Gene Symbol: Grid1
Description: glutamate receptor, ionotropic, delta 1
Alias: GluD1, GluRdelta1, glutamate receptor ionotropic, delta-1, gluR delta-1 subunit, glutamate receptor delta-1 subunit
Species: mouse
Products:     Grid1

Top Publications

  1. Yasumura M, Yoshida T, Lee S, Uemura T, Joo J, Mishina M. Glutamate receptor ?1 induces preferentially inhibitory presynaptic differentiation of cortical neurons by interacting with neurexins through cerebellin precursor protein subtypes. J Neurochem. 2012;121:705-16 pubmed publisher
  2. Yadav R, Gupta S, Hillman B, Bhatt J, Stairs D, Dravid S. Deletion of glutamate delta-1 receptor in mouse leads to aberrant emotional and social behaviors. PLoS ONE. 2012;7:e32969 pubmed publisher
    ..Furthermore, these findings are in agreement with the human genetic studies suggesting a strong association of GRID1 gene with several neuropsychiatric disorders including schizophrenia, bipolar disorder, autism spectrum disorders ..
  3. Gao J, Maison S, Wu X, Hirose K, Jones S, Bayazitov I, et al. Orphan glutamate receptor delta1 subunit required for high-frequency hearing. Mol Cell Biol. 2007;27:4500-12 pubmed
    The function of the orphan glutamate receptor delta subunits (GluRdelta1 and GluRdelta2) remains unclear...
  4. Yue Z, Horton A, Bravin M, DeJager P, Selimi F, Heintz N. A novel protein complex linking the delta 2 glutamate receptor and autophagy: implications for neurodegeneration in lurcher mice. Neuron. 2002;35:921-33 pubmed
    ..These results provide strong evidence that a direct link exists between GluRdelta2(Lc) receptor and stimulation of the autophagic pathway in dying lurcher Purkinje cells. ..
  5. Yadav R, Rimerman R, Scofield M, Dravid S. Mutations in the transmembrane domain M3 generate spontaneously open orphan glutamate ?1 receptor. Brain Res. 2011;1382:1-8 pubmed publisher
    ..These results suggest that the activation gate is conserved in GluR?1 receptors. Moreover, the conformational changes induced by d-serine and extracellular Ca(2+) are conserved among GluR?1 and GluR?2 receptors. ..
  6. Yamazaki M, Araki K, Shibata A, Mishina M. Molecular cloning of a cDNA encoding a novel member of the mouse glutamate receptor channel family. Biochem Biophys Res Commun. 1992;183:886-92 pubmed
    ..The delta 1 subunit shows 21-25% amino acid sequence identity with previously characterized rodent glutamate receptor channel subunits and thus may represent a new subfamily of the glutamate receptor channel. ..
  7. Hain H, Crabbe J, Bergeson S, Belknap J. Cocaine-induced seizure thresholds: quantitative trait loci detection and mapping in two populations derived from the C57BL/6 and DBA/2 mouse strains. J Pharmacol Exp Ther. 2000;293:180-7 pubmed
    ..0015), both associated with clonic seizures on chromosomes 9 (proximal) and 15 (distal). Both QTLs on chromosome 9 were sex-specific, with much larger effects on the phenotype seen in females than in males. ..
  8. Konno K, Matsuda K, Nakamoto C, Uchigashima M, Miyazaki T, Yamasaki M, et al. Enriched expression of GluD1 in higher brain regions and its involvement in parallel fiber-interneuron synapse formation in the cerebellum. J Neurosci. 2014;34:7412-24 pubmed publisher
    ..However, little is known to date regarding cellular and synaptic expression of GluD1 and its role in synaptic circuit formation...
  9. Suryavanshi P, Gupta S, Yadav R, Kesherwani V, Liu J, Dravid S. Glutamate Delta-1 Receptor Regulates Metabotropic Glutamate Receptor 5 Signaling in the Hippocampus. Mol Pharmacol. 2016;90:96-105 pubmed publisher
    The delta family of ionotropic glutamate receptors consists of glutamate delta-1 (GluD1) and glutamate delta-2 receptors...

More Information


  1. Elegheert J, Kakegawa W, Clay J, Shanks N, Behiels E, Matsuda K, et al. Structural basis for integration of GluD receptors within synaptic organizer complexes. Science. 2016;353:295-9 pubmed publisher
    ..These results lead to a model where protein and small-molecule ligands synergistically control synaptic iGluR function. ..
  2. Treadaway J, Zuo J. Mapping of the mouse glutamate receptor delta1 subunit (Grid1) to chromosome 14. Genomics. 1998;54:359-60 pubmed
  3. Rasmussen E, Cipp L, Hitzemann R. Identification of quantitative trait loci for haloperidol-induced catalepsy on mouse chromosome 14. J Pharmacol Exp Ther. 1999;290:1337-46 pubmed
    ..9), which was located more proximally and included the Chat locus. No QTLs were detected on chromosomes 1 and 9, thus differentiating this cross from previous results obtained for a C57BL/6J x DBA/2J intercross...
  4. Yadav R, Hillman B, Gupta S, Suryavanshi P, Bhatt J, Pavuluri R, et al. Deletion of glutamate delta-1 receptor in mouse leads to enhanced working memory and deficit in fear conditioning. PLoS ONE. 2013;8:e60785 pubmed publisher
    Glutamate delta-1 (GluD1) receptors are expressed throughout the forebrain during development with high levels in the hippocampus during adulthood...