Gsta4

Summary

Gene Symbol: Gsta4
Description: glutathione S-transferase, alpha 4
Alias: GST5.7, mGsta4, GST A4-4, GST class-alpha member 4, GSTA4-4, glutathione S-transferase 5.7, glutathione S-transferase A4
Species: mouse

Top Publications

  1. ncbi Physiological role of mGSTA4-4, a glutathione S-transferase metabolizing 4-hydroxynonenal: generation and analysis of mGsta4 null mouse
    Mark R Engle
    Department of Pharmacology and Toxicology, and Department of Biochemistry and Molecular Biology, University of Arkansas for Medical Sciences, and Central Arkansas Veterans Healthcare System, Little Rock, AR 72205, USA
    Toxicol Appl Pharmacol 194:296-308. 2004
  2. pmc Loss of glutathione S-transferase A4 accelerates obstruction-induced tubule damage and renal fibrosis
    Anlin Liang
    Nephrology Division, Baylor College of Medicine, Houston, TX, USA Department of Orthopaedics, First Affiliated Hospital of Chongqing Medical University, Chongqing, China
    J Pathol . 2012
  3. pmc Down-regulation of glutatione S-transferase α 4 (hGSTA4) in the muscle of thermally injured patients is indicative of susceptibility to bacterial infection
    Yiorgos Apidianakis
    Department of Surgery, Harvard Medical School, Boston, Massachusetts, USA
    FASEB J 26:730-7. 2012
  4. pmc A role for chromosomal protein HMGN1 in corneal maturation
    Yehudit Birger
    National Cancer Institute, Bethesda, MD 20892, USA
    Differentiation 74:19-29. 2006
  5. doi Role of the electrophilic lipid peroxidation product 4-hydroxynonenal in the development and maintenance of obesity in mice
    Sharda P Singh
    Department of Pharmacology and Toxicology, University of Arkansas for Medical Sciences, Little Rock, Arkansas 72205, USA
    Biochemistry 47:3900-11. 2008
  6. pmc 4-Hydroxynonenal induces p53-mediated apoptosis in retinal pigment epithelial cells
    Abha Sharma
    Department of Molecular Biology and Immunology, RES 416G, University of North Texas Health Science Center, 3500 Camp Bowie Boulevard, Fort Worth, TX 76107, USA
    Arch Biochem Biophys 480:85-94. 2008
  7. doi Protective role of glutathione S-transferase A4 induced in copper/zinc-superoxide dismutase knockout mice
    Daisaku Yoshihara
    Department of Biochemistry, Hyogo College of Medicine, 1 1 Mukogawa cho, Nishinomiya, Hyogo 663 8501, Japan
    Free Radic Biol Med 47:559-67. 2009
  8. pmc Disruption of the mGsta4 gene increases life span of C57BL mice
    Sharda P Singh
    Department of Pharmacology and Toxicology, University of Arkansas for Medical Sciences, 4301 West Markham Street, Little Rock, AR 72205, USA
    J Gerontol A Biol Sci Med Sci 65:14-23. 2010
  9. pmc Downregulation of adipose glutathione S-transferase A4 leads to increased protein carbonylation, oxidative stress, and mitochondrial dysfunction
    Jessica M Curtis
    Department of Biochemistry, Molecular Biology and Biophysics, The University of Minnesota, Minneapolis, Minnesota, USA
    Diabetes 59:1132-42. 2010
  10. pmc Genetic analysis of cytoprotective functions supported by graded expression of Keap1
    Keiko Taguchi
    Department of Medical Biochemistry, Tohoku University Graduate School of Medicine, 2 1 Seiryo cho, Aoba ku, Sendai, Miyagi, 980 8575, Japan
    Mol Cell Biol 30:3016-26. 2010

Research Grants

Scientific Experts

  • Andrei Bakin
  • M Yamamoto
  • Yogesh C Awasthi
  • Piotr Zimniak
  • Sharda P Singh
  • Fabienne Desmots
  • Yiorgos Apidianakis
  • Anlin Liang
  • Lin Lin
  • Keiko Taguchi
  • Jessica M Curtis
  • Rajendra Sharma
  • Erika L Abel
  • Ludwika Zimniak
  • Deepti Saini
  • Marie Anne Robin
  • Daisaku Yoshihara
  • Maciej Niemczyk
  • Haider Raza
  • Abha Sharma
  • Takafumi Suzuki
  • Sanjay Awasthi
  • Yehudit Birger
  • Vincent P Kelly
  • P Zimniak
  • Mark R Engle
  • Pascal Loyer
  • Andre Guillouzo
  • Fabrice Morel
  • Narayan G Avadhani
  • Ann Gustafsson
  • Lauren E Woodard
  • Wenzhong Xiao
  • Ronald G Tompkins
  • G J Kargul
  • Jie Du
  • William E Mitch
  • Weihong Xu
  • Matthew H Wilson
  • George P Tegos
  • Laurence G Rahme
  • Yun Wang
  • Yok Ai Que
  • Michael R Hamblin
  • Jizhong Cheng
  • Keqing Zhao
  • Chunquan Zheng
  • Luping Zhang
  • Cuidi Da
  • Xin Xu
  • Brian M Wiczer
  • Vladimir Sadovov
  • Sara S Strom
  • Maria D Person
  • Li E Wang
  • Katherine Cianflone
  • Olga Ilkayeva
  • David W Graham
  • Laura Langfield
  • Wendy S Wright
  • Paul A Grimsrud
  • David A Bernlohr
  • Jonathan M Maher
  • Qingyi Wei
  • Yukie Kawatani
  • Jonathan R Brestoff
  • Edgar A Arriaga
  • Deborah E Muoio
  • Penny K Riggs
  • Rocio E Foncea
  • John DiGiovanni
  • Hozumi Motohashi
  • Herng Hsiang Lo
  • Joe M Angel
  • Shinsuke Kato
  • Noriko Fujiwara
  • Keiichiro Suzuki
  • Hironobu Eguchi
  • Shunichi Yokoe
  • Haruhiko Sakiyama
  • Tomomi Ookawara
  • Prince V S Jeyabal
  • B Xiao
  • Rit Vatsyayan
  • Virginia Pearce
  • Pankaj Chaudhary
  • Eyal Rand
  • Joram Piatigorsky
  • Janine Davis
  • U Krengel

Detail Information

Publications26

  1. ncbi Physiological role of mGSTA4-4, a glutathione S-transferase metabolizing 4-hydroxynonenal: generation and analysis of mGsta4 null mouse
    Mark R Engle
    Department of Pharmacology and Toxicology, and Department of Biochemistry and Molecular Biology, University of Arkansas for Medical Sciences, and Central Arkansas Veterans Healthcare System, Little Rock, AR 72205, USA
    Toxicol Appl Pharmacol 194:296-308. 2004
    ..This reaction is catalyzed by specialized glutathione S-transferases (GSTs) exemplified by the murine mGSTA4-4...
  2. pmc Loss of glutathione S-transferase A4 accelerates obstruction-induced tubule damage and renal fibrosis
    Anlin Liang
    Nephrology Division, Baylor College of Medicine, Houston, TX, USA Department of Orthopaedics, First Affiliated Hospital of Chongqing Medical University, Chongqing, China
    J Pathol . 2012
    Glutathione transferase isozyme A4 (GSTA4) exhibits high catalytic efficiency to metabolize 4-hydroxynonenal (4-HNE), a highly reactive lipid peroxidation product that has been implicated in the pathogenesis of various chronic diseases...
  3. pmc Down-regulation of glutatione S-transferase α 4 (hGSTA4) in the muscle of thermally injured patients is indicative of susceptibility to bacterial infection
    Yiorgos Apidianakis
    Department of Surgery, Harvard Medical School, Boston, Massachusetts, USA
    FASEB J 26:730-7. 2012
    ..we demonstrate that the presence of a burn wound dramatically affects expression of both human (hGSTA4) and mouse (mGsta4) 4HNE scavengers...
  4. pmc A role for chromosomal protein HMGN1 in corneal maturation
    Yehudit Birger
    National Cancer Institute, Bethesda, MD 20892, USA
    Differentiation 74:19-29. 2006
    ..We suggest that interaction of HMGN1 with chromatin modulates the fidelity of gene expression and affects corneal development and maturation...
  5. doi Role of the electrophilic lipid peroxidation product 4-hydroxynonenal in the development and maintenance of obesity in mice
    Sharda P Singh
    Department of Pharmacology and Toxicology, University of Arkansas for Medical Sciences, Little Rock, Arkansas 72205, USA
    Biochemistry 47:3900-11. 2008
    ..In this paper, we report that disruption of mGsta4, a gene encoding the 4-HNE-conjugating enzyme mGSTA4-4, causes increased 4-HNE tissue levels and is accompanied by ..
  6. pmc 4-Hydroxynonenal induces p53-mediated apoptosis in retinal pigment epithelial cells
    Abha Sharma
    Department of Molecular Biology and Immunology, RES 416G, University of North Texas Health Science Center, 3500 Camp Bowie Boulevard, Fort Worth, TX 76107, USA
    Arch Biochem Biophys 480:85-94. 2008
    ..Our results also show that the induction of p53 in tissues of mGsta4 (-/-) mice correlate with elevated levels of 4-HNE due to its impaired metabolism...
  7. doi Protective role of glutathione S-transferase A4 induced in copper/zinc-superoxide dismutase knockout mice
    Daisaku Yoshihara
    Department of Biochemistry, Hyogo College of Medicine, 1 1 Mukogawa cho, Nishinomiya, Hyogo 663 8501, Japan
    Free Radic Biol Med 47:559-67. 2009
    ..A gene remarkably elevated in SOD1 KO mouse kidneys was identified as the glutathione S-transferase Alpha 4 gene (Gsta4), which encodes the GSTA4 subunit...
  8. pmc Disruption of the mGsta4 gene increases life span of C57BL mice
    Sharda P Singh
    Department of Pharmacology and Toxicology, University of Arkansas for Medical Sciences, 4301 West Markham Street, Little Rock, AR 72205, USA
    J Gerontol A Biol Sci Med Sci 65:14-23. 2010
    ..of 4-HNE disposal is via glutathione conjugation, in the mouse catalyzed primarily by glutathione transferase mGSTA4-4. Unexpectedly, mGsta4-null mice, in which 4-HNE detoxification is impaired, have an extended life span...
  9. pmc Downregulation of adipose glutathione S-transferase A4 leads to increased protein carbonylation, oxidative stress, and mitochondrial dysfunction
    Jessica M Curtis
    Department of Biochemistry, Molecular Biology and Biophysics, The University of Minnesota, Minneapolis, Minnesota, USA
    Diabetes 59:1132-42. 2010
    ..The primary enzymatic method for lipid aldehyde detoxification is via glutathione S-transferase A4 (GSTA4) dependent glutathionylation...
  10. pmc Genetic analysis of cytoprotective functions supported by graded expression of Keap1
    Keiko Taguchi
    Department of Medical Biochemistry, Tohoku University Graduate School of Medicine, 2 1 Seiryo cho, Aoba ku, Sendai, Miyagi, 980 8575, Japan
    Mol Cell Biol 30:3016-26. 2010
    ..These results support our contention that the benefits of Nrf2 activation in acute toxicity are hormetic and that constitutive Nrf2 activation beyond a certain threshold is rather disadvantageous to long-term survival...
  11. doi 2-Aminoethoxydiphenyl borate administration into the nostril alleviates murine allergic rhinitis
    Lin Lin
    Department of Otorhinolaryngology Head and Neck Surgery, Huashan Hospital of Fudan University, Shanghai, China
    Am J Otolaryngol 32:318-28. 2011
    ..In this study, we examined whether the intervention of Orai1 pathway was capable of controlling IgE-mediated allergic reactions by using AR mice models...
  12. pmc Evidence that Gsta4 modifies susceptibility to skin tumor development in mice and humans
    Erika L Abel
    Department of Carcinogenesis, Science Park Research Division, The University of Texas M D Anderson Cancer Center, Smithville, TX, USA
    J Natl Cancer Inst 102:1663-75. 2010
    ..Here, we used the mouse two-stage skin carcinogenesis model to identify the gene(s) responsible for the effects of Psl1...
  13. ncbi Activation of C-Jun N-terminal kinase is required for glutathione transferase A4 induction during oxidative stress, not during cell proliferation, in mouse hepatocytes
    Fabienne Desmots
    INSERM U620, Universite de Rennes I, IFR140, France
    FEBS Lett 579:5691-6. 2005
    Expression of the mouse glutathione transferase Alpha 4 (mGSTA4) has been studied during hepatocyte isolation and in cultured hepatocytes...
  14. pmc The distal sequence element of the selenocysteine tRNA gene is a tissue-dependent enhancer essential for mouse embryogenesis
    Vincent P Kelly
    Center for TARA, University of Tsukuba, 1 1 1 Tennoudai, Tsukuba 305 8577, Japan
    Mol Cell Biol 25:3658-69. 2005
    ..Together, our data demonstrate that the DSE is a tissue-dependent regulatory element of tRNA(Sec) expression and that its activity is vital for sufficient tRNA(Sec) production during mouse embryogenesis...
  15. ncbi Smad3-ATF3 signaling mediates TGF-beta suppression of genes encoding Phase II detoxifying proteins
    Andrei V Bakin
    Department of Cancer Genetics, Roswell Park Cancer Institute, Buffalo, NY 14263, USA
    Free Radic Biol Med 38:375-87. 2005
    ....
  16. pmc Characterization of a novel glutathione S-transferase isoenzyme from mouse lung and liver having structural similarity to rat glutathione S-transferase 8-8
    R D Medh
    Department of Human Biological Chemistry and Genetics, University of Texas Medical Branch, Galveston 77550
    Biochem J 278:793-9. 1991
    ..These studies suggest that mouse GST 5.7 structurally corresponds to rat GST 8-8 and belongs to the Alpha class...
  17. ncbi Estimation of genomic complexity, heterologous expression, and enzymatic characterization of mouse glutathione S-transferase mGSTA4-4 (GST 5.7)
    P Zimniak
    Department of Medicine, University of Arkansas for Medical Sciences, Little Rock
    J Biol Chem 269:992-1000. 1994
    We have previously isolated a cDNA clone for a unique mouse lung glutathione S-transferase, mGSTA4-4 (GST 5.7) (Zimniak, P., Eckles, M. A., Saxena, M., and Awasthi, Y. C. (1992) FEBS Lett. 313, 173-176)...
  18. ncbi Crystal structure of a murine alpha-class glutathione S-transferase involved in cellular defense against oxidative stress
    U Krengel
    BIOSON Research Institute, Department of Chemistry, University of Groningen, The Netherlands
    FEBS Lett 422:285-90. 1998
    ..Here, we report the crystal structure of murine GSTA4-4, which is the first structure of a prototypical member of this subgroup...
  19. ncbi Characterization of genes which exhibit reduced expression during the retinoic acid-induced differentiation of F9 teratocarcinoma cells: involvement of cyclin D3 in RA-mediated growth arrest
    T N Faria
    Department of Pharmacology, Cornell University Medical College, New York, NY 10021, USA
    Mol Cell Endocrinol 143:155-66. 1998
    ....
  20. ncbi Crystal structure of a murine glutathione S-transferase in complex with a glutathione conjugate of 4-hydroxynon-2-enal in one subunit and glutathione in the other: evidence of signaling across the dimer interface
    B Xiao
    ABL Basic Research Program, NCI Frederick Cancer Research and Development Center, Maryland 21702, USA
    Biochemistry 38:11887-94. 1999
    b>mGSTA4-4, a murine glutathione S-transferase (GST) exhibiting high activity in conjugating the lipid peroxidation product 4-hydroxynon-2-enal (4-HNE) with glutathione (GSH), was crystallized in complex with the GSH conjugate of 4-HNE (GS-..
  21. ncbi Verification and initial annotation of the NIA mouse 15K cDNA clone set
    G J Kargul
    Nat Genet 28:17-8. 2001
  22. ncbi Hybridization of alpha class subunits generating a functional glutathione transferase A1-4 heterodimer
    Ann Gustafsson
    Department of Biochemistry, Uppsala University, Biomedical Center, SE 751 23 Uppsala, Sweden
    J Mol Biol 316:395-406. 2002
    ..The non-additive kinetic properties of the subunits in the heterodimer therefore highlight the importance of fine-tuned subunit interactions for optimal catalytic efficiency of GST A1-1 and GST A4-4...
  23. ncbi Pro-inflammatory cytokines tumor necrosis factor alpha and interleukin-6 and survival factor epidermal growth factor positively regulate the murine GSTA4 enzyme in hepatocytes
    Fabienne Desmots
    INSERM U456, Faculte de Pharmacie, Universite de Rennes I, 35043 Rennes Cedex, France
    J Biol Chem 277:17892-900. 2002
    ..Using confocal microscopy immunolocalization and subcellular fractionation, mGSTA4 was demonstrated in both mitochondria and cytosol and found preferentially increased in cytosol during liver ..
  24. pmc Multiple isoforms of mitochondrial glutathione S-transferases and their differential induction under oxidative stress
    Haider Raza
    Department of Animal Biology and the Mari Lowe Center for Comparative Oncology, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, PA 19104 6047, U S A
    Biochem J 366:45-55. 2002
    ..S-transferase (GST) pool in mouse liver mitochondria, and have purified three distinct forms of GST: GSTA1-1 and GSTA4-4 of the Alpha family, and GSTM1-1 belonging to the Mu family...
  25. ncbi Phosphorylation enhances mitochondrial targeting of GSTA4-4 through increased affinity for binding to cytoplasmic Hsp70
    Marie Anne Robin
    Department of Animal Biology and the Mari Lowe Center for Comparative Oncology, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
    J Biol Chem 278:18960-70. 2003
    Recently we showed that three different isoforms of cytosolic glutathione S-transferases (GST), including GSTA4-4, are also localized in the mitochondrial compartment...
  26. ncbi A subgroup of class alpha glutathione S-transferases. Cloning of cDNA for mouse lung glutathione S-transferase GST 5.7
    P Zimniak
    Department of Medicine, University of Arkansas for Medical Sciences, Little Rock 72205
    FEBS Lett 313:173-6. 1992
    ..They share a substrate specificity profile that resembles pi-class enzymes, and are active in the conjugation of lipid peroxidation products...

Research Grants5

  1. Mechanisms of TGFbeta-mediated fibroblastic transition
    Andrei Bakin; Fiscal Year: 2006
    ..The proposed research will help to define the TGFbeta signaling network and will facilitate the design of novel selective inhibition of TGFbeta's tumor promoting activity. ..