Hamp

Summary

Gene Symbol: Hamp
Description: hepcidin antimicrobial peptide
Alias: Hamp1, Hepc, Hepc1, hepcidin, hepcidin antimicrobial peptide 1
Species: mouse
Products:     Hamp

Top Publications

  1. Pagani A, Nai A, Corna G, Bosurgi L, Rovere Querini P, Camaschella C, et al. Low hepcidin accounts for the proinflammatory status associated with iron deficiency. Blood. 2011;118:736-46 pubmed publisher
    b>Hepcidin is an antimicrobial peptide that controls systemic iron homeostasis. Hepcidin binding to its receptor ferroportin reduces iron availability, thus controlling microbial growth...
  2. Nemeth E, Tuttle M, Powelson J, Vaughn M, Donovan A, Ward D, et al. Hepcidin regulates cellular iron efflux by binding to ferroportin and inducing its internalization. Science. 2004;306:2090-3 pubmed
    b>Hepcidin is a peptide hormone secreted by the liver in response to iron loading and inflammation. Decreased hepcidin leads to tissue iron overload, whereas hepcidin overproduction leads to hypoferremia and the anemia of inflammation...
  3. Wilkins S, Frazer D, Millard K, McLaren G, Anderson G. Iron metabolism in the hemoglobin-deficit mouse: correlation of diferric transferrin with hepcidin expression. Blood. 2006;107:1659-64 pubmed
    The iron requirements of the erythroid compartment modulate the expression of hepcidin in the liver, which in turn alters intestinal iron absorption and iron release from the reticuloendothelial system...
  4. Nicolas G, Bennoun M, Porteu A, Mativet S, Beaumont C, Grandchamp B, et al. Severe iron deficiency anemia in transgenic mice expressing liver hepcidin. Proc Natl Acad Sci U S A. 2002;99:4596-601 pubmed
    ..trait could be attributed to the absence, in the Usf2 knockout mice, of a secreted liver-specific peptide, hepcidin. We conjectured that the reverse situation, namely overexpression of hepcidin, might result in phenotypic traits ..
  5. Lou D, Lesbordes J, Nicolas G, Viatte L, Bennoun M, Van Rooijen N, et al. Iron- and inflammation-induced hepcidin gene expression in mice is not mediated by Kupffer cells in vivo. Hepatology. 2005;41:1056-64 pubmed
    b>Hepcidin, a recently discovered iron regulatory peptide, is believed to inhibit the release of iron from absorptive enterocytes and macrophages. Liver hepcidin synthesis is induced in vivo by iron stores and inflammation...
  6. Wallace D, Summerville L, Crampton E, Frazer D, Anderson G, Subramaniam V. Combined deletion of Hfe and transferrin receptor 2 in mice leads to marked dysregulation of hepcidin and iron overload. Hepatology. 2009;50:1992-2000 pubmed publisher
    b>Hepcidin is a central regulator of iron homeostasis. HFE and transferrin receptor 2 (TFR2) are mutated in adult-onset forms of hereditary hemochromatosis and regulate the expression of hepcidin in response to iron...
  7. Wang R, Li C, Xu X, Zheng Y, Xiao C, Zerfas P, et al. A role of SMAD4 in iron metabolism through the positive regulation of hepcidin expression. Cell Metab. 2005;2:399-409 pubmed
    ..b>Hepcidin, which is synthesized in the liver, plays important roles in iron overload syndromes...
  8. Delaby C, Pilard N, Gonçalves A, Beaumont C, Canonne Hergaux F. Presence of the iron exporter ferroportin at the plasma membrane of macrophages is enhanced by iron loading and down-regulated by hepcidin. Blood. 2005;106:3979-84 pubmed
    ..Moreover, hepcidin dramatically reduced macrophage ferroportin protein levels...
  9. Gardenghi S, Marongiu M, Ramos P, Guy E, Breda L, Chadburn A, et al. Ineffective erythropoiesis in beta-thalassemia is characterized by increased iron absorption mediated by down-regulation of hepcidin and up-regulation of ferroportin. Blood. 2007;109:5027-35 pubmed
    ..Our study reveals that the degree of IE dictates tissue iron distribution and that IE and iron content regulate hepcidin (Hamp1) and other iron-regulatory genes such as Hfe and Cebpa...
  10. Ding H, Yan C, Shi H, Zhao Y, Chang S, Yu P, et al. Hepcidin is involved in iron regulation in the ischemic brain. PLoS ONE. 2011;6:e25324 pubmed publisher
    ..In order to elucidate the mechanisms of FPN1 regulation, we studied the expression of the key regulator of FPN1, hepcidin. We observed that the hepcidin level was significantly elevated in the ischemic side of the brain...

Detail Information

Publications62

  1. Pagani A, Nai A, Corna G, Bosurgi L, Rovere Querini P, Camaschella C, et al. Low hepcidin accounts for the proinflammatory status associated with iron deficiency. Blood. 2011;118:736-46 pubmed publisher
    b>Hepcidin is an antimicrobial peptide that controls systemic iron homeostasis. Hepcidin binding to its receptor ferroportin reduces iron availability, thus controlling microbial growth...
  2. Nemeth E, Tuttle M, Powelson J, Vaughn M, Donovan A, Ward D, et al. Hepcidin regulates cellular iron efflux by binding to ferroportin and inducing its internalization. Science. 2004;306:2090-3 pubmed
    b>Hepcidin is a peptide hormone secreted by the liver in response to iron loading and inflammation. Decreased hepcidin leads to tissue iron overload, whereas hepcidin overproduction leads to hypoferremia and the anemia of inflammation...
  3. Wilkins S, Frazer D, Millard K, McLaren G, Anderson G. Iron metabolism in the hemoglobin-deficit mouse: correlation of diferric transferrin with hepcidin expression. Blood. 2006;107:1659-64 pubmed
    The iron requirements of the erythroid compartment modulate the expression of hepcidin in the liver, which in turn alters intestinal iron absorption and iron release from the reticuloendothelial system...
  4. Nicolas G, Bennoun M, Porteu A, Mativet S, Beaumont C, Grandchamp B, et al. Severe iron deficiency anemia in transgenic mice expressing liver hepcidin. Proc Natl Acad Sci U S A. 2002;99:4596-601 pubmed
    ..trait could be attributed to the absence, in the Usf2 knockout mice, of a secreted liver-specific peptide, hepcidin. We conjectured that the reverse situation, namely overexpression of hepcidin, might result in phenotypic traits ..
  5. Lou D, Lesbordes J, Nicolas G, Viatte L, Bennoun M, Van Rooijen N, et al. Iron- and inflammation-induced hepcidin gene expression in mice is not mediated by Kupffer cells in vivo. Hepatology. 2005;41:1056-64 pubmed
    b>Hepcidin, a recently discovered iron regulatory peptide, is believed to inhibit the release of iron from absorptive enterocytes and macrophages. Liver hepcidin synthesis is induced in vivo by iron stores and inflammation...
  6. Wallace D, Summerville L, Crampton E, Frazer D, Anderson G, Subramaniam V. Combined deletion of Hfe and transferrin receptor 2 in mice leads to marked dysregulation of hepcidin and iron overload. Hepatology. 2009;50:1992-2000 pubmed publisher
    b>Hepcidin is a central regulator of iron homeostasis. HFE and transferrin receptor 2 (TFR2) are mutated in adult-onset forms of hereditary hemochromatosis and regulate the expression of hepcidin in response to iron...
  7. Wang R, Li C, Xu X, Zheng Y, Xiao C, Zerfas P, et al. A role of SMAD4 in iron metabolism through the positive regulation of hepcidin expression. Cell Metab. 2005;2:399-409 pubmed
    ..b>Hepcidin, which is synthesized in the liver, plays important roles in iron overload syndromes...
  8. Delaby C, Pilard N, Gonçalves A, Beaumont C, Canonne Hergaux F. Presence of the iron exporter ferroportin at the plasma membrane of macrophages is enhanced by iron loading and down-regulated by hepcidin. Blood. 2005;106:3979-84 pubmed
    ..Moreover, hepcidin dramatically reduced macrophage ferroportin protein levels...
  9. Gardenghi S, Marongiu M, Ramos P, Guy E, Breda L, Chadburn A, et al. Ineffective erythropoiesis in beta-thalassemia is characterized by increased iron absorption mediated by down-regulation of hepcidin and up-regulation of ferroportin. Blood. 2007;109:5027-35 pubmed
    ..Our study reveals that the degree of IE dictates tissue iron distribution and that IE and iron content regulate hepcidin (Hamp1) and other iron-regulatory genes such as Hfe and Cebpa...
  10. Ding H, Yan C, Shi H, Zhao Y, Chang S, Yu P, et al. Hepcidin is involved in iron regulation in the ischemic brain. PLoS ONE. 2011;6:e25324 pubmed publisher
    ..In order to elucidate the mechanisms of FPN1 regulation, we studied the expression of the key regulator of FPN1, hepcidin. We observed that the hepcidin level was significantly elevated in the ischemic side of the brain...
  11. Lesbordes Brion J, Viatte L, Bennoun M, Lou D, Ramey G, Houbron C, et al. Targeted disruption of the hepcidin 1 gene results in severe hemochromatosis. Blood. 2006;108:1402-5 pubmed
    We previously reported that mice made deficient for the transcriptional factor USF2 fail to express hepcidin 1 and hepcidin 2 genes as a consequence of targeted disruption of the Usf2 gene lying just upstream in the locus...
  12. Besson Fournier C, Latour C, Kautz L, Bertrand J, Ganz T, Roth M, et al. Induction of activin B by inflammatory stimuli up-regulates expression of the iron-regulatory peptide hepcidin through Smad1/5/8 signaling. Blood. 2012;120:431-9 pubmed publisher
    ..It is mediated by excessive production of the iron-regulatory peptide hepcidin, but the signaling pathway responsible for hepcidin up-regulation in the inflammatory context is still not ..
  13. Kautz L, Meynard D, Monnier A, Darnaud V, Bouvet R, Wang R, et al. Iron regulates phosphorylation of Smad1/5/8 and gene expression of Bmp6, Smad7, Id1, and Atoh8 in the mouse liver. Blood. 2008;112:1503-9 pubmed publisher
    Although hepcidin expression was shown to be induced by the BMP/Smad signaling pathway, it is not yet known how iron regulates this pathway and what its exact molecular targets are...
  14. Veuthey T, D Anna M, Roque M. Role of the kidney in iron homeostasis: renal expression of Prohepcidin, Ferroportin, and DMT1 in anemic mice. Am J Physiol Renal Physiol. 2008;295:F1213-21 pubmed publisher
    ..Further research is required to learn more about these regulatory mechanisms. ..
  15. Krijt J, Cmejla R, Sýkora V, Vokurka M, Vyoral D, Necas E. Different expression pattern of hepcidin genes in the liver and pancreas of C57BL/6N and DBA/2N mice. J Hepatol. 2004;40:891-6 pubmed
    ..The aim of this study was to examine possible differences in the expression of hepcidin genes (Hamp and Hamp2) between the two strains. Hepatic mRNAs were quantified by real-time PCR...
  16. Krijt J, Vokurka M, Chang K, Necas E. Expression of Rgmc, the murine ortholog of hemojuvelin gene, is modulated by development and inflammation, but not by iron status or erythropoietin. Blood. 2004;104:4308-10 pubmed
    Mutations of hepcidin (HAMP) and hemo-juvelin (HJV) genes have been recently demonstrated to result in juvenile hemochromatosis. Expression of HAMP is regulated by iron status or infection, whereas regulation of HJV is yet unknown...
  17. Pigeon C, Ilyin G, Courselaud B, Leroyer P, Turlin B, Brissot P, et al. A new mouse liver-specific gene, encoding a protein homologous to human antimicrobial peptide hepcidin, is overexpressed during iron overload. J Biol Chem. 2001;276:7811-9 pubmed
    ..an 83-amino acid protein presenting a strong homology in its C-terminal region to the human antimicrobial peptide hepcidin. In addition, we cloned the corresponding rat and human orthologue cDNAs...
  18. Nemeth E, Rivera S, Gabayan V, Keller C, Taudorf S, Pedersen B, et al. IL-6 mediates hypoferremia of inflammation by inducing the synthesis of the iron regulatory hormone hepcidin. J Clin Invest. 2004;113:1271-6 pubmed
    ..In mouse models, the development of hypoferremia during inflammation requires hepcidin, an iron regulatory peptide hormone produced in the liver, but the inflammatory signals that regulate hepcidin ..
  19. Nicolas G, Bennoun M, Devaux I, Beaumont C, Grandchamp B, Kahn A, et al. Lack of hepcidin gene expression and severe tissue iron overload in upstream stimulatory factor 2 (USF2) knockout mice. Proc Natl Acad Sci U S A. 2001;98:8780-5 pubmed
    ..We isolated a cDNA encoding a peptide, hepcidin (also referred to as LEAP-1, for liver-expressed antimicrobial peptide), that was very recently purified from ..
  20. Truksa J, Peng H, Lee P, Beutler E. Bone morphogenetic proteins 2, 4, and 9 stimulate murine hepcidin 1 expression independently of Hfe, transferrin receptor 2 (Tfr2), and IL-6. Proc Natl Acad Sci U S A. 2006;103:10289-10293 pubmed publisher
    Recently, it has been suggested that hepcidin, a peptide involved in iron homeostasis, is regulated by bone morphogenetic proteins (BMPs), apparently by binding to hemojuvelin (Hjv) as a coreceptor and signaling through Smad4...
  21. Ramos E, Ruchala P, Goodnough J, Kautz L, Preza G, Nemeth E, et al. Minihepcidins prevent iron overload in a hepcidin-deficient mouse model of severe hemochromatosis. Blood. 2012;120:3829-36 pubmed publisher
    The deficiency of hepcidin, the hormone that controls iron absorption and its tissue distribution, is the cause of iron overload in nearly all forms of hereditary hemochromatosis and in untransfused iron-loading anemias...
  22. Pietrangelo A, Dierssen U, Valli L, Garuti C, Rump A, Corradini E, et al. STAT3 is required for IL-6-gp130-dependent activation of hepcidin in vivo. Gastroenterology. 2007;132:294-300 pubmed
    b>Hepcidin is a peptide hormone that is central to the regulation of iron homeostasis...
  23. Ilyin G, Courselaud B, Troadec M, Pigeon C, Alizadeh M, Leroyer P, et al. Comparative analysis of mouse hepcidin 1 and 2 genes: evidence for different patterns of expression and co-inducibility during iron overload. FEBS Lett. 2003;542:22-6 pubmed
    In contrast to the human genome, the mouse genome contains two HEPC genes encoding hepcidin, a key regulator of iron homeostasis...
  24. Andriopoulos B, Corradini E, Xia Y, Faasse S, Chen S, Grgurevic L, et al. BMP6 is a key endogenous regulator of hepcidin expression and iron metabolism. Nat Genet. 2009;41:482-7 pubmed publisher
    ..is an iron-overload disorder caused by mutations in the genes encoding the major iron regulatory hormone hepcidin (HAMP) and hemojuvelin (HFE2)...
  25. Corradini E, Schmidt P, Meynard D, Garuti C, Montosi G, Chen S, et al. BMP6 treatment compensates for the molecular defect and ameliorates hemochromatosis in Hfe knockout mice. Gastroenterology. 2010;139:1721-9 pubmed publisher
    Abnormal hepcidin regulation is central to the pathogenesis of HFE hemochromatosis...
  26. Krijt J, Jonasova A, Neuwirtova R, Necas E. Effect of erythropoietin on hepcidin expression in hemojuvelin-mutant mice. Blood Cells Mol Dis. 2010;44:257-61 pubmed publisher
    Transcription of the hepcidin (Hamp) gene is controlled by iron stores and the rate of erythropoiesis. Functional hierarchy between these two stimuli has not yet been completely established...
  27. Wang S, Fu L, Duan X, Crooks D, Yu P, Qian Z, et al. Role of hepcidin in murine brain iron metabolism. Cell Mol Life Sci. 2010;67:123-33 pubmed publisher
    ..b>Hepcidin, an iron regulatory hormone produced by hepatocytes in response to inflammatory stimuli, iron, and hypoxia, has ..
  28. Ramos E, Kautz L, Rodriguez R, Hansen M, Gabayan V, Ginzburg Y, et al. Evidence for distinct pathways of hepcidin regulation by acute and chronic iron loading in mice. Hepatology. 2011;53:1333-41 pubmed publisher
    In response to iron loading, hepcidin synthesis is homeostatically increased to limit further absorption of dietary iron and its release from stores...
  29. Armitage A, Eddowes L, Gileadi U, Cole S, Spottiswoode N, Selvakumar T, et al. Hepcidin regulation by innate immune and infectious stimuli. Blood. 2011;118:4129-39 pubmed publisher
    b>Hepcidin controls the levels and distribution of iron, an element whose availability can influence the outcome of infections...
  30. Bartnikas T, Andrews N, Fleming M. Transferrin is a major determinant of hepcidin expression in hypotransferrinemic mice. Blood. 2011;117:630-7 pubmed publisher
    As a central regulator of iron metabolism, hepcidin inhibits dietary iron absorption and macrophage iron recycling. Its expression is regulated by multiple factors including iron availability and erythropoietic activity...
  31. Schmidt P, Toran P, Giannetti A, Bjorkman P, Andrews N. The transferrin receptor modulates Hfe-dependent regulation of hepcidin expression. Cell Metab. 2008;7:205-14 pubmed publisher
    ..Hfe/Tfr1 interaction, mice developed iron overload attributable to inappropriately low expression of the hormone hepcidin. In contrast, mice carrying a mutation that interferes with the Hfe/Tfr1 interaction developed iron deficiency ..
  32. Courselaud B, Troadec M, Fruchon S, Ilyin G, Borot N, Leroyer P, et al. Strain and gender modulate hepatic hepcidin 1 and 2 mRNA expression in mice. Blood Cells Mol Dis. 2004;32:283-9 pubmed
    b>Hepcidin (HEPC) plays a key role in iron homeostasis and an abnormally low level of hepcidin mRNA has been reported in HFE-1 genetic hemochromatosis...
  33. Park C, Valore E, Waring A, Ganz T. Hepcidin, a urinary antimicrobial peptide synthesized in the liver. J Biol Chem. 2001;276:7806-10 pubmed
    ..we characterized a cysteine-rich peptide with three forms differing by amino-terminal truncation, and we named it hepcidin (Hepc) because of its origin in the liver and its antimicrobial properties...
  34. Daba A, Gkouvatsos K, Sebastiani G, Pantopoulos K. Differences in activation of mouse hepcidin by dietary iron and parenterally administered iron dextran: compartmentalization is critical for iron sensing. J Mol Med (Berl). 2013;91:95-102 pubmed publisher
    The iron regulatory hormone hepcidin responds to both oral and parenteral iron. Here, we hypothesized that the diverse iron trafficking routes may affect the dynamics and kinetics of the hepcidin activation pathway...
  35. Ramos P, Guy E, Chen N, Proenca C, Gardenghi S, Casu C, et al. Enhanced erythropoiesis in Hfe-KO mice indicates a role for Hfe in the modulation of erythroid iron homeostasis. Blood. 2011;117:1379-89 pubmed publisher
    In hereditary hemochromatosis, mutations in HFE lead to iron overload through abnormally low levels of hepcidin. In addition, HFE potentially modulates cellular iron uptake by interacting with transferrin receptor, a crucial protein ..
  36. Rodrigues P, Gomes S, Neves J, Gomes Pereira S, Correia Neves M, Nunes Alves C, et al. Mycobacteria-induced anaemia revisited: a molecular approach reveals the involvement of NRAMP1 and lipocalin-2, but not of hepcidin. Immunobiology. 2011;216:1127-34 pubmed publisher
    ..Mycobacterium avium BALB/c mice exhibited a moderate anaemia, which was not accompanied by an increase on hepatic hepcidin mRNA expression...
  37. Lou D, Nicolas G, Lesbordes J, Viatte L, Grimber G, Szajnert M, et al. Functional differences between hepcidin 1 and 2 in transgenic mice. Blood. 2004;103:2816-21 pubmed
    b>Hepcidin is a 25-amino acid peptide involved in iron homeostasis in mice and humans. It is produced in the liver from a larger precursor, and it is detectable in blood and urine...
  38. Bartnikas T, Fleming M. Hemojuvelin is essential for transferrin-dependent and transferrin-independent hepcidin expression in mice. Haematologica. 2012;97:189-92 pubmed publisher
    Here we investigate the regulation of hepcidin, a hormone that inhibits dietary iron absorption and macrophage iron recycling, by the serum iron-binding protein transferrin...
  39. Vecchi C, Montosi G, Zhang K, Lamberti I, Duncan S, Kaufman R, et al. ER stress controls iron metabolism through induction of hepcidin. Science. 2009;325:877-80 pubmed publisher
    b>Hepcidin is a peptide hormone that is secreted by the liver and controls body iron homeostasis. Hepcidin overproduction causes anemia of inflammation, whereas its deficiency leads to hemochromatosis...
  40. Liu X, Nguyen N, Marquess K, Yang F, Haile D. Regulation of hepcidin and ferroportin expression by lipopolysaccharide in splenic macrophages. Blood Cells Mol Dis. 2005;35:47-56 pubmed
    ..In addition, these models have also demonstrated hepatic induction of mRNA of the small 25 amino acid peptide hepcidin. Hepcidin has been hypothesized to be the mediator of iron- and inflammation-induced changes in iron metabolism...
  41. Lee P, Peng H, Gelbart T, Wang L, Beutler E. Regulation of hepcidin transcription by interleukin-1 and interleukin-6. Proc Natl Acad Sci U S A. 2005;102:1906-10 pubmed
    b>Hepcidin is a peptide that regulates iron homeostasis by inhibiting iron absorption by the small intestine and release of iron from macrophages. Its production is stimulated by iron overload and by inflammation...
  42. D Anna M, Roque M. Physiological focus on the erythropoietin-hepcidin-ferroportin axis. Can J Physiol Pharmacol. 2013;91:338-45 pubmed publisher
    ..Our aim was to understand the functional axis response composed of erythropoietin (Epo)-hepcidin-ferroportin (FPN), when 2 dysfunctional states coexist, using an animal model of iron overload followed by ..
  43. Fatih N, Camberlein E, Island M, Corlu A, Abgueguen E, Detivaud L, et al. Natural and synthetic STAT3 inhibitors reduce hepcidin expression in differentiated mouse hepatocytes expressing the active phosphorylated STAT3 form. J Mol Med (Berl). 2010;88:477-86 pubmed publisher
    During the inflammatory process, hepcidin overexpression favours the development of anaemia of chronic diseases which represents the second most common form of anaemia worldwide...
  44. Theurl M, Song D, Clark E, Sterling J, Grieco S, Altamura S, et al. Mice with hepcidin-resistant ferroportin accumulate iron in the retina. FASEB J. 2016;30:813-23 pubmed publisher
    ..The hormone hepcidin may regulate retinal Fpn, as it triggers Fpn degradation in the gut...
  45. Mastrogiannaki M, Matak P, Delga S, Deschemin J, Vaulont S, Peyssonnaux C. Deletion of HIF-2α in the enterocytes decreases the severity of tissue iron loading in hepcidin knockout mice. Blood. 2012;119:587-90 pubmed publisher
    ..HH is caused by mutations in the genes encoding upstream regulators of hepcidin or more rarely in the hepcidin gene itself...
  46. Moroishi T, Nishiyama M, Takeda Y, Iwai K, Nakayama K. The FBXL5-IRP2 axis is integral to control of iron metabolism in vivo. Cell Metab. 2011;14:339-51 pubmed publisher
    ..The liver-specific mutant mice died with acute liver failure when fed a high-iron diet. Thus, our results uncover a major role for FBXL5 in ensuring an appropriate supply of iron to cells. ..
  47. Tjalsma H, Laarakkers C, van Swelm R, Theurl M, Theurl I, Kemna E, et al. Mass spectrometry analysis of hepcidin peptides in experimental mouse models. PLoS ONE. 2011;6:e16762 pubmed publisher
    The mouse is a valuable model for unravelling the role of hepcidin in iron homeostasis, however, such studies still report hepcidin mRNA levels as a surrogate marker for bioactive hepcidin in its pivotal function to block ferroportin-..
  48. Pasricha S, Lim P, Duarte T, Casu C, Oosterhuis D, Mleczko Sanecka K, et al. Hepcidin is regulated by promoter-associated histone acetylation and HDAC3. Nat Commun. 2017;8:403 pubmed publisher
    b>Hepcidin regulates systemic iron homeostasis. Suppression of hepcidin expression occurs physiologically in iron deficiency and increased erythropoiesis but is pathologic in thalassemia and hemochromatosis...
  49. Yoon D, Pastore Y, Divoky V, Liu E, Mlodnicka A, Rainey K, et al. Hypoxia-inducible factor-1 deficiency results in dysregulated erythropoiesis signaling and iron homeostasis in mouse development. J Biol Chem. 2006;281:25703-11 pubmed
    ..profound defects in iron homeostasis, Hif1alpha-/- yolk sac and/or embryos demonstrated aberrant mRNA levels of hepcidin, Fpn1, Irp1, and frascati...
  50. Ginzburg Y, Rybicki A, Suzuka S, Hall C, Breuer W, Cabantchik Z, et al. Exogenous iron increases hemoglobin in beta-thalassemic mice. Exp Hematol. 2009;37:172-83 pubmed publisher
    ..Patients with beta-thalassemia develop iron overload, despite which, hepcidin levels are low...
  51. Liu Q, Davidoff O, Niss K, Haase V. Hypoxia-inducible factor regulates hepcidin via erythropoietin-induced erythropoiesis. J Clin Invest. 2012;122:4635-44 pubmed publisher
    ..b>Hepcidin, a small polypeptide produced by hepatocytes, plays a central role in regulating iron uptake by promoting ..
  52. Tselepis C, Ford S, McKie A, Vogel W, Zoller H, Simpson R, et al. Characterization of the transition-metal-binding properties of hepcidin. Biochem J. 2010;427:289-96 pubmed publisher
    Accumulating evidence suggests that hepcidin, a 25-residue peptide hormone, is the master regulator of iron metabolism. Further evidence suggests that the five N-terminal amino acids are crucial for mediating its biological function...
  53. Wu X, Wang Y, Wu Q, Cheng W, Liu W, Zhao Y, et al. HFE interacts with the BMP type I receptor ALK3 to regulate hepcidin expression. Blood. 2014;124:1335-43 pubmed publisher
    ..HFE mutations result in reduced expression of hepcidin, a hepatic hormone, which negatively regulates iron absorption from the duodenum and iron release from ..
  54. Casu C, Oikonomidou P, Chen H, Nandi V, Ginzburg Y, Prasad P, et al. Minihepcidin peptides as disease modifiers in mice affected by β-thalassemia and polycythemia vera. Blood. 2016;128:265-76 pubmed publisher
    ..Minihepcidins are hepcidin agonists that have been previously shown to prevent iron overload in murine models of hemochromatosis and induce ..
  55. Smith C, Arvedson T, Cooke K, Dickmann L, Forte C, Li H, et al. IL-22 regulates iron availability in vivo through the induction of hepcidin. J Immunol. 2013;191:1845-55 pubmed publisher
    ..Physiological regulation of iron stores is of critical importance for RBC production and antimicrobial defense. Hepcidin is a key regulator of iron levels within the body...
  56. McCranor B, Langdon J, Prince O, Femnou L, Berger A, Cheadle C, et al. Investigation of the role of interleukin-6 and hepcidin antimicrobial peptide in the development of anemia with age. Haematologica. 2013;98:1633-40 pubmed publisher
    ..that interleukin-6 contributes to this anemia, given its pro-inflammatory activities, its ability to induce hepcidin antimicrobial peptide, and its negative impact on several tissues in older adults...
  57. Lakhal Littleton S, Wolna M, Carr C, Miller J, Christian H, Ball V, et al. Cardiac ferroportin regulates cellular iron homeostasis and is important for cardiac function. Proc Natl Acad Sci U S A. 2015;112:3164-9 pubmed publisher
    ..We then compared their phenotype with that of ubiquitous hepcidin knockouts, a recognized model of the iron-loading disease hemochromatosis...
  58. Canali S, Vecchi C, Garuti C, Montosi G, Babitt J, Pietrangelo A. The SMAD Pathway Is Required for Hepcidin Response During Endoplasmic Reticulum Stress. Endocrinology. 2016;157:3935-3945 pubmed
    b>Hepcidin, the iron hormone, is regulated by a number of stimulatory and inhibitory signals. The cAMP responsive element binding protein 3-like 3 (CREB3L3) mediates hepcidin response to endoplasmic reticulum (ER) stress...
  59. Preza G, Ruchala P, Pinon R, Ramos E, Qiao B, Peralta M, et al. Minihepcidins are rationally designed small peptides that mimic hepcidin activity in mice and may be useful for the treatment of iron overload. J Clin Invest. 2011;121:4880-8 pubmed publisher
    ..Iron overload in hereditary hemochromatosis and β-thalassemia intermedia is caused by hepcidin deficiency...
  60. Hadziahmetovic M, Song Y, Wolkow N, Iacovelli J, Kautz L, Roth M, et al. Bmp6 regulates retinal iron homeostasis and has altered expression in age-related macular degeneration. Am J Pathol. 2011;179:335-48 pubmed publisher
    ..Intraocular Bmp6 protein injection in mice up-regulated retinal hepcidin, an iron regulatory hormone, and altered retinal labile iron levels...
  61. Vecchi C, Montosi G, Garuti C, Corradini E, Sabelli M, Canali S, et al. Gluconeogenic signals regulate iron homeostasis via hepcidin in mice. Gastroenterology. 2014;146:1060-9 pubmed publisher
    ..We investigated whether gluconeogenic signals directly control Hepcidin, an important regulator of iron homeostasis, in starving mice (a model of persistently activated gluconeogenesis ..
  62. Nai A, Pagani A, Mandelli G, Lidonnici M, Silvestri L, Ferrari G, et al. Deletion of TMPRSS6 attenuates the phenotype in a mouse model of β-thalassemia. Blood. 2012;119:5021-9 pubmed publisher
    Inappropriately low expression of the key iron regulator hepcidin (HAMP) causes iron overload in untransfused patients affected by β-thalassemia intermedia and Hamp modulation provides improvement of the thalassemic phenotype of the Hbb(..