Gsn

Summary

Gene Symbol: Gsn
Description: gelsolin
Alias: ADF, gelsolin, actin-depolymerizing factor, brevin
Species: mouse
Products:     Gsn

Top Publications

  1. Kangas H, Ulmanen I, Paunio T, Kwiatkowski D, Lehtovirta M, Jalanko A, et al. Functional consequences of amyloidosis mutation for gelsolin polypeptide -- analysis of gelsolin-actin interaction and gelsolin processing in gelsolin knock-out fibroblasts. FEBS Lett. 1999;454:233-9 pubmed
    b>Gelsolin, an actin-modulating protein, derived from a single gene exists in intracellular and secreted forms. A point mutation at position 187 of both forms of gelsolin causes familial amyloidosis of the Finnish type (FAF)...
  2. Yermen B, Tomas A, Halban P. Pro-survival role of gelsolin in mouse beta-cells. Diabetes. 2007;56:80-7 pubmed
    We have previously shown that the Ca(2+)-dependent actin-severing protein gelsolin plays an important role in regulated insulin secretion...
  3. Witke W, Li W, Kwiatkowski D, Southwick F. Comparisons of CapG and gelsolin-null macrophages: demonstration of a unique role for CapG in receptor-mediated ruffling, phagocytosis, and vesicle rocketing. J Cell Biol. 2001;154:775-84 pubmed
    ..The in vivo function of CapG, a calcium-sensitive barbed end capping protein and member of the gelsolin/villin family, has been assessed using a null Capg allele engineered into mice...
  4. Witke W, Sharpe A, Hartwig J, Azuma T, Stossel T, Kwiatkowski D. Hemostatic, inflammatory, and fibroblast responses are blunted in mice lacking gelsolin. Cell. 1995;81:41-51 pubmed
    b>Gelsolin, an 82 kDa actin-binding protein, has potent actin filament-severing activity in vitro...
  5. Serrander L, Skarman P, Rasmussen B, Witke W, Lew D, Krause K, et al. Selective inhibition of IgG-mediated phagocytosis in gelsolin-deficient murine neutrophils. J Immunol. 2000;165:2451-7 pubmed
    ..We have investigated the role of gelsolin, a calcium-dependent actin severing and capping protein, in peripheral blood neutrophils from gelsolin-null (Gsn-)..
  6. Chellaiah M, Kizer N, Silva M, Alvarez U, Kwiatkowski D, Hruska K. Gelsolin deficiency blocks podosome assembly and produces increased bone mass and strength. J Cell Biol. 2000;148:665-78 pubmed
    ..cytoskeletal reorganization and bone resorption by activating a heteromultimeric signaling complex that includes gelsolin, pp(60c-src), and phosphatidylinositol 3'-kinase...
  7. Kalwat M, Wiseman D, Luo W, Wang Z, Thurmond D. Gelsolin associates with the N terminus of syntaxin 4 to regulate insulin granule exocytosis. Mol Endocrinol. 2012;26:128-41 pubmed publisher
    ..In a screen to identify new Syn4-interacting factors, the calcium-activated F-actin-severing protein gelsolin was revealed...
  8. Crowley M, Head K, Kwiatkowski D, Asch H, Asch B. The mouse mammary gland requires the actin-binding protein gelsolin for proper ductal morphogenesis. Dev Biol. 2000;225:407-23 pubmed
    b>Gelsolin is an actin-binding/severing protein expressed in intracellular and secreted forms. It is a major regulator of the form and function of the actin cytoskeleton in most all cells...
  9. Tomas A, Yermen B, Min L, Pessin J, Halban P. Regulation of pancreatic beta-cell insulin secretion by actin cytoskeleton remodelling: role of gelsolin and cooperation with the MAPK signalling pathway. J Cell Sci. 2006;119:2156-67 pubmed
    ..In addition, B1 cell expression of the calcium-dependent F-actin severing protein gelsolin is >100-fold higher than that of C3 cells...

More Information

Publications70

  1. West M, Antoniou A, Prescott A, Azuma T, Kwiatkowski D, Watts C. Membrane ruffling, macropinocytosis and antigen presentation in the absence of gelsolin in murine dendritic cells. Eur J Immunol. 1999;29:3450-5 pubmed
    Previous studies have shown that mice lacking the actin-severing and capping protein gelsolin have defects in leukocyte and platelet function...
  2. Endres M, Fink K, Zhu J, Stagliano N, Bondada V, Geddes J, et al. Neuroprotective effects of gelsolin during murine stroke. J Clin Invest. 1999;103:347-54 pubmed
    ..in the actin cytoskeleton, which may occur, in part, through the actions of the actin filament-severing protein gelsolin. We show that gelsolin-null neurons have enhanced cell death and rapid, sustained elevation of Ca2+ levels ..
  3. Lueck A, Brown D, Kwiatkowski D. The actin-binding proteins adseverin and gelsolin are both highly expressed but differentially localized in kidney and intestine. J Cell Sci. 1998;111 ( Pt 24):3633-43 pubmed
    To understand the distinct functions of the closely related actin-severing proteins adseverin and gelsolin, we examined the expression of these proteins in detail during mouse and human development using a new highly sensitive and ..
  4. Arora P, Wang Y, Janmey P, Bresnick A, Yin H, McCulloch C. Gelsolin and non-muscle myosin IIA interact to mediate calcium-regulated collagen phagocytosis. J Biol Chem. 2011;286:34184-98 pubmed publisher
    ..was temporally and spatially associated with actin assembly at nascent phagosomes, which was absent in gelsolin null cells...
  5. Mburu P, Romero M, Hilton H, Parker A, Townsend S, Kikkawa Y, et al. Gelsolin plays a role in the actin polymerization complex of hair cell stereocilia. PLoS ONE. 2010;5:e11627 pubmed publisher
    ..We show that the actin capping and severing protein, gelsolin, is a part of the whirlin complex...
  6. Arora P, Chan M, Anderson R, Janmey P, McCulloch C. Separate functions of gelsolin mediate sequential steps of collagen phagocytosis. Mol Biol Cell. 2005;16:5175-90 pubmed
    ..Whereas the binding step of collagen phagocytosis is facilitated by Ca2+-dependent, gelsolin-mediated severing of actin filaments, the regulation of the collagen internalization step is not defined...
  7. Arora P, Glogauer M, Kapus A, Kwiatkowski D, McCulloch C. Gelsolin mediates collagen phagocytosis through a rac-dependent step. Mol Biol Cell. 2004;15:588-99 pubmed
    The role of gelsolin, a calcium-dependent actin-severing protein, in mediating collagen phagocytosis, is not defined...
  8. Mejillano M, Kojima S, Applewhite D, Gertler F, Svitkina T, Borisy G. Lamellipodial versus filopodial mode of the actin nanomachinery: pivotal role of the filament barbed end. Cell. 2004;118:363-73 pubmed
    ..The knockdown phenotype was rescued by a CP mutant refractory to shRNA, but not by another barbed-end capper, gelsolin, demonstrating that the phenotype was specific for CP...
  9. Irving A, Wang D, Vasilevski O, Latchoumanin O, Kozer N, Clayton A, et al. Regulation of actin dynamics by protein kinase R control of gelsolin enforces basal innate immune defense. Immunity. 2012;36:795-806 pubmed publisher
    ..Here we showed that the antiviral protein kinase R (PKR) inhibited the key actin-modifying protein gelsolin to regulate actin dynamics and control cytoskeletal cellular functions under homeostatic conditions...
  10. Zhang Q, Li J, Dong N, Tang L, Zhu X, Sheng Z, et al. Burn injury induces gelsolin expression and cleavage in the brain of mice. Neuroscience. 2013;228:60-72 pubmed publisher
    b>Gelsolin is an actin filament-severing and capping protein, affecting cellular motility, adhesiveness and apoptosis. Whether it is expressed in the brain of burned mice has not yet been characterized...
  11. FLYNN K, Hellal F, Neukirchen D, Jacob S, Tahirovic S, Dupraz S, et al. ADF/cofilin-mediated actin retrograde flow directs neurite formation in the developing brain. Neuron. 2012;76:1091-107 pubmed publisher
    ..Our data indicate that a single family of actin regulatory proteins, ADF/Cofilin, provides the required control of actin retrograde flow and dynamics to form neurites...
  12. Ordija C, Chiou T, Yang Z, DeLoid G, de Oliveira Valdo M, Wang Z, et al. Free actin impairs macrophage bacterial defenses via scavenger receptor MARCO interaction with reversal by plasma gelsolin. Am J Physiol Lung Cell Mol Physiol. 2017;312:L1018-L1028 pubmed publisher
    ..Plasma gelsolin (pGSN), a protein that functions to bind and cleave actin, restored bacterial binding and uptake by both murine ..
  13. Pilz A, Moseley H, Peters J, Abbott C. Comparative mapping of mouse chromosome 2 and human chromosome 9q: the genes for gelsolin and dopamine beta-hydroxylase map to mouse chromosome 2. Genomics. 1992;12:715-9 pubmed
    ..Two genes that map to human chromosome 9q34, gelsolin (GSN) and dopamine beta-hydroxylase (DBH), have not previously been located in the mouse...
  14. Larson L, Arnaudeau S, Gibson B, Li W, Krause R, Hao B, et al. Gelsolin mediates calcium-dependent disassembly of Listeria actin tails. Proc Natl Acad Sci U S A. 2005;102:1921-6 pubmed
    ..The Ca2+-sensitive actin-severing protein gelsolin concentrates in the Listeria rocket tails at normal resting [Ca2+]i and disassociates from the tails when [Ca2+]i ..
  15. Li G, Shi Y, Chen Y, Sun M, Sader S, Maekawa Y, et al. Gelsolin regulates cardiac remodeling after myocardial infarction through DNase I-mediated apoptosis. Circ Res. 2009;104:896-904 pubmed publisher
    b>Gelsolin, a calcium-regulated actin severing and capping protein, is highly expressed in murine and human hearts after myocardial infarction and is associated with progression of heart failure in humans...
  16. Maniatis N, Harokopos V, Thanassopoulou A, Oikonomou N, Mersinias V, Witke W, et al. A critical role for gelsolin in ventilator-induced lung injury. Am J Respir Cell Mol Biol. 2009;41:426-32 pubmed publisher
    ..b>Gelsolin (GSN), an actin-binding protein and a substrate of caspase-3, was recently shown to play a major role in ..
  17. Leifeld L, Fink K, Debska G, Fielenbach M, Schmitz V, Sauerbruch T, et al. Anti-apoptotic function of gelsolin in fas antibody-induced liver failure in vivo. Am J Pathol. 2006;168:778-85 pubmed
    Apoptosis is a key mechanism underlying fulminant hepatic failure. The role of gelsolin in such apoptotic pathways is not well understood because both pro-apoptotic and anti-apoptotic effects have been reported in vitro, depending on the ..
  18. Shao Z, Lee X, Huang G, Sheng G, Henderson C, Louvard D, et al. LINGO-1 Regulates Oligodendrocyte Differentiation through the Cytoplasmic Gelsolin Signaling Pathway. J Neurosci. 2017;37:3127-3137 pubmed publisher
    ..discovered that anti-LINGO-1 antibody-promoted OPC differentiation was accompanied by upregulation of cytoplasmic gelsolin (cGSN), an abundant actin-severing protein involved in the depolymerization of actin filaments...
  19. Wang D, Naydenov N, Feygin A, Baranwal S, Kuemmerle J, Ivanov A. Actin-Depolymerizing Factor and Cofilin-1 Have Unique and Overlapping Functions in Regulating Intestinal Epithelial Junctions and Mucosal Inflammation. Am J Pathol. 2016;186:844-58 pubmed publisher
    ..Members of the actin-depolymerizing factor (ADF) and cofilin protein family play key roles in actin dynamics by mediating filament severing and polymerization...
  20. Mikami M, Zhang Y, Danielsson J, Joell T, Yong H, Townsend E, et al. Impaired Relaxation of Airway Smooth Muscle in Mice Lacking the Actin-Binding Protein Gelsolin. Am J Respir Cell Mol Biol. 2017;56:628-636 pubmed publisher
    ..However, the cellular mechanisms are not well understood. Gelsolin is a calcium-activated actin-severing and -capping protein found in many cell types, including ASM cells...
  21. Oikonomou N, Thanasopoulou A, Tzouvelekis A, Harokopos V, Paparountas T, Nikitopoulou I, et al. Gelsolin expression is necessary for the development of modelled pulmonary inflammation and fibrosis. Thorax. 2009;64:467-75 pubmed publisher
    ..b>Gelsolin, an actin-binding protein that modulates cytoskeletal dynamics, was recently highlighted as a likely disease ..
  22. Harms C, Bösel J, Lautenschlager M, Harms U, Braun J, Hörtnagl H, et al. Neuronal gelsolin prevents apoptosis by enhancing actin depolymerization. Mol Cell Neurosci. 2004;25:69-82 pubmed
    b>Gelsolin (gsn), an actin-severing protein, protects neurons from excitotoxic cell death via inactivation of membranous Ca(2+) channels. Its role during apoptotic cell death, however, has remained unclear...
  23. Nie D, Chen Z, Ebrahimi Fakhari D, Di Nardo A, Jülich K, Robson V, et al. The Stress-Induced Atf3-Gelsolin Cascade Underlies Dendritic Spine Deficits in Neuronal Models of Tuberous Sclerosis Complex. J Neurosci. 2015;35:10762-72 pubmed publisher
    ..b>Gelsolin, a known target of Atf3 transcriptional activity, is also upregulated...
  24. Kronenberg G, Gertz K, Baldinger T, Kirste I, Eckart S, Yildirim F, et al. Impact of actin filament stabilization on adult hippocampal and olfactory bulb neurogenesis. J Neurosci. 2010;30:3419-31 pubmed publisher
    ..Decreased actin turnover and rigidity of cytoskeletal structures have been associated with aging and cell death. Gelsolin is a Ca(2+)-activated actin-severing protein that is widely expressed throughout the adult mammalian brain...
  25. Kasahara M, Hayashi M, Tanaka K, Inoko H, Sugaya K, Ikemura T, et al. Chromosomal localization of the proteasome Z subunit gene reveals an ancient chromosomal duplication involving the major histocompatibility complex. Proc Natl Acad Sci U S A. 1996;93:9096-101 pubmed
    ..3 and 9q33-q34). These observations have implications in understanding the genomic organization of the present-day MHC and offer insights into the origin of the MHC. ..
  26. Ishizaki A, Fujita H, Kuzumaki N. Growth-inhibitory functions of a mutated gelsolin (His321) in NIH/3T3 mouse fibroblasts. Exp Cell Res. 1995;217:448-52 pubmed
    ..From the R1 cells, we cloned a mutated gelsolin gene His321 and have shown the inhibitory activity of His321 against EJ-NIH/3T3 tumors...
  27. He S, Pirity M, Wang W, Wolf L, Chauhan B, Cveklova K, et al. Chromatin remodeling enzyme Brg1 is required for mouse lens fiber cell terminal differentiation and its denucleation. Epigenetics Chromatin. 2010;3:21 pubmed publisher
    ..Brg1 is directly or indirectly involved in processes that degrade lens fiber cell chromatin. The presence of nuclei and other organelles generates scattered light incompatible with the optical requirements for the lens. ..
  28. Li C, Sathyamurthy A, Oldenborg A, Tank D, Ramanan N. SRF phosphorylation by glycogen synthase kinase-3 promotes axon growth in hippocampal neurons. J Neurosci. 2014;34:4027-42 pubmed publisher
    ..Thus, our findings reveal a novel phosphorylation and activation of SRF by GSK-3 that is critical for SRF-dependent axon growth in mammalian central neurons. ..
  29. Zhang J, Li M, Song M, Chen W, Mao J, Song L, et al. Clic1 plays a role in mouse hepatocarcinoma via modulating Annexin A7 and Gelsolin in vitro and in vivo. Biomed Pharmacother. 2015;69:416-9 pubmed publisher
    ..of Clic1 by RNA interference was able to markedly enhance the expression of tumor metastasis genes Annexin A7 and Gelsolin in vitro, and downregulation of Annexin A7 and Gelsolin also enhanced the expression of Clic1 in vitro and in ..
  30. Svanström A, Grantham J. The molecular chaperone CCT modulates the activity of the actin filament severing and capping protein gelsolin in vitro. Cell Stress Chaperones. 2016;21:55-62 pubmed publisher
    ..CCT has recently been shown to bind gelsolin, an actin filament severing protein that increases actin dynamics by generating filament ends for further actin ..
  31. Kim H, Falet H, Hoffmeister K, Hartwig J. Wiskott-Aldrich syndrome protein (WASp) controls the delivery of platelet transforming growth factor-?1. J Biol Chem. 2013;288:34352-63 pubmed publisher
    ..We conclude that WASp function restricts TGF-?1 secretion in a Cdc42- and Src family kinase-dependent manner and independently of actin assembly. ..
  32. Dieffenbach C, Sengupta D, Krause D, Sawzak D, Silverman R. Cloning of murine gelsolin and its regulation during differentiation of embryonal carcinoma cells. J Biol Chem. 1989;264:13281-8 pubmed
    The regulation of gelsolin levels during differentiation of the murine embryonal carcinoma cell line, PC-13, was investigated using nucleic acid and immunological probes...
  33. Mukherjee R, Yun J. Long chain acyl CoA synthetase 1 and gelsolin are oppositely regulated in adipogenesis and lipogenesis. Biochem Biophys Res Commun. 2012;420:588-93 pubmed publisher
    Our previous proteomics study revealed that long chain acyl CoA synthetase 1 (ACSL1) and gelsolin (GSN) are oppositely regulated in white adipose tissue of diet-induced obese rats...
  34. Nishimura H, Yerkes E, Hohenfellner K, Miyazaki Y, Ma J, Hunley T, et al. Role of the angiotensin type 2 receptor gene in congenital anomalies of the kidney and urinary tract, CAKUT, of mice and men. Mol Cell. 1999;3:1-10 pubmed
  35. Becker P, Kazi A, Wadgaonkar R, Pearse D, Kwiatkowski D, Garcia J. Pulmonary vascular permeability and ischemic injury in gelsolin-deficient mice. Am J Respir Cell Mol Biol. 2003;28:478-84 pubmed
    b>Gelsolin is a potent actin filament regulatory protein that controls cytoskeletal assembly and disassembly...
  36. Merrick B, Patterson R, Witcher L, He C, Selkirk J. Separation and sequencing of familiar and novel murine proteins using preparative two-dimensional gel electrophoresis. Electrophoresis. 1994;15:735-45 pubmed
    ..Thus, we have found that preparative 2-D PAGE serves as a powerful one-step purification method for protein isolation and characterization from an important in vitro murine model for the study of carcinogenesis. ..
  37. Sun H, Yamamoto M, Mejillano M, Yin H. Gelsolin, a multifunctional actin regulatory protein. J Biol Chem. 1999;274:33179-82 pubmed
  38. Godin J, Thomas N, Laguesse S, Malinouskaya L, Close P, Malaise O, et al. p27(Kip1) is a microtubule-associated protein that promotes microtubule polymerization during neuron migration. Dev Cell. 2012;23:729-44 pubmed publisher
    ..Thus, p27(Kip1) cell-autonomously controls nucleokinesis and neurite branching by regulating both actin and microtubule cytoskeletons. ..
  39. Khatri N, Sagar A, Peddada N, Choudhary V, Chopra B, Garg V, et al. Plasma gelsolin levels decrease in diabetic state and increase upon treatment with F-actin depolymerizing versions of gelsolin. J Diabetes Res. 2014;2014:152075 pubmed publisher
    The study aims to map plasma gelsolin (pGSN) levels in diabetic humans and mice models of type II diabetes and to evaluate the efficacy of gelsolin therapy in improvement of diabetes in mice...
  40. Arora P, Wang Y, Bresnick A, Dawson J, Janmey P, McCulloch C. Collagen remodeling by phagocytosis is determined by collagen substrate topology and calcium-dependent interactions of gelsolin with nonmuscle myosin IIA in cell adhesions. Mol Biol Cell. 2013;24:734-47 pubmed publisher
    ..collagen substrate topography, free intracellular calcium ion concentration ([Ca(2+)]i, and the association of gelsolin with nonmuscle myosin IIA (NMMIIA) at collagen adhesions are regulated to enable collagen phagocytosis...
  41. Zuchero J, Fu M, Sloan S, Ibrahim A, Olson A, Zaremba A, et al. CNS myelin wrapping is driven by actin disassembly. Dev Cell. 2015;34:152-67 pubmed publisher
    ..drives oligodendrocyte membrane spreading and myelin wrapping in vivo, and the actin disassembly factor gelsolin is required for normal wrapping...
  42. Verhelle A, Nair N, Everaert I, Van Overbeke W, Supply L, Zwaenepoel O, et al. AAV9 delivered bispecific nanobody attenuates amyloid burden in the gelsolin amyloidosis mouse model. Hum Mol Genet. 2017;26:1353-1364 pubmed publisher
    b>Gelsolin amyloidosis is a dominantly inherited, incurable type of amyloidosis. A single point mutation in the gelsolin gene (G654A is most common) results in the loss of a Ca2+  binding site in the second gelsolin domain...
  43. Weisser Thomas J, Kempelmann H, Nickenig G, Grohe C, Djoufack P, Fink K, et al. Influence of gelsolin deficiency on excitation contraction coupling in adult murine cardiomyocytes. J Physiol Pharmacol. 2015;66:373-83 pubmed
    ..Depolymerization of actin filaments by gelsolin (gsn) is involved in the organisation of the cytoskeleton by leading to a lower polymerization state...
  44. Gonçalves A, Dias N, Moransard M, Correia R, Pereira J, Witke W, et al. Gelsolin is required for macrophage recruitment during remyelination of the peripheral nervous system. Glia. 2010;58:706-15 pubmed publisher
    ..Such reorganization requires regulated severing and depolymerization of actin filaments. Gelsolin is an actin filament severing protein expressed in many cell types including Schwann cells...
  45. Olt J, Mburu P, Johnson S, Parker A, Kuhn S, Bowl M, et al. The actin-binding proteins eps8 and gelsolin have complementary roles in regulating the growth and stability of mechanosensory hair bundles of mammalian cochlear outer hair cells. PLoS ONE. 2014;9:e87331 pubmed publisher
    ..Recently, it was shown that the actin-binding protein gelsolin is expressed in the stereocilia of outer hair cells (OHCs) and in its absence they become long and straggly...
  46. Cantù C, Bosè F, Bianchi P, Reali E, Colzani M, Cantù I, et al. Defective erythroid maturation in gelsolin mutant mice. Haematologica. 2012;97:980-8 pubmed publisher
    ..One of the proteins controlling actin dynamics is gelsolin, a calcium-activated actin filament severing and capping protein...
  47. El Sayegh T, Arora P, Ling K, Laschinger C, Janmey P, Anderson R, et al. Phosphatidylinositol-4,5 bisphosphate produced by PIP5KIgamma regulates gelsolin, actin assembly, and adhesion strength of N-cadherin junctions. Mol Biol Cell. 2007;18:3026-38 pubmed
    ..or a cell-permeant peptide that mimics and competes for the PI(4,5)P2-binding region of the actin-binding protein gelsolin inhibited incorporation of actin monomers in response to N-cadherin ligation and reduced intercellular adhesion ..
  48. Dong J, Ying G, Liu X, Wang W, Wang Y, Ni Z, et al. Lesion-induced gelsolin upregulation in the hippocampus following entorhinal deafferentation. Hippocampus. 2006;16:91-100 pubmed
    b>Gelsolin is an actin-binding protein that regulates actin filament-severing and capping activity in the various processes of cell motilities...
  49. Rehklau K, Gurniak C, Conrad M, Friauf E, Ott M, Rust M. ADF/cofilin proteins translocate to mitochondria during apoptosis but are not generally required for cell death signaling. Cell Death Differ. 2012;19:958-67 pubmed publisher
    ..activity for apoptosis, we exposed mouse embryonic fibroblasts deficient for n-cofilin, ADF (actin depolymerizing factor), or all ADF/cofilin isoforms to well-characterized apoptosis inducers...
  50. Wang Q, Xie Y, Du Q, Wu X, Feng X, Mei L, et al. Regulation of the formation of osteoclastic actin rings by proline-rich tyrosine kinase 2 interacting with gelsolin. J Cell Biol. 2003;160:565-75 pubmed
    ..In this paper, we provide evidence that PYK2 directly interacts with gelsolin, an actin binding, severing, and capping protein essential for osteoclastic actin cytoskeletal organization...
  51. Wang Y, George S, Srinivasan K, Patnaik S, Khurana S. Actin reorganization as the molecular basis for the regulation of apoptosis in gastrointestinal epithelial cells. Cell Death Differ. 2012;19:1514-24 pubmed publisher
    ..this study we demonstrate for the first time, that deletion of two homologous actin-binding proteins, villin and gelsolin renders villus epithelial cells extremely sensitive to apoptosis...
  52. Li M, Cui F, Cheng Y, Han L, Wang J, Sun D, et al. Gelsolin: role of a functional protein in mitigating radiation injury. Cell Biochem Biophys. 2015;71:389-96 pubmed publisher
    The present study was conducted to explore the protective effect of exogenous gelsolin (GSN) in mice exposed to high-dose of radiation...
  53. Shou S, Scott V, Reed C, Hitzemann R, Stadler H. Transcriptome analysis of the murine forelimb and hindlimb autopod. Dev Dyn. 2005;234:74-89 pubmed
    ..05) suggesting that by E 12.5, unique gene combinations are being used during the differentiation of each autopod type. ..
  54. Plageman T, Yutzey K. Microarray analysis of Tbx5-induced genes expressed in the developing heart. Dev Dyn. 2006;235:2868-80 pubmed
    ..the genes, including nppa, photoreceptor cadherin, brain creatine kinase, hairy/enhancer-of-split related 2, and gelsolin. In situ hybridization analysis indicated overlapping expression of these genes with tbx5 in the embryonic mouse ..
  55. Wolf M, Zimmermann A, Görlich A, Gurniak C, Sassoè Pognetto M, Friauf E, et al. ADF/Cofilin Controls Synaptic Actin Dynamics and Regulates Synaptic Vesicle Mobilization and Exocytosis. Cereb Cortex. 2015;25:2863-75 pubmed publisher
    ..Genetic data on LIMK1, a negative regulator of actin-depolymerizing proteins of the ADF/cofilin family, suggest a role for ADF/cofilin in presynaptic function...
  56. Brackley K, Grantham J. Interactions between the actin filament capping and severing protein gelsolin and the molecular chaperone CCT: evidence for nonclassical substrate interactions. Cell Stress Chaperones. 2011;16:173-9 pubmed publisher
    ..Here, we identify the actin filament remodeling protein gelsolin as a CCT-binding partner, and although it does not behave as a classical folding substrate, gelsolin binds to CCT ..
  57. Chen Y, Hims M, Shetty R, Mull J, Liu L, Leyne M, et al. Loss of mouse Ikbkap, a subunit of elongator, leads to transcriptional deficits and embryonic lethality that can be rescued by human IKBKAP. Mol Cell Biol. 2009;29:736-44 pubmed publisher
    ..For the first time, we demonstrate that IKAP is crucial for both vascular and neural development during embryogenesis and that protein function is conserved between mouse and human. ..
  58. Arai M, Kwiatkowski D. Differential developmentally regulated expression of gelsolin family members in the mouse. Dev Dyn. 1999;215:297-307 pubmed
    The gelsolin family of actin-modulating proteins contains seven mammalian members of which three have similar domain structure and function: gelsolin, capG, and adseverin...
  59. Hammarfjord O, Falet H, Gurniak C, Hartwig J, Wallin R. Gelsolin-independent podosome formation in dendritic cells. PLoS ONE. 2011;6:e21615 pubmed publisher
    ..One such protein, gelsolin, which associates to podosomes, has been reported to be important for podosome formation and function in ..
  60. Martin P, Pardo J, Schill N, Jöckel L, Berg M, Froelich C, et al. Granzyme B-induced and caspase 3-dependent cleavage of gelsolin by mouse cytotoxic T cells modifies cytoskeleton dynamics. J Biol Chem. 2010;285:18918-27 pubmed publisher
    ..The present study shows that isolated mouse gzmB cleaves the actin-severing mouse protein, cytoplasmic gelsolin (c-gelsolin) in vitro...
  61. Mokalled M, Johnson A, Kim Y, Oh J, Olson E. Myocardin-related transcription factors regulate the Cdk5/Pctaire1 kinase cascade to control neurite outgrowth, neuronal migration and brain development. Development. 2010;137:2365-74 pubmed publisher
    ..These abnormalities were accompanied by dysregulation of the actin-severing protein gelsolin and Pctaire1 (Cdk16) kinase, which cooperates with Cdk5 to initiate a kinase cascade that governs cytoskeletal ..