Gene Symbol: Grip1
Description: glutamate receptor interacting protein 1
Alias: 4931400F03Rik, GRIP, glutamate receptor-interacting protein 1, eye blebs
Species: mouse
Products:     Grip1

Top Publications

  1. Osten P, Khatri L, Perez J, Kohr G, Giese G, Daly C, et al. Mutagenesis reveals a role for ABP/GRIP binding to GluR2 in synaptic surface accumulation of the AMPA receptor. Neuron. 2000;27:313-25 pubmed
    We studied the role of PDZ proteins GRIP, ABP, and PICK1 in GluR2 AMPA receptor trafficking. An epitope-tagged MycGluR2 subunit, when expressed in hippocampal cultured neurons, was specifically targeted to the synaptic surface...
  2. Setou M, Seog D, Tanaka Y, Kanai Y, Takei Y, Kawagishi M, et al. Glutamate-receptor-interacting protein GRIP1 directly steers kinesin to dendrites. Nature. 2002;417:83-7 pubmed
    ..that an AMPA (alpha-amino-3-hydroxy-5-methylisoxazole-4-propionate) receptor subunit--GluR2-interacting protein (GRIP1)--can directly interact and steer kinesin heavy chains to dendrites as a motor for AMPA receptors...
  3. Chen D, Ma H, Hong H, Koh S, Huang S, Schurter B, et al. Regulation of transcription by a protein methyltransferase. Science. 1999;284:2174-7 pubmed
    The p160 family of coactivators, SRC-1, GRIP1/TIF2, and p/CIP, mediate transcriptional activation by nuclear hormone receptors...
  4. Mao L, Takamiya K, Thomas G, Lin D, Huganir R. GRIP1 and 2 regulate activity-dependent AMPA receptor recycling via exocyst complex interactions. Proc Natl Acad Sci U S A. 2010;107:19038-43 pubmed publisher
    ..b>GRIP1 and GRIP2 are homologous multi-PDZ domain-containing proteins that bind to the C-termini of AMPA-R GluA2 and GluA3 ..
  5. Kino T, Chrousos G. Tumor necrosis factor alpha receptor- and Fas-associated FLASH inhibit transcriptional activity of the glucocorticoid receptor by binding to and interfering with its interaction with p160 type nuclear receptor coactivators. J Biol Chem. 2003;278:3023-9 pubmed
    ..we performed yeast two-hybrid screening using the NRB domain of the glucocorticoid receptor-interacting protein 1 (GRIP1) as bait...
  6. Hirbec H, Perestenko O, Nishimune A, Meyer G, Nakanishi S, Henley J, et al. The PDZ proteins PICK1, GRIP, and syntenin bind multiple glutamate receptor subtypes. Analysis of PDZ binding motifs. J Biol Chem. 2002;277:15221-4 pubmed
    ..we have identified a series of glutamate receptor subunits that interact differentially with the PDZ proteins GRIP, PICK1, and syntenin...
  7. Hoogenraad C, Milstein A, Ethell I, Henkemeyer M, Sheng M. GRIP1 controls dendrite morphogenesis by regulating EphB receptor trafficking. Nat Neurosci. 2005;8:906-15 pubmed
    The function of the multi-PDZ domain scaffold protein GRIP1 (glutamate receptor interacting protein 1) in neurons is unclear...
  8. Kiyozumi D, Sugimoto N, Sekiguchi K. Breakdown of the reciprocal stabilization of QBRICK/Frem1, Fras1, and Frem2 at the basement membrane provokes Fraser syndrome-like defects. Proc Natl Acad Sci U S A. 2006;103:11981-6 pubmed
    ..reduction in basement membrane deposition was also observed in another Fraser syndrome model mouse, in which GRIP1, a Fras1- and Frem2-interacting adaptor protein, is primarily affected...
  9. Yu G, Zerucha T, Ekker M, Rubenstein J. Evidence that GRIP, a PDZ-domain protein which is expressed in the embryonic forebrain, co-activates transcription with DLX homeodomain proteins. Brain Res Dev Brain Res. 2001;130:217-30 pubmed
    ..DIP2 appears to be an alternatively spliced form of GRIP1, a protein known to bind AMPA glutamate receptors via PDZ domains. Thus, we named it GRIP1b...

More Information


  1. Gupte R, Muse G, Chinenov Y, Adelman K, Rogatsky I. Glucocorticoid receptor represses proinflammatory genes at distinct steps of the transcription cycle. Proc Natl Acad Sci U S A. 2013;110:14616-21 pubmed publisher
    ..In conjunction with its corepressor GR-interacting protein-1 (GRIP1), GR tethers to the DNA-bound activator protein-1 and NF-?B and represses transcription of their target ..
  2. Han M, Mejias R, Chiu S, Rose R, Adamczyk A, Huganir R, et al. Mice lacking GRIP1/2 show increased social interactions and enhanced phosphorylation at GluA2-S880. Behav Brain Res. 2017;321:176-184 pubmed publisher
    Glutamate receptor interacting proteins 1 and 2 (GRIP1/2) play an important role in regulating synaptic trafficking of AMPA receptor 2/3 (GluA2/3) and synaptic strength...
  3. Chan C, Chen Y, Liu X, Tang X, Lee C, Mei L, et al. PIKE-mediated PI3-kinase activity is required for AMPA receptor surface expression. EMBO J. 2011;30:4274-86 pubmed publisher
    ..we show that PIKE (phosphoinositide 3-kinase enhancer) GTPases regulate neuronal AMPAR activity by promoting GluA2/GRIP1 association...
  4. Brown K, Hetzel S, Harne L. Craniofacial consequences of connective tissue disorders in mice. Birth Defects Orig Artic Ser. 1984;20:113-36 pubmed
  5. Osburn D, Shao G, Seidel H, Schulman I. Ligand-dependent degradation of retinoid X receptors does not require transcriptional activity or coactivator interactions. Mol Cell Biol. 2001;21:4909-18 pubmed
    ..Taken together, the data suggest a model for targeted destruction of transcription factors based on structural or conformational signals as opposed to functional coupling with gene transcription. ..
  6. Chinenov Y, Gupte R, Dobrovolna J, Flammer J, Liu B, Michelassi F, et al. Role of transcriptional coregulator GRIP1 in the anti-inflammatory actions of glucocorticoids. Proc Natl Acad Sci U S A. 2012;109:11776-81 pubmed publisher
    ..We created a mouse strain enabling a conditional hematopoietic cell-restricted deletion of GRIP1 in adult animals...
  7. Thomas G, Hayashi T, Chiu S, Chen C, Huganir R. Palmitoylation by DHHC5/8 targets GRIP1 to dendritic endosomes to regulate AMPA-R trafficking. Neuron. 2012;73:482-96 pubmed publisher
  8. Yamazaki M, Fukaya M, Abe M, Ikeno K, Kakizaki T, Watanabe M, et al. Differential palmitoylation of two mouse glutamate receptor interacting protein 1 forms with different N-terminal sequences. Neurosci Lett. 2001;304:81-4 pubmed
    ..To clarify the physiological functions of GRIP, we cloned mouse GRIP1, and found that there are three sites for alternative splicing and two putative translational start codons by ..
  9. Brückner K, Pablo Labrador J, Scheiffele P, Herb A, Seeburg P, Klein R. EphrinB ligands recruit GRIP family PDZ adaptor proteins into raft membrane microdomains. Neuron. 1999;22:511-24 pubmed
    ..Glutamate receptor-interacting protein (GRIP) and a highly related protein, which we have termed GRIP2, are recruited into these rafts through association with ..
  10. Barry J, Leong G, Church W, Issa L, Eisman J, Gardiner E. Interactions of SKIP/NCoA-62, TFIIB, and retinoid X receptor with vitamin D receptor helix H10 residues. J Biol Chem. 2003;278:8224-8 pubmed
    ..The p160 coactivator GRIP1 and the distinct coregulator Ski-interacting protein (SKIP)/NCoA-62 synergistically enhance ligand-dependent VDR ..
  11. Miao J, Fang S, Bae Y, Kemper J. Functional inhibitory cross-talk between constitutive androstane receptor and hepatic nuclear factor-4 in hepatic lipid/glucose metabolism is mediated by competition for binding to the DR1 motif and to the common coactivators, GRIP-1 and PGC-1alpha. J Biol Chem. 2006;281:14537-46 pubmed
    ..Furthermore, inhibition by CAR was reversed by expression of increasing amounts of GRIP-1 or PGC-1alpha, indicating that CAR competes with HNF-4 for these coactivators...
  12. Takamiya K, Mao L, Huganir R, Linden D. The glutamate receptor-interacting protein family of GluR2-binding proteins is required for long-term synaptic depression expression in cerebellar Purkinje cells. J Neurosci. 2008;28:5752-5 pubmed publisher
    Glutamate receptor-interacting protein 1 (GRIP1) and GRIP2 are closely related proteins that bind GluR2-containing AMPA receptors and couple them to structural and signaling complexes in neurons...
  13. Tan H, Queenan B, Huganir R. GRIP1 is required for homeostatic regulation of AMPAR trafficking. Proc Natl Acad Sci U S A. 2015;112:10026-31 pubmed publisher
    ..Here, we show that the expression of GRIP1, a multi-PDZ (postsynaptic density 95/discs large/zona occludens) domain AMPAR-binding protein, is bidirectionally ..
  14. Chatterjee N, Stegmuller J, Schätzle P, Karram K, Koroll M, Werner H, et al. Interaction of syntenin-1 and the NG2 proteoglycan in migratory oligodendrocyte precursor cells. J Biol Chem. 2008;283:8310-7 pubmed publisher
    ..Thus syntenin plays a role in the migration of oligodendroglial precursors, and we suggest that NG2-syntenin-1 interactions contribute to this. ..
  15. Stegmuller J, Werner H, Nave K, Trotter J. The proteoglycan NG2 is complexed with alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptors by the PDZ glutamate receptor interaction protein (GRIP) in glial progenitor cells. Implications for glial-neuronal signaling. J Biol Chem. 2003;278:3590-8 pubmed
    ..region of NG2 as bait in a yeast two-hybrid screen, we identified the glutamate receptor interaction protein GRIP1, a multi-PDZ domain protein, as an interacting partner...
  16. Zhang J, Wang Y, Chi Z, Keuss M, Pai Y, Kang H, et al. The AAA+ ATPase Thorase regulates AMPA receptor-dependent synaptic plasticity and behavior. Cell. 2011;145:284-99 pubmed publisher
    ..In an ATPase-dependent manner Thorase mediates the internalization of AMPAR by disassembling the AMPAR-GRIP1 complex...
  17. Kim P, Aizawa H, Kim P, Huang A, Wickramasinghe S, Kashani A, et al. Serine racemase: activation by glutamate neurotransmission via glutamate receptor interacting protein and mediation of neuronal migration. Proc Natl Acad Sci U S A. 2005;102:2105-10 pubmed
    ..alpha-amino-3-hydroxy-5-methylisoxazole-4-propionic acid receptors via glutamate receptor interacting protein (GRIP) and the physiologic regulation of cerebellar granule cell migration by SR...
  18. Zürner M, Schoch S. The mouse and human Liprin-alpha family of scaffolding proteins: genomic organization, expression profiling and regulation by alternative splicing. Genomics. 2009;93:243-53 pubmed publisher
    ..Interestingly, regulation via alternative splicing is not conserved between isoforms and across species and represents a post-transcriptional mechanism to independently diversify the properties of the individual isoforms. ..
  19. Jonason A, Baker S, Sweasy J. Interaction of DNA polymerase beta with GRIP1 during meiosis. Chromosoma. 2001;110:402-10 pubmed
    ..Here we show that a multiple PDZ domain-containing protein, the glutamate receptor interacting protein 1 (GRIP1), interacts specifically with pol beta...
  20. Briand L, Kimmey B, Ortinski P, Huganir R, Pierce R. Disruption of glutamate receptor-interacting protein in nucleus accumbens enhances vulnerability to cocaine relapse. Neuropsychopharmacology. 2014;39:759-69 pubmed publisher
    ..Glutamate receptor-interacting protein (GRIP) is a neuronal scaffolding protein that stabilizes GluA2 AMPARs at synapses but its role in cocaine addiction has ..
  21. Kiyozumi D, Sugimoto N, Nakano I, Sekiguchi K. Frem3, a member of the 12 CSPG repeats-containing extracellular matrix protein family, is a basement membrane protein with tissue distribution patterns distinct from those of Fras1, Frem2, and QBRICK/Frem1. Matrix Biol. 2007;26:456-62 pubmed
    ..These results indicate that Frem3 is a basement membrane protein that is distinct from other 12-CSPG proteins in its tissue distribution and competence to assemble into the basement membrane. ..
  22. Modjeski K, Ture S, Field D, Cameron S, Morrell C. Glutamate Receptor Interacting Protein 1 Mediates Platelet Adhesion and Thrombus Formation. PLoS ONE. 2016;11:e0160638 pubmed publisher
    ..b>Glutamate receptor interacting protein 1 (GRIP1) is a large scaffolding protein that localizes and organizes interacting proteins in other ..
  23. Torres R, Firestein B, Dong H, Staudinger J, Olson E, Huganir R, et al. PDZ proteins bind, cluster, and synaptically colocalize with Eph receptors and their ephrin ligands. Neuron. 1998;21:1453-63 pubmed
    ..Thus, PDZ proteins may play critical roles in localizing vertebrate receptor tyrosine kinases and/or their ligands and may be particularly important for Eph function in guidance or patterning or at the synapse. ..
  24. Schwartz I, Keh A, Hsu G. Morphology, GluR1 and GRIP-C localization differ in octopus cells of C57BL6 and B6Cast mice. Hear Res. 2002;171:1-12 pubmed
    ..8-week-old B6 and B6Cast mice, and the immunolocalization of antibodies to GluR1 (glutamate receptor subunit 1) and GRIP-C (glutamate receptor interacting protein-C terminus)...
  25. Kaplan O, Doroquez D, Cevik S, Bowie R, Clarke L, Sanders A, et al. Endocytosis genes facilitate protein and membrane transport in C. elegans sensory cilia. Curr Biol. 2012;22:451-60 pubmed publisher
  26. Cho I, Kim S. A novel mitogen-activated protein kinase phosphatase-1 and glucocorticoid receptor (GR) interacting protein-1-dependent combinatorial mechanism of gene transrepression by GR. Mol Endocrinol. 2009;23:86-99 pubmed publisher
    ..and transfection assays revealed that a p65 DNA complex involving GR-bound GR-interacting protein 1 (GRIP1) also contributed to COX-2 repression...
  27. Gupta P, Park S, Farooqui M, Wei L. Orphan nuclear receptor TR2, a mediator of preadipocyte proliferation, is differentially regulated by RA through exchange of coactivator PCAF with corepressor RIP140 on a platform molecule GRIP1. Nucleic Acids Res. 2007;35:2269-82 pubmed
    ..differential RA-dependent coregulator recruitment to the receptor/Glucocorticoid Receptor-Interacting Protein 1 (GRIP1) complex that binds IR0 on the TR2 promoter...
  28. Zhou Y, Foster F, Qu D, Zhang M, Harasiewicz K, Adamson S. Applications for multifrequency ultrasound biomicroscopy in mice from implantation to adulthood. Physiol Genomics. 2002;10:113-26 pubmed
    ..The coefficient of variation of carotid and aortic diameter measurements was 1-3%. In addition, blisters in GRIP1 -/- embryos and aortic valvular stenosis in two adults were readily visualized...
  29. Hong H, Kohli K, Trivedi A, Johnson D, Stallcup M. GRIP1, a novel mouse protein that serves as a transcriptional coactivator in yeast for the hormone binding domains of steroid receptors. Proc Natl Acad Sci U S A. 1996;93:4948-52 pubmed
    ..cDNA library that codes for a novel 812-aa long protein fragment, glucocorticoid receptor-interacting protein 1 (GRIP1), that can interact with the hormone binding domain (HBD) of the glucocorticoid receptor...
  30. Heisler F, Lee H, Gromova K, Pechmann Y, Schurek B, Ruschkies L, et al. GRIP1 interlinks N-cadherin and AMPA receptors at vesicles to promote combined cargo transport into dendrites. Proc Natl Acad Sci U S A. 2014;111:5030-5 pubmed publisher
    ..We report that N-cadherin binds to PSD-95/SAP90/DLG/ZO-1 (PDZ) domain 2 of the glutamate receptor interacting protein 1 (GRIP1) through its intracellular C terminus...
  31. Takamiya K, Kostourou V, Adams S, Jadeja S, Chalepakis G, Scambler P, et al. A direct functional link between the multi-PDZ domain protein GRIP1 and the Fraser syndrome protein Fras1. Nat Genet. 2004;36:172-7 pubmed
    ..Here we describe how the loss of a cytoplasmic multi-PDZ scaffolding protein, glutamate receptor interacting protein 1 (GRIP1), leads to the formation of subepidermal hemorrhagic blisters, renal agenesis, syndactyly ..
  32. Huang S, Huang C, Wang W, Kang J, Hsu W. The enhancement of nuclear receptor transcriptional activation by a mouse actin-binding protein, alpha actinin 2. J Mol Endocrinol. 2004;32:481-96 pubmed
    The p160 coactivators, steroid receptor coactivator 1, glucocorticoid receptor interacting protein 1 (GRIP1) and the activator of thyroid and retinoic acid receptor, have two activation domains, AD1 and AD2, which transmit the activation ..
  33. Irino Y, Ichinohe M, Nakamura Y, Nakahara M, Fukami K. Phospholipase Cdelta4 associates with glutamate receptor interacting protein 1 in testis. J Biochem. 2005;138:451-6 pubmed
    ..we focused on the function of the C2 domain of PLCdelta4 and report that glutamate receptor-interacting protein1 (GRIP1) was identified as a binding protein of the PLCdelta4-C2 domain on yeast two-hybrid screening...
  34. Lv K, Chen L, Li Y, Li Z, Zheng P, Liu Y, et al. Trip6 promotes dendritic morphogenesis through dephosphorylated GRIP1-dependent myosin VI and F-actin organization. J Neurosci. 2015;35:2559-71 pubmed publisher
    ..Through interaction with the glutamate receptor-interacting protein 1 (GRIP1) and myosin VI, Trip6 is crucial for the total dendritic length and the number of primary dendrites in cultured ..
  35. Bladt F, Tafuri A, Gelkop S, Langille L, Pawson T. Epidermolysis bullosa and embryonic lethality in mice lacking the multi-PDZ domain protein GRIP1. Proc Natl Acad Sci U S A. 2002;99:6816-21 pubmed
    Glutamate receptor-interacting protein 1 (GRIP1) is an adaptor protein composed of seven PDZ (postsynaptic density-95/Discs large/zona occludens-1) domains, capable of mediating diverse protein-protein interactions...
  36. Poore C, Sundaram J, Pareek T, Fu A, Amin N, Mohamed N, et al. Cdk5-mediated phosphorylation of delta-catenin regulates its localization and GluR2-mediated synaptic activity. J Neurosci. 2010;30:8457-67 pubmed publisher
    ..This study reveals how Cdk5 phosphorylation of the synaptic mediator protein delta-catenin can alter its localization at the synapse to impact neuronal synaptic activity. ..
  37. Seog D. Glutamate receptor-interacting protein 1 protein binds to the microtubule-associated protein. Biosci Biotechnol Biochem. 2004;68:1808-10 pubmed
    ..propionate (AMPA) receptor subunit glutamate receptor-interacting protein 1 (GRIP1), GRIP1 interactions with microtubule-associated protein (MAP)-1B light chain (LC) were investigated...
  38. Lai C, Xie C, McCormack S, Chiang H, Michalak M, Lin X, et al. Amyotrophic lateral sclerosis 2-deficiency leads to neuronal degeneration in amyotrophic lateral sclerosis through altered AMPA receptor trafficking. J Neurosci. 2006;26:11798-806 pubmed
    ..Here, we report that alsin interacted with glutamate receptor interacting protein 1 (GRIP1) both in vitro and in vivo, and colocalized with GRIP1 in neurons...
  39. Lee Y, Stallcup M. Interplay of Fli-I and FLAP1 for regulation of beta-catenin dependent transcription. Nucleic Acids Res. 2006;34:5052-9 pubmed
    ..endogenous FLAP1 levels compromised transcriptional activation by LEF1/TCF, beta-catenin and the p160 coactivator GRIP1. FLAP1 interacted directly with beta-catenin, GRIP1 and p300 and enhanced their activity...
  40. Geiger J, Lipka J, Segura I, Hoyer S, Schlager M, Wulf P, et al. The GRIP1/14-3-3 pathway coordinates cargo trafficking and dendrite development. Dev Cell. 2014;28:381-93 pubmed publisher
    ..Here, we show by genetic deletion in mice that the multi-PDZ domain scaffolding protein glutamate receptor interacting protein 1 (GRIP1) is required for dendrite development...
  41. Uemura T, Mori H, Mishina M. Direct interaction of GluRdelta2 with Shank scaffold proteins in cerebellar Purkinje cells. Mol Cell Neurosci. 2004;26:330-41 pubmed
    ..Furthermore, Shank2 interacted with GRIP1 in the cerebellum...
  42. Xia J, Kemper B. Structural determinants of constitutive androstane receptor required for its glucocorticoid receptor interacting protein-1-mediated nuclear accumulation. J Biol Chem. 2005;280:7285-93 pubmed
    ..We have shown that exogenous expression of the p160 coactivator glucocorticoid receptor interacting protein-1 (GRIP1) in hepatocytes in vivo can mediate PB-independent nuclear accumulation of murine CAR (mCAR)...
  43. Swiergiel J, Funderburgh J, Justice M, Conrad G. Developmental eye and neural tube defects in the eye blebs mouse. Dev Dyn. 2000;219:21-7 pubmed
    In the mouse, eye blebs (eb) is a spontaneous mutation that presents a useful model for the study of abnormal eye development...
  44. Karataeva A, Klaassen R, Ströder J, Ruiperez Alonso M, Hjorth J, Van Nierop P, et al. C-terminal interactors of the AMPA receptor auxiliary subunit Shisa9. PLoS ONE. 2014;9:e87360 pubmed publisher
    ..Taken together, our data identifies novel interaction partners of Shisa9, and shows that the C-terminal interactions of Shisa9 through its PDZ domain interaction motif are important for AMPA receptor synaptic and network functions. ..
  45. Mejias R, Adamczyk A, Anggono V, Niranjan T, Thomas G, Sharma K, et al. Gain-of-function glutamate receptor interacting protein 1 variants alter GluA2 recycling and surface distribution in patients with autism. Proc Natl Acad Sci U S A. 2011;108:4920-5 pubmed publisher
    b>Glutamate receptor interacting protein 1 (GRIP1) is a neuronal scaffolding protein that interacts directly with the C termini of glutamate receptors 2/3 (GluA2/3) via its PDZ domains 4 to 6 (PDZ4-6). We found an association (P<0...
  46. Yang H, Takagi H, Konishi Y, Ageta H, Ikegami K, Yao I, et al. Transmembrane and ubiquitin-like domain-containing protein 1 (Tmub1/HOPS) facilitates surface expression of GluR2-containing AMPA receptors. PLoS ONE. 2008;3:e2809 pubmed publisher
    ..Eventually, we found that GluR2 and glutamate receptor interacting protein (GRIP) were coimmunoprecipitated by the anti-Tmub1/HOPS antibody from the mouse brain...
  47. Liu K, Lei R, Li Q, Wang X, Wu Q, An P, et al. Transferrin Receptor Controls AMPA Receptor Trafficking Efficiency and Synaptic Plasticity. Sci Rep. 2016;6:21019 pubmed publisher
    ..Thus, our study reveals that TFR functions as a novel regulator to control AMPA trafficking efficiency and synaptic plasticity. ..
  48. Nakata A, Ito T, Nagata M, Hori S, Sekimizu K. GRIP1tau, a novel PDZ domain-containing transcriptional activator, cooperates with the testis-specific transcription elongation factor SII-T1. Genes Cells. 2004;9:1125-35 pubmed
    ..GRIP1tau is a novel isoform of glutamate receptor-interacting protein 1 (GRIP1) that associates with the cytoplasmic domain of the alpha-amino-3-hydroxy-5-methyl-4-isoaxazolepropionate (AMPA)-..
  49. Hoang T, Fenne I, Cook C, Børud B, Bakke M, Lien E, et al. cAMP-dependent protein kinase regulates ubiquitin-proteasome-mediated degradation and subcellular localization of the nuclear receptor coactivator GRIP1. J Biol Chem. 2004;279:49120-30 pubmed
    Nuclear receptors and their coactivators are key regulators of numerous physiological functions. GRIP1 (glucocorticoid receptor-interacting protein) is a member of the steroid receptor coactivator family...