Gene Symbol: H2-M3
Description: histocompatibility 2, M region locus 3
Alias: H-2M3, Hmt, M3a, MuprM3, MuprM301, MuprM302, R4B2, histocompatibility 2, M region locus 3, MHC class I-b antigen M3
Species: mouse
Products:     H2-M3

Top Publications

  1. Chiu N, Chun T, Fay M, Mandal M, Wang C. The majority of H2-M3 is retained intracellularly in a peptide-receptive state and traffics to the cell surface in the presence of N-formylated peptides. J Exp Med. 1999;190:423-34 pubmed
    ..The nonpolymorphic nature of M3 and its ability to present bacterial antigens rapidly and dominantly make it an attractive target for peptide vaccination strategies...
  2. Wang C, Lindahl K. HMT, encoded by H-2M3, is a neoclassical major histocompatibility class I antigen. Proc Natl Acad Sci U S A. 1993;90:2784-8 pubmed
    H-2M3 encodes HMT, the major histocompatibility complex (MHC) class I heavy chain of the maternally transmitted antigen (Mta)...
  3. Xu H, Chun T, Choi H, Wang B, Wang C. Impaired response to Listeria in H2-M3-deficient mice reveals a nonredundant role of MHC class Ib-specific T cells in host defense. J Exp Med. 2006;203:449-59 pubmed
    ..Thus, the early H2-M3-restricted response temporally bridges the gap between innate and adaptive immune responses, subsequently affecting the function of both branches of the immune system. ..
  4. Lindahl K, Hausmann B, Chapman V. A new H-2-linked class I gene whose expression depends on a maternally inherited factor. Nature. 1983;306:383-5 pubmed
    ..We now show that a gene, Hmt, closely linked to the H-2 complex, is also required for expression of Mta.
  5. Wang C, Loveland B, Lindahl K. H-2M3 encodes the MHC class I molecule presenting the maternally transmitted antigen of the mouse. Cell. 1991;66:335-45 pubmed
    ..M3 is as divergent from classical, antigen-presenting H-2 molecules as from other class I genes of the Hmt and the Qa/Tla regions. Amino acids critical for folding of class I molecules are conserved in M3...
  6. Lybarger L, Yu Y, Chun T, Wang C, Grandea A, van Kaer L, et al. Tapasin enhances peptide-induced expression of H2-M3 molecules, but is not required for the retention of open conformers. J Immunol. 2001;167:2097-105 pubmed
    ..Unexpectedly, peptide-induced surface expression of M3 was observed in only one of two cell lines. These results demonstrate that M3 expression is dependent on a unique factor compared with class Ia molecules...
  7. Ugrinovic S, Brooks C, Robson J, Blacklaws B, Hormaeche C, Robinson J. H2-M3 major histocompatibility complex class Ib-restricted CD8 T cells induced by Salmonella enterica serovar Typhimurium infection recognize proteins released by Salmonella serovar Typhimurium. Infect Immun. 2005;73:8002-8 pubmed
    ..It also expands the range of pathogens that induce H2-M3-restricted CD8 T cells to include an example of gram-negative bacteria. ..
  8. Bediako Y, Bian Y, Zhang H, Cho H, Stein P, Wang C. SAP is required for the development of innate phenotype in H2-M3--restricted Cd8(+) T cells. J Immunol. 2012;189:4787-96 pubmed publisher
  9. Andrews D, Sullivan L, Baschuk N, Chan C, Berry R, Cotterell C, et al. Recognition of the nonclassical MHC class I molecule H2-M3 by the receptor Ly49A regulates the licensing and activation of NK cells. Nat Immunol. 2012;13:1171-7 pubmed publisher
    ..Thus, nonclassical MHC class I molecules can act as cognate ligands for Ly49 molecules. Our results provide insight into the various mechanisms that lead to NK cell tolerance. ..

More Information


  1. Richards S, Bucan M, Brorson K, Kiefer M, Hunt S, Lehrach H, et al. Genetic and molecular mapping of the Hmt region of mouse. EMBO J. 1989;8:3749-57 pubmed
    ..A novel MHC class I gene fragment, R4B2, was cloned and mapped to this region as was another new class I gene, Thy19.4...
  2. Swanson P, Pack C, Hadley A, Wang C, Stroynowski I, Jensen P, et al. An MHC class Ib-restricted CD8 T cell response confers antiviral immunity. J Exp Med. 2008;205:1647-57 pubmed publisher
  3. Cho H, Bediako Y, Xu H, Choi H, Wang C. Positive selecting cell type determines the phenotype of MHC class Ib-restricted CD8+ T cells. Proc Natl Acad Sci U S A. 2011;108:13241-6 pubmed publisher
    ..Our results suggest that these two distinct populations may allow MHC class Ib-restricted CD8(+) T cells to occupy different immunological niches playing unique roles in immune responses to infection. ..
  4. Braud V, Allan D, McMichael A. Functions of nonclassical MHC and non-MHC-encoded class I molecules. Curr Opin Immunol. 1999;11:100-8 pubmed
  5. Lamp K, Humeny A, Nikolic Z, Imai K, Adamski J, Schiebel K, et al. The murine GABA(B) receptor 1: cDNA cloning, tissue distribution, structure of the Gabbr1 gene, and mapping to chromosome 17. Cytogenet Cell Genet. 2001;92:116-21 pubmed
    ..Radiation hybrid mapping, combined with database searches, indicated that the GABA(B) receptor gene (Gabbr1) is located on mouse chromosome 17, adjacent to the marker D17Mit24 in a region homologous to human chromosome 6p21.3. ..
  6. Cho H, Choi H, Xu H, Felio K, Wang C. Nonconventional CD8+ T cell responses to Listeria infection in mice lacking MHC class Ia and H2-M3. J Immunol. 2011;186:489-98 pubmed publisher
    ..These data demonstrate that other MHC class Ib-restricted CD8(+) T cells, in addition to H2-M3-restricted T cells, contribute to antilisterial immunity and may contribute to immune responses against other intracellular bacteria. ..
  7. D Orazio S, Shaw C, Starnbach M. H2-M3-restricted CD8+ T cells are not required for MHC class Ib-restricted immunity against Listeria monocytogenes. J Exp Med. 2006;203:383-91 pubmed
    ..These data suggest that M3-restricted T cells are not required for protection against L. monocytogenes and underscore the importance of searching for new antigen-presenting molecules among the large MHC-Ib family of proteins. ..
  8. Johnson L, Weizman O, Rapp M, Way S, Sun J. Epitope-Specific Vaccination Limits Clonal Expansion of Heterologous Naive T Cells during Viral Challenge. Cell Rep. 2016;17:636-644 pubmed publisher
    ..These findings have important implications in pathogen vaccination strategies that depend on the targeting of multiple T cell epitopes. ..
  9. Hughes A, Yeager M, Ten Elshof A, Chorney M. A new taxonomy of mammalian MHC class I molecules. Immunol Today. 1999;20:22-6 pubmed
  10. Brorson K, Richards S, Hunt S, Cheroutre H, Lindahl K, Hood L. Analysis of a new class I gene mapping to the Hmt region of the mouse. Immunogenetics. 1989;30:273-83 pubmed
    ..However, unlike the classical class I genes, the Thy19.4 gene maps approximately 1 cm distal to the Tla region of the MHC, in the same region as the gene encoding the Hmt element of the maternally transmitted antigen.
  11. Ito K, van Kaer L, Bonneville M, Hsu S, Murphy D, Tonegawa S. Recognition of the product of a novel MHC TL region gene (27b) by a mouse gamma delta T cell receptor. Cell. 1990;62:549-61 pubmed
    ..We propose that gamma delta TCR and nonclassical MHC and MHC-related class I molecules have coevolved to recognize a conserved set of endogenous and foreign determinants. ..
  12. Pham Dinh D, Mattei M, Nussbaum J, Roussel G, Pontarotti P, Roeckel N, et al. Myelin/oligodendrocyte glycoprotein is a member of a subset of the immunoglobulin superfamily encoded within the major histocompatibility complex. Proc Natl Acad Sci U S A. 1993;90:7990-4 pubmed
    ..We colocalized the MOG and BT genes to the human MHC on chromosome 6p21.3-p22. The mouse MOG gene was mapped to the homologous band C of chromosome 17, within the M region of the mouse MHC. ..
  13. Wang C, Lambracht D, Wonigeit K, Howard J, Lindahl K. Rat RT1 orthologs of mouse H2-M class Ib genes. Immunogenetics. 1995;42:63-7 pubmed
  14. Lindahl K, Hausmann B, Robinson P, Guenet J, Wharton D, Winking H. Mta, the maternally transmitted antigen, is determined jointly by the chromosomal Hmt and the extrachromosomal Mtf genes. J Exp Med. 1986;163:334-46 pubmed
    ..appropriate crosses with inbred mice showed that the spretus form of Mta is determined by a new allele, c, of the Hmt gene. The Hmtc allele has been isolated in coupling with four different H-2 haplotypes...
  15. Doyle C, Davis B, Cook R, Rich R, Rodgers J. Hyperconservation of the N-formyl peptide binding site of M3: evidence that M3 is an old eutherian molecule with conserved recognition of a pathogen-associated molecular pattern. J Immunol. 2003;171:836-44 pubmed
    ..Such MHC PRR molecules could have been preadaptations for the evolution of acquired immunity during the early vertebrate radiation. ..
  16. Chow M, Dhanji S, Cross J, Johnson P, Teh H. H2-M3-restricted T cells participate in the priming of antigen-specific CD4+ T cells. J Immunol. 2006;177:5098-104 pubmed
    ..These results reveal a novel function for H2-M3- and Qa-1-restricted T cells; provision of help to CD4+ Th cells during the primary response. ..
  17. Tvinnereim A, Wizel B. CD8+ T cell protective immunity against Chlamydia pneumoniae includes an H2-M3-restricted response that is largely CD4+ T cell-independent. J Immunol. 2007;179:3947-57 pubmed
    ..These results suggest that H2-M3-restricted CD8+ T cells contribute to protective immunity against Cpn, and that chlamydial Ags presented by MHC class Ib molecules may represent novel targets for inclusion in anti-Cpn vaccines. ..
  18. Chow M, Teh H. H2-M3-restricted CD8+ T cells augment CD4+ T-cell responses by promoting DC maturation. Eur J Immunol. 2010;40:1408-17 pubmed publisher
    ..This study indicates that H2-M3-restricted T cells promote immune responses by CD4+ T cells by inducing DC maturation and suggests novel mechanisms for vaccine development. ..
  19. Rodgers J, Smith R, Huston M, Rich R. Maternally transmitted antigen. Adv Immunol. 1986;38:313-59 pubmed
  20. Martínez Naves E, Lafuente E, Reche P. Recognition of the ligand-type specificity of classical and non-classical MHC I proteins. FEBS Lett. 2011;585:3478-84 pubmed publisher
    ..Moreover, we applied these classifiers to human and mouse MHC I proteins of uncharacterized ligands, obtaining some results that can be instrumental to unravel the function of these proteins. ..
  21. Chen L, Jay D, Fairbanks J, He X, Jensen P. An MHC class Ib-restricted CD8+ T cell response to lymphocytic choriomeningitis virus. J Immunol. 2011;187:6463-72 pubmed publisher
    ..These findings demonstrate that class Ib-restricted CD8(+) T cells have the potential to participate in the host immune response to LCMV. ..
  22. Gunther E, Walter L. Comparative genomic aspects of rat, mouse and human MHC class I gene regions. Cytogenet Cell Genet. 2000;91:107-12 pubmed
    ..In this review a particular aspect of the genomic structure of the major histocompatibility complex (MHC), the organization of MHC class I regions, will be discussed for the rat in comparison to mouse and human. ..
  23. Jones E, Xiao H, Schultz R, Flaherty L, Trachtulec Z, Vincek V, et al. MHC class I gene organization in > 1.5-Mb YAC contigs from the H2-M region. Genomics. 1995;27:40-51 pubmed
  24. Liu J, Shen Y, Li M, Lv D, Zhang A, Peng Y, et al. Spatial-Temporal Expression of Non-classical MHC Class I Molecules in the C57 Mouse Brain. Neurochem Res. 2015;40:1487-96 pubmed publisher
    ..The elucidation and discovery of the expression profile of MHC class I molecules during development is important for supporting an enhanced understanding of their physiological and potential pathological roles within the CNS. ..