that the proteins C2 and D2 act in both transcriptional and post-transcriptional processes in gene expression. ..
  7. Gao C, Guo H, Wei J, Mi Z, Wai P, Kuo P. S-nitrosylation of heterogeneous nuclear ribonucleoprotein A/B regulates osteopontin transcription in endotoxin-stimulated murine macrophages. J Biol Chem. 2004;279:11236-43 pubmed
    ..Our findings suggest that LPS induced S-nitrosylation of hnRNP inhibits its activity as a constitutive repressor of the OPN promoter and results in enhanced OPN expression. ..
  8. Levros L, Do Carmo S, Edouard E, Legault P, Charfi C, Rassart E. Characterization of nuclear factors modulating the apolipoprotein D promoter during growth arrest: implication of PARP-1, APEX-1 and ERK1/2 catalytic activities. Biochim Biophys Acta. 2010;1803:1062-71 pubmed publisher
    ..Altogether, these findings demonstrate the importance of Parp-1, APEX-1 and ERK1/2 catalytic activities in the growth arrest-induced apoD gene expression. ..
  9. Taga Y, Miyoshi M, Okajima T, Matsuda T, Nadano D. Identification of heterogeneous nuclear ribonucleoprotein A/B as a cytoplasmic mRNA-binding protein in early involution of the mouse mammary gland. Cell Biochem Funct. 2010;28:321-8 pubmed publisher
    ..This identified heterogeneous nuclear ribonucleoprotein A/B (Hnrpab), along with three other heterogeneous nuclear ribonucleoproteins...

More Information


  1. Fukuda N, Fukuda T, Sinnamon J, Hernández Hernández A, Izadi M, Raju C, et al. The transacting factor CBF-A/Hnrnpab binds to the A2RE/RTS element of protamine 2 mRNA and contributes to its translational regulation during mouse spermatogenesis. PLoS Genet. 2013;9:e1003858 pubmed publisher
    ..The transacting factor CBF-A, also termed Hnrnpab, contributes to temporal regulation of Prm2 translation...
  2. Fowles L, Bennetts J, Berkman J, Williams E, Koopman P, Teasdale R, et al. Genomic screen for genes involved in mammalian craniofacial development. Genesis. 2003;35:73-87 pubmed
  3. Venkov C, Link A, Jennings J, Plieth D, Inoue T, Nagai K, et al. A proximal activator of transcription in epithelial-mesenchymal transition. J Clin Invest. 2007;117:482-91 pubmed
    ..We believe formation of the CBF-A/KAP-1/FTS-1 complex is sufficient for the induction of FSP1 and a novel proximal activator of EMT. ..
  4. Chen C, Wu M, Lee Y, Layne M, Yet S. Intronic CArG box regulates cysteine-rich protein 2 expression in the adult but not in developing vasculature. Arterioscler Thromb Vasc Biol. 2010;30:835-42 pubmed publisher
    ..Our results suggest that distinct mechanisms regulate CRP2 expression in VSMC that are controlled by separate embryonic and adult regulatory modules. ..
  5. Carpenter S, Aiello D, Atianand M, Ricci E, Gandhi P, Hall L, et al. A long noncoding RNA mediates both activation and repression of immune response genes. Science. 2013;341:789-92 pubmed publisher
    ..Collectively, these studies unveil a central role of lincRNA-Cox2 as a broad-acting regulatory component of the circuit that controls the inflammatory response. ..
  6. Rousseau S, Morrice N, Peggie M, Campbell D, Gaestel M, Cohen P. Inhibition of SAPK2a/p38 prevents hnRNP A0 phosphorylation by MAPKAP-K2 and its interaction with cytokine mRNAs. EMBO J. 2002;21:6505-14 pubmed
    ..Our data suggest that LPS-induced binding of hnRNP A0 to AREs may contribute to the post-transcriptional regulation of specific mRNAs. ..