Gene Symbol: Grm1
Description: glutamate receptor, metabotropic 1
Alias: 4930455H15Rik, Gm10828, Gprc1a, mGluR1, nmf373, rcw, wobl, metabotropic glutamate receptor 1, G protein-coupled receptor, family C, group 1, member A
Species: mouse
Products:     Grm1

Top Publications

  1. Battaglia G, Busceti C, Molinaro G, Biagioni F, Storto M, Fornai F, et al. Endogenous activation of mGlu5 metabotropic glutamate receptors contributes to the development of nigro-striatal damage induced by 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine in mice. J Neurosci. 2004;24:828-35 pubmed
    ..We conclude that mGlu5 receptors act as amplifiers of MPTP toxicity and that mGlu5 receptor antagonists may limit the extent of nigro-striatal damage in experimental models of parkinsonism. ..
  2. Hou L, Klann E. Activation of the phosphoinositide 3-kinase-Akt-mammalian target of rapamycin signaling pathway is required for metabotropic glutamate receptor-dependent long-term depression. J Neurosci. 2004;24:6352-61 pubmed
    ..Together, our findings indicate that activation of the PI3K-Akt-mTOR signaling cascade is required for mGluR-LTD and suggest that this pathway may couple group I mGluRs to translation initiation in hippocampal area CA1. ..
  3. Fogal B, Li J, Lobner D, McCullough L, Hewett S. System x(c)- activity and astrocytes are necessary for interleukin-1 beta-mediated hypoxic neuronal injury. J Neurosci. 2007;27:10094-105 pubmed
    ..Indeed, dual System x(c)-/metabotropic glutamate receptor subunit 1 (mGluR1) antagonism but not selective mGluR1 antagonism prevented neuronal injury...
  4. Gil Sanz C, Delgado Garcia J, Fairen A, Gruart A. Involvement of the mGluR1 receptor in hippocampal synaptic plasticity and associative learning in behaving mice. Cereb Cortex. 2008;18:1653-63 pubmed
    b>Metabotropic glutamate receptor 1 (mGluR1) has been related to processes underlying learning in hippocampal circuits, but demonstrating its involvement in synaptic plasticity when measured directly on the relevant circuit of a learning ..
  5. Mameli M, Halbout B, Creton C, Engblom D, Parkitna J, Spanagel R, et al. Cocaine-evoked synaptic plasticity: persistence in the VTA triggers adaptations in the NAc. Nat Neurosci. 2009;12:1036-41 pubmed publisher
    ..drug relapse in mice and found that the duration of the cocaine-evoked synaptic plasticity in the VTA is gated by mGluR1. Overriding mGluR1 in vivo made the potentiation in the VTA persistent...
  6. Chen S, Zhu H, Wetzel W, Philbert M. Spontaneous melanocytosis in transgenic mice. J Invest Dermatol. 1996;106:1145-51 pubmed
    ..This line of transgenic mice may provide a useful model for investigation of the etiology and progression of benign and malignant melanin-containing tumors. ..
  7. Kumari R, Castillo C, Francesconi A. Agonist-dependent signaling by group I metabotropic glutamate receptors is regulated by association with lipid domains. J Biol Chem. 2013;288:32004-19 pubmed publisher
    Group I metabotropic glutamate receptors (mGluRs), mGluR1 and mGluR5, play critical functions in forms of activity-dependent synaptic plasticity and synapse remodeling in physiological and pathological states...
  8. Maejima T, Oka S, Hashimotodani Y, Ohno Shosaku T, Aiba A, Wu D, et al. Synaptically driven endocannabinoid release requires Ca2+-assisted metabotropic glutamate receptor subtype 1 to phospholipase Cbeta4 signaling cascade in the cerebellum. J Neurosci. 2005;25:6826-35 pubmed
    ..The first mode is strong activation of mGluR subtype 1 (mGluR1)-phospholipase C (PLC) beta4 cascade without detectable Ca2+ elevation...
  9. Brakeman P, Lanahan A, O Brien R, Roche K, Barnes C, Huganir R, et al. Homer: a protein that selectively binds metabotropic glutamate receptors. Nature. 1997;386:284-8 pubmed
    ..This dynamic transcriptional control suggests that Homer mediates a novel cellular mechanism that regulates metabotropic glutamate signalling. ..

More Information


  1. Volk L, Daly C, Huber K. Differential roles for group 1 mGluR subtypes in induction and expression of chemically induced hippocampal long-term depression. J Neurophysiol. 2006;95:2427-38 pubmed
    Although metabotropic glutamate receptors (mGluRs) mGluR1 and mGluR5 are often found to have similar functions, there is considerable evidence that the two receptors also serve distinct functions in neurons...
  2. Hildebrand M, Isope P, Miyazaki T, Nakaya T, Garcia E, Feltz A, et al. Functional coupling between mGluR1 and Cav3.1 T-type calcium channels contributes to parallel fiber-induced fast calcium signaling within Purkinje cell dendritic spines. J Neurosci. 2009;29:9668-82 pubmed publisher
    ..We combine electrophysiological and ultrafast two-photon calcium imaging to demonstrate that mGluR1 activation potentiates cerebellar Purkinje cell Ca(v)3...
  3. Xiao B, Tu J, Petralia R, Yuan J, Doan A, Breder C, et al. Homer regulates the association of group 1 metabotropic glutamate receptors with multivalent complexes of homer-related, synaptic proteins. Neuron. 1998;21:707-16 pubmed
    ..These observations support a model in which the dynamic expression of Homer 1a competes with constitutively expressed CC-Homers to modify synaptic mGluR properties. ..
  4. Moriyoshi K, Iijima K, Fujii H, Ito H, Cho Y, Nakanishi S. Seven in absentia homolog 1A mediates ubiquitination and degradation of group 1 metabotropic glutamate receptors. Proc Natl Acad Sci U S A. 2004;101:8614-9 pubmed
  5. Pollock P, Cohen Solal K, Sood R, Namkoong J, Martino J, Koganti A, et al. Melanoma mouse model implicates metabotropic glutamate signaling in melanocytic neoplasia. Nat Genet. 2003;34:108-12 pubmed
    ..mapping identified multiple tandem insertions of the transgene into intron 3 of Grm1 (encoding metabotropic glutamate receptor 1) with concomitant deletion of 70 kb of intronic sequence...
  6. Nunzi M, Shigemoto R, Mugnaini E. Differential expression of calretinin and metabotropic glutamate receptor mGluR1alpha defines subsets of unipolar brush cells in mouse cerebellum. J Comp Neurol. 2002;451:189-99 pubmed
    ..The different distribution patterns of the two UBC subsets within lobule X suggest that expression of CR or mGluR1alpha by UBCs may be afferent-specific and related to the terminal fields of different vestibular MF afferents. ..
  7. Francesconi A, Kumari R, Zukin R. Regulation of group I metabotropic glutamate receptor trafficking and signaling by the caveolar/lipid raft pathway. J Neurosci. 2009;29:3590-602 pubmed publisher
    ..rafts and the main coat protein of caveolae, binds to and colocalizes with metabotropic glutamate receptors 1/5 (mGluR1/5)...
  8. Zhang F, Liu B, Lei Z, Wang J. mGluR?,5 activation improves network asynchrony and GABAergic synapse attenuation in the amygdala: implication for anxiety-like behavior in DBA/2 mice. Mol Brain. 2012;5:20 pubmed publisher
    ..b>mGluR1,5 activation improves the anxiety-like behaviors of DBA/2 mice, synchronizes the activity of amygdala neurons and ..
  9. Lu Y, Jia Z, Janus C, Henderson J, Gerlai R, Wojtowicz J, et al. Mice lacking metabotropic glutamate receptor 5 show impaired learning and reduced CA1 long-term potentiation (LTP) but normal CA3 LTP. J Neurosci. 1997;17:5196-205 pubmed
    ..This is consistent with the hypothesis that LTP in the CA1 region may underlie spatial learning and memory. ..
  10. Wang H, Wu L, Zhang F, Zhuo M. Roles of calcium-stimulated adenylyl cyclase and calmodulin-dependent protein kinase IV in the regulation of FMRP by group I metabotropic glutamate receptors. J Neurosci. 2008;28:4385-97 pubmed publisher
    ..Our study has provided the first evidence for a molecular link between group I mGluRs and FMRP in ACC neurons and may help us to understand the pathogenesis of fragile X syndrome. ..
  11. MARIN Y, Namkoong J, Cohen Solal K, Shin S, Martino J, Oka M, et al. Stimulation of oncogenic metabotropic glutamate receptor 1 in melanoma cells activates ERK1/2 via PKCepsilon. Cell Signal. 2006;18:1279-86 pubmed
    b>Metabotropic glutamate receptor 1 (Grm1, formerly mGluR1) is a G protein coupled receptor (GPCR) normally expressed and functional in the central nervous system...
  12. Aiba A, Kano M, Chen C, Stanton M, Fox G, Herrup K, et al. Deficient cerebellar long-term depression and impaired motor learning in mGluR1 mutant mice. Cell. 1994;79:377-88 pubmed
    b>mGluR1 mutant mice are viable but show characteristic cerebellar symptoms such as ataxic gait and intention tremor. The anatomy of the cerebellum is not overtly disturbed...
  13. Colón Teicher L, Wise L, Martino J, Baskin L, Sakoulas G, Pollack R, et al. Genomic sequences capable of committing mouse and rat fibroblasts to adipogenesis. Nucleic Acids Res. 1993;21:2223-8 pubmed
    ..We conclude that commitment to adipogenesis can be effected in vitro with high efficiency by transfection of specific sequences into a variety of host cells. ..
  14. Iwagaki N, Miles G. Activation of group I metabotropic glutamate receptors modulates locomotor-related motoneuron output in mice. J Neurophysiol. 2011;105:2108-20 pubmed publisher
    ..Given that group I mGluR activation reduces motoneuron excitability, mGluRs may provide negative feedback control of motoneuron output, particularly during high levels of glutamatergic stimulation. ..
  15. Narushima M, Uchigashima M, Yagasaki Y, Harada T, Nagumo Y, Uesaka N, et al. The Metabotropic Glutamate Receptor Subtype 1 Mediates Experience-Dependent Maintenance of Mature Synaptic Connectivity in the Visual Thalamus. Neuron. 2016;91:1097-1109 pubmed publisher
    ..Here we report that the metabotropic glutamate receptor subtype 1 (mGluR1) is essential for the maintenance of mature synaptic connectivity in the dorsal lateral geniculate nucleus (dLGN)...
  16. de Jel M, Engelmann J, Kunz M, Schiffner S, Kuphal S, Bosserhoff A. Transcriptome sequencing of melanocytic nevi and melanomas from Grm1 transgenic mice to determine melanoma driver mutations. Pigment Cell Melanoma Res. 2014;27:678-80 pubmed publisher
  17. Lapointe V, Morin F, Ratté S, Croce A, Conquet F, Lacaille J. Synapse-specific mGluR1-dependent long-term potentiation in interneurones regulates mouse hippocampal inhibition. J Physiol. 2004;555:125-35 pubmed
    ..LTP induction was absent in metabotropic glutamate receptor 1 (mGluR1) knockout mice, was correlated with the postsynaptic presence of mGluR1a, and required a ..
  18. Brody S, Conquet F, Geyer M. Disruption of prepulse inhibition in mice lacking mGluR1. Eur J Neurosci. 2003;18:3361-6 pubmed
    ..Group I consists of mGluR5 and mGluR1, both of which are coupled positively to phospholipase C. Mice lacking mGluR5 exhibit a deficit in PPI...
  19. Milanese M, Giribaldi F, Melone M, Bonifacino T, Musante I, Carminati E, et al. Knocking down metabotropic glutamate receptor 1 improves survival and disease progression in the SOD1(G93A) mouse model of amyotrophic lateral sclerosis. Neurobiol Dis. 2014;64:48-59 pubmed publisher
    ..that the activation of Group I metabotropic Glu autoreceptors, belonging to both type 1 and type 5 receptors (mGluR1 and mGluR5), at glutamatergic spinal cord nerve terminals, produces excessive Glu release in mice over-expressing ..
  20. Pisani A, Gubellini P, Bonsi P, Conquet F, Picconi B, Centonze D, et al. Metabotropic glutamate receptor 5 mediates the potentiation of N-methyl-D-aspartate responses in medium spiny striatal neurons. Neuroscience. 2001;106:579-87 pubmed
    ..Likewise, in mGluR1 knockout mice, both 3,5-DHPG and CHPG were able to potentiate NMDA responses...
  21. Ohtani Y, Miyata M, Hashimoto K, Tabata T, Kishimoto Y, Fukaya M, et al. The synaptic targeting of mGluR1 by its carboxyl-terminal domain is crucial for cerebellar function. J Neurosci. 2014;34:2702-12 pubmed publisher
    The metabotropic glutamate receptor subtype 1 (mGluR1, Grm1) in cerebellar Purkinje cells (PCs) is essential for motor coordination and motor learning...
  22. Meera P, Pulst S, Otis T. A positive feedback loop linking enhanced mGluR function and basal calcium in spinocerebellar ataxia type 2. elife. 2017;6: pubmed publisher
    b>Metabotropic glutamate receptor 1 (mGluR1) function in Purkinje neurons (PNs) is essential for cerebellar development and for motor learning and altered mGluR1 signaling causes ataxia...
  23. Ryo Y, Miyawaki A, Furuichi T, Mikoshiba K. Expression of the metabotropic glutamate receptor mGluR1 alpha and the ionotropic glutamate receptor GluR1 in the brain during the postnatal development of normal mouse and in the cerebellum from mutant mice. J Neurosci Res. 1993;36:19-32 pubmed
    Expression of the metabotropic glutamate receptor type 1 alpha (mGluR1 alpha) and the non-N-methyl-D-aspartate (NMDA) ionotropic glutamate receptor type 1 (GluR1) in mouse brain was investigated using the antibodies raised against the ..
  24. Kato A, Knierman M, Siuda E, Isaac J, Nisenbaum E, Bredt D. Glutamate receptor ?2 associates with metabotropic glutamate receptor 1 (mGluR1), protein kinase C?, and canonical transient receptor potential 3 and regulates mGluR1-mediated synaptic transmission in cerebellar Purkinje neurons. J Neurosci. 2012;32:15296-308 pubmed publisher
    Cerebellar motor coordination and cerebellar Purkinje cell synaptic function require metabotropic glutamate receptor 1 (mGluR1, Grm1)...
  25. Maltecca F, Baseggio E, Consolato F, Mazza D, Podini P, Young S, et al. Purkinje neuron Ca2+ influx reduction rescues ataxia in SCA28 model. J Clin Invest. 2015;125:263-74 pubmed publisher
    ..In SCA28 mice, partial genetic silencing of the metabotropic glutamate receptor mGluR1 decreased Ca²⁺ influx in PCs and reversed the ataxic phenotype...
  26. Bellone C, Mameli M, Lüscher C. In utero exposure to cocaine delays postnatal synaptic maturation of glutamatergic transmission in the VTA. Nat Neurosci. 2011;14:1439-46 pubmed publisher
    ..Subsequently, mGluR1 receptors drove synaptic insertion of calcium-impermeable AMPA receptors and GluN2A-containing NMDAR...
  27. Stoop R, Conquet F, Pralong E. Determination of group I metabotropic glutamate receptor subtypes involved in the frequency of epileptiform activity in vitro using mGluR1 and mGluR5 mutant mice. Neuropharmacology. 2003;44:157-62 pubmed
    ..In slices of subtype I mGluR1 or subtype I mGluR5 knockout mice, bicuculline elicited spontaneous epileptiform bursts with similar duration and ..
  28. Schiffner S, Chen S, Becker J, Bosserhoff A. Highly pigmented Tg(Grm1) mouse melanoma develops non-pigmented melanoma cells in distant metastases. Exp Dermatol. 2012;21:786-8 pubmed publisher
    ..The Tg(Grm1)EPv melanoma mouse model is characterized by spontaneous development of pigmented cutaneous melanomas at hairless ..
  29. Nakao H, Nakao K, Kano M, Aiba A. Metabotropic glutamate receptor subtype-1 is essential for motor coordination in the adult cerebellum. Neurosci Res. 2007;57:538-43 pubmed
    We previously demonstrated that metabotropic glutamate receptor-subtype 1 knockout [mGluR1 (-/-)] mice showed ataxic gait, deficient long-term depression and impaired synapse elimination and these phenotypes were rescued by introduction ..
  30. Cui Q, Pitt J, Pamukcu A, Poulin J, Mabrouk O, Fiske M, et al. Blunted mGluR Activation Disinhibits Striatopallidal Transmission in Parkinsonian Mice. Cell Rep. 2016;17:2431-2444 pubmed publisher
    ..These findings argue that astrocytes are key regulators of the striatopallidal synapse. Targeting this cell class may serve as an alternative therapeutic strategy for PD. ..
  31. Chanda S, Xu Friedman M. Excitatory modulation in the cochlear nucleus through group I metabotropic glutamate receptor activation. J Neurosci. 2011;31:7450-5 pubmed publisher
    ..Thus, interaction between these two modulatory pathways may provide additional flexibility for fine-tuning the BC relay. ..
  32. Pitsch J, Schoch S, Gueler N, Flor P, van Der Putten H, Becker A. Functional role of mGluR1 and mGluR4 in pilocarpine-induced temporal lobe epilepsy. Neurobiol Dis. 2007;26:623-33 pubmed
    ..b>mGluR1 mediates predominantly excitatory effects, whereas mGluR4 acts as inhibitory presynaptic receptor...
  33. De Saint Jan D, Westbrook G. Disynaptic amplification of metabotropic glutamate receptor 1 responses in the olfactory bulb. J Neurosci. 2007;27:132-40 pubmed
    ..The slow EPSP appeared at postnatal days 10-11 and was mediated by metabotropic glutamate receptor 1 (mGluR1) and NMDA receptors...
  34. Gulia R, Sharma R, Bhattacharyya S. A Critical Role for Ubiquitination in the Endocytosis of Glutamate Receptors. J Biol Chem. 2017;292:1426-1437 pubmed publisher
    ..A lysine residue (Lys1112) at the C-terminal tail of mGluR1 (a member of the group I mGluR family) plays crucial role in this process...
  35. Boulware M, Heisler J, Frick K. The memory-enhancing effects of hippocampal estrogen receptor activation involve metabotropic glutamate receptor signaling. J Neurosci. 2013;33:15184-94 pubmed publisher
    ..Finally, we show that ER?, ER?, mGluR1, and ERK all reside within specialized membrane microdomains of the DH, and that ER? and ER? physically interact ..
  36. Kubota H, Nagao S, Obata K, Hirono M. mGluR1-mediated excitation of cerebellar GABAergic interneurons requires both G protein-dependent and Src-ERK1/2-dependent signaling pathways. PLoS ONE. 2014;9:e106316 pubmed publisher
    Stimulation of type I metabotropic glutamate receptors (mGluR1/5) in several neuronal types induces slow excitatory responses through activation of transient receptor potential canonical (TRPC) channels...
  37. Hou P, Liu Z, Li N, Cheng W, Guo S. Knockdown of STIM1 improves neuronal survival after traumatic neuronal injury through regulating mGluR1-dependent Ca(2+) signaling in mouse cortical neurons. Cell Mol Neurobiol. 2015;35:283-92 pubmed publisher
    ..Here, we investigated the role of STIM1 in regulating metabotropic glutamate receptor 1 (mGluR1)-related Ca(2+) signaling and neuronal survival by using an in vitro traumatic neuronal ..
  38. Alioto T, Ngai J. The repertoire of olfactory C family G protein-coupled receptors in zebrafish: candidate chemosensory receptors for amino acids. BMC Genomics. 2006;7:309 pubmed
  39. Daniel H, Levenes C, Fagni L, Conquet F, Bockaert J, Crepel F. Inositol-1,4,5-trisphosphate-mediated rescue of cerebellar long-term depression in subtype 1 metabotropic glutamate receptor mutant mouse. Neuroscience. 1999;92:1-6 pubmed
    ..glutamate receptors, since long-term depression is impaired in subtype 1 metabotropic glutamate receptor (mGluR1) knockout mice...
  40. Aiba A, Chen C, Herrup K, Rosenmund C, Stevens C, Tonegawa S. Reduced hippocampal long-term potentiation and context-specific deficit in associative learning in mGluR1 mutant mice. Cell. 1994;79:365-75 pubmed
    We generated a novel strain of mutant mouse with a deletion in the gene encoding metabotropic glutamate receptor 1 (mGluR1)...
  41. Tabata T, Aiba A, Kano M. Extracellular calcium controls the dynamic range of neuronal metabotropic glutamate receptor responses. Mol Cell Neurosci. 2002;20:56-68 pubmed
    ..Purkinje cells (PCs), Ca2+(o) drastically broadened the effective dose range for glutamate analogs in which native mGluR1-mediated cation current and intracellular Ca2+ mobilization were evoked...
  42. Liberatore F, Bucci D, Mascio G, Madonna M, Di Pietro P, Beneventano M, et al. Permissive role for mGlu1 metabotropic glutamate receptors in excitotoxic retinal degeneration. Neuroscience. 2017;363:142-149 pubmed publisher
    ..These findings demonstrate that mGlu1 receptors play a key role in excitotoxic degeneration of RGCs, and encourage the study of mGlu1 receptor NAMs in models of retinal neurodegeneration. ..
  43. Feng W, Simoes de Souza F, Finger T, Restrepo D, Williams T. Disorganized olfactory bulb lamination in mice deficient for transcription factor AP-2epsilon. Mol Cell Neurosci. 2009;42:161-71 pubmed publisher
    ..We also show that Cre recombinase expression directed by the AP-2epsilon locus can specifically target floxed genes within the olfactory bulb, extending the utility of this AK allele. ..
  44. Adwanikar H, Karim F, Gereau R. Inflammation persistently enhances nocifensive behaviors mediated by spinal group I mGluRs through sustained ERK activation. Pain. 2004;111:125-35 pubmed
  45. Mansouri M, Kasugai Y, Fukazawa Y, Bertaso F, Raynaud F, Perroy J, et al. Distinct subsynaptic localization of type 1 metabotropic glutamate receptors at glutamatergic and GABAergic synapses in the rodent cerebellar cortex. Eur J Neurosci. 2015;41:157-67 pubmed publisher
    ..The identification of interactors that regulate the subsynaptic localization of the mGlu1 receptor at neurochemically distinct synapses may offer new insight into its trafficking and intracellular signalling. ..
  46. Karl T, Burne T, van den Buuse M, Chesworth R. Do transmembrane domain neuregulin 1 mutant mice exhibit a reliable sensorimotor gating deficit?. Behav Brain Res. 2011;223:336-41 pubmed publisher
    ..The research suggests that analysing one of the alleged hallmarks of animal models for schizophrenia must be done carefully: to obtain reliable PPI data it seems necessary to use more than one particular PPI protocol. ..
  47. Nakamura M, Sato K, Fukaya M, Araishi K, Aiba A, Kano M, et al. Signaling complex formation of phospholipase Cbeta4 with metabotropic glutamate receptor type 1alpha and 1,4,5-trisphosphate receptor at the perisynapse and endoplasmic reticulum in the mouse brain. Eur J Neurosci. 2004;20:2929-44 pubmed
    ..This close molecular relationship might provide PLCbeta4 with a high-fidelity effector function to mediate various neuronal responses under physiological and pathophysiological conditions. ..
  48. Lam Y, Sherman S. Activation of both Group I and Group II metabotropic glutamatergic receptors suppress retinogeniculate transmission. Neuroscience. 2013;242:78-84 pubmed publisher
    ..We also found high-frequency stimulation of the layer 6 corticothalamic input produced a similar suppression of retinogeniculate EPSCs, suggesting layer 6 projection to LGN as a plausible source of activating these presynaptic mGluRs. ..
  49. Ikeda M, Hirono M, Sugiyama T, Moriya T, Ikeda Sagara M, Eguchi N, et al. Phospholipase C-beta4 is essential for the progression of the normal sleep sequence and ultradian body temperature rhythms in mice. PLoS ONE. 2009;4:e7737 pubmed publisher
    ..These lines of evidence indicate that impaired LGNd relay, possibly mediated via group-1 mGluR, may underlie irregular sleep sequences and ultradian body temperature rhythms in PLC-beta4-/- mice. ..
  50. Levenes C, Daniel H, Jaillard D, Conquet F, Crepel F. Incomplete regression of multiple climbing fibre innervation of cerebellar Purkinje cells in mGLuR1 mutant mice. Neuroreport. 1997;8:571-4 pubmed thin cerebellar slices prepared from adult mutant mice deficient in metabotropic glutamate receptors of the mGluR1 subtype, only 15% of Purkinje cells remained multiply innervated by climbing fibres, but motor coordination was ..
  51. Cronin J, Watkins Chow D, Incao A, Hasskamp J, Schönewolf N, Aoude L, et al. SOX10 ablation arrests cell cycle, induces senescence, and suppresses melanomagenesis. Cancer Res. 2013;73:5709-18 pubmed publisher
    ..SOX10 expression for proliferation and SOX10 haploinsufficiency reduces melanoma initiation in the metabotropic glutamate receptor 1 (Grm1(Tg)) transgenic mouse model...
  52. Charette J, SAMUELS I, Yu M, Stone L, Hicks W, Shi L, et al. A Chemical Mutagenesis Screen Identifies Mouse Models with ERG Defects. Adv Exp Med Biol. 2016;854:177-83 pubmed publisher
    ..In this chapter, we report the identification of mouse models for Grm1, Grk1 and Lrit3. Each of these is characterized by a primary defect in the electroretinogram...
  53. Young S, Chuang S, Zhao W, Wong R, Bianchi R. Persistent receptor activity underlies group I mGluR-mediated cellular plasticity in CA3 neuron. J Neurosci. 2013;33:2526-40 pubmed publisher
    ..and the underlying excitatory cellular responses maintained following induction were reversibly blocked by mGluR1 antagonists [(S)-+-?-amino-4-carboxy-2-methylbenzeneacetic acid (LY 367385), 50, 100 ?m; CPCCOEt (hydroxyimino)..
  54. Feng W, Williams T. Cloning and characterization of the mouse AP-2 epsilon gene: a novel family member expressed in the developing olfactory bulb. Mol Cell Neurosci. 2003;24:460-75 pubmed
    ..A comparison of AP-2 gene family expression in the olfactory system suggests both distinct and overlapping functions for these transcription factors in forebrain development. ..
  55. Cartmell J, Schoepp D. Regulation of neurotransmitter release by metabotropic glutamate receptors. J Neurochem. 2000;75:889-907 pubmed
    ..This review addresses the neurochemical evidence for mGlu receptor-mediated regulation of neurotransmitters, such as excitatory and inhibitory amino acids, monoamines, and neuropeptides. ..
  56. Roh S, Hong Y, Jang D, Kim J, Kim S. Lipid rafts serve as signaling platforms for mGlu1 receptor-mediated calcium signaling in association with caveolin. Mol Brain. 2014;7:9 pubmed publisher
    ..Taken together, these results suggest that the binding of mGlu1? receptor to caveolin is crucial for its lipid rafts localization and mGlu1? receptor-mediated Ca2+ transients. ..
  57. Gugger O, Hartmann J, Birnbaumer L, Kapfhammer J. P/Q-type and T-type calcium channels, but not type 3 transient receptor potential cation channels, are involved in inhibition of dendritic growth after chronic metabotropic glutamate receptor type 1 and protein kinase C activation in cerebellar Purki. Eur J Neurosci. 2012;35:20-33 pubmed publisher
    ..channels (TRPC3s), P/Q-type Ca(2+) channels, and T-type Ca(2+) channels, might be involved in signaling after mGluR1 or PKC stimulation...
  58. Fontaine R, Olivier P, Massonneau V, Leroux P, Degos V, Lebon S, et al. Vulnerability of white matter towards antenatal hypoxia is linked to a species-dependent regulation of glutamate receptor subunits. Proc Natl Acad Sci U S A. 2008;105:16779-84 pubmed publisher
    ..subunits -1, 2, and -4; of the kainate-receptor subunit GluR7; and of the metabotropic receptor subunits mGluR1, -2, -3, -5, and -7. None of the glutamate-receptor subunits was down-regulated in the hypoxic rat pups...
  59. Frausto S, Ito K, Marszalec W, Swanson G. A novel form of low-frequency hippocampal mossy fiber plasticity induced by bimodal mGlu1 receptor signaling. J Neurosci. 2011;31:16897-906 pubmed publisher
    ..A slowly reversible state of enhanced synaptic efficacy could serve as a mechanism for altering the integrative properties of this synapse within a relatively broad temporal window. ..
  60. Tappe Theodor A, Fu Y, Kuner R, Neugebauer V. Homer1a signaling in the amygdala counteracts pain-related synaptic plasticity, mGluR1 function and pain behaviors. Mol Pain. 2011;7:38 pubmed publisher
    Group I metabotropic glutamate receptor (mGluR1/5) signaling is an important mechanism of pain-related plasticity in the amygdala that plays a key role in the emotional-affective dimension of pain...
  61. Yamasaki M, Miyazaki T, Azechi H, Abe M, Natsume R, Hagiwara T, et al. Glutamate receptor ?2 is essential for input pathway-dependent regulation of synaptic AMPAR contents in cerebellar Purkinje cells. J Neurosci. 2011;31:3362-74 pubmed publisher
    ..These results suggest that GluR?2 is involved in a common mechanism that restricts the number of synaptic AMPARs at PF synapses in PCs and molecular layer interneurons. ..
  62. Vincent A, Sportouch C, Covinhes A, Barrère C, Gallot L, Delgado Betancourt V, et al. Cardiac mGluR1 metabotropic receptors in cardioprotection. Cardiovasc Res. 2017;113:644-655 pubmed publisher
    In a previous study using a genome-wide microarray strategy, we identified metabotropic glutamate receptor 1 (mGluR1) as a putative cardioprotective candidate in ischaemic postconditioning (PostC)...
  63. Conquet F, Bashir Z, Davies C, Daniel H, Ferraguti F, Bordi F, et al. Motor deficit and impairment of synaptic plasticity in mice lacking mGluR1. Nature. 1994;372:237-43 pubmed
    b>Metabotropic glutamate receptor 1 (mGluR1) is a member of a large family of G-protein-coupled glutamate receptors, the physiological functions of which are largely unknown...
  64. Calo L, Bruno V, Spinsanti P, Molinari G, Korkhov V, Esposito Z, et al. Interactions between ephrin-B and metabotropic glutamate 1 receptors in brain tissue and cultured neurons. J Neurosci. 2005;25:2245-54 pubmed
    ..A functional interaction between ephrinB and mGlu1 receptors, which likely involves adaptor or scaffolding proteins, might have an important role in the regulation of developmental plasticity. ..
  65. Verpelli C, Dvoretskova E, Vicidomini C, Rossi F, Chiappalone M, Schoen M, et al. Importance of Shank3 protein in regulating metabotropic glutamate receptor 5 (mGluR5) expression and signaling at synapses. J Biol Chem. 2011;286:34839-50 pubmed publisher
  66. Tomioka N, Yasuda H, Miyamoto H, Hatayama M, Morimura N, Matsumoto Y, et al. Elfn1 recruits presynaptic mGluR7 in trans and its loss results in seizures. Nat Commun. 2014;5:4501 pubmed publisher
    ..These results reveal a novel mechanism for interneuron subtype-specific neural circuit establishment and define a common basis bridging neurological disorders. ..
  67. Pandya N, Klaassen R, van der Schors R, Slotman J, Houtsmuller A, Smit A, et al. Group 1 metabotropic glutamate receptors 1 and 5 form a protein complex in mouse hippocampus and cortex. Proteomics. 2016;16:2698-2705 pubmed publisher
    The group 1 metabotropic glutamate receptors 1 and 5 (mGluR1/5) have been implicated in mechanisms of synaptic plasticity and may serve as potential therapeutic targets in autism spectrum disorders...
  68. Sohn J, Yu W, Lee D, Shin H, Lee S, Ho W. Cyclic ADP ribose-dependent Ca2+ release by group I metabotropic glutamate receptors in acutely dissociated rat hippocampal neurons. PLoS ONE. 2011;6:e26625 pubmed publisher
    Group I metabotropic glutamate receptors (group I mGluRs; mGluR1 and mGluR5) exert diverse effects on neuronal and synaptic functions, many of which are regulated by intracellular Ca(2+)...
  69. Thomsen C, Klitgaard H, Sheardown M, Jackson H, Eskesen K, Jacobsen P, et al. (S)-4-carboxy-3-hydroxyphenylglycine, an antagonist of metabotropic glutamate receptor (mGluR) 1a and an agonist of mGluR2, protects against audiogenic seizures in DBA/2 mice. J Neurochem. 1994;62:2492-5 pubmed
    ..These data suggest that the anticonvulsant action of (S)-4C3HPG is mediated by combined antagonism of mGluR1a and agonism of mGluR2. These results suggest the importance of mGluR1a and/or mGluR2 in the control of epileptic activity. ..
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    Deleterious mutations in the glutamate receptor metabotropic 1 gene (GRM1) cause a recessive form of cerebellar ataxia, SCAR13. GRM1 and GRM5 code for the metabotropic glutamate type 1 (mGlu1) and type 5 (mGlu5) receptors, respectively...
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    ..alcohol-induced increases in the expression and function of the Group1 metabotropic glutamate receptor subtype 1 (mGluR1) within the extended amygdala are theorized to contribute to an individual's propensity to consume excessive ..
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    ..heteromers of taste receptor type 1, members 1 and 3 (T1R1+T1R3), and metabotropic glutamate receptors 1 and 4 (mGluR1 and mGluR4). Multiple lines of evidence support the involvement of T1R1+T1R3 in umami responses of mice...
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    ..coimmunoprecipitation, and colocalization experiments showed that group I metabotropic glutamate receptors (mGluR1/5) associate with PrP(C)...
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    ..Using linkage analysis, we mapped the crv4 locus to the proximal region of chromosome 10, at the location of the Grm1 gene. Genetic complementation crosses between crv4 and Grm1 KO mice confirmed that crv4 is a new allele of Grm1...
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    ..Recently, we detected metabotropic glutamate receptor-1 (gene: GRM1; protein: mGluR1) in breast cancer and found that it plays a role in the regulation of cell proliferation and tumor growth...
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    ..Collectively, these results show that DRG-derived glutamate is essential for the proper development, maintenance and sensory function of the piloneural mechanoreceptor. ..
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    ..The cloned receptors negatively couple to adenylyl cyclase and show sequence similarity to the metabotropic receptors for the excitatory neurotransmitter L-glutamate. ..
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    ..of PCs with impaired PF synaptogenesis, whereas mutation of the metabotropic glutamate receptor subtype 1 (mGluR1) gene causes multiple CF innervation with normal PF synaptogenesis...
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    In metabotropic glutamate receptor-subtype 1 (mGluR1)-null (mGluR1-/-) mice, cerebellar long-term depression (LTD) and several forms of memory are impaired...