Gene Symbol: Hes7
Description: hes family bHLH transcription factor 7
Alias: bHLHb37, transcription factor HES-7, bHLH factor Hes7, hairy and enhancer of split 7, mHes7
Species: mouse
Products:     Hes7

Top Publications

  1. Wright D, Ferjentsik Z, Chong S, Qiu X, Yun Jin J, Malapert P, et al. Cyclic Nrarp mRNA expression is regulated by the somitic oscillator but Nrarp protein levels do not oscillate. Dev Dyn. 2009;238:3043-3055 pubmed publisher
    ..Despite oscillating mRNA levels, Nrarp protein does not oscillate in the PSM. Finally, neither gain nor loss of Nrarp function interferes with the normal expression of Notch-related cyclic genes. ..
  2. Bessho Y, Miyoshi G, Sakata R, Kageyama R. Hes7: a bHLH-type repressor gene regulated by Notch and expressed in the presomitic mesoderm. Genes Cells. 2001;6:175-85 pubmed
    ..We identified a novel bHLH gene, designated Hes7, from mouse embryos...
  3. Oginuma M, Takahashi Y, Kitajima S, Kiso M, Kanno J, Kimura A, et al. The oscillation of Notch activation, but not its boundary, is required for somite border formation and rostral-caudal patterning within a somite. Development. 2010;137:1515-22 pubmed publisher
    ..This indicates that the initial somite pattern can be defined as a direct output of the segmentation clock...
  4. Takashima Y, Ohtsuka T, Gonzalez A, Miyachi H, Kageyama R. Intronic delay is essential for oscillatory expression in the segmentation clock. Proc Natl Acad Sci U S A. 2011;108:3300-5 pubmed publisher
    ..The basic helix-loop-helix repressor gene Hes7 is cyclically expressed in the presomitic mesoderm (PSM) and regulates the somite segmentation...
  5. Dunty W, Biris K, Chalamalasetty R, Taketo M, Lewandoski M, Yamaguchi T. Wnt3a/beta-catenin signaling controls posterior body development by coordinating mesoderm formation and segmentation. Development. 2008;135:85-94 pubmed
    ..Thus, Wnt3a regulates somitogenesis by activating a network of interacting target genes that promote mesodermal fates, activate the segmentation clock, and position boundary determination genes in the anterior PSM. ..
  6. Morimoto M, Takahashi Y, Endo M, Saga Y. The Mesp2 transcription factor establishes segmental borders by suppressing Notch activity. Nature. 2005;435:354-9 pubmed
    ..We propose that the oscillation of Notch activity is arrested and translated in the wavefront by Mesp2. ..
  7. Dale J, Malapert P, Chal J, Vilhais Neto G, Maroto M, Johnson T, et al. Oscillations of the snail genes in the presomitic mesoderm coordinate segmental patterning and morphogenesis in vertebrate somitogenesis. Dev Cell. 2006;10:355-66 pubmed
    ..Thus, Snail genes define a class of cyclic genes that coordinate segmentation and PSM morphogenesis. ..
  8. Ferjentsik Z, Hayashi S, Dale J, Bessho Y, Herreman A, De Strooper B, et al. Notch is a critical component of the mouse somitogenesis oscillator and is essential for the formation of the somites. PLoS Genet. 2009;5:e1000662 pubmed publisher
    ..analysing embryos carrying a mutation in different components of the Notch pathway, such as Lunatic fringe (Lfng), Hes7, Rbpj, and presenilin1/presenilin2 (Psen1/Psen2), and by pharmacological blocking of the Notch pathway...
  9. Harima Y, Takashima Y, Ueda Y, Ohtsuka T, Kageyama R. Accelerating the tempo of the segmentation clock by reducing the number of introns in the Hes7 gene. Cell Rep. 2013;3:1-7 pubmed publisher
    Periodic somite segmentation is controlled by the cyclic gene Hes7, whose oscillatory expression depends upon negative feedback with a delayed timing...

More Information


  1. Ishikawa A, Kitajima S, Takahashi Y, Kokubo H, Kanno J, Inoue T, et al. Mouse Nkd1, a Wnt antagonist, exhibits oscillatory gene expression in the PSM under the control of Notch signaling. Mech Dev. 2004;121:1443-53 pubmed
    ..whereas nkd1 oscillations have a similar phase to lunatic fringe (L-fng) transcription and they are arrested in Hes7 (a negative regulator of Notch signaling) deficient embryos...
  2. Serth K, Schuster Gossler K, Cordes R, Gossler A. Transcriptional oscillation of lunatic fringe is essential for somitogenesis. Genes Dev. 2003;17:912-25 pubmed
    ..Similarly, dynamic expression of Hes7 was not abolished but abnormal expression patterns were obtained...
  3. Chen J, Kang L, Zhang N. Negative feedback loop formed by Lunatic fringe and Hes7 controls their oscillatory expression during somitogenesis. Genesis. 2005;43:196-204 pubmed
    ..We also show that Hes7, another cyclically expressed protein, can bind to the N-boxes on both Lfng and its own promoters and repress their ..
  4. Niwa Y, Masamizu Y, Liu T, Nakayama R, Deng C, Kageyama R. The initiation and propagation of Hes7 oscillation are cooperatively regulated by Fgf and notch signaling in the somite segmentation clock. Dev Cell. 2007;13:298-304 pubmed
    Periodic formation of somites is controlled by the segmentation clock, where the oscillator Hes7 regulates cyclic expression of the Notch modulator Lunatic fringe...
  5. Hirata H, Bessho Y, Kokubu H, Masamizu Y, Yamada S, Lewis J, et al. Instability of Hes7 protein is crucial for the somite segmentation clock. Nat Genet. 2004;36:750-4 pubmed
    ..Expression of the basic helix-loop-helix factor Hes7, an effector of Notch signaling, follows a 2-hour oscillatory cycle controlled by negative feedback; this is ..
  6. Shifley E, Vanhorn K, Perez Balaguer A, Franklin J, Weinstein M, Cole S. Oscillatory lunatic fringe activity is crucial for segmentation of the anterior but not posterior skeleton. Development. 2008;135:899-908 pubmed publisher
  7. Hoyle N, Ish Horowicz D. Transcript processing and export kinetics are rate-limiting steps in expressing vertebrate segmentation clock genes. Proc Natl Acad Sci U S A. 2013;110:E4316-24 pubmed publisher
    ..Here, we measure expression delays for three transcripts [Lunatic fringe, Hes7/her1, and Notch-regulated-ankyrin-repeat-protein (Nrarp)], that cycle during segmentation in the zebrafish, chick, ..
  8. Hayashi S, Shimoda T, Nakajima M, Tsukada Y, Sakumura Y, Dale J, et al. Sprouty4, an FGF inhibitor, displays cyclic gene expression under the control of the notch segmentation clock in the mouse PSM. PLoS ONE. 2009;4:e5603 pubmed publisher
    ..Sprouty4 does not oscillate in Hes7-null mutant mouse embryos, and Hes7 can inhibit FGF-induced transcriptional activity of the Sprouty4 promoter...
  9. Kim W, Matsui T, Yamao M, Ishibashi M, Tamada K, Takumi T, et al. The period of the somite segmentation clock is sensitive to Notch activity. Mol Biol Cell. 2011;22:3541-9 pubmed publisher
    ..Therefore we propose that the period of the somite segmentation clock is sensitive to Notch activity and that Nrarp plays essential roles in the morphology of vertebrae and ribs. ..
  10. Feller J, Schneider A, Schuster Gossler K, Gossler A. Noncyclic Notch activity in the presomitic mesoderm demonstrates uncoupling of somite compartmentalization and boundary formation. Genes Dev. 2008;22:2166-71 pubmed publisher
    ..Embryos expressing NICD formed up to 18 somites. Expression in the PSM of Hes7, Lfng, and Spry2 was no longer cyclic, whereas Axin2 was expressed dynamically...
  11. Nitanda Y, Matsui T, Matta T, Higami A, Kohno K, Nakahata Y, et al. 3'-UTR-dependent regulation of mRNA turnover is critical for differential distribution patterns of cyclic gene mRNAs. FEBS J. 2014;281:146-56 pubmed publisher
    ..periodic event in the development of vertebrates, is instructed by cyclic expression of several genes, including Hes7 and Lunatic fringe (Lfng). Transcriptional regulation accounts for the cyclic expression...
  12. Bessho Y, Sakata R, Komatsu S, Shiota K, Yamada S, Kageyama R. Dynamic expression and essential functions of Hes7 in somite segmentation. Genes Dev. 2001;15:2642-7 pubmed
    The basic helix-loop-helix (bHLH) gene Hes7, a putative Notch effector, encodes a transcriptional repressor. Here, we found that Hes7 expression oscillates in 2-h cycles in the presomitic mesoderm (PSM)...
  13. Aulehla A, Wiegraebe W, Baubet V, Wahl M, Deng C, Taketo M, et al. A beta-catenin gradient links the clock and wavefront systems in mouse embryo segmentation. Nat Cell Biol. 2008;10:186-93 pubmed
    ..This gradient of nuclear beta-catenin defines the size of the oscillatory field and controls key aspects of PSM maturation and segment formation, emphasizing the central role of Wnt signalling in this process. ..
  14. Stauber M, Laclef C, Vezzaro A, Page M, Ish Horowicz D. Modifying transcript lengths of cycling mouse segmentation genes. Mech Dev. 2012;129:61-72 pubmed publisher
    ..Mutants in several oscillating genes including the Notch pathway gene Lunatic fringe (Lfng) and the Notch target Hes7, result in defective somitogenesis and disorganised axial skeletons...
  15. Vermot J, Gallego Llamas J, Fraulob V, Niederreither K, Chambon P, Dolle P. Retinoic acid controls the bilateral symmetry of somite formation in the mouse embryo. Science. 2005;308:563-6 pubmed
    ..These data implicate retinoic acid as an endogenous signal that maintains the bilateral synchrony of mesoderm segmentation, and therefore controls bilateral symmetry, in vertebrate embryos. ..
  16. Bessho Y, Hirata H, Masamizu Y, Kageyama R. Periodic repression by the bHLH factor Hes7 is an essential mechanism for the somite segmentation clock. Genes Dev. 2003;17:1451-6 pubmed
    b>Hes7, a bHLH gene essential for somitogenesis, displays cyclic expression of mRNA in the presomitic mesoderm (PSM). Here, we show that Hes7 protein is also expressed in a dynamic manner, which depends on proteasome-mediated degradation...
  17. Girós A, Grgur K, Gossler A, Costell M. ?5?1 integrin-mediated adhesion to fibronectin is required for axis elongation and somitogenesis in mice. PLoS ONE. 2011;6:e22002 pubmed publisher
    ..Thus, ?5?1-mediated adhesion to FN in the PSM regulates the dynamics of membrane protrusions and cell-to-cell communication essential for elongation and segmentation of the body axis. ..
  18. Sparrow D, Guillen Navarro E, Fatkin D, Dunwoodie S. Mutation of Hairy-and-Enhancer-of-Split-7 in humans causes spondylocostal dysostosis. Hum Mol Genet. 2008;17:3761-6 pubmed publisher
    ..used autozygosity mapping to identify a mutation in a fourth Notch pathway gene, Hairy-and-Enhancer-of-Split-7 (HES7), in an autosomal recessive SCD family...
  19. Lopez T, Fan C. Dynamic CREB family activity drives segmentation and posterior polarity specification in mammalian somitogenesis. Proc Natl Acad Sci U S A. 2013;110:E2019-27 pubmed publisher
    ..Together, these data support that the CREB family acts at the determination front to modulate Wnt signaling and strengthen Notch signaling as a means to orchestrate cells for somite segmentation and anterior/posterior patterning. ..
  20. Andersson E, Bryjova L, Biris K, Yamaguchi T, Arenas E, Bryja V. Genetic interaction between Lrp6 and Wnt5a during mouse development. Dev Dyn. 2010;239:237-45 pubmed publisher
    ..Interestingly these results reveal a further level of complexity in processes in which Wnt5a and LRP6 cooperate, or oppose each other, during mouse development. ..
  21. Schröder N, Gossler A. Expression of Notch pathway components in fetal and adult mouse small intestine. Gene Expr Patterns. 2002;2:247-50 pubmed
  22. Lourenço R, Lopes S, Saude L. Left-right function of dmrt2 genes is not conserved between zebrafish and mouse. PLoS ONE. 2010;5:e14438 pubmed publisher
    ..Our results show that the role of dmrt2 gene is not conserved during zebrafish and mouse embryonic development. ..
  23. Young T, Rowland J, van de Ven C, Bialecka M, Novoa A, Carapuco M, et al. Cdx and Hox genes differentially regulate posterior axial growth in mammalian embryos. Dev Cell. 2009;17:516-26 pubmed publisher
    ..Concomitant regulation of Cyp26a1 expression, restraining retinoic acid signaling away from the posterior growth zone, may likewise play a role in timing the trunk-tail transition. ..
  24. Oginuma M, Niwa Y, Chapman D, Saga Y. Mesp2 and Tbx6 cooperatively create periodic patterns coupled with the clock machinery during mouse somitogenesis. Development. 2008;135:2555-62 pubmed publisher
    ..Taken together, we conclude that Mesp2 is the final output signal by which the temporal information from the segmentation clock is translated into segmental patterning during mouse somitogenesis...
  25. Tsunematsu R, Nakayama K, Oike Y, Nishiyama M, Ishida N, Hatakeyama S, et al. Mouse Fbw7/Sel-10/Cdc4 is required for notch degradation during vascular development. J Biol Chem. 2004;279:9417-23 pubmed
    ..Expression of Notch1, -2, or -3 or of cyclin E was unaffected in Fbw7(-/-) embryos. Mammalian Fbw7 thus appears to play an indispensable role in negative regulation of the Notch4-Hey1 pathway and is required for vascular development. ..
  26. Fujimuro T, Matsui T, Nitanda Y, Matta T, Sakumura Y, Saito M, et al. Hes7 3'UTR is required for somite segmentation function. Sci Rep. 2014;4:6462 pubmed publisher
    ..We attempted to elongate the oscillation period by increasing the time to transcribe Hes7 in this research. We generated knock-in mice, in which a large intron was inserted into Hes7 3'UTR...
  27. Zheng X, Zheng X, Wang Y, Wang Y, Yao Q, Yao Q, et al. A genome-wide survey on basic helix-loop-helix transcription factors in rat and mouse. Mamm Genome. 2009;20:236-46 pubmed publisher
    ..The present study provides useful information for future studies using rat as a model animal for mammalian development. ..
  28. Kusumi K, Mimoto M, Covello K, Beddington R, Krumlauf R, Dunwoodie S. Dll3 pudgy mutation differentially disrupts dynamic expression of somite genes. Genesis. 2004;39:115-21 pubmed
    ..In the mouse, notch pathway genes such as Lfng, Hes1, Hes7, and Hey2 display dynamic patterns of expression in paraxial mesoderm, cycling in synchrony with somite formation (..
  29. Gonzalez A, Manosalva I, Liu T, Kageyama R. Control of Hes7 expression by Tbx6, the Wnt pathway and the chemical Gsk3 inhibitor LiCl in the mouse segmentation clock. PLoS ONE. 2013;8:e53323 pubmed publisher
    ..A crucial component of the segmentation clock is the gene Hes7, which is regulated by the Notch and Fgf/Mapk pathways, but its relation to other pathways is unknown...
  30. Niwa Y, Shimojo H, Isomura A, Gonzalez A, Miyachi H, Kageyama R. Different types of oscillations in Notch and Fgf signaling regulate the spatiotemporal periodicity of somitogenesis. Genes Dev. 2011;25:1115-20 pubmed publisher
    ..These results suggest that Notch oscillators define the prospective somite region, while Fgf oscillators regulate the pace of segmentation...
  31. Naiche L, Holder N, Lewandoski M. FGF4 and FGF8 comprise the wavefront activity that controls somitogenesis. Proc Natl Acad Sci U S A. 2011;108:4018-23 pubmed publisher
    ..Furthermore, these data show that FGF action maintains WNT signaling, and that both signaling pathways are required in parallel to maintain PSM progenitor tissue. ..
  32. Ramkumar N, Harvey B, Lee J, Alcorn H, Silva Gagliardi N, McGlade C, et al. Protein O-Glucosyltransferase 1 (POGLUT1) Promotes Mouse Gastrulation through Modification of the Apical Polarity Protein CRUMBS2. PLoS Genet. 2015;11:e1005551 pubmed publisher
  33. Shimojo H, Isomura A, Ohtsuka T, Kori H, Miyachi H, Kageyama R. Oscillatory control of Delta-like1 in cell interactions regulates dynamic gene expression and tissue morphogenesis. Genes Dev. 2016;30:102-16 pubmed publisher
    Notch signaling regulates tissue morphogenesis through cell-cell interactions. The Notch effectors Hes1 and Hes7 are expressed in an oscillatory manner and regulate developmental processes such as neurogenesis and somitogenesis, ..
  34. Raetzman L, Wheeler B, Ross S, Thomas P, Camper S. Persistent expression of Notch2 delays gonadotrope differentiation. Mol Endocrinol. 2006;20:2898-908 pubmed
    ..This demonstrates that activated Notch2 is sufficient to delay gonadotrope differentiation, and it supports the hypothesis that Notch2 regulates progenitor cell differentiation in the pituitary gland. ..
  35. Sugita S, Hosaka Y, Okada K, Mori D, Yano F, Kobayashi H, et al. Transcription factor Hes1 modulates osteoarthritis development in cooperation with calcium/calmodulin-dependent protein kinase 2. Proc Natl Acad Sci U S A. 2015;112:3080-5 pubmed publisher
    ..Our findings have contributed to further understanding of the molecular pathophysiology of OA, and may provide the basis for development of novel treatments for joint disorders. ..
  36. Maruhashi M, Van de Putte T, Huylebroeck D, Kondoh H, Higashi Y. Involvement of SIP1 in positioning of somite boundaries in the mouse embryo. Dev Dyn. 2005;234:332-8 pubmed
    ..This is accompanied by the rostral extension of oscillatory gene expression such as L-fng, Hes7, and Dll1, and the rostrally shifted termination of Raldh2 expression that continues from the anterior embryonic ..
  37. Chen L, Al Awqati Q. Segmental expression of Notch and Hairy genes in nephrogenesis. Am J Physiol Renal Physiol. 2005;288:F939-52 pubmed
    ..These studies provide the basis for the future development of strategies to examine the role of individual effector molecules in the determination of the differentiation pattern of the nephron. ..
  38. Stauber M, Sachidanandan C, Morgenstern C, Ish Horowicz D. Differential axial requirements for lunatic fringe and Hes7 transcription during mouse somitogenesis. PLoS ONE. 2009;4:e7996 pubmed publisher
    ..segments normally in the complete absence of Lfng and shows a reduced requirement for another oscillating gene, Hes7, indicating that the architecture of the clock alters as segmentation progresses...
  39. Warrier S, Nuwayhid S, Sabatino J, Sugrue K, Zohn I. Supt20 is required for development of the axial skeleton. Dev Biol. 2017;421:245-257 pubmed publisher
    ..the prospective rostral somite was reduced accompanied by expansion of caudal somite markers such as EphrinB2 and Hes7. Supt20 interacts with the Gcn5-containing SAGA histone acetylation complex...
  40. Katoh M, Katoh M. Integrative genomic analyses on HES/HEY family: Notch-independent HES1, HES3 transcription in undifferentiated ES cells, and Notch-dependent HES1, HES5, HEY1, HEY2, HEYL transcription in fetal tissues, adult tissues, or cancer. Int J Oncol. 2007;31:461-6 pubmed
    ..bHLH transcription factors with Orange domain were grouped into HES subfamily (HES1, HES2, HES3, HES4, HES5, HES6, HES7) and HEY subfamily (HEY1, HEY2, HEYL, HESL/HELT, DEC1/BHLHB2, DEC2/BHLHB3)...
  41. Anderson M, Schimmang T, Lewandoski M. An FGF3-BMP Signaling Axis Regulates Caudal Neural Tube Closure, Neural Crest Specification and Anterior-Posterior Axis Extension. PLoS Genet. 2016;12:e1006018 pubmed publisher
    ..Uncovering this FGF3-BMP signaling axis is a major advance toward understanding how these tissue layers interact during axis extension with important implications in human disease. ..
  42. Schuster Gossler K, Harris B, Johnson K, Serth J, Gossler A. Notch signalling in the paraxial mesoderm is most sensitive to reduced Pofut1 levels during early mouse development. BMC Dev Biol. 2009;9:6 pubmed publisher
    ..Reduced POFUT1 levels might affect Notch trafficking or overall O-fucosylation. Alternatively, reduced O-fucosylation might preferentially affect sites that are substrates for LFNG and thus important for somite formation and patterning. ..
  43. Chalamalasetty R, Dunty W, Biris K, Ajima R, Iacovino M, Beisaw A, et al. The Wnt3a/β-catenin target gene Mesogenin1 controls the segmentation clock by activating a Notch signalling program. Nat Commun. 2011;2:390 pubmed publisher
    ..Msgn1 also indirectly regulates cyclic genes in the Fgf and Wnt pathways. Thus, Msgn1 is a central component of a transcriptional cascade that translates a spatial Wnt3a gradient into a temporal pattern of clock gene expression. ..
  44. Sparrow D, Chapman G, Smith A, Mattar M, Major J, O Reilly V, et al. A mechanism for gene-environment interaction in the etiology of congenital scoliosis. Cell. 2012;149:295-306 pubmed publisher
    ..Our results potentially provide a mechanism for the genesis of a host of common sporadic congenital abnormalities through gene-environment interaction...
  45. Ishii A, Kobayashi T, Kageyama R. Requirement of multiple lysine residues for the transcriptional activity and the instability of Hes7. Biochem Biophys Res Commun. 2008;372:142-6 pubmed publisher
    The basic helix-loop-helix (bHLH) gene Hes7 is expressed in an oscillatory manner and regulates the periodic somite formation...
  46. Sonnen K, Lauschke V, Uraji J, Falk H, Petersen Y, Funk M, et al. Modulation of Phase Shift between Wnt and Notch Signaling Oscillations Controls Mesoderm Segmentation. Cell. 2018;172:1079-1090.e12 pubmed publisher
    ..Our work hence reveals that dynamic signaling, i.e., the relative timing between oscillatory signals, encodes essential information during multicellular development. ..
  47. Anderson K, White P, Kaestner K, Sussel L. Identification of known and novel pancreas genes expressed downstream of Nkx2.2 during development. BMC Dev Biol. 2009;9:65 pubmed publisher
    ..2 in maintaining appropriate exocrine gene expression. Most importantly, Nkx2.2 appears to function within a complex regulatory loop with Ngn3 at a key endocrine differentiation step. ..
  48. Matsumiya M, Tomita T, Yoshioka Kobayashi K, Isomura A, Kageyama R. ES cell-derived presomitic mesoderm-like tissues for analysis of synchronized oscillations in the segmentation clock. Development. 2018;145: pubmed publisher
    ..In the mouse embryo, this periodicity is controlled by the segmentation clock gene Hes7, which exhibits wave-like oscillatory expression in the PSM...
  49. Williams D, Shifley E, Braunreiter K, Cole S. Disruption of somitogenesis by a novel dominant allele of Lfng suggests important roles for protein processing and secretion. Development. 2016;143:822-30 pubmed publisher
    ..Expression of clock-linked genes is perturbed and mature Hes7 transcripts are stabilized in the presomitic mesoderm of mutant mice, suggesting that both transcriptional and post-..
  50. Zeiser S, Rivera O, Kuttler C, Hense B, Lasser R, Winkler G. Oscillations of Hes7 caused by negative autoregulation and ubiquitination. Comput Biol Chem. 2008;32:47-51 pubmed
    Loss of Hes7 function leads to irregular somite formation demonstrating that Hes7 is a crucial component of the segmentation clock during somitogenesis...
  51. Harima Y, Kageyama R. Oscillatory links of Fgf signaling and Hes7 in the segmentation clock. Curr Opin Genet Dev. 2013;23:484-90 pubmed publisher
    Somitogenesis is controlled by the segmentation clock, where the oscillatory expression of cyclic genes such as Hes7 leads to the periodic expression of Mesp2, a master gene for somite formation...
  52. Takahashi J, Ohbayashi A, Oginuma M, Saito D, Mochizuki A, Saga Y, et al. Analysis of Ripply1/2-deficient mouse embryos reveals a mechanism underlying the rostro-caudal patterning within a somite. Dev Biol. 2010;342:134-45 pubmed publisher
    ..We propose that the rostro-caudal pattern is established by dynamic interaction of Notch activity with two Mesp2 domains, which are defined in successive segmentation cycles by Notch, Tbx6 and Ripply1/2...
  53. Biris K, Dunty W, Yamaguchi T. Mouse Ripply2 is downstream of Wnt3a and is dynamically expressed during somitogenesis. Dev Dyn. 2007;236:3167-72 pubmed
    ..Continued expression of Ripply2 in embryos lacking Hes7, a molecular oscillator in the Notch clock, indicates that Hes7 is not a major regulator of Ripply2...
  54. Chen J, Lu L, Shi S, Stanley P. Expression of Notch signaling pathway genes in mouse embryos lacking beta4galactosyltransferase-1. Gene Expr Patterns. 2006;6:376-82 pubmed
    ..01). The subtlety of the in vivo phenotype may be due to redundancy since several B4galt genes related to B4galt1 are expressed during embryogenesis. ..
  55. Casaca A, Nóvoa A, Mallo M. Hoxb6 can interfere with somitogenesis in the posterior embryo through a mechanism independent of its rib-promoting activity. Development. 2016;143:437-48 pubmed publisher
    ..Our results suggest the requirement of precisely regulated Hoxb6 expression for proper segmentation at tailbud stages. ..