Gsk3b

Summary

Gene Symbol: Gsk3b
Description: glycogen synthase kinase 3 beta
Alias: 7330414F15Rik, 8430431H08Rik, C86142, GSK-3, GSK-3beta, GSK3, GSK-3 beta, glycogen synthase kinase-3 beta, serine/threonine-protein kinase GSK3B
Species: mouse

Top Publications

  1. pmc Axin and GSK3- control Smad3 protein stability and modulate TGF- signaling
    Xing Guo
    Department of Pharmacology and Cancer Biology, Duke University Medical Center, Durham, North Carolina 27710, USA
    Genes Dev 22:106-20. 2008
  2. ncbi Requirement for glycogen synthase kinase-3beta in cell survival and NF-kappaB activation
    K P Hoeflich
    Ontario Cancer Institute Princess Margaret Hospital, Toronto, Canada
    Nature 406:86-90. 2000
  3. ncbi Functional redundancy of GSK-3alpha and GSK-3beta in Wnt/beta-catenin signaling shown by using an allelic series of embryonic stem cell lines
    Bradley W Doble
    Samuel Lunenfeld Research Institute, Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Toronto, Ontario M5G 1X5, Canada
    Dev Cell 12:957-71. 2007
  4. pmc Role that phosphorylation of GSK3 plays in insulin and Wnt signalling defined by knockin analysis
    Edward J McManus
    MRC Protein Phosphorylation Unit, MSI WTB complex, University of Dundee, Dundee, Scotland
    EMBO J 24:1571-83. 2005
  5. pmc Deficiency in the inhibitory serine-phosphorylation of glycogen synthase kinase-3 increases sensitivity to mood disturbances
    Abigail Polter
    Department of Psychiatry and Behavioral Neurobiology, University of Alabama at Birmingham, Birmingham, AL 35294 0017, USA
    Neuropsychopharmacology 35:1761-74. 2010
  6. pmc Inhibition of glycogen synthase kinase-3 by lithium correlates with reduced tauopathy and degeneration in vivo
    Wendy Noble
    Center for Dementia Research, Nathan S Kline Institute, New York University, 140 Old Orangeburg Road, Orangeburg, NY 10962, USA
    Proc Natl Acad Sci U S A 102:6990-5. 2005
  7. pmc In vivo regulation of glycogen synthase kinase-3beta (GSK3beta) by serotonergic activity in mouse brain
    Xiaohua Li
    Department of Psychiatry and Behavioral Neurobiology, University of Alabama at Birmingham, Birmingham, AL 35294 0017, USA
    Neuropsychopharmacology 29:1426-31. 2004
  8. ncbi N-terminal cleavage of GSK-3 by calpain: a new form of GSK-3 regulation
    Paloma Goñi-Oliver
    Centro de Biologia Molecular Severo Ochoa, Consejo Superior de Investigaciones Cientificas Universidad Autónoma CSIC UAM, Fac Ciencias, Universidad Autonoma de Madrid, Cantoblanco, 28049 Madrid, Spain
    J Biol Chem 282:22406-13. 2007
  9. pmc Toll-like receptor-mediated cytokine production is differentially regulated by glycogen synthase kinase 3
    Michael Martin
    Department of Oral Biology, University of Alabama at Birmingham, Birmingham, Alabama 35294 2170, USA
    Nat Immunol 6:777-84. 2005
  10. pmc Neural precursor cells are protected from apoptosis induced by trophic factor withdrawal or genotoxic stress by inhibitors of glycogen synthase kinase 3
    Tae Yeon Eom
    Department of Psychiatry and Behavioral Neurobiology, University of Alabama at Birmingham, Birmingham, Alabama 35294 0017, USA
    J Biol Chem 282:22856-64. 2007

Research Grants

Detail Information

Publications177 found, 100 shown here

  1. pmc Axin and GSK3- control Smad3 protein stability and modulate TGF- signaling
    Xing Guo
    Department of Pharmacology and Cancer Biology, Duke University Medical Center, Durham, North Carolina 27710, USA
    Genes Dev 22:106-20. 2008
    ..to the concerted action of the scaffolding protein Axin and its associated kinase, glycogen synthase kinase 3-beta (GSK3-beta). Smad3 physically interacts with Axin and GSK3-beta only in the absence of TGF-beta...
  2. ncbi Requirement for glycogen synthase kinase-3beta in cell survival and NF-kappaB activation
    K P Hoeflich
    Ontario Cancer Institute Princess Margaret Hospital, Toronto, Canada
    Nature 406:86-90. 2000
    ..Thus, GSK-3beta facilitates NF-kappaB function...
  3. ncbi Functional redundancy of GSK-3alpha and GSK-3beta in Wnt/beta-catenin signaling shown by using an allelic series of embryonic stem cell lines
    Bradley W Doble
    Samuel Lunenfeld Research Institute, Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Toronto, Ontario M5G 1X5, Canada
    Dev Cell 12:957-71. 2007
    ..The rheostatic regulation of GSK-3 highlights the importance of considering the contributions of both homologs when studying GSK-3 functions in mammalian systems...
  4. pmc Role that phosphorylation of GSK3 plays in insulin and Wnt signalling defined by knockin analysis
    Edward J McManus
    MRC Protein Phosphorylation Unit, MSI WTB complex, University of Dundee, Dundee, Scotland
    EMBO J 24:1571-83. 2005
    ..To define the role that inactivation of GSK3 plays, we generated homozygous knockin mice in which the protein kinase B phosphorylation sites on GSK3alpha (Ser21)..
  5. pmc Deficiency in the inhibitory serine-phosphorylation of glycogen synthase kinase-3 increases sensitivity to mood disturbances
    Abigail Polter
    Department of Psychiatry and Behavioral Neurobiology, University of Alabama at Birmingham, Birmingham, AL 35294 0017, USA
    Neuropsychopharmacology 35:1761-74. 2010
    ..and mood-regulating neuromodulators increase the inhibitory serine-phosphorylation of glycogen synthase kinase-3 (GSK3), we hypothesized that deficient GSK3 serine-phosphorylation may increase vulnerability to mood-related behavioral ..
  6. pmc Inhibition of glycogen synthase kinase-3 by lithium correlates with reduced tauopathy and degeneration in vivo
    Wendy Noble
    Center for Dementia Research, Nathan S Kline Institute, New York University, 140 Old Orangeburg Road, Orangeburg, NY 10962, USA
    Proc Natl Acad Sci U S A 102:6990-5. 2005
    ..These results support the idea that kinases are involved in tauopathy progression and that kinase inhibitors may be effective therapeutically...
  7. pmc In vivo regulation of glycogen synthase kinase-3beta (GSK3beta) by serotonergic activity in mouse brain
    Xiaohua Li
    Department of Psychiatry and Behavioral Neurobiology, University of Alabama at Birmingham, Birmingham, AL 35294 0017, USA
    Neuropsychopharmacology 29:1426-31. 2004
    ..These results raise the possibility that impaired inhibitory control of GSK3beta may occur in conditions where serotonergic activity is dysregulated, such as in mood disorders...
  8. ncbi N-terminal cleavage of GSK-3 by calpain: a new form of GSK-3 regulation
    Paloma Goñi-Oliver
    Centro de Biologia Molecular Severo Ochoa, Consejo Superior de Investigaciones Cientificas Universidad Autónoma CSIC UAM, Fac Ciencias, Universidad Autonoma de Madrid, Cantoblanco, 28049 Madrid, Spain
    J Biol Chem 282:22406-13. 2007
    ..These data provide the first direct evidence that calpain promotes GSK-3 truncation in a way that has implications in signal transduction, and probably in pathological disorders such as Alzheimer disease...
  9. pmc Toll-like receptor-mediated cytokine production is differentially regulated by glycogen synthase kinase 3
    Michael Martin
    Department of Oral Biology, University of Alabama at Birmingham, Birmingham, Alabama 35294 2170, USA
    Nat Immunol 6:777-84. 2005
    ..Here we report that glycogen synthase kinase 3 (GSK3) differentially regulates TLR-mediated production of pro- and anti-inflammatory cytokines...
  10. pmc Neural precursor cells are protected from apoptosis induced by trophic factor withdrawal or genotoxic stress by inhibitors of glycogen synthase kinase 3
    Tae Yeon Eom
    Department of Psychiatry and Behavioral Neurobiology, University of Alabama at Birmingham, Birmingham, Alabama 35294 0017, USA
    J Biol Chem 282:22856-64. 2007
    ..This investigation found that glycogen synthase kinase 3 (GSK3) promotes apoptotic signaling in cultured NPCs derived from embryonic mouse brain subjected to two common apoptotic ..
  11. ncbi Glycogen synthase kinase 3 suppresses myogenic differentiation through negative regulation of NFATc3
    Jos L J Van Der Velden
    Department of Respiratory Medicine, Nutrition and Toxicology Research Institute Maastricht, Maastricht University, 6202 AZ Maastricht, The Netherlands
    J Biol Chem 283:358-66. 2008
    ..Inhibition of GSK-3beta may be a potential strategy in prevention or treatment of muscle atrophy...
  12. ncbi The roles of cyclin-dependent kinase 5 and glycogen synthase kinase 3 in tau hyperphosphorylation
    Florian Plattner
    Wolfson Institute for Biomedical Research, University College London, London WC1E 6BT, United Kingdom
    J Biol Chem 281:25457-65. 2006
    ..of proline-directed kinases, such as cyclin-dependent kinase 5 (Cdk5) and glycogen synthase kinase 3 (GSK3), has been implicated in the aberrant phosphorylation of tau at proline-directed sites...
  13. pmc Glycogen synthase kinase-3 promotes the synergistic action of interferon-gamma on lipopolysaccharide-induced IL-6 production in RAW264.7 cells
    Eleonore Beurel
    Department of Psychiatry and Behavioral Neurobiology, 1720 Seventh Avenue South, University of Alabama at Birmingham, Birmingham, AL 35294 0017, USA
    Cell Signal 21:978-85. 2009
    ..7 cells by IFN-gamma is highly dependent on glycogen synthase kinase-3 (GSK3)...
  14. ncbi Full reversal of Alzheimer's disease-like phenotype in a mouse model with conditional overexpression of glycogen synthase kinase-3
    Tobias Engel
    Centro de Biologia Molecular Severo Ochoa, Consejo Superior de Investigaciones Cientificas, Universidad Autonoma de Madrid, 28049 Madrid, Spain
    J Neurosci 26:5083-90. 2006
    ....
  15. doi GSK-3 is a master regulator of neural progenitor homeostasis
    Woo Yang Kim
    Neuroscience Center, University of North Carolina School of Medicine, Chapel Hill, North Carolina, USA
    Nat Neurosci 12:1390-7. 2009
    ..Our results indicate that GSK-3 signaling is an essential mediator of homeostatic controls that regulate neural progenitors during mammalian brain development...
  16. pmc Differential regulation of STAT family members by glycogen synthase kinase-3
    Eleonore Beurel
    Department of Psychiatry and Behavioral Neurobiology, University of Alabama, Birmingham, Alabama 35294 0017, USA
    J Biol Chem 283:21934-44. 2008
    ..We found that STAT3 activation is highly dependent on glycogen synthase kinase-3 (GSK3)...
  17. pmc Lithium ameliorates altered glycogen synthase kinase-3 and behavior in a mouse model of fragile X syndrome
    Christopher J Yuskaitis
    Department of Psychiatry and Behavioral Neurobiology, 1720 7th Ave South, Sparks Center 1057, University of Alabama at Birmingham, Birmingham, AL 35294 0017, USA
    Biochem Pharmacol 79:632-46. 2010
    ..This study examined the effects on glycogen synthase kinase-3 (GSK3) of treatment with a metabotropic glutamate receptor (mGluR) antagonist, MPEP, and the GSK3 inhibitor, lithium, in ..
  18. pmc GSK3beta promotes apoptosis after renal ischemic injury
    Zhiyong Wang
    Evans Biomedical Research Center, Renal Section, Room 546, 650 Albany Street, Boston, MA 02118 2518, USA
    J Am Soc Nephrol 21:284-94. 2010
    ..Taken together, GSK3beta-mediated Bax activation induces apoptosis and tubular damage that contribute to acute ischemic kidney injury...
  19. pmc Blocked inhibitory serine-phosphorylation of glycogen synthase kinase-3alpha/beta impairs in vivo neural precursor cell proliferation
    Tae Yeon Eom
    Department of Psychiatry, Behavioral Neurobiology, University of Alabama at Birmingham, Birmingham, Alabama 35294 0017, USA
    Biol Psychiatry 66:494-502. 2009
    ..Because these diseases might be associated with inadequately controlled glycogen synthase kinase-3 (GSK3), we tested whether blocked inhibitory serine-phosphorylation of GSK3 impairs neurogenesis.
  20. pmc Selectively silencing GSK-3 isoforms reduces plaques and tangles in mouse models of Alzheimer's disease
    David E Hurtado
    Center for Neurodegenerative Disease Research, Department of Pathology and Laboratory Medicine, and Institute on Aging, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104 4283, USA
    J Neurosci 32:7392-402. 2012
    ..These findings highlight the potential importance of GSK-3α as a possible therapeutic target for ameliorating behavioral impairments linked to AD SPs and NFTs...
  21. pmc Phosphatidylinositol 3-kinase (PI3K) signaling via glycogen synthase kinase-3 (Gsk-3) regulates DNA methylation of imprinted loci
    Anthony P Popkie
    Graduate Program in Molecular, Cellular and Developmental Biology, The Ohio State University, Columbus, Ohio 43210, USA
    J Biol Chem 285:41337-47. 2010
    ..Finally, we find that N-Myc is a potent Gsk-3-dependent regulator of Dnmt3a2 expression. In summary, we have identified a signal transduction pathway that is capable of altering the DNA methylation of imprinted loci...
  22. ncbi Expression of glycogen synthase kinase-3 isoforms in mouse tissues and their transcription in the brain
    Hong bing Yao
    Department of Biochemistry, The Chinese University of Hong Kong, Shatin, N T, Hong Kong, China
    J Chem Neuroanat 23:291-7. 2002
    ..The differential expression of GSK-3alpha and -3beta mRNAs as well as proteins in other tissues indicate that they play different roles in cellular functions and the developmental process...
  23. pmc Glycogen synthase kinase-3 is essential for β-arrestin-2 complex formation and lithium-sensitive behaviors in mice
    W Timothy O'Brien
    Department of Medicine, Hematology Oncology, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, USA
    J Clin Invest 121:3756-62. 2011
    ..GSK-3β (Gsk3b) overexpression reversed behavioral defects observed in lithium-treated mice and similar behaviors observed in ..
  24. pmc GSK3beta is a negative regulator of platelet function and thrombosis
    Dongjun Li
    Center for Translational Medicine, Department of Medicine, Thomas Jefferson University, Philadelphia, PA 19107, USA
    Blood 111:3522-30. 2008
    ..Treatment of human platelets with GSK3 inhibitors renders them more sensitive to agonist-induced aggregation, suggesting that GSK3 suppresses platelet ..
  25. pmc A divergent canonical WNT-signaling pathway regulates microtubule dynamics: dishevelled signals locally to stabilize microtubules
    Lorenza Ciani
    Department of Biological Sciences, Imperial College London, London SW7 2AZ, England, UK
    J Cell Biol 164:243-53. 2004
    ..Our data indicate a bifurcation in the so-called canonical WNT-signaling pathway to regulate microtubule stability...
  26. doi p38 mitogen-activated protein kinase regulates canonical Wnt-beta-catenin signaling by inactivation of GSK3beta
    Rama Kamesh Bikkavilli
    Department of Pharmacology, Health Sciences Center, State University of New York at Stony Brook, Stony Brook, NY 11794 8651, USA
    J Cell Sci 121:3598-607. 2008
    ..We demonstrate the involvement of G-proteins and Dishevelleds in Wnt3a-induced p38 MAPK activation, highlighting a critical role for p38 MAPK in canonical Wnt-beta-catenin signaling...
  27. pmc Phosphorylation by p38 MAPK as an alternative pathway for GSK3beta inactivation
    Tina M Thornton
    Department of Medicine Immunobiology Program, University of Vermont, Burlington, VT 05405 0068, USA
    Science 320:667-70. 2008
    ..Activation of beta-catenin-mediated signaling through GSK3beta inhibition provides a potential mechanism for p38 MAPK-mediated survival in specific tissues...
  28. doi Inhibition of GSK3beta by postconditioning is required to prevent opening of the mitochondrial permeability transition pore during reperfusion
    Ludovic Gomez
    INSERM U886, Universite Claude Bernard Lyon, 69373 Lyon, France
    Circulation 117:2761-8. 2008
    ..We investigated whether phosphorylated GSK3beta may protect the heart via the inhibition of mPTP opening during postconditioning...
  29. ncbi Glycogen synthase kinase-3 beta is highly activated in nuclei and mitochondria
    Gautam N Bijur
    Department of Psychiatry and Behavioral Neurology, University of Alabama at Birmingham, 35294 0017, USA
    Neuroreport 14:2415-9. 2003
    Glycogen synthase kinase-3 beta (GSK3 beta) is located predominantly in the cytosol, but also is in nuclei and mitochondria...
  30. ncbi Inhibitory phosphorylation of glycogen synthase kinase-3 (GSK-3) in response to lithium. Evidence for autoregulation of GSK-3
    Fang Zhang
    Department of Pharmacology, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104 6148, USA
    J Biol Chem 278:33067-77. 2003
    ..Finally, evidence is presented that N-terminal phosphorylation of GSK-3 can be regulated by the GSK-3-dependent protein phosphatase-1.inhibitor-2 complex...
  31. pmc Degradation of Mcl-1 by beta-TrCP mediates glycogen synthase kinase 3-induced tumor suppression and chemosensitization
    Qingqing Ding
    Department of Molecular and Cellular Oncology, The University of Texas M D Anderson Cancer Center, 1515 Holcombe Blvd, Houston, TX 77030, USA
    Mol Cell Biol 27:4006-17. 2007
    ..Our results indicate that the turnover of Mcl-1 by beta-TrCP is an essential mechanism for GSK-3beta-induced apoptosis and contributes to GSK-3beta-mediated tumor suppression and chemosensitization...
  32. pmc The formin mDia regulates GSK3beta through novel PKCs to promote microtubule stabilization but not MTOC reorientation in migrating fibroblasts
    Christina H Eng
    Department of Anatomy and Cell Biology, Columbia University, New York, NY 10032, USA
    Mol Biol Cell 17:5004-16. 2006
    ..Novel PKCs also interacted with mDia in vivo and in vitro. These results identify a new activity for the formin mDia in regulating GSK3beta through novel PKCs and implicate novel PKCs as new factors in the MT stabilization pathway...
  33. pmc Deletion of GSK-3beta in mice leads to hypertrophic cardiomyopathy secondary to cardiomyoblast hyperproliferation
    Risto Kerkela
    Center for Translational Medicine, Thomas Jefferson University, Philadelphia, Pennsylvania, USA
    J Clin Invest 118:3609-18. 2008
    ..We report that terminal cardiomyocyte differentiation was substantially blunted in Gsk3b(-/-) embryoid bodies...
  34. pmc GSK-3beta is required for memory reconsolidation in adult brain
    Tetsuya Kimura
    Lab for Alzheimer s Disease, RIKEN Brain Science Institute, Wako, Saitama, Japan
    PLoS ONE 3:e3540. 2008
    ..Intraperitoneal injection of a GSK-3 inhibitor before memory reactivation impaired memory reconsolidation in WT mice. These results suggest that memory reconsolidation requires activation of GSK-3beta in the adult brain...
  35. doi GSK3β negatively regulates oligodendrocyte differentiation and myelination in vivo
    Kasum Azim
    Institute of Biology and Biomedical Sciences, School of Pharmacy and Biomedical Sciences, University of Portsmouth, Portsmouth, United Kingdom
    Glia 59:540-53. 2011
    Glycogen synthase kinase 3β (GSK3β) is an essential integrating molecule for multiple proliferation and differentiation signals that regulate cell fate...
  36. doi Deletion of glycogen synthase kinase-3β in cartilage results in up-regulation of glycogen synthase kinase-3α protein expression
    J R Gillespie
    Department of Physiology and Pharmacology, University of Western Ontario, London, Ontario, Canada
    Endocrinology 152:1755-66. 2011
    ..However, cartilage-specific deletion of the Gsk3b gene in mice has minimal effects on skeletal growth or development...
  37. pmc GSK3beta mediates renal response to vasopressin by modulating adenylate cyclase activity
    Reena Rao
    Division of Nephrology and Hypertension, Department of Medicine, Vanderbilt University Medical Center, Nashville, Tennessee 37232, USA
    J Am Soc Nephrol 21:428-37. 2010
    ..In summary, GSK3beta inactivation or deletion reduces aquaporin 2 expression by modulating adenylate cyclase activity and cAMP generation, thereby impairing responses to vasopressin in the renal collecting duct...
  38. pmc GSK3 influences social preference and anxiety-related behaviors during social interaction in a mouse model of fragile X syndrome and autism
    Marjelo A Mines
    Department of Psychiatry and Behavioral Neurobiology, University of Alabama at Birmingham, Birmingham, Alabama, United States of America
    PLoS ONE 5:e9706. 2010
    ..Glycogen synthase kinase-3 (GSK3) is hyperactive in brains of Fmr1 knockout mice, and inhibition of GSK3 by lithium administration ameliorates some ..
  39. doi Conditional ablation of glycogen synthase kinase 3β in postnatal mouse kidney
    Yan Ge
    Department of Medicine, Brown University School of Medicine, Providence, Rhode Island 02903, USA
    Lab Invest 91:85-96. 2011
    Glycogen synthase kinase (GSK)3 is a ubiquitously expressed serine/threonine kinase existing in two isoforms, namely GSK3α and GSK3β...
  40. ncbi GSK-3beta acts downstream of PP2A and the PI 3-kinase-Akt pathway, and upstream of caspase-2 in ceramide-induced mitochondrial apoptosis
    Chiou Feng Lin
    Department of Microbiology and Immunology, National Cheng Kung University Medical College, Tainan 701, Taiwan
    J Cell Sci 120:2935-43. 2007
    ..These results indicate a role for GSK-3beta in ceramide-induced apoptosis, in which GSK-3beta acts downstream of PP2A and the PI 3-kinase-Akt pathway, and upstream of caspase-2 and caspase-8...
  41. ncbi Inhibition of glycogen synthase kinase 3 beta is involved in the resistance to oxidative stress in neuronal HT22 cells
    Monika Schäfer
    Independent Research Group Neurodegeneration, Max Planck Institute for Psychiatry, Munich, Germany
    Brain Res 1005:84-9. 2004
    ....
  42. ncbi Novel anti-inflammatory role for glycogen synthase kinase-3beta in the inhibition of tumor necrosis factor-alpha- and interleukin-1beta-induced inflammatory gene expression
    Angela Vines
    Reddy US Therapeutics, Dr Reddy s Laboratories, Norcross, Georgia 30071, USA
    J Biol Chem 281:16985-90. 2006
    ..We conclude that GSK-3beta selectively regulates NFkappaB-mediated inflammatory gene expression by controlling the flow of NFkappaB activity between transcription of inflammatory and survival genes...
  43. pmc Glycogen synthase kinase-3 is an early determinant in the differentiation of pathogenic Th17 cells
    Eleonore Beurel
    Department of Psychiatry and Behavioral Neurobiology, University of Alabama at Birmingham, Birmingham, AL 35294, USA
    J Immunol 186:1391-8. 2011
    ..During polarization of CD4(+) T cells to Th17 cells, we found that inhibition of glycogen synthase kinase-3 (GSK3) blocked IL-6 production, STAT3 activation, and polarization to Th17 cells...
  44. pmc Glycogen synthase kinase-3β inactivation inhibits tumor necrosis factor-α production in microglia by modulating nuclear factor κB and MLK3/JNK signaling cascades
    Mei Jen Wang
    Department of Medical Research, Neuro Medical Scientific Center, Buddhist Tzu Chi General Hospital, Hualien, Taiwan
    J Neuroinflammation 7:99. 2010
    ..Tumor necrosis factor-α (TNF-α) plays a central role in injury caused by neuroinflammation. We investigated the regulatory effect of GSK-3β on TNF-α production by microglia to discern the molecular mechanisms of this modulation...
  45. ncbi Hedgehog and PI-3 kinase signaling converge on Nmyc1 to promote cell cycle progression in cerebellar neuronal precursors
    Anna Marie Kenney
    Department of Pediatric Oncology, Dana Farber Cancer Institute and Harvard Medical School, Boston, MA 02115, USA
    Development 131:217-28. 2004
    ..The PI3K pathway stabilizes Nmyc1 protein via inhibition of GSK3-dependent Nmyc1 phosphorylation and degradation...
  46. pmc β-catenin enhances Oct-4 activity and reinforces pluripotency through a TCF-independent mechanism
    Kevin F Kelly
    Stem Cell and Cancer Research Institute, McMaster University, Hamilton, Ontario, Canada
    Cell Stem Cell 8:214-27. 2011
    ..Collectively, our data suggest previously underappreciated, divergent TCF-dependent and TCF-independent roles for β-catenin in ESCs...
  47. ncbi Overactivation of glycogen synthase kinase-3 by inhibition of phosphoinositol-3 kinase and protein kinase C leads to hyperphosphorylation of tau and impairment of spatial memory
    Shi Jie Liu
    Pathophysiology Department, Neuroscience Institute, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China
    J Neurochem 87:1333-44. 2003
    ....
  48. pmc Glycogen synthase kinase 3 activity during development of bone marrow-derived dendritic cells (DCs) essential for the DC function to induce T helper 2 polarization
    Takenori Ono
    Division of Immunobiology, Institute for Genetic Medicine, Hokkaido University, Sapporo, Japan
    Immunology 122:189-98. 2007
    ..We examined the role of glycogen synthase kinase 3 (GSK3) activity during DC development from murine bone marrow (BM) cells...
  49. pmc Protein kinase G-dependent cardioprotective mechanism of phosphodiesterase-5 inhibition involves phosphorylation of ERK and GSK3beta
    Anindita Das
    Division of Cardiology, Department of Internal Medicine, Virginia Commonwealth University, Richmond, Virginia 23298, USA
    J Biol Chem 283:29572-85. 2008
    ..Moreover, our results demonstrate that sildenafil activates a PKG-dependent novel signaling cascade that involves activation of ERK and inhibition of glycogen synthase kinase 3beta leading to cytoprotection...
  50. pmc Genetic deficiency of glycogen synthase kinase-3beta corrects diabetes in mouse models of insulin resistance
    Katsuya Tanabe
    Division of Endocrinology, Metabolism, and Lipid Research, Washington University School of Medicine, St Louis, Missouri, United States of America
    PLoS Biol 6:e37. 2008
    ..These results thus form the rationale for developing agents to inhibit this enzyme in obese insulin-resistant individuals to preserve beta-cells and prevent diabetes onset...
  51. pmc Wnt regulates axon behavior through changes in microtubule growth directionality: a new role for adenomatous polyposis coli
    Silvia A Purro
    Research Department of Cell and Developmental Biology, University College London, London WC1E 6BT, United Kingdom
    J Neurosci 28:8644-54. 2008
    ..Consistently, short hairpin RNA knockdown of APC mimics Wnt3a function. Together, our findings define APC as a key Wnt signaling target in the regulation of microtubule growth direction...
  52. ncbi Genetic deletion of glycogen synthase kinase-3beta abrogates activation of IkappaBalpha kinase, JNK, Akt, and p44/p42 MAPK but potentiates apoptosis induced by tumor necrosis factor
    Yasunari Takada
    Cytokine Research Laboratory, Department of Bioimmunotherapy, University of Texas M D Anderson Cancer Center, Houston, Texas 77030, USA
    J Biol Chem 279:39541-54. 2004
    ....
  53. doi Interplay between cyclin-dependent kinase 5 and glycogen synthase kinase 3 beta mediated by neuregulin signaling leads to differential effects on tau phosphorylation and amyloid precursor protein processing
    Yi Wen
    Taub Institute at Columbia University Medical Center, New York State Psychiatric Institute, New York, New York 10032, USA
    J Neurosci 28:2624-32. 2008
    ..Thus, cdk5 inhibitors may not be effective in targeting tau phosphorylation in the elderly...
  54. ncbi Glycogen synthase kinase 3beta is a negative regulator of growth factor-induced activation of the c-Jun N-terminal kinase
    Shuying Liu
    Department of Molecular Therapeutics, University of Texas M D Anderson Cancer Center, Houston, Texas 77030, USA
    J Biol Chem 279:51075-81. 2004
    ..These results reveal a novel role for GSK-3beta in signal transduction and cellular responses to growth factors...
  55. doi Differential regulation of AKT, MAPK and GSK3β during C2-ceramide-induced neuronal death
    Gonzalo Arboleda
    Grupo de Neurociencias, Facultad de Medicina, Universidad Nacional de Colombia, Bogota, Colombia
    Neurotoxicology 31:687-93. 2010
    ..In the present paper we have analysed the contribution of PI3K/AKT-GSK3β and MAPK (ERK and JNK) pathways to cell death in a catecholaminergic cell line following exposure to C(2)-..
  56. pmc Pharmaceutical modulation of canonical Wnt signaling in multipotent stromal cells for improved osteoinductive therapy
    Ulf Krause
    Institute for Regenerative Medicine at Scott and White Hospital, Texas A and M Health Science Center, Temple, TX 76502, USA
    Proc Natl Acad Sci U S A 107:4147-52. 2010
    ....
  57. doi Phosphatidylinositol-3-kinase-atypical protein kinase C signaling is required for Wnt attraction and anterior-posterior axon guidance
    Alex M Wolf
    Committee on Developmental Biology, The University of Chicago, Chicago, Illinois 60637, USA
    J Neurosci 28:3456-67. 2008
    ..Therefore, we propose that atypical PKC signaling is required for Wnt-mediated A-P axon guidance and that PI3K can act as a switch to activate Wnt responsiveness during midline crossing...
  58. pmc Tissue-specific analysis of glycogen synthase kinase-3α (GSK-3α) in glucose metabolism: effect of strain variation
    Satish Patel
    Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Toronto, Ontario, Canada
    PLoS ONE 6:e15845. 2011
    ..We also found that muscle (but not liver) inactivation of GSK-3β conferred insulin and glucose sensitization in an in-bred strain of mice (C57BL/6)...
  59. pmc Dual regulation of glycogen synthase kinase 3 (GSK3)α/β by protein kinase C (PKC)α and Akt promotes thrombin-mediated integrin αIIbβ3 activation and granule secretion in platelets
    Samantha F Moore
    School of Physiology and Pharmacology, School of Medical Sciences, University of Bristol, Bristol BS8 1TD, United Kingdom
    J Biol Chem 288:3918-28. 2013
    ..kinase, tonically active in resting cells but inhibited by phosphorylation of an N-terminal Ser residue (Ser(21) in GSK3α and Ser(9) in GSK3β) in response to varied external stimuli...
  60. ncbi Glycogen synthase kinase-3beta suppresses tumor necrosis factor-alpha expression in cardiomyocytes during lipopolysaccharide stimulation
    E Shen
    Center for Critical Illness Research, Lawson Health Research Institute, London Health Sciences Center, London, Ontario, Canada
    J Cell Biochem 104:329-38. 2008
    ..Our study demonstrates that GSK-3beta plays an inhibitory role in cardiomyocyte TNF-alpha expression during LPS stimulation, and it may be a potential therapeutic target for sepsis...
  61. ncbi Mechanism of phosphorylation-dependent binding of APC to beta-catenin and its role in beta-catenin degradation
    Nam Chul Ha
    Department of Structural Biology, Stanford University School of Medicine, Stanford, CA 94043, USA
    Mol Cell 15:511-21. 2004
    ..Phosphorylated APC and axin bind to the same surface of, and compete directly for, beta-catenin. The structural and biochemical data suggest a novel model for how APC functions in beta-catenin degradation...
  62. pmc Role of GSK-3β in the osteogenic differentiation of palatal mesenchyme
    Emily R Nelson
    Hagey Laboratory for Pediatric Regenerative Medicine, Plastic and Reconstructive Surgery Division, Department of Surgery, Stanford University School of Medicine, Stanford, California, United States of America
    PLoS ONE 6:e25847. 2011
    ..Using GSK-3ß null mouse embryos, we examine the potential coordinate roles of Wnt and Hedgehog signaling on palatal ossification...
  63. pmc Inactivation of glycogen synthase kinase-3β is required for osteoclast differentiation
    Hyun Duk Jang
    Division of Life and Pharmaceutical Sciences, Center for Cell Signaling and Drug Discovery Research, Ewha Womans University, Seoul 120 750, Korea
    J Biol Chem 286:39043-50. 2011
    ..of GSK-3β activity in bone marrow macrophages by retroviral expression of the constitutively active GSK-3β (GSK3β-S9A) mutant inhibits RANKL-induced osteoclastogenesis, whereas expression of the catalytically inactive GSK-3β (..
  64. pmc Decreased nuclear beta-catenin, tau hyperphosphorylation and neurodegeneration in GSK-3beta conditional transgenic mice
    J J Lucas
    Centro de Biologia Molecular Severo Ochoa, CSIC Universidad Autonoma de Madrid, Departamento de Morfologia, Facultad de Medicina, Universidad Autonoma de Madrid, 28049 Madrid, Spain
    EMBO J 20:27-39. 2001
    ....
  65. pmc Gsk3β is required in the epithelium for palatal elevation in mice
    Fenglei He
    Department of Cell and Molecular Biology, Tulane University, New Orleans, Louisiana 70118, USA
    Dev Dyn 239:3235-46. 2010
    In Wnt/β-catenin signaling pathway, Gsk3β functions to facilitate β-catenin degradation. Inactivation of Gsk3β in mice causes a cleft palate formation, suggesting an involvement of Wnt/β-catenin signaling during palatogenesis...
  66. doi Inhibition of glycogen synthase kinase 3 beta attenuates neurocognitive dysfunction resulting from cranial irradiation
    Dinesh K Thotala
    Department of Radiation Oncology, Vanderbilt University School of Medicine, Nashville, Tennessee 37232 5671, USA
    Cancer Res 68:5859-68. 2008
    ....
  67. doi Functional interference between glycogen synthase kinase-3 beta and the transcription factor Nrf2 in protection against kainate-induced hippocampal cell death
    Ana I Rojo
    Instituto de Investigaciones Biomédicas Alberto Sols UAM CSIC, Departamento de Bioquimica, and Centro de Investigación Biomédica en Red en Enfermedades Neurodegenerativas CIBERNED, Facultad de Medicina, Universidad Autonoma de Madrid, Madrid, Spain
    Mol Cell Neurosci 39:125-32. 2008
    ..Our findings identify the axis GSK-3beta/Nrf2 as a pharmacological target in prevention of excitotoxic neuronal death...
  68. pmc Neuronal pentraxin 1 induction in hypoxic-ischemic neuronal death is regulated via a glycogen synthase kinase-3α/β dependent mechanism
    Juliet C Russell
    The Hugo W Moser Research Institute at Kennedy Krieger, Baltimore, MD 21205, USA
    Cell Signal 23:673-82. 2011
    ..Our findings clearly implicate both GSK-3α- and GSK-3β-dependent mechanism of NP1 induction and point to a novel mechanism in the regulation of hypoxic-ischemic neuronal death...
  69. doi GSK-3β at the crossroads in the signalling of heart preconditioning: implication of mTOR and Wnt pathways
    François Vigneron
    Inserm Unit 828, Pessac, France
    Cardiovasc Res 90:49-56. 2011
    ..Here, we investigate whether the mTOR pathway is involved in cardioprotection...
  70. pmc SCF/{beta}-TrCP promotes glycogen synthase kinase 3-dependent degradation of the Nrf2 transcription factor in a Keap1-independent manner
    Patricia Rada
    Instituto de Investigaciones Biomédicas Alberto Sols UAM CSIC, c Arturo Duperier 4, 28029 Madrid, Spain
    Mol Cell Biol 31:1121-33. 2011
    ..Our results show for the first time that Nrf2 is targeted by GSK-3 for SCF/β-TrCP-dependent degradation. We propose a "dual degradation" model to describe the regulation of Nrf2 under different pathophysiological conditions...
  71. pmc Age-dependent accumulation of soluble amyloid beta (Abeta) oligomers reverses the neuroprotective effect of soluble amyloid precursor protein-alpha (sAPP(alpha)) by modulating phosphatidylinositol 3-kinase (PI3K)/Akt-GSK-3beta pathway in Alzheimer mouse m
    Sebastian Jimenez
    Departamento Bioquimica y Biologia Molecular, Facultad de Farmacia, Universidad de Sevilla, 41012 Sevilla, Spain
    J Biol Chem 286:18414-25. 2011
    ..sAPPα stimulated and Aβ oligomers blocked the prosurvival signaling. Our data might provide insights into the selective vulnerability of specific neuronal groups in Alzheimer disease...
  72. doi Relationship of adult neurogenesis with tau phosphorylation and GSK-3β activity in subventricular zone
    Xiao ping Hong
    Department of Pathophysiology, Key Laboratory of Neurological Diseases of Education Committee of China, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, People s Republic of China
    Neurochem Res 36:288-96. 2011
    ..The SVZ neurogenesis was also unaffected in tau knockout and human tau transgenic mice. These results suggest that tau phosphorylation and GSK-3 activation may not be essential for adult SVZ neurogenesis...
  73. doi Glycogen synthase kinase 3-β: a master regulator of toll-like receptor-mediated chronic intestinal inflammation
    Claudia Hofmann
    Department of Internal Medicine I, Regensburg University Medical Center, Germany
    Inflamm Bowel Dis 16:1850-8. 2010
    ..Glycogen synthase kinase 3-β (GSK3-β) was recently identified as an important regulator of TLR signaling mediating excessive inflammatory responses...
  74. pmc β-arrestin 2 regulates Toll-like receptor 4-mediated apoptotic signalling through glycogen synthase kinase-3β
    Hui Li
    Department of Neurology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China
    Immunology 130:556-63. 2010
    ....
  75. pmc Pivotal role for glycogen synthase kinase-3 in hematopoietic stem cell homeostasis in mice
    Jian Huang
    Department of Medicine Hematology Oncology, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, USA
    J Clin Invest 119:3519-29. 2009
    ..Using loss-of-function approaches in mice, we found that glycogen synthase kinase-3 (Gsk3) plays a pivotal role in controlling the decision between self renewal and differentiation of HSCs...
  76. pmc GSK-3 phosphorylates delta-catenin and negatively regulates its stability via ubiquitination/proteosome-mediated proteolysis
    Minsoo Oh
    College of Pharmacy and Research Institute of Drug Development, Chonnam National University, Gwangju 500 757, Korea
    J Biol Chem 284:28579-89. 2009
    ..These results suggest that GSK-3 interacts with and phosphorylates delta-catenin and thereby negatively affects its stability by enabling its ubiquitination/proteosome-mediated proteolysis...
  77. doi Glycogen synthase kinase-3beta regulates etoposide-induced apoptosis via Bcl-2 mediated caspase-3 activation in C3H10T1/2 cells
    Sun Il Yun
    Department of Endocrinology and Metabolism, Ajou University School of Medicine, San 5 Wonchon Dong Yeongtong Gu, Suwon City, Gyeonggi, 443 721, South Korea
    Apoptosis 14:771-7. 2009
    ..In conclusion, etoposide-induced apoptosis in C3H10T1/2 cells is mediated by GSK3beta, which leads to caspase-3 activation via decrease in Bcl-2 expression...
  78. pmc Regulate axon branching by the cyclic GMP pathway via inhibition of glycogen synthase kinase 3 in dorsal root ganglion sensory neurons
    Zhen Zhao
    Zilkha Neurogenetic Institute, Department of Cell and Neurobiology, Keck School of Medicine, University of Southern California, Los Angeles, California 90089, USA
    J Neurosci 29:1350-60. 2009
    ..In addition, cGMP activation in DRG neurons leads to phosphorylation of glycogen synthase kinase 3 (GSK3), a protein that normally suppresses branching...
  79. pmc Unique and overlapping functions of GSK-3 isoforms in cell differentiation and proliferation and cardiovascular development
    Thomas Force
    Center for Translational Medicine, Cardiology Division, and Program in Cell and Developmental Biology, Thomas Jefferson University, Philadelphia, Pennsylvania 19107, USA
    J Biol Chem 284:9643-7. 2009
    ....
  80. pmc Co-localization of glycogen synthase kinase-3 with neurofibrillary tangles and granulovacuolar degeneration in transgenic mice
    Takashi Ishizawa
    Department of Neuroscience, Mayo Clinic Jacksonville, Jacksonville, FL 32225, USA
    Am J Pathol 163:1057-67. 2003
    ..GKS3) to determine whether the development of tauopathy is associated with activation or increased expression of GSK3, and when the observed changes occur with respect to neurofibrillary tangle (NFT) formation...
  81. doi Kainic acid-induced seizures activate GSK-3β in the hippocampus of D2R-/- mice
    Prem P Tripathi
    CNR Neuroscience Institute
    Neuroreport 21:846-50. 2010
    ..Our results suggest that GSK-3beta activation participates, independently of Akt, in the KA-induced apoptosis in the D2R-/- hippocampus...
  82. pmc Suppressive regulatory T cell activity is potentiated by glycogen synthase kinase 3{beta} inhibition
    Jay A Graham
    Transplantation Unit, Massachusetts General Hospital, Department of Surgery, Harvard Medical School, Boston, Massachusetts 02114, USA
    J Biol Chem 285:32852-9. 2010
    ..Our data suggest that GSK-3β could be a useful target in developing strategies designed to increase the stability and function of Treg cells for inducing allotransplant tolerance or treating autoimmune conditions...
  83. doi IFN-gamma synergizes with LPS to induce nitric oxide biosynthesis through glycogen synthase kinase-3-inhibited IL-10
    Chiou Feng Lin
    Institute of Clinical Medicine, National Cheng Kung University Medical College, Tainan, Taiwan
    J Cell Biochem 105:746-55. 2008
    ..Taken together, these findings reveal the involvement of GSK-3-inhibited IL-10 on the induction of iNOS/NO biosynthesis by IFN-gamma synergized with LPS...
  84. pmc Glycogen synthase kinase 3-dependent phosphorylation of Mdm2 regulates p53 abundance
    Roman Kulikov
    Institut fur Genetik, Forschungszentrum Karlsruhe, Germany
    Mol Cell Biol 25:7170-80. 2005
    ..We therefore conclude that inhibition of GSK-3 contributes to hypophosphorylation of Mdm2 in response to ionizing rays, and in consequence to p53 stabilization...
  85. ncbi Functional interaction of an axin homolog, conductin, with beta-catenin, APC, and GSK3beta
    J Behrens
    Max Delbruck Center for Molecular Medicine, Robert Rossle Strasse 10, 13122 Berlin, Germany
    Science 280:596-9. 1998
    ..Thus, conductin is a component of the multiprotein complex that directs beta-catenin to degradation and is located downstream of APC. In Xenopus embryos, conductin interfered with wnt-induced axis formation...
  86. doi Genetic and pharmacological evidence for schizophrenia-related Disc1 interaction with GSK-3
    Tatiana V Lipina
    Samuel Lunenfeld Research Institute at Mount Sinai Hospital, Toronto, Ontario, M5G 1X5, Canada
    Synapse 65:234-48. 2011
    ....
  87. pmc Tissue-specific role of glycogen synthase kinase 3beta in glucose homeostasis and insulin action
    Satish Patel
    Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Toronto, Ontario, Canada
    Mol Cell Biol 28:6314-28. 2008
    ..These data indicate that there are not only distinct roles for GSK-3alpha and GSK-3beta within the adult but also tissue-specific phenotypes associated with each of these isoforms...
  88. pmc Glycogen synthase kinase-3beta (GSK3beta) inhibition suppresses the inflammatory response to Francisella infection and protects against tularemia in mice
    Ping Zhang
    Department of Pediatric Dentistry, University of Alabama at Birmingham, Birmingham, AL 35294, United States
    Mol Immunol 46:677-87. 2009
    ..tularensis LVS infection, and suggest that inhibition of GSK3beta may represent a novel therapeutic approach in the treatment of tularemia...
  89. ncbi Role of the PDK1-PKB-GSK3 pathway in regulating glycogen synthase and glucose uptake in the heart
    Alfonso Mora
    MRC Protein Phosphorylation Unit, School of Life Sciences, MSI WTB complex, University of Dundee, Dow Street, Dundee DD1 5EH, Scotland
    FEBS Lett 579:3632-8. 2005
    In order to investigate the importance of the PDK1-PKB-GSK3 signalling network in regulating glycogen synthase (GS) in the heart, we have employed tissue specific conditional knockout mice lacking PDK1 in muscle (mPDK1-/-), as well as ..
  90. pmc Subcellular localization of glycogen synthase kinase 3beta controls embryonic stem cell self-renewal
    Matthew Bechard
    Paul D Coverdell Center for Biomedical and Health Sciences, Athens, Georgia 30602, USA
    Mol Cell Biol 29:2092-104. 2009
    ..This novel mechanism explains how AKT1 promotes self-renewal by regulating the activity and localization of GSK3beta. This pathway converges on c-myc, a key regulator of mESC self-renewal...
  91. pmc Role of GSK3 beta in behavioral abnormalities induced by serotonin deficiency
    Jean Martin Beaulieu
    Department of Cell Biology, Mouse Behavioral and Neuroendocrine Analyses Core Facility, Duke University Medical Center, Durham, NC 27710, USA
    Proc Natl Acad Sci U S A 105:1333-8. 2008
    ..Targeting GSK3beta and related signaling events may afford therapeutic advantages for the management of certain 5-HT-related psychiatric conditions...
  92. pmc Glycogen synthase kinase 3beta-mediated apoptosis of primary cortical astrocytes involves inhibition of nuclear factor kappaB signaling
    Joseph F Sanchez
    Program in Genetics, Department of Biochemistry and Biophysics, University of Rochester School of Medicine and Dentistry, Rochester, New York, USA
    Mol Cell Biol 23:4649-62. 2003
    ..These findings therefore implicate GSK-3beta as a regulator of NF-kappaB activation in astrocytes and suggest that the pro-apoptotic effects of GSK-3beta may be mediated at least in part through the inhibition of NF-kappaB pathway...
  93. pmc Involvment of cytosolic and mitochondrial GSK-3beta in mitochondrial dysfunction and neuronal cell death of MPTP/MPP-treated neurons
    Agnès Petit-Paitel
    Institut de Pharmacologie Moleculaire et Cellulaire, Centre National de la Recherche Scientifique, Unité Mixte de Recherche 6097, Valbonne, France
    PLoS ONE 4:e5491. 2009
    ..Inhibition of GSK-3beta activity might provide protection against mitochondrial stress-induced cell death...
  94. pmc In vivo regulation of GSK3 phosphorylation by cholinergic and NMDA receptors
    Patrizia De Sarno
    Department of Psychiatry and Behavioral Neurobiology, 1720 Seventh Ave South, Sparks Center 1057, University of Alabama at Birmingham, Birmingham, AL 35294 0017, USA
    Neurobiol Aging 27:413-22. 2006
    Glycogen synthase kinase-3 (GSK3), which is inhibited by serine-phosphorylation, is involved in the neuropathology of Alzheimer's disease (AD)...
  95. pmc Glycogen synthase kinase 3beta functions to specify gene-specific, NF-kappaB-dependent transcription
    Kris A Steinbrecher
    Lineberger Comprehensive Cancer Center, University of North Carolina School of Medicine, Chapel Hill, NC 27599 7295, USA
    Mol Cell Biol 25:8444-55. 2005
    ..Therefore, GSK-3beta has profound effects on transcription in a gene-specific manner through a mechanism involving control of promoter-specific recruitment of NF-kappaB...
  96. ncbi Glycogen synthase kinase 3 beta is a natural activator of mitogen-activated protein kinase/extracellular signal-regulated kinase kinase kinase 1 (MEKK1)
    Jin Woo Kim
    National Creative Research Initiative Center for Cell Death, Graduate School of Life Science and Biotechnology, Korea University, Seoul 136 701, Korea
    J Biol Chem 278:13995-4001. 2003
    Glycogen synthase kinase 3beta (GSK3 beta) is implicated in many biological events, including embryonic development, cell differentiation, apoptosis, and insulin response...
  97. doi An alternatively spliced form of glycogen synthase kinase-3beta is targeted to growing neurites and growth cones
    Alison Wood-Kaczmar
    The MRC Centre for Developmental Neurobiology, New Hunts House, Guy s Campus, King s College London, London SE1 1UL, UK
    Mol Cell Neurosci 42:184-94. 2009
    ..We conclude that the alternatively spliced isoform of GSK-3beta, GSK-3beta2, is neuron-specific and has overlapping activities with GSK-3beta1...
  98. ncbi Transgenic mice overexpressing glycogen synthase kinase 3beta: a putative model of hyperactivity and mania
    Jos Prickaerts
    Division of Psychiatry, Johnson and Johnson Pharmaceutical Research and Development, B 2340 Beerse, Belgium
    J Neurosci 26:9022-9. 2006
    ..The behavioral observations led to the suggestion that the model at hand recapitulates hyperactivity as observed in the manic phase of bipolar disorder...
  99. ncbi A role for glycogen synthase kinase-3beta in the mammalian circadian clock
    Chisato Iitaka
    Clock Cell Biology Research Group, Institute for Biological Resource and Function, National Institute of Advanced Industrial Science and Technology, Higashi, Tsukuba, Ibaraki, Japan
    J Biol Chem 280:29397-402. 2005
    ..Recombinant GSK-3beta can phosphorylate PER2 in vitro. GSK-3beta promotes the nuclear translocation of PER2 in COS1 cells. The present data suggest that GSK-3beta plays important roles in mammalian circadian clock...
  100. ncbi Essential roles for GSK-3s and GSK-3-primed substrates in neurotrophin-induced and hippocampal axon growth
    Woo Yang Kim
    UNC Neuroscience Center, University of North Carolina, Chapel Hill, North Carolina 27599, USA
    Neuron 52:981-96. 2006
    ..Our results suggest that GSK-3 is a downstream convergent point for many axon growth regulatory pathways and that differential regulation of primed versus all GSK-3 substrates is associated with a specific morphological outcome...
  101. ncbi Glycogen synthase kinase-3 is an in vivo regulator of hematopoietic stem cell repopulation
    Jennifer J Trowbridge
    Krembil Centre for Stem Cell Biology, Robarts Research Institute, 100 Perth Drive, London, Ontario, Canada, N6A 5K8
    Nat Med 12:89-98. 2006
    ..Our study establishes GSK-3 as a specific in vivo modulator of HSC activity, and suggests that administration of GSK-3 inhibitors may provide a clinical means to directly enhance the repopulating capacity of transplanted HSCs...

Research Grants50

  1. ALTERED MECHANICAL LOADS AND SKELETAL MUSCLE PHENOTYPE
    Richard Tsika; Fiscal Year: 2004
    ..abstract_text> ..
  2. EXERCISE HYPERTROPHY AND CONTROL OF MYOSIN INDUCTION
    Richard Tsika; Fiscal Year: 2007
    ..abstract_text> ..
  3. EXERCISE HYPERTROPHY AND CONTROL OF MYOSIN INDUCTION
    Richard Tsika; Fiscal Year: 2001
    ..These experiments are expected to identify potential protein/DNA targets for therapies aimed at providing countermeasures to derangements in muscle phenotypes and growth patterns attributable to muscle diseases. ..
  4. ALTERED MECHANICAL LOADS AND SKELETAL MUSCLE PHENOTYPE
    Richard Tsika; Fiscal Year: 2009
    ..abstract_text> ..
  5. Cytosolic Phospholipase A2 in Cardiac Hypertrophy
    Thomas Force; Fiscal Year: 2005
    ..abstract_text> ..
  6. Glucogen Synthase Kinase 3beta and Bipolar Disorder
    Xiaohua Li; Fiscal Year: 2007
    ....
  7. GSK3: Neural Modulators and Mood Disorders
    Xiaohua Li; Fiscal Year: 2007
    ..Based on the accumulating evidence showing that glycogen synthase kinase-3 (GSK3) is an active and highly regulated protein kinase in neural tissues, GSK3 is an intracellular target of ..
  8. SIGNALING MECHANISMS GOVERNING CARDIAC HYPERTROPHY
    Thomas Force; Fiscal Year: 2010
    ..We believe the studies outlined herein could identify novel targets, inhibition of which could retard or reverse the process of hypertrophy, a major risk factor for heart failure, stroke, and myocardial infarction. ..
  9. SIGNALING MECHANISMS GOVERNING CARDIAC HYPERTROPHY
    Thomas Force; Fiscal Year: 2007
    ..We believe the studies outlined herein could identify novel targets, inhibition of which could retard or reverse the process of hypertrophy, a major risk factor for heart failure, stroke, and myocardial infarction. ..
  10. GMF in CNS inflammation
    Asgar Zaheer; Fiscal Year: 2010
    ..These studies may provide the scientific rationale for the development of a novel non-toxic therapy for MS. ..
  11. Glia Maturation Factor in CNS Inflammation
    Asgar Zaheer; Fiscal Year: 2007
    ..Knowledge obtained from this study can also be applied to degenerative diseases of the brain where microglial activation plays an important role, such as Alzheimer's and Parkinson's. ..
  12. GSK3: Neural Modulators and Mood Disorders
    Xiaohua Li; Fiscal Year: 2009
    ..Based on the accumulating evidence showing that glycogen synthase kinase-3 (GSK3) is an active and highly regulated protein kinase in neural tissues, GSK3 is an intracellular target of ..
  13. beta-Catenin/NF-kappaBeta and Colon Cancer
    Shahid Umar; Fiscal Year: 2004
    ..By studying a mechanistic basis of NF-kappaB and beta-catenin mediated increases in cell census, in the absence and presence of chronic inflammation, we may identify new treatment strategies for reducing cancer risk. ..
  14. SIGNALING MECHANISMS GOVERNING CARDIAC HYPERTROPHY
    Thomas Force; Fiscal Year: 2006
    ..abstract_text> ..
  15. SIGNALING MECHANISMS GOVERNING CARDIAC HYPERTROPHY
    Thomas Force; Fiscal Year: 2002
    ..These studies will provide for better understanding of the pathways regulating hypertrophy in vivo, and to identify those pathways which could be targets for novel therapeutic strategies to prevent cardiac hypertrophy in patients. ..
  16. C/EBPB And Mitotic Clonal Expansion During Adipogenesis
    Qi Qun Tang; Fiscal Year: 2004
    ..identify the kinase(s) that catalyzes this/these phosphorylation/s and to determine how the kinase(s) is regulated. -determine the role of C/EBP-beta in mitotic clonal expansion and how phosphorylation of C/EBP-beta affects this role...
  17. Research Echocardiography System
    Thomas Force; Fiscal Year: 2004
    ....
  18. Regulation of GSK3beta by Mood Stabilizers
    Xiaohua Li; Fiscal Year: 2005
    ..The data obtained from this proposal will be used to support a future R01 grant application to achieve our long-term goal of understanding the pathophysiology and improving the treatment of bipolar disorder. ..