Grin1

Summary

Gene Symbol: Grin1
Description: glutamate receptor, ionotropic, NMDA1 (zeta 1)
Alias: GluN1, GluRdelta1, GluRzeta1, M100174, NMD-R1, NMDAR1, NR1, Nmdar, Rgsc174, glutamate receptor ionotropic, NMDA 1, N-methyl-D-aspartate receptor subunit NR1, glutamate [NMDA] receptor subunit zeta-1
Species: mouse
Products:     Grin1

Top Publications

  1. Köhr G, Jensen V, Koester H, Mihaljevic A, Utvik J, Kvello A, et al. Intracellular domains of NMDA receptor subtypes are determinants for long-term potentiation induction. J Neurosci. 2003;23:10791-9 pubmed
    ..At hippocampal CA3-to-CA1 synapses of adult mice, different NMDAR subtypes with distinct functionality assemble from NR1 with NR2A and/or NR2B subunits...
  2. Ohtsuka N, Tansky M, Kuang H, Kourrich S, Thomas M, Rubenstein J, et al. Functional disturbances in the striatum by region-specific ablation of NMDA receptors. Proc Natl Acad Sci U S A. 2008;105:12961-6 pubmed publisher
    ..These results demonstrate that the NMDA receptor plays an essential role in the integration of dopamine signaling in the striatum and that is required in behavioral function. ..
  3. Tsien J, Huerta P, Tonegawa S. The essential role of hippocampal CA1 NMDA receptor-dependent synaptic plasticity in spatial memory. Cell. 1996;87:1327-38 pubmed
    We have produced a mouse strain in which the deletion of the NMDAR1 gene is restricted to the CA1 pyramidal cells of the hippocampus by using a new and general method that allows CA1-restricted gene knockout...
  4. Matsugami T, Tanemura K, Mieda M, Nakatomi R, Yamada K, Kondo T, et al. From the Cover: Indispensability of the glutamate transporters GLAST and GLT1 to brain development. Proc Natl Acad Sci U S A. 2006;103:12161-6 pubmed
  5. Tashiro A, Sandler V, Toni N, Zhao C, Gage F. NMDA-receptor-mediated, cell-specific integration of new neurons in adult dentate gyrus. Nature. 2006;442:929-33 pubmed
    ..This information-specific addition of new circuits through selective survival or death of new neurons may be a unique attribute of new neurons that enables them to play a critical role in learning and memory. ..
  6. Nakazawa K, Quirk M, Chitwood R, Watanabe M, Yeckel M, Sun L, et al. Requirement for hippocampal CA3 NMDA receptors in associative memory recall. Science. 2002;297:211-8 pubmed
    ..These results provide direct evidence for CA3 NMDA receptor involvement in associative memory recall. ..
  7. Cui Z, Wang H, Tan Y, Zaia K, Zhang S, Tsien J. Inducible and reversible NR1 knockout reveals crucial role of the NMDA receptor in preserving remote memories in the brain. Neuron. 2004;41:781-93 pubmed
    ..Thus, our study reveals a hitherto unrecognized role of the NMDA receptor in dynamically maintaining the long-term synaptic stability of memory storage circuits in the brain. ..
  8. Mohn A, Gainetdinov R, Caron M, Koller B. Mice with reduced NMDA receptor expression display behaviors related to schizophrenia. Cell. 1999;98:427-36 pubmed
    ..We report here the generation of mice expressing only 5% of normal levels of the essential NMDAR1 (NR1) subunit...
  9. Watanabe M, Inoue Y, Sakimura K, Mishina M. Developmental changes in distribution of NMDA receptor channel subunit mRNAs. Neuroreport. 1992;3:1138-40 pubmed
    ..In contrast, the zeta 1 subunit mRNA distributes ubiquitously in the brain throughout development. These findings suggest that changes in the subunit composition of the NMDA receptor channel take place during brain development. ..
  10. Chen L, Gilman A, Kozasa T. A candidate target for G protein action in brain. J Biol Chem. 1999;274:26931-8 pubmed
    An effector candidate for G protein action, GRIN1, was identified by screening a cDNA expression library with phosphorylated GTPgammaS-G(z)alpha as a probe. GRIN1 is a novel protein without substantial homology to known protein domains...

Detail Information

Publications72

  1. Köhr G, Jensen V, Koester H, Mihaljevic A, Utvik J, Kvello A, et al. Intracellular domains of NMDA receptor subtypes are determinants for long-term potentiation induction. J Neurosci. 2003;23:10791-9 pubmed
    ..At hippocampal CA3-to-CA1 synapses of adult mice, different NMDAR subtypes with distinct functionality assemble from NR1 with NR2A and/or NR2B subunits...
  2. Ohtsuka N, Tansky M, Kuang H, Kourrich S, Thomas M, Rubenstein J, et al. Functional disturbances in the striatum by region-specific ablation of NMDA receptors. Proc Natl Acad Sci U S A. 2008;105:12961-6 pubmed publisher
    ..These results demonstrate that the NMDA receptor plays an essential role in the integration of dopamine signaling in the striatum and that is required in behavioral function. ..
  3. Tsien J, Huerta P, Tonegawa S. The essential role of hippocampal CA1 NMDA receptor-dependent synaptic plasticity in spatial memory. Cell. 1996;87:1327-38 pubmed
    We have produced a mouse strain in which the deletion of the NMDAR1 gene is restricted to the CA1 pyramidal cells of the hippocampus by using a new and general method that allows CA1-restricted gene knockout...
  4. Matsugami T, Tanemura K, Mieda M, Nakatomi R, Yamada K, Kondo T, et al. From the Cover: Indispensability of the glutamate transporters GLAST and GLT1 to brain development. Proc Natl Acad Sci U S A. 2006;103:12161-6 pubmed
  5. Tashiro A, Sandler V, Toni N, Zhao C, Gage F. NMDA-receptor-mediated, cell-specific integration of new neurons in adult dentate gyrus. Nature. 2006;442:929-33 pubmed
    ..This information-specific addition of new circuits through selective survival or death of new neurons may be a unique attribute of new neurons that enables them to play a critical role in learning and memory. ..
  6. Nakazawa K, Quirk M, Chitwood R, Watanabe M, Yeckel M, Sun L, et al. Requirement for hippocampal CA3 NMDA receptors in associative memory recall. Science. 2002;297:211-8 pubmed
    ..These results provide direct evidence for CA3 NMDA receptor involvement in associative memory recall. ..
  7. Cui Z, Wang H, Tan Y, Zaia K, Zhang S, Tsien J. Inducible and reversible NR1 knockout reveals crucial role of the NMDA receptor in preserving remote memories in the brain. Neuron. 2004;41:781-93 pubmed
    ..Thus, our study reveals a hitherto unrecognized role of the NMDA receptor in dynamically maintaining the long-term synaptic stability of memory storage circuits in the brain. ..
  8. Mohn A, Gainetdinov R, Caron M, Koller B. Mice with reduced NMDA receptor expression display behaviors related to schizophrenia. Cell. 1999;98:427-36 pubmed
    ..We report here the generation of mice expressing only 5% of normal levels of the essential NMDAR1 (NR1) subunit...
  9. Watanabe M, Inoue Y, Sakimura K, Mishina M. Developmental changes in distribution of NMDA receptor channel subunit mRNAs. Neuroreport. 1992;3:1138-40 pubmed
    ..In contrast, the zeta 1 subunit mRNA distributes ubiquitously in the brain throughout development. These findings suggest that changes in the subunit composition of the NMDA receptor channel take place during brain development. ..
  10. Chen L, Gilman A, Kozasa T. A candidate target for G protein action in brain. J Biol Chem. 1999;274:26931-8 pubmed
    An effector candidate for G protein action, GRIN1, was identified by screening a cDNA expression library with phosphorylated GTPgammaS-G(z)alpha as a probe. GRIN1 is a novel protein without substantial homology to known protein domains...
  11. Rudhard Y, Kneussel M, Nassar M, Rast G, Annala A, Chen P, et al. Absence of Whisker-related pattern formation in mice with NMDA receptors lacking coincidence detection properties and calcium signaling. J Neurosci. 2003;23:2323-32 pubmed
    ..Furthermore, the NR1 N598R mutation does not affect expression levels of NMDAR subunits and other important neurotransmitter receptors...
  12. McHugh T, Jones M, Quinn J, Balthasar N, Coppari R, Elmquist J, et al. Dentate gyrus NMDA receptors mediate rapid pattern separation in the hippocampal network. Science. 2007;317:94-9 pubmed
    ..a mouse strain that lacks the gene encoding the essential subunit of the N-methyl-d-aspartate (NMDA) receptor NR1, specifically in dentate gyrus granule cells...
  13. Lee L, Lo F, Erzurumlu R. NMDA receptor-dependent regulation of axonal and dendritic branching. J Neurosci. 2005;25:2304-11 pubmed
    ..Genetic impairment of NMDA receptor (NMDAR) function blocks development of barrelettes in the PrV. Underlying cellular and functional defects are not known...
  14. Fukaya M, Kato A, Lovett C, Tonegawa S, Watanabe M. Retention of NMDA receptor NR2 subunits in the lumen of endoplasmic reticulum in targeted NR1 knockout mice. Proc Natl Acad Sci U S A. 2003;100:4855-60 pubmed
    ..mammalian central nervous system, and the N-methyl-D-aspartate-selective glutamate receptor (NR) consisting of the NR1 subunit and an NR2 or NR3 subunit plays crucial roles in synaptic transmission, plasticity, and learning and memory...
  15. Moy S, Perez A, Koller B, Duncan G. Amphetamine-induced disruption of prepulse inhibition in mice with reduced NMDA receptor function. Brain Res. 2006;1089:186-94 pubmed
    Genetically altered mice with reductions in the NR1 subunit of the N-methyl-d-aspartate (NMDA) receptor have been proposed as a model for the intrinsic NMDA hypofunction hypothesized for schizophrenia...
  16. Niewoehner B, Single F, Hvalby Ø, Jensen V, Meyer zum Alten Borgloh S, Seeburg P, et al. Impaired spatial working memory but spared spatial reference memory following functional loss of NMDA receptors in the dentate gyrus. Eur J Neurosci. 2007;25:837-46 pubmed
    ..Here we generated genetically modified mice (NR1(deltaDG) mice) exhibiting complete loss of the NR1 subunit of the N-methyl-D-aspartate receptor specifically in the ..
  17. Huerta P, Sun L, Wilson M, Tonegawa S. Formation of temporal memory requires NMDA receptors within CA1 pyramidal neurons. Neuron. 2000;25:473-80 pubmed
    ..Work on the rodent hippocampus has shown that NMDA receptor (NMDAR) -mediated plasticity is essential for spatial memory...
  18. Korotkova T, Fuchs E, Ponomarenko A, von Engelhardt J, Monyer H. NMDA receptor ablation on parvalbumin-positive interneurons impairs hippocampal synchrony, spatial representations, and working memory. Neuron. 2010;68:557-69 pubmed publisher
    ..and behavioral deficits in mice with selective ablation of NMDA receptors in parvalbumin-positive interneurons (NR1(PVCre-/-))...
  19. Li B, Devidze N, Barengolts D, Prostak N, Sphicas E, Apicella A, et al. NMDA receptor phosphorylation at a site affected in schizophrenia controls synaptic and behavioral plasticity. J Neurosci. 2009;29:11965-72 pubmed publisher
    ..This knock-in mutation causes severe impairment in NMDAR synaptic incorporation and NMDAR-mediated synaptic transmission...
  20. Belforte J, Zsiros V, Sklar E, Jiang Z, Yu G, Li Y, et al. Postnatal NMDA receptor ablation in corticolimbic interneurons confers schizophrenia-like phenotypes. Nat Neurosci. 2010;13:76-83 pubmed publisher
    ..Here, we characterized a mouse strain in which the essential NR1 subunit of the NMDA receptor (NMDAR) was selectively eliminated in 40-50% of cortical and hippocampal interneurons in early postnatal development...
  21. Engblom D, Bilbao A, Sanchis Segura C, Dahan L, Perreau Lenz S, Balland B, et al. Glutamate receptors on dopamine neurons control the persistence of cocaine seeking. Neuron. 2008;59:497-508 pubmed publisher
    ..Here, we generated mice lacking the GluR1, GluR2, or NR1 receptor subunits selectively in dopamine neurons...
  22. Forrest D, Yuzaki M, Soares H, Ng L, Luk D, Sheng M, et al. Targeted disruption of NMDA receptor 1 gene abolishes NMDA response and results in neonatal death. Neuron. 1994;13:325-38 pubmed
    In vitro studies have suggested that the NMDA receptor consists of an essential subunit, NR1, and various modulatory NR2 subunits. To test this hypothesis directly in vivo, we generated mice carrying a disrupted NR1 allele...
  23. Gray J, Shi Y, Usui H, During M, Sakimura K, Nicoll R. Distinct modes of AMPA receptor suppression at developing synapses by GluN2A and GluN2B: single-cell NMDA receptor subunit deletion in vivo. Neuron. 2011;71:1085-101 pubmed publisher
    ..Similar to GluN1, GluN2B deletion increases the number of functional synapses, while GluN2A deletion increases the strength of ..
  24. Rampon C, Tang Y, Goodhouse J, Shimizu E, Kyin M, Tsien J. Enrichment induces structural changes and recovery from nonspatial memory deficits in CA1 NMDAR1-knockout mice. Nat Neurosci. 2000;3:238-44 pubmed
    ..Therefore, our data indicate that CA1 NMDA receptor activity is critical in hippocampus-dependent nonspatial memory, but is not essential for experience-induced synaptic structural changes. ..
  25. Jin X, Costa R. Start/stop signals emerge in nigrostriatal circuits during sequence learning. Nature. 2010;466:457-62 pubmed publisher
    ..These results have important implications for understanding the functional organization of actions and the sequence initiation and termination impairments observed in basal ganglia disorders. ..
  26. Cui Z, Lindl K, Mei B, Zhang S, Tsien J. Requirement of NMDA receptor reactivation for consolidation and storage of nondeclarative taste memory revealed by inducible NR1 knockout. Eur J Neurosci. 2005;22:755-63 pubmed
    ..and region-specific gene knockout technique to investigate the requirements for cortical NMDA receptors (NMDAR) during the various stages (acquisition, consolidation and storage, and retrieval) of nondeclarative, hippocampal-..
  27. Ultanir S, Kim J, Hall B, Deerinck T, Ellisman M, Ghosh A. Regulation of spine morphology and spine density by NMDA receptor signaling in vivo. Proc Natl Acad Sci U S A. 2007;104:19553-8 pubmed
    ..Genetic deletion of the NR1 subunit of the NMDA receptor in the cortex leads to a decrease in spine density and an increase in spine head size ..
  28. Iwasato T, Datwani A, Wolf A, Nishiyama H, Taguchi Y, Tonegawa S, et al. Cortex-restricted disruption of NMDAR1 impairs neuronal patterns in the barrel cortex. Nature. 2000;406:726-31 pubmed
    ..We have generated mice in which deletion of the NMDAR1 (NR1) gene is restricted to excitatory cortical neurons, and here we show that sensory periphery-related patterns ..
  29. Barkus C, Dawson L, Sharp T, Bannerman D. GluN1 hypomorph mice exhibit wide-ranging behavioral alterations. Genes Brain Behav. 2012;11:342-51 pubmed publisher
    ..b>GluN1 'hypomorph' (GluN1(hypo) ) mice exhibit reduced NMDA receptor expression and have been suggested as a mouse model ..
  30. Guo F, Maeda Y, Ko E, Delgado M, Horiuchi M, Soulika A, et al. Disruption of NMDA receptors in oligodendroglial lineage cells does not alter their susceptibility to experimental autoimmune encephalomyelitis or their normal development. J Neurosci. 2012;32:639-45 pubmed publisher
    ..autoimmune encephalomyelitis (EAE), a model of human MS, by timed conditional disruption of oligodendroglial NR1, an essential subunit of functional NMDARs, using an inducible proteolipid protein (Plp) promoter-driven Cre-loxP ..
  31. Li Y, Erzurumlu R, Chen C, Jhaveri S, Tonegawa S. Whisker-related neuronal patterns fail to develop in the trigeminal brainstem nuclei of NMDAR1 knockout mice. Cell. 1994;76:427-37 pubmed
    ..We applied the gene targeting to the NMDAR1 gene and created a mutant mouse that lacks functional NMDA receptors...
  32. Tokita Y, Bessho Y, Masu M, Nakamura K, Nakao K, Katsuki M, et al. Characterization of excitatory amino acid neurotoxicity in N-methyl-D-aspartate receptor-deficient mouse cortical neuronal cells. Eur J Neurosci. 1996;8:69-78 pubmed
    ..Mutant mice lacking a functional NMDA receptor were generated by gene targeting of the NR1 NMDA receptor subunit...
  33. Hisatsune C, Umemori H, Inoue T, Michikawa T, Kohda K, Mikoshiba K, et al. Phosphorylation-dependent regulation of N-methyl-D-aspartate receptors by calmodulin. J Biol Chem. 1997;272:20805-10 pubmed
    ..By using the yeast two-hybrid system, we found that calmodulin interacts with the COOH terminus of the NR1 subunit and inactivates the channels in a Ca2+-dependent manner...
  34. Wang L, Li F, Wang D, Xie K, Wang D, Shen X, et al. NMDA receptors in dopaminergic neurons are crucial for habit learning. Neuron. 2011;72:1055-66 pubmed publisher
    ..Here, we show that mice with dopaminergic neuron-specific NMDAR1 deletion are impaired in a variety of habit-learning tasks, while normal in some other dopamine-modulated ..
  35. Nakazawa K, Sun L, Quirk M, Rondi Reig L, Wilson M, Tonegawa S. Hippocampal CA3 NMDA receptors are crucial for memory acquisition of one-time experience. Neuron. 2003;38:305-15 pubmed
    ..These results suggest that CA3 NRs play a crucial role in rapid hippocampal encoding of novel information for fast learning of one-time experience. ..
  36. Halene T, Ehrlichman R, Liang Y, Christian E, Jonak G, Gur T, et al. Assessment of NMDA receptor NR1 subunit hypofunction in mice as a model for schizophrenia. Genes Brain Behav. 2009;8:661-75 pubmed publisher
    ..Clinical and experimental evidence suggests a dysregulation of NMDAR function and glutamatergic pathways in the pathophysiology of schizophrenia...
  37. Cravens C, Vargas Pinto N, Christian K, Nakazawa K. CA3 NMDA receptors are crucial for rapid and automatic representation of context memory. Eur J Neurosci. 2006;24:1771-80 pubmed
    ..It appears that rapid and automatic context memory representations from one-time experience are mediated, at least in part, by CA3 NMDA receptors. ..
  38. Iwasato T, Erzurumlu R, Huerta P, Chen D, Sasaoka T, Ulupinar E, et al. NMDA receptor-dependent refinement of somatotopic maps. Neuron. 1997;19:1201-10 pubmed
    ..We demonstrate that ectopic expression of a transgene of an NMDAR1 splice variant rescues neonatally fatal NMDAR1 knockout (KO) mice, although the average life span varies depending ..
  39. Tezuka T, Umemori H, Akiyama T, Nakanishi S, Yamamoto T. PSD-95 promotes Fyn-mediated tyrosine phosphorylation of the N-methyl-D-aspartate receptor subunit NR2A. Proc Natl Acad Sci U S A. 1999;96:435-40 pubmed
    ..These results suggest that PSD-95 is critical for regulation of NMDA receptor activity by Fyn and other Src-family PTKs, serving as a molecular scaffold for anchoring these PTKs to NR2A. ..
  40. Beutler L, WANAT M, Quintana A, Sanz E, Bamford N, Zweifel L, et al. Balanced NMDA receptor activity in dopamine D1 receptor (D1R)- and D2R-expressing medium spiny neurons is required for amphetamine sensitization. Proc Natl Acad Sci U S A. 2011;108:4206-11 pubmed publisher
    ..However, the cell type and brain region in which NMDAR signaling is required for AMPH sensitization remain unresolved...
  41. Sprengel R, Suchanek B, Amico C, Brusa R, Burnashev N, Rozov A, et al. Importance of the intracellular domain of NR2 subunits for NMDA receptor function in vivo. Cell. 1998;92:279-89 pubmed
    ..C-terminal truncation of NR2 subunits does not interfere with the formation of gateable receptor channels that can be synaptically activated. Thus, the phenotypes of our mutants appear to reflect defective intracellular signaling. ..
  42. Kew J, Koester A, Moreau J, Jenck F, Ouagazzal A, Mutel V, et al. Functional consequences of reduction in NMDA receptor glycine affinity in mice carrying targeted point mutations in the glycine binding site. J Neurosci. 2000;20:4037-49 pubmed
    ..homologous recombination to generate two mouse lines carrying point mutations in the glycine binding site of the NMDAR1 subunit (Grin1)...
  43. Ballard T, Pauly Evers M, Higgins G, Ouagazzal A, Mutel V, Borroni E, et al. Severe impairment of NMDA receptor function in mice carrying targeted point mutations in the glycine binding site results in drug-resistant nonhabituating hyperactivity. J Neurosci. 2002;22:6713-23 pubmed
    ..We previously have described two mouse lines carrying point mutations in the NMDA receptor glycine binding site, Grin1(D481N) and Grin1(K483Q), which exhibit 5- and 86-fold reductions in receptor glycine affinity, respectively...
  44. Jinde S, Belforte J, Yamamoto J, Wilson M, Tonegawa S, Nakazawa K. Lack of kainic acid-induced gamma oscillations predicts subsequent CA1 excitotoxic cell death. Eur J Neurosci. 2009;30:1036-55 pubmed publisher
  45. Moy S, Nadler J, Poe M, Nonneman R, Young N, Koller B, et al. Development of a mouse test for repetitive, restricted behaviors: relevance to autism. Behav Brain Res. 2008;188:178-94 pubmed
    ..Four inbred mouse strains, C57BL/6J, BALB/cByJ, BTBR T+tf/J, and FVB/NJ, and mice with reduced expression of Grin1, leading to NMDA receptor hypofunction (NR1neo/neo mice), were tested for exploration and preference for olfactory ..
  46. Bordji K, Becerril Ortega J, Nicole O, Buisson A. Activation of extrasynaptic, but not synaptic, NMDA receptors modifies amyloid precursor protein expression pattern and increases amyloid-ß production. J Neurosci. 2010;30:15927-42 pubmed publisher
    ..and neuronal A? release was established, and recent reports suggest that synaptic and extrasynaptic NMDA receptor (NMDAR) activation may have distinct consequences in plasticity, gene regulation, and neuronal death...
  47. Duncan G, Moy S, Perez A, Eddy D, Zinzow W, Lieberman J, et al. Deficits in sensorimotor gating and tests of social behavior in a genetic model of reduced NMDA receptor function. Behav Brain Res. 2004;153:507-19 pubmed
    ..NMDA receptor hypofunction, a mouse line was developed that expresses low levels of the NMDA R1 subunit (NR1) of the NMDA receptor...
  48. Ng D, Pitcher G, Szilard R, Sertié A, Kanisek M, Clapcote S, et al. Neto1 is a novel CUB-domain NMDA receptor-interacting protein required for synaptic plasticity and learning. PLoS Biol. 2009;7:e41 pubmed publisher
    The N-methyl-D-aspartate receptor (NMDAR), a major excitatory ligand-gated ion channel in the central nervous system (CNS), is a principal mediator of synaptic plasticity...
  49. Rodríguez Muñoz M, de la Torre Madrid E, Sánchez Blázquez P, Wang J, Garzón J. NMDAR-nNOS generated zinc recruits PKCgamma to the HINT1-RGS17 complex bound to the C terminus of Mu-opioid receptors. Cell Signal. 2008;20:1855-64 pubmed publisher
    ..The N-methyl-D-aspartate receptor (NMDAR) antagonist, MK801, also prevented PKCgamma recruitment to MORs and serine phosphorylation of the receptors ..
  50. Zhang Z, Peterson M, Liu H. Essential role of postsynaptic NMDA receptors in developmental refinement of excitatory synapses. Proc Natl Acad Sci U S A. 2013;110:1095-100 pubmed publisher
    ..Our data support a model in which activation of NMDARs in postsynaptic neurons initiates synaptic refinement. ..
  51. Parker J, Beutler L, Palmiter R. The contribution of NMDA receptor signaling in the corticobasal ganglia reward network to appetitive Pavlovian learning. J Neurosci. 2011;31:11362-9 pubmed publisher
    ..To better understand where NMDAR signaling is necessary for learning, we combined viral genetic strategies with genetic mouse models to investigate ..
  52. Collins M, Husi H, Yu L, Brandon J, Anderson C, Blackstock W, et al. Molecular characterization and comparison of the components and multiprotein complexes in the postsynaptic proteome. J Neurochem. 2006;97 Suppl 1:16-23 pubmed
    ..nine in AMPA-receptor immuno-purifications, 100 in isolates using an antibody against the NMDA receptor subunit NR1, and 170 by peptide-affinity purification of complexes with the C-terminus of NR2B...
  53. Bickel S, Lipp H, Umbricht D. Early auditory sensory processing deficits in mouse mutants with reduced NMDA receptor function. Neuropsychopharmacology. 2008;33:1680-9 pubmed
    ..We tested the paradigms mentioned in mouse mutants with reduced expression of the NR1 subunit of the NMDA receptor (N = 15) and their wild-type littermates (N = 16)...
  54. Rondi Reig L, Petit G, Tobin C, Tonegawa S, Mariani J, Berthoz A. Impaired sequential egocentric and allocentric memories in forebrain-specific-NMDA receptor knock-out mice during a new task dissociating strategies of navigation. J Neurosci. 2006;26:4071-81 pubmed
    ..lacking hippocampal CA1 NMDA receptors and presenting a reduction of these receptors in the deep cortical layers (NR1-KO mice)...
  55. Vanhoose A, Winder D. NMDA and beta1-adrenergic receptors differentially signal phosphorylation of glutamate receptor type 1 in area CA1 of hippocampus. J Neurosci. 2003;23:5827-34 pubmed
    ..open channel probability and is permissive for both the synaptic expression of the receptor and NMDA-receptor (NMDAR)-dependent long-term potentiation (LTP)...
  56. Datwani A, Iwasato T, Itohara S, Erzurumlu R. NMDA receptor-dependent pattern transfer from afferents to postsynaptic cells and dendritic differentiation in the barrel cortex. Mol Cell Neurosci. 2002;21:477-92 pubmed
    ..In CxNR1KO mice, cortical excitatory neurons lack NR1, the essential subunit of the NMDAR, and in their primary somatosensory (S1) cortex whisker-specific cellular patterns, "barrels," are ..
  57. Dang M, Yokoi F, Yin H, Lovinger D, Wang Y, Li Y. Disrupted motor learning and long-term synaptic plasticity in mice lacking NMDAR1 in the striatum. Proc Natl Acad Sci U S A. 2006;103:15254-9 pubmed
    ..To examine the role of striatal NMDAR in motor learning, we created striatum-specific NMDAR1 subunit knockout mice, analyzed the striatal anatomy and neuronal morphology of these mice, evaluated their ..
  58. Furuse T, Wada Y, Hattori K, Yamada I, Kushida T, Shibukawa Y, et al. Phenotypic characterization of a new Grin1 mutant mouse generated by ENU mutagenesis. Eur J Neurosci. 2010;31:1281-91 pubmed publisher
    ..males treated with ENU and untreated DBA/2J females in the open-field test and isolated behavioral mutant M100174, which exhibited a significant increase in spontaneous locomotor activity...
  59. Shimshek D, Bus T, Grinevich V, Single F, Mack V, Sprengel R, et al. Impaired reproductive behavior by lack of GluR-B containing AMPA receptors but not of NMDA receptors in hypothalamic and septal neurons. Mol Endocrinol. 2006;20:219-31 pubmed
  60. De Biase L, Kang S, Baxi E, Fukaya M, Pucak M, Mishina M, et al. NMDA receptor signaling in oligodendrocyte progenitors is not required for oligodendrogenesis and myelination. J Neurosci. 2011;31:12650-62 pubmed publisher
    ..Although glutamate influences the proliferation and maturation of these progenitors in vitro, the role of NMDAR signaling in oligodendrogenesis and myelination in vivo is not known...
  61. Bradley J, Carter S, Rao V, Wang J, Finkbeiner S. Splice variants of the NR1 subunit differentially induce NMDA receptor-dependent gene expression. J Neurosci. 2006;26:1065-76 pubmed
    Subunits of the NMDA receptor (NMDAR) associate with many postsynaptic proteins that substantially broaden its signaling capacity...
  62. Labrie V, Wang W, Barger S, Baker G, Roder J. Genetic loss of D-amino acid oxidase activity reverses schizophrenia-like phenotypes in mice. Genes Brain Behav. 2010;9:11-25 pubmed publisher
    Reduced function of the N-methyl-d-aspartate receptor (NMDAR) has been implicated in the pathophysiology of schizophrenia...
  63. Bannerman D, Bus T, Taylor A, Sanderson D, Schwarz I, Jensen V, et al. Dissecting spatial knowledge from spatial choice by hippocampal NMDA receptor deletion. Nat Neurosci. 2012;15:1153-9 pubmed publisher
    Hippocampal NMDA receptors (NMDARs) and NMDAR-dependent synaptic plasticity are widely considered crucial substrates of long-term spatial memory, although their precise role remains uncertain...
  64. McHugh T, Blum K, Tsien J, Tonegawa S, Wilson M. Impaired hippocampal representation of space in CA1-specific NMDAR1 knockout mice. Cell. 1996;87:1339-49 pubmed
    ..multiple electrode recording techniques to freely behaving mice with a CA1 pyramidal cell-specific knockout of the NMDAR1 gene...
  65. McBain C, Mayer M. N-methyl-D-aspartic acid receptor structure and function. Physiol Rev. 1994;74:723-60 pubmed
  66. Watanabe M, Mishina M, Inoue Y. Distinct spatiotemporal expressions of five NMDA receptor channel subunit mRNAs in the cerebellum. J Comp Neurol. 1994;343:513-9 pubmed
    ..These findings suggest that anatomical organization of the epsilon subunits is heterogeneous in the cerebellum both spatially and temporally, which would give rise to functional diversity of the NMDA receptor channel. ..
  67. Carlen M, Meletis K, Siegle J, Cardin J, Futai K, Vierling Claassen D, et al. A critical role for NMDA receptors in parvalbumin interneurons for gamma rhythm induction and behavior. Mol Psychiatry. 2012;17:537-48 pubmed publisher
    ..The disruption of NMDA receptor (NMDAR) signaling specifically in FS PV interneurons is therefore hypothesized to give rise to neural network dysfunction ..
  68. Yamazaki M, Mori H, Araki K, Mori K, Mishina M. Cloning, expression and modulation of a mouse NMDA receptor subunit. FEBS Lett. 1992;300:39-45 pubmed
    ..It has been found that the zeta 1 channel activity is positively modulated by treatment with 12-O-tetradecanoylphorbol 13-acetate (TPA). ..
  69. Single F, Rozov A, Burnashev N, Zimmermann F, Hanley D, Forrest D, et al. Dysfunctions in mice by NMDA receptor point mutations NR1(N598Q) and NR1(N598R). J Neurosci. 2000;20:2558-66 pubmed
    NMDA receptors in mice were mutated by gene targeting to substitute asparagine (N) in position 598 of the NR1 subunit to glutamine (Q) or arginine (R)...
  70. Zweifel L, Argilli E, Bonci A, Palmiter R. Role of NMDA receptors in dopamine neurons for plasticity and addictive behaviors. Neuron. 2008;59:486-96 pubmed publisher
    A single exposure to drugs of abuse produces an NMDA receptor (NMDAR)-dependent long-term potentiation (LTP) of AMPA receptor (AMPAR) currents in DA neurons; however, the importance of LTP for various aspects of drug addiction is unclear...