Grin2a

Summary

Gene Symbol: Grin2a
Description: glutamate receptor, ionotropic, NMDA2A (epsilon 1)
Alias: GluN2A, GluRepsilon1, NMDAR2A, NR2A, glutamate receptor ionotropic, NMDA 2A, N-methyl D-aspartate receptor subtype 2A, glutamate [NMDA] receptor subunit epsilon-1
Species: mouse
Products:     Grin2a

Top Publications

  1. Sato Y, Kobayashi E, Murayama T, Mishina M, Seo N. Effect of N-methyl-D-aspartate receptor epsilon1 subunit gene disruption of the action of general anesthetic drugs in mice. Anesthesiology. 2005;102:557-61 pubmed
  2. Townsend M, Yoshii A, Mishina M, Constantine Paton M. Developmental loss of miniature N-methyl-D-aspartate receptor currents in NR2A knockout mice. Proc Natl Acad Sci U S A. 2003;100:1340-5 pubmed
    ..NMDAR), long implicated in developmental plasticity, shows decay time kinetics that shorten postnatally as NR2A subunits are added to the receptor. Neither the mechanism nor immediate effect of this change is known...
  3. Ikeda K, Nagasawa M, Mori H, Araki K, Sakimura K, Watanabe M, et al. Cloning and expression of the epsilon 4 subunit of the NMDA receptor channel. FEBS Lett. 1992;313:34-8 pubmed
    ..The epsilon 4 subunit is thus distinct in functional properties from the epsilon 1, epsilon 2 and epsilon 3 subunits, and contributes further diversity of the NMDA receptor channel. ..
  4. Kitamura T, Mishina M, Sugiyama H. Enhancement of neurogenesis by running wheel exercises is suppressed in mice lacking NMDA receptor epsilon 1 subunit. Neurosci Res. 2003;47:55-63 pubmed
    ..These results suggest that the wheel exercise may activate NMDA receptors in the hippocampus, which in turn may enhance BDNF production and neurogenesis. ..
  5. Kiyama Y, Manabe T, Sakimura K, Kawakami F, Mori H, Mishina M. Increased thresholds for long-term potentiation and contextual learning in mice lacking the NMDA-type glutamate receptor epsilon1 subunit. J Neurosci. 1998;18:6704-12 pubmed
    ..The mutant mice lacking the GluRepsilon1 subunit exhibited a reduction in hippocampal long-term potentiation (LTP), but a stronger tetanic stimulation ..
  6. Berberich S, Jensen V, Hvalby Ø, Seeburg P, Köhr G. The role of NMDAR subtypes and charge transfer during hippocampal LTP induction. Neuropharmacology. 2007;52:77-86 pubmed
    ..For high frequency afferent stimulation (HFS), we found that genetic impairment of NR2A or pharmacological block of NR2A- or NR2B-type NMDARs can reduce field LTP...
  7. Van de Ven T, VanDongen H, VanDongen A. The nonkinase phorbol ester receptor alpha 1-chimerin binds the NMDA receptor NR2A subunit and regulates dendritic spine density. J Neurosci. 2005;25:9488-96 pubmed
    ..phorbol ester receptor alpha1-chimerin is present in dendrites and spines, where it binds to the NMDA receptor NR2A subunit in a phorbol ester-dependent manner...
  8. Meguro H, Mori H, Araki K, Kushiya E, Kutsuwada T, Yamazaki M, et al. Functional characterization of a heteromeric NMDA receptor channel expressed from cloned cDNAs. Nature. 1992;357:70-4 pubmed
    ..Furthermore, the heteromeric NMDA receptor channel can be activated by glycine alone. ..
  9. Ebralidze A, Rossi D, Tonegawa S, Slater N. Modification of NMDA receptor channels and synaptic transmission by targeted disruption of the NR2C gene. J Neurosci. 1996;16:5014-25 pubmed
  10. Ryan T, Kopanitsa M, Indersmitten T, Nithianantharajah J, Afinowi N, Pettit C, et al. Evolution of GluN2A/B cytoplasmic domains diversified vertebrate synaptic plasticity and behavior. Nat Neurosci. 2013;16:25-32 pubmed publisher
    ..shared ancestral functions and diversified subunit-specific functions, we exchanged the exons encoding the GluN2A (also known as Grin2a) and GluN2B (also known as Grin2b) CTDs in two knock-in mice and analyzed the mice's ..

Detail Information

Publications90

  1. Sato Y, Kobayashi E, Murayama T, Mishina M, Seo N. Effect of N-methyl-D-aspartate receptor epsilon1 subunit gene disruption of the action of general anesthetic drugs in mice. Anesthesiology. 2005;102:557-61 pubmed
  2. Townsend M, Yoshii A, Mishina M, Constantine Paton M. Developmental loss of miniature N-methyl-D-aspartate receptor currents in NR2A knockout mice. Proc Natl Acad Sci U S A. 2003;100:1340-5 pubmed
    ..NMDAR), long implicated in developmental plasticity, shows decay time kinetics that shorten postnatally as NR2A subunits are added to the receptor. Neither the mechanism nor immediate effect of this change is known...
  3. Ikeda K, Nagasawa M, Mori H, Araki K, Sakimura K, Watanabe M, et al. Cloning and expression of the epsilon 4 subunit of the NMDA receptor channel. FEBS Lett. 1992;313:34-8 pubmed
    ..The epsilon 4 subunit is thus distinct in functional properties from the epsilon 1, epsilon 2 and epsilon 3 subunits, and contributes further diversity of the NMDA receptor channel. ..
  4. Kitamura T, Mishina M, Sugiyama H. Enhancement of neurogenesis by running wheel exercises is suppressed in mice lacking NMDA receptor epsilon 1 subunit. Neurosci Res. 2003;47:55-63 pubmed
    ..These results suggest that the wheel exercise may activate NMDA receptors in the hippocampus, which in turn may enhance BDNF production and neurogenesis. ..
  5. Kiyama Y, Manabe T, Sakimura K, Kawakami F, Mori H, Mishina M. Increased thresholds for long-term potentiation and contextual learning in mice lacking the NMDA-type glutamate receptor epsilon1 subunit. J Neurosci. 1998;18:6704-12 pubmed
    ..The mutant mice lacking the GluRepsilon1 subunit exhibited a reduction in hippocampal long-term potentiation (LTP), but a stronger tetanic stimulation ..
  6. Berberich S, Jensen V, Hvalby Ø, Seeburg P, Köhr G. The role of NMDAR subtypes and charge transfer during hippocampal LTP induction. Neuropharmacology. 2007;52:77-86 pubmed
    ..For high frequency afferent stimulation (HFS), we found that genetic impairment of NR2A or pharmacological block of NR2A- or NR2B-type NMDARs can reduce field LTP...
  7. Van de Ven T, VanDongen H, VanDongen A. The nonkinase phorbol ester receptor alpha 1-chimerin binds the NMDA receptor NR2A subunit and regulates dendritic spine density. J Neurosci. 2005;25:9488-96 pubmed
    ..phorbol ester receptor alpha1-chimerin is present in dendrites and spines, where it binds to the NMDA receptor NR2A subunit in a phorbol ester-dependent manner...
  8. Meguro H, Mori H, Araki K, Kushiya E, Kutsuwada T, Yamazaki M, et al. Functional characterization of a heteromeric NMDA receptor channel expressed from cloned cDNAs. Nature. 1992;357:70-4 pubmed
    ..Furthermore, the heteromeric NMDA receptor channel can be activated by glycine alone. ..
  9. Ebralidze A, Rossi D, Tonegawa S, Slater N. Modification of NMDA receptor channels and synaptic transmission by targeted disruption of the NR2C gene. J Neurosci. 1996;16:5014-25 pubmed
  10. Ryan T, Kopanitsa M, Indersmitten T, Nithianantharajah J, Afinowi N, Pettit C, et al. Evolution of GluN2A/B cytoplasmic domains diversified vertebrate synaptic plasticity and behavior. Nat Neurosci. 2013;16:25-32 pubmed publisher
    ..shared ancestral functions and diversified subunit-specific functions, we exchanged the exons encoding the GluN2A (also known as Grin2a) and GluN2B (also known as Grin2b) CTDs in two knock-in mice and analyzed the mice's ..
  11. Miyamoto Y, Yamada K, Nagai T, Mori H, Mishina M, Furukawa H, et al. Behavioural adaptations to addictive drugs in mice lacking the NMDA receptor epsilon1 subunit. Eur J Neurosci. 2004;19:151-8 pubmed
    ..formed by assembly of the GluRzeta subunit (called NR1 in rats) with any one of four GluRepsilon subunits (GluRepsilon1-4; NR2A-D), play an important role in excitatory neurotransmission, synaptic plasticity and brain development...
  12. Fleischmann A, Hvalby O, Jensen V, Strekalova T, Zacher C, Layer L, et al. Impaired long-term memory and NR2A-type NMDA receptor-dependent synaptic plasticity in mice lacking c-Fos in the CNS. J Neurosci. 2003;23:9116-22 pubmed
    ..This blockade was compensated in wild-type mice by NR2A-type NMDA receptor-activated signaling pathways, thus indicating that these pathways are compromised in c-..
  13. Gray J, Shi Y, Usui H, During M, Sakimura K, Nicoll R. Distinct modes of AMPA receptor suppression at developing synapses by GluN2A and GluN2B: single-cell NMDA receptor subunit deletion in vivo. Neuron. 2011;71:1085-101 pubmed publisher
    ..switch in synaptic N-Methyl-D-aspartate (NMDA) receptor subunit composition from predominantly GluN2B to GluN2A, though the precise role of this switch remains unknown...
  14. Akashi K, Kakizaki T, Kamiya H, Fukaya M, Yamasaki M, Abe M, et al. NMDA receptor GluN2B (GluR epsilon 2/NR2B) subunit is crucial for channel function, postsynaptic macromolecular organization, and actin cytoskeleton at hippocampal CA3 synapses. J Neurosci. 2009;29:10869-82 pubmed publisher
    ..By immunohistochemistry, GluN2B disappeared and GluN1 (GluRzeta1/NR1) was moderately reduced, whereas GluN2A (GluRepsilon1/NR2A) and postsynaptic density-95 (PSD-95) were unaltered in the mutant CA3...
  15. Berberich S, Punnakkal P, Jensen V, Pawlak V, Seeburg P, Hvalby Ø, et al. Lack of NMDA receptor subtype selectivity for hippocampal long-term potentiation. J Neurosci. 2005;25:6907-10 pubmed
    NMDA receptor (NMDAR) 2A (NR2A)- and NR2B-type NMDARs coexist in synapses of CA1 pyramidal cells...
  16. Watanabe M, Inoue Y, Sakimura K, Mishina M. Developmental changes in distribution of NMDA receptor channel subunit mRNAs. Neuroreport. 1992;3:1138-40 pubmed
    ..In contrast, the zeta 1 subunit mRNA distributes ubiquitously in the brain throughout development. These findings suggest that changes in the subunit composition of the NMDA receptor channel take place during brain development. ..
  17. Inoue M, Mishina M, Ueda H. Locus-specific rescue of GluRepsilon1 NMDA receptors in mutant mice identifies the brain regions important for morphine tolerance and dependence. J Neurosci. 2003;23:6529-36 pubmed
    ..subunit of the NMDA receptor using mice lacking the gene encoding epsilon1 subunit of the NMDA receptor (GluRepsilon1-/- mice)...
  18. Bannerman D, Niewoehner B, Lyon L, Romberg C, Schmitt W, Taylor A, et al. NMDA receptor subunit NR2A is required for rapidly acquired spatial working memory but not incremental spatial reference memory. J Neurosci. 2008;28:3623-30 pubmed publisher
    NMDA receptors (NMDARs) containing NR2A (epsilon1) subunits are key contributors to hippocampal long-term potentiation (LTP) induction in adult animals and have therefore been widely implicated in hippocampus-dependent spatial learning...
  19. Sakimura K, Kutsuwada T, Ito I, Manabe T, Takayama C, Kushiya E, et al. Reduced hippocampal LTP and spatial learning in mice lacking NMDA receptor epsilon 1 subunit. Nature. 1995;373:151-5 pubmed
    ..On the basis of the Mg2+ sensitivity and expression patterns, we have proposed that the epsilon 1 (NR2A) and epsilon 2 (NR2B) subunits play a role in synaptic plasticity...
  20. Kadotani H, Hirano T, Masugi M, Nakamura K, Nakao K, Katsuki M, et al. Motor discoordination results from combined gene disruption of the NMDA receptor NR2A and NR2C subunits, but not from single disruption of the NR2A or NR2C subunit. J Neurosci. 1996;16:7859-67 pubmed
    ..The NR1 subunit possesses all properties of the NMDA receptor-channel complex, whereas four NR2 subunits (NR2A-2D) potentiate and differentiate NMDA receptor responses by heteromeric assemblies with NR1...
  21. Tezuka T, Umemori H, Akiyama T, Nakanishi S, Yamamoto T. PSD-95 promotes Fyn-mediated tyrosine phosphorylation of the N-methyl-D-aspartate receptor subunit NR2A. Proc Natl Acad Sci U S A. 1999;96:435-40 pubmed
    ..Results showed that tyrosine phosphorylation of NR2A, one of the NMDA receptor subunits, was reduced in fyn-mutant mice...
  22. Faust T, Chang E, Kowal C, Berlin R, Gazaryan I, Bertini E, et al. Neurotoxic lupus autoantibodies alter brain function through two distinct mechanisms. Proc Natl Acad Sci U S A. 2010;107:18569-74 pubmed publisher
    ..We have studied lupus AAbs that bind dsDNA and cross-react with the NR2A and NR2B subunits of the NMDA receptor (NMDAR)...
  23. Miyamoto Y, Yamada K, Noda Y, Mori H, Mishina M, Nabeshima T. Hyperfunction of dopaminergic and serotonergic neuronal systems in mice lacking the NMDA receptor epsilon1 subunit. J Neurosci. 2001;21:750-7 pubmed
    ..channels, are composed by assembly of the GluRzeta subunit (NR1) with any one of four GluRepsilon subunits (GluRepsilon1-4; NR2A-D). In the present study, we investigated neuronal functions in mice lacking the GluRepsilon1 subunit...
  24. Wong R, Setou M, Teng J, Takei Y, Hirokawa N. Overexpression of motor protein KIF17 enhances spatial and working memory in transgenic mice. Proc Natl Acad Sci U S A. 2002;99:14500-5 pubmed
    ..Our results suggest that the motor protein KIF17 contributes to neuronal events required for learning and memory by trafficking fundamental N-methyl-d-aspartate-type glutamate receptors. ..
  25. Sprengel R, Suchanek B, Amico C, Brusa R, Burnashev N, Rozov A, et al. Importance of the intracellular domain of NR2 subunits for NMDA receptor function in vivo. Cell. 1998;92:279-89 pubmed
    ..Mice expressing the NR2B subunit in a C-terminally truncated form (NR2B(deltaC/deltaC) mice) die perinatally. NR2A(deltaC/deltaC) mice are viable but exhibit impaired synaptic plasticity and contextual memory...
  26. Bordji K, Becerril Ortega J, Nicole O, Buisson A. Activation of extrasynaptic, but not synaptic, NMDA receptors modifies amyloid precursor protein expression pattern and increases amyloid-ß production. J Neurosci. 2010;30:15927-42 pubmed publisher
    ..Altogether, these data suggest that a chronic activation of extrasynaptic NMDAR promotes amyloidogenic KPI-APP expression leading to neuronal A? release, representing a causal risk factor for developing AD...
  27. Köhr G, Jensen V, Koester H, Mihaljevic A, Utvik J, Kvello A, et al. Intracellular domains of NMDA receptor subtypes are determinants for long-term potentiation induction. J Neurosci. 2003;23:10791-9 pubmed
    ..CA3-to-CA1 synapses of adult mice, different NMDAR subtypes with distinct functionality assemble from NR1 with NR2A and/or NR2B subunits...
  28. Weitlauf C, Honse Y, Auberson Y, Mishina M, Lovinger D, Winder D. Activation of NR2A-containing NMDA receptors is not obligatory for NMDA receptor-dependent long-term potentiation. J Neurosci. 2005;25:8386-90 pubmed
    ..One particular NR2 subunit, NR2A (NRepsilon1), has been proposed to play an integral role in LTP induction in the hippocampus and cortex...
  29. Kutsuwada T, Kashiwabuchi N, Mori H, Sakimura K, Kushiya E, Araki K, et al. Molecular diversity of the NMDA receptor channel. Nature. 1992;358:36-41 pubmed
    ..These findings suggest that the molecular diversity of the epsilon subunit family underlies the functional heterogeneity of the NMDA receptor channel. ..
  30. Tao Y, Rumbaugh G, Wang G, Petralia R, Zhao C, Kauer F, et al. Impaired NMDA receptor-mediated postsynaptic function and blunted NMDA receptor-dependent persistent pain in mice lacking postsynaptic density-93 protein. J Neurosci. 2003;23:6703-12 pubmed
    ..is expressed abundantly in spinal dorsal horn and forebrain, where it colocalizes and interacts with NMDAR subunits NR2A and NR2B...
  31. Ventruti A, Kazdoba T, Niu S, D ARCANGELO G. Reelin deficiency causes specific defects in the molecular composition of the synapses in the adult brain. Neuroscience. 2011;189:32-42 pubmed publisher
    ..Decreased levels of postsynaptic density-95 (PSD-95), the N-methyl d-aspartate (NMDA) receptor subunits NR2A and NR2B, and the phosphatase PTEN were found specifically in the postsynaptic density fraction obtained from these ..
  32. Miyazaki T, Hashimoto K, Uda A, Sakagami H, Nakamura Y, Saito S, et al. Disturbance of cerebellar synaptic maturation in mutant mice lacking BSRPs, a novel brain-specific receptor-like protein family. FEBS Lett. 2006;580:4057-64 pubmed
    ..Because cerebellar maturation and plasticity require metabotropic glutamate receptor signaling and resulting PKC activation, BSRPs are likely involved in ER functions supporting PKCalpha activation in PCs. ..
  33. Chen Z, Duan R, Zhu Y, Folkesson R, Albanese C, Winblad B, et al. Increased cyclin E expression may obviate the role of cyclin D1 during brain development in cyclin D1 knockout mice. J Neurochem. 2005;92:1281-4 pubmed
    ..The data indicate that enhanced cyclin E protein expression in cyclin D1 KO mice may obviate the role of cyclin D1 and contribute to the normal brain development of cyclin D1 KO mice. ..
  34. Jelitai M, Schlett K, Varju P, Eisel U, Madarász E. Regulated appearance of NMDA receptor subunits and channel functions during in vitro neuronal differentiation. J Neurobiol. 2002;51:54-65 pubmed
    ..b>NR2A, NR2B, and NR2D subunit transcripts were present in both nondifferentiated and neuronally differentiated cultures, ..
  35. Park C, Elgersma Y, Grant S, Morrison J. alpha-Isoform of calcium-calmodulin-dependent protein kinase II and postsynaptic density protein 95 differentially regulate synaptic expression of NR2A- and NR2B-containing N-methyl-d-aspartate receptors in hippocampus. Neuroscience. 2008;151:43-55 pubmed
    ..regions of the synapse without affecting changes in the localization of N-methyl-d-aspartate receptor subunit 2A (NR2A) subunits...
  36. Brigman J, Feyder M, Saksida L, Bussey T, Mishina M, Holmes A. Impaired discrimination learning in mice lacking the NMDA receptor NR2A subunit. Learn Mem. 2008;15:50-4 pubmed publisher
    ..We used a touchscreen system to assess NR2A subunit knockout mice (KO) for (1) pairwise visual discrimination and reversal learning and (2) acquisition and ..
  37. Butcher A, Torrecilla I, Young K, Kong K, Mistry S, Bottrill A, et al. N-methyl-D-aspartate receptors mediate the phosphorylation and desensitization of muscarinic receptors in cerebellar granule neurons. J Biol Chem. 2009;284:17147-56 pubmed publisher
  38. Mayadevi M, Praseeda M, Kumar K, Omkumar R. Sequence determinants on the NR2A and NR2B subunits of NMDA receptor responsible for specificity of phosphorylation by CaMKII. Biochim Biophys Acta. 2002;1598:40-5 pubmed
    ..However, CaMKII shows decreased affinity towards the closely related NR2A subunit due to an -Ile-Asn- motif present as a natural insertion in the analogous sequence on NR2A.
  39. O Hara B, Andretic R, Heller H, Carter D, Kilduff T. GABAA, GABAC, and NMDA receptor subunit expression in the suprachiasmatic nucleus and other brain regions. Brain Res Mol Brain Res. 1995;28:239-50 pubmed
    ..Among the NMDA receptor subunits, NR1 was most highly expressed in the SCN followed in order of abundance by NR2B, NR2A, NR2C and NR2D...
  40. Herwerth M, Jensen V, Novak M, Konopka W, Hvalby O, Köhr G. D4 dopamine receptors modulate NR2B NMDA receptors and LTP in stratum oriens of hippocampal CA1. Cereb Cortex. 2012;22:1786-98 pubmed publisher
    ..A similar dopaminergic modulation of both NMDA EPSCs and LTP was also observed in mice constitutively lacking NR2A but was absent in mice lacking NR2B in principal forebrain neurons...
  41. Minami T, Sugatani J, Sakimura K, Abe M, Mishina M, Ito S. Absence of prostaglandin E2-induced hyperalgesia in NMDA receptor epsilon subunit knockout mice. Br J Pharmacol. 1997;120:1522-6 pubmed
    ..5. These results demonstrate that the pathways leading to hyperalgesia are different between PGD2 and PGE2, and that both epsilon 1 and epsilon 4 subunits of the NMDA receptor are involved in the PGE2-induced hyperalgesia. ..
  42. Takano H, Onodera O, Tanaka H, Mori H, Sakimura K, Hori T, et al. Chromosomal localization of the epsilon 1, epsilon 3 and zeta 1 subunit genes of the human NMDA receptor channel. Biochem Biophys Res Commun. 1993;197:922-6 pubmed
    ..By the fluorescence in situ hybridization, we mapped the genes for the epsilon 1, epsilon 3 and zeta 1 subunits of the human NMDA receptor channel to chromosomes 16p13, 17q25 and 9q34, respectively. ..
  43. Lu H, Gonzalez E, Crair M. Barrel cortex critical period plasticity is independent of changes in NMDA receptor subunit composition. Neuron. 2001;32:619-34 pubmed
    ..Near the end of the critical period there is a gradual increase in the contribution of NR2A subunits that happens in parallel to changes in NMDAR-mediated current kinetics...
  44. Luo J, Fu Z, Losi G, Kim B, Prybylowski K, Vissel B, et al. Functional expression of distinct NMDA channel subunits tagged with green fluorescent protein in hippocampal neurons in culture. Neuropharmacology. 2002;42:306-18 pubmed
    We generated expression vectors for N-terminally green fluorescent protein -tagged NR2A and NR2B subunits (GFP-NR2A and GFP-NR2B)...
  45. Minami T, Matsumura S, Okuda Ashitaka E, Shimamoto K, Sakimura K, Mishina M, et al. Characterization of the glutamatergic system for induction and maintenance of allodynia. Brain Res. 2001;895:178-85 pubmed
    ..were observed in NMDA receptor epsilon 4 (NR2D) subunit knockout (GluR epsilon 4(-/-)) mice, but not in epsilon 1 (NR2A) subunit knockout (GluR epsilon 1(-/-)) mice...
  46. Kitamura T, Sugiyama H. Running wheel exercises accelerate neuronal turnover in mouse dentate gyrus. Neurosci Res. 2006;56:45-52 pubmed
    ..These results suggest that running wheel exercises accelerate neuronal turnover in mouse dentate gyrus, through the activation of NMDA receptors. ..
  47. Fagiolini M, Katagiri H, Miyamoto H, Mori H, Grant S, Mishina M, et al. Separable features of visual cortical plasticity revealed by N-methyl-D-aspartate receptor 2A signaling. Proc Natl Acad Sci U S A. 2003;100:2854-9 pubmed
    ..The shortening of N-methyl-d-aspartate (NMDA) receptor currents by 2A subunit (NR2A) insertion has been proposed to delimit the critical period for experience-dependent refinement of circuits in ..
  48. Ohno T, Maeda H, Murabe N, Kamiyama T, Yoshioka N, Mishina M, et al. Specific involvement of postsynaptic GluN2B-containing NMDA receptors in the developmental elimination of corticospinal synapses. Proc Natl Acad Sci U S A. 2010;107:15252-7 pubmed publisher
    The GluN2B (GluRepsilon2/NR2B) and GluN2A (GluRepsilon1/NR2A) NMDA receptor (NMDAR) subtypes have been differentially implicated in activity-dependent synaptic plasticity...
  49. Vasuta C, Caunt C, James R, Samadi S, Schibuk E, Kannangara T, et al. Effects of exercise on NMDA receptor subunit contributions to bidirectional synaptic plasticity in the mouse dentate gyrus. Hippocampus. 2007;17:1201-8 pubmed
    ..NVP-AAM077, an antagonist with a higher preference for NR2A subunits over NR2B subunits, blocked LTP in slices from Runners and produced a slight depression in Control animals...
  50. Müller T, Albrecht D, Gebhardt C. Both NR2A and NR2B subunits of the NMDA receptor are critical for long-term potentiation and long-term depression in the lateral amygdala of horizontal slices of adult mice. Learn Mem. 2009;16:395-405 pubmed publisher
    ..In the LA, NR2A- and NR2B-type NMDRs coexist in synapses of LA projection neurons...
  51. Zhang Z, Sun Q. Development of NMDA NR2 subunits and their roles in critical period maturation of neocortical GABAergic interneurons. Dev Neurobiol. 2011;71:221-45 pubmed publisher
    ..preCP group. (4) Using subunit-specific antagonists, we found a postnatal shift in NR2 composition towards more NR2A mediated EPSCs(NMDAR) ...
  52. Qin X, Jiang Y, Tse Y, Wang Y, Wong T, Paudel H. Early Growth Response 1 (Egr-1) Regulates N-Methyl-d-aspartate Receptor (NMDAR)-dependent Transcription of PSD-95 and α-Amino-3-hydroxy-5-methyl-4-isoxazole Propionic Acid Receptor (AMPAR) Trafficking in Hippocampal Primary Neurons. J Biol Chem. 2015;290:29603-16 pubmed publisher
    ..Our data indicate that Egr-1 is involved in NMDAR-mediated PSD-95 down-regulation and AMPAR endocytosis, a process important in the expression of long term depression. ..
  53. HOE H, Pocivavsek A, Chakraborty G, Fu Z, Vicini S, Ehlers M, et al. Apolipoprotein E receptor 2 interactions with the N-methyl-D-aspartate receptor. J Biol Chem. 2006;281:3425-31 pubmed
    ..We also found that the PDZ2 domain of PSD95 interacted with the NR2A and NR2B subunits of NMDA receptors...
  54. Saura C, Choi S, Beglopoulos V, Malkani S, Zhang D, Shankaranarayana Rao B, et al. Loss of presenilin function causes impairments of memory and synaptic plasticity followed by age-dependent neurodegeneration. Neuron. 2004;42:23-36 pubmed
    ..These results define essential roles and molecular targets of presenilins in synaptic plasticity, learning and memory, and neuronal survival in the adult cerebral cortex. ..
  55. Hu X, Follesa P, Ticku M. Chronic ethanol treatment produces a selective upregulation of the NMDA receptor subunit gene expression in mammalian cultured cortical neurons. Brain Res Mol Brain Res. 1996;36:211-8 pubmed
    ..The altered NMDA receptor gene expression may be responsible for the observed upregulation of the NMDA receptor binding and function in the cortical neurons following chronic ethanol exposure. ..
  56. Cao Z, Liu L, Lickey M, Graves A, Pham T, Gordon B. Virally mediated knock-down of NR2 subunits ipsilateral to the deprived eye blocks ocular dominance plasticity. Exp Brain Res. 2007;177:64-77 pubmed
    NMDA receptors (NMDARs) are important in developmental plasticity in the visual cortex. The NR2A and NR2B subunits of this receptor develop with different time courses, suggesting that they play different roles in plasticity...
  57. Takeuchi T, Kiyama Y, Nakamura K, Tsujita M, Matsuda I, Mori H, et al. Roles of the glutamate receptor epsilon2 and delta2 subunits in the potentiation and prepulse inhibition of the acoustic startle reflex. Eur J Neurosci. 2001;14:153-60 pubmed
  58. Ng D, Pitcher G, Szilard R, Sertié A, Kanisek M, Clapcote S, et al. Neto1 is a novel CUB-domain NMDA receptor-interacting protein required for synaptic plasticity and learning. PLoS Biol. 2009;7:e41 pubmed publisher
    ..transmembrane protein, is a novel component of the NMDAR complex critical for maintaining the abundance of NR2A-containing NMDARs in the postsynaptic density...
  59. Kishimoto Y, Kawahara S, Mori H, Mishina M, Kirino Y. Long-trace interval eyeblink conditioning is impaired in mutant mice lacking the NMDA receptor subunit epsilon 1. Eur J Neurosci. 2001;13:1221-7 pubmed
  60. Prickett T, Zerlanko B, Hill V, Gartner J, Qutob N, Jiang J, et al. Somatic mutation of GRIN2A in malignant melanoma results in loss of tumor suppressor activity via aberrant NMDAR complex formation. J Invest Dermatol. 2014;134:2390-2398 pubmed publisher
    ..Recently, we discovered the high prevalence of somatic mutations within one of the ionotropic glutamate receptors, GRIN2A, in malignant melanoma...
  61. Gao C, Gill M, Tronson N, Guedea A, Guzman Y, Huh K, et al. Hippocampal NMDA receptor subunits differentially regulate fear memory formation and neuronal signal propagation. Hippocampus. 2010;20:1072-82 pubmed publisher
    ..Here we demonstrate, using intrahippocampal injection of subunit-selective compounds, that the NR2A-preferring antagonist impaired contextual and trace fear conditioning as well as learning-induced increase of the ..
  62. Ito I, Sakimura K, Mishina M, Sugiyama H. Age-dependent reduction of hippocampal LTP in mice lacking N-methyl-D-aspartate receptor epsilon 1 subunit. Neurosci Lett. 1996;203:69-71 pubmed
    ..The reduction was marginal at the age of 2-3 weeks, and became progressively prominent to adulthood, with the potentiation being 26% of that of the wild-type mice at 9-10 weeks. ..
  63. Toyoda H, Zhao M, Zhuo M. Roles of NMDA receptor NR2A and NR2B subtypes for long-term depression in the anterior cingulate cortex. Eur J Neurosci. 2005;22:485-94 pubmed
    ..In the hippocampus, the NR2A subunit is believed to be involved in the induction of LTP, whereas the NR2B subunit contributes to the formation ..
  64. Watanabe M, Mishina M, Inoue Y. Distinct spatiotemporal distributions of the N-methyl-D-aspartate receptor channel subunit mRNAs in the mouse cervical cord. J Comp Neurol. 1994;345:314-9 pubmed
    ..Moreover, this spatial heterogeneity might be generated through drastic alterations in the subunit composition of the channel complex during spinal cord development. ..
  65. Foldes R, Adams S, Fantaske R, Kamboj R. Human N-methyl-D-aspartate receptor modulatory subunit hNR2A: cloning and sequencing of the cDNA and primary structure of the protein. Biochim Biophys Acta. 1994;1223:155-9 pubmed
    ..The hNR2A cDNA demonstrated an 88-89% nucleotide (nt) identity with the corresponding rodent cDNAs. The nt sequence of hNR2A would encode a 1464-aa protein that has a 95.2% identity with the rodent NR2A subunits.
  66. Boyce Rustay J, Holmes A. Ethanol-related behaviors in mice lacking the NMDA receptor NR2A subunit. Psychopharmacology (Berl). 2006;187:455-66 pubmed
    The ionotropic NMDA glutamate receptor is composed of NR1 and NR2 (NR2A-D) subunits...
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    ..These data suggest that basal, but not evoked, NMDAR activity regulates gene expression in part through HDAC4, and, that HDAC4 has neuroprotective functions under conditions of low NMDAR activity. ..
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    ..Then we testified that selective motor cortex injury was related to disparate distribution of NR2A and NR2B by measuring their protein expression with the method of Western blot...
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    ..a developmental decrease in the probability of transmitter release (P(r)) and an increase in the contribution of GluN2A (NR2A) subunits to the NMDA receptor-mediated excitatory postsynaptic current (EPSC)...
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    ..This study defines a specific role for cadherins and catenins in synapse organization beyond their roles in mediating cell adhesion. ..
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    ..In contrast, no effects on stress-related phenotypes were detected. Levels of NR2A-NR2D subunits of the NMDA receptor in specific brain regions were compared between NR1+/- mice and wild-type ..
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    ..In this paper we show that C-terminal truncation of NR2A and NR2C subunits in mice (NR2A/C(DeltaC/DeltaC)) impairs synaptic transmission and plasticity at the cerebellar ..
  74. Fujiyama T, Yamada M, Terao M, Terashima T, Hioki H, Inoue Y, et al. Inhibitory and excitatory subtypes of cochlear nucleus neurons are defined by distinct bHLH transcription factors, Ptf1a and Atoh1. Development. 2009;136:2049-58 pubmed publisher
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    In cerebral cortex there is a developmental switch from NR2B- to NR2A-containing NMDA receptors (NMDARs) driven by activity and sensory experience...
  76. Hagino Y, Kasai S, Han W, Yamamoto H, Nabeshima T, Mishina M, et al. Essential role of NMDA receptor channel ?4 subunit (GluN2D) in the effects of phencyclidine, but not methamphetamine. PLoS ONE. 2010;5:e13722 pubmed publisher
    ..cortex (PFC) using in vivo microdialysis in mice lacking the NMDA receptor channel ?1 or ?4 subunit (GluR?1 [GluN2A] or GluR?4 [GluN2D]) and locomotor activity...
  77. Ito I, Futai K, Katagiri H, Watanabe M, Sakimura K, Mishina M, et al. Synapse-selective impairment of NMDA receptor functions in mice lacking NMDA receptor epsilon 1 or epsilon 2 subunit. J Physiol. 1997;500 ( Pt 2):401-8 pubmed
    ..5. These results suggest that NMDA receptors with different subunit compositions function within a single CA3 pyramidal cell in a synapse-selective manner. ..
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    ..A majority of studies show that both NR2A and NR2B-containing NMDARs can contribute to LTP, but their unique contributions to this form of synaptic ..
  79. Altafaj X, Ortiz Abalia J, Fernandez M, Potier M, Laffaire J, Andreu N, et al. Increased NR2A expression and prolonged decay of NMDA-induced calcium transient in cerebellum of TgDyrk1A mice, a mouse model of Down syndrome. Neurobiol Dis. 2008;32:377-84 pubmed publisher
    ..Transcriptome analysis showed an upregulation of the NR2A subunit of the NMDA type of glutamate receptors in TgDyrk1A cerebellum...
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    ..A subset of these antibodies, present in 40% of patients, cross-reacts with the NR2A and NR2B subunits of the N-methyl-d-aspartate receptor (NMDAR)...
  81. Spalloni A, Origlia N, Sgobio C, Trabalza A, Nutini M, Berretta N, et al. Postsynaptic alteration of NR2A subunit and defective autophosphorylation of alphaCaMKII at threonine-286 contribute to abnormal plasticity and morphology of upper motor neurons in presymptomatic SOD1G93A mice, a murine model for amyotrophic lateral . Cereb Cortex. 2011;21:796-805 pubmed publisher
    ..We show that presymptomatic SOD1(G93A) exhibit a selective decrease of NR2A subunit expression and of the alphaCa²(+)/calmodulin-dependent kinase autophosphorylation at threonine-286 in the ..
  82. Tang T, Yang F, Chen B, Lu Y, Ji Y, Roche K, et al. Dysbindin regulates hippocampal LTP by controlling NMDA receptor surface expression. Proc Natl Acad Sci U S A. 2009;106:21395-400 pubmed publisher
    ..Imaging analyses revealed a marked increase in surface NR2A, but not NR2B, in hippocampal neurons derived from dysbindin-null mutant mice (Dys-/-)...
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    ..Ambient extracellular zinc levels are too low for tonic occupation of the GluN2A-specific nanomolar zinc sites on NMDA receptors (NMDARs)...
  84. Zhao J, Constantine Paton M. NR2A-/- mice lack long-term potentiation but retain NMDA receptor and L-type Ca2+ channel-dependent long-term depression in the juvenile superior colliculus. J Neurosci. 2007;27:13649-54 pubmed
    ..In the visual layers of NR2A-/- juvenile superior colliculus (SC), synapses lose miniature NMDAR currents, leaving NR2B-rich receptors in ..
  85. Fernandez E, Collins M, Uren R, Kopanitsa M, Komiyama N, Croning M, et al. Targeted tandem affinity purification of PSD-95 recovers core postsynaptic complexes and schizophrenia susceptibility proteins. Mol Syst Biol. 2009;5:269 pubmed publisher
    ..This targeted TAP tagging strategy is generally applicable to mammalian proteomics and systems biology approaches to disease. ..