Gene Symbol: Hdac5
Description: histone deacetylase 5
Alias: AI426555, Hdac4, mHDA1, mKIAA0600, histone deacetylase 5, HD5, histone deacetylase 4, histone deacetylase mHDA1
Species: mouse
Products:     Hdac5

Top Publications

  1. Li H, Xie H, Liu W, Hu R, Huang B, Tan Y, et al. A novel microRNA targeting HDAC5 regulates osteoblast differentiation in mice and contributes to primary osteoporosis in humans. J Clin Invest. 2009;119:3666-77 pubmed publisher
    ..a new miRNA (miR-2861) in primary mouse osteoblasts that promotes osteoblast differentiation by repressing histone deacetylase 5 (HDAC5) expression at the post-transcriptional level...
  2. Backs J, Backs T, Bezprozvannaya S, McKinsey T, Olson E. Histone deacetylase 5 acquires calcium/calmodulin-dependent kinase II responsiveness by oligomerization with histone deacetylase 4. Mol Cell Biol. 2008;28:3437-45 pubmed publisher
    Calcium/calmodulin-dependent protein kinase II (CaMKII) phosphorylates histone deacetylase 4 (HDAC4), a class IIa HDAC, resulting in the cytosolic accumulation of HDAC4 and the derepression of the transcription factor myocyte enhancer ..
  3. Vega R, Matsuda K, Oh J, Barbosa A, Yang X, Meadows E, et al. Histone deacetylase 4 controls chondrocyte hypertrophy during skeletogenesis. Cell. 2004;119:555-66 pubmed
    ..Here we report that HDAC4, which is expressed in prehypertrophic chondrocytes, regulates chondrocyte hypertrophy and endochondral bone ..
  4. Sparling D, Griesel B, Weems J, Olson A. GLUT4 enhancer factor (GEF) interacts with MEF2A and HDAC5 to regulate the GLUT4 promoter in adipocytes. J Biol Chem. 2008;283:7429-37 pubmed publisher
    ..Finally, we have demonstrated that the transcriptional co-repressor HDAC5 can interact with GEF in the absence of MEF2 proteins and specifically inhibit GLUT4 promoter activity...
  5. Ha C, Kim J, Zhao J, Wang W, Jhun B, Wong C, et al. PKA phosphorylates histone deacetylase 5 and prevents its nuclear export, leading to the inhibition of gene transcription and cardiomyocyte hypertrophy. Proc Natl Acad Sci U S A. 2010;107:15467-72 pubmed publisher
    ..Recent studies have identified several protein kinases that phosphorylate HDAC5, leading to its exportation from the nucleus...
  6. Potthoff M, Wu H, Arnold M, Shelton J, Backs J, McAnally J, et al. Histone deacetylase degradation and MEF2 activation promote the formation of slow-twitch myofibers. J Clin Invest. 2007;117:2459-67 pubmed
    ..These findings provide what we believe are new insights into the molecular basis of skeletal muscle function and have important implications for possible therapeutic interventions into muscular diseases. ..
  7. Long X, Creemers E, Wang D, Olson E, Miano J. Myocardin is a bifunctional switch for smooth versus skeletal muscle differentiation. Proc Natl Acad Sci U S A. 2007;104:16570-5 pubmed
    ..This repressor function of Myocd is complex, involving histone deacetylase 5 silencing of the Myog promoter and Myocd's physical contact with MyoD, which undermines MyoD DNA binding ..
  8. McKinsey T, Zhang C, Lu J, Olson E. Signal-dependent nuclear export of a histone deacetylase regulates muscle differentiation. Nature. 2000;408:106-11 pubmed
    ..MEF2 proteins also interact with the class II histone deacetylases HDAC4 and HDAC5, resulting in repression of MEF2-dependent genes...
  9. Chang S, McKinsey T, Zhang C, Richardson J, Hill J, Olson E. Histone deacetylases 5 and 9 govern responsiveness of the heart to a subset of stress signals and play redundant roles in heart development. Mol Cell Biol. 2004;24:8467-76 pubmed
    ..Here we report that mice lacking HDAC5 display a similar cardiac phenotype and develop profoundly enlarged hearts in response to pressure overload ..

More Information


  1. Verdin E, Dequiedt F, Kasler H. Class II histone deacetylases: versatile regulators. Trends Genet. 2003;19:286-93 pubmed
    ..We discuss their emerging biological functions and the molecular mechanisms by which they are regulated. ..
  2. Downes M, Ordentlich P, Kao H, Alvarez J, Evans R. Identification of a nuclear domain with deacetylase activity. Proc Natl Acad Sci U S A. 2000;97:10330-5 pubmed
    ..We demonstrate that HDAC5 and 7 can associate with at least 12 distinct proteins, including several members of the NuRD and Sin3A repression ..
  3. McKinsey T, Kuwahara K, Bezprozvannaya S, Olson E. Class II histone deacetylases confer signal responsiveness to the ankyrin-repeat proteins ANKRA2 and RFXANK. Mol Biol Cell. 2006;17:438-47 pubmed
    ..b>HDAC4 and HDAC5 interact with the ankyrin repeats of ANKRA2 and RFXANK and, through association with RFXANK, repress MHC ..
  4. Klappacher G, Lunyak V, Sykes D, Sawka Verhelle D, Sage J, Brard G, et al. An induced Ets repressor complex regulates growth arrest during terminal macrophage differentiation. Cell. 2002;109:169-80 pubmed
  5. Song P, Zhou Y, Coughlan K, Dai X, Xu H, Viollet B, et al. Adenosine monophosphate-activated protein kinase-?2 deficiency promotes vascular smooth muscle cell migration via S-phase kinase-associated protein 2 upregulation and E-cadherin downregulation. Arterioscler Thromb Vasc Biol. 2013;33:2800-9 pubmed publisher
    ..Finally, neointima formation after ligation of carotid artery was increased in AMPK?2(-/-), but not AMPK?1(-/-), mice. We conclude that deletion of AMPK?2 causes aberrant VSMC migration with accelerated neointima formation in vivo. ..
  6. Backs J, Olson E. Control of cardiac growth by histone acetylation/deacetylation. Circ Res. 2006;98:15-24 pubmed
    ..Manipulation of histone modifying enzymes and the signaling pathways that impinge on them in the settings of pathological cardiac growth, remodeling, and heart failure represents an auspicious therapeutic approach. ..
  7. Kwon I, Wang W, Xu S, Jin Z. Histone deacetylase 5 interacts with Krüppel-like factor 2 and inhibits its transcriptional activity in endothelium. Cardiovasc Res. 2014;104:127-37 pubmed publisher
    ..Here, we found that histone deacetylase 5 (HDAC5) associates with KLF2 and represses KLF2 transcriptional activation...
  8. Cho Y, Cavalli V. HDAC5 is a novel injury-regulated tubulin deacetylase controlling axon regeneration. EMBO J. 2012;31:3063-78 pubmed publisher
    ..by calcium influx at the site of injury, and requires protein kinase C-mediated activation of the histone deacetylase 5 (HDAC5)...
  9. Lazaro J, Bailey P, Lassar A. Cyclin D-cdk4 activity modulates the subnuclear localization and interaction of MEF2 with SRC-family coactivators during skeletal muscle differentiation. Genes Dev. 2002;16:1792-805 pubmed
  10. Descalzi G, Mitsi V, Purushothaman I, Gaspari S, Avrampou K, Loh Y, et al. Neuropathic pain promotes adaptive changes in gene expression in brain networks involved in stress and depression. Sci Signal. 2017;10: pubmed publisher
    ..Our study provides a resource of the changes in gene expression induced by long-term neuropathic pain in three distinct brain regions and reveals molecular connections between pain and chronic stress. ..
  11. Martin M, Kettmann R, Dequiedt F. Class IIa histone deacetylases: conducting development and differentiation. Int J Dev Biol. 2009;53:291-301 pubmed publisher
    ..Elucidating cellular and molecular mechanisms by which functions of class IIa HDACs are modulated could potentially lead to new therapeutic opportunities for various diseases. ..
  12. Zhou X, Richon V, Rifkind R, Marks P. Identification of a transcriptional repressor related to the noncatalytic domain of histone deacetylases 4 and 5. Proc Natl Acad Sci U S A. 2000;97:1056-61 pubmed
    ..HDACs have been identified in mammalian cells: the yeast RPD3 homologs HDAC1, 2, and 3 and the yeast HDA1 homologs HDAC4, 5, and 6. HDAC4 and HDAC5 contain a noncatalytic N-terminal domain...
  13. Gu X, Fu C, Lin L, Liu S, Su X, Li A, et al. miR-124 and miR-9 mediated downregulation of HDAC5 promotes neurite development through activating MEF2C-GPM6A pathway. J Cell Physiol. 2018;233:673-687 pubmed publisher
    ..Although it is known that HDAC5 regulates neuronal differentiation, neither the physiological function nor the regulation of HDAC5 in neuronal ..
  14. Czubryt M, McAnally J, Fishman G, Olson E. Regulation of peroxisome proliferator-activated receptor gamma coactivator 1 alpha (PGC-1 alpha ) and mitochondrial function by MEF2 and HDAC5. Proc Natl Acad Sci U S A. 2003;100:1711-6 pubmed
    ..of MEF2/HDAC interactions in the heart, we generated transgenic mice expressing a signal-resistant form of HDAC5 under cardiac-specific and doxycycline-inducible regulation...
  15. Xia S, Li X, Johnson T, Seidel C, Wallace D, Li R. Polycystin-dependent fluid flow sensing targets histone deacetylase 5 to prevent the development of renal cysts. Development. 2010;137:1075-84 pubmed publisher
    ..Here, we found that myocyte enhancer factor 2C (MEF2C) and histone deacetylase 5 (HDAC5), two key regulators of cardiac hypertrophy, are targets of polycystin-dependent fluid stress ..
  16. Witt O, Deubzer H, Milde T, Oehme I. HDAC family: What are the cancer relevant targets?. Cancer Lett. 2009;277:8-21 pubmed publisher
    ..The aim of this review is to discuss individual HDAC family members as drug targets in cancer taking into consideration their function under physiological conditions and their oncogenic potential in malignant disease. ..
  17. Lemercier C, Verdel A, Galloo B, Curtet S, Brocard M, Khochbin S. mHDA1/HDAC5 histone deacetylase interacts with and represses MEF2A transcriptional activity. J Biol Chem. 2000;275:15594-9 pubmed
    ..These data show that two independent class II histone deacetylases HDAC4 and HDAC5 are able to interact with members of the MEF2 transcription factor family and regulate their ..
  18. Mukwevho E, Kohn T, Lang D, Nyatia E, Smith J, Ojuka E. Caffeine induces hyperacetylation of histones at the MEF2 site on the Glut4 promoter and increases MEF2A binding to the site via a CaMK-dependent mechanism. Am J Physiol Endocrinol Metab. 2008;294:E582-8 pubmed publisher
    ..These data indicate that caffeine increases GLUT4 expression by acetylating the MEF2 site to increase MEF2A binding via a mechanism that involves CaMK II. ..
  19. Taniguchi M, Carreira M, Smith L, Zirlin B, Neve R, Cowan C. Histone deacetylase 5 limits cocaine reward through cAMP-induced nuclear import. Neuron. 2012;73:108-20 pubmed publisher
    ..here that cocaine and cyclic adenosine monophosphate (cAMP) signaling induce the transient nuclear accumulation of HDAC5 in rodent striatum...
  20. Verdel A, Khochbin S. Identification of a new family of higher eukaryotic histone deacetylases. Coordinate expression of differentiation-dependent chromatin modifiers. J Biol Chem. 1999;274:2440-5 pubmed
    ..Interestingly, one, mHDA2, encodes a protein with two putative deacetylase domains, and the other, mHDA1, contains only one deacetylase homology domain, located at the C-terminal half of the protein...
  21. Yoo E, Chung J, Choe S, Kim K, Kim J. Down-regulation of histone deacetylases stimulates adipocyte differentiation. J Biol Chem. 2006;281:6608-15 pubmed
    ..Together, these results suggest that the regulation of not only adipogenic transcription factors, but also chromatin-modifying enzymes is crucial for the execution of bona fide adipogenesis. ..
  22. Taniguchi M, Carreira M, Cooper Y, Bobadilla A, Heinsbroek J, Koike N, et al. HDAC5 and Its Target Gene, Npas4, Function in the Nucleus Accumbens to Regulate Cocaine-Conditioned Behaviors. Neuron. 2017;96:130-144.e6 pubmed publisher
    ..We found that dephosphorylated, nuclear histone deacetylase 5 (HDAC5) in the nucleus accumbens (NAc) reduced cocaine reward-context associations and relapse-like ..
  23. Cao D, Wang Z, Zhang C, Oh J, Xing W, Li S, et al. Modulation of smooth muscle gene expression by association of histone acetyltransferases and deacetylases with myocardin. Mol Cell Biol. 2005;25:364-76 pubmed
    ..These findings point to myocardin as a nexus for positive and negative regulation of smooth muscle gene expression by changes in chromatin acetylation. ..
  24. Berdeaux R, Goebel N, Banaszynski L, Takemori H, WANDLESS T, Shelton G, et al. SIK1 is a class II HDAC kinase that promotes survival of skeletal myocytes. Nat Med. 2007;13:597-603 pubmed
  25. McGee S, Swinton C, Morrison S, Gaur V, Campbell D, Jorgensen S, et al. Compensatory regulation of HDAC5 in muscle maintains metabolic adaptive responses and metabolism in response to energetic stress. FASEB J. 2014;28:3384-95 pubmed publisher
    ..Here, we show that in mouse muscle and myogenic cells, compensatory regulation of the histone deacetylase (HDAC5) transcriptional repressor maintains metabolic integrity...
  26. Castet A, Boulahtouf A, Versini G, Bonnet S, Augereau P, Vignon F, et al. Multiple domains of the Receptor-Interacting Protein 140 contribute to transcription inhibition. Nucleic Acids Res. 2004;32:1957-66 pubmed
    ..demonstrate that RIP140 associates in vitro not only with class I HDACs but also with class II enzymes such as HDAC5. This interaction mainly involves the N-terminus of RIP140 (residues 27-199) and two domains of HDAC5...
  27. van Rooij E, Fielitz J, Sutherland L, Thijssen V, Crijns H, Dimaio M, et al. Myocyte enhancer factor 2 and class II histone deacetylases control a gender-specific pathway of cardioprotection mediated by the estrogen receptor. Circ Res. 2010;106:155-65 pubmed publisher
    ..Here we show that the absence of HDAC5 or -9 in female mice protects against maladaptive remodeling following myocardial infarction, during which there ..
  28. Wein M, Liang Y, Göransson O, Sundberg T, Wang J, Williams E, et al. SIKs control osteocyte responses to parathyroid hormone. Nat Commun. 2016;7:13176 pubmed publisher
    ..Here we show that PTH inhibition of SOST (sclerostin), a WNT antagonist, requires HDAC4 and HDAC5, whereas PTH stimulation of RANKL, a stimulator of bone resorption, requires CRTC2...
  29. Tou L, Liu Q, Shivdasani R. Regulation of mammalian epithelial differentiation and intestine development by class I histone deacetylases. Mol Cell Biol. 2004;24:3132-9 pubmed
    ..Thus, modulation of endogenous class I HDAC levels represents a previously unappreciated mechanism to enable onset of tissue-restricted gene expression in a developing mammalian organ. ..
  30. Zhang C, McKinsey T, Lu J, Olson E. Association of COOH-terminal-binding protein (CtBP) and MEF2-interacting transcription repressor (MITR) contributes to transcriptional repression of the MEF2 transcription factor. J Biol Chem. 2001;276:35-9 pubmed
    ..These findings reveal CtBP-dependent and -independent mechanisms for transcriptional repression by MITR and show that MITR represses MEF2 activity through recruitment of multicomponent corepressor complexes that include CtBP and HDACs. ..
  31. Gong H, Xie J, Zhang N, Yao L, Zhang Y. MEF2A binding to the Glut4 promoter occurs via an AMPK?2-dependent mechanism. Med Sci Sports Exerc. 2011;43:1441-50 pubmed publisher
    The role of AMP-activated protein kinase ?2 (AMPK?2) in regulating MEF2A nucleus translocation, nuclear histone deacetylase 5 (HDAC5) association with MEF2, HDAC5 nuclear export, MEF2A binding to the Glut4 promoter, and GLUT4 expression ..
  32. Kang Y, Kim J, Anderson J, Wu J, Gleim S, Kundu R, et al. Apelin-APJ signaling is a critical regulator of endothelial MEF2 activation in cardiovascular development. Circ Res. 2013;113:22-31 pubmed publisher
    ..signaling pathway downstream of apelin-APJ involving G?13, which induces histone deacetylase (HDAC) 4 and HDAC5 phosphorylation and cytoplasmic translocation, resulting in activation of myocyte enhancer factor 2...
  33. Poralla L, Stroh T, Erben U, Sittig M, Liebig S, Siegmund B, et al. Histone deacetylase 5 regulates the inflammatory response of macrophages. J Cell Mol Med. 2015;19:2162-71 pubmed publisher
    ..We here specifically investigated the direct effects of HDAC5 in macrophage activation in response to bacterial or cytokine stimuli...
  34. Kabra D, Pfuhlmann K, García Cáceres C, Schriever S, Casquero García V, Kebede A, et al. Hypothalamic leptin action is mediated by histone deacetylase 5. Nat Commun. 2016;7:10782 pubmed publisher
    ..Here we identify histone deacetylase 5 (HDAC5) as a regulator of leptin signalling and organismal energy balance...
  35. Chang S, Young B, Li S, Qi X, Richardson J, Olson E. Histone deacetylase 7 maintains vascular integrity by repressing matrix metalloproteinase 10. Cell. 2006;126:321-34 pubmed
  36. Renthal W, Maze I, Krishnan V, Covington H, Xiao G, Kumar A, et al. Histone deacetylase 5 epigenetically controls behavioral adaptations to chronic emotional stimuli. Neuron. 2007;56:517-29 pubmed
    ..Here, we identify the activity-dependent class II histone deacetylase, HDAC5, as a central integrator of these stimuli with changes in chromatin structure and gene expression...
  37. Lenoir O, Flosseau K, Ma F, Blondeau B, Mai A, Bassel Duby R, et al. Specific control of pancreatic endocrine ?- and ?-cell mass by class IIa histone deacetylases HDAC4, HDAC5, and HDAC9. Diabetes. 2011;60:2861-71 pubmed publisher
    ..Analyses of the pancreas of class IIa HDAC mutant mice revealed an increased pool of insulin-producing ?-cells in Hdac5(-/-) and Hdac9(-/-) mice and an increased pool of somatostatin-producing ?-cells in Hdac4(-/-) and Hdac5(-/-) mice...
  38. Sen N, Kumari R, Singh M, Das S. HDAC5, a key component in temporal regulation of p53-mediated transactivation in response to genotoxic stress. Mol Cell. 2013;52:406-20 pubmed publisher
    ..Our data reveal that histone deacetylase 5 (HDAC5) binds to p53 and abrogates K120 acetylation, resulting in preferential recruitment of p53 to ..
  39. Liu P, Liu C. Epigenetics of amphetamine-induced sensitization: HDAC5 expression and microRNA in neural remodeling. J Biomed Sci. 2016;23:90 pubmed
    ..We aimed to examine in vivo HDAC5 expression in a preclinical model of amphetamine-induced sensitization (AIS) of behavior...
  40. Zhang Y, Matkovich S, Duan X, Diwan A, Kang M, Dorn G. Receptor-independent protein kinase C alpha (PKCalpha) signaling by calpain-generated free catalytic domains induces HDAC5 nuclear export and regulates cardiac transcription. J Biol Chem. 2011;286:26943-51 pubmed publisher
    ..PKC?-CT constitutively localizes to nuclei and directly promotes nucleo-cytoplasmic shuttling of HDAC5, inducing expression of apoptosis and other deleterious genes...
  41. Cho Y, Park D, Cavalli V. Filamin A is required in injured axons for HDAC5 activity and axon regeneration. J Biol Chem. 2015;290:22759-70 pubmed publisher
    ..We have previously identified HDAC5 as an injury-regulated tubulin deacetylase that functions at the injury site to promote axon regeneration...
  42. Yamaguchi N, Chakraborty A, Pasek D, Molkentin J, Meissner G. Dysfunctional ryanodine receptor and cardiac hypertrophy: role of signaling molecules. Am J Physiol Heart Circ Physiol. 2011;300:H2187-95 pubmed publisher
    ..5 hearts; rather increased Erk1/2 and p90RSK phosphorylation levels likely leading to reduced GSK-3? activity were found to precede development of cardiac hypertrophy in mice expressing dysfunctional ryanodine receptor ion channel. ..
  43. Gaur V, Connor T, Sanigorski A, Martin S, Bruce C, Henstridge D, et al. Disruption of the Class IIa HDAC Corepressor Complex Increases Energy Expenditure and Lipid Oxidation. Cell Rep. 2016;16:2802-2810 pubmed publisher
    ..Therefore, compounds that disrupt class IIa HDAC function could be used to enhance metabolic health in chronic diseases driven by physical inactivity. ..
  44. Han L, Pan Y, Wang B. Small ubiquitin-like Modifier (SUMO) modification inhibits GLI2 protein transcriptional activity in vitro and in vivo. J Biol Chem. 2012;287:20483-9 pubmed publisher
    ..Interestingly, GLI2 can interact with HDAC5 (histone deacetylase 5), but the GLI2 mutant cannot...
  45. Wein M, Spatz J, Nishimori S, Doench J, ROOT D, Babij P, et al. HDAC5 controls MEF2C-driven sclerostin expression in osteocytes. J Bone Miner Res. 2015;30:400-11 pubmed publisher
    ..The molecular mechanisms underlying SOST expression remain largely unexplored. Here, we report that histone deacetylase 5 (HDAC5) negatively regulates sclerostin levels in osteocytes in vitro and in vivo...
  46. Zhao J, Yue W, Zhu M, Du M. AMP-activated protein kinase regulates beta-catenin transcription via histone deacetylase 5. J Biol Chem. 2011;286:16426-34 pubmed publisher
    ..cell differentiation via altering ?-catenin expression, which involves phosphorylation of class IIa histone deacetylase 5 (HDAC5)...
  47. Watamoto K, Towatari M, Ozawa Y, Miyata Y, Okamoto M, Abe A, et al. Altered interaction of HDAC5 with GATA-1 during MEL cell differentiation. Oncogene. 2003;22:9176-84 pubmed
    ..interact with GATA-1 to regulate its function and indeed, GATA-1 is directly associated with HDAC3, HDAC4 and HDAC5. The expression profiling and our previous observation that GATA-2 interacts with members of the HDAC family ..
  48. Hu H, Li L, Wang C, He H, Mao K, Ma X, et al. 4-Phenylbutyric acid increases GLUT4 gene expression through suppression of HDAC5 but not endoplasmic reticulum stress. Cell Physiol Biochem. 2014;33:1899-910 pubmed
    ..Moreover, we also found that 4-PBA inhibited histonedeacetylase 5 (HDAC5) expression in C2C12 myotubes, resulting in hyperacetylation of the histone H3 at the myocyte enhancer factor 2 (..
  49. Obri A, Makinistoglu M, Zhang H, Karsenty G. HDAC4 integrates PTH and sympathetic signaling in osteoblasts. J Cell Biol. 2014;205:771-80 pubmed publisher
    ..In this paper, we show that PTH favors Rankl expression by triggering the ubiquitination of HDAC4, a class II histone deacetylase, via Smurf2...
  50. Dai Y, Xu J, Molkentin J. The DnaJ-related factor Mrj interacts with nuclear factor of activated T cells c3 and mediates transcriptional repression through class II histone deacetylase recruitment. Mol Cell Biol. 2005;25:9936-48 pubmed
    ..Collectively, our results define a novel response pathway whereby NFATc3 is negatively regulated by class II histone deacetylases through the DnaJ (heat shock protein-40) superfamily member Mrj. ..
  51. Ma L, Tang H, Yin Y, Yu R, Zhao J, Li Y, et al. HDAC5-mTORC1 Interaction in Differential Regulation of Ghrelin and Nucleobindin 2 (NUCB2)/Nesfatin-1. Mol Endocrinol. 2015;29:1571-80 pubmed publisher
    ..Alterations in ghrelin and nucleobindin 2/nesfatin-1 were mediated by HDAC5 but not HDAC4. Activation of mTORC1 significantly attenuated the effect of VPA on ghrelin and nesfatin-1 levels...
  52. Jia H, Li Q, Lv L. HDAC5 Inhibits Hepatic Lipogenic Genes Expression by Attenuating the Transcriptional Activity of Liver X Receptor. Cell Physiol Biochem. 2016;39:1561-7 pubmed publisher
    ..However, the exact role of HDAC5 in lipogenesis remains elusive...
  53. Valzania A, Catale C, Viscomi M, Puglisi Allegra S, Carola V. Histone deacetylase 5 modulates the effects of social adversity in early life on cocaine-induced behavior. Physiol Behav. 2017;171:7-12 pubmed publisher
    ..In particular, HDAC5 has an important modulatory function in cocaine-induced behaviors and social defeat stress-induced effects...
  54. Eom G, Nam Y, Oh J, Choe N, Min H, Yoo E, et al. Regulation of acetylation of histone deacetylase 2 by p300/CBP-associated factor/histone deacetylase 5 in the development of cardiac hypertrophy. Circ Res. 2014;114:1133-43 pubmed publisher
    ..activation mechanism of HDAC2 that involves acetylation of HDAC2 mediated by p300/CBP-associated factor/HDAC5. Hdac2 was acetylated in response to hypertrophic stresses in both cardiomyocytes and a mouse model...
  55. Kao H, Downes M, Ordentlich P, Evans R. Isolation of a novel histone deacetylase reveals that class I and class II deacetylases promote SMRT-mediated repression. Genes Dev. 2000;14:55-66 pubmed
    ..this model, a two-hybrid screen on SMRT-interacting proteins resulted in the isolation of the recently described HDAC5 and a new family member termed HDAC7...
  56. Grozinger C, Hassig C, Schreiber S. Three proteins define a class of human histone deacetylases related to yeast Hda1p. Proc Natl Acad Sci U S A. 1999;96:4868-73 pubmed
    ..The corresponding full-length cDNAs were cloned and defined as HDAC4, HDAC5, and HDAC6...
  57. Colussi C, Rosati J, Straino S, Spallotta F, Berni R, Stilli D, et al. N?-lysine acetylation determines dissociation from GAP junctions and lateralization of connexin 43 in normal and dystrophic heart. Proc Natl Acad Sci U S A. 2011;108:2795-800 pubmed publisher
    ..These results suggest that Cx43 N(?)-lysine acetylation may have physiopathological consequences for cell to cell coupling and cardiac function. ..
  58. Hsing C, Lin C, So E, Sun D, Chen T, Li C, et al. ?2-Adrenoceptor agonist dexmedetomidine protects septic acute kidney injury through increasing BMP-7 and inhibiting HDAC2 and HDAC5. Am J Physiol Renal Physiol. 2012;303:F1443-53 pubmed publisher
    ..Survival was monitored for 120 h. LPS increased HDAC2, HDAC5, TNF-?, and MCP-1 expression, but decreased BMP-7 expression in NRK52E cells...
  59. Takemori H, Katoh Hashimoto Y, Nakae J, Olson E, Okamoto M. Inactivation of HDAC5 by SIK1 in AICAR-treated C2C12 myoblasts. Endocr J. 2009;56:121-30 pubmed
    ..Treatment with AICAR or the overexpression of SIK1 induces nuclear export of HDAC5 followed by the activation of myogenic transcription factor (MEF)-2C...
  60. Erburu M, Muñoz Cobo I, Domínguez Andrés J, Beltran E, Suzuki T, Mai A, et al. Chronic stress and antidepressant induced changes in Hdac5 and Sirt2 affect synaptic plasticity. Eur Neuropsychopharmacol. 2015;25:2036-48 pubmed publisher
    ..CSDS increased Hdac5 and Sirt2 mRNA whereas repeated imipramine did the opposite...
  61. Potter G, Beaudoin G, DeRenzo C, Zarach J, Chen S, Thompson C. The hairless gene mutated in congenital hair loss disorders encodes a novel nuclear receptor corepressor. Genes Dev. 2001;15:2687-701 pubmed
    ..The discovery that Hr is a corepressor provides a molecular basis for specific hair loss syndromes in both humans and mice. ..
  62. Kang J, Alliston T, Delston R, Derynck R. Repression of Runx2 function by TGF-beta through recruitment of class II histone deacetylases by Smad3. EMBO J. 2005;24:2543-55 pubmed
    ..Accordingly, HDAC4 or 5 is required for efficient TGF-beta-mediated inhibition of Runx2 function and is involved in osteoblast ..
  63. Ferreira R, Popova E, James J, Briones M, Zhang S, Barnstable C. Histone Deacetylase 1 Is Essential for Rod Photoreceptor Differentiation by Regulating Acetylation at Histone H3 Lysine 9 and Histone H4 Lysine 12 in the Mouse Retina. J Biol Chem. 2017;292:2422-2440 pubmed publisher
    ..HDAC1 may be an essential epigenetic regulator of the transition from progenitor cells to terminally differentiated photoreceptors. ..
  64. Mitsi V, Terzi D, Purushothaman I, Manouras L, Gaspari S, Neve R, et al. RGS9-2--controlled adaptations in the striatum determine the onset of action and efficacy of antidepressants in neuropathic pain states. Proc Natl Acad Sci U S A. 2015;112:E5088-97 pubmed publisher
    ..affects several protein interactions, phosphoprotein levels, and the function of the epigenetic modifier histone deacetylase 5, which are important for TCA responsiveness...
  65. Lagha M, Sato T, Regnault B, Cumano A, Zuniga A, Licht J, et al. Transcriptome analyses based on genetic screens for Pax3 myogenic targets in the mouse embryo. BMC Genomics. 2010;11:696 pubmed publisher
    ..In the progenitor cell population, Pax7 and also Hdac5 which is a potential repressor of Foxc2, are subject to positive control by Pax3.
  66. Kurtev V, Margueron R, Kroboth K, Ogris E, Cavailles V, Seiser C. Transcriptional regulation by the repressor of estrogen receptor activity via recruitment of histone deacetylases. J Biol Chem. 2004;279:24834-43 pubmed
    ..In addition, we found that REA also associates with the class II histone deacetylase HDAC5. In luciferase reporter assays, REA decreased transcription, and this repression was sensitive to the deacetylase ..
  67. Delehanty L, Bullock G, Goldfarb A. Protein kinase D-HDAC5 signaling regulates erythropoiesis and contributes to erythropoietin cross-talk with GATA1. Blood. 2012;120:4219-28 pubmed publisher
    ..Here we show that erythropoietin regulates GATA1 through protein kinase D activation, promoting histone deacetylase 5 (HDAC5) dissociation from GATA1, and subsequent GATA1 acetylation...
  68. Su C, Su C, Hsiao Y, Gean P. Epigenetic regulation of BDNF in the learned helplessness-induced animal model of depression. J Psychiatr Res. 2016;76:101-10 pubmed publisher
    ..The expression of HDAC5 was up-regulated in the LH mice, and a ChIP assay revealed that the level of HDAC5 binding to the promoter region ..
  69. Bierne H, Tham T, Batsche E, Dumay A, Leguillou M, Kernéis Golsteyn S, et al. Human BAHD1 promotes heterochromatic gene silencing. Proc Natl Acad Sci U S A. 2009;106:13826-31 pubmed publisher
    ..This nuclear protein interacts with HP1, MBD1, HDAC5, and several transcription factors...
  70. Spiegelberg B, Hamm H. G betagamma binds histone deacetylase 5 (HDAC5) and inhibits its transcriptional co-repression activity. J Biol Chem. 2005;280:41769-76 pubmed
    ..effectors of the G betagamma subunit of heterotrimeric G proteins, we found that G betagamma binds to histone deacetylase 5 (HDAC5), an enzyme involved in a pathway not previously recognized to be directly impacted by G proteins...
  71. Liu Y, Hernández Ochoa E, Randall W, Schneider M. NOX2-dependent ROS is required for HDAC5 nuclear efflux and contributes to HDAC4 nuclear efflux during intense repetitive activity of fast skeletal muscle fibers. Am J Physiol Cell Physiol. 2012;303:C334-47 pubmed publisher
    Reactive oxygen species (ROS) have been linked to oxidation and nuclear efflux of class IIa histone deacetylase 4 (HDAC4) in cardiac muscle...
  72. Walkinshaw D, Weist R, Xiao L, Yan K, Kim G, Yang X. Dephosphorylation at a conserved SP motif governs cAMP sensitivity and nuclear localization of class IIa histone deacetylases. J Biol Chem. 2013;288:5591-605 pubmed publisher
    b>Histone deacetylase 4 (HDAC4) and its paralogs, HDAC5, -7, and -9 (all members of class IIa), possess multiple phosphorylation sites crucial for 14-3-3 binding and subsequent nuclear export...
  73. Medford H, Porter K, Marsh S. Immediate effects of a single exercise bout on protein O-GlcNAcylation and chromatin regulation of cardiac hypertrophy. Am J Physiol Heart Circ Physiol. 2013;305:H114-23 pubmed publisher
  74. Weems J, Griesel B, Olson A. Class II histone deacetylases downregulate GLUT4 transcription in response to increased cAMP signaling in cultured adipocytes and fasting mice. Diabetes. 2012;61:1404-14 pubmed publisher
    ..Chromatin immunoprecipitation experiments showed the association of HDAC4/5 with the GLUT4 promoter in vivo and in vitro in response to elevated cAMP...