Genomes and Genes
Gene Symbol: Hcar1
Description: hydrocarboxylic acid receptor 1
Alias: Gpr81, hydroxycarboxylic acid receptor 1, G-protein coupled receptor 81
- Madaan A, Nadeau Vallée M, Rivera J, Obari D, Hou X, Sierra E, et al. Lactate produced during labor modulates uterine inflammation via GPR81 (HCA1). Am J Obstet Gynecol. 2017;216:60.e1-60.e17 pubmed publisher..Aside from its metabolic function, lactate has been shown to activate a G protein-coupled receptor, GPR81, reported to regulate inflammation...
- Ranganathan P, Shanmugam A, Swafford D, Suryawanshi A, Bhattacharjee P, Hussein M, et al. GPR81, a Cell-Surface Receptor for Lactate, Regulates Intestinal Homeostasis and Protects Mice from Experimental Colitis. J Immunol. 2018;200:1781-1789 pubmed publisher..In this study, we report that signaling by GPR81, a receptor for lactate, in colonic dendritic cells and macrophages plays an important role in suppressing colonic ..
- Ge H, Weiszmann J, Reagan J, Gupte J, Baribault H, Gyuris T, et al. Elucidation of signaling and functional activities of an orphan GPCR, GPR81. J Lipid Res. 2008;49:797-803 pubmed publisherb>GPR81 is an orphan G protein-coupled receptor (GPCR) that has a high degree of homology to the nicotinic acid receptor GPR109A. GPR81 expression is highly enriched and specific in adipocytes...
- Feingold K, Moser A, Shigenaga J, Grunfeld C. Inflammation inhibits GPR81 expression in adipose tissue. Inflamm Res. 2011;60:991-5 pubmed publisherThe aim of this study was to examine the expression of G protein-coupled receptor 81 (GPR81) in mouse adipose tissue in response to inflammatory stimuli. GPR81 is activated by lactate resulting in the inhibition of lipolysis...
- Morland C, Andersson K, Haugen Ø, Hadzic A, Kleppa L, Gille A, et al. Exercise induces cerebral VEGF and angiogenesis via the lactate receptor HCAR1. Nat Commun. 2017;8:15557 pubmed publisher..Here we show that the lactate receptor (HCAR1) is highly enriched in pial fibroblast-like cells that line the vessels supplying blood to the brain, and in ..