Genomes and Genes
Gene Symbol: H2-Ab1
Description: histocompatibility 2, class II antigen A, beta 1
Alias: AI845868, Abeta, H-2Ab, H2-Ab, I-Abeta, IAb, Ia-2, Ia2, Rmcs1, H-2 class II histocompatibility antigen, A beta chain, MHC class II H2-IA-beta-psi, MHC class II antigen A beta, major histocompatibility complex class II beta chain, response to metastatic cancers 1
Publications130 found, 100 shown here
- Dendritic cells regulate exposure of MHC class II at their plasma membrane by oligoubiquitinationGuillaume van Niel
Faculty of Veterinary Medicine, Department of Biochemistry and Cell Biology, Utrecht University, P O Box 80 176, NL 3508 TD, Utrecht, The Netherlands
Immunity 25:885-94. 2006..Together, these data provide a molecular basis for the regulation of MHC class II-mediated antigen presentation by DCs...
- Role of CD4 T cell help and costimulation in CD8 T cell responses during Listeria monocytogenes infectionDevon J Shedlock
Department of Microbiology, School of Medicine, University of Pennsylvania, 3610 Hamilton Walk, Philadelphia, PA 19104 6076, USA
J Immunol 170:2053-63. 2003....
- CD8+ cells enhance resistance to pulmonary serotype 3 Streptococcus pneumoniae infection in miceSarah E Weber
Department of Microbiology and Immunology, Albert Einstein College of Medicine, Bronx, NY 10461, USA
J Immunol 186:432-42. 2011....
- Mice lacking all conventional MHC class II genesL Madsen
Department of Clinical Immunology, Rigshospitalet, 2200 Copenhagen, Denmark
Proc Natl Acad Sci U S A 96:10338-43. 1999..These mice feature immune system perturbations like those of Aalpha and Abeta knockout animals, notably a dearth of CD4(+) lymphocytes in the thymus and spleen...
- Major histocompatibility complex class I molecules are required for the development of insulitis in non-obese diabetic miceJ Katz
Laboratoire de Genetique Moleculaire des Eucaryotes du CNRS, Strasbourg, France
Eur J Immunol 23:3358-60. 1993..We question this interpretation because NOD mice lacking MHC class I molecules, hence CD8+ T cells, do not display even insulitis when expected...
- Expansion of peripheral naturally occurring T regulatory cells by Fms-like tyrosine kinase 3 ligand treatmentLee Kim Swee
Departement Biomedizin Basel, University of Basel, Switzerland
Blood 113:6277-87. 2009..It also reinforces the relevance of FLT3L treatment in GVHD by its ability to increase both the number of tolerizing DCs and NTregs...
- Mice lacking major histocompatibility complex class I and class II moleculesM J Grusby
Department of Cancer Biology, Harvard School of Public Health, Boston, MA 02115
Proc Natl Acad Sci U S A 90:3913-7. 1993..Taken together, these results emphasize the plasticity of the immune system and suggest that MHC-deficient mice may be useful for examining compensatory mechanisms in severely immunocompromised animals...
- Characterization of the early stages of thymic NKT cell developmentKamel Benlagha
Committee on Immunology, The University of Chicago, Chicago, IL 60637, USA
J Exp Med 202:485-92. 2005..1neg CD4 cells. These findings identify the HSAhigh CD4+ stage as a potential branchpoint between NKT and conventional T lineages and between the CD4 and DN NKT sublineages...
- Major DQ8-restricted T-cell epitopes for human GAD65 mapped using human CD4, DQA1*0301, DQB1*0302 transgenic IA(null) NOD miceJ Liu
Department of Medical Microbiology and Immunology, University of Alberta, Edmonton, Canada
Diabetes 48:469-77. 1999....
- The mouse CD1d-restricted repertoire is dominated by a few autoreactive T cell receptor familiesS H Park
Department of Molecular Biology, Princeton University, Princeton, New Jersey 08544, USA
J Exp Med 193:893-904. 2001..Altogether, these findings imply that lipid recognition by CD1d-restricted T cells may have largely evolved as an innate rather than an adaptive arm of the mouse immune system...
- The repertoire of T cells shaped by a single MHC/peptide ligandL Ignatowicz
Department of Medicine, National Jewish Center for Immunology and Respiratory Medicine, University of Colorado Health Sciences Center, Denver, 80206, USA
Cell 84:521-9. 1996..T cells that mature in thymuses expressing a single MHC/peptide ligand react frequently with foreign MHC, suggesting that the repertoire of alpha beta receptors may be more biased toward reaction with MHC than was previously thought...
- Mice lacking H2-M complexes, enigmatic elements of the MHC class II peptide-loading pathwayT Miyazaki
Institut de Genetique et de Biologie Moleculaire et Cellulaire, Universite Louis Pasteur, France
Cell 84:531-41. 1996..Peripheral T cells reacted strongly to splenocytes from syngeneic wild-type mice, no doubt reflecting the unique peptide complement carried by class II molecules in mutant animals...
- H2-M mutant mice are defective in the peptide loading of class II molecules, antigen presentation, and T cell repertoire selectionW D Martin
Howard Hughes Medical Institute, Department of Microbiology and Immunology, Vanderbilt University School of Medicine, Nashville, Tennessee 37232, USA
Cell 84:543-50. 1996..Overall, this phenotype establishes an important role for H2-M in regulating MHC class II function in vivo and supports the notion that self-peptides contribute to the specificity of T cell positive selection...
- Organ-specific regulation of the CD8 T cell response to Listeria monocytogenes infectionC Pope
Division of Rheumatic Diseases, University of Connecticut Health Center, Farmington, CT 06030, USA
J Immunol 166:3402-9. 2001..Overall, the results point to novel pathways of tissue-specific regulation of primary and memory antimicrobial CD8 T cell responses...
- Antigen presentation and T cell development in H2-M-deficient miceW P Fung-Leung
R W Johnson Pharmaceutical Research Institute, San Diego, CA 92121, USA
Science 271:1278-81. 1996..Their CD4+ cells were unresponsive to self H2-M-deficient antigen-presenting cells (APCs) but were hyperreactive to wild-type APCs. H2-M-deficient APCs failed to elicit proliferative responses from wild-type T cells...
- A conditional null allele of the major histocompatibility IA-beta chain geneKahoko Hashimoto
Institute of Molecular Medicine and Genetics and Department of Medicine, Medical College of Georgia, Augusta, Georgia 30912, USA
Genesis 32:152-3. 2002
- IL-2 receptor beta-dependent STAT5 activation is required for the development of Foxp3+ regulatory T cellsMatthew A Burchill
Department of Laboratory Medicine and Pathology, University of Minnesota, Minneapolis, MN 55455, USA
J Immunol 178:280-90. 2007..Finally, STAT5 binds to the promoter of the foxp3 gene suggesting that IL-2Rbeta-dependent STAT5 activation promotes Treg differentiation by regulating expression of foxp3...
- The cytoplasmic domain of CD4 promotes the development of CD4 lineage T cellsA Itano
Department of Molecular and Cell Biology, University of California, Berkeley, 94720, USA
J Exp Med 183:731-41. 1996..We discuss these results in terms of current models for CD4 and CD8 lineage commitment...
- Conditional ablation of MHC-II suggests an indirect role for MHC-II in regulatory CD4 T cell maintenanceMichiko Shimoda
Molecular Immunology Program and Immunotherapy Center, Medical College of Georgia, Augusta, GA 30912, USA
J Immunol 176:6503-11. 2006..Thus, our findings lend support to the proposal that Treg cell homeostasis depends on a delicate balance with a population of self-reactive IL-2-producing CD4+CD25+ cells which are themselves at least in part MHC-II-dependent...
- HLA-DR4-IE chimeric class II transgenic, murine class II-deficient mice are susceptible to experimental allergic encephalomyelitisK Ito
Department of Inflammation and Autoimmune Diseases, Hoffmann La Roche Inc, Nutley, New Jersey 07110, USA
J Exp Med 183:2635-44. 1996..Non-Tg mice immunized with either PLP175-192 or MBP87-106 did not develop EAE. These results demonstrated that a human MHC class II binding site alone can confer susceptibility to an experimentally induced murine autoimmune disease...
- Mice lacking the MHC class II-associated invariant chainS Viville
Laboratorie de Génétique Moléculaire des Eucaryotes du CNRS, Strasbourg, France
Cell 72:635-48. 1993..Consequently, mutant cells present protein antigens very poorly and mutant mice are deficient in producing and at negatively selecting CD4+ T cells...
- Epistatic suppression of systemic lupus erythematosus: fine mapping of Sles1 to less than 1 mbSrividya Subramanian
Center for Immunology and Department of Pathology, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, TX 75390, USA
J Immunol 175:1062-72. 2005..Sle1 Sles1)F(1)s. These findings localize and characterize the suppressive properties of Sles1 and implicate 129 as a useful strain for aiding in the identification of this elusive epistatic modifier gene...
- Depletion of CD4+ T cells in major histocompatibility complex class II-deficient miceM J Grusby
Department of Cancer Biology, Harvard School of Public Health, Boston, MA
Science 253:1417-20. 1991..These results provide genetic evidence that class II molecules are required for the maturation and function of mature CD4+ T cells...
- CD8alpha+ and CD11b+ dendritic cell-restricted MHC class II controls Th1 CD4+ T cell immunityMaria P Lemos
Department of Medicine, University of Pennsylvania, Philadelphia PA 19104, USA
J Immunol 171:5077-84. 2003..These findings indicate that DCs are not only key initiators of the primary response, but provide all of the necessary cognate interactions to control CD4(+) T cell fate during the primary immune response...
- The first external domain of the nonobese diabetic mouse class II I-A beta chain is uniqueH Acha-Orbea
Proc Natl Acad Sci U S A 84:2435-9. 1987..We suggest that the unique structure of the first external I-A beta chain domain is a major determinant in the disease susceptibility that maps to the major histocompatibility complex of the nonobese diabetic mouse...
- The NOD mouse: recessive diabetogenic gene in the major histocompatibility complexM Hattori
Science 231:733-5. 1986..In crosses of NOD mice with control C3H mice, the development of diabetes was dependent on homozygosity for the NOD mouse's unique major histocompatibility region...
- Characterization of HLA DR2 and DQ8 transgenic mouse with a new engineered mouse class II deletion, which lacks all endogenous class II genesS Cheng
Department of Immunology, Mayo Clinic, 200 First Street SW, Rochester, MN 55905, USA
J Autoimmun 21:195-9. 2003..However, these mice carry the functional mouse Eb gene from the Abeta(0/0) construct and could express Ebeta/DRalpha(Ealpha) molecules and shape the T cell repertoire in these mice...
- Nonself-antigens are the cognate specificities of Foxp3+ regulatory T cellsRafal Pacholczyk
Center for Biotechnology and Genomic Medicine, Medical College of Georgia, Augusta, GA 30912, USA
Immunity 27:493-504. 2007..Our results show that high-affinity, autoreactive TCRs are rare on all CD4+ T cells and suggest that selecting self-peptide is different from the peptide that activates the same regulatory T cells in the periphery...
- On the role of MHC class II molecules in the survival and lymphopenia-induced proliferation of peripheral CD4+ T cellsBruno Martin
Institut National de la Santé et de la Recherche Médicale U561, Hopital Saint Vincent de Paul, 75014 Paris, France
Proc Natl Acad Sci U S A 100:6021-6. 2003..Nevertheless, interactions with classical MHC class II molecules are required for CD4(+) T cells to survive in CD8(+) T-cell-containing mice...
- Dual functions of Runx proteins for reactivating CD8 and silencing CD4 at the commitment process into CD8 thymocytesTakehito Sato
Department of Immunology, Tokai University School of Medicine, Boseidai, Isehara, Kanagawa 259 1193, Japan
Immunity 22:317-28. 2005....
- HLA-DQ determines the response to exogenous wheat proteins: a model of gluten sensitivity in transgenic knockout miceKay E Black
Department of Immunology, Division of Gastroenterology and Hepatology, Mayo Clinic and Foundation, 220 1st Street SW, Rochester, MN 55905, USA
J Immunol 169:5595-600. 2002..These data suggest that this HLA class II transgenic murine model of gluten sensitivity may provide insight into the initiation of the MHC class II-restricted gluten sensitivity in celiac disease...
- Compromised influenza virus-specific CD8(+)-T-cell memory in CD4(+)-T-cell-deficient miceGabrielle T Belz
Department of Immunology, St Jude Children s Research Hospital, Memphis, Tennessee 38105, USA
J Virol 76:12388-93. 2002..These findings are consistent with mathematical models that predict virus-host dynamics in this, and other, models of infection...
- A reassessment of the effect of activated Notch1 on CD4 and CD8 T cell developmentB J Fowlkes
Laboratory of Cellular and Molecular Immunology, National Institutes of Health, Bethesda, MD 20892, USA
J Immunol 169:1817-21. 2002..We suggest that the discrepancies in previous reports of Notch1IC transgenic mice are due to differences in the propensity of the two different transgenic lines to develop tumors...
- Epigenetic silencing of CD4 in T cells committed to the cytotoxic lineageY R Zou
Molecular Pathogenesis Program, Skirball Institute of Biomolecular Medicine, New York University School of Medicine, New York, New York 10016, USA
Nat Genet 29:332-6. 2001..The epigenetic inheritance of the silenced CD4 locus was not affected by the inhibition of DNA methylation or histone deacetylation, and may thus involve other mechanisms that ensure a stable state of gene expression...
- MHC class II expression restricted to CD8alpha+ and CD11b+ dendritic cells is sufficient for control of Leishmania majorMaria P Lemos
Department of Medicine, University of Pennsylvania, Philadelphia 19104, USA
J Exp Med 199:725-30. 2004..major infection using a mouse model in which MHC II, I-Abeta(b), expression is restricted to CD11b+ and CD8alpha+ dendritic cells (DCs)...
- Functionality of major histocompatibility complex class II molecules in mice doubly deficient for invariant chain and H-2M complexesS Tourne
Institut de Genetique et de Biologie Moleculaire et Cellulaire, Centre National de la Recherche Scientifique, Institut National de la Sante et de la Recherche Medicale, University Louis Pasteur 1, Strasbourg, France
Proc Natl Acad Sci U S A 94:9255-60. 1997....
- Low activation threshold as a mechanism for ligand-independent signaling in pre-T cellsMariëlle C Haks
Division of Basic Sciences, Immunobiology Working Group, Fox Chase Cancer Center, Philadelphia, PA 19111, USA
J Immunol 170:2853-61. 2003..Taken together these data suggest that cell-autonomous, ligand-independent signaling is primarily a property of the thymocytes in which pre-TCR signaling occurs...
- NK1.1+ T cells in the liver arise in the thymus and are selected by interactions with class I molecules on CD4+CD8+ cellsM C Coles
Department of Molecular and Cell Biology and Cancer Research Laboratory, University of California, Berkeley, CA 94720, USA
J Immunol 164:2412-8. 2000..1+ T cells or are induced to proliferate after having left the thymus. The results indicate that NK1.1+ T cells, like conventional T cells, arise in the thymus where they are selected by interactions with restricting molecules...
- In vivo treatment of class II MHC-deficient mice with anti-TCR antibody restores the generation of circulating CD4 T cells and optimal architecture of thymic medullaMariam Nasreen
Division of Experimental Immunology, Institute for Genome Research, University of Tokushima, Tokushima, Japan
J Immunol 171:3394-400. 2003....
- Invariant chain-independent function of H-2M in the formation of endogenous peptide-major histocompatibility complex class II complexes in vivoS Kovats
Department of Immunology, University of Washington School of Medicine, Seattle 98195, USA
J Exp Med 187:245-51. 1998..These findings are consistent with the idea that H-2M functions as a chaperone in the peptide loading of class II molecules in vivo...
- Complete characterization of the expressed immune response genes in Biozzi AB/H mice: structural and functional identity between AB/H and NOD A region moleculesG Y Liu
Cambridge University Department of Pathology, UK
Immunogenetics 37:296-300. 1993
- Antiviral immune responses of mice lacking MHC class II or its associated invariant chainM Battegay
Institute of Experimental Immunology, Department of Pathology, University of Zurich, Switzerland
Cell Immunol 167:115-21. 1996..This suggests that local protein concentrations reached during viral infection in the host are high enough to override the Ii deficiency of antigen-presenting cells in vivo...
- HLA-DQB1 polymorphism determines incidence, onset, and severity of collagen-induced arthritis in transgenic mice. Implications in human rheumatoid arthritisD S Bradley
Department of Immunology, Mayo Clinic and Medical School, Rochester, Minnesota 55905, USA
J Clin Invest 100:2227-34. 1997..These studies support a role for HLA-DQ polymorphism in human RA...
- Mice lacking MHC class II moleculesD Cosgrove
Laboratoire de Genetique Moleculaire des Eucaryotes du CNRS, Unité 184 de Biologie Moléculaire de Génie Génétique de l INSERM, Faculte de Medecine, Strasbourg, France
Cell 66:1051-66. 1991..In short, the class II-negative mice have confirmed some old ideas about lymphocyte differentiation, but have provided some surprises...
- Another view of the selective model of thymocyte selectionS H Chan
Laboratoire de Genetique Moleculaire, Eucaryotes du Centre National de la Recherche Scientifique, Faculte de Medecine, Strasbourg, France
Cell 73:225-36. 1993....
- Class II major histocompatibility complex-deficient mice initially control an infection with Leishmania major but succumb to the diseaseH R Chakkalath
Department of Tropical Public Health, Harvard School of Public Health, Boston, Massachusetts, USA
J Infect Dis 171:1302-8. 1995..major and that in the absence of these cells and molecules, such mice can transiently control infection with L. major but are unable to resolve such infections...
- A role for CD40 expression on CD8+ T cells in the generation of CD8+ T cell memoryChristine Bourgeois
INSERM U345, Institut Necker, 156 rue de Vaugirard, F 75730 Paris Cedex 15, France
Science 297:2060-3. 2002..These results suggest that, like B cells, CD8+ T cells receive CD4 help directly through CD40 and that this interaction is fundamental for CD8+ T cell memory generation...
- Recipient MHC class II expression is required to achieve long-term survival of murine cardiac allografts after costimulatory blockadeA Yamada
Transplantation Unit, Surgical Services, Massachusetts General Hospital, Boston, MA 02114, USA
J Immunol 167:5522-6. 2001..These results suggest that an active CD4(+) response through the indirect pathway is necessary for costimulatory blockade to be effective in prolonging allograft survival...
- Distinct MHC class II molecules are associated on the dendritic cell surface in cholesterol-dependent membrane microdomainsSanjay Khandelwal
Experimental Immunology Branch, NCI, National Institutes of Health, Bethesda, Maryland 20892, USA
J Biol Chem 285:35303-10. 2010....
- Epitope affinity for MHC class I determines helper requirement for CTL primingA Franco
Division of Immunochemistry, La Jolla Institute for Allergy and Immunology, San Diego, CA 92121, USA
Nat Immunol 1:145-50. 2000..Depending on the epitope, one source of help was much more efficient than the other...
- Response of murine gamma delta T cells to the synthetic polypeptide poly-Glu50Tyr50C T Cady
Department of Immunology, National Jewish Medical and Research Center, Denver, CO 80206, USA
J Immunol 165:1790-8. 2000..Direct stimulation by ligands resembling pE50Y50 may thus selectively evoke contributions of gamma delta T cells to the host response...
- Nucleotide sequence of a light chain gene of the mouse I-A subregion: A beta dM Malissen
Science 221:750-4. 1983..Sequence comparisons have been made to other proteins involved in immune responses and the consequent implications for the evolutionary relationships of these genes are discussed...
- Variable hematopoietic graft rejection and graft-versus-host disease in MHC-matched strains of miceThai M Cao
Department of Medicine, Stanford University School of Medicine, Stanford, CA 94305, USA
Proc Natl Acad Sci U S A 100:11571-6. 2003..Our results likely extend to all serologically MHC-matched mouse strains used in modern research and highlight the profound and variable influence that non-MHC genetic determinants can have in dictating outcome after HCT...
- The expression of I-A correlates with the uptake of interferon-gamma by macrophagesA Celada
La Jolla Cancer Research Foundation, CA 92037
Eur J Immunol 19:205-8. 1989....
- Mesenchymal cells are required for functional development of thymic epithelial cellsManami Itoi
Department of Immunology and Microbiology, Meiji University of Oriental Medicine, Hiyoshi cho, Nantan, Kyoto 629 0392, Japan
Int Immunol 19:953-64. 2007..In addition, our data suggest that mesenchymal cells are required to create the thymic microenvironment and to maintain epithelial architecture and function...
- Infection of class II-deficient mice by the DA strain of Theiler's virusL Fiette
Unite des Virus Lents, URA 1157 Centre National de la Recherche Scientifique, Institut Pasteur, France
J Virol 70:4811-5. 1996..However, these foci are smaller and contain fewer demyelinated axons than those observed in susceptible SJL/J or beta2m-/- mice...
- Antigen-presenting dendritic cells rescue CD4-depleted CCR2-/- mice from lethal Histoplasma capsulatum infectionWendy A Szymczak
Division of Infectious Diseases, University of Cincinnati, 231 Albert Sabin Way, Cincinnati, OH 45267, USA
Infect Immun 78:2125-37. 2010..Furthermore, CD4(+) T cells had a deleterious impact on immunity in infected CCR2(-/-) mice...
- Helper requirements for generation of effector CTL to islet beta cell antigensGeorg M N Behrens
Immunology Division, Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria, Australia
J Immunol 172:5420-6. 2004..This provides insight into the helper requirements for adoptive transfer immunotherapy of tumors and suggests key points for inhibition of CTL-mediated autoimmunity...
- Critical role of inducible costimulator signaling in the development of arteriosclerosisHisanori Kosuge
Department of Cardiovascular Medicine, Tokyo Medical and Dental University, 1 5 45, Yushima, Bunkyo ku, Tokyo 113 8519, Japan
Arterioscler Thromb Vasc Biol 26:2660-5. 2006..However, the effect of costimulatory molecules on the formation of neointimal hyperplasia has not been fully elucidated. We examined the role of the ICOS pathway in SMC proliferation...
- Skin-resident murine dendritic cell subsets promote distinct and opposing antigen-specific T helper cell responsesBotond Z Igyarto
Department of Dermatology, Center for Immunology, University of Minnesota, Minneapolis, MN 55455, USA
Immunity 35:260-72. 2011..Langerin(+) dDCs also inhibited the ability of LCs and classic DCs to promote Th17 cell responses. This work demonstrates that skin-resident DC subsets promote distinct and opposing antigen-specific responses...
- Arthritis induced by posttranslationally modified (citrullinated) fibrinogen in DR4-IE transgenic miceJonathan A Hill
Department of Microbiology and Immunology, University of Western Ontario, London, Ontario, Canada, N6A 5C1
J Exp Med 205:967-79. 2008..These observations directly implicate citrullinated fibrinogen as arthritogenic in the context of RA-associated MHC class II molecules...
- Requirements for allergen-induced airway inflammation and hyperreactivity in CD4-deficient and CD4-sufficient HLA-DQ transgenic miceS P Chapoval
Department of Immunology, Mayo Clinic, Rochester, MN 55905, USA
J Allergy Clin Immunol 108:764-71. 2001..Airway inflammation is central to the pathogenesis of allergic asthma, and molecules that mediate this process obviously represent targets for therapy...
- Epigenetic propagation of CD4 expression is established by the Cd4 proximal enhancer in helper T cellsMark M W Chong
The Kimmel Center for Biology and Medicine at the Skirball Institute, New York University School of Medicine, New York, New York 10016, USA
Genes Dev 24:659-69. 2010..Thus, E4(P) is responsible for establishing an epigenetically inherited active Cd4 locus in the helper T-cell lineage. To our knowledge, this is the first genetic demonstration of active transcriptional memory in mammalian cells...
- CD70 signaling is critical for CD28-independent CD8+ T cell-mediated alloimmune responses in vivoAkira Yamada
Transplantation Research Center, Brigham and Women s Hospital and Children s Hospital Boston, Harvard Medical School, Boston, MA 02115, USA
J Immunol 174:1357-64. 2005..These novel findings have important implications for the development of transplantation tolerance-inducing strategies in primates and humans, in which CD8(+) T cell depletion is currently mandatory...
- CCR7 signals are essential for cortex-medulla migration of developing thymocytesTomoo Ueno
Division of Experimental Immunology, Institute for Genome Research, University of Tokushima, 3 18 15 Kuramoto, 770 8503, Japan
J Exp Med 200:493-505. 2004..CCR7-dependent cortex-medulla migration of thymocytes plays a crucial role in medulla formation and neonatal T cell export but is not essential for maturation, survival, negative selection, and adult export of thymocytes...
- Comparison of HLA-DR1-restricted T cell response induced in HLA-DR1 transgenic mice deficient for murine MHC class II and HLA-DR1 transgenic mice expressing endogenous murine MHC class II moleculesAnthony Pajot
Unité d Immunité Cellulaire Antivirale, INSERM U370, Institut Pasteur, Paris, France
Int Immunol 16:1275-82. 2004..Thus, HLA-DR1+/+/IAbeta0/0 mice represent a better model for identifying and characterizing HLA-DR1-restricted epitopes relevant for human disease...
- Dichotomous effects of complete versus partial class II major histocompatibility complex deficiency on circulating autoantibody levels in autoimmune-prone miceWilliam Stohl
Division of Rheumatology, University of Southern California Keck School of Medicine, Los Angeles, CA 90333, USA
Arthritis Rheum 50:2227-39. 2004..To assess the effects of altered class II major histocompatibility complex (MHCII) expression on circulating autoantibody levels in C57BL/6 (B6) mice congenic for the Sle1 (B6.Sle1 mice) or Nba2 (B6.Nba2 mice) regions...
- Gamma delta T cell homeostasis is controlled by IL-7 and IL-15 together with subset-specific factorsRoberto Baccala
Department of Immunology, The Scripps Research Institute, La Jolla, CA 92037, USA
J Immunol 174:4606-12. 2005..Thus, gamma delta T cell homeostasis is maintained by trophic cytokines commonly used by other types of lymphoid cells, as well as by additional, as yet unidentified, gamma delta-specific factors...
- IL-12-independent LIGHT signaling enhances MHC class II disparate CD4+ T cell alloproliferation, IFN-gamma responses, and intestinal graft-versus-host diseaseGeri R Brown
Division of Digestive and Liver Diseases, Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, TX 75235 9151, USA
J Immunol 174:4688-95. 2005..4 x 10(6) (n = 6) vs 0.36 +/- 0.02 x 10(6) (n = 9); p = 0.03 and p = 0.007) compared with control adenovirus (0.86 +/- 0.42 x 10(6); n = 9). LIGHT is critical for optimal CD4+ T cell alloresponses in MHC class II-disparate MLC and GVHD...
- Host responses to intestinal microbial antigens in gluten-sensitive miceJane M Natividad
Farncombe Family Digestive Health Research Institute, McMaster University, Hamilton, Canada
PLoS ONE 4:e6472. 2009..The aim of this study was to investigate whether intestinal barrier dysfunction induced by indomethacin treatment affects the host response to intestinal microbiota in gluten-sensitized HLA-DQ8/HCD4 mice...
- Presenilins regulate alphabeta T cell development by modulating TCR signalingKaren Laky
Laboratory of Cellular and Molecular Immunology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
J Exp Med 204:2115-29. 2007....
- Accelerated atherosclerosis in ApoE deficient lupus mouse modelsZhongjie Ma
Divisions of Rheumatology, Department of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA
Clin Immunol 127:168-75. 2008..These observations define a connection between induction of lupus-like symptoms and development of severe atherosclerosis in ApoE deficient lupus mouse models...
- Characterization of the protective T-cell response generated in CD4-deficient mice by a live attenuated Mycobacterium tuberculosis vaccineSteven C Derrick
Center for Biologics Evaluation and Research, Food and Drug Administration, Bethesda, MD 20892, USA
Immunology 120:192-206. 2007....
- Establishment of the major compatibility complex-dependent development of CD4+ and CD8+ T cells by the Cbl family proteinsFang Huang
Department of Microbiology, Columbia University College of Physicians and Surgeons, 701 West 168th Street, New York, New York 10032, USA
Immunity 25:571-81. 2006..They likely do so by suppressing MHC-independent NF-kappaB activation, possibly through downmodulating pre-TCR signaling in DP thymocytes...
- TRAIL deficiency does not rescue impaired CD8+ T cell memory generated in the absence of CD4+ T cell helpJilian A Sacks
Department of Immunology and Howard Hughes Medical Institute, University of Washington, Seattle, WA 98195, USA
J Immunol 180:4570-6. 2008..Overall, our results suggest that CD4(+) T cell help for the CD8(+) T cell response is not contingent on the silencing of TRAIL expression and prevention of TRAIL-mediated apoptosis...
- Murine Vbeta3+ and Vbeta7+ T cell subsets are specific targets for the HERV-K18 Env superantigenAlbert K Tai
Department of Pathology, Tufts University School of Medicine, Boston, MA 02111, USA
J Immunol 177:3178-84. 2006..The definition of the murine Vbeta specificity and the establishment of a transgenic model will permit the investigation of the role of this superantigen in the life cycle of EBV and its implicated diseases...
- CD40 engagement on dendritic cells, but not on B or T cells, is required for long-term control of murine gammaherpesvirus 68Francesca Giannoni
Viral Immunology, Torrey Pines Institute for Molecular Studies, 3550 General Atomics Court, San Diego, CA 92121, USA
J Virol 82:11016-22. 2008..Taken together, our data suggest that CD40 engagement on DC, but not on T or B cells, is essential for effective long-term control of MHV-68...
- Constitutive activation of STAT5 supersedes the requirement for cytokine and TCR engagement of CD4+ T cells in steady-state homeostasisDevon K Taylor
Department of Medicine, University of Pennsylvania, 415 Curie Boulevard, Philadelphia, PA 19104, USA
J Immunol 177:2216-23. 2006..This suggests that the need for TCR stimulation to induce common gamma-chain cytokine receptor expression, and thus STAT5 activation, is a key factor in maintaining normal CD4+ T cell homeostasis...
- ThPOK acts late in specification of the helper T cell lineage and suppresses Runx-mediated commitment to the cytotoxic T cell lineageTakeshi Egawa
Molecular Pathogenesis Program, The Helen and Martin Kimmel Center for Biology and Medicine at the Skirball Institute of Biomolecular Medicine, New York University School of Medicine, New York, NY 10016, USA
Nat Immunol 9:1131-9. 2008..Our results suggest that MHC class II-selected thymocytes are directed toward the CD4(+) lineage independently of ThPOK but require ThPOK to prevent Runx-dependent differentiation toward the CD8(+) lineage...
- The generation of protective memory-like CD8+ T cells during homeostatic proliferation requires CD4+ T cellsSara E Hamilton
Department of Laboratory Medicine and Pathology, University of Minnesota Medical Center, Center for Immunology, Minneapolis, Minnesota 55454, USA
Nat Immunol 7:475-81. 2006..Thus, like conventional CD8(+) memory T cells, the protective function of HP-memory CD8(+) T cells shows dependence on CD4(+) T cell help...
- Cascading suppression of transcriptional silencers by ThPOK seals helper T cell fateSawako Muroi
Laboratory for Transcriptional Regulation, RIKEN Research Center for Allergy and Immunology, Yokohama, Japan
Nat Immunol 9:1113-21. 2008..Our results show how an initial lineage-specification signal can be amplified and stabilized during the lineage-commitment process...
- Themis, a T cell-specific protein important for late thymocyte developmentRenaud Lesourne
Laboratory of Mammalian Genes and Development, Eunice Kennedy Shriver National Institute of Child Health and Human Development, Bethesda, Maryland, USA
Nat Immunol 10:840-7. 2009..Our results identify Themis as a critical component of the T cell developmental program and suggest that Themis functions to sustain and/or integrate signals required for proper lineage commitment and maturation...
- CCR6 regulates CD4+ T-cell-mediated acute graft-versus-host disease responsesRosa Varona
Departamento de Inmunologia y Oncologia, Centro Nacional de Biotecnologia CSIC, Universidad Autonoma de Madrid, Cantoblanco, Madrid, Spain
Blood 106:18-26. 2005..We suggest a role for CCR6 in recruiting alloreactive CD4+ T cells to target tissues and identify CCR6 as a potential therapeutic target for GvHD...
- CD8+ but not CD4+ T cells require cognate interactions with target tissues to mediate GVHD across only minor H antigens, whereas both CD4+ and CD8+ T cells require direct leukemic contact to mediate GVLCatherine Matte-Martone
Section of Medical Oncology, Cancer Center, Yale University School of Medicine, New Haven, CT 06520 8032, USA
Blood 111:3884-92. 2008..Thus, CD4 cells use distinct effector mechanisms in GVHD and GVL: direct cytolytic action is required for GVL but not for GVHD. If these noncytolytic pathways can be inhibited, then GVHD might be ameliorated while preserving GVL...
- The CD8 population in CD4-deficient mice is heavily contaminated with MHC class II-restricted T cellsAaron J Tyznik
Howard Hughes Medical Institute, University of Washington, Seattle 98195, USA
J Exp Med 199:559-65. 2004..These results have implications for understanding CD4 versus CD8 lineage commitment in the thymus, and for the practical use of CD4-/- mice as models of helper deficiency...
- Salmonella typhimurium aroA- infection in gene-targeted immunodeficient mice: major role of CD4+ TCR-alpha beta cells and IFN-gamma in bacterial clearance independent of intracellular locationJ Hess
Department of Immunology, University of Ulm, Germany
J Immunol 156:3321-6. 1996..typhimurium SL7207 Hlys and control strains did not differ in beta 2m-/- mutants. This finding argues against direct correlation of cytosolic location of S. typhimurium SL7207 Hlys with CD8+ T cell dependency of protection...
- CD40 signaling replaces CD4+ lymphocytes and its blocking prevents chronic rejection of heart transplantsM P Fischbein
Department of Microbiology, Immunology, and Molecular Genetics, Division of Cardiothoracic Surgery, University of California Los Angeles School of Medicine, Los Angeles, CA 90095, USA
J Immunol 165:7316-22. 2000..Importantly, this study provides evidence that CD40 ligand-targeted therapies may prevent chronic rejection only in strain combinations where CD4(+) lymphocyte help is absolutely required...
- Rejection of allogeneic and syngeneic but not MHC class I-deficient tumor grafts by MHC class I-deficient miceS Freland
Microbiology and Tumor Biology Center, Karolinska Institute, Stockholm, Sweden
J Immunol 160:572-9. 1998..The present results are discussed in relation to the role of MHC class I molecules in selecting functional CD8+ T and NK cell repertoires, and the development of cell-mediated immunity...
- Diversity of T cell repertoire shaped by a single peptide ligand is critically affected by its amino acid residue at a T cell receptor contactY Fukui
Department of Genetics, CREST Core Research for Evolutional Science and Technology, Medical Institute of Bioregulation, Kyushu University, Fukuoka 812 8582, Japan
Proc Natl Acad Sci U S A 97:13760-5. 2000..Our findings thus suggest that positive selection is both specific and degenerate, depending on the amino acid residues at TCR contacts of the selecting self-peptides...
- Enhancement of MHC class I-stimulated alloresponses by TNF/TNF receptor (TNFR)1 interactions and of MHC class II-stimulated alloresponses by TNF/TNFR2 interactionsG R Brown
Department of Internal Medicine, University of Texas Southwestern Medical Center at Dallas, 75390 9151, USA
Eur J Immunol 30:2900-7. 2000..These results indicate that TNF/TNFR2 interactions promote MHC class II-stimulated alloresponses, while TNF/TNFR1 interactions promote MHC class I-stimulated alloresponses...
- Altered major histocompatibility complex class II peptide loading in H2-O-deficient miceM Perraudeau
Transplantation Biology Group, MRC Clinical Sciences Centre, Imperial College School of Medicine, Hammersmith Hospital, London, GB
Eur J Immunol 30:2871-80. 2000....
- Murine I-A beta chain polymorphism: nucleotide sequences of three allelic I-A beta genesE Choi
Science 221:283-6. 1983..The differences were found to be a series of short alterations clustered in the amino terminal half of the polypeptide...
- Allospecific cytotoxic T cells generated from beta 2m-/- mice in primary MLC: analysis of activation requirements, specificity, and phenotypeE Lamouse-Smith
Department of Molecular Genetics and Biochemistry, University of Pittsburgh School of Medicine, Pennsylvania 15213, USA
Cell Immunol 179:107-15. 1997..This phenotypic variability of beta 2m-/- CTL generated in primary MLC reveals the diversity of CTL precursors that develop in vivo in the absence of MHC Class I...
- Suppression of allograft responses induced by interleukin-6, which selectively modulates interferon-gamma but not interleukin-2 productionM Tomura
Basic Research Laboratories, Toray Industries Inc, Kanagawa, Japan
Transplantation 64:757-63. 1997..Interferon (IFN)-gamma produced by activated T cells represents an important effector cytokine in mediating an inflammatory response...
- Hypogammaglobulinaemia occurs in Fas-deficient MRL-lpr mice following deletion of MHC class II moleculesC C Anderson
Department of Microbiology and Immunology, University of Western Ontario, London, Canada
Clin Exp Immunol 109:473-9. 1997..These results define a general abnormal regulation of B cells in MRL-lpr mice through a process requiring MHC class II, and suggest that Fas deficiency may allow expansion of totally T-dependent B cells...
- How subtle differences in MHC class II affect the severity of experimental myasthenia gravisB Yang
Department of Neurology, Johns Hopkins School of Medicine, Baltimore, Maryland 21287 7519, USA
Clin Immunol Immunopathol 86:45-58. 1998....
- Residual MHC class II expression on mature dendritic cells and activated B cells in RFX5-deficient miceB E Clausen
Institute for Genetics, University of Cologne, Germany
Immunity 8:143-55. 1998..This differential requirement for CIITA and RFX5 in subsets of antigen-presenting cells may be specific for the mouse; it may, however, also exist in humans without having been noticed so far...
- Differential activities of the RET tyrosine kinase receptor isoforms during mammalian embryogenesisE de Graaff
Division of Developmental Neurobiology, Medical Research Council MRC National Institute for Medical Research, The Ridgeway, Mill Hill, London NW7 1AA, UK
Genes Dev 15:2433-44. 2001..Our findings show that RET9 and RET51 have different signaling properties in vivo and define specific temporal and spatial requirements of c-Ret function during renal development and histogenesis of the enteric nervous system...
- A critical, invariant chain-independent role for H2-M in antigen presentationK Swier
Department of Medicine, Gwen Knapp Center for Lupus and Immunology Research, University of Chicago, Illinois 60637, USA
J Immunol 160:540-4. 1998..In contrast to Ii-deficient (Ii0) mice, Ii0H2-M0 mice were as susceptible to L. major as H2-M0 mice. Thus, H2-M has an essential, Ii-independent function during presentation of microbial pathogens...
- The developmentally regulated expression of Twisted gastrulation reveals a role for bone morphogenetic proteins in the control of T cell developmentDaniel Graf
Lymphocyte Development Group, Medical Research Council Clinical Sciences Centre, Imperial College of Medicine, London W12 0NN, United Kingdom
J Exp Med 196:163-71. 2002..These data suggest that the developmentally regulated expression of Tsg may allow thymocytes to temporarily withdraw from inhibitory BMP signals...
- The vital role of BAFF in the development of SLEWilliam Stohl; Fiscal Year: 2010..abstract_text> ..
- Role of B cells in pathogenesis of Collagen-induced Arthritis in Humanized MiceVeena Taneja; Fiscal Year: 2010..The information gained using this unique model may be instructive in developing preventive immunointervention for ongoing arthritis especially in women. ..
- Role of B cells in pathogenesis of Collagen-induced Arthritis in Humanized MiceVeena Taneja; Fiscal Year: 2010..The information gained using this unique model may be instructive in developing preventive immunointervention for ongoing arthritis especially in women. ..
- The vital role of BAFF in the development of SLEWilliam Stohl; Fiscal Year: 2007....
- Multimodality Therapy for Metastatic Breast CancerJonathan Serody; Fiscal Year: 2006..The long-term goals of this work are to evaluate safe and effective therapies that induce a complete remission for the treatment of women with metastatic breast cancer. ..
- Treg Migration in GVHDJonathan Serody; Fiscal Year: 2007..The overall goals of this work are to provide a better understanding of the mechanism of activity of Treg cells prior to a clinical trial evaluating their effects in blocking GVHD. ..
- Pneumococcal immunization through a novel mechanismRichard Malley; Fiscal Year: 2007....
- Pneumolysin, Innate and Acquired Immunity to PneumococciRichard Malley; Fiscal Year: 2005..The establishment of a link between the innate and the acquired arm of the immune response to pneumococcus may provide a better understanding of the mechanisms by which immunity to pneumococcus is acquired. ..
- Treg Migration in GVHDJonathan Serody; Fiscal Year: 2009..The overall goals of this work are to provide a better understanding of the mechanism of activity of Treg cells prior to a clinical trial evaluating their effects in blocking GVHD. ..
- Mechanisms of Immunity to Pneumococcal ColonizationRichard Malley; Fiscal Year: 2007..The results of our experiments will define a previously-unrecognized mechanism of protection against extracellular encapsulated bacteria and help in the development of novel vaccines against pneumococcus. ..
- Mechanisms of Immunity to Pneumococcal ColonizationRichard Malley; Fiscal Year: 2010..The results of our experiments will define a previously-unrecognized mechanism of protection against extracellular encapsulated bacteria and help in the development of novel vaccines against pneumococcus. ..
- Mechanisms Involved in T cell trafficking in GVHDJonathan Serody; Fiscal Year: 2007..We will evaluate if small peptides that could be used clinically are effective in blocking the occurrence of GVHD as a prelude to their use in phase I clinical trials. ..
- Pneumococcal immunization through a novel mechanismRichard Malley; Fiscal Year: 2010..abstract_text> ..
- Mechanisms of Immunity to Pneumococcal ColonizationRichard Malley; Fiscal Year: 2009..The results of our experiments will define a previously-unrecognized mechanism of protection against extracellular encapsulated bacteria and help in the development of novel vaccines against pneumococcus. ..
- Analysis of CD81-PGRL complex on T cellsSTEPHEN CHAPES; Fiscal Year: 2007..The coordinated effect of CD81, PGRL and EP3 on T cell integrin activity measured by adhesion to or motility on ICAMs. ..
- Immune Response to Small Nuclear Ribonucleoprotein AutoantigensEric L Greidinger; Fiscal Year: 2010..Our research goal is to develop new and effective treatments of these disorders. ..
- Vector and Host Contributions to the Regulation of E. chaffeensis Gene ExpressionROMAN GANTA; Fiscal Year: 2009..chaffeensis gene regulation and how the rickettsiale in macrophages and tick cells respond to the loss of expression from a differentially expressed protein. ..
- MECHANISMS OF SYNERGISTIC REGULATION OF STEM/PROGENITORSHal E Broxmeyer; Fiscal Year: 2010....
- Vector and Host Contributions to the Regulation of E. chaffeensis Gene ExpressionRoman R Ganta; Fiscal Year: 2011..chaffeensis gene regulation and how the rickettsiale in macrophages and tick cells respond to the loss of expression from a differentially expressed protein. ..
- Interaction between influenza virus and H. influenzaeSally Sarawar; Fiscal Year: 2007..This could be particularly important during an influenza pandemic and may be more broadly applicable to other respiratory viruses. ..
- MECHANISMS OF SYNERGISTIC REGULATION OF STEM/PROGENITORSHal Broxmeyer; Fiscal Year: 2003..abstract_text> ..
- APOPTOSIS-MODIFIED SELF ANTIGEN IN RHEUMATIC DISEASEEric Greidinger; Fiscal Year: 2002..In the future, this work may lead to the development of specific immunotherapy strategies for the treatment of Ul-70kDa-associated rheumatic disorders. ..
- Functional and Anatomical Characterization of the Hematopoietic Stem Cell NicheDeepta Bhattacharya; Fiscal Year: 2007..The goal of this proposal is to better characterize the properties of these niches and to determine how best to utilize these niches for bone marrow transplantation. ..
- Anti-Tumor Autoimmunity by lymphopenia T cell ExpansionRoberto Baccala; Fiscal Year: 2007..The results will define the role of homeostatic T cell proliferation in tumor autoimmunity, and provide new approaches to the treatment of cancer. ..
- CHEMOKINES/CYTOKINES AND RECEPTORS IN STEM CELL HOMINGHal Broxmeyer; Fiscal Year: 2005..These studies should clarity the relevance of SDF-1 and CXCR4 for homing/engraftment and mobilization of primary stem/progenitor cells. ..
- Viral Decoy ReceptorsDaved Fremont; Fiscal Year: 2006..abstract_text> ..
- Gene expression in non-functional CD8 T cellsSally Sarawar; Fiscal Year: 2005..The data are likely to lead to a new understanding of how CD8 T cells function in the control of persistent viral infections and mechanisms of CD8 T cell activation. ..