Hgf

Summary

Gene Symbol: Hgf
Description: hepatocyte growth factor
Alias: C230052L06Rik, HGF/SF, NK1, NK2, SF/HGF, hepatocyte growth factor, hepatopoietin-A, scatter factor
Species: mouse
Products:     Hgf

Top Publications

  1. Rong S, Bodescot M, Blair D, Dunn J, Nakamura T, Mizuno K, et al. Tumorigenicity of the met proto-oncogene and the gene for hepatocyte growth factor. Mol Cell Biol. 1992;12:5152-8 pubmed
    The met proto-oncogene is the tyrosine kinase growth factor receptor for hepatocyte growth factor/scatter factor (HGF/SF). It was previously shown that, like the oncogenic tpr-met, the mouse met proto-oncogene transforms NIH 3T3 cells...
  2. Eferl R, Sibilia M, Hilberg F, Fuchsbichler A, Kufferath I, Guertl B, et al. Functions of c-Jun in liver and heart development. J Cell Biol. 1999;145:1049-61 pubmed
  3. Garcia Ocana A, Takane K, Syed M, Philbrick W, Vasavada R, Stewart A. Hepatocyte growth factor overexpression in the islet of transgenic mice increases beta cell proliferation, enhances islet mass, and induces mild hypoglycemia. J Biol Chem. 2000;275:1226-32 pubmed
    b>Hepatocyte growth factor (HGF) is produced in pancreatic mesenchyme-derived cells and in islet cells. In vitro, HGF increases the insulin content and proliferation of islets...
  4. Yoon Y, Lee Y, Choi J, Cho M, Kang J. Coordinated induction of cyclooxygenase-2/prostaglandin E2 and hepatocyte growth factor by apoptotic cells prevents lung fibrosis. J Leukoc Biol. 2013;94:1037-49 pubmed publisher
    Apoptotic cell instillation after bleomycin induces persistent HGF production and protects from pulmonary fibrosis, but the underlying mechanism remains unclear...
  5. Park H, Choi Y, Cho Y, Henson P, Kang J. RhoA-mediated signaling up-regulates hepatocyte growth factor gene and protein expression in response to apoptotic cells. J Leukoc Biol. 2011;89:399-411 pubmed publisher
    Clearance of apoptotic cells by macrophages induces HGF secretion. We examined the regulatory mechanisms of HGF mRNA and protein expression in macrophages upon exposure to apoptotic cells. The interaction of RAW 264...
  6. Liu Y, Michalopoulos G, Zarnegar R. Structural and functional characterization of the mouse hepatocyte growth factor gene promoter. J Biol Chem. 1994;269:4152-60 pubmed
    To understand the molecular mechanisms underlying the regulation of hepatocyte growth factor (HGF) gene expression and to define the DNA sequences essential for its cell-type specific and inducible expression, we have isolated and ..
  7. Cheng N, Chytil A, Shyr Y, Joly A, Moses H. Transforming growth factor-beta signaling-deficient fibroblasts enhance hepatocyte growth factor signaling in mammary carcinoma cells to promote scattering and invasion. Mol Cancer Res. 2008;6:1521-33 pubmed publisher
    ..in fibroblast-epithelial cell cotransplantation studies in mice, correlating with increased expression of hepatocyte growth factor (HGF)...
  8. Powell E, Mars W, Levitt P. Hepatocyte growth factor/scatter factor is a motogen for interneurons migrating from the ventral to dorsal telencephalon. Neuron. 2001;30:79-89 pubmed
    ..The spatial patterns of migratory interneurons reflect the complementary expression of hepatocyte growth factor/scatter factor (HGF/SF) and its receptor, MET, in the forebrain...
  9. Garcia Ocana A, Vasavada R, Cebrian A, Reddy V, Takane K, López Talavera J, et al. Transgenic overexpression of hepatocyte growth factor in the beta-cell markedly improves islet function and islet transplant outcomes in mice. Diabetes. 2001;50:2752-62 pubmed
    ..We have developed three transgenic models in which growth factors (hepatocyte growth factor [HGF], placental lactogen, or parathyroid hormone-related protein) have been targeted to the beta-cell ..

More Information

Publications90

  1. Dietrich S, Abou Rebyeh F, Brohmann H, Bladt F, Sonnenberg Riethmacher E, Yamaai T, et al. The role of SF/HGF and c-Met in the development of skeletal muscle. Development. 1999;126:1621-9 pubmed
    ..Previous work shows that the formation of migratory precursors requires the c-Met and SF/HGF genes...
  2. Lee Y, Moon C, Lee S, Park H, Seoh J, Cho M, et al. Apoptotic cell instillation after bleomycin attenuates lung injury through hepatocyte growth factor induction. Eur Respir J. 2012;40:424-35 pubmed publisher
    Apoptotic cell clearance by macrophages and neighbouring tissue cells induces hepatocyte growth factor (HGF) secretion. HGF plays a key role in alveolar epithelial regeneration and reconstruction after lung injury...
  3. Yang X, Vogan K, Gros P, Park M. Expression of the met receptor tyrosine kinase in muscle progenitor cells in somites and limbs is absent in Splotch mice. Development. 1996;122:2163-71 pubmed
    b>Hepatocyte growth factor/scatter factor (HGF/SF) stimulates proliferation, dissociation, migration and morphogenesis of cells in culture...
  4. Sonnenberg E, Meyer D, Weidner K, Birchmeier C. Scatter factor/hepatocyte growth factor and its receptor, the c-met tyrosine kinase, can mediate a signal exchange between mesenchyme and epithelia during mouse development. J Cell Biol. 1993;123:223-35 pubmed
    Scatter factor/hepatocyte growth factor (SF/HGF) has potent motogenic, mitogenic, and morphogenetic activities on epithelial cells in vitro...
  5. Yamamoto H, Yun E, Gerber H, Ferrara N, Whitsett J, Vu T. Epithelial-vascular cross talk mediated by VEGF-A and HGF signaling directs primary septae formation during distal lung morphogenesis. Dev Biol. 2007;308:44-53 pubmed
    ..for distal lung morphogenesis, coupled with suppression of epithelial cell proliferation and decreased hepatocyte growth factor (Hgf) expression...
  6. Rong S, Segal S, Anver M, Resau J, Vande Woude G. Invasiveness and metastasis of NIH 3T3 cells induced by Met-hepatocyte growth factor/scatter factor autocrine stimulation. Proc Natl Acad Sci U S A. 1994;91:4731-5 pubmed
    The met protooncogene product, Met, is the tyrosine kinase growth factor receptor for hepatocyte growth factor/scatter factor (HGF/SF)...
  7. Jin J, Goldschneider I, Lai L. In vivo administration of the recombinant IL-7/hepatocyte growth factor ? hybrid cytokine efficiently restores thymopoiesis and naive T cell generation in lethally irradiated mice after syngeneic bone marrow transplantation. J Immunol. 2011;186:1915-22 pubmed publisher
    ..We have identified a novel hybrid cytokine containing IL-7 and the ?-chain of hepatocyte growth factor (HGF) in the supernatant of cultured mouse BM stromal cells...
  8. Phaneuf D, Moscioni A, Leclair C, Raper S, Wilson J. Generation of a mouse expressing a conditional knockout of the hepatocyte growth factor gene: demonstration of impaired liver regeneration. DNA Cell Biol. 2004;23:592-603 pubmed
    Hepatocyte growth/scatter factor (HGF/SF) is a pleiotropic cytokine originally identified as a potent mitogen for rat hepatocytes...
  9. Demirci C, Ernst S, Alvarez Perez J, Rosa T, Valle S, Shridhar V, et al. Loss of HGF/c-Met signaling in pancreatic ?-cells leads to incomplete maternal ?-cell adaptation and gestational diabetes mellitus. Diabetes. 2012;61:1143-52 pubmed publisher
    b>Hepatocyte growth factor (HGF) is a mitogen and insulinotropic agent for the ?-cell. However, whether HGF/c-Met has a role in maternal ?-cell adaptation during pregnancy is unknown...
  10. Sisson T, Nguyen M, Yu B, Novak M, Simon R, Koh T. Urokinase-type plasminogen activator increases hepatocyte growth factor activity required for skeletal muscle regeneration. Blood. 2009;114:5052-61 pubmed publisher
    ..hypothesized that urokinase-type plasminogen activator (uPA) promotes muscle regeneration by activating hepatocyte growth factor (HGF), which, in turn, stimulates proliferation of myoblasts required for regeneration...
  11. Takayama H, La Rochelle W, Anver M, Bockman D, Merlino G. Scatter factor/hepatocyte growth factor as a regulator of skeletal muscle and neural crest development. Proc Natl Acad Sci U S A. 1996;93:5866-71 pubmed
    ..Scatter factor/hepatocyte growth factor (SF/HGF) can stimulate motogenic and morphogenetic activities in cultured epithelial cells expressing the ..
  12. Coudriet G, He J, Trucco M, Mars W, Piganelli J. Hepatocyte growth factor modulates interleukin-6 production in bone marrow derived macrophages: implications for inflammatory mediated diseases. PLoS ONE. 2010;5:e15384 pubmed publisher
    ..b>Hepatocyte growth factor (HGF) is transcribed in response to IL-6...
  13. Takayama H, LaRochelle W, Sharp R, Otsuka T, Kriebel P, Anver M, et al. Diverse tumorigenesis associated with aberrant development in mice overexpressing hepatocyte growth factor/scatter factor. Proc Natl Acad Sci U S A. 1997;94:701-6 pubmed
    b>Hepatocyte growth factor/scatter factor (HGF/SF) is a mesenchymally derived, multifunctional paracrine regulator possessing mitogenic, motogenic, and morphogenetic activities in cultured epithelial cells containing its tyrosine kinase ..
  14. Uehara Y, Minowa O, Mori C, Shiota K, Kuno J, Noda T, et al. Placental defect and embryonic lethality in mice lacking hepatocyte growth factor/scatter factor. Nature. 1995;373:702-5 pubmed
    b>Hepatocyte growth factor/scatter factor (HGF/SF) functions as a mitogen, motogen and morphogen for a variety of cultured cells...
  15. Bladt F, Riethmacher D, Isenmann S, Aguzzi A, Birchmeier C. Essential role for the c-met receptor in the migration of myogenic precursor cells into the limb bud. Nature. 1995;376:768-71 pubmed
    ..The specific ligand of the c-met protein, the motility and growth factor scatter factor/hepatocyte growth factor, is expressed in limb mesenchyme and can thus provide the signal for migration which is received by c-met...
  16. Chang C, Chiu J, Chen S, Huang H, Chiu H, Lin B, et al. Activation of HGF/c-Met signaling by ultrafine carbon particles and its contribution to alveolar type II cell proliferation. Am J Physiol Lung Cell Mol Physiol. 2012;302:L755-63 pubmed publisher
    b>Hepatocyte growth factor (HGF) is a potent mitogen and motogen for various epithelial cells...
  17. Araújo T, Oliveira A, Carvalho B, Guadagnini D, Protzek A, Carvalheira J, et al. Hepatocyte growth factor plays a key role in insulin resistance-associated compensatory mechanisms. Endocrinology. 2012;153:5760-9 pubmed publisher
    ..In this context, looking for candidates to be a circulating factor, we realized that hepatocyte growth factor (HGF) is a strong candidate as a link between insulin resistance and increased mass of islets/..
  18. Schmidt C, Bladt F, Goedecke S, Brinkmann V, Zschiesche W, Sharpe M, et al. Scatter factor/hepatocyte growth factor is essential for liver development. Nature. 1995;373:699-702 pubmed
    ..Scatter factor/hepatocyte growth factor (SF/HGF) is the prototype of an emerging family of growth factors that resemble in their domain structure ..
  19. Thompson J, Dolcet X, Hilton M, Tolcos M, Davies A. HGF promotes survival and growth of maturing sympathetic neurons by PI-3 kinase- and MAP kinase-dependent mechanisms. Mol Cell Neurosci. 2004;27:441-52 pubmed
    b>Hepatocyte growth factor (HGF) is a pleiotrophic factor whose many functions include promoting neuronal survival and growth...
  20. Nakamura T, Sakai K, Nakamura T, Matsumoto K. Hepatocyte growth factor twenty years on: Much more than a growth factor. J Gastroenterol Hepatol. 2011;26 Suppl 1:188-202 pubmed publisher
    ..1980s, the method for the cultivation of mature hepatocytes provided an opportunity for the discovery of hepatocyte growth factor (HGF) as a protein that is structurally and functionally different from other growth factors...
  21. Liu Y, Michalopoulos G, Zarnegar R. Molecular cloning and characterization of cDNA encoding mouse hepatocyte growth factor. Biochim Biophys Acta. 1993;1216:299-303 pubmed
    A cDNA encoding mouse hepatocyte growth factor (HGF) has been cloned and completely sequenced by use of reverse transcriptase-polymerase chain reaction (RT-PCR) and subsequent cloning...
  22. Woolf A, Kolatsi Joannou M, Hardman P, Andermarcher E, Moorby C, Fine L, et al. Roles of hepatocyte growth factor/scatter factor and the met receptor in the early development of the metanephros. J Cell Biol. 1995;128:171-84 pubmed
    Several lines of evidence suggest that hepatocyte growth factor/scatter factor (HGF/SF), a soluble protein secreted by embryo fibroblasts and several fibroblast lines, may elicit morphogenesis in adjacent epithelial cells...
  23. Ponzetto C, Pante G, Prunotto C, Ieraci A, Maina F. Met signaling mutants as tools for developmental studies. Int J Dev Biol. 2000;44:645-53 pubmed
    The Met receptor is widely expressed in embryonic and adult epithelial tissues; its ligand (hepatocyte growth factor/scatter factor, HGF/SF) is expressed in the mesenchymal component of various organs...
  24. Zhang M, Liu X, Zhang Y, Zhao J. Loss of betaarrestin1 and betaarrestin2 contributes to pulmonary hypoplasia and neonatal lethality in mice. Dev Biol. 2010;339:407-17 pubmed publisher
    ..Together, our study demonstrates that betaarrestin1 and betaarrestin2 collaborate in embryonic development processes for epithelial pneumocyte differentiation and lung maturation. ..
  25. Wu H, Levitt P. Prenatal expression of MET receptor tyrosine kinase in the fetal mouse dorsal raphe nuclei and the visceral motor/sensory brainstem. Dev Neurosci. 2013;35:1-16 pubmed publisher
    ..we employed in situ hybridization and immunohistochemistry to map the expression of Met and its ligand, Hgf, through prenatal development of the mouse midbrain and hindbrain...
  26. Sakata H, Takayama H, Sharp R, Rubin J, Merlino G, LaRochelle W. Hepatocyte growth factor/scatter factor overexpression induces growth, abnormal development, and tumor formation in transgenic mouse livers. Cell Growth Differ. 1996;7:1513-23 pubmed
    To investigate the in vivo role of hepatocyte growth factor/scatter factor (HGF/SF) in liver function, we generated transgenic mice using a mouse HGF/SF cDNA under the control of the mouse metallothionein gene promoter and 5'/3' flanking ..
  27. Rosen E, Meromsky L, Setter E, Vinter D, Goldberg I. Purified scatter factor stimulates epithelial and vascular endothelial cell migration. Proc Soc Exp Biol Med. 1990;195:34-43 pubmed
    ..Purification of scatter factor (SF) activity from ras-transformed 3T3 cells was reported recently...
  28. Smith A, Oude Elferink R. Liver gene disruptions: winners by KO?. J Hepatol. 1999;31:752-9 pubmed
  29. Cai L, Johnstone B, Cook T, Liang Z, Traktuev D, Cornetta K, et al. Suppression of hepatocyte growth factor production impairs the ability of adipose-derived stem cells to promote ischemic tissue revascularization. Stem Cells. 2007;25:3234-43 pubmed
    ..by ASCs in peripheral ischemia models and have shown that ASCs secrete physiologically relevant levels of hepatocyte growth factor (HGF) and vascular endothelial growth factor...
  30. Landsberg J, Gaffal E, Cron M, Kohlmeyer J, Renn M, Tüting T. Autochthonous primary and metastatic melanomas in Hgf-Cdk4 R24C mice evade T-cell-mediated immune surveillance. Pigment Cell Melanoma Res. 2010;23:649-60 pubmed publisher
    ..Here we report that Hgf-Cdk4(R24C) mice spontaneously develop a spectrum of primary melanomas with high penetrance during their first year ..
  31. Xia J, Dai C, Michalopoulos G, Liu Y. Hepatocyte growth factor attenuates liver fibrosis induced by bile duct ligation. Am J Pathol. 2006;168:1500-12 pubmed
    ..Here we evaluated the therapeutic efficacy of hepatocyte growth factor (HGF) on liver fibrosis induced by bile duct ligation (BDL) and investigated potential mechanisms...
  32. Singhal E, Kumar P, Sen P. A novel role for Bruton's tyrosine kinase in hepatocyte growth factor-mediated immunoregulation of dendritic cells. J Biol Chem. 2011;286:32054-63 pubmed publisher
    The limited success of dendritic cell (DC)-based immunotherapy in multiple myeloma is partly due to hepatocyte growth factor (HGF)-induced DC dysfunction...
  33. Mic F, Duester G. Patterning of forelimb bud myogenic precursor cells requires retinoic acid signaling initiated by Raldh2. Dev Biol. 2003;264:191-201 pubmed
    ..Myogenic precursor cell migration is dependent on limb bud mesenchymal expression of hepatocyte growth factor/scatter factor (Hgf), which encodes a secreted ligand that signals to dermomyotome through the membrane ..
  34. Ikari T, Hiraki A, Seki K, Sugiura T, Matsumoto K, Shirasuna K. Involvement of hepatocyte growth factor in branching morphogenesis of murine salivary gland. Dev Dyn. 2003;228:173-84 pubmed
    We investigated the involvement of hepatocyte growth factor (HGF) in salivary gland (SG) branching morphogenesis. The mouse submandibular gland (SMG) starts to develop at embryonic day 11.5-12 (E11...
  35. Yoshida S, Yamaguchi Y, Itami S, Yoshikawa K, Tabata Y, Matsumoto K, et al. Neutralization of hepatocyte growth factor leads to retarded cutaneous wound healing associated with decreased neovascularization and granulation tissue formation. J Invest Dermatol. 2003;120:335-43 pubmed
    To elucidate biologic functions of hepatocyte growth factor and the c-Met receptor in cutaneous wound healing, we analyzed expression and localization of hepatocyte growth factor and c-Met receptor and used a strategy to neutralize ..
  36. Sugiyama D, Kulkeaw K, Mizuochi C. TGF-beta-1 up-regulates extra-cellular matrix production in mouse hepatoblasts. Mech Dev. 2013;130:195-206 pubmed publisher
    ..Taken together, our observations suggest that hepatoblasts predominantly produce ECM factors under control of TGF-beta-1 in fetal liver. ..
  37. Gui Y, Yeganeh M, Ramanathan S, Leblanc C, Pomerleau V, Ferbeyre G, et al. SOCS1 controls liver regeneration by regulating HGF signaling in hepatocytes. J Hepatol. 2011;55:1300-8 pubmed publisher
    ..We examined the activation of signaling molecules downstream of IL-6 and hepatocyte growth factor (HGF) receptors in the regenerating liver, primary hepatocytes, and in human hepatoma cells...
  38. Tsubaki M, Yamazoe Y, Yanae M, Satou T, Itoh T, Kaneko J, et al. Blockade of the Ras/MEK/ERK and Ras/PI3K/Akt pathways by statins reduces the expression of bFGF, HGF, and TGF-? as angiogenic factors in mouse osteosarcoma. Cytokine. 2011;54:100-7 pubmed publisher
    ..the expression of vascular endothelial growth factor (VEGF), basic fibroblast growth factor (bFGF), hepatocyte growth factor (HGF), and transforming growth factor-? (TGF-?) mRNA in the mouse osteosarcoma cell line LM8...
  39. Kim M, Froehner S, Adams M, Kim H. ?-Syntrophin is required for the hepatocyte growth factor-induced migration of cultured myoblasts. Exp Cell Res. 2011;317:2914-24 pubmed publisher
    ..b>Hepatocyte growth factor (HGF) stimulates migration and lamellipodia formation in cultured C2 myoblasts...
  40. Li Y, Yu J, Li M, Qu Z, Ruan Q. Mouse mesenchymal stem cells from bone marrow differentiate into smooth muscle cells by induction of plaque-derived smooth muscle cells. Life Sci. 2011;88:130-40 pubmed publisher
    ..In vivo efficacy of BMSCs was investigated. After being cultured using SMC-CM, hepatocyte growth factor (HGF) was abundantly secreted into the medium by BMSCs with time...
  41. Liu Y, Beedle A, Lin L, Bell A, Zarnegar R. Identification of a cell-type-specific transcriptional repressor in the promoter region of the mouse hepatocyte growth factor gene. Mol Cell Biol. 1994;14:7046-58 pubmed
    b>Hepatocyte growth factor (HGF), a cytokine with multiple functions, exhibits cell-type-specific as well as cytokine- and steroid hormone-regulated expression...
  42. Matsuoka H, Sisson T, Nishiuma T, Simon R. Plasminogen-mediated activation and release of hepatocyte growth factor from extracellular matrix. Am J Respir Cell Mol Biol. 2006;35:705-13 pubmed
    ..To explore other mechanisms, we considered interactions between the plasminogen activation system and hepatocyte growth factor (HGF)...
  43. Matsumura A, Kubota T, Taiyoh H, Fujiwara H, Okamoto K, Ichikawa D, et al. HGF regulates VEGF expression via the c-Met receptor downstream pathways, PI3K/Akt, MAPK and STAT3, in CT26 murine cells. Int J Oncol. 2013;42:535-42 pubmed publisher
    In the present study, we assessed the involvement of hepatocyte growth factor (HGF)/c-Met signalling with vascular endothelial cell growth factor (VEGF) and hypoxia inducible factor (HIF)-1? expression in the downstream pathways ..
  44. Jindo T, Tsuboi R, Takamori K, Ogawa H. Local injection of hepatocyte growth factor/scatter factor (HGF/SF) alters cyclic growth of murine hair follicles. J Invest Dermatol. 1998;110:338-42 pubmed
    b>Hepatocyte growth factor/scatter factor (HGF/SF) has recently been shown to stimulate the hair follicle growth of mouse vibrissae in vitro...
  45. Patel Y, Kim H, Rappolee D. A role for hepatocyte growth factor during early postimplantation growth of the placental lineage in mice. Biol Reprod. 2000;62:904-12 pubmed
    b>Hepatocyte growth factor (HGF) is implicated in placental development; hgfr and hgf null mutant embryos develop placental insufficiency and lethality at 11.5 days (E11.5) after fertilization...
  46. Di Cicco A, Petit V, Chiche A, Bresson L, Romagnoli M, Orian Rousseau V, et al. Paracrine Met signaling triggers epithelial-mesenchymal transition in mammary luminal progenitors, affecting their fate. elife. 2015;4: pubmed publisher
    b>HGF/Met signaling has recently been associated with basal-type breast cancers, which are thought to originate from progenitor cells residing in the luminal compartment of the mammary epithelium...
  47. Eagleson K, Lane C, McFadyen Ketchum L, Solak S, Wu H, Levitt P. Distinct intracellular signaling mediates C-MET regulation of dendritic growth and synaptogenesis. Dev Neurobiol. 2016;76:1160-81 pubmed publisher
    b>Hepatocyte growth factor (HGF) activation of the MET receptor tyrosine kinase influences multiple neurodevelopmental processes...
  48. Gentile A, D Alessandro L, Lazzari L, Martinoglio B, Bertotti A, Mira A, et al. Met-driven invasive growth involves transcriptional regulation of Arhgap12. Oncogene. 2008;27:5590-8 pubmed publisher
    Invasive growth is a complex biological program triggered by hepatocyte growth factor (HGF) through its tyrosine kinase receptor encoded by the Met proto-oncogene...
  49. Komada M, Soriano P. Hrs, a FYVE finger protein localized to early endosomes, is implicated in vesicular traffic and required for ventral folding morphogenesis. Genes Dev. 1999;13:1475-85 pubmed
    ..The vesicular localization of Hrs was disrupted in cells treated with wortmannin, implicating Hrs in the phosphatidylinositol 3-kinase pathway of membrane trafficking. ..
  50. Ricci G, Catizone A, Galdieri M. Pleiotropic activity of hepatocyte growth factor during embryonic mouse testis development. Mech Dev. 2002;118:19-28 pubmed
    The hepatocyte growth factor (HGF) is a pleiotropic cytokine whose action is mediated by c-met, a glycoproteic receptor with tyrosine kinase activity which transduces its multiple biological activities including cell proliferation, ..
  51. Okano J, Shiota G, Kawasaki H. Protective action of hepatocyte growth factor for acute liver injury caused by D-galactosamine in transgenic mice. Hepatology. 1997;26:1241-9 pubmed
    b>Hepatocyte growth factor (HGF) has been reported to be a potent mitogen for hepatocytes in vivo and in vitro...
  52. Wang X, Zhou Y, Kim H, Song R, Zarnegar R, Ryter S, et al. Hepatocyte growth factor protects against hypoxia/reoxygenation-induced apoptosis in endothelial cells. J Biol Chem. 2004;279:5237-43 pubmed
    ..b>Hepatocyte growth factor markedly inhibited hypoxia/reoxygenation-induced endothelial cell apoptosis...
  53. Niedermaier M, Schwabe G, Fees S, Helmrich A, Brieske N, Seemann P, et al. An inversion involving the mouse Shh locus results in brachydactyly through dysregulation of Shh expression. J Clin Invest. 2005;115:900-9 pubmed
    ..This results in shortening of the digits through an arrest of chondrocyte differentiation and the disruption of joint development. ..
  54. Knowles L, Stabile L, Egloff A, Rothstein M, Thomas S, Gubish C, et al. HGF and c-Met participate in paracrine tumorigenic pathways in head and neck squamous cell cancer. Clin Cancer Res. 2009;15:3740-50 pubmed publisher
    We determined hepatocyte growth factor (HGF) and c-Met expression and signaling in human head and neck squamous cell carcinoma (HNSCC) cells and primary tissues and tested the ability of c-Met tyrosine kinase inhibitors (TKI) to block HGF-..
  55. Giacobini P, Messina A, Wray S, Giampietro C, Crepaldi T, Carmeliet P, et al. Hepatocyte growth factor acts as a motogen and guidance signal for gonadotropin hormone-releasing hormone-1 neuronal migration. J Neurosci. 2007;27:431-45 pubmed
    ..Gradients of secreted molecules may play a role in this migratory process. In this context, hepatocyte growth factor (HGF) is a potential candidate, because it promotes cell motility in developing brain and has been shown ..
  56. Ding B, Nolan D, Butler J, James D, Babazadeh A, Rosenwaks Z, et al. Inductive angiocrine signals from sinusoidal endothelium are required for liver regeneration. Nature. 2010;468:310-5 pubmed publisher
    ..liver regeneration, owing to diminished expression of LSEC-derived angiocrine factors, including hepatocyte growth factor (HGF) and Wnt2...
  57. Lyon M, Deakin J, Rahmoune H, Fernig D, Nakamura T, Gallagher J. Hepatocyte growth factor/scatter factor binds with high affinity to dermatan sulfate. J Biol Chem. 1998;273:271-8 pubmed
    We have demonstrated by affinity chromatography that hepatocyte growth factor/scatter factor (HGF/SF) binds strongly to dermatan sulfate (DS), with a similar ionic strength dependence to that previously seen with heparan sulfate (HS)...
  58. Usatyuk P, Fu P, Mohan V, Epshtein Y, Jacobson J, Gomez Cambronero J, et al. Role of c-Met/phosphatidylinositol 3-kinase (PI3k)/Akt signaling in hepatocyte growth factor (HGF)-mediated lamellipodia formation, reactive oxygen species (ROS) generation, and motility of lung endothelial cells. J Biol Chem. 2014;289:13476-91 pubmed publisher
    b>Hepatocyte growth factor (HGF) mediated signaling promotes cell proliferation and migration in a variety of cell types and plays a key role in tumorigenesis...
  59. Liu Z, Yu C, Nickel C, Thomas S, Cantley L. Hepatocyte growth factor induces ERK-dependent paxillin phosphorylation and regulates paxillin-focal adhesion kinase association. J Biol Chem. 2002;277:10452-8 pubmed
    b>Hepatocyte growth factor (HGF) modulates cell adhesion, migration, and branching morphogenesis in cultured epithelial cells, events that require regulation of cell-matrix interactions...
  60. Proto J, Tang Y, Lu A, Chen W, Stahl E, Poddar M, et al. NF-κB inhibition reveals a novel role for HGF during skeletal muscle repair. Cell Death Dis. 2015;6:e1730 pubmed publisher
    ..In this investigation, we found that the therapeutic effect of NF-κB blockade requires hepatocyte growth factor (HGF) production by myogenic cells...
  61. Li J, Reed S, Johnson S. Hepatocyte growth factor (HGF) signals through SHP2 to regulate primary mouse myoblast proliferation. Exp Cell Res. 2009;315:2284-92 pubmed publisher
    Niche localized HGF plays an integral role in G(0) exit and the return to mitotic activity of adult skeletal muscle satellite cells...
  62. Kalinichenko V, Gusarova G, Kim I, Shin B, Yoder H, Clark J, et al. Foxf1 haploinsufficiency reduces Notch-2 signaling during mouse lung development. Am J Physiol Lung Cell Mol Physiol. 2004;286:L521-30 pubmed
    ..Embryonic Foxf1(+/-) lungs exhibited diminished expression of hepatocyte growth factor receptor c-Met, myosin VI, the transcription factors SP-3, BMI-1, ATF-2, and glucocorticoid receptor, and ..
  63. Gatti S, Leo C, Gallo S, Sala V, Bucci E, Natale M, et al. Gene expression profiling of HGF/Met activation in neonatal mouse heart. Transgenic Res. 2013;22:579-93 pubmed publisher
    b>Hepatocyte Growth Factor (HGF) controls growth and differentiation in different cell types, including cardiac cells. However, its downstream effectors are poorly understood...
  64. Basilico C, Hultberg A, Blanchetot C, De Jonge N, Festjens E, Hanssens V, et al. Four individually druggable MET hotspots mediate HGF-driven tumor progression. J Clin Invest. 2014;124:3172-86 pubmed publisher
    Activation of MET by HGF plays a key role in tumor progression. Using a recently developed llama platform that generates human-like immunoglobulins, we selected 68 different antibodies that compete with HGF for binding to MET...
  65. Jung W, Castren E, Odenthal M, Vande Woude G, Ishii T, Dienes H, et al. Expression and functional interaction of hepatocyte growth factor-scatter factor and its receptor c-met in mammalian brain. J Cell Biol. 1994;126:485-94 pubmed
    b>Hepatocyte growth factor-scatter factor (HGF-SF) is a pleiotropic cytokine with mito-, morpho-, and motogenic effects on a variety of epithelial and endothelial cells...
  66. Kolterud A, Wandzioch E, Carlsson L. Lhx2 is expressed in the septum transversum mesenchyme that becomes an integral part of the liver and the formation of these cells is independent of functional Lhx2. Gene Expr Patterns. 2004;4:521-8 pubmed
    ..5, cells expressing the mutant Lhx2 allel are present in Lhx2(-/-) livers, and expression of Hlx, hepatocyte growth factor, Hex and Prox1, genes known to be important in liver development, is independent of functional Lhx2 ..
  67. Kucia M, Wojakowski W, Reca R, Machalinski B, Gozdzik J, Majka M, et al. The migration of bone marrow-derived non-hematopoietic tissue-committed stem cells is regulated in an SDF-1-, HGF-, and LIF-dependent manner. Arch Immunol Ther Exp (Warsz). 2006;54:121-35 pubmed
    ..In this study we evaluated whether TCSCs respond to other motomorphogens, such as hepatocyte growth factor (HGF) and leukemia inhibitory factor (LIF)...
  68. Thewke D, Seeds N. Expression of hepatocyte growth factor/scatter factor, its receptor, c-met, and tissue-type plasminogen activator during development of the murine olfactory system. J Neurosci. 1996;16:6933-44 pubmed
    The expression of hepatocyte growth factor/scatter factor (HGF/SF) and its receptor, the c-met proto-oncogene product, was examined by in situ hybridization in the developing and adult murine olfactory system and compared with the ..
  69. Li Z, Mizuno S, Nakamura T. Antinecrotic and antiapoptotic effects of hepatocyte growth factor on cholestatic hepatitis in a mouse model of bile-obstructive diseases. Am J Physiol Gastrointest Liver Physiol. 2007;292:G639-46 pubmed
    ..b>Hepatocyte growth factor (HGF) is mitogenic toward hepatocytes, but it is still unclear whether HGF has physiological and ..
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    ..or CXCR4-blocking antibody, but could be reduced by addition of c-met-blocking antibody and augmented by hepatocyte growth factor (HGF), the putative ligand for c-met...
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    b>Hepatocyte growth factor (HGF) inhibits liver fibrosis induced by carbon tetrachloride (CCl4) in animal models. NK2 is a natural splice variant of HGF, but its in vivo function remains to be elucidated...
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    ..While OSM expression in the liver starts in mid gestation and decreases in postnatal stages, hepatocyte growth factor (HGF) is mainly expressed in the liver in the first few days after birth...
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    ..lentiviral-delivered shRNA to generate a clonal line of 3T3-F442A preadipocytes with stable silencing of hepatocyte growth factor (HGF) expression and examined the long-term consequence of this modification on fat pad development...
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    b>Hepatocyte growth factor (HGF) is essential for embryogenesis, tissue regeneration and tumour malignancy through the activation of its receptor, c-Met...
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    ..of genes, as well as noncoding genes, and found three mutations clustered in intron 4 and exon 5 in the hepatocyte growth factor gene (HGF)...