Gene Symbol: Hacl1
Description: 2-hydroxyacyl-CoA lyase 1
Alias: 1600020H07Rik, Hpcl, Phyh2, 2-hydroxyacyl-CoA lyase 1, 2-HPCL, 2-hydroxyphytanoyl-CoA lyase, phytanoyl-CoA 2-hydroxylase 2
Species: mouse
Products:     Hacl1

Top Publications

  1. Foulon V, Sniekers M, Huysmans E, Asselberghs S, Mahieu V, Mannaerts G, et al. Breakdown of 2-hydroxylated straight chain fatty acids via peroxisomal 2-hydroxyphytanoyl-CoA lyase: a revised pathway for the alpha-oxidation of straight chain fatty acids. J Biol Chem. 2005;280:9802-12 pubmed
    ..e. the breakdown of 2-hydroxyfatty acids, at least the long chain 2-hydroxyfatty acids. Most likely, the more abundant very long chain 2-hydroxyfatty acids are degraded in a similar manner. ..
  2. Mezzar S, De Schryver E, Van Veldhoven P. RP-HPLC-fluorescence analysis of aliphatic aldehydes: application to aldehyde-generating enzymes HACL1 and SGPL1. J Lipid Res. 2014;55:573-82 pubmed publisher
    ..The enzymes involved in the aldehyde-generating steps of these processes are 2-hydroxyacyl-CoA lyase (HACL1) and sphingosine-1-phosphate lyase (SGPL1), respectively...
  3. Huyghe S, Casteels M, Janssen A, Meulders L, Mannaerts G, Declercq P, et al. Prenatal and postnatal development of peroxisomal lipid-metabolizing pathways in the mouse. Biochem J. 2001;353:673-80 pubmed