Gene Symbol: Hdc
Description: histidine decarboxylase
Alias: AW108189, Hdc-a, Hdc-c, Hdc-e, Hdc-s, histidine decarboxylase, L-histidine decarboxylase
Species: mouse
Products:     Hdc

Top Publications

  1. Seike M, Ikeda M, Kodama H, Terui T, Ohtsu H. Inhibition of scratching behaviour caused by contact dermatitis in histidine decarboxylase gene knockout mice. Exp Dermatol. 2005;14:169-75 pubmed
    ..behaviour and neural conduction of sensation in the chronic eczema model was investigated by using l-histidine decarboxylase (HDC) gene knockout mice lacking histamine...
  2. Parmentier R, Ohtsu H, Djebbara Hannas Z, Valatx J, Watanabe T, Lin J. Anatomical, physiological, and pharmacological characteristics of histidine decarboxylase knock-out mice: evidence for the role of brain histamine in behavioral and sleep-wake control. J Neurosci. 2002;22:7695-711 pubmed
    ..or after behavioral or pharmacological stimuli in wild-type (WT) and knock-out mice lacking the histidine decarboxylase gene (HDC-/-)...
  3. Shen Y, He P, Fan Y, Zhang J, Yan H, Hu W, et al. Carnosine protects against permanent cerebral ischemia in histidine decarboxylase knockout mice by reducing glutamate excitotoxicity. Free Radic Biol Med. 2010;48:727-35 pubmed publisher
    ..we found that carnosine significantly improved neurological function and decreased infarct size in both histidine decarboxylase knockout and the corresponding wild-type mice to the same extent...
  4. Ohtsu H, Tanaka S, Terui T, Hori Y, Makabe Kobayashi Y, Pejler G, et al. Mice lacking histidine decarboxylase exhibit abnormal mast cells. FEBS Lett. 2001;502:53-6 pubmed
    b>Histidine decarboxylase (HDC) synthesizes histamine from histidine in mammals. To evaluate the role of histamine, we generated HDC-deficient mice using a gene targeting method...
  5. Yanovsky Y, Zigman J, Kernder A, Bein A, Sakata I, Osborne Lawrence S, et al. Proton- and ammonium-sensing by histaminergic neurons controlling wakefulness. Front Syst Neurosci. 2012;6:23 pubmed publisher
    ..We also developed a novel HDC-Cre transgenic reporter mouse line in which histaminergic TMN neurons can be visualized...
  6. Ohtsu H, Kuramasu A, Tanaka S, Terui T, Hirasawa N, Hara M, et al. Plasma extravasation induced by dietary supplemented histamine in histamine-free mice. Eur J Immunol. 2002;32:1698-708 pubmed
    b>Histidine decarboxylase (HDC) synthesizes endogenous histamine from histidine in mammals. To evaluate the role of histamine in skin allergic reaction, we used HDC gene knockout mice lacking histamine...
  7. Liu L, Zhang S, Zhu Y, Fu Q, Zhu Y, Gong Y, et al. Improved learning and memory of contextual fear conditioning and hippocampal CA1 long-term potentiation in histidine decarboxylase knock-out mice. Hippocampus. 2007;17:634-41 pubmed
    ..However, the results seem to be controversial in many behavioral tasks. In the present study, we used HDC knockout (HDC-KO) mice to investigate the effects of long-term histamine deficiency on learning and memory in ..
  8. Ohtsu H, Watanabe T. New functions of histamine found in histidine decarboxylase gene knockout mice. Biochem Biophys Res Commun. 2003;305:443-7 pubmed
    ..Histamine synthesis is uniquely catalyzed by L-histidine decarboxylase. The knockout mice of this gene express no histamine-producing activity and lack histamine...
  9. Chepkova A, Yanovsky E, Parmentier R, Ohtsu H, Haas H, Lin J, et al. Histamine receptor expression, hippocampal plasticity and ammonia in histidine decarboxylase knockout mice. Cell Mol Neurobiol. 2012;32:17-25 pubmed publisher
    Genetic ablation of the histamine producing enzyme histidine decarboxylase (HDC) leads to alteration in exploratory behaviour and hippocampus-dependent learning...

More Information


  1. Sasaguri Y, Wang K, Tanimoto A, Tsutsui M, Ueno H, Murata Y, et al. Role of histamine produced by bone marrow-derived vascular cells in pathogenesis of atherosclerosis. Circ Res. 2005;96:974-81 pubmed
    To clarify the role of histamine-producing cells and its origin in atherosclerosis, we investigated histidine decarboxylase (HDC; histamine-producing enzyme) expression in murine arteries with vascular injuries after the animal had ..
  2. Suzuki Ishigaki S, Numayama Tsuruta K, Kuramasu A, Sakurai E, Makabe Y, Shimura S, et al. The mouse L-histidine decarboxylase gene: structure and transcriptional regulation by CpG methylation in the promoter region. Nucleic Acids Res. 2000;28:2627-33 pubmed
    To investigate the regulation of mouse L-histidine decarboxylase (HDC) gene expression, we isolated genomic DNA clones encoding HDC...
  3. Karlstedt K, Nissinen M, Michelsen K, Panula P. Multiple sites of L-histidine decarboxylase expression in mouse suggest novel developmental functions for histamine. Dev Dyn. 2001;221:81-91 pubmed
    ..To clarify the developmental role of histamine, we have examined the developmental expression of L-histidine decarboxylase (HDC) mRNA and the production of histamine during mouse development...
  4. Anaclet C, Parmentier R, Ouk K, Guidon G, Buda C, Sastre J, et al. Orexin/hypocretin and histamine: distinct roles in the control of wakefulness demonstrated using knock-out mouse models. J Neurosci. 2009;29:14423-38 pubmed publisher
    ..sleep-wake phenotypes of orexin (Ox) knock-out (-/-) mice and compared them with those of histidine-decarboxylase (HDC, HA-synthesizing enzyme)-/- mice...
  5. Zecharia A, Yu X, Götz T, Ye Z, Carr D, Wulff P, et al. GABAergic inhibition of histaminergic neurons regulates active waking but not the sleep-wake switch or propofol-induced loss of consciousness. J Neurosci. 2012;32:13062-75 pubmed
    ..hypotheses in mice by genetically removing ionotropic GABA(A) or metabotropic GABA(B) receptors from histidine decarboxylase-expressing neurons...
  6. Baldan L, Williams K, Gallezot J, Pogorelov V, Rapanelli M, Crowley M, et al. Histidine decarboxylase deficiency causes tourette syndrome: parallel findings in humans and mice. Neuron. 2014;81:77-90 pubmed publisher
    ..A mutation in histidine decarboxylase (Hdc), the key enzyme for the biosynthesis of histamine (HA), has been implicated as a rare genetic cause...
  7. Wiener Z, Andrásfalvy M, Pallinger E, Kovacs P, Szalai C, Erdei A, et al. Bone marrow-derived mast cell differentiation is strongly reduced in histidine decarboxylase knockout, histamine-free mice. Int Immunol. 2002;14:381-7 pubmed
    ..In this study the development of bone marrow-derived mast cells was examined from histidine decarboxylase deficient (HDC-/-) and wild-type mice in the presence of IL-3...
  8. Yokoyama M, Yokoyama A, Mori S, Takahashi H, Yoshino T, Watanabe T, et al. Inducible histamine protects mice from P. acnes-primed and LPS-induced hepatitis through H2-receptor stimulation. Gastroenterology. 2004;127:892-902 pubmed
    ..injury and lethality in Propionibacterium acnes -primed and lipopolysaccharide-induced hepatitis, using histidine decarboxylase knockout and H2-receptor knockout mice...
  9. Paria B, Das N, Das S, Zhao X, Dileepan K, Dey S. Histidine decarboxylase gene in the mouse uterus is regulated by progesterone and correlates with uterine differentiation for blastocyst implantation. Endocrinology. 1998;139:3958-66 pubmed
    ..Histamine is formed from L-histidine by histidine decarboxylase (HDC)...
  10. Carlos D, Fremond C, Samarina A, Vasseur V, Maillet I, Ramos S, et al. Histamine plays an essential regulatory role in lung inflammation and protective immunity in the acute phase of Mycobacterium tuberculosis infection. Infect Immun. 2009;77:5359-68 pubmed publisher
    ..We used a model of pulmonary Mycobacterium tuberculosis infection in histamine-deficient mice lacking histidine decarboxylase (HDC(-/-)), the histamine-synthesizing enzyme...
  11. Rajasekaran N, Solomon S, Watanabe T, Ohtsu H, Gajda M, Bräuer R, et al. Histidine decarboxylase but not histamine receptor 1 or 2 deficiency protects from K/BxN serum-induced arthritis. Int Immunol. 2009;21:1263-8 pubmed publisher
    ..Mice deficient in histidine decarboxylase (HDC(-/-)) that do not produce histamine and mice deficient for histamine receptor 1 (H1R(-/-)) or ..
  12. Ghosh A, Hirasawa N, Ohtsu H, Watanabe T, Ohuchi K. Defective angiogenesis in the inflammatory granulation tissue in histidine decarboxylase-deficient mice but not in mast cell-deficient mice. J Exp Med. 2002;195:973-82 pubmed
    We have analyzed the role of histamine in the angiogenesis of the granulation tissue in histidine decarboxylase-deficient (HDC(-/-)) mice, mast cell-deficient mice (WBB6F1-W/W(V)), and their corresponding wild-type mice (HDC(+/+) and ..
  13. Gao C, Ganesh B, Shi Z, Shah R, Fultz R, Major A, et al. Gut Microbe-Mediated Suppression of Inflammation-Associated Colon Carcinogenesis by Luminal Histamine Production. Am J Pathol. 2017;187:2323-2336 pubmed publisher
    ..b>Histidine decarboxylase (HDC) deficiency has been shown to promote inflammation-associated colorectal cancer by accumulation of ..
  14. Uygun D, Ye Z, Zecharia A, Harding E, Yu X, Yustos R, et al. Bottom-Up versus Top-Down Induction of Sleep by Zolpidem Acting on Histaminergic and Neocortex Neurons. J Neurosci. 2016;36:11171-11184 pubmed
    ..This knowledge could help in the design of sleeping pills that induce a more natural sleep. ..
  15. Meng F, Onori P, Hargrove L, Han Y, Kennedy L, Graf A, et al. Regulation of the histamine/VEGF axis by miR-125b during cholestatic liver injury in mice. Am J Pathol. 2014;184:662-73 pubmed publisher
    Histamine is formed by the conversion of l-histidine into histamine by histidine decarboxylase (HDC)...
  16. Martin S, Taylor B, Watanabe T, Bulfield G. Histidine decarboxylase phenotypes of inbred mouse strains: a regulatory locus (Hdc) determines kidney enzyme concentration. Biochem Genet. 1984;22:305-22 pubmed
    Mouse kidney histidine decarboxylase (HDC) provides a model system to study genetic control of a hormone-regulated enzyme (inducible by estrogen and thyroxine; repressible by testosterone)...
  17. Morgan T, Montgomery K, Mason V, West R, Wang L, van de Rijn M, et al. Upregulation of histidine decarboxylase expression in superficial cortical nephrons during pregnancy in mice and women. Kidney Int. 2006;70:306-14 pubmed
    ..b>Histidine decarboxylase (HDC), the enzyme that synthesizes histamine, was markedly upregulated in the mouse kidney during ..
  18. Horvath Z, Pallinger E, Horváth G, Jelinek I, Veszely G, Furesz J, et al. Extramedullary hematopoiesis is dysregulated in histamine-free histidine decarboxylase knockout (HDC-/-) mice. Inflamm Res. 2010;59:429-36 pubmed publisher
    In this study we investigated the role of histamine on the extramedullary hematopoiesis. Male histidine decarboxylase knockout (HDC(-/-)) mice and wild-type mice were used (n = 5/group)...
  19. Pos Z, Muller K, Novalphak I, Buzas E, Solbach W, Falus A, et al. Different patterns of the L-histidine decarboxylase (HDC) gene expression in mice resistant and susceptible to experimental cutaneous leishmaniasis. Inflamm Res. 2004;53:38-43 pubmed
    ..AND METHODS: A novel RNase Protection Assay (RPA) was developed and applied for the assessment of L-histidine decarboxylase (HDC) gene expression in organs of resistant C57BL/6 and susceptible BALB/c mice after infection with L...
  20. Wang K, Tanimoto A, Guo X, Yamada S, Shimajiri S, Murata Y, et al. Histamine deficiency decreases atherosclerosis and inflammatory response in apolipoprotein E knockout mice independently of serum cholesterol level. Arterioscler Thromb Vasc Biol. 2011;31:800-7 pubmed publisher
    ..In the present study, we generated apolipoprotein E (apoE) and histamine synthesizing histidine decarboxylase double knockout (DKO) mice on a C57BL/6J (wild-type mice) background to clarify the roles of histamine in ..
  21. Graf A, Meng F, Hargrove L, Kennedy L, Han Y, Francis T, et al. Knockout of histidine decarboxylase decreases bile duct ligation-induced biliary hyperplasia via downregulation of the histidine decarboxylase/VEGF axis through PKA-ERK1/2 signaling. Am J Physiol Gastrointest Liver Physiol. 2014;307:G813-23 pubmed publisher
    Histidine is converted to histamine by histidine decarboxylase (HDC). We have shown that cholangiocytes 1) express HDC, 2) secrete histamine, and 3) proliferate after histamine treatment via ERK1/2 signaling...
  22. Jenny M, Uhl C, Roche C, Duluc I, Guillermin V, Guillemot F, et al. Neurogenin3 is differentially required for endocrine cell fate specification in the intestinal and gastric epithelium. EMBO J. 2002;21:6338-47 pubmed
    ..Thus, ngn3 is strictly required for endocrine cell fate specification in multipotent intestinal progenitor cells, whereas gastric endocrine development is both ngn3 dependent and independent. ..
  23. Tamasi V, Fülöp A, Hegyi K, Monostory K, Falus A. Upregulation of CYP2e1 and CYP3a activities in histamine-deficient histidine decarboxylase gene targeted mice. Cell Biol Int. 2003;27:1011-5 pubmed
    ..Using histidine decarboxylase gene targeted (HDC(-/-)) BALB/c mice, we studied the effect of the absence of histamine on four ..
  24. Zhao C, Martinez V, Piqueras L, Wang L, TACHE Y, Chen D. Control of gastric acid secretion in somatostatin receptor 2 deficient mice: shift from endocrine/paracrine to neurocrine pathways. Endocrinology. 2008;149:498-505 pubmed
    ..The ECL cells displayed a reduced expression of histidine decarboxylase and vesicle monoamine transport type 2 (determined by immunohistochemistry), and an impaired ..
  25. Martin S, Bulfield G. A regulatory locus, Hdc-e, determines the response of mouse kidney histidine decarboxylase to estrogen. Biochem Genet. 1984;22:1037-46 pubmed
    Levels of histidine decarboxylase (HDC; EC activity in female mouse kidney are modulated by estrogen (administered as implanted pellets)...
  26. Parmentier R, Anaclet C, Guhennec C, Brousseau E, Bricout D, Giboulot T, et al. The brain H3-receptor as a novel therapeutic target for vigilance and sleep-wake disorders. Biochem Pharmacol. 2007;73:1157-71 pubmed
    ..Thus ciproxifan produced no increase in W in either histidine-decarboxylase (HDC, histamine-synthesizing enzyme) or H(1)- or H(3)-receptor KO-mice whereas its waking effects persisted in H(2)-..
  27. Nelson P, Lippke J, Murcko M, Rosborough S, Peattie D. cDNA encoding murine FK506-binding protein (FKBP): nucleotide and deduced amino acid sequence. Gene. 1991;109:255-8 pubmed
    ..Molecular modeling of the protein places the aa substitutions at positions not directly involved in drug binding or interaction with the potential drug target protein, calcineurin A. ..
  28. Garaczi E, Szell M, Jánossy T, Koreck A, Pivarcsi A, Buzas E, et al. Negative regulatory effect of histamine in DNFB-induced contact hypersensitivity. Int Immunol. 2004;16:1781-8 pubmed
    ..histamine in contact hypersensitivity, contact dermatitis was induced with dinitrofluorobenzene (DNFB) in histidine decarboxylase knockout (HDC-/-) histamine-deficient and wild-type mice...
  29. Andou A, Hisamatsu T, Okamoto S, Chinen H, Kamada N, Kobayashi T, et al. Dietary histidine ameliorates murine colitis by inhibition of proinflammatory cytokine production from macrophages. Gastroenterology. 2009;136:564-74.e2 pubmed publisher
    ..Thus, our studies provided new insights into the roles of amino acid metabolism in the pathophysiology of CD and for therapeutic strategies. ..
  30. Tanaka Y, Nagai Y, Kuroishi T, Endo Y, Sugawara S. Stimulation of Ly-6G on neutrophils in LPS-primed mice induces platelet-activating factor (PAF)-mediated anaphylaxis-like shock. J Leukoc Biol. 2012;91:485-94 pubmed publisher
    ..These findings may be related to adult respiratory distress syndrome, although the natural ligand for Ly-6G remains to be identified. ..
  31. Martin S, Bulfield C. Genetic analysis of a new haplotype of the histidine decarboxylase gene complex in C57BL/6 mice. Genet Res. 1986;47:131-4 pubmed
  32. Hirai T, Okuma C, Harada C, Mio M, Ohtsu H, Watanabe T, et al. Development of amygdaloid kindling in histidine decarboxylase-deficient and histamine H1 receptor-deficient mice. Epilepsia. 2004;45:309-13 pubmed
    ..the role of histamine or histamine H1 receptors in the development of amygdaloid kindling by using histidine decarboxylase (HDC)-deficient and histamine H1 receptor (H1R)-deficient mice...
  33. Greferath U, Vessey K, Jobling A, Mills S, Bui B, He Z, et al. The role of histamine in the retina: studies on the Hdc knockout mouse. PLoS ONE. 2014;9:e116025 pubmed publisher
    ..of the retina in mice that lacked expression of the rate limiting enzyme in the formation of histamine, histidine decarboxylase (Hdc-/- mouse)...
  34. Csaba G, Kovacs P, Buzas E, Mazan M, Pallinger E. Histidine decarboxylase (HDC) knock out mouse immune cells have altered expression of ACTH, triiodothyronine and endorphin. Inflamm Res. 2007;56:428-31 pubmed
    ..Knock-out of the histidine decarboxylase gene causes a general endocrine imbalance in the hormones which are related to histamine, inside the ..
  35. Malzac P, Mattei M, Thibault J, Bruneau G. Chromosomal localization of the human and mouse histidine decarboxylase genes by in situ hybridization. Exclusion of the HDC gene from the Prader-Willi syndrome region. Hum Genet. 1996;97:359-61 pubmed
    Using a rat histidine decarboxylase (HDC) cDNA probe, we have mapped the HDC gene by in situ hybridization to the q15-q21 region of human chromosome 15 and to the E5-G region of murine chromosome 2...
  36. Jørgensen E, Vogelsang T, Knigge U, Watanabe T, Warberg J, Kjaer A. Increased susceptibility to diet-induced obesity in histamine-deficient mice. Neuroendocrinology. 2006;83:289-94 pubmed
    ..Histamine-deficient histidine decarboxylase knock-out (HDC-KO) mice and C57BL/6J wild-type (WT) mice were given either a standard diet (STD) or HFD ..
  37. Pap E, Racz K, Kovács J, Varga I, Buzas E, Madarasz B, et al. Histidine decarboxylase deficiency in gene knockout mice elevates male sex steroid production. J Endocrinol. 2002;175:193-9 pubmed
    Histamine is synthesized in cells by histidine decarboxylase (HDC). HDC-deficient knockout (KO) mice lack functional HDC and histamine in the tissues...
  38. de la Brousse F, Birkenmeier E, King D, Rowe L, McKnight S. Molecular and genetic characterization of GABP beta. Genes Dev. 1994;8:1853-65 pubmed
    ..Finally, evidence is presented showing that GABP beta 1-1 and GABP beta 2-1 can heterodimerize through this carboxy-terminal domain, but neither protein can heterodimerize via the dimer-forming region of the bZIP protein C/EBP beta. ..
  39. Abdurakhmanova S, Chary K, Kettunen M, Sierra A, Panula P. Behavioral and stereological characterization of Hdc KO mice: Relation to Tourette syndrome. J Comp Neurol. 2017;525:3476-3487 pubmed publisher
    A premature termination codon in the human histidine decarboxylase (Hdc) gene has been identified in a family suffering from Guilles de la Tourette syndrome (GTS)...
  40. Leite de Moraes M, Diem S, Michel M, Ohtsu H, Thurmond R, Schneider E, et al. Cutting edge: histamine receptor H4 activation positively regulates in vivo IL-4 and IFN-gamma production by invariant NKT cells. J Immunol. 2009;182:1233-6 pubmed
    ..In this study we demonstrate that histamine-free histidine decarboxylase-deficient (HDC(-/-)) mice present a numerical and functional deficit in invariant NK T (iNKT) cells as ..
  41. Brabant C, Quertemont E, Anaclet C, Lin J, Ohtsu H, Tirelli E. The psychostimulant and rewarding effects of cocaine in histidine decarboxylase knockout mice do not support the hypothesis of an inhibitory function of histamine on reward. Psychopharmacology (Berl). 2007;190:251-63 pubmed
    ..inhibitory function, we assessed the stimulant and rewarding effects of cocaine in knockout mice lacking histidine decarboxylase (HDC KO mice), the histamine-synthesizing enzyme...
  42. Schneider E, Machavoine F, Pleau J, Bertron A, Thurmond R, Ohtsu H, et al. Organic cation transporter 3 modulates murine basophil functions by controlling intracellular histamine levels. J Exp Med. 2005;202:387-93 pubmed
    ..These drugs were no longer effective in histamine-free histidine decarboxylase (HDC)-deficient mice, in contrast with histamine itself...
  43. Nozaki K, Weis V, Wang T, Falus A, Goldenring J. Altered gastric chief cell lineage differentiation in histamine-deficient mice. Am J Physiol Gastrointest Liver Physiol. 2009;296:G1211-20 pubmed publisher
    ..We have examined histidine-decarboxylase (HDC)-deficient mice, which lack endogenous histamine synthesis, to evaluate the influence of histamine on ..
  44. Biosse Duplan M, Baroukh B, Dy M, de Vernejoul M, Saffar J. Histamine promotes osteoclastogenesis through the differential expression of histamine receptors on osteoclasts and osteoblasts. Am J Pathol. 2009;174:1426-34 pubmed publisher
    ..Thus, histamine acts directly on osteoclasts, osteoclast precursors, and osteoblasts, promoting osteoclastogenesis through autocrine/paracrine mechanisms. ..
  45. Jørgensen E, Knigge U, Watanabe T, Warberg J, Kjaer A. Histaminergic neurons are involved in the orexigenic effect of orexin-A. Neuroendocrinology. 2005;82:70-7 pubmed
    ..intracerebroventricularly and food intake measured in wild-type, histamine H(1)-receptor knockout or histidine decarboxylase knockout mice...
  46. Bruneau G, Nguyen V, Gros F, Bernheim A, Thibault J. Preparation of a rat brain histidine decarboxylase (HDC) cDNA probe by PCR and assignment of the human HDC gene to chromosome 15. Hum Genet. 1992;90:235-8 pubmed
    The formation of histamine from its precursor histidine is catalyzed by histidine decarboxylase (HDC), a pyridoxal phosphate (PLP)-dependent decarboxylase...
  47. Michelsen K, Lozada A, Kaslin J, Karlstedt K, Kukko Lukjanov T, Holopainen I, et al. Histamine-immunoreactive neurons in the mouse and rat suprachiasmatic nucleus. Eur J Neurosci. 2005;22:1997-2004 pubmed
    ..in the mouse and rat SCN that neither display immunoreactivity (-iry) for the HA-synthesizing enzyme histidine decarboxylase (HDC) nor contain HDC mRNA...
  48. Hori Y, Nihei Y, Kurokawa Y, Kuramasu A, Makabe Kobayashi Y, Terui T, et al. Accelerated clearance of Escherichia coli in experimental peritonitis of histamine-deficient mice. J Immunol. 2002;169:1978-83 pubmed
    ..coli into the peritoneal cavity of the histamine-deficient mice generated by a disruption of the gene for histidine decarboxylase (HDC), the unique histamine-synthesizing enzyme. When we inoculated E...
  49. Makabe Kobayashi Y, Hori Y, Adachi T, Ishigaki Suzuki S, Kikuchi Y, Kagaya Y, et al. The control effect of histamine on body temperature and respiratory function in IgE-dependent systemic anaphylaxis. J Allergy Clin Immunol. 2002;110:298-303 pubmed
    ..the role of histamine in each of these symptoms, we induced the passive systemic anaphylaxis reaction in histidine decarboxylase gene knockout (HDC [-/-]) mice, which lack histamine...
  50. Provensi G, Coccurello R, Umehara H, Munari L, Giacovazzo G, Galeotti N, et al. Satiety factor oleoylethanolamide recruits the brain histaminergic system to inhibit food intake. Proc Natl Acad Sci U S A. 2014;111:11527-32 pubmed publisher
    ..effect of OEA is significantly attenuated in mice deficient in the histamine-synthesizing enzyme histidine decarboxylase (HDC-KO) or acutely depleted of histamine via interocerebroventricular infusion of the HDC blocker ?-..
  51. Yu X, Bauer K, Wernhoff P, Koczan D, Möller S, Thiesen H, et al. Fine mapping of collagen-induced arthritis quantitative trait loci in an advanced intercross line. J Immunol. 2006;177:7042-9 pubmed
    ..In addition, this study revealed that Cia27 and Trmq3 controlling anti-CII IgG2a Ab and CD4:CD8 T cell ratio, respectively, also regulated CIA clinical phenotypes. ..
  52. Wiener Z, Toth S, Gócza E, Kobolak J, Falus A. Mouse embryonic stem cells express histidine decarboxylase and histamine H1 receptors. Inflamm Res. 2003;52 Suppl 1:S53-4 pubmed
  53. Martin S, Bulfield G. A structural gene (Hdc-s) for mouse kidney histidine decarboxylase. Biochem Genet. 1984;22:645-56 pubmed
    The concentration of mouse kidney histidine decarboxylase (HDC) is modulated by estrogen, testosterone, and thyroxine in a tissue-specific manner...
  54. Adamson M, Silver J, Kozak C. The mouse homolog of the Gibbon ape leukemia virus receptor: genetic mapping and a possible receptor function in rodents. Virology. 1991;183:778-81 pubmed
    ..We speculate that a functional receptor for GALV-related viruses was expressed during Mus evolution. ..
  55. Hess E, Jinnah H, Kozak C, Wilson M. Spontaneous locomotor hyperactivity in a mouse mutant with a deletion including the Snap gene on chromosome 2. J Neurosci. 1992;12:2865-74 pubmed
    ..The localization of the genetic abnormality in coloboma mice using the Snap gene marker will provide a powerful tool for studying the biologic basis of locomotor hyperactivity. ..
  56. Hirasawa N, Torigoe M, Kano K, Ohuchi K. Involvement of Sp1 in lipopolysaccharide-induced expression of HDC mRNA in RAW 264 cells. Biochem Biophys Res Commun. 2006;349:833-7 pubmed
    The involvement of Sp1 in the lipopolysaccharide (LPS)-induced transcription of HDC mRNA in the mouse macrophage-like cell line RAW 264 was analyzed...
  57. Vaes B, Ducy P, Sijbers A, Hendriks J, van Someren E, de Jong N, et al. Microarray analysis on Runx2-deficient mouse embryos reveals novel Runx2 functions and target genes during intramembranous and endochondral bone formation. Bone. 2006;39:724-38 pubmed
    ..In conclusion, our data show that a comparative genome-wide expression analysis of wild-type and mutant mouse models allows the examination of mutant phenotypes in complex tissues. ..
  58. Yu X, Zecharia A, Zhang Z, Yang Q, Yustos R, Jager P, et al. Circadian factor BMAL1 in histaminergic neurons regulates sleep architecture. Curr Biol. 2014;24:2838-44 pubmed publisher
    ..are silent during sleep, and start firing after wake onset; the released histamine, made by the enzyme histidine decarboxylase (HDC), enhances wakefulness. We found that hdc gene expression varies with time of day...
  59. Chen X, Deng H, Churchill M, Luchsinger L, Du X, Chu T, et al. Bone Marrow Myeloid Cells Regulate Myeloid-Biased Hematopoietic Stem Cells via a Histamine-Dependent Feedback Loop. Cell Stem Cell. 2017;21:747-760.e7 pubmed publisher
    ..physiologic circuit that controls quiescence of MB-HSCs and hematopoietic progenitors marked by histidine decarboxylase (Hdc)...
  60. Yamamoto J, Yatsunami K, Ohmori E, Sugimoto Y, Fukui T, Katayama T, et al. cDNA-derived amino acid sequence of L-histidine decarboxylase from mouse mastocytoma P-815 cells. FEBS Lett. 1990;276:214-8 pubmed
    The primary structure of L-histidine decarboxylase (HDC: L-histidine carboxy-lyase, EC 4.1.1...
  61. Yan H, Zhang X, Hu W, Ma J, Hou W, Zhang X, et al. Histamine H3 receptors aggravate cerebral ischaemic injury by histamine-independent mechanisms. Nat Commun. 2014;5:3334 pubmed publisher
    ..Interestingly, H1R and H2R antagonists, a histidine decarboxylase (HDC) inhibitor and HDC knockout all fail to compromise the protection by H3R blockade...
  62. Ohtsu H, Kuramasu A, Suzuki S, Igarashi K, Ohuchi Y, Sato M, et al. Histidine decarboxylase expression in mouse mast cell line P815 is induced by mouse peritoneal cavity incubation. J Biol Chem. 1996;271:28439-44 pubmed
    ..for 1 week in the peritoneal cavity of syngenic BDF1 mice, proliferate and express high levels of L-histidine decarboxylase (HDC) and mouse mast cell protease (MMCP)-6 mRNAs, indicating the ability of P815 cells to differentiate ..
  63. Hunyady B, Zolyomi A, Czimmer J, Mozsik G, Kozicz T, Buzas E, et al. Expanded parietal cell pool in transgenic mice unable to synthesize histamine. Scand J Gastroenterol. 2003;38:133-40 pubmed
    The histidine decarboxylase enzyme (HDC) is responsible for the synthesis of histamine in mammals. Histidine decarboxylase-deficient (HDC-/-) mice have recently been developed by targeted mutation of the HDC gene...
  64. Inami Y, Sasaki A, Andoh T, Kuraishi Y. Surfactant-induced chronic pruritus: Role of L-histidine decarboxylase expression and histamine production in epidermis. Acta Derm Venereol. 2014;94:645-50 pubmed publisher
    ..SDS treatment increased the gene expression and post-translation processing of L-histidine decarboxylase in the epidermis...
  65. Quintana F, Buzas E, Prohaszka Z, Biro A, Kocsis J, Fust G, et al. Knock-out of the histidine decarboxylase gene modifies the repertoire of natural autoantibodies. J Autoimmun. 2004;22:297-305 pubmed
    ..an ELISA assay to characterize the self-antigen binding repertoires of NA in wild type (WT) mice and in histidine decarboxylase knock-out (HDC-KO) mice, unable to synthesize histamine...
  66. Paul R, Schuetze S, Kozak S, Kozak C, Kabat D. The Sfpi-1 proviral integration site of Friend erythroleukemia encodes the ets-related transcription factor Pu.1. J Virol. 1991;65:464-7 pubmed
    ..Genetic methods were used to map Sfpi-1 with respect to other loci on mouse chromosome 2. Our results suggest that Pu.1 blocks erythroblast differentiation and thereby causes immortalization. ..
  67. Rapanelli M, Frick L, Pogorelov V, Ohtsu H, Bito H, Pittenger C. Histamine H3R receptor activation in the dorsal striatum triggers stereotypies in a mouse model of tic disorders. Transl Psychiatry. 2017;7:e1013 pubmed publisher
    ..dysregulation has been identified as a rare genetic cause of tic disorders; mice with a knockout of the histidine decarboxylase (Hdc) gene represent a promising pathophysiologically grounded model...
  68. Kozma G, Losonczy G, Keszei M, Komlósi Z, Buzas E, Pallinger E, et al. Histamine deficiency in gene-targeted mice strongly reduces antigen-induced airway hyper-responsiveness, eosinophilia and allergen-specific IgE. Int Immunol. 2003;15:963-73 pubmed
    ..We have used histidine decarboxylase gene-targeted (HDC-KO) mice, lacking histamine, to investigate the effect of histamine deficiency in an ..
  69. Birkenmeier E, Schneider U, Thurston S. Fingerprinting genomes by use of PCR with primers that encode protein motifs or contain sequences that regulate gene expression. Mamm Genome. 1992;3:537-45 pubmed
    ..The results demonstrated that motif sequence-tagged PCR products are reliable markers for mapping the mouse genome and that motif primers can also be used for genomic fingerprinting of many divergent species. ..
  70. Fulop A, Földes A, Buzas E, Hegyi K, Miklós I, Romics L, et al. Hyperleptinemia, visceral adiposity, and decreased glucose tolerance in mice with a targeted disruption of the histidine decarboxylase gene. Endocrinology. 2003;144:4306-14 pubmed
    ..ability to produce histamine because of targeted disruption of the key enzyme in histamine biosynthesis (histidine decarboxylase, HDC)...
  71. Fogel W, Dudkowska M, Wagner W, Grzelakowska Sztabert B, Manteuffel Cymborowska M. Ornithine and histidine decarboxylase: activities in hypertrophic and hyperplastic mouse kidney. Inflamm Res. 2005;54 Suppl 1:S62-3 pubmed
  72. Safina F, Tanaka S, Inagaki M, Tsuboi K, Sugimoto Y, Ichikawa A. Expression of L-histidine decarboxylase in mouse male germ cells. J Biol Chem. 2002;277:14211-5 pubmed
    ..Based on this analogy, we investigated the expression of histidine decarboxylase (HDC), the rate-limiting enzyme of histamine synthesis, in mouse male germ cells...
  73. Koncz A, Pasztoi M, Mazan M, Fazakas F, Buzas E, Falus A, et al. Nitric oxide mediates T cell cytokine production and signal transduction in histidine decarboxylase knockout mice. J Immunol. 2007;179:6613-9 pubmed
    ..suggest the role of histamine in T cell activation and accelerated Th1 immune response is a hallmark of histidine decarboxylase knockout (HDC-KO) mice, with a complete lack of endogenously produced histamine...
  74. Gong Y, Zhang W, Shou W, Zhong K, Chen Z. Morphine induces conditioned place preference behavior in histidine decarboxylase knockout mice. Neurosci Lett. 2010;468:115-9 pubmed publisher
    ..investigate the involvement of endogenous histamine in morphine-induced reward-seeking behavior using histidine decarboxylase gene knockout (HDC-KO) mice...
  75. Musio S, Gallo B, Scabeni S, Lapilla M, Poliani P, Matarese G, et al. A key regulatory role for histamine in experimental autoimmune encephalomyelitis: disease exacerbation in histidine decarboxylase-deficient mice. J Immunol. 2006;176:17-26 pubmed
    ..contribution of endogenous histamine to the expression of EAE, we attempted to induce EAE in histidine decarboxylase-deficient mice, which are genetically unable to make histamine...
  76. Yamamoto J, Fukui T, Suzuki K, Tanaka S, Yatsunami K, Ichikawa A. Expression and characterization of recombinant mouse mastocytoma histidine decarboxylase. Biochim Biophys Acta. 1993;1216:431-40 pubmed
    The possibility of post-translational processing of mouse mastocytoma histidine decarboxylase (HDC; EC was investigated...
  77. Carlson G, Ebeling C, Torchia M, Westaway D, Prusiner S. Delimiting the location of the scrapie prion incubation time gene on chromosome 2 of the mouse. Genetics. 1993;133:979-88 pubmed
    ..Thus, Prn-pb transgenes and Prn-i may modulate scrapie pathogenesis by different mechanisms. ..
  78. Nakazawa S, Sakanaka M, Furuta K, Natsuhara M, Takano H, Tsuchiya S, et al. Histamine synthesis is required for granule maturation in murine mast cells. Eur J Immunol. 2014;44:204-14 pubmed publisher
    ..The synthesis of histamine is catalyzed by histidine decarboxylase (HDC)...
  79. Tan X, Essengue S, Talreja J, Reese J, Stechschulte D, Dileepan K. Histamine directly and synergistically with lipopolysaccharide stimulates cyclooxygenase-2 expression and prostaglandin I(2) and E(2) production in human coronary artery endothelial cells. J Immunol. 2007;179:7899-906 pubmed
    ..that the expression of COX-2 mRNA, but not COX-1 mRNA, was markedly reduced in the aortic tissues of histidine decarboxylase null mice...
  80. Hirasawa N, Ohtsu H, Watanabe T, Ohuchi K. Enhancement of neutrophil infiltration in histidine decarboxylase-deficient mice. Immunology. 2002;107:217-21 pubmed
    ..permeability and leucocyte infiltration were analysed in an air pouch-type allergic inflammation model in histidine decarboxylase-deficient (HDC-/-) mice and wild-type mice...
  81. Kennedy L, Hargrove L, Demieville J, Bailey J, Dar W, Polireddy K, et al. Knockout of l-Histidine Decarboxylase Prevents Cholangiocyte Damage and Hepatic Fibrosis in Mice Subjected to High-Fat Diet Feeding via Disrupted Histamine/Leptin Signaling. Am J Pathol. 2018;188:600-615 pubmed publisher
    ..Wild-type (WT) and l-histidine decarboxylase (Hdc-/-) mice were fed a control diet or an HFD coupled with a high fructose corn syrup ..
  82. Yoshida A, Mobarakeh J, Sakurai E, Sakurada S, Orito T, Kuramasu A, et al. Intrathecally-administered histamine facilitates nociception through tachykinin NK1 and histamine H1 receptors: a study in histidine decarboxylase gene knockout mice. Eur J Pharmacol. 2005;522:55-62 pubmed
    ..To study the participation of histamine in pain perception, histidine decarboxylase knockout mice were examined for pain threshold by means of three different kinds of noxious stimuli: ..
  83. Fitzpatrick L, Buzas E, Gagne T, Nagy A, Horvath C, Ferencz V, et al. Targeted deletion of histidine decarboxylase gene in mice increases bone formation and protects against ovariectomy-induced bone loss. Proc Natl Acad Sci U S A. 2003;100:6027-32 pubmed
    Targeted disruption of the histidine decarboxylase gene (HDC(-/-)), the only histamine-synthesizing enzyme, led to a histamine-deficient mice characterized by undetectable tissue histamine levels, impaired gastric acid secretion, ..
  84. Na J, Nam K, Choi H, Inui S, Youn S, Huh C, et al. Histidine decarboxylase expression influences the neofolliculogenesis of newborn mouse dermal cells. J Dermatol Sci. 2012;67:95-100 pubmed publisher
    ..newborn mouse dermal cells disappeared in the first few days of life and there was a drastic decrease of histidine decarboxylase (HDC) gene expression from postnatal day 0 (p0) to day 7 (p7)...
  85. Jelinek I, László V, Buzas E, Pallinger E, Hangya B, Horvath Z, et al. Increased antigen presentation and T(h)1 polarization in genetically histamine-free mice. Int Immunol. 2007;19:51-8 pubmed
    ..Using a genetically histamine-free [histidine decarboxylase knockout (HDC-/-)] mouse model, we examined the effects of histamine on DC-mediated antigen presentation...