Gene Symbol: Hck
Description: hemopoietic cell kinase
Alias: AI849071, Bmk, tyrosine-protein kinase HCK, B cell/myeloid kinase, hematopoietic cell kinase, p56-HCK/p59-HCK
Species: mouse
Products:     Hck

Top Publications

  1. Ziegler S, Marth J, Lewis D, Perlmutter R. Novel protein-tyrosine kinase gene (hck) preferentially expressed in cells of hematopoietic origin. Mol Cell Biol. 1987;7:2276-85 pubmed
    ..Here we report the characterization of a novel human protein-tyrosine kinase gene (hck) that is primarily expressed in hematopoietic cells, particularly granulocytes...
  2. Reith A. Isolation and chromosomal location of Nsk1, a novel murine putative receptor tyrosine kinase. Mamm Genome. 1995;6:689 pubmed
  3. Crowley M, Costello P, Fitzer Attas C, Turner M, Meng F, Lowell C, et al. A critical role for Syk in signal transduction and phagocytosis mediated by Fcgamma receptors on macrophages. J Exp Med. 1997;186:1027-39 pubmed
    ..derived from mice deficient for the three members of the Src-family of kinases expressed in these cells, Hck, Fgr, and Lyn, exhibited poor Syk activation upon FcgammaR engagement, accompanied by a delay in FcgammaR-mediated ..
  4. Bae H, Gray J, Li M, Vines L, Kim J, Pestka J. Hematopoietic cell kinase associates with the 40S ribosomal subunit and mediates the ribotoxic stress response to deoxynivalenol in mononuclear phagocytes. Toxicol Sci. 2010;115:444-52 pubmed publisher
    ..macrophage-a response that is dependent on both double-stranded RNA-activated protein kinase (PKR) and hematopoietic cell kinase (Hck)...
  5. Suen P, Ilic D, Caveggion E, Berton G, Damsky C, Lowell C. Impaired integrin-mediated signal transduction, altered cytoskeletal structure and reduced motility in Hck/Fgr deficient macrophages. J Cell Sci. 1999;112 ( Pt 22):4067-78 pubmed
    ..kinases in integrin signal transduction, we have examined the adhesive properties of macrophages isolated from hck-/-fgr-/- double knockout mice which lack two of the three predominant Src-family kinases expressed in myeloid cells...
  6. Scholz G, Cartledge K, Dunn A. Hck enhances the adherence of lipopolysaccharide-stimulated macrophages via Cbl and phosphatidylinositol 3-kinase. J Biol Chem. 2000;275:14615-23 pubmed
    ..Immunoprecipitation experiments revealed that Cbl associates with Hck in Bac1.2F5 cells, while expression of an activated form of Hck in Bac1...
  7. Lowell C, Fumagalli L, Berton G. Deficiency of Src family kinases p59/61hck and p58c-fgr results in defective adhesion-dependent neutrophil functions. J Cell Biol. 1996;133:895-910 pubmed
    ..Src family kinases p59/61hck and p58c-fgr, we examined adhesion-dependent respiratory burst in PMNs isolated from hck -/-, fgr -/-, and hck -/- fgr -/- knockout mice...
  8. Jakus Z, Simon E, Frommhold D, Sperandio M, Mócsai A. Critical role of phospholipase Cgamma2 in integrin and Fc receptor-mediated neutrophil functions and the effector phase of autoimmune arthritis. J Exp Med. 2009;206:577-93 pubmed publisher
    ..These results identify PLCgamma2 as a critical player of integrin and Fc receptor-mediated neutrophil functions and the neutrophil-mediated effector phase of autoimmune arthritis. ..
  9. Mocsai A, Zhou M, Meng F, Tybulewicz V, Lowell C. Syk is required for integrin signaling in neutrophils. Immunity. 2002;16:547-58 pubmed
    ..Thus, integrins use different signaling mechanisms to support migration and adherent activation. ..

More Information


  1. Mocsai A, Abram C, Jakus Z, Hu Y, Lanier L, Lowell C. Integrin signaling in neutrophils and macrophages uses adaptors containing immunoreceptor tyrosine-based activation motifs. Nat Immunol. 2006;7:1326-33 pubmed
    ..Our data show that integrin signaling for the activation of cellular responses in neutrophils and macrophages proceeds by an immunoreceptor-like mechanism. ..
  2. Mocsai A, Ligeti E, Lowell C, Berton G. Adhesion-dependent degranulation of neutrophils requires the Src family kinases Fgr and Hck. J Immunol. 1999;162:1120-6 pubmed
    ..Double knockout hck-/- fgr-/- PMN adherent to collagen or fibrinogen failed to release lactoferrin in response to TNF-alpha but ..
  3. Zhang H, Meng F, Chu C, Takai T, Lowell C. The Src family kinases Hck and Fgr negatively regulate neutrophil and dendritic cell chemokine signaling via PIR-B. Immunity. 2005;22:235-46 pubmed
    ..However, neutrophils derived from hck-/-fgr-/- mice and dendritic cells (DCs) from fgr-/- animals manifested significantly higher intracellular signaling ..
  4. Lowell C, Soriano P, Varmus H. Functional overlap in the src gene family: inactivation of hck and fgr impairs natural immunity. Genes Dev. 1994;8:387-98 pubmed
    We have generated mice with targeted disruptions of the src-like genes hck and fgr to assess the role of these kinases in myeloid cell development and function...
  5. Vicentini L, Mazzi P, Caveggion E, Continolo S, Fumagalli L, Lapinet Vera J, et al. Fgr deficiency results in defective eosinophil recruitment to the lung during allergic airway inflammation. J Immunol. 2002;168:6446-54 pubmed
    ..tissue and airway eosinophilia were markedly reduced in fgr(-/-) mice, whereas mice with the sole deficiency of Hck, another Src family member, responded normally...
  6. Fitzer Attas C, Lowry M, Crowley M, Finn A, Meng F, DeFranco A, et al. Fcgamma receptor-mediated phagocytosis in macrophages lacking the Src family tyrosine kinases Hck, Fgr, and Lyn. J Exp Med. 2000;191:669-82 pubmed
    ..in bone marrow-derived macrophages from mutant mice lacking the major Src family kinases expressed in these cells, Hck, Fgr, and Lyn...
  7. Sarantos M, Zhang H, Schaff U, Dixit N, Hayenga H, Lowell C, et al. Transmigration of neutrophils across inflamed endothelium is signaled through LFA-1 and Src family kinase. J Immunol. 2008;181:8660-9 pubmed
    ..We conclude that dimeric bond clusters of LFA-1/ICAM-1 provide a key outside-in signal for orienting cytoskeletal dynamics that direct PMN extravasation at sites of inflammation. ..
  8. Lowell C, Niwa M, Soriano P, Varmus H. Deficiency of the Hck and Src tyrosine kinases results in extreme levels of extramedullary hematopoiesis. Blood. 1996;87:1780-92 pubmed
    Expression of the Src-family kinases--Src, Hck, and Fgr--increases dramatically during myeloid cell development...
  9. Xiao W, Hong H, Kawakami Y, Lowell C, Kawakami T. Regulation of myeloproliferation and M2 macrophage programming in mice by Lyn/Hck, SHIP, and Stat5. J Clin Invest. 2008;118:924-34 pubmed publisher
    ..we have shown that, similar to mice deficient in the lipid phosphatase SHIP, loss of 2 Src family kinases, Lyn and Hck, profoundly affects HSC differentiation, producing hematopoietic progenitors with increased proliferation, reduced ..
  10. Meng F, Lowell C. Lipopolysaccharide (LPS)-induced macrophage activation and signal transduction in the absence of Src-family kinases Hck, Fgr, and Lyn. J Exp Med. 1997;185:1661-70 pubmed
    ..Recently, an increasing amount of evidence suggests that protein tyrosine kinases especially the Src-family kinases Hck, Fgr, and Lyn, play important roles in LPS signaling...
  11. Giagulli C, Ottoboni L, Caveggion E, Rossi B, Lowell C, Constantin G, et al. The Src family kinases Hck and Fgr are dispensable for inside-out, chemoattractant-induced signaling regulating beta 2 integrin affinity and valency in neutrophils, but are required for beta 2 integrin-mediated outside-in signaling involved in sustai. J Immunol. 2006;177:604-11 pubmed
    ..Addressing inside-out and outside-in signaling in hck(-/-)fgr(-/-) neutrophils, we found that Hck and Fgr do not regulate chemoattractant-induced activation of beta(2) ..
  12. Fumagalli L, Zhang H, Baruzzi A, Lowell C, Berton G. The Src family kinases Hck and Fgr regulate neutrophil responses to N-formyl-methionyl-leucyl-phenylalanine. J Immunol. 2007;178:3874-85 pubmed
    ..Deficiency of the Src family kinases Hck and Fgr have previously been found to regulate fMLP-induced degranulation...
  13. Hirahashi J, Mekala D, Van Ziffle J, Xiao L, Saffaripour S, Wagner D, et al. Mac-1 signaling via Src-family and Syk kinases results in elastase-dependent thrombohemorrhagic vasculopathy. Immunity. 2006;25:271-83 pubmed
    ..complement C3 deposited within vessel walls and triggered a signaling pathway involving the Src-family kinase Hck and the Syk tyrosine kinase...
  14. Pereira S, Zhou M, Mocsai A, Lowell C. Resting murine neutrophils express functional alpha 4 integrins that signal through Src family kinases. J Immunol. 2001;166:4115-23 pubmed
    ..Neutrophils derived from hck(-/-)fgr(-/-)lyn(-/-) triple-knockout or hck(-/-)fgr(-/-) double-knockout mice failed to undergo respiratory burst ..
  15. Meng F, Lowell C. A beta 1 integrin signaling pathway involving Src-family kinases, Cbl and PI-3 kinase is required for macrophage spreading and migration. EMBO J. 1998;17:4391-403 pubmed
    ..In hck-/-fgr-/-lyn-/- triple mutant cells, which are defective in spreading on fibronectin-coated surfaces in vitro and ..
  16. Tai G, Hohenstein P, Davies J. FAK-Src signalling is important to renal collecting duct morphogenesis: discovery using a hierarchical screening technique. Biol Open. 2013;2:416-23 pubmed publisher
    ..We demonstrate the utility of the screen by using it to identify the FAK-Src-pathway signalling as being important for collecting duct development, specifically for the cell proliferation on which this development depends. ..
  17. Lee J, Lowell C, Lemay D, Youn H, Rhee S, Sohn K, et al. The regulation of the expression of inducible nitric oxide synthase by Src-family tyrosine kinases mediated through MyD88-independent signaling pathways of Toll-like receptor 4. Biochem Pharmacol. 2005;70:1231-40 pubmed
    ..nitric oxide synthase (iNOS) induced by LPS were not affected in macrophages deficient in three STKs (Lyn, Hck, and Fgr)...
  18. Huppi K, Siwarski D, Shaughnessy J, Klemsz M, Shirakata M, Maki R, et al. Genes associated with immunoglobulin V(D)J recombination are linked on mouse chromosome 2 and human chromosome 11. Immunogenetics. 1993;37:288-91 pubmed
  19. Calpe S, Erdos E, Liao G, Wang N, Rietdijk S, Simarro M, et al. Identification and characterization of two related murine genes, Eat2a and Eat2b, encoding single SH2-domain adapters. Immunogenetics. 2006;58:15-25 pubmed
    ..Both EAT-2A and EAT-2B bind to the Src-like kinases Fyn, Hck, Lyn, Lck, and Fgr, as determined by a yeast two-hybrid assay...
  20. Kamen L, Schlessinger J, Lowell C. Pyk2 is required for neutrophil degranulation and host defense responses to bacterial infection. J Immunol. 2011;186:1656-65 pubmed publisher
    ..These data demonstrate the unrealized physiologic role of this kinase in regulating the adhesion-mediated release of PMN granule contents. ..
  21. Huppi K, Siwarski D, Mock B, Dosik J, Hamel P. Molecular cloning, chromosomal mapping, and expression of the mouse p107 gene. Mamm Genome. 1996;7:353-5 pubmed
  22. Cougoule C, Le Cabec V, Poincloux R, Al Saati T, Mege J, Tabouret G, et al. Three-dimensional migration of macrophages requires Hck for podosome organization and extracellular matrix proteolysis. Blood. 2010;115:1444-52 pubmed publisher
    ..We investigated the role of Hck, a Src-family kinase involved in the organization of matrix adhesion and degradation structures called podosomes...
  23. Fumagalli L, Campa C, Germena G, Lowell C, Hirsch E, Berton G. Class I phosphoinositide-3-kinases and SRC kinases play a nonredundant role in regulation of adhesion-independent and -dependent neutrophil reactive oxygen species generation. J Immunol. 2013;190:3648-60 pubmed publisher
    ..responses using human neutrophils treated with inhibitory compounds or murine neutrophils deficient of PI3K? or Hck, Fgr, and Lyn...
  24. Nelson M, Christmann B, Werner J, Metz A, Trevor J, Lowell C, et al. IL-33 and M2a alveolar macrophages promote lung defense against the atypical fungal pathogen Pneumocystis murina. J Immunol. 2011;186:2372-81 pubmed publisher
    We have recently reported that mice deficient in the myeloid Src-family tyrosine kinases Hck, Fgr, and Lyn (Src triple knockout [TKO]) had augmented innate lung clearance of Pneumocystis murina that correlated with a higher ability of ..
  25. Alexandropoulos K, Cheng G, Baltimore D. Proline-rich sequences that bind to Src homology 3 domains with individual specificities. Proc Natl Acad Sci U S A. 1995;92:3110-4 pubmed
    ..The SH3 domains of the Src-related kinases Fyn, Lyn, and Hck bind to this sequence with the same affinity as that of the Src SH3...
  26. Wetzel D, Rhodes E, Li S, MCMAHON PRATT D, Koleske A. The Src kinases Hck, Fgr and Lyn activate Arg to facilitate IgG-mediated phagocytosis and Leishmania infection. J Cell Sci. 2016;129:3130-43 pubmed publisher
    ..small-molecule inhibitors and primary macrophages lacking specific Src family kinases, we now demonstrate that the Hck, Fgr and Lyn kinases are also necessary for amastigote uptake by macrophages...
  27. Verollet C, Zhang Y, Le Cabec V, Mazzolini J, Charrière G, Labrousse A, et al. HIV-1 Nef triggers macrophage fusion in a p61Hck- and protease-dependent manner. J Immunol. 2010;184:7030-9 pubmed publisher
    ..Nef has been shown to activate hematopoietic cell kinase (Hck), a Src tyrosine kinase specifically expressed in phagocytes, through a well-described polyproline-..
  28. Blanar M, Crossley P, Peters K, Steingr msson E, Copeland N, Jenkins N, et al. Meso1, a basic-helix-loop-helix protein involved in mammalian presomitic mesoderm development. Proc Natl Acad Sci U S A. 1995;92:5870-4 pubmed
    ..Our findings suggest that Meso1 may be a key regulatory gene involved in the early events of vertebrate mesoderm differentiation...
  29. Evangelista V, Pamuklar Z, Piccoli A, Manarini S, Dell Elba G, Pecce R, et al. Src family kinases mediate neutrophil adhesion to adherent platelets. Blood. 2007;109:2461-9 pubmed
    ..PMNs from alphaMbeta2(-/-), hck(-/-)fgr(-/-), and hck(-/-)fgr(-/-)lyn(-/-) mice had an impaired capacity to adhere with activated platelets in ..
  30. Baruzzi A, Iacobucci I, Soverini S, Lowell C, Martinelli G, Berton G. c-Abl and Src-family kinases cross-talk in regulation of myeloid cell migration. FEBS Lett. 2010;584:15-21 pubmed publisher
    Cytoskeleton dynamics are regulated by Src-family tyrosine kinases (SFKs) and c-Abl. We found that the SFK members Hck and c-Fgr regulate tyrosine phosphorylation of c-Abl and c-Abl associates with beta1 integrin-bound Hck or c-Fgr in ..
  31. Poh A, Love C, Masson F, Preaudet A, Tsui C, Whitehead L, et al. Inhibition of Hematopoietic Cell Kinase Activity Suppresses Myeloid Cell-Mediated Colon Cancer Progression. Cancer Cell. 2017;31:563-575.e5 pubmed publisher
    Aberrant activation of the SRC family kinase hematopoietic cell kinase (HCK) triggers hematological malignancies as a tumor cell-intrinsic oncogene...
  32. Khadaroo R, Kapus A, Powers K, Cybulsky M, Marshall J, Rotstein O. Oxidative stress reprograms lipopolysaccharide signaling via Src kinase-dependent pathway in RAW 264.7 macrophage cell line. J Biol Chem. 2003;278:47834-41 pubmed
  33. Siracusa L, Silan C, Justice M, Mercer J, Bauskin A, Ben Neriah Y, et al. A molecular genetic linkage map of mouse chromosome 2. Genomics. 1990;6:491-504 pubmed
    ..Comparisons between the mouse and the human genomes indicate that mouse chromosome 2 contains regions homologous to at least six human chromosomes. Mouse models for human diseases are discussed. ..
  34. Zaleskas V, Krause D, Lazarides K, Patel N, Hu Y, Li S, et al. Molecular pathogenesis and therapy of polycythemia induced in mice by JAK2 V617F. PLoS ONE. 2006;1:e18 pubmed
    ..Using donor mice with mutations in Lyn, Hck, and Fgr, we demonstrated that the polycythemia was independent of Src kinases...
  35. Caveggion E, Continolo S, Pixley F, Stanley E, Bowtell D, Lowell C, et al. Expression and tyrosine phosphorylation of Cbl regulates macrophage chemokinetic and chemotactic movement. J Cell Physiol. 2003;195:276-89 pubmed
    Primary macrophages isolated from hck(-/-)fgr(-/-) mice display altered morphology and F-actin cytoskeletal structures and reduced migration...
  36. Ernst M, Inglese M, Scholz G, Harder K, Clay F, Bozinovski S, et al. Constitutive activation of the SRC family kinase Hck results in spontaneous pulmonary inflammation and an enhanced innate immune response. J Exp Med. 2002;196:589-604 pubmed
    To identify the physiological role of Hck, a functionally redundant member of the Src family of tyrosine kinases expressed in myelomonocytic cells, we generated Hck(F/F) "knock-in" mice which carry a targeted tyrosine (Y) to ..
  37. Medina I, Cougoule C, Drechsler M, Bermudez B, Koenen R, Sluimer J, et al. Hck/Fgr Kinase Deficiency Reduces Plaque Growth and Stability by Blunting Monocyte Recruitment and Intraplaque Motility. Circulation. 2015;132:490-501 pubmed publisher
    ..Considering that Hck and Fgr are instrumental in this process, their impact on atherosclerosis and on lesion inflammation and stability ..
  38. Larsson Blomberg L, Dzierzak E. Isolation of tyrosine kinase related genes expressed in the early hematopoietic system. FEBS Lett. 1994;348:119-25 pubmed
    ..Here we describe the twelve isolated kinases, the specific expression patterns of flk-1, tek and ryk kinases and their potential relationship to the development of the hematopoietic system. ..
  39. Nelson M, Metz A, Li S, Lowell C, Steele C. The absence of Hck, Fgr, and Lyn tyrosine kinases augments lung innate immune responses to Pneumocystis murina. Infect Immun. 2009;77:1790-7 pubmed publisher
    ..As myeloid cells preferentially express the SFKs Hck, Fgr, and Lyn, we questioned the role of these kinases in innate immune responses to Pneumocystis murina...
  40. Holtzman D, Cook W, Dunn A. Isolation and sequence of a cDNA corresponding to a src-related gene expressed in murine hemopoietic cells. Proc Natl Acad Sci U S A. 1987;84:8325-9 pubmed
    ..and in cell lines representing both the myeloid and lymphoid B-cell lineages and, accordingly, is designated "bmk" (B cell/myeloid kinase)...
  41. Ziegler S, Pleiman C, Perlmutter R. Structure and expression of the murine hck gene. Oncogene. 1991;6:283-8 pubmed
    The hck gene encodes a src-like protein-tyrosine kinase that is expressed predominantly in cells of myeloid origin...
  42. Valenzuela D, Griffiths J, Rojas J, Aldrich T, Jones P, Zhou H, et al. Angiopoietins 3 and 4: diverging gene counterparts in mice and humans. Proc Natl Acad Sci U S A. 1999;96:1904-9 pubmed
    ..Angiopoietin-3 and angiopoietin-4 have very different distributions in their respective species, and angiopoietin-3 appears to act as an antagonist, whereas angiopoietin-4 appears to function as an agonist. ..
  43. Mermel C, McLemore M, Liu F, Pereira S, Woloszynek J, Lowell C, et al. Src family kinases are important negative regulators of G-CSF-dependent granulopoiesis. Blood. 2006;108:2562-8 pubmed
    ..We show that Hck and Lyn, Src family kinases expressed in myeloid cells, are negative regulators of granulopoiesis that act at ..
  44. Bisson S, Ujack E, Robbins S. Isolation and characterization of a novel, transforming allele of the c-Cbl proto-oncogene from a murine macrophage cell line. Oncogene. 2002;21:3677-87 pubmed
    ..p95Cbl displays a propensity for its interaction with the Src-family kinase Hck over cellular Cbl expressed in the same cells...
  45. Kitaura J, Eto K, Kinoshita T, Kawakami Y, Leitges M, Lowell C, et al. Regulation of highly cytokinergic IgE-induced mast cell adhesion by Src, Syk, Tec, and protein kinase C family kinases. J Immunol. 2005;174:4495-504 pubmed
    ..Importantly, we have identified Lyn and Syk as requisite tyrosine kinases and Hck, Btk, and protein kinase C theta as contributory kinases in HC IgE-induced adhesion and spreading, whereas protein ..
  46. Cory G, Garg R, Cramer R, Ridley A. Phosphorylation of tyrosine 291 enhances the ability of WASp to stimulate actin polymerization and filopodium formation. Wiskott-Aldrich Syndrome protein. J Biol Chem. 2002;277:45115-21 pubmed
    ..Here we show that the Src family kinase Hck induces phosphorylation of WASp-Tyr(291) independently of Cdc42 and that this causes a shift in the mobility of ..
  47. Jenkins N, Mattei M, Gilbert D, Linard C, Mbikay M, Chretien M, et al. Assignment of secretogranin I locus to mouse chromosome 2 by in situ hybridization and interspecific backcross analysis. Genomics. 1991;11:479-80 pubmed
  48. Klemsz M, McKercher S, Maki R. Nucleotide sequence of the mouse hck gene. Nucleic Acids Res. 1987;15:9600 pubmed
  49. Siyanova E, Serfas M, Mazo I, Tyner A. Tyrosine kinase gene expression in the mouse small intestine. Oncogene. 1994;9:2053-7 pubmed
    ..resulted in the identification of the catalytic domains of several characterized tyrosine kinases, including lyn, hck, c-fgr, tec, JAK2, itk, and the putative receptor kinase ryk, and expression of these kinases has not previously ..
  50. Shi Y, Dong B, Miliotis H, Liu J, Alberts A, Zhang J, et al. Src kinase Hck association with the WASp and mDia1 cytoskeletal regulators promotes chemoattractant-induced Hck membrane targeting and activation in neutrophils. Biochem Cell Biol. 2009;87:207-16 pubmed publisher
    The haemopoietic cell kinase (Hck) plays an important but poorly understood role in coupling chemoattractant stimuli to the actin cytoskeletal rearrangement required for neutrophil polarization and chemotaxis...
  51. Lock P, Ralph S, Stanley E, Boulet I, Ramsay R, Dunn A. Two isoforms of murine hck, generated by utilization of alternative translational initiation codons, exhibit different patterns of subcellular localization. Mol Cell Biol. 1991;11:4363-70 pubmed
    Mammalian hck, a member of the src family of tyrosine kinases, is expressed predominantly in cells of the myeloid and B-lymphoid lineages...
  52. Mazzi P, Caveggion E, Lapinet Vera J, Lowell C, Berton G. The Src-Family Kinases Hck and Fgr Regulate Early Lipopolysaccharide-Induced Myeloid Cell Recruitment into the Lung and Their Ability To Secrete Chemokines. J Immunol. 2015;195:2383-95 pubmed publisher
    ..We report that Hck- and Fgr-deficient mice show a profound impairment in early recruitment of neutrophils and monocytes in response to ..
  53. Nemeth T, Virtic O, Sitaru C, Mocsai A. The Syk Tyrosine Kinase Is Required for Skin Inflammation in an In Vivo Mouse Model of Epidermolysis Bullosa Acquisita. J Invest Dermatol. 2017;137:2131-2139 pubmed publisher
  54. Dale B, Traum D, Erdjument Bromage H, Tempst P, Greenberg S. Phagocytosis in macrophages lacking Cbl reveals an unsuspected role for Fc gamma receptor signaling and actin assembly in target binding. J Immunol. 2009;182:5654-62 pubmed publisher
    ..In resting cells, Fc gammaRI colocalized with the Src family TK Hck in F-actin-rich structures, which was enhanced in Cbl-deficient macrophages...
  55. Orschell C, Borneo J, Munugalavadla V, Ma P, Sims E, Ramdas B, et al. Deficiency of Src family kinases compromises the repopulating ability of hematopoietic stem cells. Exp Hematol. 2008;36:655-66 pubmed publisher
    ..Here we show that loss of hematopoietic-specific SFKs Hck, Fgr, and Lyn results in increased number of Sca-1(+)Lin(-) cells in the bone marrow, which respond differentially ..
  56. Vines C, Potter J, Xu Y, Geahlen R, Costello P, Tybulewicz V, et al. Inhibition of beta 2 integrin receptor and Syk kinase signaling in monocytes by the Src family kinase Fgr. Immunity. 2001;15:507-19 pubmed
    ..The inhibitory effects of Fgr are independent of its kinase activity, are dose dependent, and can be overcome by chemokines and inflammatory mediators. ..
  57. Park H, Dovas A, Hanna S, Lastrucci C, Cougoule C, Guiet R, et al. Tyrosine phosphorylation of Wiskott-Aldrich syndrome protein (WASP) by Hck regulates macrophage function. J Biol Chem. 2014;289:7897-906 pubmed publisher
    ..Here, we provide evidence that Hck, which is predominantly expressed in leukocytes, can tyrosine phosphorylate WASP and regulates WASP-mediated ..
  58. Yokoyama N, Malbon C. Dishevelled-2 docks and activates Src in a Wnt-dependent manner. J Cell Sci. 2009;122:4439-51 pubmed publisher
    ..Activated Src, in turn, enhances Wnt activation of the canonical pathway. We show that Dvl2 and beta-catenin are crucially important substrates for tyrosine phosphorylation in the canonical Wnt/beta-catenin pathway. ..
  59. Nemeth T, Futosi K, Sitaru C, Ruland J, Mocsai A. Neutrophil-specific deletion of the CARD9 gene expression regulator suppresses autoantibody-induced inflammation in vivo. Nat Commun. 2016;7:11004 pubmed publisher
    ..Collectively, CARD9-mediated gene expression changes within neutrophils play important roles during non-infectious inflammation in vivo and CARD9 acts as a divergence point between chemokine/cytokine and lipid mediator release. ..
  60. Paul R, Obermaier B, Van Ziffle J, Angele B, Pfister H, Lowell C, et al. Myeloid Src kinases regulate phagocytosis and oxidative burst in pneumococcal meningitis by activating NADPH oxidase. J Leukoc Biol. 2008;84:1141-50 pubmed publisher
    ..Myeloid Src family kinases (SFKs) p59/61(hck) (Hck), p58(c-fgr) (Fgr), and p53/56(lyn) (Lyn) are known to control integrin beta(2) signal transduction and ..
  61. Choi K, Jun H, Kim H, Park H, Eom Y, Noh H, et al. Role of Hck in the pathogenesis of encephalomyocarditis virus-induced diabetes in mice. J Virol. 2001;75:1949-57 pubmed
    ..We examined the activation of p59/p56(Hck), p55(Fgr), and p56/p53(Lyn) in macrophages from DBA/2 mice infected with the virus...
  62. Ruiz J, Conlon F, Robertson E. Identification of novel protein kinases expressed in the myocardium of the developing mouse heart. Mech Dev. 1994;48:153-64 pubmed
    ..75-8.5 dpc developing heart. Subsequently, msk mRNA expression is rapidly downregulated. The patterns of Hek2 and msk expression suggest that these protein kinases may function during development of the primitive heart. ..
  63. Shao B, Wahrenbrock M, Yao L, David T, Coughlin S, Xia L, et al. Carcinoma mucins trigger reciprocal activation of platelets and neutrophils in a murine model of Trousseau syndrome. Blood. 2011;118:4015-23 pubmed publisher
    ..Thus, carcinoma mucins promote thrombosis through adhesion-dependent, bidirectional signaling in neutrophils and platelets. ..
  64. Rinke De Wit T, Izon D, Revilla C, Oosterwegel M, Bakker A, van Ewijk W, et al. Expression of tyrosine kinase gene in mouse thymic stromal cells. Int Immunol. 1996;8:1787-95 pubmed
    ..These data provide the first example of a receptor PTK in TSC and open new approaches to study the regulation of TSC differentiation. ..
  65. Shao B, Yago T, Coghill P, Klopocki A, Mehta D souza P, Schmidtke D, et al. Signal-dependent slow leukocyte rolling does not require cytoskeletal anchorage of P-selectin glycoprotein ligand-1 (PSGL-1) or integrin ?L?2. J Biol Chem. 2012;287:19585-98 pubmed publisher
    ..The cytoskeletal independence of PSGL-1-initiated, ?(L)?(2)-mediated slow rolling differs markedly from the cytoskeletal dependence of chemokine-initiated, ?(L)?(2)-mediated arrest. ..
  66. Wei C, Li L, Menon M, Zhang W, Fu J, Kidd B, et al. Genomic Analysis of Kidney Allograft Injury Identifies Hematopoietic Cell Kinase as a Key Driver of Renal Fibrosis. J Am Soc Nephrol. 2017;28:1385-1393 pubmed publisher
    ..We identified an Src family tyrosine kinase, hematopoietic cell kinase (Hck), as upregulated in allografts in CAI...
  67. Zarbock A, Abram C, Hundt M, Altman A, Lowell C, Ley K. PSGL-1 engagement by E-selectin signals through Src kinase Fgr and ITAM adapters DAP12 and FcR gamma to induce slow leukocyte rolling. J Exp Med. 2008;205:2339-47 pubmed publisher
    ..E-selectin-mediated phosphorylation of Syk and slow rolling was abolished in neutrophils from fgr(-/-) or hck(-/-) lyn(-/-) fgr(-/-) mice...
  68. Majeed M, Caveggion E, Lowell C, Berton G. Role of Src kinases and Syk in Fcgamma receptor-mediated phagocytosis and phagosome-lysosome fusion. J Leukoc Biol. 2001;70:801-11 pubmed
    ..Similar studies with macrophages lacking the Src family kinases Hck, Fgr, and Lyn showed that these kinases are not required for phagocytosis but that they enhance the rate of ..
  69. Verollet C, Gallois A, Dacquin R, Lastrucci C, Pandruvada S, Ortega N, et al. Hck contributes to bone homeostasis by controlling the recruitment of osteoclast precursors. FASEB J. 2013;27:3608-18 pubmed publisher
    ..Since this phenotype was even more severe in src(-/-)hck(-/-) mice, we examined the individual contribution of Hck in bone homeostasis...
  70. Hong H, Kitaura J, Xiao W, Horejsi V, Ra C, Lowell C, et al. The Src family kinase Hck regulates mast cell activation by suppressing an inhibitory Src family kinase Lyn. Blood. 2007;110:2511-9 pubmed
    ..Here we show that a third SFK, Hck, plays a critical role in mast cell activation...
  71. Kovács M, Németh T, Jakus Z, Sitaru C, Simon E, Futosi K, et al. The Src family kinases Hck, Fgr, and Lyn are critical for the generation of the in vivo inflammatory environment without a direct role in leukocyte recruitment. J Exp Med. 2014;211:1993-2011 pubmed publisher
    ..Mice lacking the Src family kinases Hck, Fgr, and Lyn in the hematopoietic compartment were completely protected from autoantibody-induced arthritis and ..
  72. Lock P, Stanley E, Holtzman D, Dunn A. Functional analysis and nucleotide sequence of the promoter region of the murine hck gene. Mol Cell Biol. 1990;10:4603-11 pubmed
    The structure and function of the promoter region and exon 1 of the murine hck gene have been characterized in detail...