Gsk3a

Summary

Gene Symbol: Gsk3a
Description: glycogen synthase kinase 3 alpha
Alias: 2700086H06Rik, glycogen synthase kinase-3 alpha, GSK-3 alpha, serine/threonine-protein kinase GSK3A
Species: mouse

Top Publications

  1. pmc Role that phosphorylation of GSK3 plays in insulin and Wnt signalling defined by knockin analysis
    Edward J McManus
    MRC Protein Phosphorylation Unit, MSI WTB complex, University of Dundee, Dundee, Scotland
    EMBO J 24:1571-83. 2005
  2. ncbi Role of the PDK1-PKB-GSK3 pathway in regulating glycogen synthase and glucose uptake in the heart
    Alfonso Mora
    MRC Protein Phosphorylation Unit, School of Life Sciences, MSI WTB complex, University of Dundee, Dow Street, Dundee DD1 5EH, Scotland
    FEBS Lett 579:3632-8. 2005
  3. pmc Essential roles for GSK-3s and GSK-3-primed substrates in neurotrophin-induced and hippocampal axon growth
    Woo Yang Kim
    UNC Neuroscience Center, University of North Carolina, Chapel Hill, North Carolina 27599, USA
    Neuron 52:981-96. 2006
  4. pmc Functional redundancy of GSK-3alpha and GSK-3beta in Wnt/beta-catenin signaling shown by using an allelic series of embryonic stem cell lines
    Bradley W Doble
    Samuel Lunenfeld Research Institute, Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Toronto, Ontario M5G 1X5, Canada
    Dev Cell 12:957-71. 2007
  5. ncbi Glycogen synthase kinase-3alpha reduces cardiac growth and pressure overload-induced cardiac hypertrophy by inhibition of extracellular signal-regulated kinases
    Peiyong Zhai
    Cardiovascular Research Institute, Department of Cell Biology and Molecular Medicine, University of Medicine and Dentistry of New Jersey, New Jersey Medical School, 185 South Orange Avenue, Newark, NJ 07103, USA
    J Biol Chem 282:33181-91. 2007
  6. ncbi Glycogen synthase kinase 3alpha-specific regulation of murine hepatic glycogen metabolism
    Katrina MacAulay
    Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Toronto, ON M5G 1X5, Canada
    Cell Metab 6:329-37. 2007
  7. doi Simultaneous Cre-mediated conditional knockdown of two genes in mice
    Patricia Steuber-Buchberger
    Institute for Developmental Genetics, GSF National Research Center for Environment and Health, Ingolstadter Landstr 1, Munich Neuherberg, Germany
    Genesis 46:144-51. 2008
  8. doi Glycogen synthase kinase-3 inactivation is not required for ischemic preconditioning or postconditioning in the mouse
    Yasuhiro Nishino
    King s College London BHF Centre, Cardiovascular Division, The Rayne Institute, St Thomas Hospital, UK
    Circ Res 103:307-14. 2008
  9. doi Proteinuria in mice expressing PKB/SGK-resistant GSK3
    Krishna M Boini
    Dept of Physiology, Univ of Tübingen, Gmelinstr 5, D 72076, Tubingen, Germany
    Am J Physiol Renal Physiol 296:F153-9. 2009
  10. pmc Distinct roles of GSK-3alpha and GSK-3beta phosphorylation in the heart under pressure overload
    Takahisa Matsuda
    Department of Cell Biology and Molecular Medicine, Cardiovascular Research Institute, UMDNJ New Jersey Medical School, Newark, NJ 07103, USA
    Proc Natl Acad Sci U S A 105:20900-5. 2008

Research Grants

  1. EXERCISE HYPERTROPHY AND CONTROL OF MYOSIN INDUCTION
    Richard Tsika; Fiscal Year: 2008
  2. ALTERED MECHANICAL LOADS AND SKELETAL MUSCLE PHENOTYPE
    Richard Tsika; Fiscal Year: 2009
  3. Research Echocardiography System
    Thomas Force; Fiscal Year: 2004
  4. Cytosolic Phospholipase A2 in Cardiac Hypertrophy
    Thomas Force; Fiscal Year: 2005

Scientific Experts

  • Richard W Tsika
  • Shigeki Miyamoto
  • Meghan Morgan-Smith
  • Eleonore Beurel
  • Thomas Force
  • Qiuqian Wu
  • F Beier
  • Oksana Kaidanovich-Beilin
  • James R Woodgett
  • Bradley W Doble
  • Kei Sakamoto
  • Woo Yang Kim
  • Jibin Zhou
  • Philipp Gobrecht
  • Ian G Webb
  • Richard S Jope
  • Satish Patel
  • Tae Yeon Eom
  • Hind Lal
  • S Radulescu
  • S Patel
  • Florian Lang
  • Michale Bouskila
  • Junichi Sadoshima
  • Katrina MacAulay
  • Peiyong Zhai
  • Roger W Hunter
  • James Woodgett
  • Erhe Gao
  • O J Sansom
  • R A Ridgway
  • J Woodgett
  • Dario R Alessi
  • Yasuhiro Maejima
  • Edward J McManus
  • Anthony P Popkie
  • James E Clark
  • Michael S Marber
  • Minsoo Oh
  • Yukako Yokota
  • Yasuhiro Nishino
  • William D Snider
  • Rachel C Besing
  • Andrew T Reid
  • Dietmar Fischer
  • Anastasia Andreadaki
  • Marco Leibinger
  • Chia Hsin Wu
  • Minhan Ka
  • Min Wan
  • Hongyan Li
  • Hervé Maurin
  • Samantha F Moore
  • Antonella Russo
  • Annalisa Cavallini
  • Ronald J Vagnozzi
  • Firdos Ahmad
  • Mark Chen
  • David E Hurtado
  • Saiqun Li
  • Shozo Itoh
  • J R Paul
  • Muhammet F Gulen
  • Hui Cao
  • William B Barrell
  • Shefalee K Bhavsar
  • Jeffery D Molkentin
  • John Farber
  • Xiying Shang
  • Madhuri Bhandaru
  • Wenting Yang
  • Frankie H F Lee
  • J R Gillespie
  • Celine Charvet
  • Kevin F Kelly
  • François Vigneron
  • I Ahmad
  • Naohiro Yamaguchi
  • Sejeong Shin
  • Morgan Decaul
  • Juliet C Russell
  • Jason Wray
  • Marjelo A Mines
  • Abigail Polter
  • Zhong Wang
  • Fanny Pilot-Storck
  • Anand Rotte
  • Mie Shinohara
  • Fenglei He
  • Christopher J Phiel

Detail Information

Publications103 found, 100 shown here

  1. pmc Role that phosphorylation of GSK3 plays in insulin and Wnt signalling defined by knockin analysis
    Edward J McManus
    MRC Protein Phosphorylation Unit, MSI WTB complex, University of Dundee, Dundee, Scotland
    EMBO J 24:1571-83. 2005
    ..These results establish the function of Ser21/Ser9 phosphorylation in several processes in which GSK3 inactivation has previously been implicated...
  2. ncbi Role of the PDK1-PKB-GSK3 pathway in regulating glycogen synthase and glucose uptake in the heart
    Alfonso Mora
    MRC Protein Phosphorylation Unit, School of Life Sciences, MSI WTB complex, University of Dundee, Dow Street, Dundee DD1 5EH, Scotland
    FEBS Lett 579:3632-8. 2005
    ....
  3. pmc Essential roles for GSK-3s and GSK-3-primed substrates in neurotrophin-induced and hippocampal axon growth
    Woo Yang Kim
    UNC Neuroscience Center, University of North Carolina, Chapel Hill, North Carolina 27599, USA
    Neuron 52:981-96. 2006
    ..Our results suggest that GSK-3 is a downstream convergent point for many axon growth regulatory pathways and that differential regulation of primed versus all GSK-3 substrates is associated with a specific morphological outcome...
  4. pmc Functional redundancy of GSK-3alpha and GSK-3beta in Wnt/beta-catenin signaling shown by using an allelic series of embryonic stem cell lines
    Bradley W Doble
    Samuel Lunenfeld Research Institute, Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Toronto, Ontario M5G 1X5, Canada
    Dev Cell 12:957-71. 2007
    ..The rheostatic regulation of GSK-3 highlights the importance of considering the contributions of both homologs when studying GSK-3 functions in mammalian systems...
  5. ncbi Glycogen synthase kinase-3alpha reduces cardiac growth and pressure overload-induced cardiac hypertrophy by inhibition of extracellular signal-regulated kinases
    Peiyong Zhai
    Cardiovascular Research Institute, Department of Cell Biology and Molecular Medicine, University of Medicine and Dentistry of New Jersey, New Jersey Medical School, 185 South Orange Avenue, Newark, NJ 07103, USA
    J Biol Chem 282:33181-91. 2007
    ..The anti-hypertrophic and pro-apoptotic effect of GSK-3alpha is mediated through inhibition of ERK...
  6. ncbi Glycogen synthase kinase 3alpha-specific regulation of murine hepatic glycogen metabolism
    Katrina MacAulay
    Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Toronto, ON M5G 1X5, Canada
    Cell Metab 6:329-37. 2007
    ..We conclude that GSK-3 isoforms exhibit tissue-specific physiological functions and that GSK-3alpha KO mice are insulin sensitive, reinforcing the potential of GSK-3 as a therapeutic target for type II diabetes...
  7. doi Simultaneous Cre-mediated conditional knockdown of two genes in mice
    Patricia Steuber-Buchberger
    Institute for Developmental Genetics, GSF National Research Center for Environment and Health, Ingolstadter Landstr 1, Munich Neuherberg, Germany
    Genesis 46:144-51. 2008
    ..We applied this technique to silence the widely coexpressed gene pairs Gsk-3alpha/Gsk-3beta and Erk1/Erk2 in murine embryonic stem cells and in the mouse brain...
  8. doi Glycogen synthase kinase-3 inactivation is not required for ischemic preconditioning or postconditioning in the mouse
    Yasuhiro Nishino
    King s College London BHF Centre, Cardiovascular Division, The Rayne Institute, St Thomas Hospital, UK
    Circ Res 103:307-14. 2008
    ..Our results, which include a novel genetic approach, suggest that the inhibition of GSK-3 is unlikely to be the key determinant of cardioprotective signaling in either preconditioning or postconditioning in the mouse...
  9. doi Proteinuria in mice expressing PKB/SGK-resistant GSK3
    Krishna M Boini
    Dept of Physiology, Univ of Tübingen, Gmelinstr 5, D 72076, Tubingen, Germany
    Am J Physiol Renal Physiol 296:F153-9. 2009
    ..The observations reveal that disruption of PKB/SGK-dependent regulation of GSK3 leads to glomerular injury with proteinuria, which may at least partially be secondary to enhanced blood pressure...
  10. pmc Distinct roles of GSK-3alpha and GSK-3beta phosphorylation in the heart under pressure overload
    Takahisa Matsuda
    Department of Cell Biology and Molecular Medicine, Cardiovascular Research Institute, UMDNJ New Jersey Medical School, Newark, NJ 07103, USA
    Proc Natl Acad Sci U S A 105:20900-5. 2008
    ....
  11. pmc Blocked inhibitory serine-phosphorylation of glycogen synthase kinase-3alpha/beta impairs in vivo neural precursor cell proliferation
    Tae Yeon Eom
    Department of Psychiatry, Behavioral Neurobiology, University of Alabama at Birmingham, Birmingham, Alabama 35294 0017, USA
    Biol Psychiatry 66:494-502. 2009
    ..Because these diseases might be associated with inadequately controlled glycogen synthase kinase-3 (GSK3), we tested whether blocked inhibitory serine-phosphorylation of GSK3 impairs neurogenesis...
  12. pmc GSK-3 is a master regulator of neural progenitor homeostasis
    Woo Yang Kim
    Neuroscience Center, University of North Carolina School of Medicine, Chapel Hill, North Carolina, USA
    Nat Neurosci 12:1390-7. 2009
    ..Our results indicate that GSK-3 signaling is an essential mediator of homeostatic controls that regulate neural progenitors during mammalian brain development...
  13. pmc Abnormalities in brain structure and behavior in GSK-3alpha mutant mice
    Oksana Kaidanovich-Beilin
    Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Toronto, ON M5G 1X5, Canada
    Mol Brain 2:35. 2009
    ..In this study, we have characterized brain functions of GSK-3alpha KO mice by using a well-established battery of behavioral tests together with neurochemical and neuroanatomical analysis...
  14. pmc Constitutive glycogen synthase kinase-3alpha/beta activity protects against chronic beta-adrenergic remodelling of the heart
    Ian G Webb
    Division of Cardiology, King s College London BHF Centre, The Rayne Institute, St Thomas Hospital, Lambeth Palace Road, London SE1 7EH, UK
    Cardiovasc Res 87:494-503. 2010
    ....
  15. pmc GSK-3alpha directly regulates beta-adrenergic signaling and the response of the heart to hemodynamic stress in mice
    Jibin Zhou
    Thomas Jefferson University, Philadelphia, Pennsylvania 19107, USA
    J Clin Invest 120:2280-91. 2010
    ..b>Gsk3a(-/-) mice over 2 months of age developed progressive cardiomyocyte and cardiac hypertrophy and contractile ..
  16. pmc Glycogen synthase kinase-3 regulates inflammatory tolerance in astrocytes
    E Beurel
    Department of Psychiatry and Behavioral Neurobiology, University of Alabama at Birmingham, Birmingham, AL 35294 0017, USA
    Neuroscience 169:1063-70. 2010
    ..These findings identify the critical role of GSK3 in counteracting IL-6 inflammatory tolerance in cells of the CNS, supporting the therapeutic potential of GSK3 inhibitors to reduce neuroinflammation by promoting tolerance...
  17. pmc Gsk3β is required in the epithelium for palatal elevation in mice
    Fenglei He
    Department of Cell and Molecular Biology, Tulane University, New Orleans, Louisiana 70118, USA
    Dev Dyn 239:3235-46. 2010
    ..Our results indicate that Gsk3β is an intrinsic regulator required in the epithelium for palate elevation, and could act through a pathway independent of Wnt/β-catenin signaling to regulate palate development...
  18. pmc Glycogen synthase kinase-3 is an early determinant in the differentiation of pathogenic Th17 cells
    Eleonore Beurel
    Department of Psychiatry and Behavioral Neurobiology, University of Alabama at Birmingham, Birmingham, AL 35294, USA
    J Immunol 186:1391-8. 2011
    ..These findings identify GSK3 as a critical mediator of Th17 cell production and indicate that GSK3 inhibitors provide a potential therapeutic intervention to control Th17-mediated diseases...
  19. pmc β-catenin enhances Oct-4 activity and reinforces pluripotency through a TCF-independent mechanism
    Kevin F Kelly
    Stem Cell and Cancer Research Institute, McMaster University, Hamilton, Ontario, Canada
    Cell Stem Cell 8:214-27. 2011
    ..Collectively, our data suggest previously underappreciated, divergent TCF-dependent and TCF-independent roles for β-catenin in ESCs...
  20. doi Deletion of glycogen synthase kinase-3β in cartilage results in up-regulation of glycogen synthase kinase-3α protein expression
    J R Gillespie
    Department of Physiology and Pharmacology, University of Western Ontario, London, Ontario, Canada
    Endocrinology 152:1755-66. 2011
    ..To our knowledge, this is the first tissue in which such a compensatory mechanism is described. Thus, our study provides important new insights into both skeletal development and the biology of GSK-3 proteins...
  21. pmc Selectively silencing GSK-3 isoforms reduces plaques and tangles in mouse models of Alzheimer's disease
    David E Hurtado
    Center for Neurodegenerative Disease Research, Department of Pathology and Laboratory Medicine, and Institute on Aging, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104 4283, USA
    J Neurosci 32:7392-402. 2012
    ..These findings highlight the potential importance of GSK-3α as a possible therapeutic target for ameliorating behavioral impairments linked to AD SPs and NFTs...
  22. doi GSK3 temporally regulates neurogenin 2 proneural activity in the neocortex
    Saiqun Li
    Hotchkiss Brain Institute and Alberta Children s Hospital Research Institute, Department of Biochemistry, University of Calgary, Calgary, Alberta T2N 4N1, Canada
    J Neurosci 32:7791-805. 2012
    ..We thus conclude that the temporal regulation of Neurog2-E47 heterodimerization by GSK3 is a central component of the neuronal differentiation "clock" that coordinates the timing and tempo of neocortical neurogenesis in mouse...
  23. doi AKT/SGK-sensitive phosphorylation of GSK3 in the regulation of L-selectin and perforin expression as well as activation induced cell death of T-lymphocytes
    Shefalee K Bhavsar
    Department of Physiology, University of Tubingen, Germany
    Biochem Biophys Res Commun 425:6-12. 2012
    ..In conclusion, PKB/Akt and SGK sensitive phosphorylation of GSK3α,β is a potent regulator of perforin expression and activation induced cell death in T lymphocytes...
  24. pmc Unique and overlapping functions of GSK-3 isoforms in cell differentiation and proliferation and cardiovascular development
    Thomas Force
    Center for Translational Medicine, Cardiology Division, and Program in Cell and Developmental Biology, Thomas Jefferson University, Philadelphia, Pennsylvania 19107, USA
    J Biol Chem 284:9643-7. 2009
    ....
  25. ncbi An Akt/beta-arrestin 2/PP2A signaling complex mediates dopaminergic neurotransmission and behavior
    Jean Martin Beaulieu
    Department of Cell Biology, Center for Models of Human Disease, Institute for Genome Sciences and Policy, Duke University Medical Center, Durham, North Carolina 27710, USA
    Cell 122:261-73. 2005
    ....
  26. pmc Deficiency in the inhibitory serine-phosphorylation of glycogen synthase kinase-3 increases sensitivity to mood disturbances
    Abigail Polter
    Department of Psychiatry and Behavioral Neurobiology, University of Alabama at Birmingham, Birmingham, AL 35294 0017, USA
    Neuropsychopharmacology 35:1761-74. 2010
    ....
  27. pmc GSK-3 promotes conditional association of CREB and its coactivators with MEIS1 to facilitate HOX-mediated transcription and oncogenesis
    Zhong Wang
    Department of Pathology, Stanford University School of Medicine, Stanford, CA 94305, USA
    Cancer Cell 17:597-608. 2010
    ....
  28. pmc Neuronal pentraxin 1 induction in hypoxic-ischemic neuronal death is regulated via a glycogen synthase kinase-3α/β dependent mechanism
    Juliet C Russell
    The Hugo W Moser Research Institute at Kennedy Krieger, Baltimore, MD 21205, USA
    Cell Signal 23:673-82. 2011
    ..Our findings clearly implicate both GSK-3α- and GSK-3β-dependent mechanism of NP1 induction and point to a novel mechanism in the regulation of hypoxic-ischemic neuronal death...
  29. pmc GSK-3α and GSK-3β proteins are involved in early stages of chondrocyte differentiation with functional redundancy through RelA protein phosphorylation
    Shozo Itoh
    Department of Sensory and Motor System Medicine, Faculty of Medicine, University of Tokyo, Hongo 7 3 1, Tokyo 113 8655, Japan
    J Biol Chem 287:29227-36. 2012
    ..Although knock-out of both alleles of Gsk3a (Gsk3a(-/-)) or a single allele of Gsk3b (Gsk3b(+/-)) in mice did not significantly affect skeletal development, ..
  30. pmc Constitutively active MEK1 rescues cardiac dysfunction caused by overexpressed GSK-3α during aging and hemodynamic pressure overload
    Yasuhiro Maejima
    Cardiovascular Research Institute, Department of Cell Biology and Molecular Medicine, University of Medicine and Dentistry, New Jersey, New Jersey Medical School, Newark, New Jersey 07103, USA
    Am J Physiol Heart Circ Physiol 303:H979-88. 2012
    ..In conclusion, inhibition of the MEK1/ERK pathway mediates the hypertrophy suppression and cardiac dysfunction caused by GSK-3α overexpression in cardiac myocytes...
  31. pmc Disruption of circadian rhythmicity and suprachiasmatic action potential frequency in a mouse model with constitutive activation of glycogen synthase kinase 3
    J R Paul
    Department of Psychiatry and Behavioral Neurobiology, University of Alabama at Birmingham, Birmingham, AL 35294 0017, USA
    Neuroscience 226:1-9. 2012
    ..Because GSK3 has been implicated in numerous pathologies, understanding how GSK3 modulates circadian rhythms and neurophysiological activity may lead to novel therapeutics for pathological disorders and circadian rhythm dysfunction...
  32. pmc Regulation of Th1 cells and experimental autoimmune encephalomyelitis by glycogen synthase kinase-3
    Eleonore Beurel
    Department of Psychiatry and Behavioral Sciences, Miller School of Medicine, University of Miami, Miami, FL 33136, USA
    J Immunol 190:5000-11. 2013
    ....
  33. pmc An unbiased approach to identifying tau kinases that phosphorylate tau at sites associated with Alzheimer disease
    Annalisa Cavallini
    Eli Lilly and Company Limited, Erl Wood Manor, Sunninghill Road, Windlesham, Surrey GU20 6PH, United Kingdom
    J Biol Chem 288:23331-47. 2013
    ..The findings identify novel tau kinases and novel pathways that may be relevant for AD and other tauopathies. ..
  34. doi Sustained GSK3 activity markedly facilitates nerve regeneration
    Philipp Gobrecht
    Division of Experimental Neurology, Department of Neurology, Heinrich Heine University of Dusseldorf, Merowingerplatz 1a, 40225 Dusseldorf, Germany
    Nat Commun 5:4561. 2014
    ..Therefore, suppression of this internal 'regenerative break' may potentially provide a new perspective for the clinical treatment of nerve injuries. ..
  35. pmc mTOR regulates brain morphogenesis by mediating GSK3 signaling
    Minhan Ka
    Developmental Neuroscience, Munroe Meyer Institute, University of Nebraska Medical Center, Omaha, NE 68198, USA
    Development 141:4076-86. 2014
    ..Our findings reveal that the interaction between mTOR and GSK3 signaling plays an essential role in dynamic homeostasis of neural progenitors during brain development...
  36. doi Nucleocapsid phosphorylation and RNA helicase DDX1 recruitment enables coronavirus transition from discontinuous to continuous transcription
    Chia Hsin Wu
    Department of Microbiology, National Taiwan University College of Medicine, No 1, Jen Ai Road, Section 1, Taipei 10051, Taiwan
    Cell Host Microbe 16:462-72. 2014
    ..Thus, coronaviruses employ a unique strategy for the transition from discontinuous to continuous transcription to ensure balanced sgmRNAs and full-length gRNA synthesis...
  37. pmc Circadian rhythmicity of active GSK3 isoforms modulates molecular clock gene rhythms in the suprachiasmatic nucleus
    Rachel C Besing
    Department of Psychiatry and Behavioral Neurobiology
    J Biol Rhythms 30:155-60. 2015
    ..These results support the model that GSK3 activity status is regulated by the circadian clock and that GSK3 feeds back to regulate the molecular clock amplitude in the SCN. ..
  38. doi Glycogen synthase kinase 3 regulates acrosomal exocytosis in mouse spermatozoa via dynamin phosphorylation
    Andrew T Reid
    School of Environmental and Life Sciences, Discipline of Biological Sciences, and School of Environmental and Life Sciences, Discipline of Chemistry, The University of Newcastle, Callaghan, New South Wales, Australia and Children s Medical Research Institute, The University of Sydney, Westmead, New South Wales, Australia
    FASEB J 29:2872-82. 2015
    ..These data reveal a novel mode for the cellular acquisition of a protein kinase and identify a key role for GSK3 in the regulation of sperm maturation and acrosomal exocytosis...
  39. doi Promotion of Functional Nerve Regeneration by Inhibition of Microtubule Detyrosination
    Philipp Gobrecht
    Division of Experimental Neurology, Department of Neurology, Medical Faculty, Heinrich Heine University of Dusseldorf, 40225 Dusseldorf, Germany
    J Neurosci 36:3890-902. 2016
    ..Thus, reducing microtubule detyrosination in axonal tips may be a novel, clinically suitable strategy to treat nerve damage...
  40. pmc Neurological characterization of mice deficient in GSK3α highlight pleiotropic physiological functions in cognition and pathological activity as Tau kinase
    Hervé Maurin
    Department Human Genetics, Experimental Genetics Group LEGTEGG, KULeuven, Leuven, Belgium
    Mol Brain 6:27. 2013
    ..In contrast, the GSK3α isozyme remained largely ignored with respect to both aspects...
  41. doi PKB/SGK-dependent GSK3-phosphorylation in the regulation of LPS-induced Ca2+ increase in mouse dendritic cells
    Antonella Russo
    Department of Physiology, University of Tubingen, Gmelinstr 5, Germany
    Biochem Biophys Res Commun 437:336-41. 2013
    ..In conclusion, PKB/SGK-dependent GSK3α,β activity participates in the regulation of Ca(2+) signaling in dendritic cells. ..
  42. pmc Glycogen synthase kinase-3 promotes the synergistic action of interferon-gamma on lipopolysaccharide-induced IL-6 production in RAW264.7 cells
    Eleonore Beurel
    Department of Psychiatry and Behavioral Neurobiology, 1720 Seventh Avenue South, University of Alabama at Birmingham, Birmingham, AL 35294 0017, USA
    Cell Signal 21:978-85. 2009
    ..These results demonstrate the dependency of macrophage priming by IFN-gamma on STAT3 and GSK3, providing novel targets for intervention...
  43. doi GSK-3β at the crossroads in the signalling of heart preconditioning: implication of mTOR and Wnt pathways
    François Vigneron
    Inserm Unit 828, Pessac, France
    Cardiovasc Res 90:49-56. 2011
    ..Here, we investigate whether the mTOR pathway is involved in cardioprotection...
  44. pmc Glycogen synthase kinase (GSK)-3 promotes p70 ribosomal protein S6 kinase (p70S6K) activity and cell proliferation
    Sejeong Shin
    Department of Cancer and Cell Biology, University of Cincinnati College of Medicine, Cincinnati, OH 45267, USA
    Proc Natl Acad Sci U S A 108:E1204-13. 2011
    ..Our unexpected results provide a clear rationale for the development and use of drugs targeting GSK-3 to treat diseases such as diabetes, cancer, and age-related diseases that are linked to improper regulation of S6K1...
  45. pmc Glycogen synthase kinase-3α limits ischemic injury, cardiac rupture, post-myocardial infarction remodeling and death
    Hind Lal
    Center for Translational Medicine, Thomas Jefferson University, College Building, rm 316, 1025 Walnut St, Philadelphia, PA 19107, USA
    Circulation 125:65-75. 2012
    ..We recently demonstrated that glycogen synthase kinase-3α (GSK-3α) is critical to the heart's response to pressure overload. However, the role, if any, of GSK-3α in regulating ischemic injury and its consequences is not known...
  46. pmc GSK3 inhibitor-BIO regulates proliferation of immortalized pancreatic mesenchymal stem cells (iPMSCs)
    Hui Cao
    College of Veterinary Medicine, Shaanxi Center of Stem Cells Engineering and Technology, Key Lab for Animal Biotechnology of Agriculture Ministry of China, Northwest A and F University, Yangling, Shaanxi, People s Republic of China
    PLoS ONE 7:e31502. 2012
    ..However, the precise role of GSK3 in immortalized pancreatic mesenchymal stem cells (iPMSCs) growth and survival is not completely understood at present...
  47. pmc Acute WNT signalling activation perturbs differentiation within the adult stomach and rapidly leads to tumour formation
    S Radulescu
    CR UK Beatson Institute of Cancer Research, Glasgow, UK
    Oncogene 32:2048-57. 2013
    ..Furthermore, our inducible murine model will permit a better understanding of the molecular changes required to drive tumourigenesis in the stomach...
  48. ncbi Spatially coordinated kinase signaling regulates local axon degeneration
    Mark Chen
    Department of Neuroscience, Genentech, Inc, South San Francisco, California 94080, USA
    J Neurosci 32:13439-53. 2012
    ..Additionally, we identify the dleu2/mir15a/16-1 cluster, previously characterized as a regulator of B-cell proliferation, and the transcription factor tbx6, as likely downstream effectors of GSK3β in axon degeneration...
  49. pmc Inactivation of the enzyme GSK3α by the kinase IKKi promotes AKT-mTOR signaling pathway that mediates interleukin-1-induced Th17 cell maintenance
    Muhammet F Gulen
    Department of Immunology, Lerner Research Institute, Cleveland Clinic Foundation, Cleveland, OH 44195, USA
    Immunity 37:800-12. 2012
    ..Thus, IKKi has a critical role in Th17 cell maintenance and/or proliferation through the GSK-AKT-mTOR pathway, implicating the potential of IKKi as a therapeutic target...
  50. pmc Glycogen synthase kinase-3 levels and phosphorylation undergo large fluctuations in mouse brain during development
    Eleonore Beurel
    Departments of Psychiatry and Biochemistry, Miller School of Medicine, University of Miami, Miami, FL, USA
    Bipolar Disord 14:822-30. 2012
    ....
  51. pmc Novel reporter alleles of GSK-3α and GSK-3β
    William B Barrell
    Department of Craniofacial Development and Stem Cell Biology, King s College London, London, United Kingdom
    PLoS ONE 7:e50422. 2012
    ..Finally, we observed gestational lethality in compound GSK-3β(-/-); GSK3α(+/-) mutants, suggesting that GSK-3 dosage is critical during embryonic development...
  52. pmc Dual regulation of glycogen synthase kinase 3 (GSK3)α/β by protein kinase C (PKC)α and Akt promotes thrombin-mediated integrin αIIbβ3 activation and granule secretion in platelets
    Samantha F Moore
    School of Physiology and Pharmacology, School of Medical Sciences, University of Bristol, Bristol BS8 1TD, United Kingdom
    J Biol Chem 288:3918-28. 2013
    ..Together, these results demonstrate that PKCα and Akt modulate platelet function by phosphorylating and inhibiting GSK3α/β, thereby relieving the negative effect of GSK3α/β on thrombin-mediated platelet activation...
  53. pmc GSK-3α is a central regulator of age-related pathologies in mice
    Jibin Zhou
    Center for Translational Medicine, Temple University School of Medicine, Philadelphia, Pennsylvania 19140, USA
    J Clin Invest 123:1821-32. 2013
    ..Herein, we demonstrate premature death and acceleration of age-related pathologies in the Gsk3a global KO mouse...
  54. doi Glycogen synthase kinase 3 alpha phosphorylates and regulates the osteogenic activity of Osterix
    Hongyan Li
    College of Pharmacy and Research Institute of Drug Development, Chonnam National University, Gwangju, Republic of Korea
    Biochem Biophys Res Commun 434:653-8. 2013
    ..The function of Osterix can be modulated by post-translational modification. Glycogen synthase kinase 3 alpha (GSK3α) is a multifunctional serine/threonine protein kinase that plays a role in the Wnt signaling ..
  55. pmc A noncanonical, GSK3-independent pathway controls postprandial hepatic glycogen deposition
    Min Wan
    The Institute for Diabetes, Obesity, and Metabolism, University of Pennsylvania, Philadelphia, PA 19104, USA
    Cell Metab 18:99-105. 2013
    ....
  56. ncbi Regulation of Wnt signaling during adipogenesis
    Christina N Bennett
    Department of Physiology, 7620 Medical Science II, University of Michigan Medical School, 1301 E Catherine Street, Ann Arbor, MI 48109 0622, USA
    J Biol Chem 277:30998-1004. 2002
    ..Finally, we demonstrate that disruption of extracellular Wnt signaling by expression of secreted Frizzled related proteins causes spontaneous adipocyte conversion...
  57. ncbi Generation of a floxed allele of Smad5 for cre-mediated conditional knockout in the mouse
    Lieve Umans
    Department of Developmental Biology VIB 7, Flanders Interuniversity Institute for Biotechnology VIB, and Laboratory of Molecular Biology Celgen, University of Leuven, Leuven, Belgium
    Genesis 37:5-11. 2003
    ..Smad5(flE2/flE2) mice are now available and will be a valuable tool to analyze the role of Smad5 beyond its crucial early embryonic function throughout development and postnatal life...
  58. ncbi Beta-catenin is temporally regulated during normal liver development
    Amanda Micsenyi
    Department of Pathology, University of Pittsburgh, School of Medicine, PA 15261, USA
    Gastroenterology 126:1134-46. 2004
    ..beta-Catenin, a key component of the Wnt pathway, plays an important role in unregulated liver growth in liver tumors, in regulated growth during liver regeneration, and in ex vivo embryonic liver cultures...
  59. pmc Wnt10b deficiency promotes coexpression of myogenic and adipogenic programs in myoblasts
    Anthony M Vertino
    Donald W Reynolds Department of Geriatrics, University of Arkansas for Medical Sciences, Little Rock, 72205, USA
    Mol Biol Cell 16:2039-48. 2005
    ..Thus, alteration in Wnt signaling in myoblasts with age may contribute to impaired muscle regenerative capacity and to increased muscle adiposity, both characteristic of aged muscle...
  60. ncbi PI3K-AKT pathway mediates growth and survival signals during development of fetal mouse lung
    J Wang
    Department of Pathology, Yokohama City University Graduate School of Medicine, Yokohama, Japan
    Tissue Cell 37:25-35. 2005
    ..The LY294002 and wortmannin treatments showed decreased expression of SPC. These findings suggest that the PI3K-AKT signalling pathway plays a pivotal role in mouse lung development through various biological processes...
  61. pmc Analysis of hepatic gene transcription in mice expressing insulin-insensitive GSK3
    Christopher Lipina
    Division of Pathology and Neurosciences, University of Dundee, Ninewells Hospital, Dundee DD1 9SY, Scotland, UK
    Biochem J 392:633-9. 2005
    ..We suggest for the first time that although pharmacological inhibition of GSK3 reduces hepatic glucose production even in insulin-resistant states, feeding can repress the gluconeogenic genes without inhibiting GSK3...
  62. ncbi Glycogen synthase kinase-3 regulation of chromatin segregation and cytokinesis in mouse preimplantation embryos
    Nicole Acevedo
    Department of Molecular, University of Michigan, Ann Arbor, Michigan, USA
    Mol Reprod Dev 74:178-88. 2007
    ..Inhibition of GSK-3 also resulted in abnormal chromatin segregation, evidenced by incomplete karyokinesis and micronuclei formation. These results suggest that GSK-3 activity is critical for early preimplantation embryonic development...
  63. pmc S6K1 regulates GSK3 under conditions of mTOR-dependent feedback inhibition of Akt
    Hui H Zhang
    Department of Genetics and Complex Diseases, Harvard School of Public Health, Harvard Medical School, Boston, Massachusetts 02115, USA
    Mol Cell 24:185-97. 2006
    ..We find that GSK3 can also be regulated downstream of mTORC1 in a HepG2 model of cellular insulin resistance. Therefore, we define conditions in which S6K1, rather than Akt, is the predominant GSK3 regulatory kinase...
  64. pmc Glycogen synthase kinase 3alpha and 3beta mediate a glucose-sensitive antiapoptotic signaling pathway to stabilize Mcl-1
    Yuxing Zhao
    Department of Pharmacology and Cancer Biology, DUMC Box 3813, Durham, NC 27710, USA
    Mol Cell Biol 27:4328-39. 2007
    ....
  65. ncbi GSK3 alpha and GSK3 beta are necessary for axon formation
    Juan Jose Garrido
    Centro de Biologia Molecular Severo Ochoa, Facultad de Ciencias, CSIC Universidad Autonoma de Madrid, Cantoblanco, Madrid, Spain
    FEBS Lett 581:1579-86. 2007
    ..Moreover, interference RNAs impeding the expression of the GSK3 alpha or beta isoforms in hippocampal neurons prevents an axon from forming...
  66. pmc Neuronal apoptosis and reversible motor deficit in dominant-negative GSK-3 conditional transgenic mice
    Raquel Gómez-Sintes
    Centro de Biologia Molecular Severo Ochoa, CSIC UAM, Madrid, Spain
    EMBO J 26:2743-54. 2007
    ..Interestingly, the reversibility data also suggest that unwanted side effects are likely to revert if excessive GSK-3 inhibition is halted...
  67. pmc Neural precursor cells are protected from apoptosis induced by trophic factor withdrawal or genotoxic stress by inhibitors of glycogen synthase kinase 3
    Tae Yeon Eom
    Department of Psychiatry and Behavioral Neurobiology, University of Alabama at Birmingham, Birmingham, Alabama 35294 0017, USA
    J Biol Chem 282:22856-64. 2007
    ..Thus, NPCs are sensitive to loss of trophic factors and genotoxic stress, and inhibitors of GSK3 are capable of enhancing NPC survival...
  68. ncbi N-terminal cleavage of GSK-3 by calpain: a new form of GSK-3 regulation
    Paloma Goñi-Oliver
    Centro de Biologia Molecular Severo Ochoa, Consejo Superior de Investigaciones Cientificas Universidad Autónoma CSIC UAM, Fac Ciencias, Universidad Autonoma de Madrid, Cantoblanco, 28049 Madrid, Spain
    J Biol Chem 282:22406-13. 2007
    ..These data provide the first direct evidence that calpain promotes GSK-3 truncation in a way that has implications in signal transduction, and probably in pathological disorders such as Alzheimer disease...
  69. pmc MafA stability in pancreatic beta cells is regulated by glucose and is dependent on its constitutive phosphorylation at multiple sites by glycogen synthase kinase 3
    Song Iee Han
    Laboratory of Molecular and Developmental Biology, Graduate School of Biological Science, Nara Institute of Science and Technology, Ikoma, Japan
    Mol Cell Biol 27:6593-605. 2007
    ..Our data suggest a new glucose-sensing signaling pathway in islet beta cells that regulates insulin gene expression through the regulation of MafA protein stability...
  70. ncbi Wnt5a modulates glycogen synthase kinase 3 to induce phosphorylation of receptor tyrosine kinase Ror2
    Hiroyuki Yamamoto
    Department of Physiology and Cell Biology, Faculty of Medical Sciences, Graduate School of Medicine, Kobe University, 7 5 1, Kusunoki cho, Chuo Ku, Kobe 650 0017, Japan
    Genes Cells 12:1215-23. 2007
    ..Moreover, it was found that Wnt5a-induced cell migration can be inhibited by SB216763 or by siRNA-mediated suppression of GSK-3alpha (and GSK-3beta) expression, further emphasizing the role(s) of GSK-3 in Wnt5a-induced signaling...
  71. ncbi Insulin promotes glycogen synthesis in the absence of GSK3 phosphorylation in skeletal muscle
    Michale Bouskila
    Am J Physiol Endocrinol Metab 294:E28-35. 2008
    ..This suggests that allosteric regulation of GS by G-6-P may play a key role in insulin-stimulated muscle glycogen synthesis in vivo...
  72. pmc Overexpression of Smurf2 stimulates endochondral ossification through upregulation of beta-catenin
    Qiuqian Wu
    Department of Orthopaedics, Center for Musculoskeletal Research, University of Rochester Medical Center, 601 Elmwood Avenue, Box 665, Rochester, New York 14642, USA
    J Bone Miner Res 23:552-63. 2008
    ..The mechanism underlying Smurf2-mediated morphological changes during embryonic development may provide new mechanistic insights and potential targets for prevention and treatment of human osteoarthritis...
  73. pmc The Wnt pool of glycogen synthase kinase 3beta is critical for trophic-deprivation-induced neuronal death
    Vesa Hongisto
    Turku Centre for Biotechnology, Turku University and Abo Akademi University, BioCity, Tykistokatu 6, Turku FIN 20521, Finland
    Mol Cell Biol 28:1515-27. 2008
    ..These data imply that Wnt-regulated GSK-3beta plays a nonredundant role in trophic-deprivation-induced death of neurons...
  74. doi Phosphorylation of Ser357 of rat insulin receptor substrate-1 mediates adverse effects of protein kinase C-delta on insulin action in skeletal muscle cells
    Rizwana Sanaullah Waraich
    Division of Clinical Chemistry and Pathobiochemistry, University of Tuebingen, Tuebingen, Germany
    J Biol Chem 283:11226-33. 2008
    ..Together, these data suggest that phosphorylation of Ser(357) mediates at least in part the adverse effects of PKC-delta activation on insulin action...
  75. pmc Differential regulation of STAT family members by glycogen synthase kinase-3
    Eleonore Beurel
    Department of Psychiatry and Behavioral Neurobiology, University of Alabama, Birmingham, Alabama 35294 0017, USA
    J Biol Chem 283:21934-44. 2008
    ..Thus, inhibitors of GSK3 reduce the activation of STAT3 and STAT5, providing a mechanism to differentially regulate STATs to modulate the inflammatory response...
  76. pmc Phosphorylation of GSK-3beta by cGMP-dependent protein kinase II promotes hypertrophic differentiation of murine chondrocytes
    Yosuke Kawasaki
    Sensory and Motor System Medicine, Faculty of Medicine, University of Tokyo, Tokyo, Japan
    J Clin Invest 118:2506-15. 2008
    ..These data indicate that hypertrophic differentiation of growth plate chondrocytes during skeletal growth is promoted by phosphorylation and inactivation of GSK-3beta by cGKII...
  77. doi Immunohistochemical study on the distribution of glycogen synthase kinase 3alpha in the central nervous system of SOD1(G93A) transgenic mice
    Yoon Hee Chung
    Department of Anatomy, College of Medicine, Chung Ang University, 221 Heukseok dong, Dongjak Gu, Seoul, Korea
    Neurol Res 30:926-31. 2008
    ....
  78. pmc Overexpression of TEAD-1 in transgenic mouse striated muscles produces a slower skeletal muscle contractile phenotype
    Richard W Tsika
    Department of Biochemistry, School of Medicine, University of Missouri, Columbia, Missouri 65211, USA
    J Biol Chem 283:36154-67. 2008
    ..These novel in vivo data support a role for TEAD-1 in modulating slow muscle gene expression...
  79. doi Regulation of Notch1/NICD and Hes1 expressions by GSK-3alpha/beta
    Yun Hye Jin
    College of Pharmacy and Research Institute of Drug Development, Chonnam National University, Gwangju, 500 757, Korea
    Mol Cells 27:15-9. 2009
    ..Taken together, our results indicate that GSK-3alpha is a negative regulator of Notch1/NICD...
  80. doi Akt regulates skeletal development through GSK3, mTOR, and FoxOs
    Satoshi Rokutanda
    Department of Cell Biology, Unit of Basic Medical Sciences, Nagasaki University Graduate School of Biomedical Sciences, 1 7 1 Sakamoto, Nagasaki 852 8588, Japan
    Dev Biol 328:78-93. 2009
    ....
  81. pmc GSK-3 phosphorylates delta-catenin and negatively regulates its stability via ubiquitination/proteosome-mediated proteolysis
    Minsoo Oh
    College of Pharmacy and Research Institute of Drug Development, Chonnam National University, Gwangju 500 757, Korea
    J Biol Chem 284:28579-89. 2009
    ..These results suggest that GSK-3 interacts with and phosphorylates delta-catenin and thereby negatively affects its stability by enabling its ubiquitination/proteosome-mediated proteolysis...
  82. pmc Homozygous loss of BHD causes early embryonic lethality and kidney tumor development with activation of mTORC1 and mTORC2
    Yukiko Hasumi
    Urologic Oncology Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA
    Proc Natl Acad Sci U S A 106:18722-7. 2009
    ....
  83. pmc Silencing glycogen synthase kinase-3beta inhibits acetaminophen hepatotoxicity and attenuates JNK activation and loss of glutamate cysteine ligase and myeloid cell leukemia sequence 1
    Mie Shinohara
    University of Southern California Research Center for Liver Diseases, Keck School of Medicine, University of Southern California, Los Angeles, California 90089 9121, USA
    J Biol Chem 285:8244-55. 2010
    ..Taken together our results suggest that activation of GSK-3beta is a key mediator of the initial phase of APAP-induced liver injury through modulating GCL and Mcl-1 degradation, as well as JNK activation in liver...
  84. pmc TEAD-1 overexpression in the mouse heart promotes an age-dependent heart dysfunction
    Richard W Tsika
    Department of Biochemistry, School of Medicine, University of Missouri, Columbia, Missouri 65211, USA
    J Biol Chem 285:13721-35. 2010
    ..These data provide the first in vivo evidence that increased TEAD-1 can induce characteristics of cardiac remodeling associated with cardiomyopathy and heart failure...
  85. pmc GSK3 influences social preference and anxiety-related behaviors during social interaction in a mouse model of fragile X syndrome and autism
    Marjelo A Mines
    Department of Psychiatry and Behavioral Neurobiology, University of Alabama at Birmingham, Birmingham, Alabama, United States of America
    PLoS ONE 5:e9706. 2010
    ..This used two mouse models with disrupted regulation of GSK3, Fmr1 knockout mice and GSK3 knockin mice, in which inhibitory serines of the two isoforms of GSK3, GSK3alpha and GSK3beta, are mutated to alanines, leaving GSK3 fully active...
  86. pmc Interactome mapping of the phosphatidylinositol 3-kinase-mammalian target of rapamycin pathway identifies deformed epidermal autoregulatory factor-1 as a new glycogen synthase kinase-3 interactor
    Fanny Pilot-Storck
    UMR5239 Laboratoire de Biologie Moléculaire de la Cellule, Ecole Normale Superieure de Lyon, Lyon, France
    Mol Cell Proteomics 9:1578-93. 2010
    ..deformed epidermal autoregulatory factor-1 (DEAF1) transcription factor as an interactor and in vitro substrate of GSK3A and GSK3B...
  87. doi Glycogen synthase kinase-3 plays a central role in mediating glucocorticoid-induced apoptosis
    Rachel Spokoini
    The Lautenberg Center of Immunology, Institute of Medical Research, Faculty of Medicine, Hebrew University, Jerusalem, Israel
    Mol Endocrinol 24:1136-50. 2010
    ..Our data suggest that targeting protein kinases involved in GSK3 inactivation should improve the outcome of GC therapy...
  88. doi Regulation of basal gastric acid secretion by the glycogen synthase kinase GSK3
    Anand Rotte
    Department of Physiology, University of Tubingen, Gmelinstrasse 5, Tubingen, Germany
    J Gastroenterol 45:1022-32. 2010
    ..PKB/Akt phosphorylates glycogen synthase kinase GSK3. The present study explored whether PKB/Akt-dependent GSK3-phosphorylation modifies gastric acid secretion...
  89. pmc Myocardial stress remodelling after regional infarction is independent of glycogen synthase kinase-3 inactivation
    Ian G Webb
    King s College London BHF Centre, The Rayne Institute, St Thomas Hospital, London SE1 7EH, UK
    J Mol Cell Cardiol 49:897-900. 2010
    ..This highlights the heterogeneity of pathological hypertrophy and the divergent role of GSK-3 signalling in chronic myocardial stress...
  90. pmc Defining the role of APC in the mitotic spindle checkpoint in vivo: APC-deficient cells are resistant to Taxol
    S Radulescu
    CR UK Beatson Institute of Cancer Research, Glasgow, UK
    Oncogene 29:6418-27. 2010
    ..In summary, this study clarifies the role of APC as a mitotic spindle checkpoint protein in vivo and shows that APC-deficient cells have a compromised response to Taxol...
  91. pmc β-Catenin activation synergizes with PTEN loss to cause bladder cancer formation
    I Ahmad
    The Beatson Institute for Cancer Research, Glasgow, Scotland, UK
    Oncogene 30:178-89. 2011
    ..Taken together these data show that deregulated Wnt signalling has a critical role in promoting UCC, and suggests that human UCC that have high levels of Wnt and PI3 kinase signalling may be responsive to mTOR inhibition...
  92. doi Allosteric regulation of glycogen synthase controls glycogen synthesis in muscle
    Michale Bouskila
    University of Dundee, Scotland, UK
    Cell Metab 12:456-66. 2010
    ..Our study provides genetic evidence that allosteric activation of GS is the primary mechanism by which insulin promotes muscle glycogen accumulation in vivo...
  93. pmc Phosphatidylinositol 3-kinase (PI3K) signaling via glycogen synthase kinase-3 (Gsk-3) regulates DNA methylation of imprinted loci
    Anthony P Popkie
    Graduate Program in Molecular, Cellular and Developmental Biology, The Ohio State University, Columbus, Ohio 43210, USA
    J Biol Chem 285:41337-47. 2010
    ..Finally, we find that N-Myc is a potent Gsk-3-dependent regulator of Dnmt3a2 expression. In summary, we have identified a signal transduction pathway that is capable of altering the DNA methylation of imprinted loci...
  94. pmc Cdc42 and Gsk3 modulate the dynamics of radial glial growth, inter-radial glial interactions and polarity in the developing cerebral cortex
    Yukako Yokota
    UNC Neuroscience Center and the Department of Cell and Molecular Physiology, The University of North Carolina School of Medicine, Chapel Hill, NC 27599, USA
    Development 137:4101-10. 2010
    ..Related cell polarity determinants (Cdc42, Gsk3) differentially influence radial glial activities within the evolving radial glia scaffold to coordinate the formation of cerebral cortex...
  95. pmc Tissue-specific analysis of glycogen synthase kinase-3α (GSK-3α) in glucose metabolism: effect of strain variation
    Satish Patel
    Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Toronto, Ontario, Canada
    PLoS ONE 6:e15845. 2011
    ..We also found that muscle (but not liver) inactivation of GSK-3β conferred insulin and glucose sensitization in an in-bred strain of mice (C57BL/6)...
  96. pmc Dysfunctional ryanodine receptor and cardiac hypertrophy: role of signaling molecules
    Naohiro Yamaguchi
    Dept of Biochemistry and Biophysics, Univ of North Carolina, Chapel Hill, NC 27599 7260, USA
    Am J Physiol Heart Circ Physiol 300:H2187-95. 2011
    ..5 hearts; rather increased Erk1/2 and p90RSK phosphorylation levels likely leading to reduced GSK-3β activity were found to precede development of cardiac hypertrophy in mice expressing dysfunctional ryanodine receptor ion channel...
  97. doi Genetic inactivation of GSK3α rescues spine deficits in Disc1-L100P mutant mice
    Frankie H F Lee
    Neuroscience Division, Centre for Addiction and Mental Health, 250 College St, Toronto, Ontario, Canada M5T 1R8
    Schizophr Res 129:74-9. 2011
    ..These findings suggest novel treatment approaches for schizophrenia, and identify a histological read-out for testing other therapeutic interventions...
  98. pmc Phosphorylation of Tip60 by GSK-3 determines the induction of PUMA and apoptosis by p53
    Celine Charvet
    Institute of Molecular Medicine and Cell Research, Albert Ludwigs University Freiburg, Stefan Meier Strasse 17, 79104 Freiburg, Germany
    Mol Cell 42:584-96. 2011
    ..Our data suggest that GSK-3 mediated Tip60S86 phosphorylation provides a link between PI3K signaling and the choice for or against apoptosis induction by p53...
  99. pmc Inhibition of glycogen synthase kinase-3 alleviates Tcf3 repression of the pluripotency network and increases embryonic stem cell resistance to differentiation
    Jason Wray
    Wellcome Trust Centre for Stem Cell Research and Department of Biochemistry, University of Cambridge, Tennis Court Road, Cambridge CB2 1QR, UK
    Nat Cell Biol 13:838-45. 2011
    ..We conclude that Gsk3 inhibition stabilizes the embryonic stem cell state primarily by reducing repressive influence on the core pluripotency network...
  100. ncbi The costimulation-regulated duration of PKB activation controls T cell longevity
    Jianxun Song
    Division of Molecular Immunology, La Jolla Institute for Allergy and Immunology, San Diego, CA 92121, USA
    Nat Immunol 5:150-8. 2004
    ..Thus, sustained and periodic PKB signaling has an integral role in regulating T cell longevity...

Research Grants4

  1. EXERCISE HYPERTROPHY AND CONTROL OF MYOSIN INDUCTION
    Richard Tsika; Fiscal Year: 2008
    ..abstract_text> ..
  2. ALTERED MECHANICAL LOADS AND SKELETAL MUSCLE PHENOTYPE
    Richard Tsika; Fiscal Year: 2009
    ..abstract_text> ..
  3. Research Echocardiography System
    Thomas Force; Fiscal Year: 2004
    ....
  4. Cytosolic Phospholipase A2 in Cardiac Hypertrophy
    Thomas Force; Fiscal Year: 2005
    ..abstract_text> ..