Gene Symbol: H13
Description: histocompatibility 13
Alias: 1200006O09Rik, 4930443L17Rik, 5031424B04Rik, AV020344, H-13, Hm13, PSL3, Spp, minor histocompatibility antigen H13, presenilin-like aspartyl protease, presenilin-like protein 3, signal peptide peptidase beta
Species: mouse
Products:     H13

Top Publications

  1. Mendoza L, Paz P, Zuberi A, Christianson G, Roopenian D, Shastri N. Minors held by majors: the H13 minor histocompatibility locus defined as a peptide/MHC class I complex. Immunity. 1997;7:461-72 pubmed
    ..By expression cloning, we identified the H13 locus, a classical minor H locus first detected 30 years ago by the trait of graft rejection...
  2. Snell G, Cudkowicz G, Bunker H. Histocompatibility genes of mice. VII. H-13, a new histocompatibility locus in the fifth linkage group. Transplantation. 1967;5:492-503 pubmed
  3. Wood A, Roberts R, Monk D, Moore G, Schulz R, Oakey R. A screen for retrotransposed imprinted genes reveals an association between X chromosome homology and maternal germ-line methylation. PLoS Genet. 2007;3:e20 pubmed
    ..The striking correlation between imprinting and X chromosome provenance suggests that retrotransposed elements with homology to the X chromosome can be selectively targeted for methylation during mammalian oogenesis. ..
  4. Graff R, Martin Morgan D, Kurtz M. Multiplicity of chromosome 2 histocompatibility genes: new loci, H-44 and H-45. Immunogenetics. 1987;26:111-4 pubmed
  5. Wood A, Schulz R, Woodfine K, Koltowska K, Beechey C, Peters J, et al. Regulation of alternative polyadenylation by genomic imprinting. Genes Dev. 2008;22:1141-6 pubmed publisher
    ..We show that alternative polyadenylation sites at a novel murine imprinted gene (H13) are utilized in an allele-specific manner...
  6. Urny J, Hermans Borgmeyer I, Gercken G, Schaller H. Expression of the presenilin-like signal peptide peptidase (SPP) in mouse adult brain and during development. Gene Expr Patterns. 2003;3:685-91 pubmed
    ..that cleaves signal peptides within hydrophobic domains, and was, therefore, named signal peptide peptidase (SPP). We isolated cDNAs coding for mouse and human orthologues of SPP...
  7. Graff R, Hauptfeld V, Riordan K, Kurtz M. Continued mapping of chromosome 2 genes. Immunogenetics. 1994;40:21-6 pubmed
    ..The order of the bracketed genes is not known. H-44 maps centromeric to IR-H-Y. The genes encoding the antigens that stimulate lymphocyte clones 2G7, 2C10, 1F6, 1B10, and 1H10 map centromeric to H-45. ..
  8. Lembertas A, Perusse L, Chagnon Y, Fisler J, Warden C, Purcell Huynh D, et al. Identification of an obesity quantitative trait locus on mouse chromosome 2 and evidence of linkage to body fat and insulin on the human homologous region 20q. J Clin Invest. 1997;100:1240-7 pubmed
  9. De Angelis W, Haughton G. Detection of weak histocompatibility antigens on mouse peritoneal macrophages. Transplant Proc. 1971;3:202-6 pubmed

More Information


  1. Palm J, Heyner S, Brinster R. Differential immunofluorescence of fertilized mouse eggs with H-2 and non-H-2 antibody. J Exp Med. 1971;133:1282-93 pubmed
    ..The results suggest that the initial expression of histocompatibility genes varies and support the hypothesis that the appearance of these cell components may relate to specific stages of differentiation. ..
  2. Higuchi T, Maruyama T, Jaramillo A, Mohanakumar T. Induction of obliterative airway disease in murine tracheal allografts by CD8+ CTLs recognizing a single minor histocompatibility antigen. J Immunol. 2005;174:1871-8 pubmed
    ..Thus, the goal of this study was to define the role of a single mHAg mismatch at the polymorphic H13 allele in the development of obliterative airway disease (OAD) after murine heterotopic tracheal transplantation...
  3. Vojtiskova M, Poláčková M, Pokorna Z. Histocompatibility antigens on mouse spermatozoa. Folia Biol (Praha). 1969;15:322-32 pubmed
  4. Oliveira C, Querido B, Sluijter M, de Groot A, van der Zee R, Rabelink M, et al. New role of signal peptide peptidase to liberate C-terminal peptides for MHC class I presentation. J Immunol. 2013;191:4020-8 pubmed publisher
    The signal peptide peptidase (SPP) is an intramembrane cleaving aspartyl protease involved in release of leader peptide remnants from the endoplasmic reticulum membrane, hence its name...
  5. Chatzinikolaou G, Apostolou Z, Aid Pavlidis T, Ioannidou A, Karakasilioti I, Papadopoulos G, et al. ERCC1-XPF cooperates with CTCF and cohesin to facilitate the developmental silencing of imprinted genes. Nat Cell Biol. 2017;19:421-432 pubmed publisher
  6. Zuberi A, Dudley M, Christianson G, Roopenian D. Gene mapping in a murine cell line by immunoselection with cytotoxic T lymphocytes. Genomics. 1994;19:273-9 pubmed
    ..We suggest that Tc immunoselection against minor H antigens is a promising approach for targeting negative selection to specified chromosomal regions and can provide high-resolution genetic map information. ..
  7. Graff R, Kurtz M, Paul R, Martin D, Roopenian D. Additional mapping of mouse chromosome 2 genes. Immunogenetics. 1991;33:96-100 pubmed
    ..Hd-1 typing indicated that Hd-1 maps distal to [H-42, H-44] and proximal to un. The gene order [pa, B2m, H-3], we, [H-42, H-45], Hd-1, un, H-13, at, with H-44 mapping centromeric to Hd-1, is indicated by the data. ..
  8. Sackler A, Weltman A. Metabolic and endocrine differences between the mutation whirler and normal female mice. J Exp Zool. 1967;164:133-40 pubmed
  9. Ostrov D, Roden M, Shi W, Palmieri E, Christianson G, Mendoza L, et al. How H13 histocompatibility peptides differing by a single methyl group and lacking conventional MHC binding anchor motifs determine self-nonself discrimination. J Immunol. 2002;168:283-9 pubmed
    The mouse H13 minor histocompatibility (H) Ag, originally detected as a barrier to allograft transplants, is remarkable in that rejection is a consequence of an extremely subtle interchange, P4(Val/Ile), in a nonamer H2-D(b)-bound ..
  10. Urny J, Hermans Borgmeyer I, Schaller H. Cell-surface expression of a new splice variant of the mouse signal peptide peptidase. Biochim Biophys Acta. 2006;1759:159-65 pubmed
    The signal peptide peptidase (SPP) is an intramembrane-cleaving aspartyl protease that acts on type II transmembrane proteins. SPP substrates include signal peptides after they have been cleaved from a preprotein, hence the name...
  11. Graff R, Bailey D. The non-H-2 histocompatibility loci and their antigens. Transplant Rev. 1973;15:26-49 pubmed
  12. Huang Z, Han Z, Zhang F, He H, Yu S, Wu Q. Spatiotemporal expression of retrogene-host pair Mcts2/H13 in mouse embryo, and Mcts2 has no influence on H13 transcription pattern in NIH/3T3 cells. Acta Histochem. 2014;116:312-8 pubmed publisher
    Mcts2 and H13 comprise an imprinted retrogene-host gene pair. Imprinted genes have been proved to be closely related with embryo development...
  13. Graff R, Hildemann W, Snell G. Histocompatibility genes of mice. VI. Allografts in mice congenic at various non-H-2 histocompatibility loci. Transplantation. 1966;4:425-37 pubmed