Gene Symbol: Hdac11
Description: histone deacetylase 11
Alias: histone deacetylase 11, HD11
Species: mouse
Products:     Hdac11

Top Publications

  1. Liu H, Hu Q, Kaufman A, D Ercole A, Ye P. Developmental expression of histone deacetylase 11 in the murine brain. J Neurosci Res. 2008;86:537-43 pubmed
    ..To begin to understand these mechanisms, we investigated the expression of histone deacetylase 11 (HDAC11), a newly identified HDAC, in mouse brain during postnatal development...
  2. Bryant D, Landles C, Papadopoulou A, Benjamin A, Duckworth J, Rosahl T, et al. Disruption to schizophrenia-associated gene Fez1 in the hippocampus of HDAC11 knockout mice. Sci Rep. 2017;7:11900 pubmed publisher
    b>Histone Deacetylase 11 (HDAC11) is highly expressed in the central nervous system where it has been reported to have roles in neural differentiation...
  3. Villagra A, Cheng F, Wang H, Suarez I, Glozak M, Maurin M, et al. The histone deacetylase HDAC11 regulates the expression of interleukin 10 and immune tolerance. Nat Immunol. 2009;10:92-100 pubmed publisher
    ..The molecular basis of the regulation of this critical 'decision' is not well understood. Here we show that HDAC11, a member of the HDAC histone deacetylase family with no prior defined physiological function, negatively ..
  4. Watanabe Y, Khodosevich K, Monyer H. Dendrite development regulated by the schizophrenia-associated gene FEZ1 involves the ubiquitin proteasome system. Cell Rep. 2014;7:552-64 pubmed publisher
    ..The modulatory function of BubR1 is dependent on its acetylation status. We show that BubR1 is deacetylated by Hdac11, thereby disinhibiting the Cdc20/APC complex...
  5. Bala S, Csak T, Kodys K, Catalano D, Ambade A, Fűri I, et al. Alcohol-induced miR-155 and HDAC11 inhibit negative regulators of the TLR4 pathway and lead to increased LPS responsiveness of Kupffer cells in alcoholic liver disease. J Leukoc Biol. 2017;102:487-498 pubmed publisher
    ..b>HDAC11, a regulator of IL-10, was significantly increased and IL-10 was decreased in KCs that were isolated from alcohol-..
  6. Cheng F, Lienlaf M, Perez Villarroel P, Wang H, Lee C, Woan K, et al. Divergent roles of histone deacetylase 6 (HDAC6) and histone deacetylase 11 (HDAC11) on the transcriptional regulation of IL10 in antigen presenting cells. Mol Immunol. 2014;60:44-53 pubmed publisher
    ..described as negative regulators of transcriptional regulation, and in this context, the primarily nuclear protein HDAC11 was shown to repress il-10 gene transcriptional activity in antigen-presenting cells (APCs)...
  7. Tiwari S, Dharmarajan S, Shivanna M, Otteson D, Belecky Adams T. Histone deacetylase expression patterns in developing murine optic nerve. BMC Dev Biol. 2014;14:30 pubmed publisher
    ..These HDACs are candidates for further research to understand how chromatin remodeling through acetylation, deacetylation and methylation contributes to glial development as well as their injury response. ..
  8. Sahakian E, Powers J, Chen J, Deng S, Cheng F, Distler A, et al. Histone deacetylase 11: A novel epigenetic regulator of myeloid derived suppressor cell expansion and function. Mol Immunol. 2015;63:579-85 pubmed publisher
    ..b>HDAC11 has emerged as a key regulator of IL-10 gene expression in myeloid cells, suggesting that this may represent an ..
  9. Ferreira R, Popova E, James J, Briones M, Zhang S, Barnstable C. Histone Deacetylase 1 Is Essential for Rod Photoreceptor Differentiation by Regulating Acetylation at Histone H3 Lysine 9 and Histone H4 Lysine 12 in the Mouse Retina. J Biol Chem. 2017;292:2422-2440 pubmed publisher
    ..HDAC1 may be an essential epigenetic regulator of the transition from progenitor cells to terminally differentiated photoreceptors. ..

More Information


  1. Woods D, Woan K, Cheng F, Sodre A, Wang D, Wu Y, et al. T cells lacking HDAC11 have increased effector functions and mediate enhanced alloreactivity in a murine model. Blood. 2017;130:146-155 pubmed publisher
    ..Here, we demonstrate a previously undefined role of histone deacetylase 11 (HDAC11) in regulating T-cell effector functions...
  2. Sahakian E, Chen J, Powers J, Chen X, Maharaj K, Deng S, et al. Essential role for histone deacetylase 11 (HDAC11) in neutrophil biology. J Leukoc Biol. 2017;102:475-486 pubmed publisher
    ..b>HDAC11, the newest member of the HDAC family of enzymes, functions as a negative regulator of IL-10 expression in APCs, ..
  3. Izzi L, Silvestri C, Von Both I, Labbé E, Zakin L, Wrana J, et al. Foxh1 recruits Gsc to negatively regulate Mixl1 expression during early mouse development. EMBO J. 2007;26:3132-43 pubmed
    ..As Gsc is itself induced in a Foxh1-dependent manner, we propose that Foxh1 initiates positive and negative transcriptional circuits to refine cell fate decisions during gastrulation. ..
  4. Pang A, Taylor H, Johnson W, Alexander S, Chen Y, Su Y, et al. Identification of differentially expressed genes in mouse spermatogenesis. J Androl. 2003;24:899-911 pubmed
    ..Many of the genes identified were not previously characterized. This study highlights new targets for manipulation to unravel the molecular mechanism of spermatogenesis. ..
  5. Bagui T, Sharma S, Ma L, Pledger W. Proliferative status regulates HDAC11 mRNA abundance in nontransformed fibroblasts. Cell Cycle. 2013;12:3433-41 pubmed publisher
    Histone deacetylases (HDACs) are important determinants of gene transcription and other biological processes. HDAC11 is one of the least characterized HDACs and is the only member of the class IV HDAC family...
  6. Verdin E, Dequiedt F, Kasler H. Class II histone deacetylases: versatile regulators. Trends Genet. 2003;19:286-93 pubmed
    ..We discuss their emerging biological functions and the molecular mechanisms by which they are regulated. ..
  7. Witt O, Deubzer H, Milde T, Oehme I. HDAC family: What are the cancer relevant targets?. Cancer Lett. 2009;277:8-21 pubmed publisher
    ..The aim of this review is to discuss individual HDAC family members as drug targets in cancer taking into consideration their function under physiological conditions and their oncogenic potential in malignant disease. ..
  8. Kim J, Jung K, Jang H, Park K. Gender-specific role of HDAC11 in kidney ischemia- and reperfusion-induced PAI-1 expression and injury. Am J Physiol Renal Physiol. 2013;305:F61-70 pubmed publisher
    ..PAI-1 inhibition protected the kidney from I/R-induced inflammation and functional loss. Among HDACs, only HDAC11 negatively regulated PAI-1 expression in I/R-subjected kidney gender specifically and lipopolysaccharide (LPS)-..