Genomes and Genes
Gene Symbol: H2-Ab1
Description: histocompatibility 2, class II antigen A, beta 1
Alias: AI845868, Abeta, H-2Ab, H2-Ab, I-Abeta, IAb, Ia-2, Ia2, Rmcs1, H-2 class II histocompatibility antigen, A beta chain, MHC class II H2-IA-beta-psi, MHC class II antigen A beta, major histocompatibility complex class II beta chain, response to metastatic cancers 1
Publications146 found, 100 shown here
- Dendritic cells regulate exposure of MHC class II at their plasma membrane by oligoubiquitinationGuillaume van Niel
Faculty of Veterinary Medicine, Department of Biochemistry and Cell Biology, Utrecht University, P O Box 80 176, NL 3508 TD, Utrecht, The Netherlands
Immunity 25:885-94. 2006..Together, these data provide a molecular basis for the regulation of MHC class II-mediated antigen presentation by DCs...
- Autonomous role of medullary thymic epithelial cells in central CD4(+) T cell toleranceMaria Hinterberger
Institute for Immunology, Ludwig Maximilians Universitat, Munich, Germany
Nat Immunol 11:512-9. 2010..Our data document an autonomous contribution of mTECs to both dominant and recessive mechanisms of CD4(+) T cell tolerance and support an avidity model of T(reg) cell development versus deletion...
- Mice lacking MHC class II moleculesD Cosgrove
Laboratoire de Genetique Moleculaire des Eucaryotes du CNRS, Unité 184 de Biologie Moléculaire de Génie Génétique de l INSERM, Faculte de Medecine, Strasbourg, France
Cell 66:1051-66. 1991..In short, the class II-negative mice have confirmed some old ideas about lymphocyte differentiation, but have provided some surprises...
- Characterization of the early stages of thymic NKT cell developmentKamel Benlagha
Committee on Immunology, The University of Chicago, Chicago, IL 60637, USA
J Exp Med 202:485-92. 2005..1neg CD4 cells. These findings identify the HSAhigh CD4+ stage as a potential branchpoint between NKT and conventional T lineages and between the CD4 and DN NKT sublineages...
- Organ-specific regulation of the CD8 T cell response to Listeria monocytogenes infectionC Pope
Division of Rheumatic Diseases, University of Connecticut Health Center, Farmington, CT 06030, USA
J Immunol 166:3402-9. 2001..Overall, the results point to novel pathways of tissue-specific regulation of primary and memory antimicrobial CD8 T cell responses...
- TIM-3: a novel regulatory molecule of alloimmune activationOlaf Boenisch
Transplantation Research Center, Brigham and Women s Hospital and Children s Hospital Boston, Boston, MA 02115, USA
J Immunol 185:5806-19. 2010..In summary, TIM-3 is a key regulatory molecule of alloimmunity through its ability to broadly modulate CD4(+) T cell differentiation, thus recalibrating the effector and regulatory arms of the alloimmune response...
- Expansion of peripheral naturally occurring T regulatory cells by Fms-like tyrosine kinase 3 ligand treatmentLee Kim Swee
Departement Biomedizin Basel, University of Basel, Switzerland
Blood 113:6277-87. 2009..It also reinforces the relevance of FLT3L treatment in GVHD by its ability to increase both the number of tolerizing DCs and NTregs...
- Signaling by intrathymic cytokines, not T cell antigen receptors, specifies CD8 lineage choice and promotes the differentiation of cytotoxic-lineage T cellsJung Hyun Park
Experimental Immunology Branch, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA
Nat Immunol 11:257-64. 2010....
- Major histocompatibility complex class I molecules are required for the development of insulitis in non-obese diabetic miceJ Katz
Laboratoire de Genetique Moleculaire des Eucaryotes du CNRS, Strasbourg, France
Eur J Immunol 23:3358-60. 1993..We question this interpretation because NOD mice lacking MHC class I molecules, hence CD8+ T cells, do not display even insulitis when expected...
- NK1.1+ T cells in the liver arise in the thymus and are selected by interactions with class I molecules on CD4+CD8+ cellsM C Coles
Department of Molecular and Cell Biology and Cancer Research Laboratory, University of California, Berkeley, CA 94720, USA
J Immunol 164:2412-8. 2000..1+ T cells or are induced to proliferate after having left the thymus. The results indicate that NK1.1+ T cells, like conventional T cells, arise in the thymus where they are selected by interactions with restricting molecules...
- CD8+ cells enhance resistance to pulmonary serotype 3 Streptococcus pneumoniae infection in miceSarah E Weber
Department of Microbiology and Immunology, Albert Einstein College of Medicine, Bronx, NY 10461, USA
J Immunol 186:432-42. 2011....
- Selected Toll-like receptor ligands and viruses promote helper-independent cytotoxic T cell priming by upregulating CD40L on dendritic cellsSusan Johnson
Autoimmunity and Transplantation Division, Walter and Eliza Hall Institute of Medical Research, Parkville, Australiaia
Immunity 30:218-27. 2009..Thus, CD40L upregulation on DCs promoted optimal priming of CD8(+) T cells without CD4(+) T cells, providing a mechanism by which pathogens may elicit helper-independent CTL immunity...
- The NOD mouse: recessive diabetogenic gene in the major histocompatibility complexM Hattori
Science 231:733-5. 1986..In crosses of NOD mice with control C3H mice, the development of diabetes was dependent on homozygosity for the NOD mouse's unique major histocompatibility region...
- Functionality of major histocompatibility complex class II molecules in mice doubly deficient for invariant chain and H-2M complexesS Tourne
Institut de Genetique et de Biologie Moleculaire et Cellulaire, Centre National de la Recherche Scientifique, Institut National de la Sante et de la Recherche Medicale, University Louis Pasteur 1, Strasbourg, France
Proc Natl Acad Sci U S A 94:9255-60. 1997....
- Invariant chain-independent function of H-2M in the formation of endogenous peptide-major histocompatibility complex class II complexes in vivoS Kovats
Department of Immunology, University of Washington School of Medicine, Seattle 98195, USA
J Exp Med 187:245-51. 1998..These findings are consistent with the idea that H-2M functions as a chaperone in the peptide loading of class II molecules in vivo...
- On the role of MHC class II molecules in the survival and lymphopenia-induced proliferation of peripheral CD4+ T cellsBruno Martin
Institut National de la Santé et de la Recherche Médicale U561, Hopital Saint Vincent de Paul, 75014 Paris, France
Proc Natl Acad Sci U S A 100:6021-6. 2003..Nevertheless, interactions with classical MHC class II molecules are required for CD4(+) T cells to survive in CD8(+) T-cell-containing mice...
- Compromised influenza virus-specific CD8(+)-T-cell memory in CD4(+)-T-cell-deficient miceGabrielle T Belz
Department of Immunology, St Jude Children s Research Hospital, Memphis, Tennessee 38105, USA
J Virol 76:12388-93. 2002..These findings are consistent with mathematical models that predict virus-host dynamics in this, and other, models of infection...
- Timing and casting for actors of thymic negative selectionN Dautigny
Institut National de la Sante et de la Recherche Medicale, Unit 345, Institut Necker, Paris, France
J Immunol 162:1294-302. 1999..Finally, we show involvement in opposing directions for p59fyn and SHP-1 molecules in signaling for thymic negative selection...
- B6.C-H-2bm12. A new H-2 mutation in the I region in the mouseI F McKenzie
J Exp Med 150:1323-38. 1979..Serological analysis with a battery of H-2b, Iab, and other Ia sera, both by cytotoxicity, rosetting, and also by absorption analysis, indicated no alteration in H-..
- Mice lacking major histocompatibility complex class I and class II moleculesM J Grusby
Department of Cancer Biology, Harvard School of Public Health, Boston, MA 02115
Proc Natl Acad Sci U S A 90:3913-7. 1993..Taken together, these results emphasize the plasticity of the immune system and suggest that MHC-deficient mice may be useful for examining compensatory mechanisms in severely immunocompromised animals...
- The role of the Runx transcription factors in thymocyte differentiation and in homeostasis of naive T cellsTakeshi Egawa
Molecular Pathogenesis Program, Skirball Institute of Biomolecular Medicine, New York University School of Medicine, New York, NY 10016, USA
J Exp Med 204:1945-57. 2007..These results indicate that Runx proteins have important roles at multiple stages of T cell development and in the homeostasis of mature T cells...
- Mice lacking all conventional MHC class II genesL Madsen
Department of Clinical Immunology, Rigshospitalet, 2200 Copenhagen, Denmark
Proc Natl Acad Sci U S A 96:10338-43. 1999..These mice feature immune system perturbations like those of Aalpha and Abeta knockout animals, notably a dearth of CD4(+) lymphocytes in the thymus and spleen...
- Modulation of coreceptor transcription during positive selection dictates lineage fate independently of TCR/coreceptor specificitySophia D Sarafova
Experimental Immunology Branch, National Cancer Institute, Bethesda, Maryland 20892, USA
Immunity 23:75-87. 2005..This study demonstrates that termination of coreceptor transcription during positive selection promotes CD8-lineage fate, regardless of TCR specificity or coreceptor protein identity...
- In the absence of a CD40 signal, B cells are tolerogenicJ E Buhlmann
Department of Microbiology, Dartmouth Medical School, Lebanon, New Hampshire 03756, USA
Immunity 2:645-53. 1995..These studies provide insights into the tolerogenic capacity of resting B cells and outlines a practical approach to exploit this function...
- Gene conversion between murine class II major histocompatibility complex loci. Functional and molecular evidence from the bm 12 mutantL Mengle-Gaw
J Exp Med 160:1184-94. 1984....
- CD4-CD8 lineage commitment is regulated by a silencer element at the ThPOK transcription-factor locusXi He
Fox Chase Cancer Center, 7701 Burholme Ave, Philadelphia, PA 19111, USA
Immunity 28:346-58. 2008..We propose a silencer-dependent model of lineage choice, whereby inactivation of the DRE silencer by a strong TCR signal leads to CD4 commitment, whereas continued silencer activity leads to CD8 commitment...
- Visualization of CD4/CD8 T cell commitmentS Chan
Institut de Genetique et de Biologie Moleculaire et Cellulaire CNRS INSERM ULP, Strasbourg, 67404 Illkirch Cedex, France
J Exp Med 188:2321-33. 1998..Finally, we found no evidence of a CD4 default pathway...
- Asymmetric signaling requirements for thymocyte commitment to the CD4+ versus CD8+ T cell lineages: a new perspective on thymic commitment and selectionH Suzuki
Experimental Immunology Branch, National Cancer Institute, Bethesda, Maryland 20892, USA
Immunity 2:413-25. 1995..These results are incompatible with current concepts and require a new perspective on lineage commitment and positive selection, which we refer to as asymmetric commitment...
- Regulation of lineage commitment distinct from positive selectionR Keefe
Fox Chase Cancer Center, 7701 Burholme Avenue, Philadelphia, PA 19111, USA
Science 286:1149-53. 1999..However, neither TCR-mediated signaling nor positive selection is impaired. Thus, the HD mutation provides genetic evidence that lineage commitment may be mechanistically distinct from positive selection...
- CD4+ T cells are required for the maintenance, not programming, of memory CD8+ T cells after acute infectionJoseph C Sun
Department of Immunology and the Howard Hughes Medical Institute, University of Washington, Seattle, Washington 98195, USA
Nat Immunol 5:927-33. 2004..We conclude that in the context of an acute infection, CD4(+) T cells are required only during the maintenance phase of long-lived memory CD8(+) T cells...
- Role of CD4 T cell help and costimulation in CD8 T cell responses during Listeria monocytogenes infectionDevon J Shedlock
Department of Microbiology, School of Medicine, University of Pennsylvania, 3610 Hamilton Walk, Philadelphia, PA 19104 6076, USA
J Immunol 170:2053-63. 2003....
- HD mice: a novel mouse mutant with a specific defect in the generation of CD4(+) T cellsV P Dave
Fox Chase Cancer Center, 7701 Burholme Avenue, Philadelphia, PA 19111, USA
Proc Natl Acad Sci U S A 95:8187-92. 1998..This is the first genetic defect of its kind to be described in the mouse and may prove highly informative in understanding the molecular pathways underlying lineage commitment...
- Cascading suppression of transcriptional silencers by ThPOK seals helper T cell fateSawako Muroi
Laboratory for Transcriptional Regulation, RIKEN Research Center for Allergy and Immunology, Yokohama, Japan
Nat Immunol 9:1113-21. 2008..Our results show how an initial lineage-specification signal can be amplified and stabilized during the lineage-commitment process...
- Nonself-antigens are the cognate specificities of Foxp3+ regulatory T cellsRafal Pacholczyk
Center for Biotechnology and Genomic Medicine, Medical College of Georgia, Augusta, GA 30912, USA
Immunity 27:493-504. 2007..Our results show that high-affinity, autoreactive TCRs are rare on all CD4+ T cells and suggest that selecting self-peptide is different from the peptide that activates the same regulatory T cells in the periphery...
- Epistatic suppression of systemic lupus erythematosus: fine mapping of Sles1 to less than 1 mbSrividya Subramanian
Center for Immunology and Department of Pathology, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, TX 75390, USA
J Immunol 175:1062-72. 2005..Sle1 Sles1)F(1)s. These findings localize and characterize the suppressive properties of Sles1 and implicate 129 as a useful strain for aiding in the identification of this elusive epistatic modifier gene...
- Conditional ablation of MHC-II suggests an indirect role for MHC-II in regulatory CD4 T cell maintenanceMichiko Shimoda
Molecular Immunology Program and Immunotherapy Center, Medical College of Georgia, Augusta, GA 30912, USA
J Immunol 176:6503-11. 2006..Thus, our findings lend support to the proposal that Treg cell homeostasis depends on a delicate balance with a population of self-reactive IL-2-producing CD4+CD25+ cells which are themselves at least in part MHC-II-dependent...
- The mouse CD1d-restricted repertoire is dominated by a few autoreactive T cell receptor familiesS H Park
Department of Molecular Biology, Princeton University, Princeton, New Jersey 08544, USA
J Exp Med 193:893-904. 2001..Altogether, these findings imply that lipid recognition by CD1d-restricted T cells may have largely evolved as an innate rather than an adaptive arm of the mouse immune system...
- Epigenetic silencing of CD4 in T cells committed to the cytotoxic lineageY R Zou
Molecular Pathogenesis Program, Skirball Institute of Biomolecular Medicine, New York University School of Medicine, New York, New York 10016, USA
Nat Genet 29:332-6. 2001..The epigenetic inheritance of the silenced CD4 locus was not affected by the inhibition of DNA methylation or histone deacetylation, and may thus involve other mechanisms that ensure a stable state of gene expression...
- CD8alpha+ and CD11b+ dendritic cell-restricted MHC class II controls Th1 CD4+ T cell immunityMaria P Lemos
Department of Medicine, University of Pennsylvania, Philadelphia PA 19104, USA
J Immunol 171:5077-84. 2003..These findings indicate that DCs are not only key initiators of the primary response, but provide all of the necessary cognate interactions to control CD4(+) T cell fate during the primary immune response...
- A reassessment of the effect of activated Notch1 on CD4 and CD8 T cell developmentB J Fowlkes
Laboratory of Cellular and Molecular Immunology, National Institutes of Health, Bethesda, MD 20892, USA
J Immunol 169:1817-21. 2002..We suggest that the discrepancies in previous reports of Notch1IC transgenic mice are due to differences in the propensity of the two different transgenic lines to develop tumors...
- Characterization of HLA DR2 and DQ8 transgenic mouse with a new engineered mouse class II deletion, which lacks all endogenous class II genesS Cheng
Department of Immunology, Mayo Clinic, 200 First Street SW, Rochester, MN 55905, USA
J Autoimmun 21:195-9. 2003..However, these mice carry the functional mouse Eb gene from the Abeta(0/0) construct and could express Ebeta/DRalpha(Ealpha) molecules and shape the T cell repertoire in these mice...
- HLA-DQ determines the response to exogenous wheat proteins: a model of gluten sensitivity in transgenic knockout miceKay E Black
Department of Immunology, Division of Gastroenterology and Hepatology, Mayo Clinic and Foundation, 220 1st Street SW, Rochester, MN 55905, USA
J Immunol 169:5595-600. 2002..These data suggest that this HLA class II transgenic murine model of gluten sensitivity may provide insight into the initiation of the MHC class II-restricted gluten sensitivity in celiac disease...
- A conditional null allele of the major histocompatibility IA-beta chain geneKahoko Hashimoto
Institute of Molecular Medicine and Genetics and Department of Medicine, Medical College of Georgia, Augusta, Georgia 30912, USA
Genesis 32:152-3. 2002
- HLA-DR4-IE chimeric class II transgenic, murine class II-deficient mice are susceptible to experimental allergic encephalomyelitisK Ito
Department of Inflammation and Autoimmune Diseases, Hoffmann La Roche Inc, Nutley, New Jersey 07110, USA
J Exp Med 183:2635-44. 1996..Non-Tg mice immunized with either PLP175-192 or MBP87-106 did not develop EAE. These results demonstrated that a human MHC class II binding site alone can confer susceptibility to an experimentally induced murine autoimmune disease...
- Antigen presentation and T cell development in H2-M-deficient miceW P Fung-Leung
R W Johnson Pharmaceutical Research Institute, San Diego, CA 92121, USA
Science 271:1278-81. 1996..Their CD4+ cells were unresponsive to self H2-M-deficient antigen-presenting cells (APCs) but were hyperreactive to wild-type APCs. H2-M-deficient APCs failed to elicit proliferative responses from wild-type T cells...
- The repertoire of T cells shaped by a single MHC/peptide ligandL Ignatowicz
Department of Medicine, National Jewish Center for Immunology and Respiratory Medicine, University of Colorado Health Sciences Center, Denver, 80206, USA
Cell 84:521-9. 1996..T cells that mature in thymuses expressing a single MHC/peptide ligand react frequently with foreign MHC, suggesting that the repertoire of alpha beta receptors may be more biased toward reaction with MHC than was previously thought...
- H2-M mutant mice are defective in the peptide loading of class II molecules, antigen presentation, and T cell repertoire selectionW D Martin
Howard Hughes Medical Institute, Department of Microbiology and Immunology, Vanderbilt University School of Medicine, Nashville, Tennessee 37232, USA
Cell 84:543-50. 1996..Overall, this phenotype establishes an important role for H2-M in regulating MHC class II function in vivo and supports the notion that self-peptides contribute to the specificity of T cell positive selection...
- Mice lacking the MHC class II-associated invariant chainS Viville
Laboratorie de Génétique Moléculaire des Eucaryotes du CNRS, Strasbourg, France
Cell 72:635-48. 1993..Consequently, mutant cells present protein antigens very poorly and mutant mice are deficient in producing and at negatively selecting CD4+ T cells...
- The cytoplasmic domain of CD4 promotes the development of CD4 lineage T cellsA Itano
Department of Molecular and Cell Biology, University of California, Berkeley, 94720, USA
J Exp Med 183:731-41. 1996..We discuss these results in terms of current models for CD4 and CD8 lineage commitment...
- Depletion of CD4+ T cells in major histocompatibility complex class II-deficient miceM J Grusby
Department of Cancer Biology, Harvard School of Public Health, Boston, MA
Science 253:1417-20. 1991..These results provide genetic evidence that class II molecules are required for the maturation and function of mature CD4+ T cells...
- Mice lacking H2-M complexes, enigmatic elements of the MHC class II peptide-loading pathwayT Miyazaki
Institut de Genetique et de Biologie Moleculaire et Cellulaire, Universite Louis Pasteur, France
Cell 84:531-41. 1996..Peripheral T cells reacted strongly to splenocytes from syngeneic wild-type mice, no doubt reflecting the unique peptide complement carried by class II molecules in mutant animals...
- IL-2 receptor beta-dependent STAT5 activation is required for the development of Foxp3+ regulatory T cellsMatthew A Burchill
Department of Laboratory Medicine and Pathology, University of Minnesota, Minneapolis, MN 55455, USA
J Immunol 178:280-90. 2007..Finally, STAT5 binds to the promoter of the foxp3 gene suggesting that IL-2Rbeta-dependent STAT5 activation promotes Treg differentiation by regulating expression of foxp3...
- Repression of the transcription factor Th-POK by Runx complexes in cytotoxic T cell developmentRuka Setoguchi
Laboratory for Transcriptional Regulation, RIKEN Research Center for Allergy and Immunology, 1 7 22 Suehiro cho, Tsurumi ku, Yokohama 230 0045, Japan
Science 319:822-5. 2008..Identification of the transcription factors network in CD4 and CD8 lineage choice provides insight into how distinct T cell subsets are developed for regulating the adaptive immune system...
- MHC class II expression restricted to CD8alpha+ and CD11b+ dendritic cells is sufficient for control of Leishmania majorMaria P Lemos
Department of Medicine, University of Pennsylvania, Philadelphia 19104, USA
J Exp Med 199:725-30. 2004..major infection using a mouse model in which MHC II, I-Abeta(b), expression is restricted to CD11b+ and CD8alpha+ dendritic cells (DCs)...
- ThPOK acts late in specification of the helper T cell lineage and suppresses Runx-mediated commitment to the cytotoxic T cell lineageTakeshi Egawa
Molecular Pathogenesis Program, The Helen and Martin Kimmel Center for Biology and Medicine at the Skirball Institute of Biomolecular Medicine, New York University School of Medicine, New York, NY 10016, USA
Nat Immunol 9:1131-9. 2008..Our results suggest that MHC class II-selected thymocytes are directed toward the CD4(+) lineage independently of ThPOK but require ThPOK to prevent Runx-dependent differentiation toward the CD8(+) lineage...
- Dual functions of Runx proteins for reactivating CD8 and silencing CD4 at the commitment process into CD8 thymocytesTakehito Sato
Department of Immunology, Tokai University School of Medicine, Boseidai, Isehara, Kanagawa 259 1193, Japan
Immunity 22:317-28. 2005....
- The first external domain of the nonobese diabetic mouse class II I-A beta chain is uniqueH Acha-Orbea
Proc Natl Acad Sci U S A 84:2435-9. 1987..We suggest that the unique structure of the first external I-A beta chain domain is a major determinant in the disease susceptibility that maps to the major histocompatibility complex of the nonobese diabetic mouse...
- Major DQ8-restricted T-cell epitopes for human GAD65 mapped using human CD4, DQA1*0301, DQB1*0302 transgenic IA(null) NOD miceJ Liu
Department of Medical Microbiology and Immunology, University of Alberta, Edmonton, Canada
Diabetes 48:469-77. 1999....
- Class II major histocompatibility complex-deficient mice initially control an infection with Leishmania major but succumb to the diseaseH R Chakkalath
Department of Tropical Public Health, Harvard School of Public Health, Boston, Massachusetts, USA
J Infect Dis 171:1302-8. 1995..major and that in the absence of these cells and molecules, such mice can transiently control infection with L. major but are unable to resolve such infections...
- HLA-DQB1 polymorphism determines incidence, onset, and severity of collagen-induced arthritis in transgenic mice. Implications in human rheumatoid arthritisD S Bradley
Department of Immunology, Mayo Clinic and Medical School, Rochester, Minnesota 55905, USA
J Clin Invest 100:2227-34. 1997..These studies support a role for HLA-DQ polymorphism in human RA...
- Low activation threshold as a mechanism for ligand-independent signaling in pre-T cellsMariëlle C Haks
Division of Basic Sciences, Immunobiology Working Group, Fox Chase Cancer Center, Philadelphia, PA 19111, USA
J Immunol 170:2853-61. 2003..Taken together these data suggest that cell-autonomous, ligand-independent signaling is primarily a property of the thymocytes in which pre-TCR signaling occurs...
- In vivo treatment of class II MHC-deficient mice with anti-TCR antibody restores the generation of circulating CD4 T cells and optimal architecture of thymic medullaMariam Nasreen
Division of Experimental Immunology, Institute for Genome Research, University of Tokushima, Tokushima, Japan
J Immunol 171:3394-400. 2003....
- Antiviral immune responses of mice lacking MHC class II or its associated invariant chainM Battegay
Institute of Experimental Immunology, Department of Pathology, University of Zurich, Switzerland
Cell Immunol 167:115-21. 1996..This suggests that local protein concentrations reached during viral infection in the host are high enough to override the Ii deficiency of antigen-presenting cells in vivo...
- Another view of the selective model of thymocyte selectionS H Chan
Laboratoire de Genetique Moleculaire, Eucaryotes du Centre National de la Recherche Scientifique, Faculte de Medecine, Strasbourg, France
Cell 73:225-36. 1993....
- Complete characterization of the expressed immune response genes in Biozzi AB/H mice: structural and functional identity between AB/H and NOD A region moleculesG Y Liu
Cambridge University Department of Pathology, UK
Immunogenetics 37:296-300. 1993
- A role for CD40 expression on CD8+ T cells in the generation of CD8+ T cell memoryChristine Bourgeois
INSERM U345, Institut Necker, 156 rue de Vaugirard, F 75730 Paris Cedex 15, France
Science 297:2060-3. 2002..These results suggest that, like B cells, CD8+ T cells receive CD4 help directly through CD40 and that this interaction is fundamental for CD8+ T cell memory generation...
- Variable hematopoietic graft rejection and graft-versus-host disease in MHC-matched strains of miceThai M Cao
Department of Medicine, Stanford University School of Medicine, Stanford, CA 94305, USA
Proc Natl Acad Sci U S A 100:11571-6. 2003..Our results likely extend to all serologically MHC-matched mouse strains used in modern research and highlight the profound and variable influence that non-MHC genetic determinants can have in dictating outcome after HCT...
- Recipient MHC class II expression is required to achieve long-term survival of murine cardiac allografts after costimulatory blockadeA Yamada
Transplantation Unit, Surgical Services, Massachusetts General Hospital, Boston, MA 02114, USA
J Immunol 167:5522-6. 2001..These results suggest that an active CD4(+) response through the indirect pathway is necessary for costimulatory blockade to be effective in prolonging allograft survival...
- Requirements for allergen-induced airway inflammation and hyperreactivity in CD4-deficient and CD4-sufficient HLA-DQ transgenic miceS P Chapoval
Department of Immunology, Mayo Clinic, Rochester, MN 55905, USA
J Allergy Clin Immunol 108:764-71. 2001..Airway inflammation is central to the pathogenesis of allergic asthma, and molecules that mediate this process obviously represent targets for therapy...
- Critical role of inducible costimulator signaling in the development of arteriosclerosisHisanori Kosuge
Department of Cardiovascular Medicine, Tokyo Medical and Dental University, 1 5 45, Yushima, Bunkyo ku, Tokyo 113 8519, Japan
Arterioscler Thromb Vasc Biol 26:2660-5. 2006..However, the effect of costimulatory molecules on the formation of neointimal hyperplasia has not been fully elucidated. We examined the role of the ICOS pathway in SMC proliferation...
- Mesenchymal cells are required for functional development of thymic epithelial cellsManami Itoi
Department of Immunology and Microbiology, Meiji University of Oriental Medicine, Hiyoshi cho, Nantan, Kyoto 629 0392, Japan
Int Immunol 19:953-64. 2007..In addition, our data suggest that mesenchymal cells are required to create the thymic microenvironment and to maintain epithelial architecture and function...
- Infection of class II-deficient mice by the DA strain of Theiler's virusL Fiette
Unite des Virus Lents, URA 1157 Centre National de la Recherche Scientifique, Institut Pasteur, France
J Virol 70:4811-5. 1996..However, these foci are smaller and contain fewer demyelinated axons than those observed in susceptible SJL/J or beta2m-/- mice...
- Distinct MHC class II molecules are associated on the dendritic cell surface in cholesterol-dependent membrane microdomainsSanjay Khandelwal
Experimental Immunology Branch, NCI, National Institutes of Health, Bethesda, Maryland 20892, USA
J Biol Chem 285:35303-10. 2010....
- Antigen-presenting dendritic cells rescue CD4-depleted CCR2-/- mice from lethal Histoplasma capsulatum infectionWendy A Szymczak
Division of Infectious Diseases, University of Cincinnati, 231 Albert Sabin Way, Cincinnati, OH 45267, USA
Infect Immun 78:2125-37. 2010..Furthermore, CD4(+) T cells had a deleterious impact on immunity in infected CCR2(-/-) mice...
- Nucleotide sequence of a light chain gene of the mouse I-A subregion: A beta dM Malissen
Science 221:750-4. 1983..Sequence comparisons have been made to other proteins involved in immune responses and the consequent implications for the evolutionary relationships of these genes are discussed...
- Helper requirements for generation of effector CTL to islet beta cell antigensGeorg M N Behrens
Immunology Division, Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria, Australia
J Immunol 172:5420-6. 2004..This provides insight into the helper requirements for adoptive transfer immunotherapy of tumors and suggests key points for inhibition of CTL-mediated autoimmunity...
- Arthritis induced by posttranslationally modified (citrullinated) fibrinogen in DR4-IE transgenic miceJonathan A Hill
Department of Microbiology and Immunology, University of Western Ontario, London, Ontario, Canada, N6A 5C1
J Exp Med 205:967-79. 2008..These observations directly implicate citrullinated fibrinogen as arthritogenic in the context of RA-associated MHC class II molecules...
- The expression of I-A correlates with the uptake of interferon-gamma by macrophagesA Celada
La Jolla Cancer Research Foundation, CA 92037
Eur J Immunol 19:205-8. 1989....
- Epitope affinity for MHC class I determines helper requirement for CTL primingA Franco
Division of Immunochemistry, La Jolla Institute for Allergy and Immunology, San Diego, CA 92121, USA
Nat Immunol 1:145-50. 2000..Depending on the epitope, one source of help was much more efficient than the other...
- Response of murine gamma delta T cells to the synthetic polypeptide poly-Glu50Tyr50C T Cady
Department of Immunology, National Jewish Medical and Research Center, Denver, CO 80206, USA
J Immunol 165:1790-8. 2000..Direct stimulation by ligands resembling pE50Y50 may thus selectively evoke contributions of gamma delta T cells to the host response...
- Skin-resident murine dendritic cell subsets promote distinct and opposing antigen-specific T helper cell responsesBotond Z Igyarto
Department of Dermatology, Center for Immunology, University of Minnesota, Minneapolis, MN 55455, USA
Immunity 35:260-72. 2011..Langerin(+) dDCs also inhibited the ability of LCs and classic DCs to promote Th17 cell responses. This work demonstrates that skin-resident DC subsets promote distinct and opposing antigen-specific responses...
- The generation of protective memory-like CD8+ T cells during homeostatic proliferation requires CD4+ T cellsSara E Hamilton
Department of Laboratory Medicine and Pathology, University of Minnesota Medical Center, Center for Immunology, Minneapolis, Minnesota 55454, USA
Nat Immunol 7:475-81. 2006..Thus, like conventional CD8(+) memory T cells, the protective function of HP-memory CD8(+) T cells shows dependence on CD4(+) T cell help...
- Gamma delta T cell homeostasis is controlled by IL-7 and IL-15 together with subset-specific factorsRoberto Baccala
Department of Immunology, The Scripps Research Institute, La Jolla, CA 92037, USA
J Immunol 174:4606-12. 2005..Thus, gamma delta T cell homeostasis is maintained by trophic cytokines commonly used by other types of lymphoid cells, as well as by additional, as yet unidentified, gamma delta-specific factors...
- CCR6 regulates CD4+ T-cell-mediated acute graft-versus-host disease responsesRosa Varona
Departamento de Inmunologia y Oncologia, Centro Nacional de Biotecnologia CSIC, Universidad Autonoma de Madrid, Cantoblanco, Madrid, Spain
Blood 106:18-26. 2005..We suggest a role for CCR6 in recruiting alloreactive CD4+ T cells to target tissues and identify CCR6 as a potential therapeutic target for GvHD...
- Constitutive activation of STAT5 supersedes the requirement for cytokine and TCR engagement of CD4+ T cells in steady-state homeostasisDevon K Taylor
Department of Medicine, University of Pennsylvania, 415 Curie Boulevard, Philadelphia, PA 19104, USA
J Immunol 177:2216-23. 2006..This suggests that the need for TCR stimulation to induce common gamma-chain cytokine receptor expression, and thus STAT5 activation, is a key factor in maintaining normal CD4+ T cell homeostasis...
- CD70 signaling is critical for CD28-independent CD8+ T cell-mediated alloimmune responses in vivoAkira Yamada
Transplantation Research Center, Brigham and Women s Hospital and Children s Hospital Boston, Harvard Medical School, Boston, MA 02115, USA
J Immunol 174:1357-64. 2005..These novel findings have important implications for the development of transplantation tolerance-inducing strategies in primates and humans, in which CD8(+) T cell depletion is currently mandatory...
- The contribution of I-Abm12 to phenotypic and functional alterations among T-cell subsets in NZB miceM Naiki
Division of Rheumatology, Allergy and Clinical Immunology, University of California, School of Medicine, Davis 95616
J Autoimmun 6:131-43. 1993..C-H-2bm12 mice compared to C57BL/6 (H-2b) mice. These data further highlight the influence of I-A on autoimmunity and in particular the influence of the bm12 mutation on altering the natural history of disease expression in NZB mice...
- Molecular analysis of the pathogenesis of autoimmune insulitis in NOD miceY Koide
Department of Microbiology Immunology, Hamamatsu University School of Medicine, Japan
Tohoku J Exp Med 173:157-70. 1994..Of the diabetes-susceptibility genes, only in the case of Idd-1 is there any evidence for the identity of the gene products. ILI mice should provide more information on the products of the other diabetes-susceptibility genes of NOD mice...
- Murine Vbeta3+ and Vbeta7+ T cell subsets are specific targets for the HERV-K18 Env superantigenAlbert K Tai
Department of Pathology, Tufts University School of Medicine, Boston, MA 02111, USA
J Immunol 177:3178-84. 2006..The definition of the murine Vbeta specificity and the establishment of a transgenic model will permit the investigation of the role of this superantigen in the life cycle of EBV and its implicated diseases...
- Establishment of the major compatibility complex-dependent development of CD4+ and CD8+ T cells by the Cbl family proteinsFang Huang
Department of Microbiology, Columbia University College of Physicians and Surgeons, 701 West 168th Street, New York, New York 10032, USA
Immunity 25:571-81. 2006..They likely do so by suppressing MHC-independent NF-kappaB activation, possibly through downmodulating pre-TCR signaling in DP thymocytes...
- Murine I-A beta chain polymorphism: nucleotide sequences of three allelic I-A beta genesE Choi
Science 221:283-6. 1983..The differences were found to be a series of short alterations clustered in the amino terminal half of the polypeptide...
- Host responses to intestinal microbial antigens in gluten-sensitive miceJane M Natividad
Farncombe Family Digestive Health Research Institute, McMaster University, Hamilton, Canada
PLoS ONE 4:e6472. 2009..The aim of this study was to investigate whether intestinal barrier dysfunction induced by indomethacin treatment affects the host response to intestinal microbiota in gluten-sensitized HLA-DQ8/HCD4 mice...
- Themis, a T cell-specific protein important for late thymocyte developmentRenaud Lesourne
Laboratory of Mammalian Genes and Development, Eunice Kennedy Shriver National Institute of Child Health and Human Development, Bethesda, Maryland, USA
Nat Immunol 10:840-7. 2009..Our results identify Themis as a critical component of the T cell developmental program and suggest that Themis functions to sustain and/or integrate signals required for proper lineage commitment and maturation...
- Mechanisms by which the I-ABM12 mutation influences susceptibility to experimental myasthenia gravis: a study in homozygous and heterozygous miceP I Karachunski
Department of Biochemistry, College of Biological Sciences, University of Minnesota, St Paul 55108, USA
Scand J Immunol 42:215-25. 1995..This is probably related to the absence of CD4+ cells sensitized to epitopes within the sequence T alpha 150-160, consequent to the inability of the I-Abm12 molecule to present this sequence...
- CD40 engagement on dendritic cells, but not on B or T cells, is required for long-term control of murine gammaherpesvirus 68Francesca Giannoni
Viral Immunology, Torrey Pines Institute for Molecular Studies, 3550 General Atomics Court, San Diego, CA 92121, USA
J Virol 82:11016-22. 2008..Taken together, our data suggest that CD40 engagement on DC, but not on T or B cells, is essential for effective long-term control of MHV-68...
- TRAIL deficiency does not rescue impaired CD8+ T cell memory generated in the absence of CD4+ T cell helpJilian A Sacks
Department of Immunology and Howard Hughes Medical Institute, University of Washington, Seattle, WA 98195, USA
J Immunol 180:4570-6. 2008..Overall, our results suggest that CD4(+) T cell help for the CD8(+) T cell response is not contingent on the silencing of TRAIL expression and prevention of TRAIL-mediated apoptosis...
- CD8+ but not CD4+ T cells require cognate interactions with target tissues to mediate GVHD across only minor H antigens, whereas both CD4+ and CD8+ T cells require direct leukemic contact to mediate GVLCatherine Matte-Martone
Section of Medical Oncology, Cancer Center, Yale University School of Medicine, New Haven, CT 06520 8032, USA
Blood 111:3884-92. 2008..Thus, CD4 cells use distinct effector mechanisms in GVHD and GVL: direct cytolytic action is required for GVL but not for GVHD. If these noncytolytic pathways can be inhibited, then GVHD might be ameliorated while preserving GVL...
- Presenilins regulate alphabeta T cell development by modulating TCR signalingKaren Laky
Laboratory of Cellular and Molecular Immunology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
J Exp Med 204:2115-29. 2007....
- Accelerated atherosclerosis in ApoE deficient lupus mouse modelsZhongjie Ma
Divisions of Rheumatology, Department of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA
Clin Immunol 127:168-75. 2008..These observations define a connection between induction of lupus-like symptoms and development of severe atherosclerosis in ApoE deficient lupus mouse models...
- Studies with MHC-deficient knock-out mice reveal impact of both MHC I- and MHC II-dependent T cell responses on Listeria monocytogenes infectionC H Ladel
Department of Immunology, University of Ulm, Germany
J Immunol 153:3116-22. 1994..monocytogenes and point to the necessity of a coordinated interaction between CD8 and CD4 alpha beta T cells (and probably gamma delta T cells) in anti-L. monocytogenes resistance...
- Role of B cells in pathogenesis of Collagen-induced Arthritis in Humanized MiceVeena Taneja; Fiscal Year: 2010..The information gained using this unique model may be instructive in developing preventive immunointervention for ongoing arthritis especially in women. ..
- Role of B cells in pathogenesis of Collagen-induced Arthritis in Humanized MiceVeena Taneja; Fiscal Year: 2010..The information gained using this unique model may be instructive in developing preventive immunointervention for ongoing arthritis especially in women. ..
- The vital role of BAFF in the development of SLEWilliam Stohl; Fiscal Year: 2007....
- The vital role of BAFF in the development of SLEWilliam Stohl; Fiscal Year: 2010..abstract_text> ..
- Multimodality Therapy for Metastatic Breast CancerJonathan Serody; Fiscal Year: 2006..The long-term goals of this work are to evaluate safe and effective therapies that induce a complete remission for the treatment of women with metastatic breast cancer. ..
- Treg Migration in GVHDJonathan Serody; Fiscal Year: 2007..The overall goals of this work are to provide a better understanding of the mechanism of activity of Treg cells prior to a clinical trial evaluating their effects in blocking GVHD. ..
- Pneumococcal immunization through a novel mechanismRichard Malley; Fiscal Year: 2007....
- Analysis of CD81-PGRL complex on T cellsSTEPHEN CHAPES; Fiscal Year: 2007..The coordinated effect of CD81, PGRL and EP3 on T cell integrin activity measured by adhesion to or motility on ICAMs. ..
- Mechanisms of Immunity to Pneumococcal ColonizationRichard Malley; Fiscal Year: 2007..The results of our experiments will define a previously-unrecognized mechanism of protection against extracellular encapsulated bacteria and help in the development of novel vaccines against pneumococcus. ..
- Treg Migration in GVHDJonathan Serody; Fiscal Year: 2009..The overall goals of this work are to provide a better understanding of the mechanism of activity of Treg cells prior to a clinical trial evaluating their effects in blocking GVHD. ..
- Mechanisms of Immunity to Pneumococcal ColonizationRichard Malley; Fiscal Year: 2010..The results of our experiments will define a previously-unrecognized mechanism of protection against extracellular encapsulated bacteria and help in the development of novel vaccines against pneumococcus. ..
- Mechanisms of Immunity to Pneumococcal ColonizationRichard Malley; Fiscal Year: 2009..The results of our experiments will define a previously-unrecognized mechanism of protection against extracellular encapsulated bacteria and help in the development of novel vaccines against pneumococcus. ..
- Pneumococcal immunization through a novel mechanismRichard Malley; Fiscal Year: 2010..abstract_text> ..
- Pneumolysin, Innate and Acquired Immunity to PneumococciRichard Malley; Fiscal Year: 2005..The establishment of a link between the innate and the acquired arm of the immune response to pneumococcus may provide a better understanding of the mechanisms by which immunity to pneumococcus is acquired. ..
- Mechanisms Involved in T cell trafficking in GVHDJonathan Serody; Fiscal Year: 2007..We will evaluate if small peptides that could be used clinically are effective in blocking the occurrence of GVHD as a prelude to their use in phase I clinical trials. ..
- Natural IgM antilymphocyte autoantibodies inhibit HIV-1PETER LOBO; Fiscal Year: 2003..A successful outcome with the proposed studies could better our understanding on pathogenesis of H1V-1 infection and may provide strategies to prolong the asymptomatic state after HIV-1 infection. ..
- Vector and Host Contributions to the Regulation of E. chaffeensis Gene ExpressionROMAN GANTA; Fiscal Year: 2009..chaffeensis gene regulation and how the rickettsiale in macrophages and tick cells respond to the loss of expression from a differentially expressed protein. ..
- APOPTOSIS-MODIFIED SELF ANTIGEN IN RHEUMATIC DISEASEEric Greidinger; Fiscal Year: 2002..In the future, this work may lead to the development of specific immunotherapy strategies for the treatment of Ul-70kDa-associated rheumatic disorders. ..
- MECHANISMS OF SYNERGISTIC REGULATION OF STEM/PROGENITORSHal E Broxmeyer; Fiscal Year: 2010....
- Immune Response to Small Nuclear Ribonucleoprotein AutoantigensEric L Greidinger; Fiscal Year: 2010..Our research goal is to develop new and effective treatments of these disorders. ..
- Vector and Host Contributions to the Regulation of E. chaffeensis Gene ExpressionRoman R Ganta; Fiscal Year: 2011..chaffeensis gene regulation and how the rickettsiale in macrophages and tick cells respond to the loss of expression from a differentially expressed protein. ..
- MECHANISMS OF SYNERGISTIC REGULATION OF STEM/PROGENITORSHal Broxmeyer; Fiscal Year: 2003..abstract_text> ..
- CHEMOKINES/CYTOKINES AND RECEPTORS IN STEM CELL HOMINGHal Broxmeyer; Fiscal Year: 2005..These studies should clarity the relevance of SDF-1 and CXCR4 for homing/engraftment and mobilization of primary stem/progenitor cells. ..
- Gene expression in non-functional CD8 T cellsSally Sarawar; Fiscal Year: 2005..The data are likely to lead to a new understanding of how CD8 T cells function in the control of persistent viral infections and mechanisms of CD8 T cell activation. ..
- Anti-Tumor Autoimmunity by lymphopenia T cell ExpansionRoberto Baccala; Fiscal Year: 2007..The results will define the role of homeostatic T cell proliferation in tumor autoimmunity, and provide new approaches to the treatment of cancer. ..
- Functional and Anatomical Characterization of the Hematopoietic Stem Cell NicheDeepta Bhattacharya; Fiscal Year: 2007..The goal of this proposal is to better characterize the properties of these niches and to determine how best to utilize these niches for bone marrow transplantation. ..
- Viral Decoy ReceptorsDaved Fremont; Fiscal Year: 2006..abstract_text> ..
- Interaction between influenza virus and H. influenzaeSally Sarawar; Fiscal Year: 2007..This could be particularly important during an influenza pandemic and may be more broadly applicable to other respiratory viruses. ..