Gene Symbol: Hnrnpa1
Description: heterogeneous nuclear ribonucleoprotein A1
Alias: HDP-1, Hdp, Hnrpa1, hnRNP A1, hnrnp-A1, heterogeneous nuclear ribonucleoprotein A1, helix-destabilizing protein, hnRNP core protein A1, single-strand-binding protein, topoisomerase-inhibitor suppressed
Species: mouse
Products:     Hnrnpa1

Top Publications

  1. Yang X, Bani M, Lu S, Rowan S, Ben David Y, Chabot B. The A1 and A1B proteins of heterogeneous nuclear ribonucleoparticles modulate 5' splice site selection in vivo. Proc Natl Acad Sci U S A. 1994;91:6924-8 pubmed
    ..We used a mouse erythroleukemia (MEL) cell line (CB3C7) deficient in the expression of hnRNP A1 to test whether variations in hnRNP A1 and AlB protein levels affected alternative splicing in vivo...
  2. Pedrotti S, Busà R, Compagnucci C, Sette C. The RNA recognition motif protein RBM11 is a novel tissue-specific splicing regulator. Nucleic Acids Res. 2012;40:1021-32 pubmed publisher
    ..Thus, our findings identify RBM11 as a novel tissue-specific splicing factor with potential implication in the regulation of alternative splicing during neuron and germ cell differentiation. ..
  3. Moshiri A, Puppo M, Rossi M, Gherzi R, Briata P. Resveratrol limits epithelial to mesenchymal transition through modulation of KHSRP/hnRNPA1-dependent alternative splicing in mammary gland cells. Biochim Biophys Acta Gene Regul Mech. 2017;1860:291-298 pubmed publisher
    ..factors to the respective epithelial forms and increases the expression of the RNA-binding proteins KHSRP and hnRNPA1. From a mechanistic point of view, we show that the combined silencing of KHSRP and hnRNPA1 prevents the RESV-..
  4. Onishi Y, Kizaki H. Molecular cloning of the genes suppressed in RVC lymphoma cells by topoisomerase inhibitors. Biochem Biophys Res Commun. 1996;228:7-13 pubmed
    ..7 kb and which encoded a protein of 320 amino acids, was identical to hnRNP A1. The other was a novel gene of about 2.2 kb encoding a protein of 469 amino acids...
  5. Irwin S, Vandelft M, Pinchev D, Howell J, Graczyk J, Orr H, et al. RNA association and nucleocytoplasmic shuttling by ataxin-1. J Cell Sci. 2005;118:233-42 pubmed
    ..These results suggest that the normal role of ataxin-1 may be in RNA processing, perhaps nuclear RNA export. Thus, nuclear retention of mutant ataxin-1 may be an important toxic gain of function in SCA1 disease. ..
  6. Gompers A, Su Feher L, Ellegood J, Copping N, Riyadh M, Stradleigh T, et al. Germline Chd8 haploinsufficiency alters brain development in mouse. Nat Neurosci. 2017;20:1062-1073 pubmed publisher
    ..This integrative analysis offers an initial picture of the consequences of Chd8 haploinsufficiency for brain development. ..
  7. Bevilacqua E, Wang X, Majumder M, Gaccioli F, Yuan C, Wang C, et al. eIF2alpha phosphorylation tips the balance to apoptosis during osmotic stress. J Biol Chem. 2010;285:17098-111 pubmed publisher
    ..between eIF2alpha phosphorylation and the subcellular distribution of the RNA-binding protein heterogeneous nuclear ribonucleoprotein A1 (hnRNP A1)...
  8. Clower C, Chatterjee D, Wang Z, Cantley L, Vander Heiden M, Krainer A. The alternative splicing repressors hnRNP A1/A2 and PTB influence pyruvate kinase isoform expression and cell metabolism. Proc Natl Acad Sci U S A. 2010;107:1894-9 pubmed publisher
    ..mRNA is expressed in cell lines derived from brain tumors--and demonstrate that the related splicing repressors hnRNP A1 and A2, as well as the polypyrimidine-tract-binding protein PTB, contribute to this control...
  9. Wilhelm D, Huang E, Svingen T, Stanfield S, Dinnis D, Koopman P. Comparative proteomic analysis to study molecular events during gonad development in mice. Genesis. 2006;44:168-76 pubmed
    ..Three proteins, hnRPA1, TRA1, and HSC71, were found to be expressed in a male-specific manner and this expression was confirmed by real-..

More Information


  1. Zearfoss N, Johnson E, Ryder S. hnRNP A1 and secondary structure coordinate alternative splicing of Mag. RNA. 2013;19:948-57 pubmed publisher
    ..In a previous study, we showed that heteronuclear ribonucleoprotein A1 (hnRNP A1) contributes to Mag exon 12 skipping...
  2. Papadodima O, Chatziioannou A, Patrinou Georgoula M, Kolisis F, Pletsa V, Guialis A. HuR-regulated mRNAs associated with nuclear hnRNP A1-RNP complexes. Int J Mol Sci. 2013;14:20256-81 pubmed publisher
    ..We have been interested in the concerted action of the two RNA-binding proteins hnRNP A1 and HuR, both stable components of immunoselected hnRNP complexes and having a major nuclear localization...
  3. Shi S, Huang P, Li H, Lai M. Regulation of mouse hepatitis virus RNA synthesis by heterogeneous nuclear ribonucleoprotein A1. Adv Exp Med Biol. 2001;494:429-36 pubmed
  4. Tilloy Ellul A, Raffalli Mathieu F, Lang M. Analysis of RNA-protein interactions of mouse liver cytochrome P4502A5 mRNA. Biochem J. 1999;339 ( Pt 3):695-703 pubmed
    ..competition experiments with an oligoribonucleotide corresponding to a known high-affinity binding site of hnRNP A1, and immunoprecipitation of the UV cross-linked 37/39 kDa complex showed that the protein binding to the CYP2A5 ..
  5. Fang J, Bolanos L, Choi K, Liu X, Christie S, Akunuru S, et al. Ubiquitination of hnRNPA1 by TRAF6 links chronic innate immune signaling with myelodysplasia. Nat Immunol. 2017;18:236-245 pubmed publisher
    ..Using a global Ub screen, we identified hnRNPA1, an RNA-binding protein and auxiliary splicing factor, as a substrate of TRAF6...
  6. Rousseau S, Morrice N, Peggie M, Campbell D, Gaestel M, Cohen P. Inhibition of SAPK2a/p38 prevents hnRNP A0 phosphorylation by MAPKAP-K2 and its interaction with cytokine mRNAs. EMBO J. 2002;21:6505-14 pubmed
    ..Our data suggest that LPS-induced binding of hnRNP A0 to AREs may contribute to the post-transcriptional regulation of specific mRNAs. ..
  7. Mizutani T, Ishizaka A, Suzuki Y, Iba H. 7SK small nuclear ribonucleoprotein complex is recruited to the HIV-1 promoter via short viral transcripts. FEBS Lett. 2014;588:1630-6 pubmed publisher recruited to the HIV-1 promoter via newly-synthesized HIV-1 nascent transcripts (short transcripts) in an hnRNP A1-dependent manner and negatively regulates viral transcript elongation...
  8. Zearfoss N, Clingman C, Farley B, McCoig L, Ryder S. Quaking regulates Hnrnpa1 expression through its 3' UTR in oligodendrocyte precursor cells. PLoS Genet. 2011;7:e1001269 pubmed publisher
    ..Analysis of exon expression across the transcriptome reveals that QK and hnRNP A1 regulate an overlapping subset of transcripts...
  9. Glisovic T, Ben David Y, Lang M, Raffalli Mathieu F. Interplay between hnRNP A1 and a cis-acting element in the 3' UTR of CYP2A5 mRNA is central for high expression of the gene. FEBS Lett. 2003;535:147-52 pubmed
    ..either the full length 3' UTR, or the 3' UTR lacking a previously described 71 nucleotide (nt) region (the hnRNP A1 primary binding site), were transiently expressed in cells expressing or lacking hnRNP A1...
  10. Zerbe L, Pino I, Pio R, Cosper P, Dwyer Nield L, Meyer A, et al. Relative amounts of antagonistic splicing factors, hnRNP A1 and ASF/SF2, change during neoplastic lung growth: implications for pre-mRNA processing. Mol Carcinog. 2004;41:187-96 pubmed
    ..Both hnRNP A1 and ASF/SF2 contents rose in adenomas and during injury-induced hyperplasia compared to control lungs, as ..
  11. López Manríquez E, Vashist S, Ureña L, Goodfellow I, Chavez P, Mora Heredia J, et al. Norovirus genome circularization and efficient replication are facilitated by binding of PCBP2 and hnRNP A1. J Virol. 2013;87:11371-87 pubmed publisher
    ..Both PCBP2 and hnRNP A1 recombinant proteins stabilized the 5'-3' interactions and formed ribonucleoprotein complexes with the 5' and 3' ..
  12. Ando K, Fujiya M, Konishi H, Ueno N, Inaba Y, Moriichi K, et al. Heterogeneous Nuclear Ribonucleoprotein A1 Improves the Intestinal Injury by Regulating Apoptosis Through Trefoil Factor 2 in Mice with Anti-CD3-induced Enteritis. Inflamm Bowel Dis. 2015;21:1541-52 pubmed publisher
    The role of hnRNP A1 in the onset of intestinal inflammation remains unclear. This study investigated the function of hnRNP A1 in mice enteritis models...
  13. Jo O, Martin J, Bernath A, Masri J, Lichtenstein A, Gera J. Heterogeneous nuclear ribonucleoprotein A1 regulates cyclin D1 and c-myc internal ribosome entry site function through Akt signaling. J Biol Chem. 2008;283:23274-87 pubmed publisher
    ..Here we identify hnRNP A1 as an IRES trans-acting factor that regulates cyclin D1 and c-myc IRES activity, depending on the Akt status of ..
  14. Martin J, Masri J, Cloninger C, Holmes B, Artinian N, Funk A, et al. Phosphomimetic substitution of heterogeneous nuclear ribonucleoprotein A1 at serine 199 abolishes AKT-dependent internal ribosome entry site-transacting factor (ITAF) function via effects on strand annealing and results in mammalian target of rapamyc. J Biol Chem. 2011;286:16402-13 pubmed publisher
    ..AKT phosphorylation of hnRNP A1 at serine 199 has been demonstrated to inhibit IRES-mediated translation initiation...
  15. Pelisch F, Khauv D, Risso G, Stallings Mann M, Blaustein M, Quadrana L, et al. Involvement of hnRNP A1 in the matrix metalloprotease-3-dependent regulation of Rac1 pre-mRNA splicing. J Cell Biochem. 2012;113:2319-29 pubmed publisher
    ..We find that hnRNP A1 binds to Rac1 exon 3b in mouse mammary epithelial cells, repressing its inclusion into mature mRNA...
  16. Zhang L, Chen Q, An W, Yang F, Maguire E, Chen D, et al. Novel Pathological Role of hnRNPA1 (Heterogeneous Nuclear Ribonucleoprotein A1) in Vascular Smooth Muscle Cell Function and Neointima Hyperplasia. Arterioscler Thromb Vasc Biol. 2017;37:2182-2194 pubmed publisher
    hnRNPA1 (heterogeneous nuclear ribonucleoprotein A1) plays a variety of roles in gene expression...
  17. Gabanella F, Carissimi C, Usiello A, Pellizzoni L. The activity of the spinal muscular atrophy protein is regulated during development and cellular differentiation. Hum Mol Genet. 2005;14:3629-42 pubmed
    ..These results demonstrate that the SMN complex activity in snRNP assembly is regulated and point to a differential requirement for SMN function during development and cellular differentiation. ..
  18. Ferreira J, Carmo Fonseca M. The biogenesis of the coiled body during early mouse development. Development. 1995;121:601-12 pubmed
    ..Our results suggest that the embryonic 'nucleolus-like body' is a structural scaffold that nucleates independently the formation of the coiled body and the assembly of the machinery responsible for ribosome biosynthesis. ..
  19. Varmuza S, Tate P. Isolation of epiblast-specific cDNA clones by differential hybridization with polymerase chain reaction-amplified probes derived from single embryos. Mol Reprod Dev. 1992;32:339-48 pubmed
    ..This approach may prove useful for identifying genes that play a role during development. ..
  20. Naito Y, Yamada T, Ui Tei K, Morishita S, Saigo K. siDirect: highly effective, target-specific siRNA design software for mammalian RNA interference. Nucleic Acids Res. 2004;32:W124-9 pubmed
    ..The website accepts an arbitrary sequence as input and quickly returns siRNA candidates, providing a wide scope of applications in mammalian RNAi, including systematic functional genomics and therapeutic gene silencing. ..
  21. Hou V, Lersch R, Gee S, Ponthier J, Lo A, Wu M, et al. Decrease in hnRNP A/B expression during erythropoiesis mediates a pre-mRNA splicing switch. EMBO J. 2002;21:6195-204 pubmed
    ..These findings demonstrate that natural developmental changes in hnRNP A/B proteins can effect physiologically important switches in pre-mRNA splicing. ..
  22. Zhang X, Lyle C, Wang Y, Zeng L. Role of hnRNP A1 in coronavirus RNA synthesis. Adv Exp Med Biol. 2001;494:437-46 pubmed
  23. Frankfort B, Gelman I. Identification of novel cellular genes transcriptionally suppressed by v-src. Biochem Biophys Res Commun. 1995;206:916-26 pubmed
    ..The remaining 6 cDNAs are indentical or highly similar to rat helix-destabilizing protein gene (hnRNP A1), mouse CTLA-2 alpha cysteine protease, rat cytochrome c oxidase (COX) VIc subunit, mouse Type I collagen, human ..
  24. Gao G, Dhar S, Bedford M. PRMT5 regulates IRES-dependent translation via methylation of hnRNP A1. Nucleic Acids Res. 2017;45:4359-4369 pubmed publisher
    ..The heterogeneous nuclear ribonucleoprotein, hnRNP A1, is an IRES transacting factor (ITAF) that regulates the IRES-dependent translation of Cyclin D1 and c-Myc...
  25. Ben David Y, Bani M, Chabot B, De Koven A, Bernstein A. Retroviral insertions downstream of the heterogeneous nuclear ribonucleoprotein A1 gene in erythroleukemia cells: evidence that A1 is not essential for cell growth. Mol Cell Biol. 1992;12:4449-55 pubmed a transcript originating from genomic DNA adjacent to Fli-2 is identical to that of the human heterogeneous nuclear ribonucleoprotein A1 gene, a member of the gene family of RNA-binding proteins involved in RNA splicing...
  26. Cazalla D, Newton K, Caceres J. A novel SR-related protein is required for the second step of Pre-mRNA splicing. Mol Cell Biol. 2005;25:2969-80 pubmed
    ..SRrp53 also regulates alternative splicing in a concentration-dependent manner. Taken together, these results suggest that SRrp53 is a novel SR-related protein that has a role both in constitutive and in alternative splicing. ..
  27. Geissler R, Simkin A, Floss D, Patel R, Fogarty E, Scheller J, et al. A widespread sequence-specific mRNA decay pathway mediated by hnRNPs A1 and A2/B1. Genes Dev. 2016;30:1070-85 pubmed publisher
    ..We used RNA sequencing (RNA-seq) to confirm hnRNP A1 and A2/B1 motif-dependent roles genome-wide, profiling cells depleted of these factors singly and in combination...