Hbq1a

Summary

Gene Symbol: Hbq1a
Description: hemoglobin, theta 1A
Alias: A230090E05Rik, Gm876, Hbq1, Hbqt2, hemoglobin, theta T2, Hbq1 3'-theta, hemoglobin, theta 1
Species: mouse
Products:     Hbq1a

Top Publications

  1. Anguita E, Hughes J, Heyworth C, Blobel G, Wood W, Higgs D. Globin gene activation during haemopoiesis is driven by protein complexes nucleated by GATA-1 and GATA-2. EMBO J. 2004;23:2841-52 pubmed
  2. Lynch M, Smith A, De Gobbi M, Flenley M, Hughes J, Vernimmen D, et al. An interspecies analysis reveals a key role for unmethylated CpG dinucleotides in vertebrate Polycomb complex recruitment. EMBO J. 2012;31:317-29 pubmed publisher
    ..Furthermore, our results suggest that a high density of unmethylated CpG dinucleotides is sufficient for vertebrate Polycomb recruitment. This model is supported by analysis of DNA methyltransferase-deficient embryonic stem cells. ..
  3. Flint J, Tufarelli C, Peden J, Clark K, Daniels R, Hardison R, et al. Comparative genome analysis delimits a chromosomal domain and identifies key regulatory elements in the alpha globin cluster. Hum Mol Genet. 2001;10:371-82 pubmed
    ..In addition to delimiting the alpha globin chromosomal domain, this study has enabled us to develop a more sensitive and accurate routine for identifying regulatory elements in the human genome. ..
  4. Wallace H, Marques Kranc F, Richardson M, Luna Crespo F, Sharpe J, Hughes J, et al. Manipulating the mouse genome to engineer precise functional syntenic replacements with human sequence. Cell. 2007;128:197-209 pubmed
    ..RMGR has general applicability and will overcome limitations inherent in current transgenic technology when studying the expression of human genes and modeling human genetic diseases. ..
  5. Storz J, Hoffmann F, Opazo J, Moriyama H. Adaptive functional divergence among triplicated alpha-globin genes in rodents. Genetics. 2008;178:1623-38 pubmed publisher