Gene Symbol: Hdgfl2
Description: HDGF like 2
Alias: HRP-2, Hdgfrp2, hepatoma-derived growth factor-related protein 2, hepatoma-derived growth factor, related protein 2
Izumoto Y, Kuroda T, Harada H, Kishimoto T, Nakamura H. Hepatoma-derived growth factor belongs to a gene family in mice showing significant homology in the amino terminus. Biochem Biophys Res Commun. 1997;238:26-32 pubmed
..HRP-1 is expressed specifically in testis. These findings suggest that the HDGF gene family might play a new role in the nucleus especially in testis. ..
Wang H, Shun M, Dickson A, ENGELMAN A. Embryonic Lethality Due to Arrested Cardiac Development in Psip1/Hdgfrp2 Double-Deficient Mice. PLoS ONE. 2015;10:e0137797 pubmed publisher
..To learn about the role of HRP2 in development, we knocked out the Hdgfrp2 gene, which encodes for HRP2, in both normal and Psip1 knockout mice...
Wang H, Jurado K, Wu X, Shun M, Li X, Ferris A, et al
. HRP2 determines the efficiency and specificity of HIV-1 integration in LEDGF/p75 knockout cells but does not contribute to the antiviral activity of a potent LEDGF/p75-binding site integrase inhibitor. Nucleic Acids Res. 2012;40:11518-30 pubmed publisher
..To assess the role of HRP2 in HIV-1 integration, cells generated from Hdgfrp2 (the gene that encodes for HRP2) and Psip1/Hdgfrp2 KO mice were infected alongside matched control cells...
Gao K, Xu C, Jin X, Wumaier R, Ma J, Peng J, et al
. HDGF-related protein-2 (HRP-2) acts as an oncogene to promote cell growth in hepatocellular carcinoma. Biochem Biophys Res Commun. 2015;458:849-55 pubmed publisher
b>HDGFRP2 (HRP-2) belongs to the Hepatoma-derived growth factor (HDGF)-related proteins (HRPs) family, which are characterized by a conserved HATH/PWWP domain at a well-conserved region of the N-terminus...
Thakar K, Votteler I, Kelkar D, Shidore T, Gupta S, Kelm S, et al
. Interaction of HRP-2 isoforms with HDGF: chromatin binding of a specific heteromer. FEBS J. 2012;279:737-51 pubmed publisher
..In conclusion, these observations provide a new perspective for understanding the biological functions of HDGF and related proteins. ..