Gene Symbol: Grik5
Description: glutamate receptor, ionotropic, kainate 5 (gamma 2)
Alias: GluK5, GluRgamma2, KA2, glutamate receptor ionotropic, kainate 5, gluR gamma-2, glutamate receptor KA-2, glutamate receptor gamma-2
Species: mouse
Products:     Grik5

Top Publications

  1. Marques J, Rodrigues R, Valbuena S, Rozas J, Selak S, Marin P, et al. CRMP2 tethers kainate receptor activity to cytoskeleton dynamics during neuronal maturation. J Neurosci. 2013;33:18298-310 pubmed publisher
    ..In the present study, we demonstrate the interaction of the CRMP2 and CRMP4 proteins with the GluK5 subunit of the kainate (KA) receptor (KAR) and investigated the role of KARs in modulating the development of ..
  2. Nasu Nishimura Y, Hurtado D, Braud S, Tang T, Isaac J, Roche K. Identification of an endoplasmic reticulum-retention motif in an intracellular loop of the kainate receptor subunit KA2. J Neurosci. 2006;26:7014-21 pubmed
    ..Although GluR5-7 can exist as functional homomeric channels, the KA subunits cannot. KA2 is widely expressed in the CNS, and KA2/GluR6 heteromers are the most prevalent subunit composition in brain...
  3. Fisahn A, Contractor A, Traub R, Buhl E, Heinemann S, McBain C. Distinct roles for the kainate receptor subunits GluR5 and GluR6 in kainate-induced hippocampal gamma oscillations. J Neurosci. 2004;24:9658-68 pubmed
  4. Sachidhanandam S, Blanchet C, Jeantet Y, Cho Y, Mulle C. Kainate receptors act as conditional amplifiers of spike transmission at hippocampal mossy fiber synapses. J Neurosci. 2009;29:5000-8 pubmed publisher
    ..By analyzing mice deficient for GluK2 (GluR6), GluK3 (GluR7) and GluK5 (KA2) genes we show that kainate receptors (KARs) play a crucial role in the control of synaptic integration and ..
  5. Kayadjanian N, Lee H, Piña Crespo J, Heinemann S. Localization of glutamate receptors to distal dendrites depends on subunit composition and the kinesin motor protein KIF17. Mol Cell Neurosci. 2007;34:219-30 pubmed
    ..We find that the GluR5 distribution depends on association with GluR6 and KA2 subunits...
  6. Hirano T, Kasono K, Araki K, Mishina M. Suppression of LTD in cultured Purkinje cells deficient in the glutamate receptor delta 2 subunit. Neuroreport. 1995;6:524-6 pubmed
    ..The results indicate that the glutamate receptor channel delta 2 subunit is involved in the postsynaptic down-regulation of glutamate sensitivity, presumably during cerebellar LTD. ..
  7. Yan D, Yamasaki M, Straub C, Watanabe M, Tomita S. Homeostatic control of synaptic transmission by distinct glutamate receptors. Neuron. 2013;78:687-99 pubmed publisher
    ..of AMPA receptor activity is required for spike generation and is mediated by the increased expression of the GluK5 high-affinity kainate receptor subunit...
  8. Miyazaki T, Hashimoto K, Uda A, Sakagami H, Nakamura Y, Saito S, et al. Disturbance of cerebellar synaptic maturation in mutant mice lacking BSRPs, a novel brain-specific receptor-like protein family. FEBS Lett. 2006;580:4057-64 pubmed
    ..Because cerebellar maturation and plasticity require metabotropic glutamate receptor signaling and resulting PKC activation, BSRPs are likely involved in ER functions supporting PKCalpha activation in PCs. ..
  9. Kohda K, Kamiya Y, Matsuda S, Kato K, Umemori H, Yuzaki M. Heteromer formation of delta2 glutamate receptors with AMPA or kainate receptors. Brain Res Mol Brain Res. 2003;110:27-37 pubmed
    ..were partially co-immunoprecipitated from cerebellar synaptosomal fractions by antibodies against GluR2 or KA2. In contrast to lurcher channels, expression of wild-type GluRdelta2 significantly reduced the glutamate-induced ..

More Information


  1. Myers S, Dingledine R, Borges K. Genetic regulation of glutamate receptor ion channels. Annu Rev Pharmacol Toxicol. 1999;39:221-41 pubmed
    ..The promoters of the genes that encode the NR1, NR2B, NR2C, GluR1, GluR2, and KA2 subunits share several characteristics that include multiple transcriptional start sites within a CpG island, lack ..
  2. Templin J, Bang S, Soiza Reilly M, Berde C, Commons K. Patterned expression of ion channel genes in mouse dorsal raphe nucleus determined with the Allen Mouse Brain Atlas. Brain Res. 2012;1457:1-12 pubmed publisher
    ..The identified genes likely contribute to unique excitable properties of different groups of neurons in the DR and may include novel pharmacologic targets for affective disorders. ..
  3. Coussen F. Molecular determinants of kainate receptor trafficking. Neuroscience. 2009;158:25-35 pubmed publisher
  4. Jane D, Lodge D, Collingridge G. Kainate receptors: pharmacology, function and therapeutic potential. Neuropharmacology. 2009;56:90-113 pubmed publisher
    ..This potential has now been confirmed in dental pain and migraine in initial studies in man. ..
  5. Cui S, Du P, Zhou X, Wang H. Developmental expression patterns of kainate receptors in the mouse spinal cord. Neuroreport. 2012;23:1012-6 pubmed publisher
    ..At E16.5, Grik2 and Grik3 were mainly expressed in the dorsal horns whereas Grik5 was expressed in the entire spinal cord...
  6. Sakimura K, Morita T, Kushiya E, Mishina M. Primary structure and expression of the gamma 2 subunit of the glutamate receptor channel selective for kainate. Neuron. 1992;8:267-74 pubmed
    ..Expression of the gamma 2 subunit together with the beta 2 subunit in Xenopus oocytes yields functional glutamate receptor channels selective for kainate. ..
  7. Catches J, Xu J, Contractor A. Genetic ablation of the GluK4 kainate receptor subunit causes anxiolytic and antidepressant-like behavior in mice. Behav Brain Res. 2012;228:406-14 pubmed publisher
  8. Vernon C, Swanson G. Neto2 Assembles with Kainate Receptors in DRG Neurons during Development and Modulates Neurite Outgrowth in Adult Sensory Neurons. J Neurosci. 2017;37:3352-3363 pubmed publisher
  9. Vivithanaporn P, Yan S, Swanson G. Intracellular trafficking of KA2 kainate receptors mediated by interactions with coatomer protein complex I (COPI) and 14-3-3 chaperone systems. J Biol Chem. 2006;281:15475-84 pubmed
    ..protein complex I (COPI) vesicle coat as a critical mechanism for retention of the kainate receptor subunit KA2 in the endoplasmic reticulum...
  10. Darstein M, Petralia R, Swanson G, Wenthold R, Heinemann S. Distribution of kainate receptor subunits at hippocampal mossy fiber synapses. J Neurosci. 2003;23:8013-9 pubmed
    ..We provide morphological evidence for the presynaptic localization of KA1 and KA2 receptor subunits at mossy fiber synapses...
  11. Contractor A, Sailer A, Darstein M, Maron C, Xu J, Swanson G, et al. Loss of kainate receptor-mediated heterosynaptic facilitation of mossy-fiber synapses in KA2-/- mice. J Neurosci. 2003;23:422-9 pubmed
    ..The KA2 subunit is a likely constituent of many neuronal kainate receptors, because it is widely expressed in most neurons ..
  12. Kerchner G, Wilding T, Huettner J, Zhuo M. Kainate receptor subunits underlying presynaptic regulation of transmitter release in the dorsal horn. J Neurosci. 2002;22:8010-7 pubmed
    ..These results highlight fundamental differences in KA receptor physiology between the two cell types and suggest possible strategies for the pharmacological modulation of nociception. ..
  13. Jabłońska B, Smith A, Kossut M, Skangiel Kramska J. Development of laminar distributions of kainate receptors in the somatosensory cortex of mice. Brain Res. 1998;791:325-9 pubmed
    ..The sharp increase of kainate receptor during the first postnatal week coincides with the critical period for cytoarchitectonic plasticity of the barrels and establishment of functional thalamo-cortical connections in the barrel field. ..
  14. Zhang C, Hammassaki Britto D, Britto L, Duvoisin R. Expression of glutamate receptor subunit genes during development of the mouse retina. Neuroreport. 1996;8:335-40 pubmed
    ..This suggests they play a role in the processes of neuronal differentiation and synaptogenesis that occur during the early postnatal days in the rodent retina. ..
  15. Szpirer C, Molné M, Antonacci R, Jenkins N, Finelli P, Szpirer J, et al. The genes encoding the glutamate receptor subunits KA1 and KA2 (GRIK4 and GRIK5) are located on separate chromosomes in human, mouse, and rat. Proc Natl Acad Sci U S A. 1994;91:11849-53 pubmed
    ..of the human and rat genes encoding the kainate-preferring glutamate receptor subunits KA1 and KA2 (GRIK4 and GRIK5, respectively) was determined by Southern analysis of rat x mouse and human x mouse somatic cell hybrid panels and ..
  16. Rebola N, Sachidhanandam S, Perrais D, Cunha R, Mulle C. Short-term plasticity of kainate receptor-mediated EPSCs induced by NMDA receptors at hippocampal mossy fiber synapses. J Neurosci. 2007;27:3987-93 pubmed
    ..Hence, this study describes a form of short-term synaptic plasticity that is postsynaptic, depends on the temporal order of presynaptic and postsynaptic spiking, and likely affects the summation properties of mossy fiber EPSPs. ..
  17. Ruiz A, Sachidhanandam S, Utvik J, Coussen F, Mulle C. Distinct subunits in heteromeric kainate receptors mediate ionotropic and metabotropic function at hippocampal mossy fiber synapses. J Neurosci. 2005;25:11710-8 pubmed
    Heteromeric kainate receptors (KARs) containing both glutamate receptor 6 (GluR6) and KA2 subunits are involved in KAR-mediated EPSCs at mossy fiber synapses in CA3 pyramidal cells...
  18. Fernandes H, Catches J, Petralia R, Copits B, Xu J, Russell T, et al. High-affinity kainate receptor subunits are necessary for ionotropic but not metabotropic signaling. Neuron. 2009;63:818-29 pubmed publisher
    Kainate receptors signal through both ionotropic and metabotropic pathways. The high-affinity subunits, GluK4 and GluK5, are unique among the five receptor subunits, as they do not form homomeric receptors but modify the properties of ..
  19. Fujikawa T, Petralia R, Fitzgerald T, Wang Y, Millis B, Morgado Díaz J, et al. Localization of kainate receptors in inner and outer hair cell synapses. Hear Res. 2014;314:20-32 pubmed publisher
    ..KARs are expressed in hair cell synapses, we performed X-gal staining on mice expressing lacZ driven by the GluK5 promoter, and immunolabeling of glutamate receptors in whole-mount mammalian cochleae...