Hmx1

Summary

Gene Symbol: Hmx1
Description: H6 homeobox 1
Alias: Nkx5-3, H6 homeo box 1, homeobox protein H6, homeobox protein HMX1
Species: mouse

Top Publications

  1. ncbi Localization of serine kinases, SRPK1 (SFRSK1) and SRPK2 (SFRSK2), specific for the SR family of splicing factors in mouse and human chromosomes
    H Y Wang
    Department of Medicine, Department of Pathology, University of California at San Diego, 9500 Gilman Drive, La Jolla, California, 92093 0651, USA
    Genomics 57:310-5. 1999
  2. ncbi Identification of the minimal promoter region of the mouse NKX5-3, a transcription factor implicated in eye development
    Olivia Nichini
    Institute for Research in Ophthalmology, Sion, Switzerland
    Gene 411:10-8. 2008
  3. ncbi Mouse H6 Homeobox 1 (Hmx1) mutations cause cranial abnormalities and reduced body mass
    Robert J Munroe
    Department of Biomedical Sciences, Cornell University, Ithaca, New York 14853, USA
    BMC Dev Biol 9:27. 2009
  4. ncbi Mutation in the human homeobox gene NKX5-3 causes an oculo-auricular syndrome
    Daniel F Schorderet
    Institut de Recherche en Ophtalmologie, 1950 Sion, Switzerland
    Am J Hum Genet 82:1178-84. 2008
  5. ncbi Inner ear and maternal reproductive defects in mice lacking the Hmx3 homeobox gene
    W Wang
    Brookdale Center for Development and Molecular Biology, Mount Sinai School of Medicine, New York, NY 10029 6574, USA
    Development 125:621-34. 1998
  6. ncbi Cloning, characterization, and mapping of the mouse homeobox gene Hmx1
    K Yoshiura
    Department of Pediatrics, University of Iowa, Iowa City, Iowa 52242, USA
    Genomics 50:61-8. 1998
  7. ncbi Random mutagenesis of proximal mouse chromosome 5 uncovers predominantly embryonic lethal mutations
    Lawriston Wilson
    The Jackson Laboratory, Bar Harbor, Maine 04609, USA
    Genome Res 15:1095-105. 2005
  8. ncbi Postnatal lethality in mice lacking the Sax2 homeobox gene homologous to Drosophila S59/slouch: evidence for positive and negative autoregulation
    Ruth Simon
    Brookdale Center for Developmental and Molecular Biology, Mount Sinai School of Medicine, One Gustave L Levy Place, New York, NY 10029 6574, USA
    Mol Cell Biol 23:9046-60. 2003
  9. ncbi Hmx: an evolutionary conserved homeobox gene family expressed in the developing nervous system in mice and Drosophila
    W Wang
    Brookdale Center for Developmental and Molecular Biology, Mount Sinai School of Medicine, One Gustave L Levy Place, New York, NY 10029 6574, USA
    Mech Dev 99:123-37. 2000
  10. ncbi Mapping and developmental expression analysis of the WD-repeat gene Preb
    C L Taylor Clelland
    Department of Physiology and Biophysics, Brookdale Center for Developmental and Molecular Biology, Mount Sinai School of Medicine, One Gustave L Levy Place, New York, NY, 10029 6574, USA
    Genomics 63:391-9. 2000

Scientific Experts

  • Daniel F Schorderet
  • Robert J Munroe
  • W Wang
  • Olivia Nichini
  • T Lufkin
  • Lawriston Wilson
  • Ruth Simon
  • K Yoshiura
  • C L Taylor Clelland
  • H Y Wang
  • John C Schimenti
  • Yung-Hao Ching
  • Maja Bucan
  • Gareth Howell
  • Yung Hao Ching
  • Michael Farias
  • Suzanne A Hartford
  • Hongguang Shao
  • N J Leysens
  • J C Murray
  • Thomas Lufkin
  • L Craciun
  • C Bancroft
  • M Frasch
  • P Lo
  • H S Stadler
  • J R Bermingham
  • K C Arden
  • A D Boyer
  • C S Viars
  • X D Fu
  • W Lin
  • T Van de Water
  • R S Reiter
  • J Murray
  • P J Goodfellow
  • M Solursh
  • R M Mentzer
  • C A Alegre
  • S P Nolan

Detail Information

Publications13

  1. ncbi Localization of serine kinases, SRPK1 (SFRSK1) and SRPK2 (SFRSK2), specific for the SR family of splicing factors in mouse and human chromosomes
    H Y Wang
    Department of Medicine, Department of Pathology, University of California at San Diego, 9500 Gilman Drive, La Jolla, California, 92093 0651, USA
    Genomics 57:310-5. 1999
    ..1 (a region of conserved synteny to mouse Chromosome 5). In addition, we also found multiple SRPK-related sequences on other human chromosomes, one of which appears to correspond to a SRPK2 pseudogene on human chromosome 8...
  2. ncbi Identification of the minimal promoter region of the mouse NKX5-3, a transcription factor implicated in eye development
    Olivia Nichini
    Institute for Research in Ophthalmology, Sion, Switzerland
    Gene 411:10-8. 2008
    ..Altogether, these results demonstrated that the immediate upstream region of Nkx5-3 gene possessed a strong intrinsic promoter activity in vitro, suggesting a potential role in Nkx5-3 transcription in vivo...
  3. ncbi Mouse H6 Homeobox 1 (Hmx1) mutations cause cranial abnormalities and reduced body mass
    Robert J Munroe
    Department of Biomedical Sciences, Cornell University, Ithaca, New York 14853, USA
    BMC Dev Biol 9:27. 2009
    The H6 homeobox genes Hmx1, Hmx2, and Hmx3 (also known as Nkx5-3; Nkx5-2 and Nkx5-1, respectively), compose a family within the NKL subclass of the ANTP class of homeobox genes...
  4. ncbi Mutation in the human homeobox gene NKX5-3 causes an oculo-auricular syndrome
    Daniel F Schorderet
    Institut de Recherche en Ophtalmologie, 1950 Sion, Switzerland
    Am J Hum Genet 82:1178-84. 2008
    ..Morpholino knockdown expression of the zebrafish nkx5-3 induced microphthalmia and disorganization of the developing retina, thus confirming that this gene represents an additional member implicated in axial patterning of the retina...
  5. ncbi Inner ear and maternal reproductive defects in mice lacking the Hmx3 homeobox gene
    W Wang
    Brookdale Center for Development and Molecular Biology, Mount Sinai School of Medicine, New York, NY 10029 6574, USA
    Development 125:621-34. 1998
    ..The three members of the murine Hmx family, designated Hmx1, Hmx2 and Hmx3, are expressed in tissues that suggest a common functional role in sensory organ development and ..
  6. ncbi Cloning, characterization, and mapping of the mouse homeobox gene Hmx1
    K Yoshiura
    Department of Pediatrics, University of Iowa, Iowa City, Iowa 52242, USA
    Genomics 50:61-8. 1998
    ..We previously isolated the human HMX1 (H6) gene, a novel homeobox-containing gene of the HMX family, from a human embryonic craniofacial cDNA library...
  7. ncbi Random mutagenesis of proximal mouse chromosome 5 uncovers predominantly embryonic lethal mutations
    Lawriston Wilson
    The Jackson Laboratory, Bar Harbor, Maine 04609, USA
    Genome Res 15:1095-105. 2005
    ..By pooling the data from this and other region-specific mutagenesis projects, we calculate that the mouse genome contains approximately 3479-4825 embryonic lethal genes, or about 13.7%-19% of all genes...
  8. ncbi Postnatal lethality in mice lacking the Sax2 homeobox gene homologous to Drosophila S59/slouch: evidence for positive and negative autoregulation
    Ruth Simon
    Brookdale Center for Developmental and Molecular Biology, Mount Sinai School of Medicine, One Gustave L Levy Place, New York, NY 10029 6574, USA
    Mol Cell Biol 23:9046-60. 2003
    ..Intriguingly, our studies also demonstrated a striking autoregulation of the Sax2 gene in both positive- and negative-feedback mechanisms depending on the specific cell type expressing Sax2...
  9. ncbi Hmx: an evolutionary conserved homeobox gene family expressed in the developing nervous system in mice and Drosophila
    W Wang
    Brookdale Center for Developmental and Molecular Biology, Mount Sinai School of Medicine, One Gustave L Levy Place, New York, NY 10029 6574, USA
    Mech Dev 99:123-37. 2000
    ..three genes to previously identified genes in sea urchin, chick and human, as well as the recently cloned murine Hmx1 gene, and the low homology to other homeobox genes indicate that the Hmx genes comprise a novel gene family...
  10. ncbi Mapping and developmental expression analysis of the WD-repeat gene Preb
    C L Taylor Clelland
    Department of Physiology and Biophysics, Brookdale Center for Developmental and Molecular Biology, Mount Sinai School of Medicine, One Gustave L Levy Place, New York, NY, 10029 6574, USA
    Genomics 63:391-9. 2000
    ..Preb maps to the proximal end of chromosome 5 in mouse, near the Hmx1 homeobox gene...
  11. ncbi Assignment of the murine Hmx1 homeobox gene to the proximal region of mouse chromosome 5
    W Wang
    Brookdale Center for Developmental and Molecular Biology, Mount Sinai School of Medicine, New York, New York 10029-6574, USA
    Mamm Genome 8:869-70. 1997
  12. ncbi Phylogenetic conservation and physical mapping of members of the H6 homeobox gene family
    H S Stadler
    University of Iowa, Department of Biological Sciences, Iowa City 52242, USA
    Mamm Genome 6:383-8. 1995
    ..melanogaster (fruit fly)...
  13. ncbi The effects of dopamine and isoproterenol on the pulmonary circulation
    R M Mentzer
    J Thorac Cardiovasc Surg 71:807-14. 1976
    ..If these findings can be extrapolated to man, isoproterenol may be the preferred inotropic agent in patients with an elevated pulmonary vascular resistance...