Hnf1a

Summary

Gene Symbol: Hnf1a
Description: HNF1 homeobox A
Alias: AI323641, HNF1, HNF1-alpha, HNF1[a], Hnf-1, Hnf1alpha, LFB1, Tcf-1, Tcf1, hepatocyte nuclear factor 1-alpha, HNF-1-alpha, HNF-1A, hepatocyte nuclear factor 1, liver-specific transcription factor LF-B1, transcription factor 1
Species: mouse
Products:     Hnf1a

Top Publications

  1. Tiemessen M, Baert M, Schonewille T, Brugman M, Famili F, Salvatori D, et al. The nuclear effector of Wnt-signaling, Tcf1, functions as a T-cell-specific tumor suppressor for development of lymphomas. PLoS Biol. 2012;10:e1001430 pubmed publisher
    The HMG-box factor Tcf1 is required during T-cell development in the thymus and mediates the nuclear response to Wnt signals...
  2. Kuo C, Conley P, Hsieh C, Francke U, Crabtree G. Molecular cloning, functional expression, and chromosomal localization of mouse hepatocyte nuclear factor 1. Proc Natl Acad Sci U S A. 1990;87:9838-42 pubmed
    The homeodomain-containing transcription factor hepatocyte nuclear factor 1 (HNF-1) most likely plays an essential role during liver organogenesis by transactivating a family of greater than 15 predominantly hepatic genes...
  3. Galceran J, Farinas I, Depew M, Clevers H, Grosschedl R. Wnt3a-/--like phenotype and limb deficiency in Lef1(-/-)Tcf1(-/-) mice. Genes Dev. 1999;13:709-17 pubmed
    ..However, targeted gene inactivations of Lef1, Tcf1, or Tcf4 in the mouse do not produce phenotypes that mimic any known Wnt mutation...
  4. Shih D, Heimesaat M, Kuwajima S, Stein R, Wright C, Stoffel M. Profound defects in pancreatic beta-cell function in mice with combined heterozygous mutations in Pdx-1, Hnf-1alpha, and Hnf-3beta. Proc Natl Acad Sci U S A. 2002;99:3818-23 pubmed
    ..These studies also established polygenic mouse models for investigating the mechanisms contributing to beta-cell dysfunction in diabetes. ..
  5. Parrizas M, Maestro M, Boj S, Paniagua A, Casamitjana R, Gomis R, et al. Hepatic nuclear factor 1-alpha directs nucleosomal hyperacetylation to its tissue-specific transcriptional targets. Mol Cell Biol. 2001;21:3234-43 pubmed
    Mutations in the gene encoding hepatic nuclear factor 1-alpha (HNF1-alpha) cause a subtype of human diabetes resulting from selective pancreatic beta-cell dysfunction...
  6. D Angelo A, Bluteau O, Garcia Gonzalez M, Gresh L, Doyen A, Garbay S, et al. Hepatocyte nuclear factor 1alpha and beta control terminal differentiation and cell fate commitment in the gut epithelium. Development. 2010;137:1573-82 pubmed publisher
    ..b>Hnf1alpha and beta are closely related atypical homeoprotein transcription factors expressed in several epithelia, ..
  7. Boudreau F, Rings E, van Wering H, Kim R, Swain G, Krasinski S, et al. Hepatocyte nuclear factor-1 alpha, GATA-4, and caudal related homeodomain protein Cdx2 interact functionally to modulate intestinal gene transcription. Implication for the developmental regulation of the sucrase-isomaltase gene. J Biol Chem. 2002;277:31909-17 pubmed
    ..These findings imply a combinatory role of HNF-1 alpha, Cdx2, and GATA-4 for the time- and position-dependent regulation of SI transcription during development. ..
  8. Maestro M, Boj S, Luco R, Pierreux C, Cabedo J, Servitja J, et al. Hnf6 and Tcf2 (MODY5) are linked in a gene network operating in a precursor cell domain of the embryonic pancreas. Hum Mol Genet. 2003;12:3307-14 pubmed
    ..These findings define a precursor cellular stage of the embryonic pancreas and place Hnf1beta in a genetic hierarchy that regulates the generation of pancreatic endocrine cells. ..
  9. Gregorieff A, Grosschedl R, Clevers H. Hindgut defects and transformation of the gastro-intestinal tract in Tcf4(-/-)/Tcf1(-/-) embryos. EMBO J. 2004;23:1825-33 pubmed
    ..To gain new insight into the role of T-cell factors (or Tcf's) during development, we analysed Tcf4 and Tcf1 compound null embryos. These mutants showed severe caudal truncations, as well as duplications of the neural tube...

More Information

Publications89

  1. Kyrmizi I, Hatzis P, Katrakili N, Tronche F, Gonzalez F, Talianidis I. Plasticity and expanding complexity of the hepatic transcription factor network during liver development. Genes Dev. 2006;20:2293-305 pubmed
    ..The results illustrate the remarkable flexibility of a self-sustaining transcription factor network, built up by complex dominant and redundant regulatory motifs in developing hepatocytes. ..
  2. Pontoglio M, Sreenan S, Roe M, Pugh W, Ostrega D, Doyen A, et al. Defective insulin secretion in hepatocyte nuclear factor 1alpha-deficient mice. J Clin Invest. 1998;101:2215-22 pubmed
    ..These results provide further evidence in support of a key role for HNF-1alpha in the maintenance of normal beta cell function. ..
  3. Lee Y, Sauer B, Gonzalez F. Laron dwarfism and non-insulin-dependent diabetes mellitus in the Hnf-1alpha knockout mouse. Mol Cell Biol. 1998;18:3059-68 pubmed
    Mice deficient in hepatocyte nuclear factor 1 alpha (HNF-1alpha) were produced by use of the Cre-loxP recombination system...
  4. Wang L, Coffinier C, Thomas M, Gresh L, Eddu G, Manor T, et al. Selective deletion of the Hnf1beta (MODY5) gene in beta-cells leads to altered gene expression and defective insulin release. Endocrinology. 2004;145:3941-9 pubmed
    Hepatocyte nuclear factor 1alpha (HNF1alpha) and HNF1beta (or vHNF1) are closely related transcription factors expressed in liver, kidney, gut, and pancreatic beta-cells. Many HNF1 target genes are involved in carbohydrate metabolism...
  5. Yamagata K, Oda N, Kaisaki P, Menzel S, Furuta H, Vaxillaire M, et al. Mutations in the hepatocyte nuclear factor-1alpha gene in maturity-onset diabetes of the young (MODY3). Nature. 1996;384:455-8 pubmed
    ..have mutations in the gene encoding hepatocyte nuclear factor-1alpha (HNF-1alpha, which is encoded by the gene TCF1)...
  6. Pontoglio M, Barra J, Hadchouel M, Doyen A, Kress C, Bach J, et al. Hepatocyte nuclear factor 1 inactivation results in hepatic dysfunction, phenylketonuria, and renal Fanconi syndrome. Cell. 1996;84:575-85 pubmed
    b>HNF1 is a transcriptional activator of many hepatic genes including albumin, alpha1-antitrypsin, and alpha- and beta-fibrinogen. It is related to the homeobox gene family and is predominantly expressed in liver and kidney...
  7. Luco R, Maestro M, Sadoni N, Zink D, Ferrer J. Targeted deficiency of the transcriptional activator Hnf1alpha alters subnuclear positioning of its genomic targets. PLoS Genet. 2008;4:e1000079 pubmed publisher
    ..This was carried out with primary beta-cells and hepatocytes freshly isolated from mice lacking Hnf1alpha, an activator encoded by the most frequently mutated gene in human monogenic diabetes (MODY3)...
  8. Blumenfeld M, Maury M, Chouard T, Yaniv M, Condamine H. Hepatic nuclear factor 1 (HNF1) shows a wider distribution than products of its known target genes in developing mouse. Development. 1991;113:589-99 pubmed
    Hepatic nuclear factor 1 (HNF1) is a highly diverged homeoprotein that is crucial for transcription of many liver-specific genes including albumin...
  9. Pontoglio M, Prie D, Cheret C, Doyen A, Leroy C, Froguel P, et al. HNF1alpha controls renal glucose reabsorption in mouse and man. EMBO Rep. 2000;1:359-65 pubmed
    Recently it has been shown that dominant mutations in the human hepatocyte nuclear factor 1alpha (HNF1alpha) gene, encoding for a homeoprotein that is expressed in liver, kidney, pancreas and intestine, result in maturity onset diabetes ..
  10. Shih D, Screenan S, Munoz K, Philipson L, Pontoglio M, Yaniv M, et al. Loss of HNF-1alpha function in mice leads to abnormal expression of genes involved in pancreatic islet development and metabolism. Diabetes. 2001;50:2472-80 pubmed
    ..Our results indicate that loss of Hnf-1alpha function leads to altered expression of genes involved in glucose-stimulated insulin secretion, insulin synthesis, and beta-cell differentiation. ..
  11. Cereghini S, Ott M, Power S, Maury M. Expression patterns of vHNF1 and HNF1 homeoproteins in early postimplantation embryos suggest distinct and sequential developmental roles. Development. 1992;116:783-97 pubmed
    The homeoproteins HNF1 (LFB1/HNF1-A) and vHNF1 (LFB3/HNF1 beta) interact with an essential control element of a group of liver-specific genes...
  12. Shih D, Bussen M, Sehayek E, Ananthanarayanan M, Shneider B, Suchy F, et al. Hepatocyte nuclear factor-1alpha is an essential regulator of bile acid and plasma cholesterol metabolism. Nat Genet. 2001;27:375-82 pubmed
    ..of the young type 3 (MODY3) is caused by haploinsufficiency of hepatocyte nuclear factor-1alpha (encoded by TCF1). Tcf1-/- mice have type 2 diabetes, dwarfism, renal Fanconi syndrome, hepatic dysfunction and hypercholestrolemia...
  13. Hunter C, Maestro M, Raum J, Guo M, Thompson F, Ferrer J, et al. Hnf1? (MODY3) regulates ?-cell-enriched MafA transcription factor expression. Mol Endocrinol. 2011;25:339-47 pubmed publisher
    ..Here, we describe that MafA expression is controlled by hepatocyte nuclear factor 1-? (Hnf1?), the transcription factor gene mutated in the most common monoallelic form of maturity onset ..
  14. Weber B, Chi A, Chavez A, Yashiro Ohtani Y, Yang Q, Shestova O, et al. A critical role for TCF-1 in T-lineage specification and differentiation. Nature. 2011;476:63-8 pubmed publisher
    ..Our data suggest a model where Notch signals induce TCF-1, and TCF-1 in turn imprints the T-cell fate by upregulating expression of T-cell essential genes. ..
  15. Dukes I, Sreenan S, Roe M, Levisetti M, Zhou Y, Ostrega D, et al. Defective pancreatic beta-cell glycolytic signaling in hepatocyte nuclear factor-1alpha-deficient mice. J Biol Chem. 1998;273:24457-64 pubmed
    ..We conclude that hepatocyte nuclear factor-1alpha diabetes results from defective beta-cell glycolytic signaling, which is potentially correctable using substrates that bypass the defect. ..
  16. Bosse T, van Wering H, Gielen M, Dowling L, Fialkovich J, Piaseckyj C, et al. Hepatocyte nuclear factor-1alpha is required for expression but dispensable for histone acetylation of the lactase-phlorizin hydrolase gene in vivo. Am J Physiol Gastrointest Liver Physiol. 2006;290:G1016-24 pubmed
    ..markers and putative HNF-1alpha targets lactase-phlorizin hydrolase (LPH) and sucrase-isomaltase (SI) in hnf1alpha null mice...
  17. Hiraiwa H, Pan C, Lin B, Akiyama T, Gonzalez F, Chou J. A molecular link between the common phenotypes of type 1 glycogen storage disease and HNF1alpha-null mice. J Biol Chem. 2001;276:7963-7 pubmed
    ..g. growth retardation, hepatomegaly, hyperlipidemia, and renal dysfunction) are shared by Hnf1alpha(-/-) mice deficient of a transcriptional activator, hepatocyte nuclear factor 1alpha (HNF1alpha)...
  18. Yao J, Guihard P, Wu X, Blázquez Medela A, Spencer M, Jumabay M, et al. Vascular endothelium plays a key role in directing pulmonary epithelial cell differentiation. J Cell Biol. 2017;216:3369-3385 pubmed publisher
    ..Together, our results suggest that endothelial-epithelial interactions, maintained by MGP, are essential in pulmonary cell differentiation. ..
  19. Akiyama T, Ward J, Gonzalez F. Regulation of the liver fatty acid-binding protein gene by hepatocyte nuclear factor 1alpha (HNF1alpha). Alterations in fatty acid homeostasis in HNF1alpha-deficient mice. J Biol Chem. 2000;275:27117-22 pubmed
    Hepatocyte nuclear factor 1alpha (HNF1alpha)-null mice have enlarged fatty livers and alterations in the expression of genes encoding enzymes involved in the synthesis, catabolism, and transport of fatty acids...
  20. Galceran J, Miyashita Lin E, Devaney E, Rubenstein J, Grosschedl R. Hippocampus development and generation of dentate gyrus granule cells is regulated by LEF1. Development. 2000;127:469-82 pubmed
    ..Thus, LEF1 regulates the generation of dentate gyrus granule cells, and together with other LEF1/TCF proteins, the development of the hippocampus. ..
  21. Friedlander G, Runembert I, Vrtovsnik F, Terzi F. Renal tubular cells cultured from genetically modified animals. Exp Nephrol. 1999;7:407-12 pubmed
    ..These observations illustrate the interest and limits of the in vitro models for studying renal function in transgenic animals. ..
  22. Uchizono Y, Baldwin A, Sakuma H, Pugh W, Polonsky K, Hara M. Role of HNF-1alpha in regulating the expression of genes involved in cellular growth and proliferation in pancreatic beta-cells. Diabetes Res Clin Pract. 2009;84:19-26 pubmed publisher
    ..These results provide insights into the mechanisms whereby HNF-1alpha affects beta-cell function. ..
  23. Mishra L, Cai T, Levine A, Weng D, Mezey E, Mishra B, et al. Identification of elf1, a beta-spectrin, in early mouse liver development. Int J Dev Biol. 1998;42:221-4 pubmed
    ..5 hepatic tissue. These studies suggest that elf1 may play a role in the emergence of hepatocyte polarity during liver development. ..
  24. Nemer G, Nemer M. Transcriptional activation of BMP-4 and regulation of mammalian organogenesis by GATA-4 and -6. Dev Biol. 2003;254:131-48 pubmed
    ..They also raise the possibility that part of the early defects in GATA-4 and/or GATA-6 null embryos may be due to impaired BMP-4 signaling. ..
  25. Andrejko K, Raj N, Kim P, Cereda M, Deutschman C. IL-6 modulates sepsis-induced decreases in transcription of hepatic organic anion and bile acid transporters. Shock. 2008;29:490-6 pubmed
    ..We conclude that sepsis decreases the expression of three key hepatic genes via a transcriptional mechanism that is IL-6, Stat-3, and HNF-1alpha dependent. ..
  26. Yu H, Yu M, Li C, Zhan Y, Xu W, Li Y, et al. Specific expression and regulation of hepassocin in the liver and down-regulation of the correlation of HNF1alpha with decreased levels of hepassocin in human hepatocellular carcinoma. J Biol Chem. 2009;284:13335-47 pubmed publisher
    ..However, very little is known about the HPS transcription regulation mechanism. In this study, we identified HNF1alpha (hepatocyte nuclear factor-1alpha) as an important liver-specific cis-acting element for HPS using in vivo ..
  27. Kanazawa T, Konno A, Hashimoto Y, Kon Y. Hepatocyte nuclear factor 4 alpha is related to survival of the condensed mesenchyme in the developing mouse kidney. Dev Dyn. 2010;239:1145-54 pubmed publisher
    ..These results suggest the possibility that Hnf4alpha plays an important role in the regulation of the cell survival at the CM stage in nephrogenesis. ..
  28. Jochheim A, Hillemann T, Kania G, Scharf J, Attaran M, Manns M, et al. Quantitative gene expression profiling reveals a fetal hepatic phenotype of murine ES-derived hepatocytes. Int J Dev Biol. 2004;48:23-9 pubmed
    ..With sophisticated differentiation protocols, hepatic gene expression can be induced in a proportion of ES cells with gene expression patterns similar to early fetal liver. ..
  29. Mouchel N, Henstra S, McCarthy V, Williams S, Phylactides M, Harris A. HNF1alpha is involved in tissue-specific regulation of CFTR gene expression. Biochem J. 2004;378:909-18 pubmed
    ..In contrast, antisense inhibition of HNF1 alpha transcription decreased the CFTR mRNA levels...
  30. Lee Y, Magnuson M, Muppala V, Chen S. Liver-specific reactivation of the inactivated Hnf-1alpha gene: elimination of liver dysfunction to establish a mouse MODY3 model. Mol Cell Biol. 2003;23:923-32 pubmed
    Mice deficient in hepatocyte nuclear factor 1 alpha (HNF-1alpha) develop dwarfism, liver dysfunction, and type 2 diabetes mellitus. Liver dysfunction in HNF-1alpha-null mice includes severe hepatic glycogen accumulation and dyslipidemia...
  31. Faure A, Schmidt D, Watt S, Schwalie P, Wilson M, Xu H, et al. Cohesin regulates tissue-specific expression by stabilizing highly occupied cis-regulatory modules. Genome Res. 2012;22:2163-75 pubmed publisher
    ..Finally, we observe that the presence of mirrored CTCF binding events at promoters and their nearby cohesin-bound enhancers is associated with elevated expression levels. ..
  32. Cho S, Wu C, Nguyen D, Lin L, Chen M, Khan A, et al. A Novel miR-24-TCF1 Axis in Modulating Effector T Cell Responses. J Immunol. 2017;198:3919-3926 pubmed publisher
    ..article, we show that miR-24 drives the production of IFN-? and IL-17 in T cells at least in part through targeting TCF1, a transcription factor known for its role in limiting Th1 and Th17 immunity...
  33. Xu X, Yu B, Cai W, Huang Z. TCF1 deficiency ameliorates autoimmune lymphoproliferative syndrome (ALPS)-like phenotypes of lpr/lpr mice. Scand J Immunol. 2017;85:406-416 pubmed publisher
    ..b>TCF1 is a key effector in the canonical Wnt/?-catenin pathway, regulating the development, activation and function of T ..
  34. Shende V, Wu M, Singh A, Dong B, Kan C, Liu J. Reduction of circulating PCSK9 and LDL-C levels by liver-specific knockdown of HNF1α in normolipidemic mice. J Lipid Res. 2015;56:801-9 pubmed publisher
    The transcription factors hepatic nuclear factor (HNF)1α and HNF1β can bind to the HNF1 site on the proprotein convertase subtilisin/kexin type 9 (PCSK9) promoter to activate transcription in HepG2 cells...
  35. Kim F, Sing l A, Kaneko T, Bieman M, Stallwood N, Sadl V, et al. The vHNF1 homeodomain protein establishes early rhombomere identity by direct regulation of Kreisler expression. Mech Dev. 2005;122:1300-9 pubmed
    ..variant Hepatocyte Nuclear Factor 1 (vHNF1/HNF1beta/LF-3B) is transiently expressed in the r5/r6 domain of 0-10 somite stage embryos and a ..
  36. Lin W, Hu Y, Lee Y. Hepatocyte nuclear factor-1alpha regulates glucocorticoid receptor expression to control postnatal body growth. Am J Physiol Gastrointest Liver Physiol. 2008;295:G542-51 pubmed publisher
    ..We further demonstrated that HNF-1alpha modulated GR gene expression by directly transactivating the GR gene promoter via a cryptic regulatory element located 3 bp upstream of the translation start site in exon 2 of the GR gene locus. ..
  37. Kennedy M, Chalamalasetty R, Thomas S, Garriock R, Jailwala P, Yamaguchi T. Sp5 and Sp8 recruit β-catenin and Tcf1-Lef1 to select enhancers to activate Wnt target gene transcription. Proc Natl Acad Sci U S A. 2016;113:3545-50 pubmed publisher
    ..Because Sp5 is itself directly activated by Wnt signals, we propose that Sp5 is a Wnt/β-catenin pathway-specific transcript on factor that functions in a feed-forward loop to robustly activate select Wnt target genes. ..
  38. Tomomura M, Imamura Y, Tomomura A, Horiuchi M, Saheki T. Abnormal gene expression and regulation in the liver of jvs mice with systemic carnitine deficiency. Biochim Biophys Acta. 1994;1226:307-14 pubmed
    ..We suggest that elevated AP-1 binding induced by carnitine deficiency is closely connected with the abnormal gene expression in the liver. ..
  39. Serikawa T, Montagutelli X, Simon Chazottes D, Guenet J. Polymorphisms revealed by PCR with single, short-sized, arbitrary primers are reliable markers for mouse and rat gene mapping. Mamm Genome. 1992;3:65-72 pubmed
    ..From these experiments we conclude that, under precisely standardized PCR conditions, the DNA molecules amplified with these arbitrarily designed primers are useful and reliable markers for genetic mapping in both mouse and rat. ..
  40. Yi F, Pereira L, Hoffman J, Shy B, Yuen C, Liu D, et al. Opposing effects of Tcf3 and Tcf1 control Wnt stimulation of embryonic stem cell self-renewal. Nat Cell Biol. 2011;13:762-70 pubmed publisher
    ..Interestingly, both Tcf3-?-catenin and Tcf1-?-catenin interactions contributed to Wnt stimulation of self-renewal and gene expression, and the combination of ..
  41. Das S, Yu S, Sakamori R, Vedula P, Feng Q, Flores J, et al. Rab8a vesicles regulate Wnt ligand delivery and Paneth cell maturation at the intestinal stem cell niche. Development. 2015;142:2147-62 pubmed publisher
    ..Rab8a thus controls Wnt delivery in producing cells and is crucial for Paneth cell maturation. Our data highlight the profound tissue plasticity that occurs in response to stress induced by depletion of a stem cell niche signal. ..
  42. Driskell R, Goodheart M, Neff T, Liu X, Luo M, Moothart C, et al. Wnt3a regulates Lef-1 expression during airway submucosal gland morphogenesis. Dev Biol. 2007;305:90-102 pubmed
    ..early phases of SMG development and immunolocalization studies confirmed abundant expression of Tcf4, but not Tcf1 or Tcf3, at this stage...
  43. Smith S, Gasa R, Watada H, Wang J, Griffen S, German M. Neurogenin3 and hepatic nuclear factor 1 cooperate in activating pancreatic expression of Pax4. J Biol Chem. 2003;278:38254-9 pubmed
    ..In the current study we demonstrate that the HNF1alpha and Neurogenin3 binding sites are critical for activity of the region through synergy between the two proteins...
  44. Liu H, Ren H, Spear B. The mouse alpha-albumin (afamin) promoter is differentially regulated by hepatocyte nuclear factor 1? and hepatocyte nuclear factor 1?. DNA Cell Biol. 2011;30:137-47 pubmed publisher
    ..Here, we identify two hepatocyte nuclear factor 1 (HNF1)-binding sites in the AFM promoter that are highly conserved in different mammals...
  45. Glass D, Bialek P, Ahn J, Starbuck M, Patel M, Clevers H, et al. Canonical Wnt signaling in differentiated osteoblasts controls osteoclast differentiation. Dev Cell. 2005;8:751-64 pubmed
  46. Kazgan N, Metukuri M, Purushotham A, Lu J, Rao A, Lee S, et al. Intestine-specific deletion of SIRT1 in mice impairs DCoH2-HNF-1?-FXR signaling and alters systemic bile acid homeostasis. Gastroenterology. 2014;146:1006-16 pubmed publisher
    ..SIRT1 iKO mice had reduced intestinal farnesoid X receptor (FXR) signaling via hepatocyte nuclear factor 1? (HNF-1?) compared with controls, which reduced expression of the bile acid transporter genes Asbt and ..
  47. Ma X, Hu Y, Zhao Z, Zheng L, Qiu Y, Huang J, et al. Anti-inflammatory effects of propofol are mediated by apolipoprotein M in a hepatocyte nuclear factor-1?-dependent manner. Arch Biochem Biophys. 2013;533:1-10 pubmed publisher
    ..Therefore, our study may be useful in understanding the critical effect of propofol in patients with systemic inflammatory response syndrome. ..
  48. Jeevan Raj B, Gehrig J, Charmoy M, Chennupati V, Grandclement C, Angelino P, et al. The Transcription Factor Tcf1 Contributes to Normal NK Cell Development and Function by Limiting the Expression of Granzymes. Cell Rep. 2017;20:613-626 pubmed publisher
    The transcription factor Tcf1 is essential for the development of natural killer (NK) cells. However, its precise role has not been clarified...
  49. Boj S, Petrov D, Ferrer J. Epistasis of transcriptomes reveals synergism between transcriptional activators Hnf1alpha and Hnf4alpha. PLoS Genet. 2010;6:e1000970 pubmed publisher
    ..The transcription factors Hnf1alpha and Hnf4alpha control pancreatic islet beta-cell function and growth, and mutations in their genes cause closely ..
  50. Bussoli T, Kelly A, Steel K. Localization of the bronx waltzer (bv) deafness gene to mouse chromosome 5. Mamm Genome. 1997;8:714-7 pubmed
    ..bv maps 0.14 cM distal of the marker D5Mit209 and 1.14 cM proximal of the marker D5Mit188 in 701 backcross progeny. ..
  51. Feng H, Cheng A, Tsang D, Li M, Go M, Cheung Y, et al. Cell cycle-related kinase is a direct androgen receptor-regulated gene that drives ?-catenin/T cell factor-dependent hepatocarcinogenesis. J Clin Invest. 2011;121:3159-75 pubmed publisher
    ..Our results reveal a direct AR transcriptional target, CCRK, that promotes hepatocarcinogenesis through the upregulation of ?-catenin/TCF signaling. ..
  52. Kamiya A, Kinoshita T, Ito Y, Matsui T, Morikawa Y, Senba E, et al. Fetal liver development requires a paracrine action of oncostatin M through the gp130 signal transducer. EMBO J. 1999;18:2127-36 pubmed
    ..These results suggest a paracrine mechanism of hepatogenesis; blood cells, transiently expanding in the fetal liver, produce OSM to promote development of hepatocytes in vivo. ..
  53. Heibel S, Lopez G, Panglao M, Sodha S, Mariño Ramírez L, Tuchman M, et al. Transcriptional regulation of N-acetylglutamate synthase. PLoS ONE. 2012;7:e29527 pubmed publisher
    ..This provides molecular mechanism of regulation of ureagenesis in response to hormonal and dietary changes. ..
  54. Bonzo J, Patterson A, Krausz K, Gonzalez F. Metabolomics identifies novel Hnf1alpha-dependent physiological pathways in vivo. Mol Endocrinol. 2010;24:2343-55 pubmed publisher
    ..type 3 patients, these mice also suffer from Laron dwarfism and aminoaciduria, suggesting a role for hepatocyte nuclear factor 1? (Hnf1?) in pathophysiologies distinct from non-insulin-dependent (type 2) diabetes mellitus...
  55. Mendel D, Hansen L, Graves M, Conley P, Crabtree G. HNF-1 alpha and HNF-1 beta (vHNF-1) share dimerization and homeo domains, but not activation domains, and form heterodimers in vitro. Genes Dev. 1991;5:1042-56 pubmed
    ..These studies define a pair of homeo domain proteins that have the potential to interact to produce an embryologically complex pattern of gene expression. ..
  56. Jongjaroenprasert W, Chanprasertyothin S, Kongsuksai A, Bunnag P, Puavilai G, Ongphiphadhanakul B. Association of genetic variations near P2 promoter of the hepatocyte nuclear factor-4alpha gene and insulin secretion index in Thais. Acta Diabetol. 2007;44:227-32 pubmed
    ..The clinical features of all groups were similar. We demonstrated genotype TT at rs1884614, BMI, and waist circumference were significantly associated with insulin secretion index (P = 0.023) but not with diabetes phenotype. ..
  57. Oliver Krasinski J, Kasner M, Yang J, Crutchlow M, Rustgi A, Kaestner K, et al. The diabetes gene Pdx1 regulates the transcriptional network of pancreatic endocrine progenitor cells in mice. J Clin Invest. 2009;119:1888-98 pubmed publisher
  58. Anderson A, Banks K, Pontoglio M, Yaniv M, McLachlan A. Alpha/beta interferon differentially modulates the clearance of cytoplasmic encapsidated replication intermediates and nuclear covalently closed circular hepatitis B virus (HBV) DNA from the livers of hepatocyte nuclear factor 1alpha-null HBV transge. J Virol. 2005;79:11045-52 pubmed
    ..address this issue, the stability of HBV CCC DNA in response to alpha/beta interferon induction was examined in HNF1alpha-null HBV transgenic mice...
  59. Ruvinsky I, Silver L. Newly identified paralogous groups on mouse chromosomes 5 and 11 reveal the age of a T-box cluster duplication. Genomics. 1997;40:262-6 pubmed
    ..This work facilitates our understanding of the status of the T-box gene family in different vertebrate lineages and also defines a novel paralogy group within the mouse genome. ..
  60. Han W, He L, Cao B, Zhao X, Zhang K, Li Y, et al. Differential expression of LEF1/TCFs family members in colonic carcinogenesis. Mol Carcinog. 2017;56:2372-2381 pubmed publisher
    Lef1/Tcfs family, which includes Lef1, Tcf1, Tcf3, and Tcf4, is required for the transcriptional activation induced by ?-catenin. However, whether all the members play the same role in colon carcinogenesis is not clear...
  61. Torres Padilla M, Zernicka Goetz M. Role of TIF1alpha as a modulator of embryonic transcription in the mouse zygote. J Cell Biol. 2006;174:329-38 pubmed
    ..These studies indicate that TIF1alpha is a factor that modulates the expression of a set of genes during the first wave of genome activation in the mouse embryo. ..
  62. Ohki T, Sato Y, Yoshizawa T, Yamamura K, Yamada K, Yamagata K. Identification of hepatocyte growth factor activator (Hgfac) gene as a target of HNF1? in mouse ?-cells. Biochem Biophys Res Commun. 2012;425:619-24 pubmed publisher
    b>HNF1? is a transcription factor that is expressed in pancreatic ?-cells and mutations of the HNF1? gene cause a form of monogenic diabetes...
  63. Bheda A, Yue W, Gullapalli A, Whitehurst C, Liu R, Pagano J, et al. Positive reciprocal regulation of ubiquitin C-terminal hydrolase L1 and beta-catenin/TCF signaling. PLoS ONE. 2009;4:e5955 pubmed publisher
  64. Grimm A, Brace C, Wang T, Stormo G, Imai S. A nutrient-sensitive interaction between Sirt1 and HNF-1? regulates Crp expression. Aging Cell. 2011;10:305-17 pubmed publisher
    ..These findings reveal a novel nutrient-dependent interaction between Sirt1 and HNF-1? and provide important insight into the molecular mechanism by which Sirt1 mediates the anti-aging effects of diet restriction. ..
  65. Kikuchi R, Yagi S, Kusuhara H, Imai S, Sugiyama Y, Shiota K. Genome-wide analysis of epigenetic signatures for kidney-specific transporters. Kidney Int. 2010;78:569-77 pubmed publisher
    ..This process is thought to influence the ability of hepatocyte nuclear factor 1 (HNF1) to transactivate organic anion transporter expression in the liver and kidney...
  66. Harries L, Brown J, Gloyn A. Species-specific differences in the expression of the HNF1A, HNF1B and HNF4A genes. PLoS ONE. 2009;4:e7855 pubmed publisher
    The HNF1A, HNF1B and HNF4A genes are part of an autoregulatory network in mammalian pancreas, liver, kidney and gut...
  67. Tomassetti A, De Santis G, Castellano G, Miotti S, Mazzi M, Tomasoni D, et al. Variant HNF1 modulates epithelial plasticity of normal and transformed ovary cells. Neoplasia. 2008;10:1481-92, 3p following 1492 pubmed
    ..The variant isoform of the hepatocyte nuclear factor 1 (vHNF1) is a transcription factor involved in the development of tissues derived from the müllerian ..
  68. Szpirer C, Riviere M, Cortese R, Nakamura T, Islam M, Levan G, et al. Chromosomal localization in man and rat of the genes encoding the liver-enriched transcription factors C/EBP, DBP, and HNF1/LFB-1 (CEBP, DBP, and transcription factor 1, TCF1, respectively) and of the hepatocyte growth factor/scatter factor gene (HGF. Genomics. 1992;13:293-300 pubmed
    ..binding protein), DBP (D site of albumin promoter binding protein), and HNF1/LFB-1 (designated transcription factor 1, gene symbol: TCF1), and of the hepatocyte growth factor gene, which is identical to the mitogenic and ..
  69. Sirard C, de la Pompa J, Elia A, Itie A, Mirtsos C, Cheung A, et al. The tumor suppressor gene Smad4/Dpc4 is required for gastrulation and later for anterior development of the mouse embryo. Genes Dev. 1998;12:107-19 pubmed
    ..Rescued embryos show severe anterior truncations, indicating a second important role for Smad4 in anterior patterning during embryogenesis. ..
  70. Kamiya A, Inoue Y, Kodama T, Gonzalez F. Hepatocyte nuclear factors 1alpha and 4alpha control expression of proline oxidase in adult liver. FEBS Lett. 2004;578:63-8 pubmed
    Adult liver functions are regulated by several hepatocyte nuclear factors (HNFs). HNF4alpha and HNF1alpha are involved in metabolic functions in the liver...
  71. Kueh H, Yui M, Ng K, Pease S, Zhang J, Damle S, et al. Asynchronous combinatorial action of four regulatory factors activates Bcl11b for T cell commitment. Nat Immunol. 2016;17:956-65 pubmed publisher
    ..Despite their necessity for Bcl11b expression, these inputs act in a stage-specific manner, providing a multitiered mechanism for developmental gene regulation. ..
  72. Zha H, Remmers E, Szpirer C, Szpirer J, Zhang H, Kozak C, et al. The epimorphin gene is highly conserved among humans, mice, and rats and maps to human chromosome 7, mouse chromosome 5, and rat chromosome 12. Genomics. 1996;37:386-9 pubmed
    ..The mouse and human homologs of this gene were localized on mouse chromosome 5 and human chromosome 7 by linkage analysis and chromosomal in situ hybridization, respectively. ..
  73. Duncan S. Transcriptional regulation of liver development. Dev Dyn. 2000;219:131-42 pubmed
    ..The picture that emerges is that specific transcription factors use novel mechanisms to orchestrate changes in gene expression patterns that ultimately direct cell differentiation. ..
  74. Kovalovsky D, Yu Y, Dose M, Emmanouilidou A, Konstantinou T, Germar K, et al. Beta-catenin/Tcf determines the outcome of thymic selection in response to alphabetaTCR signaling. J Immunol. 2009;183:3873-84 pubmed publisher
    ..These observations are consistent with beta-catenin/Tcf signaling acting as a switch that determines the outcome of thymic selection downstream the alphabetaTCR cascade. ..
  75. Bonner C, Farrelly A, Concannon C, Dussmann H, Baquie M, Virard I, et al. Bone morphogenetic protein 3 controls insulin gene expression and is down-regulated in INS-1 cells inducibly expressing a hepatocyte nuclear factor 1A-maturity-onset diabetes of the young mutation. J Biol Chem. 2011;286:25719-28 pubmed publisher
    Inactivating mutations in the transcription factor hepatocyte nuclear factor (HNF) 1A cause HNF1A-maturity-onset diabetes of the young (HNF1A-MODY), the most common monogenic form of diabetes...
  76. Yu S, Li F, Xing S, Zhao T, Peng W, Xue H. Hematopoietic and Leukemic Stem Cells Have Distinct Dependence on Tcf1 and Lef1 Transcription Factors. J Biol Chem. 2016;291:11148-60 pubmed publisher
    ..b>Tcf1 and Lef1 transcription factors are expressed in HSCs, and targeting both factors modestly expanded the size of the ..
  77. Poll A, Pierreux C, Lokmane L, Haumaitre C, Achouri Y, Jacquemin P, et al. A vHNF1/TCF2-HNF6 cascade regulates the transcription factor network that controls generation of pancreatic precursor cells. Diabetes. 2006;55:61-9 pubmed
    ..This enhancer contains functional binding sites for the tissue-specific factors of the forkhead box A and HNF1 families...
  78. Mendel D, Khavari P, Conley P, Graves M, Hansen L, Admon A, et al. Characterization of a cofactor that regulates dimerization of a mammalian homeodomain protein. Science. 1991;254:1762-7 pubmed
    ..These results indicate that DCoH regulates formation of transcriptionally active tetrameric complexes and may contribute to the developmental specificity of the complex. ..
  79. Gragnoli C, Lindner T, Cockburn B, Kaisaki P, Gragnoli F, Marozzi G, et al. Maturity-onset diabetes of the young due to a mutation in the hepatocyte nuclear factor-4 alpha binding site in the promoter of the hepatocyte nuclear factor-1 alpha gene. Diabetes. 1997;46:1648-51 pubmed
    ..Moreover, it indicates that both the promoter and coding regions of the HNF-1 alpha gene should be screened for mutations in subjects thought to have MODY because of mutations in this gene. ..
  80. de Simone V, De Magistris L, Lazzaro D, Gerstner J, Monaci P, Nicosia A, et al. LFB3, a heterodimer-forming homeoprotein of the LFB1 family, is expressed in specialized epithelia. EMBO J. 1991;10:1435-43 pubmed
    ..The first 315 amino acids of LFB3 are highly homologous to the DNA binding domain of LFB1, a regulatory protein involved in the expression of several liver-specific genes...