Hdgf

Summary

Gene Symbol: Hdgf
Description: hepatoma-derived growth factor
Alias: AI118077, D3Ertd299e, hepatoma-derived growth factor
Species: mouse
Products:     Hdgf

Top Publications

  1. Izumoto Y, Kuroda T, Harada H, Kishimoto T, Nakamura H. Hepatoma-derived growth factor belongs to a gene family in mice showing significant homology in the amino terminus. Biochem Biophys Res Commun. 1997;238:26-32 pubmed
    Hepatoma-derived growth factor (HDGF) is an acidic polypeptide with mitogenic activity for fibroblasts performed outside the cells despite the presence of a putative nuclear localization signal (NLS)...
  2. Enomoto H, Yoshida K, Kishima Y, Kinoshita T, Yamamoto M, Everett A, et al. Hepatoma-derived growth factor is highly expressed in developing liver and promotes fetal hepatocyte proliferation. Hepatology. 2002;36:1519-27 pubmed
    Hepatoma-derived growth factor (HDGF) is a heparin-binding protein, which has been purified from the conditioned media of HuH-7 hepatoma cells...
  3. Gallitzendoerfer R, Abouzied M, Hartmann D, Dobrowolski R, Gieselmann V, Franken S. Hepatoma-derived growth factor (HDGF) is dispensable for normal mouse development. Dev Dyn. 2008;237:1875-85 pubmed publisher
    Hepatoma-derived growth factor (HDGF) is suggested to be involved in organ development and exhibits proliferative, angiogenic, and neurotrophic activity. The in vivo functions are, however, so far unknown...
  4. Hu T, Huang C, Liu L, Lin P, Liu S, Chang H, et al. Expression of hepatoma-derived growth factor in hepatocellular carcinoma. Cancer. 2003;98:1444-56 pubmed
    Hepatoma-derived growth factor (HDGF) is a novel growth factor derived from a hepatoma cell line. The current study was designed to elucidate the role of HDGF expression during the pathogenesis of hepatocellular carcinoma (HCC)...
  5. Okuda Y, Nakamura H, Yoshida K, Enomoto H, Uyama H, Hirotani T, et al. Hepatoma-derived growth factor induces tumorigenesis in vivo through both direct angiogenic activity and induction of vascular endothelial growth factor. Cancer Sci. 2003;94:1034-41 pubmed
    Hepatoma-derived growth factor (HDGF) is highly expressed in tumor cells, and stimulates their proliferation. In the present study, we investigated the role of HDGF in tumorigenesis and elucidated the mechanism of action...
  6. Kishima Y, Yamamoto H, Izumoto Y, Yoshida K, Enomoto H, Yamamoto M, et al. Hepatoma-derived growth factor stimulates cell growth after translocation to the nucleus by nuclear localization signals. J Biol Chem. 2002;277:10315-22 pubmed
    Hepatoma-derived growth factor (HDGF) is the original member of the HDGF family of proteins, which contains a well-conserved N-terminal amino acid sequence (homologous to the amino terminus of HDGF; hath) and nuclear localization signals (..
  7. Kao Y, Chen C, Jawan B, Chung Y, Sun C, Kuo S, et al. Upregulation of hepatoma-derived growth factor is involved in murine hepatic fibrogenesis. J Hepatol. 2010;52:96-105 pubmed publisher
    Hepatoma-derived growth factor (HDGF) expression is correlated with progression of hepatocellular carcinoma...
  8. Abouzied M, Baader S, Dietz F, Kappler J, Gieselmann V, Franken S. Expression patterns and different subcellular localization of the growth factors HDGF (hepatoma-derived growth factor) and HRP-3 (HDGF-related protein-3) suggest functions in addition to their mitogenic activity. Biochem J. 2004;378:169-76 pubmed
    b>HDGF (hepatoma-derived growth factor) and the HRPs (HDGF-related proteins) comprise a family of six proteins which display high identity in their N-terminus, but differ at the C-terminus...
  9. Zhou Z, Yamamoto Y, Sugai F, Yoshida K, Kishima Y, Sumi H, et al. Hepatoma-derived growth factor is a neurotrophic factor harbored in the nucleus. J Biol Chem. 2004;279:27320-6 pubmed
    Hepatoma-derived growth factor (HDGF) is a heparin-binding proliferating factor originally isolated from conditioned medium of the hepatoma-derived cell line HuH-7...

More Information

Publications19

  1. Tsai H, Wu J, Kung M, Liu L, Kuo L, Kuo H, et al. Up-regulation of hepatoma-derived growth factor facilitates tumor progression in malignant melanoma [corrected]. PLoS ONE. 2013;8:e59345 pubmed publisher
    Cutaneous malignant melanoma is the fastest increasing malignancy in humans. Hepatoma-derived growth factor (HDGF) is a novel growth factor identified from human hepatoma cell line...
  2. Thakar K, Votteler I, Kelkar D, Shidore T, Gupta S, Kelm S, et al. Interaction of HRP-2 isoforms with HDGF: chromatin binding of a specific heteromer. FEBS J. 2012;279:737-51 pubmed publisher
    ..protein 2 (HRP-2) belongs to a family with five additional members: hepatoma-derived growth factor (HDGF); lens epithelium-derived growth factor; and the HDGF-related proteins -1, -3 and -4...
  3. Tou L, Liu Q, Shivdasani R. Regulation of mammalian epithelial differentiation and intestine development by class I histone deacetylases. Mol Cell Biol. 2004;24:3132-9 pubmed
    ..Thus, modulation of endogenous class I HDAC levels represents a previously unappreciated mechanism to enable onset of tissue-restricted gene expression in a developing mammalian organ. ..
  4. Wang C, Davamani F, Sue S, Lee S, Wu P, Tang F, et al. Cell surface heparan sulfates mediate internalization of the PWWP/HATH domain of HDGF via macropinocytosis to fine-tune cell signalling processes involved in fibroblast cell migration. Biochem J. 2011;433:127-38 pubmed publisher
    b>HDGF (hepatoma-derived growth factor) stimulates cell proliferation by functioning on both sides of the plasma membrane as a ligand for membrane receptor binding to trigger cell signalling and as a stimulator for DNA synthesis in the ..
  5. Everett A. Identification, cloning, and developmental expression of hepatoma-derived growth factor in the developing rat heart. Dev Dyn. 2001;222:450-8 pubmed
    b>Hepatoma derived growth factor (HDGF) was identified as a developmentally regulated cardiac gene by mRNA differential display using 12-day rat fetal conotruncus vs. newborn aorta...
  6. Sun A, Li C, Zhang Y, Lin S, Niu H, Shi Y. Hepatocarcinoma cell-derived hepatoma-derived growth factor (HDGF) induces regulatory T cells. Cytokine. 2015;72:31-5 pubmed publisher
    ..This study aims to investigate the role of the hepatoma-derived growth factor (HDGF) in the generation of regulatory T cells (Treg). CCL-9.1 cells (A mouse hepatoma cell line), were cultured...
  7. Zhang T, Yao Y, Wang J, Li Y, He P, Pasupuleti V, et al. Haploinsufficiency of Klippel-Trenaunay syndrome gene Aggf1 inhibits developmental and pathological angiogenesis by inactivating PI3K and AKT and disrupts vascular integrity by activating VE-cadherin. Hum Mol Genet. 2016;25:5094-5110 pubmed publisher
    ..Together with recent identification of somatic mutations in p110? (encoded by PIK3CA), our data establish a potential mechanistic link between AGGF1 and PIK3CA, the two genes identified for KTS. ..
  8. Sedlmaier A, Wernert N, Gallitzendörfer R, Abouzied M, Gieselmann V, Franken S. Overexpression of hepatoma-derived growth factor in melanocytes does not lead to oncogenic transformation. BMC Cancer. 2011;11:457 pubmed publisher
    b>HDGF is a growth factor which is overexpressed in a wide range of tumors. Importantly, expression levels were identified as a prognostic marker in some types of cancer such as melanoma...
  9. Marubuchi S, Okuda T, Tagawa K, Enokido Y, Horiuchi D, Shimokawa R, et al. Hepatoma-derived growth factor, a new trophic factor for motor neurons, is up-regulated in the spinal cord of PQBP-1 transgenic mice before onset of degeneration. J Neurochem. 2006;99:70-83 pubmed
    Hepatoma-derived growth factor (HDGF) is a nuclear protein homologous to the high-mobility group B1 family of proteins. It is known to be released from cells and to act as a trophic factor for dividing cells...
  10. Yang J, Everett A. Hepatoma-derived growth factor represses SET and MYND domain containing 1 gene expression through interaction with C-terminal binding protein. J Mol Biol. 2009;386:938-50 pubmed publisher
    Hepatoma-derived growth factor (HDGF) is a nuclear protein with both mitogenic and angiogenic activity that is highly expressed in the developing heart and vasculature. To date, the mechanism underlying the function of HDGF is unknown...