Gene Symbol: Higd1a
Description: HIG1 domain family, member 1A
Alias: 2210020B17Rik, 7420700H20Rik, AI303276, AW049839, HIMP1, Hig1, HIG1 domain family member 1A, mitochondrial, hypoxia induced gene 1, hypoxia-inducible gene 1 protein
Wang J, Cao Y, Chen Y, Chen Y, Gardner P, Steiner D. Pancreatic beta cells lack a low glucose and O2-inducible mitochondrial protein that augments cell survival. Proc Natl Acad Sci U S A. 2006;103:10636-41 pubmed
..In efforts to identify important differences in gene expression in alpha vs. beta cells, a gene termed HIMP1 (Hypoglycemia/hypoxia Inducible Mitochondrial Protein, or HIG1) has been cloned from an alpha cell cDNA library...
An H, Shin H, Jo S, Kim Y, Lee J, Paik S, et al
. The survival effect of mitochondrial Higd-1a is associated with suppression of cytochrome C release and prevention of caspase activation. Biochim Biophys Acta. 2011;1813:2088-98 pubmed publisher
..Together these observations indicate that Higd-1a is induced by hypoxia in a HIF-dependent manner and its anti-apoptotic effect results from inhibiting cytochrome C release and reducing caspase activities. ..
Chen Y, Taylor E, Dephoure N, Heo J, Tonhato A, Papandreou I, et al
. Identification of a protein mediating respiratory supercomplex stability. Cell Metab. 2012;15:348-60 pubmed publisher
..We suggest that Rcf1 is a member of an evolutionarily conserved protein family that acts to promote respiratory supercomplex assembly and activity. ..
Ameri K, Rajah A, Nguyen V, Sanders T, Jahangiri A, Delay M, et al
. Nuclear localization of the mitochondrial factor HIGD1A during metabolic stress. PLoS ONE. 2013;8:e62758 pubmed publisher
..Hypoxia-inducible gene domain 1A (HIGD1A) is a mitochondrial protein regulated by Hypoxia-inducible Factor-1? (HIF1?)...
Miyata K, Yasukawa T, Fukuda M, Takeuchi T, Yamazaki K, Sakumi K, et al
. Induction of apoptosis and cellular senescence in mice lacking transcription elongation factor, Elongin A. Cell Death Differ. 2007;14:716-26 pubmed
..Taken together, our results suggest that Elongin A is required for the transcription of genes essential for early embryonic development and downregulation of its activity is tightly associated with cellular senescence. ..
Ameri K, Jahangiri A, Rajah A, Tormos K, Nagarajan R, Pekmezci M, et al
. HIGD1A Regulates Oxygen Consumption, ROS Production, and AMPK Activity during Glucose Deprivation to Modulate Cell Survival and Tumor Growth. Cell Rep. 2015;: pubmed publisher
Hypoxia-inducible gene domain family member 1A (HIGD1A) is a survival factor induced by hypoxia-inducible factor 1 (HIF-1)...