Gene Symbol: Hbp1
Description: high mobility group box transcription factor 1
Alias: 1700058O05Rik, BE629963, C330012F01Rik, C86454, HMG box-containing protein 1, HMG box transcription factor 1
Species: mouse
Products:     Hbp1

Top Publications

  1. Swanson K, Knoepfler P, Huang K, Kang R, Cowley S, Laherty C, et al. HBP1 and Mad1 repressors bind the Sin3 corepressor PAH2 domain with opposite helical orientations. Nat Struct Mol Biol. 2004;11:738-46 pubmed
    ..Here we show that HBP1, a cell cycle inhibitor and regulator of differentiation, represses transcription in a HDAC/Sin3-dependent manner ..
  2. Borrelli S, Candi E, Hu B, Dolfini D, Ravo M, Grober O, et al. The p63 target HBP1 is required for skin differentiation and stratification. Cell Death Differ. 2010;17:1896-907 pubmed publisher
    ..targets of p63 in keratinocytes, we identified the transcription factor, High Mobility Group (HMG) box protein 1 (HBP1). HBP1 is an HMG-containing repressor transiently induced during differentiation of several cell lineages...
  3. Dong Z, Huang M, Liu Z, Xie P, Dong Y, Wu X, et al. Focused screening of mitochondrial metabolism reveals a crucial role for a tumor suppressor Hbp1 in ovarian reserve. Cell Death Differ. 2016;23:1602-14 pubmed publisher
    ..The results uncovered roles for several tumor suppressors, including HBP1, in the augmentation of mitochondrial function...
  4. Tevosian S, Shih H, Mendelson K, Sheppard K, Paulson K, Yee A. HBP1: a HMG box transcriptional repressor that is targeted by the retinoblastoma family. Genes Dev. 1997;11:383-96 pubmed
    ..We have isolated the HBP1 transcriptional repressor as a potential target of the RB family in differentiated cells...
  5. Lavender P, Vandel L, Bannister A, Kouzarides T. The HMG-box transcription factor HBP1 is targeted by the pocket proteins and E1A. Oncogene. 1997;14:2721-8 pubmed
    A yeast two-hybrid screen has identified HBP1 as a transcription factor capable of interacting with the pocket protein family. We show that HBP1 can interact with one of these, RB, both in vitro and in mammalian cells...
  6. de Chiara C, Giannini C, Adinolfi S, de Boer J, Guida S, Ramos A, et al. The AXH module: an independently folded domain common to ataxin-1 and HBP1. FEBS Lett. 2003;551:107-12 pubmed
    ..type 1 in humans, shares a region of homology, named AXH module, with the apparently unrelated transcription factor HBP1. Here, we describe the first characterisation of the AXH module in terms of its structural properties and stability...
  7. Xiu M, Kim J, Sampson E, Huang C, Davis R, Paulson K, et al. The transcriptional repressor HBP1 is a target of the p38 mitogen-activated protein kinase pathway in cell cycle regulation. Mol Cell Biol. 2003;23:8890-901 pubmed
    ..Here, we identify the high-mobility group box protein HBP1 transcriptional repressor as a new substrate for p38 MAP kinase...
  8. de Chiara C, Kelly G, Frenkiel T, Pastore A. Assignment of the 1H, 13C, and 15N resonances of the AXH domain of the transcription factor HBP1. J Biomol NMR. 2004;28:411-2 pubmed
  9. Tian F, An L, Wang G, Zhu J, Li Q, Zhang Y, et al. Elevated microRNA-155 promotes foam cell formation by targeting HBP1 in atherogenesis. Cardiovasc Res. 2014;103:100-10 pubmed publisher
    ..Furthermore, ectopic overexpression and knockdown experiments identified that HMG box-transcription protein1 (HBP1) is a novel target of miR-155...

More Information


  1. Coomans de Brachène A, Bollaert E, Eijkelenboom A, de Rocca Serra A, van der Vos K, Burgering B, et al. The expression of the tumour suppressor HBP1 is down-regulated by growth factors via the PI3K/PKB/FOXO pathway. Biochem J. 2014;460:25-34 pubmed publisher
    ..By comparing microarray data from multiple model systems, we identified HBP1 (high-mobility group-box protein 1) as a novel downstream target of this pathway...
  2. Zhuma T, Tyrrell R, Sekkali B, Skavdis G, Saveliev A, Tolaini M, et al. Human HMG box transcription factor HBP1: a role in hCD2 LCR function. EMBO J. 1999;18:6396-406 pubmed
    ..Here, we identified the HMG box containing protein-1 (HBP1) as a factor binding to HSS3 of the hCD2 LCR...
  3. Shih H, Xiu M, Berasi S, Sampson E, Leiter A, Paulson K, et al. HMG box transcriptional repressor HBP1 maintains a proliferation barrier in differentiated liver tissue. Mol Cell Biol. 2001;21:5723-32 pubmed
    We previously isolated HBP1 as a target of the retinoblastoma (RB) and p130 family members and as the first of the HMG box transcriptional repressors...
  4. Smith J, Bowles J, Wilson M, Koopman P. HMG box transcription factor gene Hbp1 is expressed in germ cells of the developing mouse testis. Dev Dyn. 2004;230:366-70 pubmed
    b>HMG box containing protein 1 (HBP1) is a high mobility group domain transcriptional repressor that regulates proliferation in differentiated tissues...
  5. Spiller C, Wilhelm D, Jans D, Bowles J, Koopman P. Mice Lacking Hbp1 Function Are Viable and Fertile. PLoS ONE. 2017;12:e0170576 pubmed publisher
    ..High mobility group box containing transcription factor 1 (HBP1) is a transcription factor that was previously identified in fetal male germ cells at the time of embryonic cell ..