Gene Symbol: Grin2b
Description: glutamate receptor, ionotropic, NMDA2B (epsilon 2)
Alias: AW490526, GluN2B, NR2B, Nmdar2b, glutamate receptor ionotropic, NMDA 2B, GluRepsilon2, N-methyl D-aspartate receptor 2B, N-methyl D-aspartate receptor subtype 2B, glutamate [NMDA] receptor subunit epsilon-2
Species: mouse
Products:     Grin2b

Top Publications

  1. Yin X, Takei Y, Kido M, Hirokawa N. Molecular motor KIF17 is fundamental for memory and learning via differential support of synaptic NR2A/2B levels. Neuron. 2011;70:310-25 pubmed publisher
    ..superfamily motor protein 17 (KIF17) is a candidate transporter of N-methyl-D-aspartate (NMDA) receptor subunit 2B (NR2B)...
  2. Hawasli A, Benavides D, Nguyen C, Kansy J, Hayashi K, Chambon P, et al. Cyclin-dependent kinase 5 governs learning and synaptic plasticity via control of NMDAR degradation. Nat Neurosci. 2007;10:880-886 pubmed publisher
    ..Enhanced synaptic plasticity in Cdk5 knockout mice was attributed to reduced NR2B degradation, which caused elevations in total, surface and synaptic NR2B subunit levels and current through NR2B-..
  3. Akashi K, Kakizaki T, Kamiya H, Fukaya M, Yamasaki M, Abe M, et al. NMDA receptor GluN2B (GluR epsilon 2/NR2B) subunit is crucial for channel function, postsynaptic macromolecular organization, and actin cytoskeleton at hippocampal CA3 synapses. J Neurosci. 2009;29:10869-82 pubmed publisher
    GluN2B (GluRepsilon2/NR2B) subunit is involved in synapse development, synaptic plasticity, and cognitive function...
  4. Krapivinsky G, Krapivinsky L, Manasian Y, Ivanov A, Tyzio R, Pellegrino C, et al. The NMDA receptor is coupled to the ERK pathway by a direct interaction between NR2B and RasGRF1. Neuron. 2003;40:775-84 pubmed
    ..Here we show that NR2B, but not NR2A or NR1 subunits of the NMDAR, interacts in vivo and in vitro with RasGRF1, a Ca(2+)/calmodulin-..
  5. Cao X, Cui Z, Feng R, Tang Y, Qin Z, Mei B, et al. Maintenance of superior learning and memory function in NR2B transgenic mice during ageing. Eur J Neurosci. 2007;25:1815-22 pubmed
    ..Here, we test the hypothesis that up-regulation of NR2B expression is beneficial for learning and memory in the aged animals...
  6. Watanabe M, Mishina M, Inoue Y. Differential distributions of the NMDA receptor channel subunit mRNAs in the mouse retina. Brain Res. 1994;634:328-32 pubmed
    ..These findings suggest that molecular organization of the NMDA receptor channel may alter during the retinal development. ..
  7. Cui Y, Jin J, Zhang X, Xu H, Yang L, Du D, et al. Forebrain NR2B overexpression facilitating the prefrontal cortex long-term potentiation and enhancing working memory function in mice. PLoS ONE. 2011;6:e20312 pubmed publisher
    ..However, there is little information regarding the roles of NMDA receptor NR2B subunit in prefrontal cortical synaptic plasticity and prefrontal cortex-related working memory...
  8. Snyder E, Nong Y, Almeida C, Paul S, Moran T, Choi E, et al. Regulation of NMDA receptor trafficking by amyloid-beta. Nat Neurosci. 2005;8:1051-8 pubmed
    ..Dephosphorylation of the NMDA receptor subunit NR2B at Tyr1472 correlated with receptor endocytosis...
  9. Jacobs S, Tsien J. genetic overexpression of NR2B subunit enhances social recognition memory for different strains and species. PLoS ONE. 2012;7:e36387 pubmed publisher
    ..role of the NMDA receptor in social recognition memory, specifically the consequences of altering the ratio of the NR2B:NR2A subunits in the forebrain regions in social behavior...

More Information


  1. Ryan T, Emes R, Grant S, Komiyama N. Evolution of NMDA receptor cytoplasmic interaction domains: implications for organisation of synaptic signalling complexes. BMC Neurosci. 2008;9:6 pubmed publisher
    ..The evolution of the NR2 C-terminus and its associated signalling complex may contribute to species differences in behaviour and in particular cognitive function. ..
  2. Brigman J, Wright T, Talani G, Prasad Mulcare S, Jinde S, Seabold G, et al. Loss of GluN2B-containing NMDA receptors in CA1 hippocampus and cortex impairs long-term depression, reduces dendritic spine density, and disrupts learning. J Neurosci. 2010;30:4590-600 pubmed publisher
    ..Here, we generated mice lacking GluN2B in pyramidal neurons of cortex and CA1 subregion of hippocampus...
  3. Berberich S, Jensen V, Hvalby Ø, Seeburg P, Köhr G. The role of NMDAR subtypes and charge transfer during hippocampal LTP induction. Neuropharmacology. 2007;52:77-86 pubmed
    ..frequency afferent stimulation (HFS), we found that genetic impairment of NR2A or pharmacological block of NR2A- or NR2B-type NMDARs can reduce field LTP...
  4. Liao G, Wagner D, Hsu M, Leonard J. Evidence for direct protein kinase-C mediated modulation of N-methyl-D-aspartate receptor current. Mol Pharmacol. 2001;59:960-4 pubmed
    ..Experiments using chimeras initially indicated that the cytoplasmic C-terminal tails of NR2B (responsive to PKC) and NR2C (unresponsive to PKC) subunits contain the amino acid residues responsible for the ..
  5. Fukaya M, Kato A, Lovett C, Tonegawa S, Watanabe M. Retention of NMDA receptor NR2 subunits in the lumen of endoplasmic reticulum in targeted NR1 knockout mice. Proc Natl Acad Sci U S A. 2003;100:4855-60 pubmed
    ..The NR1 gene deletion had no apparent effect on the levels of NR2A or NR2B mRNA but led to severe reductions of NR2A and NR2B protein in dendrites of CA1 pyramidal cells...
  6. Fontán Lozano A, Sáez Cassanelli J, Inda M, de los Santos Arteaga M, Sierra Domínguez S, Lopez Lluch G, et al. Caloric restriction increases learning consolidation and facilitates synaptic plasticity through mechanisms dependent on NR2B subunits of the NMDA receptor. J Neurosci. 2007;27:10185-95 pubmed
    ..In addition, we found an increase in the expression of the NMDA receptor subunit NR2B in some brain areas of L-IFD mice...
  7. Zhao M, Toyoda H, Lee Y, Wu L, Ko S, Zhang X, et al. Roles of NMDA NR2B subtype receptor in prefrontal long-term potentiation and contextual fear memory. Neuron. 2005;47:859-72 pubmed
    ..In particular, it has been suggested that NR2A-containing NMDA receptors are involved in LTP induction, whereas NR2B-containing receptors are involved in LTD induction in the hippocampus...
  8. Kutsuwada T, Kashiwabuchi N, Mori H, Sakimura K, Kushiya E, Araki K, et al. Molecular diversity of the NMDA receptor channel. Nature. 1992;358:36-41 pubmed
    ..These findings suggest that the molecular diversity of the epsilon subunit family underlies the functional heterogeneity of the NMDA receptor channel. ..
  9. Nakazawa T, Komai S, Tezuka T, Hisatsune C, Umemori H, Semba K, et al. Characterization of Fyn-mediated tyrosine phosphorylation sites on GluR epsilon 2 (NR2B) subunit of the N-methyl-D-aspartate receptor. J Biol Chem. 2001;276:693-9 pubmed
    ..of NMDA receptor tyrosine phosphorylation, we identified Fyn-mediated phosphorylation sites on the GluR epsilon 2 (NR2B) subunit of NMDA receptors...
  10. von Engelhardt J, Doganci B, Jensen V, Hvalby Ø, Göngrich C, Taylor A, et al. Contribution of hippocampal and extra-hippocampal NR2B-containing NMDA receptors to performance on spatial learning tasks. Neuron. 2008;60:846-60 pubmed publisher
    Controversy revolves around the differential contribution of NR2A- and NR2B-containing NMDA receptors, which coexist in principal forebrain neurons, to synaptic plasticity and learning in the adult brain...
  11. Faust T, Chang E, Kowal C, Berlin R, Gazaryan I, Bertini E, et al. Neurotoxic lupus autoantibodies alter brain function through two distinct mechanisms. Proc Natl Acad Sci U S A. 2010;107:18569-74 pubmed publisher
    ..We have studied lupus AAbs that bind dsDNA and cross-react with the NR2A and NR2B subunits of the NMDA receptor (NMDAR)...
  12. Bjarnadottir M, Misner D, Haverfield Gross S, Bruun S, Helgason V, Stefansson H, et al. Neuregulin1 (NRG1) signaling through Fyn modulates NMDA receptor phosphorylation: differential synaptic function in NRG1+/- knock-outs compared with wild-type mice. J Neurosci. 2007;27:4519-29 pubmed
    ..we show that NRG1 signaling, through activation of Fyn and Pyk2 kinases, stimulates phosphorylation of Y1472 on the NR2B subunit of the NMDA receptor (NMDAR), a key regulatory site that modulates channel properties...
  13. Zhang X, Wu L, Gong B, Ren M, Li B, Zhuo M. Induction- and conditioning-protocol dependent involvement of NR2B-containing NMDA receptors in synaptic potentiation and contextual fear memory in the hippocampal CA1 region of rats. Mol Brain. 2008;1:9 pubmed publisher
    ..Studies using genetic and pharmacological approaches have reported inconsistent results of the requirement of NR2B-containing NMDARs in LTP in the CA1 region...
  14. Köhr G, Jensen V, Koester H, Mihaljevic A, Utvik J, Kvello A, et al. Intracellular domains of NMDA receptor subtypes are determinants for long-term potentiation induction. J Neurosci. 2003;23:10791-9 pubmed
    ..synapses of adult mice, different NMDAR subtypes with distinct functionality assemble from NR1 with NR2A and/or NR2B subunits. Here we investigated the role of these NMDA receptor subtypes in long-term potentiation (LTP) induction...
  15. Takehara K, Kawahara S, Munemoto Y, Kuriyama H, Mori H, Mishina M, et al. The N-methyl-D-aspartate (NMDA)-type glutamate receptor GluRepsilon2 is important for delay and trace eyeblink conditioning in mice. Neurosci Lett. 2004;364:43-7 pubmed
    ..In order to specify the distinct participation of each of these subunits, we focused on the GluRepsilon2 subunits, which are expressed mainly in the forebrain...
  16. Tu W, Xu X, Peng L, Zhong X, Zhang W, Soundarapandian M, et al. DAPK1 interaction with NMDA receptor NR2B subunits mediates brain damage in stroke. Cell. 2010;140:222-34 pubmed publisher
    ..Here, we report that cerebral ischemia recruits death-associated protein kinase 1 (DAPK1) into the NMDA receptor NR2B protein complex in the cortex of adult mice...
  17. Wu L, Toyoda H, Zhao M, Lee Y, Tang J, Ko S, et al. Upregulation of forebrain NMDA NR2B receptors contributes to behavioral sensitization after inflammation. J Neurosci. 2005;25:11107-16 pubmed
    Transgenic overexpression of NMDA NR2B receptors in forebrain regions increased behavioral responses to persistent inflammatory pain...
  18. Watanabe M, Inoue Y, Sakimura K, Mishina M. Developmental changes in distribution of NMDA receptor channel subunit mRNAs. Neuroreport. 1992;3:1138-40 pubmed
    ..In contrast, the zeta 1 subunit mRNA distributes ubiquitously in the brain throughout development. These findings suggest that changes in the subunit composition of the NMDA receptor channel take place during brain development. ..
  19. Watanabe M, Mishina M, Inoue Y. Distinct spatiotemporal expressions of five NMDA receptor channel subunit mRNAs in the cerebellum. J Comp Neurol. 1994;343:513-9 pubmed
    ..These findings suggest that anatomical organization of the epsilon subunits is heterogeneous in the cerebellum both spatially and temporally, which would give rise to functional diversity of the NMDA receptor channel. ..
  20. Tang Y, Shimizu E, Dube G, Rampon C, Kerchner G, Zhuo M, et al. Genetic enhancement of learning and memory in mice. Nature. 1999;401:63-9 pubmed
    ..Here we show that overexpression of NMDA receptor 2B (NR2B) in the forebrains of transgenic mice leads to enhanced activation of NMDA receptors, facilitating synaptic ..
  21. Ryan T, Kopanitsa M, Indersmitten T, Nithianantharajah J, Afinowi N, Pettit C, et al. Evolution of GluN2A/B cytoplasmic domains diversified vertebrate synaptic plasticity and behavior. Nat Neurosci. 2013;16:25-32 pubmed publisher
    ..functions, we exchanged the exons encoding the GluN2A (also known as Grin2a) and GluN2B (also known as Grin2b) CTDs in two knock-in mice and analyzed the mice's biochemistry, synaptic physiology, and multiple learned and ..
  22. Berberich S, Punnakkal P, Jensen V, Pawlak V, Seeburg P, Hvalby Ø, et al. Lack of NMDA receptor subtype selectivity for hippocampal long-term potentiation. J Neurosci. 2005;25:6907-10 pubmed
    NMDA receptor (NMDAR) 2A (NR2A)- and NR2B-type NMDARs coexist in synapses of CA1 pyramidal cells...
  23. Wang X, MCCOY P, Rodriguiz R, Pan Y, Je H, Roberts A, et al. Synaptic dysfunction and abnormal behaviors in mice lacking major isoforms of Shank3. Hum Mol Genet. 2011;20:3093-108 pubmed publisher
    ..We conclude that loss of major Shank3 species produces biochemical, cellular and morphological changes, leading to behavioral abnormalities in mice that bear similarities to human ASD patients with SHANK3 mutations. ..
  24. Matsumura S, Kunori S, Mabuchi T, Katano T, Nakazawa T, Abe T, et al. Impairment of CaMKII activation and attenuation of neuropathic pain in mice lacking NR2B phosphorylated at Tyr1472. Eur J Neurosci. 2010;32:798-810 pubmed publisher
    ..We previously demonstrated that Fyn kinase-mediated phosphorylation of NR2B subunits of NMDA receptors at Tyr1472 in the dorsal horn was involved in a neuropathic pain state even 1 week after ..
  25. Wills T, Klug J, Silberman Y, Baucum A, Weitlauf C, Colbran R, et al. GluN2B subunit deletion reveals key role in acute and chronic ethanol sensitivity of glutamate synapses in bed nucleus of the stria terminalis. Proc Natl Acad Sci U S A. 2012;109:E278-87 pubmed publisher
    ..Thus, we use a conditional GluN2B KO mouse line to assess both basal and ethanol-dependent function of this subunit at glutamate synapses in the ..
  26. Abe T, Matsumura S, Katano T, Mabuchi T, Takagi K, Xu L, et al. Fyn kinase-mediated phosphorylation of NMDA receptor NR2B subunit at Tyr1472 is essential for maintenance of neuropathic pain. Eur J Neurosci. 2005;22:1445-54 pubmed
    ..Wild-type, NR2A-deficient, and NR2D-deficient mice developed neuropathic pain; in addition, phosphorylation of NR2B subunits of NMDA receptors at Tyr1472 was observed in the superficial dorsal horn of the spinal cord 1 week after ..
  27. Nakazawa T, Komai S, Watabe A, Kiyama Y, Fukaya M, Arima Yoshida F, et al. NR2B tyrosine phosphorylation modulates fear learning as well as amygdaloid synaptic plasticity. EMBO J. 2006;25:2867-77 pubmed
    ..The NR2B subunit of the NMDA receptor is tyrosine-phosphorylated in the brain, with Tyr-1472 its major phosphorylation site...
  28. Collins M, Husi H, Yu L, Brandon J, Anderson C, Blackstock W, et al. Molecular characterization and comparison of the components and multiprotein complexes in the postsynaptic proteome. J Neurochem. 2006;97 Suppl 1:16-23 pubmed
    ..against the NMDA receptor subunit NR1, and 170 by peptide-affinity purification of complexes with the C-terminus of NR2B. Together, the NR1 and NR2B complexes contain 186 proteins, collectively referred to as membrane-associated ..
  29. Halt A, Dallapiazza R, Zhou Y, Stein I, Qian H, Juntti S, et al. CaMKII binding to GluN2B is critical during memory consolidation. EMBO J. 2012;31:1203-16 pubmed publisher
    ..We generated mice with two point mutations that impair CaMKII binding to the NMDAR GluN2B subunit...
  30. Ebralidze A, Rossi D, Tonegawa S, Slater N. Modification of NMDA receptor channels and synaptic transmission by targeted disruption of the NR2C gene. J Neurosci. 1996;16:5014-25 pubmed
  31. Fontán Lozano A, Suárez Pereira I, Gonzalez Forero D, Carrión A. The A-current modulates learning via NMDA receptors containing the NR2B subunit. PLoS ONE. 2011;6:e24915 pubmed publisher
    ..that the facilitated learning induced by decreased I(A) requires the activation of NMDA receptors containing the NR2B subunit...
  32. Sprengel R, Suchanek B, Amico C, Brusa R, Burnashev N, Rozov A, et al. Importance of the intracellular domain of NR2 subunits for NMDA receptor function in vivo. Cell. 1998;92:279-89 pubmed
    ..Mice expressing the NR2B subunit in a C-terminally truncated form (NR2B(deltaC/deltaC) mice) die perinatally...
  33. Rönicke R, Mikhaylova M, Rönicke S, Meinhardt J, Schröder U, Fändrich M, et al. Early neuronal dysfunction by amyloid ? oligomers depends on activation of NR2B-containing NMDA receptors. Neurobiol Aging. 2011;32:2219-28 pubmed publisher
    ..Interestingly, all these effects can be blocked with the NR2B-containing NMDA-receptor antagonist ifenprodil or Ro 25-6981 suggesting that activation of downstream effectors of ..
  34. Bordji K, Becerril Ortega J, Nicole O, Buisson A. Activation of extrasynaptic, but not synaptic, NMDA receptors modifies amyloid precursor protein expression pattern and increases amyloid-ß production. J Neurosci. 2010;30:15927-42 pubmed publisher
    ..Altogether, these data suggest that a chronic activation of extrasynaptic NMDAR promotes amyloidogenic KPI-APP expression leading to neuronal A? release, representing a causal risk factor for developing AD...
  35. Setou M, Nakagawa T, Seog D, Hirokawa N. Kinesin superfamily motor protein KIF17 and mLin-10 in NMDA receptor-containing vesicle transport. Science. 2000;288:1796-802 pubmed
    Experiments with vesicles containing N-methyl-D-aspartate (NMDA) receptor 2B (NR2B subunit) show that they are transported along microtubules by KIF17, a neuron-specific molecular motor in neuronal dendrites...
  36. Tao Y, Rumbaugh G, Wang G, Petralia R, Zhao C, Kauer F, et al. Impaired NMDA receptor-mediated postsynaptic function and blunted NMDA receptor-dependent persistent pain in mice lacking postsynaptic density-93 protein. J Neurosci. 2003;23:6703-12 pubmed
    ..abundantly in spinal dorsal horn and forebrain, where it colocalizes and interacts with NMDAR subunits NR2A and NR2B. Targeted disruption of the PSD-93 gene reduces not only surface NR2A and NR2B expression but also NMDAR-mediated ..
  37. White T, Youngentob S. The effect of NMDA-NR2B receptor subunit over-expression on olfactory memory task performance in the mouse. Brain Res. 2004;1021:1-7 pubmed
    ..NMDA) receptor in the forebrain is thought to modulate some forms of memory formation, with the NR2B subunit being particularly relevant to this process...
  38. Tezuka T, Umemori H, Akiyama T, Nakanishi S, Yamamoto T. PSD-95 promotes Fyn-mediated tyrosine phosphorylation of the N-methyl-D-aspartate receptor subunit NR2A. Proc Natl Acad Sci U S A. 1999;96:435-40 pubmed
    ..These results suggest that PSD-95 is critical for regulation of NMDA receptor activity by Fyn and other Src-family PTKs, serving as a molecular scaffold for anchoring these PTKs to NR2A. ..
  39. Fernandez E, Collins M, Uren R, Kopanitsa M, Komiyama N, Croning M, et al. Targeted tandem affinity purification of PSD-95 recovers core postsynaptic complexes and schizophrenia susceptibility proteins. Mol Syst Biol. 2009;5:269 pubmed publisher
    ..This targeted TAP tagging strategy is generally applicable to mammalian proteomics and systems biology approaches to disease. ..
  40. Kutsuwada T, Sakimura K, Manabe T, Takayama C, Katakura N, Kushiya E, et al. Impairment of suckling response, trigeminal neuronal pattern formation, and hippocampal LTD in NMDA receptor epsilon 2 subunit mutant mice. Neuron. 1996;16:333-44 pubmed
    ..In the hippocampus of the mutant mice, synaptic NMDA responses and longterm depression were abolished. These results suggest that the epsilon 2 subunit plays an essential role in both neuronal pattern formation and synaptic plasticity. ..
  41. Astori S, Lüthi A. Synaptic plasticity at intrathalamic connections via CaV3.3 T-type Ca2+ channels and GluN2B-containing NMDA receptors. J Neurosci. 2013;33:624-30 pubmed publisher
    ..3 channels induced long-term potentiation at thalamoreticular inputs when coactivated with GluN2B-containing NMDA receptors, which are the dominant subtype at these synapses...
  42. Chang C, Lee C, Hou W, Lin M, Lai H, Chien C, et al. Type VI adenylyl cyclase negatively regulates GluN2B-mediated LTD and spatial reversal learning. Sci Rep. 2016;6:22529 pubmed publisher
    ..and N-terminus of AC6 (AC6N)-dependent elevation of CREB expression, and enhances the expression of GluN2B-containing NMDA receptors in hippocampal neurons...
  43. Corcoran K, Leaderbrand K, Radulovic J. Extinction of remotely acquired fear depends on an inhibitory NR2B/PKA pathway in the retrosplenial cortex. J Neurosci. 2013;33:19492-8 pubmed publisher
    ..pathways in the in the retrosplenial cortex, we demonstrated that extinction of remote fear uniquely required NR2B-mediated downregulation of the cAMP-dependent protein kinase (PKA)/cAMP response element-binding protein pathway...
  44. Jalan Sakrikar N, Bartlett R, Baucum A, Colbran R. Substrate-selective and calcium-independent activation of CaMKII by ?-actinin. J Biol Chem. 2012;287:15275-83 pubmed publisher
    ..In intact cells, ?-actinin selectively stabilizes CaMKII association with GluN2B-containing glutamate receptors and enhances phosphorylation of Ser-1303 in GluN2B, but inhibits CaMKII ..
  45. Zhao D, Liu D, Chen X, Wang K, Zhang A, Kang J, et al. Prenatal stress disturbs hippocampal KIF17 and NR2B in spatial cognition in male offspring. J Neurosci Res. 2013;91:535-44 pubmed publisher
    ..KIF17 (kinesin superfamily motor protein 17), which specifically transports and regulates the NMDA receptor subunit NR2B in hippocampal neurons...
  46. Hall B, Ripley B, Ghosh A. NR2B signaling regulates the development of synaptic AMPA receptor current. J Neurosci. 2007;27:13446-56 pubmed
    ..Developing cortical synapses are dominated by NMDA receptors (NMDARs) containing NR2B subunits and are characterized by a low ratio of AMPA/NMDA receptor-mediated current...
  47. Hu X, Cheng X, Cai L, Tan G, Xu L, Feng X, et al. Conditional deletion of NRSF in forebrain neurons accelerates epileptogenesis in the kindling model. Cereb Cortex. 2011;21:2158-65 pubmed publisher
    ..Furthermore, the derepression of BDNF was associated by activation of PLC? and PI(3)K signaling pathways. These findings indicate that NRSF functions as an intrinsic repressor of limbic epileptogenesis. ..
  48. Hu M, Sun Y, Zhou Q, Chen L, Hu Y, Luo C, et al. Negative regulation of neurogenesis and spatial memory by NR2B-containing NMDA receptors. J Neurochem. 2008;106:1900-13 pubmed publisher
    ..In adult forebrain regions such as the hippocampus and cortex, only NR2A and NR2B subunits are available to form the receptor complex with NR1 subunit...
  49. O Hara B, Andretic R, Heller H, Carter D, Kilduff T. GABAA, GABAC, and NMDA receptor subunit expression in the suprachiasmatic nucleus and other brain regions. Brain Res Mol Brain Res. 1995;28:239-50 pubmed
    ..Among the NMDA receptor subunits, NR1 was most highly expressed in the SCN followed in order of abundance by NR2B, NR2A, NR2C and NR2D...
  50. Okada H, Miyakawa N, Mori H, Mishina M, Miyamoto Y, Hisatsune T. NMDA receptors in cortical development are essential for the generation of coordinated increases in [Ca2+](i) in "neuronal domains". Cereb Cortex. 2003;13:749-57 pubmed
    ..In this study, we utilized the N-methyl-D-aspartate (NMDA)-type glutamate receptor epsilon 2 (GluR epsilon 2/NR2B)(-/-) mouse, which does not possess any functional NMDA receptors in the developing neocortex, and showed that NMDA ..
  51. Mayadevi M, Praseeda M, Kumar K, Omkumar R. Sequence determinants on the NR2A and NR2B subunits of NMDA receptor responsible for specificity of phosphorylation by CaMKII. Biochim Biophys Acta. 2002;1598:40-5 pubmed
    ..CaMKII binds to the NR2B subunit of NMDAR in more than one mode, a stable association involving a noncatalytic site on CaMKII and an enzyme-..
  52. Lu H, Gonzalez E, Crair M. Barrel cortex critical period plasticity is independent of changes in NMDA receptor subunit composition. Neuron. 2001;32:619-34 pubmed
    ..Thalamocortical synaptic plasticity in the mouse is dependent on NMDARs containing the NR2B subunit, which are the dominant form during the "critical period" window for plasticity...
  53. Takahashi E, Niimi K, Itakura C. Enhanced CaMKII activity and spatial cognitive function in SAMP6 mice. Behav Neurosci. 2009;123:527-32 pubmed publisher
    Senescence-accelerated mouse prone 6 (SAMP6) mice exhibit increased expression of NMDA receptor NR2B subunit (NR2B) and improved short-term memory compared with senescence-accelerated mouse resistance 1 (SAMR1) mice...
  54. Wang T, Ding C, Wang G, Luo S, Lin Y, Ruan Y, et al. Identification of Tbr-1/CASK complex target genes in neurons. J Neurochem. 2004;91:1483-92 pubmed
    ..of Tbr-1 and CASK-enhanced promoter activities of some of these putative target genes, including NMDAR subunit 2b (NR2b), glycine transporter, interleukin 7 receptor (IL-7R) and OX-2...
  55. Rauner C, Köhr G. Triheteromeric NR1/NR2A/NR2B receptors constitute the major N-methyl-D-aspartate receptor population in adult hippocampal synapses. J Biol Chem. 2011;286:7558-66 pubmed publisher
    ..synaptic NMDARs in postnatal principal forebrain neurons is typically attributed to diheteromeric NR1/NR2A and NR1/NR2B receptors, despite compelling evidence for triheteromeric NR1/NR2A/NR2B receptors...
  56. Qiang M, Denny A, Lieu M, Carreon S, Li J. Histone H3K9 modifications are a local chromatin event involved in ethanol-induced neuroadaptation of the NR2B gene. Epigenetics. 2011;6:1095-104 pubmed publisher
    Expression of the NMDA receptor 2B (NR2B) gene is upregulated following chronic intermittent ethanol (CIE) treatment and withdrawal, which underlies behavioral alterations in addiction...
  57. Renzi M, Farrant M, Cull Candy S. Climbing-fibre activation of NMDA receptors in Purkinje cells of adult mice. J Physiol. 2007;585:91-101 pubmed
    ..NMDA receptor subtypes are indeed expressed in Purkinje cells of young and adult mice; in the adult, both NR2A- and NR2B-containing subtypes are present...
  58. Aoki C, Sherpa A. Making of a Synapse: Recurrent Roles of Drebrin A at Excitatory Synapses Throughout Life. Adv Exp Med Biol. 2017;1006:119-139 pubmed publisher
    ..Drebrin A can be found co-clustering with NR2B-containing NMDARs at the plasma membrane, while NR2A-containing NMDARs co-traffic into the spine cytoplasm but do ..
  59. Liu H, Li Y, Wang Y, Wang X, An X, Wang S, et al. The distinct role of NR2B subunit in the enhancement of visual plasticity in adulthood. Mol Brain. 2015;8:49 pubmed publisher
    ..Blockade of NR2B activity in both the induction and expression periods of plasticity prevented this reinstatement...
  60. Zhu X, Dong J, Shen K, Bai Y, Zhang Y, Lv X, et al. NMDA receptor NR2B subunits contribute to PTZ-kindling-induced hippocampal astrocytosis and oxidative stress. Brain Res Bull. 2015;114:70-8 pubmed publisher
    ..The present study investigated the effect of NMDA receptor NR2B subunits on pentylenetetrazole (PTZ)-kindling-induced pathological and biochemical events in mice...
  61. Tackenberg C, Grinschgl S, Trutzel A, Santuccione A, Frey M, Konietzko U, et al. NMDA receptor subunit composition determines beta-amyloid-induced neurodegeneration and synaptic loss. Cell Death Dis. 2013;4:e608 pubmed publisher
    ..Inhibition of NR2B-containing NMDARs abolished A?-induced hTau phosphorylation and toxicity by preventing GSK-3? activation but did ..
  62. Guillaud L, Setou M, Hirokawa N. KIF17 dynamics and regulation of NR2B trafficking in hippocampal neurons. J Neurosci. 2003;23:131-40 pubmed
    ..superfamily proteins, has been proposed to bind in vitro to a protein complex containing mLin10 (Mint1/X11) and the NR2B subunit of the NMDA receptors (NMDARs)...
  63. Kazdoba T, Sunnen C, Crowell B, Lee G, Anderson A, D ARCANGELO G. Development and characterization of NEX- Pten, a novel forebrain excitatory neuron-specific knockout mouse. Dev Neurosci. 2012;34:198-209 pubmed
    ..Analysis of the neonatal cerebral cortex further identified molecular defects resulting from Pten deletion that likely affect several aspects of neuronal development and excitability. ..
  64. Fontaine R, Olivier P, Massonneau V, Leroux P, Degos V, Lebon S, et al. Vulnerability of white matter towards antenatal hypoxia is linked to a species-dependent regulation of glutamate receptor subunits. Proc Natl Acad Sci U S A. 2008;105:16779-84 pubmed publisher
    ..None of the glutamate-receptor subunits was down-regulated in the hypoxic rat pups. NR2B was the only NMDA-receptor subunit that was down-regulated in hypoxic mice but not in hypoxic rat on P1...
  65. Notwell J, Heavner W, Darbandi S, Katzman S, McKenna W, Ortiz Londono C, et al. TBR1 regulates autism risk genes in the developing neocortex. Genome Res. 2016;26:1013-22 pubmed publisher
    ..Our findings highlight a TBR1-regulated network of ASD genes in the developing neocortex that are relatively intolerant to LoF mutations, indicating that these genes may play critical roles in normal cortical development. ..
  66. Hu R, Wei P, Jin L, Zheng T, Chen W, Liu X, et al. Overexpression of EphB2 in hippocampus rescues impaired NMDA receptors trafficking and cognitive dysfunction in Alzheimer model. Cell Death Dis. 2017;8:e2717 pubmed publisher
    ..Phosphorylation and surface expression of GluN2B-containing NMDA receptors were also improved...