Gene Symbol: Grm5
Description: glutamate receptor, metabotropic 5
Alias: 6430542K11Rik, AI850523, Glu5R, Gprc1e, mGluR5, mGluR5b, metabotropic glutamate receptor 5, G protein-coupled receptor GRM5, G protein-coupled receptor, family C, group 1, member E, metabotropic glutamate receptor subtype 5b, metabotropic glutamate receptor type 5
Species: mouse
Products:     Grm5

Top Publications

  1. Zhang L, Alger B. Enhanced endocannabinoid signaling elevates neuronal excitability in fragile X syndrome. J Neurosci. 2010;30:5724-9 pubmed publisher
    ..Western blots revealed that levels of mGluR1, mGluR5, or cannabinoid receptor (CB1R) were unchanged in Fmr1 KO animals, suggesting that the coupling between mGluR ..
  2. Novak M, Halbout B, O Connor E, Rodriguez Parkitna J, Su T, Chai M, et al. Incentive learning underlying cocaine-seeking requires mGluR5 receptors located on dopamine D1 receptor-expressing neurons. J Neurosci. 2010;30:11973-82 pubmed publisher
    ..The metabotropic glutamate receptor, mGluR5, is potentially important in this respect; it plays a central role in several forms of striatal synaptic ..
  3. Ribeiro F, Devries R, Hamilton A, Guimaraes I, Cregan S, Pires R, et al. Metabotropic glutamate receptor 5 knockout promotes motor and biochemical alterations in a mouse model of Huntington's disease. Hum Mol Genet. 2014;23:2030-42 pubmed publisher
    ..In the present study, we show that blockade of mGluR5 with MTEP promotes increased locomotor activity in both control (Hdh(Q20/Q20)) and mutant HD (Hdh(Q111/Q111)) mice...
  4. Nishi A, Liu F, Matsuyama S, Hamada M, Higashi H, Nairn A, et al. Metabotropic mGlu5 receptors regulate adenosine A2A receptor signaling. Proc Natl Acad Sci U S A. 2003;100:1322-7 pubmed
    ..The results demonstrate that mGlu5 receptors potentiate adenosine A(2A)DARPP-32 signaling by stimulating the adenosine A(2A) receptor-mediated formation of cAMP in an extracellular signal-regulated kinase-dependent manner. ..
  5. Ribeiro F, Ferreira L, Paquet M, Cregan T, Ding Q, Gros R, et al. Phosphorylation-independent regulation of metabotropic glutamate receptor 5 desensitization and internalization by G protein-coupled receptor kinase 2 in neurons. J Biol Chem. 2009;284:23444-53 pubmed publisher
    ..Unlike mGluR1, the attenuation of mGluR5 signaling in HEK 293 cells is reported to be mediated by a phosphorylation-dependent mechanism...
  6. Brody S, Dulawa S, Conquet F, Geyer M. Assessment of a prepulse inhibition deficit in a mutant mouse lacking mGlu5 receptors. Mol Psychiatry. 2004;9:35-41 pubmed
    ..Here we identify a possible role of mGluR5 in PPI by using wild type (WT) and mGluR5 knockout (KO) mice of two different background strains, 129SvPasIco and ..
  7. Ribeiro F, Paquet M, Ferreira L, Cregan T, Swan P, Cregan S, et al. Metabotropic glutamate receptor-mediated cell signaling pathways are altered in a mouse model of Huntington's disease. J Neurosci. 2010;30:316-24 pubmed publisher
    ..Basal AKT activation is higher in Hdh(Q111/Q111) neurons and this increase is mGluR5 dependent...
  8. Pisani A, Gubellini P, Bonsi P, Conquet F, Picconi B, Centonze D, et al. Metabotropic glutamate receptor 5 mediates the potentiation of N-methyl-D-aspartate responses in medium spiny striatal neurons. Neuroscience. 2001;106:579-87 pubmed
    ..were potentiated in the presence of both the group I mGluR agonist 3,5-dihydroxyphenylglycine (3,5-DHPG) and the mGluR5 selective agonist (RS)-2-chloro-5-hydroxyphenylglycine (CHPG)...
  9. D Ascenzo M, Podda M, Fellin T, Azzena G, Haydon P, Grassi C. Activation of mGluR5 induces spike afterdepolarization and enhanced excitability in medium spiny neurons of the nucleus accumbens by modulating persistent Na+ currents. J Physiol. 2009;587:3233-50 pubmed publisher
    The involvement of metabotropic glutamate receptors type 5 (mGluR5) in drug-induced behaviours is well-established but limited information is available on their functional roles in addiction-relevant brain areas like the nucleus accumbens ..

More Information


  1. D Ascenzo M, Fellin T, Terunuma M, Revilla Sanchez R, Meaney D, Auberson Y, et al. mGluR5 stimulates gliotransmission in the nucleus accumbens. Proc Natl Acad Sci U S A. 2007;104:1995-2000 pubmed
    Although metabotropic glutamate receptor 5 (mGluR5) is essential for cocaine self-administration and drug-seeking behavior, there is limited knowledge of the cellular actions of this receptor in the nucleus accumbens (NAc)...
  2. Chiamulera C, Epping Jordan M, Zocchi A, Marcon C, Cottiny C, Tacconi S, et al. Reinforcing and locomotor stimulant effects of cocaine are absent in mGluR5 null mutant mice. Nat Neurosci. 2001;4:873-4 pubmed
    ..Here we show that mice lacking the mGluR5 gene do not self-administer cocaine, and show no increased locomotor activity following cocaine treatment, despite ..
  3. Xu J, Zhu Y, Contractor A, Heinemann S. mGluR5 has a critical role in inhibitory learning. J Neurosci. 2009;29:3676-84 pubmed publisher
    ..Using newly generated metabotropic glutamate receptor 5 (mGluR5) knock-out mice, we investigated the role of mGluR5 in the acquisition and reversal of an ..
  4. Hou L, Klann E. Activation of the phosphoinositide 3-kinase-Akt-mammalian target of rapamycin signaling pathway is required for metabotropic glutamate receptor-dependent long-term depression. J Neurosci. 2004;24:6352-61 pubmed
    ..Together, our findings indicate that activation of the PI3K-Akt-mTOR signaling cascade is required for mGluR-LTD and suggest that this pathway may couple group I mGluRs to translation initiation in hippocampal area CA1. ..
  5. Kinney G, Burno M, Campbell U, Hernandez L, Rodriguez D, Bristow L, et al. Metabotropic glutamate subtype 5 receptors modulate locomotor activity and sensorimotor gating in rodents. J Pharmacol Exp Ther. 2003;306:116-23 pubmed
    ..Activation of the metabotropic glutamate receptor subtype 5 (mGluR5) enhances NMDAR-mediated currents in vitro...
  6. Brodkin J, Bradbury M, Busse C, Warren N, Bristow L, Varney M. Reduced stress-induced hyperthermia in mGluR5 knockout mice. Eur J Neurosci. 2002;16:2241-4 pubmed
    It hs been suggested that metabotropic glutamate receptor subtype 5 (mGluR5) play a role in the expression of anxiety, based on anxiolytic-like effects of the selective mGluR5 antagonist MPEP (2-methyl-6-(phenylethynyl)pyridine) in rodent ..
  7. Grueter B, Gosnell H, Olsen C, Schramm Sapyta N, Nekrasova T, Landreth G, et al. Extracellular-signal regulated kinase 1-dependent metabotropic glutamate receptor 5-induced long-term depression in the bed nucleus of the stria terminalis is disrupted by cocaine administration. J Neurosci. 2006;26:3210-9 pubmed
    ..First, a combined activation of group I mGluRs (mGluR1 and mGluR5) induces a transient depression that is cannabinoid 1 receptor dependent...
  8. Eiler W, Baez M, Yu J, Witkin J. mGlu5 receptor deletion reduces relapse to food-seeking and prevents the anti-relapse effects of mGlu5 receptor blockade in mice. Life Sci. 2011;89:862-7 pubmed publisher
    ..The data also reinforce the potential utility of mGlu5 receptor antagonists in relapse prevention to food-seeking behaviors. ..
  9. Jia Z, Lu Y, Henderson J, Taverna F, Romano C, Abramow Newerly W, et al. Selective abolition of the NMDA component of long-term potentiation in mice lacking mGluR5. Learn Mem. 1998;5:331-43 pubmed
    ..To investigate this hypothesis we created mutant mice that expressed no metabotropic glutamate receptor 5 (mGluR5), but showed normal development...
  10. Beraldo F, Arantes C, Santos T, Machado C, Roffe M, Hajj G, et al. Metabotropic glutamate receptors transduce signals for neurite outgrowth after binding of the prion protein to laminin ?1 chain. FASEB J. 2011;25:265-79 pubmed publisher
    ..Expression of either mGluR1 or mGluR5 in HEK293 cells reconstituted the signaling pathways mediated by PrP(C)-Ln ?1 peptide interaction...
  11. Olsen C, Childs D, Stanwood G, Winder D. Operant sensation seeking requires metabotropic glutamate receptor 5 (mGluR5). PLoS ONE. 2010;5:e15085 pubmed publisher
    Pharmacological and genetic studies have suggested that the metabotropic glutamate receptor 5 (mGluR5) is critically involved in mediating the reinforcing effects of drugs of abuse, but not food...
  12. Suvrathan A, Hoeffer C, Wong H, Klann E, Chattarji S. Characterization and reversal of synaptic defects in the amygdala in a mouse model of fragile X syndrome. Proc Natl Acad Sci U S A. 2010;107:11591-6 pubmed publisher
    ..Strikingly, pharmacological inactivation of mGluR5 with 2-methyl-6-phenylethynyl-pyridine (MPEP) fails to rescue either the deficit in long-term potentiation or ..
  13. Stoker A, Olivier B, Markou A. Involvement of metabotropic glutamate receptor 5 in brain reward deficits associated with cocaine and nicotine withdrawal and somatic signs of nicotine withdrawal. Psychopharmacology (Berl). 2012;221:317-27 pubmed publisher
    ..c.) administration via osmotic minipumps in mGlu5 receptor knockout (mGluR5(-/-)) and wild-type (mGluR5(+/+)) mice. Somatic signs were assessed during nicotine withdrawal...
  14. Sun W, McConnell E, Pare J, Xu Q, Chen M, Peng W, et al. Glutamate-dependent neuroglial calcium signaling differs between young and adult brain. Science. 2013;339:197-200 pubmed publisher
    An extensive literature shows that astrocytes exhibit metabotropic glutamate receptor 5 (mGluR5)-dependent increases in cytosolic calcium ions (Ca(2+)) in response to glutamatergic transmission and, in turn, modulate neuronal activity by ..
  15. Huber K, Roder J, Bear M. Chemical induction of mGluR5- and protein synthesis--dependent long-term depression in hippocampal area CA1. J Neurophysiol. 2001;86:321-5 pubmed
    ..DHPG-LTD 1) is a saturable form of synaptic plasticity, 2) requires mGluR5, 3) is mechanistically distinct from N-methyl-D-aspartate receptor (NMDAR)--dependent LTD, and 4) shares a common ..
  16. Dolen G, Osterweil E, Rao B, Smith G, Auerbach B, Chattarji S, et al. Correction of fragile X syndrome in mice. Neuron. 2007;56:955-62 pubmed
    ..According to one proposal, many psychiatric and neurological symptoms of FXS result from unchecked activation of mGluR5, a metabotropic glutamate receptor...
  17. Sidiropoulou K, Lu F, Fowler M, Xiao R, Phillips C, Ozkan E, et al. Dopamine modulates an mGluR5-mediated depolarization underlying prefrontal persistent activity. Nat Neurosci. 2009;12:190-9 pubmed publisher identify a postsynaptic depolarization that was evoked by action potential bursts and mediated by metabotropic glutamate receptor 5 (mGluR5)...
  18. Um J, Kaufman A, Kostylev M, Heiss J, Stagi M, Takahashi H, et al. Metabotropic glutamate receptor 5 is a coreceptor for Alzheimer a? oligomer bound to cellular prion protein. Neuron. 2013;79:887-902 pubmed publisher
    ..Only coexpression of the metabotropic glutamate receptor, mGluR5, allowed PrP(C)-bound A?o to activate Fyn...
  19. Ballester Rosado C, Albright M, Wu C, Liao C, Zhu J, Xu J, et al. mGluR5 in cortical excitatory neurons exerts both cell-autonomous and -nonautonomous influences on cortical somatosensory circuit formation. J Neurosci. 2010;30:16896-909 pubmed publisher
    ..The absence of the group I metabotropic glutamate receptor 5 (mGluR5) leads to abnormal sensory map formation throughout the mouse somatosensory pathway...
  20. She W, Quairiaux C, Albright M, Wang Y, Sanchez D, Chang P, et al. Roles of mGluR5 in synaptic function and plasticity of the mouse thalamocortical pathway. Eur J Neurosci. 2009;29:1379-96 pubmed publisher
    The group I metabotropic glutamate receptor 5 (mGluR5) has been implicated in the development of cortical sensory maps. However, its precise roles in the synaptic function and plasticity of thalamocortical (TC) connections remain unknown...
  21. Lu Y, Jia Z, Janus C, Henderson J, Gerlai R, Wojtowicz J, et al. Mice lacking metabotropic glutamate receptor 5 show impaired learning and reduced CA1 long-term potentiation (LTP) but normal CA3 LTP. J Neurosci. 1997;17:5196-205 pubmed
    ..To test the involvement of one member of this class, we have recently generated mutant mice that express no mGluR5 but normal levels of other glutamate receptors. The CNS revealed normal development of gross anatomical features...
  22. Hays S, Huber K, Gibson J. Altered neocortical rhythmic activity states in Fmr1 KO mice are due to enhanced mGluR5 signaling and involve changes in excitatory circuitry. J Neurosci. 2011;31:14223-34 pubmed publisher
    ..Excess signaling mediated by the group 1 glutamate metabotropic receptor, mGluR5, contributes to the longer UP states...
  23. Osterweil E, Krueger D, Reinhold K, Bear M. Hypersensitivity to mGluR5 and ERK1/2 leads to excessive protein synthesis in the hippocampus of a mouse model of fragile X syndrome. J Neurosci. 2010;30:15616-27 pubmed publisher
    ..According to the metabotropic glutamate receptor (mGluR) theory of FXS, excessive protein synthesis downstream of mGluR5 activation causes the synaptic pathophysiology that underlies multiple aspects of FXS...
  24. Chen C, Lu H, Brumberg J. mGluR5 knockout mice display increased dendritic spine densities. Neurosci Lett. 2012;524:65-8 pubmed publisher
    ..Specifically the metabotropic glutamate receptor 5 (mGluR5) has been implicated in dendrogenesis and spineogenesis, since its activation triggers ..
  25. Arif M, Kazim S, Grundke Iqbal I, Garruto R, Iqbal K. Tau pathology involves protein phosphatase 2A in parkinsonism-dementia of Guam. Proc Natl Acad Sci U S A. 2014;111:1144-9 pubmed publisher
    ..Pretreatment with metabotropic glutamate receptor 5 (mGluR5) and Src antagonists blocked the BMAA-induced inhibition of PP2A and the abnormal ..
  26. Kachroo A, Orlando L, Grandy D, Chen J, Young A, Schwarzschild M. Interactions between metabotropic glutamate 5 and adenosine A2A receptors in normal and parkinsonian mice. J Neurosci. 2005;25:10414-9 pubmed
    ..These data also strengthen a rationale for pursuing a combinational drug strategy for enhancing the antiparkinsonian effects of A2A and mGlu5 antagonists. ..
  27. Mao S, Chang C, Wu C, Orejarena M, Orejanera M, Manzoni O, et al. Inhibition of spontaneous recovery of fear by mGluR5 after prolonged extinction training. PLoS ONE. 2013;8:e59580 pubmed publisher
    ..This effect was specifically blocked by metabotropic glutamate receptor 5 (mGluR5), but not by mGluR1 antagonists and by a protein synthesis inhibitor...
  28. Lee A, Wong R, Chuang S, Shin H, Bianchi R. Role of synaptic metabotropic glutamate receptors in epileptiform discharges in hippocampal slices. J Neurophysiol. 2002;88:1625-33 pubmed
    ..The mGluR1 antagonist (S)-(+)-alpha-amino-4-carboxy-2-methylbenzeneacetic acid (LY 367385; 25-100 microM) and the mGluR5 antagonist 2-methyl-6-(phenylethynyl)pyridine (MPEP; 10-50 microM), applied separately, significantly reduced the ..
  29. Spinsanti P, De Vita T, Di Castro S, Storto M, Formisano P, Nicoletti F, et al. Endogenously activated mGlu5 metabotropic glutamate receptors sustain the increase in c-Myc expression induced by leukaemia inhibitory factor in cultured mouse embryonic stem cells. J Neurochem. 2006;99:299-307 pubmed
  30. Ben Mabrouk F, Amos L, Tryba A. Metabotropic glutamate receptors (mGluR5) activate transient receptor potential canonical channels to improve the regularity of the respiratory rhythm generated by the pre-Bötzinger complex in mice. Eur J Neurosci. 2012;35:1725-37 pubmed publisher
    ..preparations containing the pre-Bötzinger complex (pre-BötC) to identify the role of group I mGluRs (mGluR1 and mGluR5) in respiratory rhythm generation...
  31. Bossi S, Musante I, Bonfiglio T, Bonifacino T, Emionite L, Cerminara M, et al. Genetic inactivation of mGlu5 receptor improves motor coordination in the Grm1crv4 mouse model of SCAR13 ataxia. Neurobiol Dis. 2018;109:44-53 pubmed publisher
    ..GRM1 and GRM5 code for the metabotropic glutamate type 1 (mGlu1) and type 5 (mGlu5) receptors, respectively...
  32. Fang X, Eriksson J, Antoni G, Yngve U, Cato L, Lannfelt L, et al. Brain mGluR5 in mice with amyloid beta pathology studied with in vivo [11C]ABP688 PET imaging and ex vivo immunoblotting. Neuropharmacology. 2017;113:293-300 pubmed publisher
    ..order to convey these neurotoxic effects, Aβo requires interaction with the metabotropic glutamate 5 receptor (mGluR5). The aim was to investigate in vivo mGluR5 changes in an Aβ pathology model using PET...
  33. Mesic I, Guzman Y, Guedea A, Jovasevic V, Corcoran K, Leaderbrand K, et al. Double Dissociation of the Roles of Metabotropic Glutamate Receptor 5 and Oxytocin Receptor in Discrete Social Behaviors. Neuropsychopharmacology. 2015;40:2337-46 pubmed publisher
    ..Here we investigated how Gq-protein-coupled metabotropic glutamate receptor 5 (mGluR5) and oxytocin receptor (Oxtr) affect social affiliation and social memory...
  34. Sidorov M, Kaplan E, Osterweil E, Lindemann L, Bear M. Metabotropic glutamate receptor signaling is required for NMDA receptor-dependent ocular dominance plasticity and LTD in visual cortex. Proc Natl Acad Sci U S A. 2015;112:12852-7 pubmed publisher
    A feature of early postnatal neocortical development is a transient peak in signaling via metabotropic glutamate receptor 5 (mGluR5)...
  35. Wilkerson J, Tsai N, Maksimova M, Wu H, Cabalo N, Loerwald K, et al. A role for dendritic mGluR5-mediated local translation of Arc/Arg3.1 in MEF2-dependent synapse elimination. Cell Rep. 2014;7:1589-1600 pubmed publisher
    ..We report that activation of metabotropic glutamate receptor 5 (mGluR5) on the dendrites, but not cell soma, of hippocampal CA1 neurons is required for MEF2-..
  36. Gogliotti R, Senter R, Rook J, Ghoshal A, Zamorano R, Malosh C, et al. mGlu5 positive allosteric modulation normalizes synaptic plasticity defects and motor phenotypes in a mouse model of Rett syndrome. Hum Mol Genet. 2016;25:1990-2004 pubmed
    ..We report that expression of a key regulator of synaptic protein synthesis, the metabotropic glutamate receptor 5 (mGlu5) protein, is significantly reduced in both the brains of RS model mice and in the ..
  37. Liu B, Dong Q, Zhang S, Su D, Yang Z, Lv M, et al. mGluR1,5 activation protects cortical astrocytes and GABAergic neurons from ischemia-induced impairment. Neurosci Res. 2013;75:160-6 pubmed publisher
    ..The activation of mGluR1,5 is likely a potential therapeutic strategy to prevent nervous tissues from excitotoxicity by reducing the impairment of the astrocytes and GABAergic neurons during the early stage of ischemia. ..
  38. Zhong X, Li H, Chang Q. MeCP2 phosphorylation is required for modulating synaptic scaling through mGluR5. J Neurosci. 2012;32:12841-7 pubmed publisher
    ..synaptic scaling down in mouse hippocampal neurons and this phenotype is mediated by mGluR5 (metabotropic glutamate receptor 5)...
  39. Park J, Hu J, Milshteyn A, Zhang P, Moore C, Park S, et al. A prolyl-isomerase mediates dopamine-dependent plasticity and cocaine motor sensitization. Cell. 2013;154:637-50 pubmed publisher
    ..signaling that is induced by drug administration, the glutamate-receptor protein metabotropic glutamate receptor 5 (mGluR5) is phosphorylated by microtubule-associated protein kinase (MAPK), which we show ..
  40. Heinbockel T, Laaris N, Ennis M. Metabotropic glutamate receptors in the main olfactory bulb drive granule cell-mediated inhibition. J Neurophysiol. 2007;97:858-70 pubmed
    ..bulb (MOB) granule cells (GCs) express high levels of the group I metabotropic glutamate receptor (mGluR), mGluR5. We investigated the role of mGluRs in regulating GC activity in rodent MOB slices using whole cell patch-clamp ..
  41. Tan S, Ganella D, Dick A, Duncan J, Ong Palsson E, Bathgate R, et al. Spatial Learning Requires mGlu5 Signalling in the Dorsal Hippocampus. Neurochem Res. 2015;40:1303-10 pubmed publisher
    We examined the role of hippocampal metabotropic glutamate receptor 5 (mGlu5) in spatial learning and memory...
  42. Ferreira L, Dale L, Ribeiro F, Babwah A, Pampillo M, Ferguson S. Calcineurin inhibitor protein (CAIN) attenuates Group I metabotropic glutamate receptor endocytosis and signaling. J Biol Chem. 2009;284:28986-94 pubmed publisher
    ..We show here that both mGluR1 and mGluR5 interact with the calcineurin inhibitor protein (CAIN)...
  43. Balu D, Li Y, Takagi S, Presti K, Ramikie T, Rook J, et al. An mGlu5-Positive Allosteric Modulator Rescues the Neuroplasticity Deficits in a Genetic Model of NMDA Receptor Hypofunction in Schizophrenia. Neuropsychopharmacology. 2016;41:2052-61 pubmed publisher
    ..b>Metabotropic glutamate receptor 5 (mGlu5)-positive allosteric modulators (PAMs) are currently being developed to treat cognitive ..
  44. Ballester Rosado C, Sun H, Huang J, Lu H. mGluR5 Exerts Cell-Autonomous Influences on the Functional and Anatomical Development of Layer IV Cortical Neurons in the Mouse Primary Somatosensory Cortex. J Neurosci. 2016;36:8802-14 pubmed publisher
    ..Deleting metabotropic glutamate receptor 5 (mGluR5) in mice perturbs cortical somatosensory map formation in the primary somatosensory (S1) ..
  45. Xiao W, Feng Y, Holst J, Hartmann B, Yang H, Teitelbaum D. Glutamate prevents intestinal atrophy via luminal nutrient sensing in a mouse model of total parenteral nutrition. FASEB J. 2014;28:2073-87 pubmed publisher IEC proliferation) and was dependent on up-regulation of the protein kinase pAkt, but independent of T1R3 and mGluR5 signaling...
  46. Cannella M, Motolese M, Bucci D, Molinaro G, Gradini R, Bruno V, et al. Changes in the expression of genes encoding for mGlu4 and mGlu5 receptors and other regulators of the indirect pathway in acute mouse models of drug-induced parkinsonism. Neuropharmacology. 2015;95:50-8 pubmed publisher
  47. Xu J, Antion M, Nomura T, Kraniotis S, Zhu Y, Contractor A. Hippocampal metaplasticity is required for the formation of temporal associative memories. J Neurosci. 2014;34:16762-73 pubmed publisher
    ..Conditional ablation of mGluR5 in CA1 pyramidal neurons resulted in the inability of low-frequency trains of afferent activation to prime ..
  48. Stoppel L, Auerbach B, Senter R, Preza A, Lefkowitz R, Bear M. β-Arrestin2 Couples Metabotropic Glutamate Receptor 5 to Neuronal Protein Synthesis and Is a Potential Target to Treat Fragile X. Cell Rep. 2017;18:2807-2814 pubmed publisher
    ..Neural activity directs local protein synthesis via activation of metabotropic glutamate receptor 5 (mGlu5), yet how mGlu5 couples to the intracellular signaling pathways that ..
  49. Thomas A, Bui N, Graham D, Perkins J, Yuva Paylor L, Paylor R. Genetic reduction of group 1 metabotropic glutamate receptors alters select behaviors in a mouse model for fragile X syndrome. Behav Brain Res. 2011;223:310-21 pubmed publisher
    ..signaling through group I metabotropic glutamate receptors (Gp1 mGluRs), comprised of subtypes mGluR1 and mGluR5, may play a role. Hence, Gp1 mGluRs may act as modifiers of FXS...
  50. Wilson B, Cox C. Absence of metabotropic glutamate receptor-mediated plasticity in the neocortex of fragile X mice. Proc Natl Acad Sci U S A. 2007;104:2454-9 pubmed
    ..The selective mGluR5 antagonist 2-methyl-6-(phenylethynyl)-pyridine (MPEP) attenuated LTP to a similar degree as did MCPG in wild-type ..
  51. Takasaki C, Okada R, Mitani A, Fukaya M, Yamasaki M, Fujihara Y, et al. Glutamate transporters regulate lesion-induced plasticity in the developing somatosensory cortex. J Neurosci. 2008;28:4995-5006 pubmed publisher
    ..Considering an essential role of glutamate receptors in the formation of whisker-related thalamocortical synapse patterning, glutamate transporters thus facilitate their activity-dependent remodeling. ..
  52. Gregg L, Jung K, Spradley J, Nyilas R, Suplita R, Zimmer A, et al. Activation of type 5 metabotropic glutamate receptors and diacylglycerol lipase-? initiates 2-arachidonoylglycerol formation and endocannabinoid-mediated analgesia. J Neurosci. 2012;32:9457-68 pubmed publisher
    ..The results indicate that activation of the postsynaptic mGlu(5)-DGL-? cascade triggers retrograde 2-AG signaling in vivo. This pathway is required for endocannabinoid-mediated stress-induced analgesia. ..
  53. O Riordan K, Gerstein H, Hullinger R, Burger C. The role of Homer1c in metabotropic glutamate receptor-dependent long-term potentiation. Hippocampus. 2014;24:1-6 pubmed publisher
    ..This form of synaptic plasticity was dependent on mGluR5 but not mGluR1 activation both in wild-type mice and in KO+H1c...
  54. Al Sweidi S, Morissette M, Di Paolo T. Estrogen receptors modulate striatal metabotropic receptor type 5 in intact and MPTP male mice model of Parkinson's disease. J Steroid Biochem Mol Biol. 2016;161:84-91 pubmed publisher
    ..These results thus show that in male mice ERs affect striatal mGlu5 receptor levels and their response to MPTP. ..
  55. Provenzano G, Sgadò P, Genovesi S, Zunino G, Casarosa S, Bozzi Y. Hippocampal dysregulation of FMRP/mGluR5 signaling in engrailed-2 knockout mice: a model of autism spectrum disorders. Neuroreport. 2015;26:1101-5 pubmed publisher
    ..Dysfunctions in fragile X mental retardation protein (FMRP), metabotropic glutamate receptor 5 (mGluR5), and GABAergic signaling pathways have been proposed as a possible pathogenic mechanism of ..
  56. Price T, Rashid M, Millecamps M, Sanoja R, Entrena J, Cervero F. Decreased nociceptive sensitization in mice lacking the fragile X mental retardation protein: role of mGluR1/5 and mTOR. J Neurosci. 2007;27:13958-67 pubmed
    ..deficits are related to a mGluR1/5- and mammalian target of rapamycin (mTOR)-mediated mechanism because (1) spinal mGluR5 antagonism failed to inhibit the second phase of the formalin test, and we observed a marked reduction in ..
  57. Gass J, Olive M. Transcriptional profiling of the rat frontal cortex following administration of the mGlu5 receptor antagonists MPEP and MTEP. Eur J Pharmacol. 2008;584:253-62 pubmed publisher
  58. Fowler S, Walker J, Klakotskaia D, Will M, Serfozo P, Simonyi A, et al. Effects of a metabotropic glutamate receptor 5 positive allosteric modulator, CDPPB, on spatial learning task performance in rodents. Neurobiol Learn Mem. 2013;99:25-31 pubmed publisher
    b>Metabotropic glutamate receptor 5 (mGlu5) has been implicated in a variety of learning and memory processes and is important for avoidance learning...
  59. Beard R, Reynolds J, Bearden S. Metabotropic glutamate receptor 5 mediates phosphorylation of vascular endothelial cadherin and nuclear localization of ?-catenin in response to homocysteine. Vascul Pharmacol. 2012;56:159-67 pubmed publisher
    ..This was blocked by inhibition of either metabotropic glutamate receptor 5 (mGluR5) or ionotropic glutamate receptor (NMDAr) and by shRNA knockdown of mGluR5...
  60. Moriguchi S, Han F, Shioda N, Yamamoto Y, Nakajima T, Nakagawasai O, et al. Nefiracetam activation of CaM kinase II and protein kinase C mediated by NMDA and metabotropic glutamate receptors in olfactory bulbectomized mice. J Neurochem. 2009;110:170-81 pubmed publisher
    ..with 2-methyl-6-(phenylethynyl)-pyridine, but not by treatment with LY367385, suggesting that metabotropic glutamate receptor 5 (mGluR5) but not mGluR1 is involved in the nefiracetam-induced LTP enhancement...
  61. de Esch C, van den Berg W, Buijsen R, Jaafar I, Nieuwenhuizen Bakker I, Gasparini F, et al. Fragile X mice have robust mGluR5-dependent alterations of social behaviour in the Automated Tube Test. Neurobiol Dis. 2015;75:31-9 pubmed publisher
    ..albeit partial, rescue of the altered social behaviour of Fmr1 knockout mice in the ATT, using genetic (mGluR5 deletion) or pharmacological inhibition (mGluR5 antagonist) of mGluR5 signalling independently...
  62. Higashimori H, Morel L, Huth J, Lindemann L, Dulla C, Taylor A, et al. Astroglial FMRP-dependent translational down-regulation of mGluR5 underlies glutamate transporter GLT1 dysregulation in the fragile X mouse. Hum Mol Genet. 2013;22:2041-54 pubmed publisher
    ..protein (but not mRNA) expression and the (S)-3,5-dihydroxyphenylglycine-dependent Ca(2+) responses of astroglial mGluR5 receptor are also selectively reduced in fmr1(-/-) astrocytes and brain slices, attenuating neuron-dependent GLT1 ..
  63. Ade K, Wan Y, Hamann H, O Hare J, Guo W, Quian A, et al. Increased Metabotropic Glutamate Receptor 5 Signaling Underlies Obsessive-Compulsive Disorder-like Behavioral and Striatal Circuit Abnormalities in Mice. Biol Psychiatry. 2016;80:522-33 pubmed publisher
    ..Sapap3 knockout (KO) mice treated acutely with an mGluR5 antagonist were evaluated for OCD-relevant phenotypes of self-grooming, anxiety-like behaviors, and increased ..
  64. Salisbury B, Mukhopadhyay G, Kostich M, Laz T, Norris E. Inducible expression and pharmacological characterization of the mouse metabotropic glutamate 5b receptor. Eur J Pharmacol. 2008;579:34-9 pubmed
    ..8-66 nM). The availability of this mouse mGlu5b receptor-expressing cell line will facilitate in vitro characterization of mGlu5 receptor-selective agonists or antagonists prior to in vivo pharmacologic testing. ..
  65. Grueter B, McElligott Z, ROBISON A, Mathews G, Winder D. In vivo metabotropic glutamate receptor 5 (mGluR5) antagonism prevents cocaine-induced disruption of postsynaptically maintained mGluR5-dependent long-term depression. J Neurosci. 2008;28:9261-70 pubmed publisher
    b>Metabotropic glutamate receptor 5 (mGluR5) plays a critical role in psychostimulant-induced behavior, yet it is unclear whether mGluR5 is activated by psychostimulant administration, or whether its role is constitutive...
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    ..such critical phases of cell development in other systems through specific receptors such as metabotropic glutamate receptor 5 (mGlu(5)R)...
  67. Guimaraes I, Carvalho T, Ferguson S, Pereira G, Ribeiro F. The metabotropic glutamate receptor 5 role on motor behavior involves specific neural substrates. Mol Brain. 2015;8:24 pubmed publisher
    The metabotropic glutamate receptor 5 (mGluR5) is involved in various brain functions, including memory, cognition and motor behavior...
  68. Wang H, Warner Schmidt J, Varela S, Enikolopov G, Greengard P, Flajolet M. Norbin ablation results in defective adult hippocampal neurogenesis and depressive-like behavior in mice. Proc Natl Acad Sci U S A. 2015;112:9745-50 pubmed publisher
    ..Of the eight metabotropic glutamate receptors (mGluRs), mGluR5 is the most highly expressed in neural stem cells...
  69. Karl T, Burne T, van den Buuse M, Chesworth R. Do transmembrane domain neuregulin 1 mutant mice exhibit a reliable sensorimotor gating deficit?. Behav Brain Res. 2011;223:336-41 pubmed publisher
    ..The research suggests that analysing one of the alleged hallmarks of animal models for schizophrenia must be done carefully: to obtain reliable PPI data it seems necessary to use more than one particular PPI protocol. ..
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    The G-protein coupled receptor, metabotropic glutamate receptor 5 (mGluR5), is expressed on both cell surface and intracellular membranes in striatal neurons...
  71. Dvorzhak A, Semtner M, Faber D, Grantyn R. Tonic mGluR5/CB1-dependent suppression of inhibition as a pathophysiological hallmark in the striatum of mice carrying a mutant form of huntingtin. J Physiol. 2013;591:1145-66 pubmed publisher
    ..Pharmacological tests identified the HD-related tonic suppression of synaptic inhibition as a glutamate- and endocannabinoid-dependent process. ..
  72. Bird M, Lohmann P, West B, Brown R, Kirchhoff J, Raymond C, et al. The mGlu5 receptor regulates extinction of cocaine-driven behaviours. Drug Alcohol Depend. 2014;137:83-9 pubmed publisher
    ..Collectively, these findings suggest that while the mGlu5 receptor may be involved in mediating the rewarding effects of cocaine, it appears necessary for the extinction of cocaine-driven behaviours. ..
  73. Akgün E, Javed M, Lunzer M, Smeester B, Beitz A, Portoghese P. Ligands that interact with putative MOR-mGluR5 heteromer in mice with inflammatory pain produce potent antinociception. Proc Natl Acad Sci U S A. 2013;110:11595-9 pubmed publisher
    ..In this regard, the use of opioids with metabotropic glutamate-5 receptor (mGluR5) antagonist has been reported to increase the efficacy of morphine and prevent the establishment of adverse ..
  74. Pizzi M, Sarnico I, Boroni F, Benarese M, Steimberg N, Mazzoleni G, et al. NF-kappaB factor c-Rel mediates neuroprotection elicited by mGlu5 receptor agonists against amyloid beta-peptide toxicity. Cell Death Differ. 2005;12:761-72 pubmed
    ..These data demonstrate that mGlu5 receptor activation promotes a c-Rel-dependent antiapoptotic pathway responsible for neuroprotection against Abeta peptide. ..
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    ..We herein report that calmodulin (CaM) interacts with the metabotropic glutamate receptor subtype 5 (mGluR5) in a Ca2+-dependent manner in vitro...
  76. Jong Y, Kumar V, O Malley K. Intracellular metabotropic glutamate receptor 5 (mGluR5) activates signaling cascades distinct from cell surface counterparts. J Biol Chem. 2009;284:35827-38 pubmed publisher
    ..Some receptors, including the metabotropic glutamate receptor 5 (mGluR5), are also highly expressed on intracellular membranes where they serve unknown functions...
  77. Le Vasseur M, Ran I, Lacaille J. Selective induction of metabotropic glutamate receptor 1- and metabotropic glutamate receptor 5-dependent chemical long-term potentiation at oriens/alveus interneuron synapses of mouse hippocampus. Neuroscience. 2008;151:28-42 pubmed
    ..However these interneurons also express mGluR5 and the contribution of this receptor subtype in interneuron synaptic plasticity remains unexplored...
  78. Narita M, Suzuki M, Narita M, Niikura K, Nakamura A, Miyatake M, et al. Involvement of spinal metabotropic glutamate receptor 5 in the development of tolerance to morphine-induced antinociception. J Neurochem. 2005;94:1297-305 pubmed
    ..t.) or subcutaneous (s.c.) injection of the selective metabotropic glutamate receptor 5 (mGluR5) antagonist, methyl-6-(phenylethynyl)-pyridine hydrochloride (MPEP), attenuated the ..