Gene Symbol: Hdac3
Description: histone deacetylase 3
Alias: AW537363, histone deacetylase 3, HD3, HDAC3 splicing HDAC3alpha, HDAC3 splicing HDAC3beta, HDAC3 splicing HDAC3delta, HDAC3 splicing HDAC3gamma
Species: mouse
Products:     Hdac3

Top Publications

  1. Downes M, Ordentlich P, Kao H, Alvarez J, Evans R. Identification of a nuclear domain with deacetylase activity. Proc Natl Acad Sci U S A. 2000;97:10330-5 pubmed
    ..We demonstrate that HDAC5 and 7 can associate with at least 12 distinct proteins, including several members of the NuRD and Sin3A repression complexes, and appear to define a new but related complex. ..
  2. Gupta P, Ho P, Ha S, Lin Y, Wei L. HDAC3 as a molecular chaperone for shuttling phosphorylated TR2 to PML: a novel deacetylase activity-independent function of HDAC3. PLoS ONE. 2009;4:e4363 pubmed publisher
    ..First, we identify histone deacetylase 3 (HDAC3) as an effector molecule. HDAC3 is known to interact with TR2 (Franco et al...
  3. Zhang C, McKinsey T, Lu J, Olson E. Association of COOH-terminal-binding protein (CtBP) and MEF2-interacting transcription repressor (MITR) contributes to transcriptional repression of the MEF2 transcription factor. J Biol Chem. 2001;276:35-9 pubmed
    ..These findings reveal CtBP-dependent and -independent mechanisms for transcriptional repression by MITR and show that MITR represses MEF2 activity through recruitment of multicomponent corepressor complexes that include CtBP and HDACs. ..
  4. Trivedi C, Luo Y, Yin Z, Zhang M, Zhu W, Wang T, et al. Hdac2 regulates the cardiac hypertrophic response by modulating Gsk3 beta activity. Nat Med. 2007;13:324-31 pubmed
  5. Sun Z, Singh N, Mullican S, Everett L, Li L, Yuan L, et al. Diet-induced lethality due to deletion of the Hdac3 gene in heart and skeletal muscle. J Biol Chem. 2011;286:33301-9 pubmed publisher
    ..Here, we report a novel and dramatic influence of diet on the phenotype and survival of mice in which histone deacetylase 3 (Hdac3) is deleted postnatally in heart and skeletal muscle...
  6. McQuown S, Barrett R, Matheos D, Post R, ROGGE G, Alenghat T, et al. HDAC3 is a critical negative regulator of long-term memory formation. J Neurosci. 2011;31:764-74 pubmed publisher
    ..We examined the role of HDAC3 in long-term memory using a combined genetic and pharmacologic approach...
  7. Bardai F, Price V, Zaayman M, Wang L, D Mello S. Histone deacetylase-1 (HDAC1) is a molecular switch between neuronal survival and death. J Biol Chem. 2012;287:35444-53 pubmed publisher
    ..The neurotoxic effect of HDAC1 requires interaction and cooperation with HDAC3, which has previously been shown to selectively induce the death of neurons...
  8. Tussie Luna M, Bayarsaihan D, Seto E, Ruddle F, Roy A. Physical and functional interactions of histone deacetylase 3 with TFII-I family proteins and PIASxbeta. Proc Natl Acad Sci U S A. 2002;99:12807-12 pubmed
    ..Here, we show that TFII-I and its related member hMusTRD1/BEN physically and functionally interact with HDAC3. The TFII-I family proteins and HDAC3 also show nearly identical expression patterns in early mouse development...
  9. Mullican S, Gaddis C, Alenghat T, Nair M, Giacomin P, Everett L, et al. Histone deacetylase 3 is an epigenomic brake in macrophage alternative activation. Genes Dev. 2011;25:2480-8 pubmed publisher
    ..Here we report that macrophages lacking histone deacetylase 3 (HDAC3) display a polarization phenotype similar to IL-4-induced alternative activation and, furthermore, ..

More Information


  1. Bhaskara S, Knutson S, Jiang G, Chandrasekharan M, Wilson A, Zheng S, et al. Hdac3 is essential for the maintenance of chromatin structure and genome stability. Cancer Cell. 2010;18:436-47 pubmed publisher
    b>Hdac3 is essential for efficient DNA replication and DNA damage control. Deletion of Hdac3 impaired DNA repair and greatly reduced chromatin compaction and heterochromatin content...
  2. Razidlo D, Whitney T, Casper M, McGee Lawrence M, Stensgard B, Li X, et al. Histone deacetylase 3 depletion in osteo/chondroprogenitor cells decreases bone density and increases marrow fat. PLoS ONE. 2010;5:e11492 pubmed publisher
    ..To determine the role of Hdac3 in bone formation, we crossed mice harboring loxP sites around exon 7 of Hdac3 with mice expressing Cre ..
  3. Witt O, Deubzer H, Milde T, Oehme I. HDAC family: What are the cancer relevant targets?. Cancer Lett. 2009;277:8-21 pubmed publisher
    ..The aim of this review is to discuss individual HDAC family members as drug targets in cancer taking into consideration their function under physiological conditions and their oncogenic potential in malignant disease. ..
  4. Lagger G, O Carroll D, Rembold M, Khier H, Tischler J, Weitzer G, et al. Essential function of histone deacetylase 1 in proliferation control and CDK inhibitor repression. EMBO J. 2002;21:2672-81 pubmed
    ..The expression of HDAC2 and HDAC3 is induced in HDAC1-deficient cells, but cannot compensate for loss of the enzyme, suggesting a unique function ..
  5. Feng D, Liu T, Sun Z, Bugge A, Mullican S, Alenghat T, et al. A circadian rhythm orchestrated by histone deacetylase 3 controls hepatic lipid metabolism. Science. 2011;331:1315-9 pubmed publisher
    ..We show that histone deacetylase 3 (HDAC3) recruitment to the genome displays a circadian rhythm in mouse liver...
  6. You S, Liao X, Weiss R, Lazar M. The interaction between nuclear receptor corepressor and histone deacetylase 3 regulates both positive and negative thyroid hormone action in vivo. Mol Endocrinol. 2010;24:1359-67 pubmed publisher
    ..TH-activated by recruiting the nuclear receptor corepressor (NCoR), which exists in a tight complex with histone deacetylase 3 (HDAC3)...
  7. Vega R, Matsuda K, Oh J, Barbosa A, Yang X, Meadows E, et al. Histone deacetylase 4 controls chondrocyte hypertrophy during skeletogenesis. Cell. 2004;119:555-66 pubmed
    ..These results establish HDAC4 as a central regulator of chondrocyte hypertrophy and skeletogenesis and suggest general roles for class II HDACs in the control of cellular hypertrophy. ..
  8. Ishizuka T, Lazar M. The nuclear receptor corepressor deacetylase activating domain is essential for repression by thyroid hormone receptor. Mol Endocrinol. 2005;19:1443-51 pubmed
    ..By contrast, deletion of the deacetylase activating domain (DAD) that binds and activates histone deacetylase 3 dramatically hampered N-CoR's function as a TR corepressor...
  9. Moumné L, Campbell K, Howland D, Ouyang Y, Bates G. Genetic knock-down of HDAC3 does not modify disease-related phenotypes in a mouse model of Huntington's disease. PLoS ONE. 2012;7:e31080 pubmed publisher
    ..The study presented here focuses on HDAC3, which, as a class I HDAC, is one of the preferred targets of SAHA and is directly involved in histone ..
  10. Ma P, Schultz R. Histone deacetylase 1 (HDAC1) regulates histone acetylation, development, and gene expression in preimplantation mouse embryos. Dev Biol. 2008;319:110-20 pubmed publisher
    ..In this study, we investigated expression and function of Class I histone deacetylases (HDAC) HDAC1, HDAC2, and HDAC3 during preimplantation development...
  11. Chang S, Young B, Li S, Qi X, Richardson J, Olson E. Histone deacetylase 7 maintains vascular integrity by repressing matrix metalloproteinase 10. Cell. 2006;126:321-34 pubmed
  12. Verdin E, Dequiedt F, Kasler H. Class II histone deacetylases: versatile regulators. Trends Genet. 2003;19:286-93 pubmed
    ..We discuss their emerging biological functions and the molecular mechanisms by which they are regulated. ..
  13. Sun Z, Miller R, Patel R, Chen J, Dhir R, Wang H, et al. Hepatic Hdac3 promotes gluconeogenesis by repressing lipid synthesis and sequestration. Nat Med. 2012;18:934-42 pubmed publisher
    ..b>Histone deacetylase 3 (Hdac3) controls the circadian rhythm of hepatic lipogenesis...
  14. Bardai F, Verma P, Smith C, Rawat V, Wang L, D Mello S. Disassociation of histone deacetylase-3 from normal huntingtin underlies mutant huntingtin neurotoxicity. J Neurosci. 2013;33:11833-8 pubmed publisher
    ..Neuroprotection by Htt is mediated by its sequestration of histone deacetylase-3 (HDAC3), a protein known to promote neuronal death. In contrast to the normal Htt, mutant Htt interacts poorly with HDAC3...
  15. Schroeder T, Kahler R, Li X, Westendorf J. Histone deacetylase 3 interacts with runx2 to repress the osteocalcin promoter and regulate osteoblast differentiation. J Biol Chem. 2004;279:41998-2007 pubmed
    ..In transient transfection assays, HDAC3 repressed Runx2-mediated activation of the osteocalcin promoter...
  16. Wolter S, Doerrie A, Weber A, Schneider H, Hoffmann E, von der Ohe J, et al. c-Jun controls histone modifications, NF-kappaB recruitment, and RNA polymerase II function to activate the ccl2 gene. Mol Cell Biol. 2008;28:4407-23 pubmed publisher
    ..c-Jun regulates Ser10 phosphorylation of histone H3, acetylation of histones H3 and H4, and recruitment of histone deacetylase 3 (HDAC3), NF-kappaB subunits, and RNA polymerase II across the ccl2 locus...
  17. Montgomery R, Potthoff M, Haberland M, Qi X, Matsuzaki S, Humphries K, et al. Maintenance of cardiac energy metabolism by histone deacetylase 3 in mice. J Clin Invest. 2008;118:3588-97 pubmed publisher
    ..To explore the role of Hdac3 in the heart, we generated mice with a conditional Hdac3 null allele...
  18. Gregoire S, Xiao L, Nie J, Zhang X, Xu M, Li J, et al. Histone deacetylase 3 interacts with and deacetylates myocyte enhancer factor 2. Mol Cell Biol. 2007;27:1280-95 pubmed
    ..In contrast, HDAC3 efficiently deacetylated MEF2D in vitro and in vivo...
  19. Demmerle J, Koch A, Holaska J. The nuclear envelope protein emerin binds directly to histone deacetylase 3 (HDAC3) and activates HDAC3 activity. J Biol Chem. 2012;287:22080-8 pubmed publisher
    ..Here we show that emerin binds directly to HDAC3, the catalytic subunit of the nuclear co-repressor (NCoR) complex, and recruits HDAC3 to the nuclear periphery...
  20. Duncan C, An M, Papanikolaou T, Rugani C, Vitelli C, Ellerby L. Histone deacetylase-3 interacts with ataxin-7 and is altered in a spinocerebellar ataxia type 7 mouse model. Mol Neurodegener. 2013;8:42 pubmed publisher
    ..Interestingly, when we coexpressed each HDAC family member in the presence of ataxin-7 we found that HDAC3 increased the posttranslational modification of normal and expanded ataxin-7...
  21. Knutson S, Chyla B, Amann J, Bhaskara S, Huppert S, Hiebert S. Liver-specific deletion of histone deacetylase 3 disrupts metabolic transcriptional networks. EMBO J. 2008;27:1017-28 pubmed publisher
    b>Histone deacetylase 3 (Hdac3) is an enzymatic component of transcriptional repression complexes recruited by the nuclear hormone receptors...
  22. Chen X, Barozzi I, Termanini A, Prosperini E, Recchiuti A, Dalli J, et al. Requirement for the histone deacetylase Hdac3 for the inflammatory gene expression program in macrophages. Proc Natl Acad Sci U S A. 2012;109:E2865-74 pubmed publisher
    ..Using an integrated genomic approach, we found that Hdac3-deficient macrophages were unable to activate almost half of the inflammatory gene expression program when ..
  23. Demmerle J, Koch A, Holaska J. Emerin and histone deacetylase 3 (HDAC3) cooperatively regulate expression and nuclear positions of MyoD, Myf5, and Pax7 genes during myogenesis. Chromosome Res. 2013;21:765-79 pubmed publisher
    ..of Myf5, MyoD, and Pax7 to the nuclear lamina and proper temporal expression of these genes required emerin and HDAC3. Interestingly, activation of HDAC3 catalytic activity rescued both Myf5 localization to the nuclear lamina and ..
  24. Zampetaki A, Zeng L, Margariti A, Xiao Q, Li H, Zhang Z, et al. Histone deacetylase 3 is critical in endothelial survival and atherosclerosis development in response to disturbed flow. Circulation. 2010;121:132-42 pubmed publisher
    b>Histone deacetylase 3 (HDAC3) is known to play a crucial role in the differentiation of endothelial progenitors. The role of HDAC3 in mature endothelial cells, however, is not well understood...
  25. Alenghat T, Meyers K, Mullican S, Leitner K, Adeniji Adele A, Avila J, et al. Nuclear receptor corepressor and histone deacetylase 3 govern circadian metabolic physiology. Nature. 2008;456:997-1000 pubmed publisher
    ..receptor corepressor 1 (Ncor1) functions as an activating subunit for the chromatin modifying enzyme histone deacetylase 3 (Hdac3)...
  26. Bhaskara S, Chyla B, Amann J, Knutson S, Cortez D, Sun Z, et al. Deletion of histone deacetylase 3 reveals critical roles in S phase progression and DNA damage control. Mol Cell. 2008;30:61-72 pubmed publisher
    ..To understand the function of Hdac3, a critical component of the N-CoR/SMRT repression complex, a conditional allele of Hdac3 was engineered...
  27. Pelzel H, Schlamp C, Waclawski M, Shaw M, Nickells R. Silencing of Fem1cR3 gene expression in the DBA/2J mouse precedes retinal ganglion cell death and is associated with histone deacetylase activity. Invest Ophthalmol Vis Sci. 2012;53:1428-35 pubmed publisher
    ..The localization of histone deacetylase 3 (HDAC3) and nuclear histone H4 acetylation were examined by immunofluorescence in dying cells...
  28. Chang S, McKinsey T, Zhang C, Richardson J, Hill J, Olson E. Histone deacetylases 5 and 9 govern responsiveness of the heart to a subset of stress signals and play redundant roles in heart development. Mol Cell Biol. 2004;24:8467-76 pubmed
    ..These findings reveal central roles for HDACs 5 and 9 in the suppression of a subset of cardiac stress signals as well as redundant functions in the control of cardiac development. ..
  29. Vecera J, Bartova E, Krejci J, Legartova S, Komůrková D, Ruda Kucerova J, et al. HDAC1 and HDAC3 underlie dynamic H3K9 acetylation during embryonic neurogenesis and in schizophrenia-like animals. J Cell Physiol. 2018;233:530-548 pubmed publisher
    ..brain (E15) is characterized by an increase in H3K9 acetylation as well as decreases in the levels of HDAC1 and HDAC3. Moreover, experimental induction of H3K9 hyperacetylation led to the overexpression of NCAM in the embryonic ..
  30. Li X, Kato Y, Tsuji Y, Tsunoda Y. The effects of trichostatin A on mRNA expression of chromatin structure-, DNA methylation-, and development-related genes in cloned mouse blastocysts. Cloning Stem Cells. 2008;10:133-42 pubmed publisher
    ..Such modifications might be a reason for the high developmental potential of mouse SCNT oocytes treated with TSA. ..
  31. Kirpich I, Zhang J, Gobejishvili L, Kharebava G, Barker D, Ghare S, et al. Binge ethanol-induced HDAC3 down-regulates Cpt1? expression leading to hepatic steatosis and injury. Alcohol Clin Exp Res. 2013;37:1920-9 pubmed publisher
    ..Various class I, II, and IV HDACs were down-regulated, whereas expression of HDAC3 was solely up-regulated...
  32. Sun G, Yu R, Evans R, Shi Y. Orphan nuclear receptor TLX recruits histone deacetylases to repress transcription and regulate neural stem cell proliferation. Proc Natl Acad Sci U S A. 2007;104:15282-7 pubmed
    ..TLX interacts with HDAC3 and HDAC5 in neural stem cells...
  33. ROGGE G, Singh H, Dang R, Wood M. HDAC3 is a negative regulator of cocaine-context-associated memory formation. J Neurosci. 2013;33:6623-32 pubmed publisher
    ..HDAC4 and HDAC5 are known to interact with HDAC3, but the role of HDAC3 in cocaine-induced behaviors has never been examined...
  34. Schmitt H, Pelzel H, Schlamp C, Nickells R. Histone deacetylase 3 (HDAC3) plays an important role in retinal ganglion cell death after acute optic nerve injury. Mol Neurodegener. 2014;9:39 pubmed publisher
    ..Importantly, these neurons exhibit nuclear translocation of HDAC3 shortly after optic nerve damage...
  35. McGee Lawrence M, Bradley E, Dudakovic A, Carlson S, Ryan Z, Kumar R, et al. Histone deacetylase 3 is required for maintenance of bone mass during aging. Bone. 2013;52:296-307 pubmed publisher
    b>Histone deacetylase 3 (Hdac3) is a nuclear enzyme that removes acetyl groups from lysine residues in histones and other proteins to epigenetically regulate gene expression...
  36. Ferreira R, Popova E, James J, Briones M, Zhang S, Barnstable C. Histone Deacetylase 1 Is Essential for Rod Photoreceptor Differentiation by Regulating Acetylation at Histone H3 Lysine 9 and Histone H4 Lysine 12 in the Mouse Retina. J Biol Chem. 2017;292:2422-2440 pubmed publisher
    ..HDAC1 may be an essential epigenetic regulator of the transition from progenitor cells to terminally differentiated photoreceptors. ..
  37. Dirice E, Ng R, Martinez R, Hu J, Wagner F, Holson E, et al. Isoform-selective inhibitor of histone deacetylase 3 (HDAC3) limits pancreatic islet infiltration and protects female nonobese diabetic mice from diabetes. J Biol Chem. 2017;292:17598-17608 pubmed publisher
    ..of HDAC inhibitors (HDACi) in vivo We show that daily administration of BRD3308, an isoform-selective HDAC3 inhibitor, for 2 weeks to female nonobese diabetic (NOD) mice, beginning at 3 weeks of age, followed by twice-..
  38. Chen Y, Zang X, Pan J, Zhu X, Chen F, Chen Z, et al. Expression patterns of histone deacetylases in experimental stroke and potential targets for neuroprotection. Clin Exp Pharmacol Physiol. 2012;39:751-8 pubmed publisher
    ..Notably, there was a substantial increase in HDAC3, HDAC6 and HDAC11 expression during the early phases of experimental stroke, indicating their contribution to ..
  39. Segev H, Memili E, First N. Expression patterns of histone deacetylases in bovine oocytes and early embryos, and the effect of their inhibition on embryo development. Zygote. 2001;9:123-33 pubmed
    ..RPD3, a yeast global regulator of transcription, was also detected in bovine oocytes and embryos. Results suggest that HDACs may be operative in regulation of zygotic/embryonic gene expression in cattle. ..
  40. Jin C, Li H, Murata T, Sun K, Horikoshi M, Chiu R, et al. JDP2, a repressor of AP-1, recruits a histone deacetylase 3 complex to inhibit the retinoic acid-induced differentiation of F9 cells. Mol Cell Biol. 2002;22:4815-26 pubmed
    ..repressor of AP-1, inhibits the transactivation of the c-jun gene by ATF-2 and p300 by recruitment of the histone deacetylase 3 (HDAC3) complex, thereby repressing the RA-induced transcription of the c-jun gene and inhibiting the RA-..
  41. Shi G, Xie P, Qu Z, Zhang Z, Dong Z, An Y, et al. Distinct Roles of HDAC3 in the Core Circadian Negative Feedback Loop Are Critical for Clock Function. Cell Rep. 2016;14:823-834 pubmed publisher
    ..These two processes are separated temporally to ensure clock function. Here, we show that histone deacetylase 3 (HDAC3) is a critical component of the circadian negative feedback loop by regulating both the activation ..
  42. Jeon B, Kim M, Choi W, Koh D, Hong S, Kim K, et al. KR-POK interacts with p53 and represses its ability to activate transcription of p21WAF1/CDKN1A. Cancer Res. 2012;72:1137-48 pubmed publisher
    ..Together, our findings define KR-POK as a transcriptional repressor with a pro-oncogenic role that relies upon binding to p53 and inhibition of its transactivation function. ..
  43. Hartman H, Yu J, Alenghat T, Ishizuka T, Lazar M. The histone-binding code of nuclear receptor co-repressors matches the substrate specificity of histone deacetylase 3. EMBO Rep. 2005;6:445-51 pubmed
    ..As expected, repression is characterized by recruitment of N-CoR/SMRT-HDAC3 (histone deacetylase 3) co-repressor complexes, leading to local histone hypoacetylation...
  44. Stengel K, Zhao Y, Klus N, Kaiser J, Gordy L, Joyce S, et al. Histone Deacetylase 3 Is Required for Efficient T Cell Development. Mol Cell Biol. 2015;35:3854-65 pubmed publisher
    b>Hdac3 is a key target for Hdac inhibitors that are efficacious in cutaneous T cell lymphoma...
  45. Samant S, Pillai V, Sundaresan N, Shroff S, Gupta M. Histone Deacetylase 3 (HDAC3)-dependent Reversible Lysine Acetylation of Cardiac Myosin Heavy Chain Isoforms Modulates Their Enzymatic and Motor Activity. J Biol Chem. 2015;290:15559-69 pubmed publisher
    ..In this study we show that a class I HDAC, HDAC3, is also present at cardiac sarcomeres...
  46. Greene T, Tokuyama M, Knudsen G, Kunz M, Lin J, Greninger A, et al. A Herpesviral induction of RAE-1 NKG2D ligand expression occurs through release of HDAC mediated repression. elife. 2016;5: pubmed publisher
    ..We demonstrate that RAE-1 is transcriptionally repressed by histone deacetylase inhibitor 3 (HDAC3) in healthy cells, and m18 relieves this repression by directly interacting with Casein Kinase II and preventing ..
  47. Perissi V, Aggarwal A, Glass C, Rose D, Rosenfeld M. A corepressor/coactivator exchange complex required for transcriptional activation by nuclear receptors and other regulated transcription factors. Cell. 2004;116:511-26 pubmed
    ..The role of TBLR1 and TBL1 in cofactor exchange appears to also operate for c-Jun and NFkappaB and is therefore likely to be prototypic of similar mechanisms for other signal-dependent transcription factors. ..
  48. Zhao H, Ueki N, Marcelain K, Hayman M. The Ski protein can inhibit ligand induced RARalpha and HDAC3 degradation in the retinoic acid signaling pathway. Biochem Biophys Res Commun. 2009;383:119-24 pubmed publisher
    ..We determined that Ski can stabilize RARalpha and HDAC3. These results suggest that Ski represses RA signaling by stabilizing corepressor complex.
  49. Song P, Zhou Y, Coughlan K, Dai X, Xu H, Viollet B, et al. Adenosine monophosphate-activated protein kinase-?2 deficiency promotes vascular smooth muscle cell migration via S-phase kinase-associated protein 2 upregulation and E-cadherin downregulation. Arterioscler Thromb Vasc Biol. 2013;33:2800-9 pubmed publisher
    ..Finally, neointima formation after ligation of carotid artery was increased in AMPK?2(-/-), but not AMPK?1(-/-), mice. We conclude that deletion of AMPK?2 causes aberrant VSMC migration with accelerated neointima formation in vivo. ..
  50. Armour S, Remsberg J, Damle M, Sidoli S, Ho W, Li Z, et al. An HDAC3-PROX1 corepressor module acts on HNF4? to control hepatic triglycerides. Nat Commun. 2017;8:549 pubmed publisher
    The histone deacetylase HDAC3 is a critical mediator of hepatic lipid metabolism, and liver-specific deletion of HDAC3 leads to fatty liver...
  51. Jain N, Iyer K, Kumar A, Shivashankar G. Cell geometric constraints induce modular gene-expression patterns via redistribution of HDAC3 regulated by actomyosin contractility. Proc Natl Acad Sci U S A. 2013;110:11349-54 pubmed publisher
    ..Interestingly, cytoplasmic-to-nuclear redistribution of histone deacetylase 3 modulated histone acetylation in an actomyosin-dependent manner...
  52. Nanou A, Toumpeki C, Lavigne M, Lazou V, Demmers J, Paparountas T, et al. The dual role of LSD1 and HDAC3 in STAT5-dependent transcription is determined by protein interactions, binding affinities, motifs and genomic positions. Nucleic Acids Res. 2017;45:142-154 pubmed publisher
    ..Here, LSD1 and HDAC3 were identified as novel STAT5a interacting partners in pro-B cells...
  53. Murko C, Lagger S, Steiner M, Seiser C, Schoefer C, Pusch O. Expression of class I histone deacetylases during chick and mouse development. Int J Dev Biol. 2010;54:1527-37 pubmed publisher
    ..Our results present a basis for further functional analysis of class I HDACs in chick development. ..
  54. Cao D, Wang Z, Zhang C, Oh J, Xing W, Li S, et al. Modulation of smooth muscle gene expression by association of histone acetyltransferases and deacetylases with myocardin. Mol Cell Biol. 2005;25:364-76 pubmed
    ..These findings point to myocardin as a nexus for positive and negative regulation of smooth muscle gene expression by changes in chromatin acetylation. ..
  55. Amann J, Chyla B, Ellis T, Martinez A, Moore A, Franklin J, et al. Mtgr1 is a transcriptional corepressor that is required for maintenance of the secretory cell lineage in the small intestine. Mol Cell Biol. 2005;25:9576-85 pubmed
    ..We demonstrate that Mtgr1 associates with mSin3A, N-CoR, and histone deacetylase 3 and that when tethered to DNA, Mtgr1 represses transcription, suggesting that Mtgr1 also acts as a ..
  56. Choo M, Yeo H, Zayzafoon M. NFATc1 mediates HDAC-dependent transcriptional repression of osteocalcin expression during osteoblast differentiation. Bone. 2009;45:579-89 pubmed publisher
    ..we show by Chromatin Immunoprecipitation (ChIP) assay that the overexpression of NFATc1 sustains the binding of HDAC3 on the proximal region of the osteocalcin promoter, resulting in complete hypoacetylation of histones H3 and H4 ..
  57. Mahlknecht U, Bucala R, Verdin E. Assignment of the histone deacetylase gene (Hdac3) to mouse chromosome 18B3 by in situ hybridization. Cytogenet Cell Genet. 1999;84:192-3 pubmed
  58. Norwood J, Franklin J, Sharma D, D Mello S. Histone deacetylase 3 is necessary for proper brain development. J Biol Chem. 2014;289:34569-82 pubmed publisher
    The functional role of histone deacetylase 3 (HDAC3) in the developing brain has yet to be elucidated...
  59. Risebro C, Petchey L, Smart N, Gomes J, Clark J, Vieira J, et al. Epistatic rescue of Nkx2.5 adult cardiac conduction disease phenotypes by prospero-related homeobox protein 1 and HDAC3. Circ Res. 2012;111:e19-31 pubmed publisher
    ..with both gain and loss-of-function reporter assays in vitro, revealed that Prox1 recruits the corepressor HDAC3 to directly repress Nkx2.5 via a proximal upstream enhancer as a mechanism for regulating Nkx2...
  60. Nott A, Cheng J, Gao F, Lin Y, Gjoneska E, Ko T, et al. Histone deacetylase 3 associates with MeCP2 to regulate FOXO and social behavior. Nat Neurosci. 2016;19:1497-1505 pubmed publisher
    ..The RTT missense MECP2R306C mutation prevents MeCP2 from interacting with the NCoR/histone deacetylase 3 (HDAC3) complex; however, the neuronal function of HDAC3 is incompletely understood...
  61. Kim Y, Kim K, Park D, Lee E, Lee H, Lee Y, et al. Histone deacetylase 3 mediates allergic skin inflammation by regulating expression of MCP1 protein. J Biol Chem. 2012;287:25844-59 pubmed publisher
    We have shown the induction of histone deacetylase 3 (HDAC3) in antigen-stimulated rat basophilic leukemia cells via NF-?B. We investigated the role of HDAC3 in allergic skin inflammation...
  62. Hua G, Paulen L, Chambon P. GR SUMOylation and formation of an SUMO-SMRT/NCoR1-HDAC3 repressing complex is mandatory for GC-induced IR nGRE-mediated transrepression. Proc Natl Acad Sci U S A. 2016;113:E626-34 pubmed publisher
    ..In mice selectively ablated for histone deacetylase 3 (HDAC3) in skin keratinocytes, GC-induced direct repression, but not bindings of GR and of corepressors ..
  63. Ferrari A, Longo R, Fiorino E, Silva R, Mitro N, Cermenati G, et al. HDAC3 is a molecular brake of the metabolic switch supporting white adipose tissue browning. Nat Commun. 2017;8:93 pubmed publisher
    ..Here we show that histone deacetylase 3 (HDAC3) regulates WAT metabolism and function...
  64. Kaltezioti V, Kouroupi G, Oikonomaki M, Mantouvalou E, Stergiopoulos A, Charonis A, et al. Prox1 regulates the notch1-mediated inhibition of neurogenesis. PLoS Biol. 2010;8:e1000565 pubmed publisher
    ..Together these data suggest that Prox1 inhibits Notch1 gene expression to control the balance between NPC self-renewal and neuronal differentiation. ..
  65. Goodwin M, Molleston J, Canny S, Abou El Hassan M, Willert E, Bremner R, et al. Histone deacetylases and the nuclear receptor corepressor regulate lytic-latent switch gene 50 in murine gammaherpesvirus 68-infected macrophages. J Virol. 2010;84:12039-47 pubmed publisher
    ..The HDAC inhibitor trichostatin A (TSA) acts on the gene 50 promoter to induce lytic replication of MHV68. HDAC3, HDAC4, and the nuclear receptor corepressor (NCoR) are required for efficient silencing of gene 50 expression...
  66. He Q, Gao Z, Yin J, Zhang J, Yun Z, Ye J. Regulation of HIF-1{alpha} activity in adipose tissue by obesity-associated factors: adipogenesis, insulin, and hypoxia. Am J Physiol Endocrinol Metab. 2011;300:E877-85 pubmed publisher
    ..hypoxia response element in the VEGF gene promoter, and its function is inhibited by a corepressor composed of HDAC3 and SMRT...
  67. Navabi N, Whitt J, Wu S, Woo V, Moncivaiz J, Jordan M, et al. Epithelial Histone Deacetylase 3 Instructs Intestinal Immunity by Coordinating Local Lymphocyte Activation. Cell Rep. 2017;19:1165-1175 pubmed publisher
    ..Here, we show an essential role for intestinal epithelial cell expression of histone deacetylase 3 (HDAC3) in responding to pathogenic microbes and activating protective innate immunity...
  68. Emmett M, Lim H, Jager J, Richter H, Adlanmerini M, Peed L, et al. Histone deacetylase 3 prepares brown adipose tissue for acute thermogenic challenge. Nature. 2017;546:544-548 pubmed publisher
    ..Here we show that histone deacetylase 3 (HDAC3) is required to activate brown adipose tissue enhancers to ensure thermogenic aptitude...
  69. Zhang J, Henagan T, Gao Z, Ye J. Inhibition of glyceroneogenesis by histone deacetylase 3 contributes to lipodystrophy in mice with adipose tissue inflammation. Endocrinology. 2011;152:1829-38 pubmed publisher
    ..Pepck gene promoter is inhibited by NF-?B, which enhances the corepressor activity through activation of histone deacetylase 3 (HDAC3) in the nucleus...
  70. Guan H, Ishizuka T, Chui P, Lehrke M, Lazar M. Corepressors selectively control the transcriptional activity of PPARgamma in adipocytes. Genes Dev. 2005;19:453-61 pubmed
    ..Thus, selective modulation of adipocyte PPARgamma target genes by TZDs involves the dissociation of corepressors by direct and indirect mechanisms. ..