Hist2h4

Summary

Gene Symbol: Hist2h4
Description: histone cluster 2, H4
Alias: X04652, histone 2, H4, histone H4
Species: mouse

Top Publications

  1. pmc A signal regulating mouse histone H4 mRNA levels in a mammalian cell cycle mutant and sequences controlling RNA 3' processing are both contained within the same 80-bp fragment
    C Stauber
    EMBO J 5:3297-303. 1986
  2. pmc The double-histone-acetyltransferase complex ATAC is essential for mammalian development
    Sebastián Guelman
    Department of Pathology, Genentech Inc, 1 DNA Way MS 72B, South San Francisco, CA 94080, USA
    Mol Cell Biol 29:1176-88. 2009
  3. pmc Modulation of smooth muscle gene expression by association of histone acetyltransferases and deacetylases with myocardin
    Dongsun Cao
    Department of Molecular Biology, University of Texas Southwestern Medical Center, 6000 Harry Hines Boulevard, Dallas, TX 75390 9148, USA
    Mol Cell Biol 25:364-76. 2005
  4. pmc Specific contacts between mammalian U7 snRNA and histone precursor RNA are indispensable for the in vitro 3' RNA processing reaction
    M Cotten
    Research Institute of Molecular Pathology, Vienna, Austria
    EMBO J 7:801-8. 1988
  5. ncbi Structure and expression in L-cells of a cloned H4 histone gene of the mouse
    A Seiler-Tuyns
    J Mol Biol 151:607-25. 1981
  6. pmc Adipose is a conserved dosage-sensitive antiobesity gene
    Jae Myoung Suh
    Department of Developmental Biology, University of Texas Southwestern Medical Center, 6000 Harry Hines Boulevard, NB5 118, Dallas, TX 75390 9133, USA
    Cell Metab 6:195-207. 2007
  7. pmc The WWOX tumor suppressor is essential for postnatal survival and normal bone metabolism
    Rami I Aqeilan
    Department of Molecular Virology, Immunology, and Medical Genetics, Human Cancer Genetics Program and Comprehensive Cancer Center, Ohio State University, Columbus, OH 43210, USA
    J Biol Chem 283:21629-39. 2008
  8. pmc The histone gene activator HINFP is a nonredundant cyclin E/CDK2 effector during early embryonic cell cycles
    Ronglin Xie
    Department of Cell Biology and Cancer Center, University of Massachusetts Medical School, 55 Lake Avenue North, Worcester, MA 01655, USA
    Proc Natl Acad Sci U S A 106:12359-64. 2009
  9. pmc Functional coupling of transcription factor HiNF-P and histone H4 gene expression during pre- and post-natal mouse development
    Li Jun Liu
    Department of Cell Biology and Cancer Center, University of Massachusetts Medical School, Worcester, 01655, USA
    Gene 483:1-10. 2011

Scientific Experts

  • Rami I Aqeilan
  • Li Jun Liu
  • Ronglin Xie
  • Sadiq Hussain
  • Andre J Van Wijnen
  • Janet L Stein
  • Jane B Lian
  • Gary S Stein
  • Stephen N Jones
  • Sebastián Guelman
  • Jae Myoung Suh
  • Dongsun Cao
  • Jaime Rivera-Perez
  • Ricardo Medina
  • Margaretha van der Deen
  • Jennie R Lill
  • Jiping Zha
  • Marilyn Keeler
  • Victoria Pham
  • Jaime A Rivera-Perez
  • Ying Zhang
  • Sakthi Sundararajan
  • Jiansheng Wu
  • Jennifer Colby
  • Prachi Ghule
  • Kenji Kozuka
  • Mark J Solloway
  • Partha Mitra
  • Yifan Mao
  • John Wang
  • Jin Seo
  • Daniel Zeve
  • Michael Wang
  • Zack Salo
  • Robert Li
  • Renee McKay
  • Jonathan M Graff
  • Da Zhi Wang
  • Eric N Olson
  • Chun Li Zhang
  • Shijie Li
  • Weibing Xing
  • Jiyeon Oh
  • James A Richardson
  • Zhigao Wang
  • A Seiler-Tuyns
  • M L Birnstiel
  • C Stauber
  • M Cotten
  • A Vasserot
  • B Luscher
  • D Schumperli
  • O Gick
  • E Lotscher
  • G Schaffner
  • R Eckner

Detail Information

Publications9

  1. pmc A signal regulating mouse histone H4 mRNA levels in a mammalian cell cycle mutant and sequences controlling RNA 3' processing are both contained within the same 80-bp fragment
    C Stauber
    EMBO J 5:3297-303. 1986
    Fragments from the 3' end of a mouse histone H4 gene, when introduced into transcription units controlled by the SV40 early promoter, yield correctly processed RNA with histone-specific 3' ends, both in monkey and mouse cell lines...
  2. pmc The double-histone-acetyltransferase complex ATAC is essential for mammalian development
    Sebastián Guelman
    Department of Pathology, Genentech Inc, 1 DNA Way MS 72B, South San Francisco, CA 94080, USA
    Mol Cell Biol 29:1176-88. 2009
    ..Recombinant ATAC2 has a weak HAT activity directed to histone H4. Moreover, depletion of ATAC2 results in the disassembly of the complex, indicating that ATAC2 not only carries ..
  3. pmc Modulation of smooth muscle gene expression by association of histone acetyltransferases and deacetylases with myocardin
    Dongsun Cao
    Department of Molecular Biology, University of Texas Southwestern Medical Center, 6000 Harry Hines Boulevard, Dallas, TX 75390 9148, USA
    Mol Cell Biol 25:364-76. 2005
    ..These findings point to myocardin as a nexus for positive and negative regulation of smooth muscle gene expression by changes in chromatin acetylation...
  4. pmc Specific contacts between mammalian U7 snRNA and histone precursor RNA are indispensable for the in vitro 3' RNA processing reaction
    M Cotten
    Research Institute of Molecular Pathology, Vienna, Austria
    EMBO J 7:801-8. 1988
    ..These experiments identify a set of specific contacts between mammalian U7 and histone precursor RNA which is indispensable for the maturation reaction...
  5. ncbi Structure and expression in L-cells of a cloned H4 histone gene of the mouse
    A Seiler-Tuyns
    J Mol Biol 151:607-25. 1981
  6. pmc Adipose is a conserved dosage-sensitive antiobesity gene
    Jae Myoung Suh
    Department of Developmental Biology, University of Texas Southwestern Medical Center, 6000 Harry Hines Boulevard, NB5 118, Dallas, TX 75390 9133, USA
    Cell Metab 6:195-207. 2007
    ..Thus Adp appears to be involved in an ancient pathway that regulates fat accumulation...
  7. pmc The WWOX tumor suppressor is essential for postnatal survival and normal bone metabolism
    Rami I Aqeilan
    Department of Molecular Virology, Immunology, and Medical Genetics, Human Cancer Genetics Program and Comprehensive Cancer Center, Ohio State University, Columbus, OH 43210, USA
    J Biol Chem 283:21629-39. 2008
    ..Our results demonstrate an essential requirement for the WWOX tumor suppressor in postnatal survival, growth, and metabolism and suggest a central role for WWOX in regulation of bone tissue formation...
  8. pmc The histone gene activator HINFP is a nonredundant cyclin E/CDK2 effector during early embryonic cell cycles
    Ronglin Xie
    Department of Cell Biology and Cancer Center, University of Massachusetts Medical School, 55 Lake Avenue North, Worcester, MA 01655, USA
    Proc Natl Acad Sci U S A 106:12359-64. 2009
    ..cyclin E/cyclin-dependent kinase 2 (CDK2) responsive coactivator p220(NPAT) is a key regulator of multiple human histone H4 genes that encode a major subunit of the nucleosome...
  9. pmc Functional coupling of transcription factor HiNF-P and histone H4 gene expression during pre- and post-natal mouse development
    Li Jun Liu
    Department of Cell Biology and Cancer Center, University of Massachusetts Medical School, Worcester, 01655, USA
    Gene 483:1-10. 2011
    Transcription factor Histone Nuclear Factor P (HiNF-P; gene symbol Hinfp) mediates cell cycle control of histone H4 gene expression to support the packaging of newly replicated DNA as chromatin...