Gene Symbol: Hadh
Description: hydroxyacyl-Coenzyme A dehydrogenase
Alias: AA409008, AU019341, AW742602, HCDH, Hadhsc, Schad, hydroxyacyl-coenzyme A dehydrogenase, mitochondrial, L-3-hydroxyacyl-Coenzyme A dehydrogenase, short chain, hydroxylacyl-Coenzyme A dehydrogenase-dehydrogenase, medium and short chain L-3-hydroxyacyl-coenzyme A dehydrogenase, short-chain 3-hydroxyacyl-CoA dehydrogenase
Nomura M, Takihara Y, Shimada K. Isolation and characterization of retinoic acid-inducible cDNA clones in F9 cells: one of the early inducible clones encodes a novel protein sharing several highly homologous regions with a Drosophila polyhomeotic protein. Differentiation. 1994;57:39-50 pubmed
..As the Drosophila polyhomeotic gene is involved in regulating morphogenesis, the rae-28 gene may participate in regulating early mammalian development...
Hardy O, Hohmeier H, Becker T, Manduchi E, Doliba N, Gupta R, et al
. Functional genomics of the beta-cell: short-chain 3-hydroxyacyl-coenzyme A dehydrogenase regulates insulin secretion independent of K+ currents. Mol Endocrinol. 2007;21:765-73 pubmed
..Among the genes identified was Hadhsc, which encodes short-chain 3-hydroxyacyl-coenzyme A dehydrogenase (SCHAD), an enzyme of mitochondrial beta-..
Li C, Chen P, Palladino A, Narayan S, Russell L, Sayed S, et al
. Mechanism of hyperinsulinism in short-chain 3-hydroxyacyl-CoA dehydrogenase deficiency involves activation of glutamate dehydrogenase. J Biol Chem. 2010;285:31806-18 pubmed publisher
..with hyperinsulinism associated with inactivating mutations of short-chain 3-hydroxyacyl-CoA dehydrogenase (SCHAD) was examined in mice with a knock-out of the hadh gene (hadh(-/-))...
Nomura M, Takihara Y, Shimada K. Isolation of a cDNA clone encoding mouse 3-hydroxyacyl CoA dehydrogenase. Gene. 1995;160:309-10 pubmed
..cells, was sequenced, and the deduced RAE-38 protein showed about 86% homology to pig 3-hydroxyacyl CoA dehydrogenase (HCDH; EC 188.8.131.52). This clone can be used to elucidate the regulatory mechanism of HCDH gene expression in mammals.
Tieu K, Perier C, Vila M, Caspersen C, Zhang H, Teismann P, et al
. L-3-hydroxyacyl-CoA dehydrogenase II protects in a model of Parkinson's disease. Ann Neurol. 2004;56:51-60 pubmed
..Here, we report that L-3-hydroxyacyl-CoA dehydrogenase type II/amyloid binding alcohol dehydrogenase (HADH II/ABAD), a mitochondrial oxidoreductase enzyme involved in neuronal survival, is downregulated in PD patients and ..
Schulz N, Himmelbauer H, Rath M, van Weeghel M, Houten S, Kulik W, et al
. Role of medium- and short-chain L-3-hydroxyacyl-CoA dehydrogenase in the regulation of body weight and thermogenesis. Endocrinology. 2011;152:4641-51 pubmed publisher
..Medium- and short-chain-3-hydroxyacyl-coenzyme A (CoA) dehydrogenase (SCHAD) (gene name, hadh) catalyze the third reaction of the mitochondrial ?-oxidation cascade, the oxidation of 3-..
Narayan S, Master S, Sireci A, Bierl C, Stanley P, Li C, et al
. Short-chain 3-hydroxyacyl-coenzyme A dehydrogenase associates with a protein super-complex integrating multiple metabolic pathways. PLoS ONE. 2012;7:e35048 pubmed publisher
..We previously described an interaction between short-chain 3-hydroxyacyl-coenzyme A dehydrogenase (SCHAD) and glutamate dehydrogenase (GDH) explaining the clinical phenotype of hyperinsulinism in SCHAD-deficient ..
Molven A, Hollister Lock J, Hu J, Martinez R, NjÃ¸lstad P, Liew C, et al
. The Hypoglycemic Phenotype Is Islet Cell-Autonomous in Short-Chain Hydroxyacyl-CoA Dehydrogenase-Deficient Mice. Diabetes. 2016;65:1672-8 pubmed publisher
..CHI) can be caused by inactivating mutations in the gene encoding short-chain 3-hydroxyacyl-CoA dehydrogenase (SCHAD), a ubiquitously expressed enzyme involved in fatty acid oxidation...
Shekhawat P, Yang H, Bennett M, Carter A, Matern D, Tamai I, et al
. Carnitine content and expression of mitochondrial beta-oxidation enzymes in placentas of wild-type (OCTN2(+/+)) and OCTN2 Null (OCTN2(-/-)) Mice. Pediatr Res. 2004;56:323-8 pubmed
..at comparable levels in wild-type (OCTN2(+/+)) and homozygous (OCTN2(-/-)) mouse placentas, with the exception of SCHAD, for which activity was significantly higher in OCTN2(-/-) placentas than in OCTN2(+/+) placentas...