Gria1

Summary

Gene Symbol: Gria1
Description: glutamate receptor, ionotropic, AMPA1 (alpha 1)
Alias: 2900051M01Rik, Glr-1, Glr1, GluA1, GluR-A, GluRA, Glur-1, Glur1, HIPA1, gluR-K1, glutamate receptor 1, AMPA-selective glutamate receptor 1, glutamate receptor A, glutamate receptor ionotropic, AMPA 1
Species: mouse
Products:     Gria1

Top Publications

  1. Maghsoodi B, Poon M, Nam C, Aoto J, Ting P, Chen L. Retinoic acid regulates RARalpha-mediated control of translation in dendritic RNA granules during homeostatic synaptic plasticity. Proc Natl Acad Sci U S A. 2008;105:16015-20 pubmed publisher
    ..transmission by stimulating in dendrites the local translation and synaptic insertion of the AMPA receptor subunit GluR1. We have previously shown that all-trans retinoic acid (RA) mediates activity blockade-induced synaptic scaling by ..
  2. Hardingham N, Fox K. The role of nitric oxide and GluR1 in presynaptic and postsynaptic components of neocortical potentiation. J Neurosci. 2006;26:7395-404 pubmed
    ..AMPA receptor subunit 1 (GluR1) knock-out mice also showed LTP in this pathway, but potentiation was predominantly presynaptic in origin as ..
  3. Fuchs E, Zivkovic A, Cunningham M, Middleton S, LeBeau F, Bannerman D, et al. Recruitment of parvalbumin-positive interneurons determines hippocampal function and associated behavior. Neuron. 2007;53:591-604 pubmed
    ..These findings directly show the effects of insufficient recruitment of fast-spiking cells at the network and behavioral level and demonstrate the role of this subpopulation for working and episodic-like memory. ..
  4. Sanderson D, Gray A, Simon A, Taylor A, Deacon R, Seeburg P, et al. Deletion of glutamate receptor-A (GluR-A) AMPA receptor subunits impairs one-trial spatial memory. Behav Neurosci. 2007;121:559-69 pubmed
    Genetically modified mice lacking the glutamate receptor A (GluR-A) subunit of the AMPA receptor (GluR-A-/- mice) display normal spatial reference memory but impaired spatial working memory (SWM)...
  5. Seol G, Ziburkus J, Huang S, Song L, Kim I, Takamiya K, et al. Neuromodulators control the polarity of spike-timing-dependent synaptic plasticity. Neuron. 2007;55:919-29 pubmed
    ..These findings indicate that cholinergic and adrenergic neuromodulation associated with the behavioral state of the animal can control the gating and the polarity of cortical plasticity. ..
  6. Frey M, Sprengel R, Nevian T. Activity pattern-dependent long-term potentiation in neocortex and hippocampus of GluA1 (GluR-A) subunit-deficient mice. J Neurosci. 2009;29:5587-96 pubmed publisher
    The AMPA receptor subunit GluA1 (GluR-A) has been implicated to be critically involved in the expression of long-term potentiation (LTP) and memory formation. Mice lacking this subunit possess a profound spatial working memory deficit...
  7. Hayashi T, Rumbaugh G, Huganir R. Differential regulation of AMPA receptor subunit trafficking by palmitoylation of two distinct sites. Neuron. 2005;47:709-23 pubmed
    ..These data suggest that regulated palmitoylation of AMPA receptor subunits modulates receptor trafficking and may be important for synaptic plasticity. ..
  8. Hu H, Real E, Takamiya K, Kang M, LeDoux J, Huganir R, et al. Emotion enhances learning via norepinephrine regulation of AMPA-receptor trafficking. Cell. 2007;131:160-73 pubmed
    ..Toward this aim, we have examined the role of NE in contextual memory formation and in the synaptic delivery of GluR1-containing alpha-amino-3-hydroxy-5-methyl-4-isoxazoleproprionic acid (AMPA)-type glutamate receptors during long-..
  9. Wang H, Wu L, Kim S, Lee F, Gong B, Toyoda H, et al. FMRP acts as a key messenger for dopamine modulation in the forebrain. Neuron. 2008;59:634-47 pubmed publisher
    ..AMPA glutamate receptor subtype 1 (GluR1) surface expression and phosphorylation in response to D1 receptor stimulation were reduced in cultured Fmr1(-/-) ..
  10. Johnson A, Bannerman D, Rawlins N, Sprengel R, Good M. Impaired outcome-specific devaluation of instrumental responding in mice with a targeted deletion of the AMPA receptor glutamate receptor 1 subunit. J Neurosci. 2005;25:2359-65 pubmed
    The present study evaluated the proposal that mice with a targeted deletion of the glutamate receptor 1 (GluR1) subunit of the AMPA receptor are impaired in using an instrumental or pavlovian signal to gain access to a representation of ..

Detail Information

Publications68

  1. Maghsoodi B, Poon M, Nam C, Aoto J, Ting P, Chen L. Retinoic acid regulates RARalpha-mediated control of translation in dendritic RNA granules during homeostatic synaptic plasticity. Proc Natl Acad Sci U S A. 2008;105:16015-20 pubmed publisher
    ..transmission by stimulating in dendrites the local translation and synaptic insertion of the AMPA receptor subunit GluR1. We have previously shown that all-trans retinoic acid (RA) mediates activity blockade-induced synaptic scaling by ..
  2. Hardingham N, Fox K. The role of nitric oxide and GluR1 in presynaptic and postsynaptic components of neocortical potentiation. J Neurosci. 2006;26:7395-404 pubmed
    ..AMPA receptor subunit 1 (GluR1) knock-out mice also showed LTP in this pathway, but potentiation was predominantly presynaptic in origin as ..
  3. Fuchs E, Zivkovic A, Cunningham M, Middleton S, LeBeau F, Bannerman D, et al. Recruitment of parvalbumin-positive interneurons determines hippocampal function and associated behavior. Neuron. 2007;53:591-604 pubmed
    ..These findings directly show the effects of insufficient recruitment of fast-spiking cells at the network and behavioral level and demonstrate the role of this subpopulation for working and episodic-like memory. ..
  4. Sanderson D, Gray A, Simon A, Taylor A, Deacon R, Seeburg P, et al. Deletion of glutamate receptor-A (GluR-A) AMPA receptor subunits impairs one-trial spatial memory. Behav Neurosci. 2007;121:559-69 pubmed
    Genetically modified mice lacking the glutamate receptor A (GluR-A) subunit of the AMPA receptor (GluR-A-/- mice) display normal spatial reference memory but impaired spatial working memory (SWM)...
  5. Seol G, Ziburkus J, Huang S, Song L, Kim I, Takamiya K, et al. Neuromodulators control the polarity of spike-timing-dependent synaptic plasticity. Neuron. 2007;55:919-29 pubmed
    ..These findings indicate that cholinergic and adrenergic neuromodulation associated with the behavioral state of the animal can control the gating and the polarity of cortical plasticity. ..
  6. Frey M, Sprengel R, Nevian T. Activity pattern-dependent long-term potentiation in neocortex and hippocampus of GluA1 (GluR-A) subunit-deficient mice. J Neurosci. 2009;29:5587-96 pubmed publisher
    The AMPA receptor subunit GluA1 (GluR-A) has been implicated to be critically involved in the expression of long-term potentiation (LTP) and memory formation. Mice lacking this subunit possess a profound spatial working memory deficit...
  7. Hayashi T, Rumbaugh G, Huganir R. Differential regulation of AMPA receptor subunit trafficking by palmitoylation of two distinct sites. Neuron. 2005;47:709-23 pubmed
    ..These data suggest that regulated palmitoylation of AMPA receptor subunits modulates receptor trafficking and may be important for synaptic plasticity. ..
  8. Hu H, Real E, Takamiya K, Kang M, LeDoux J, Huganir R, et al. Emotion enhances learning via norepinephrine regulation of AMPA-receptor trafficking. Cell. 2007;131:160-73 pubmed
    ..Toward this aim, we have examined the role of NE in contextual memory formation and in the synaptic delivery of GluR1-containing alpha-amino-3-hydroxy-5-methyl-4-isoxazoleproprionic acid (AMPA)-type glutamate receptors during long-..
  9. Wang H, Wu L, Kim S, Lee F, Gong B, Toyoda H, et al. FMRP acts as a key messenger for dopamine modulation in the forebrain. Neuron. 2008;59:634-47 pubmed publisher
    ..AMPA glutamate receptor subtype 1 (GluR1) surface expression and phosphorylation in response to D1 receptor stimulation were reduced in cultured Fmr1(-/-) ..
  10. Johnson A, Bannerman D, Rawlins N, Sprengel R, Good M. Impaired outcome-specific devaluation of instrumental responding in mice with a targeted deletion of the AMPA receptor glutamate receptor 1 subunit. J Neurosci. 2005;25:2359-65 pubmed
    The present study evaluated the proposal that mice with a targeted deletion of the glutamate receptor 1 (GluR1) subunit of the AMPA receptor are impaired in using an instrumental or pavlovian signal to gain access to a representation of ..
  11. Wang X, MCCOY P, Rodriguiz R, Pan Y, Je H, Roberts A, et al. Synaptic dysfunction and abnormal behaviors in mice lacking major isoforms of Shank3. Hum Mol Genet. 2011;20:3093-108 pubmed publisher
    ..Shank3(e4-9) mice have reduced levels of Homer1b/c, GKAP and GluA1 at the PSD, and show attenuated activity-dependent redistribution of GluA1-containing AMPA receptors...
  12. Lu W, Shi Y, Jackson A, Bjorgan K, During M, Sprengel R, et al. Subunit composition of synaptic AMPA receptors revealed by a single-cell genetic approach. Neuron. 2009;62:254-68 pubmed publisher
    ..is of particular importance with regard to AMPA-type glutamate receptors, the multimeric complexes assembled from GluA1-A4 subunits, as the trafficking of these receptors into and out of synapses is proposed to depend upon the subunit ..
  13. Milstein A, Nicoll R. TARP modulation of synaptic AMPA receptor trafficking and gating depends on multiple intracellular domains. Proc Natl Acad Sci U S A. 2009;106:11348-51 pubmed publisher
  14. He K, Song L, Cummings L, Goldman J, Huganir R, Lee H. Stabilization of Ca2+-permeable AMPA receptors at perisynaptic sites by GluR1-S845 phosphorylation. Proc Natl Acad Sci U S A. 2009;106:20033-8 pubmed publisher
    ..Certain types of neural activity can recruit Ca(2+)-permeable (CP) AMPARs, such as GluR1 homomers, to synapses likely via lateral diffusion from extrasynaptic sites...
  15. Mead A, Stephens D. Selective disruption of stimulus-reward learning in glutamate receptor gria1 knock-out mice. J Neurosci. 2003;23:1041-8 pubmed
    ..AMPA receptor glutamate receptor 1 (GluR1) subunits play a critical role in long-term potentiation (LTP)...
  16. Wiedholz L, Owens W, Horton R, Feyder M, Karlsson R, Hefner K, et al. Mice lacking the AMPA GluR1 receptor exhibit striatal hyperdopaminergia and 'schizophrenia-related' behaviors. Mol Psychiatry. 2008;13:631-40 pubmed
    ..study evaluated knockout (KO) mice lacking the L-alpha-amino-3-hydroxy-5-methylisoxazole-4-propionate (AMPA) GluR1 receptor subunit for a range of behaviors considered relevant to certain symptoms of schizophrenia...
  17. Goel A, Xu L, Snyder K, Song L, Goenaga Vazquez Y, Megill A, et al. Phosphorylation of AMPA receptors is required for sensory deprivation-induced homeostatic synaptic plasticity. PLoS ONE. 2011;6:e18264 pubmed publisher
    ..scaling in visual cortex of juvenile rodents, is accompanied by an increase in the phosphorylation of AMPAR GluR1 (or GluA1) subunit at the serine 845 (S845) site and the appearance of CP-AMPARs at synapses...
  18. Lee H, Takamiya K, He K, Song L, Huganir R. Specific roles of AMPA receptor subunit GluR1 (GluA1) phosphorylation sites in regulating synaptic plasticity in the CA1 region of hippocampus. J Neurophysiol. 2010;103:479-89 pubmed publisher
    ..In particular, several lines of evidence suggest that reversible phosphorylation of AMPAR subunit glutamate receptor 1 (GluR1, also referred to as GluA1 or GluR-A) plays a role in long-term potentiation (LTP) and long-term ..
  19. Sanderson D, McHugh S, Good M, Sprengel R, Seeburg P, Rawlins J, et al. Spatial working memory deficits in GluA1 AMPA receptor subunit knockout mice reflect impaired short-term habituation: evidence for Wagner's dual-process memory model. Neuropsychologia. 2010;48:2303-15 pubmed publisher
    Genetically modified mice, lacking the GluA1 AMPA receptor subunit, are impaired on spatial working memory tasks, but display normal acquisition of spatial reference memory tasks...
  20. Bliss T, Collingridge G. A synaptic model of memory: long-term potentiation in the hippocampus. Nature. 1993;361:31-9 pubmed
  21. Schmitt W, Deacon R, Seeburg P, Rawlins J, Bannerman D. A within-subjects, within-task demonstration of intact spatial reference memory and impaired spatial working memory in glutamate receptor-A-deficient mice. J Neurosci. 2003;23:3953-9 pubmed
    Gene-targeted mice lacking the AMPA receptor subunit glutamate receptor-A (GluRA) (GluR1) and wild-type controls were compared on a radial-maze task in which the same three of six arms were always baited, but in which the rewards of milk ..
  22. Romberg C, Raffel J, Martin L, Sprengel R, Seeburg P, Rawlins J, et al. Induction and expression of GluA1 (GluR-A)-independent LTP in the hippocampus. Eur J Neurosci. 2009;29:1141-52 pubmed publisher
    ..Here we used genetically modified mice lacking the GluA1 subunit (Gria1(-/-) mice) to investigate GluA1-independent mechanisms of LTP at CA3-CA1 synapses in transverse hippocampal slices...
  23. Altimimi H, Stellwagen D. Persistent synaptic scaling independent of AMPA receptor subunit composition. J Neurosci. 2013;33:11763-7 pubmed publisher
    ..Similar to LTP, the GluA1 subunit has been suggested to be the requisite subunit for HSP-induced AMPAR insertion and acute treatment with ..
  24. Barkus C, Feyder M, Graybeal C, Wright T, Wiedholz L, Izquierdo A, et al. Do GluA1 knockout mice exhibit behavioral abnormalities relevant to the negative or cognitive symptoms of schizophrenia and schizoaffective disorder?. Neuropharmacology. 2012;62:1263-72 pubmed publisher
    ..We recently found that knockout (KO) mice lacking the AMPA GluA1 subunit displayed behavioral abnormalities relevant to some of the positive symptoms of these disorders...
  25. Sanderson D, Sprengel R, Seeburg P, Bannerman D. Deletion of the GluA1 AMPA receptor subunit alters the expression of short-term memory. Learn Mem. 2011;18:128-31 pubmed publisher
    Deletion of the GluA1 AMPA receptor subunit selectively impairs short-term memory for spatial locations. We further investigated this deficit by examining memory for discrete nonspatial visual stimuli in an operant chamber...
  26. Fitzgerald P, Barkus C, Feyder M, Wiedholz L, Chen Y, Karlsson R, et al. Does gene deletion of AMPA GluA1 phenocopy features of schizoaffective disorder?. Neurobiol Dis. 2010;40:608-21 pubmed publisher
    Glutamatergic dysfunction is strongly implicated in schizophrenia and mood disorders. GluA1 knockout (KO) mice display schizophrenia- and depression-related abnormalities. Here, we asked whether GluA1 KO show mania-related abnormalities...
  27. Mack V, Burnashev N, Kaiser K, Rozov A, Jensen V, Hvalby O, et al. Conditional restoration of hippocampal synaptic potentiation in Glur-A-deficient mice. Science. 2001;292:2501-4 pubmed
    ..is dependent on l-alpha-amino-3-hydroxy-5-methylisoxazole-4-propionate (AMPA) receptors containing the glutamate receptor A (GluR-A) subunit...
  28. Schmitt W, Sprengel R, Mack V, Draft R, Seeburg P, Deacon R, et al. Restoration of spatial working memory by genetic rescue of GluR-A-deficient mice. Nat Neurosci. 2005;8:270-2 pubmed
    Gene-targeted mice lacking the AMPA receptor subunit GluR-A (also called GluR1 encoded by the gene Gria1,) have deficits in hippocampal CA3-CA1 long-term potentiation (LTP) and have profoundly impaired hippocampus-dependent spatial ..
  29. Sanderson D, Hindley E, Smeaton E, Denny N, Taylor A, Barkus C, et al. Deletion of the GluA1 AMPA receptor subunit impairs recency-dependent object recognition memory. Learn Mem. 2011;18:181-90 pubmed publisher
    Deletion of the GluA1 AMPA receptor subunit impairs short-term spatial recognition memory...
  30. Humeau Y, Reisel D, Johnson A, Borchardt T, Jensen V, Gebhardt C, et al. A pathway-specific function for different AMPA receptor subunits in amygdala long-term potentiation and fear conditioning. J Neurosci. 2007;27:10947-56 pubmed
    The AMPA receptor subunit glutamate receptor 1 (GluR1 or GluR-A) contributes to amygdala-dependent emotional learning...
  31. Lin D, Makino Y, Sharma K, Hayashi T, Neve R, Takamiya K, et al. Regulation of AMPA receptor extrasynaptic insertion by 4.1N, phosphorylation and palmitoylation. Nat Neurosci. 2009;12:879-87 pubmed publisher
    ..By directly visualizing individual insertion events of the AMPAR subunit GluR1 in rodents, we found that the protein 4.1N was required for activity-dependent GluR1 insertion...
  32. Volk L, Daly C, Huber K. Differential roles for group 1 mGluR subtypes in induction and expression of chemically induced hippocampal long-term depression. J Neurophysiol. 2006;95:2427-38 pubmed
    ..This suggests different receptors and/or upstream mechanisms for chemically and synaptically induced LTD...
  33. Nabavi S, Kessels H, Alfonso S, Aow J, Fox R, Malinow R. Metabotropic NMDA receptor function is required for NMDA receptor-dependent long-term depression. Proc Natl Acad Sci U S A. 2013;110:4027-32 pubmed publisher
    ..Our findings indicate that metabotropic actions of NMDARs can weaken active synapses without raising postsynaptic calcium, thereby revising and expanding the mechanisms controlling synaptic plasticity. ..
  34. Vekovischeva O, Zamanillo D, Echenko O, Seppala T, Uusi Oukari M, Honkanen A, et al. Morphine-induced dependence and sensitization are altered in mice deficient in AMPA-type glutamate receptor-A subunits. J Neurosci. 2001;21:4451-9 pubmed
    ..The results indicate that AMPA receptors are involved in the acute and chronic effects of morphine, including context-independent sensitization, and that the GluR-A subunit itself is important for morphine tolerance and dependence. ..
  35. Erickson M, Maramara L, Lisman J. A single brief burst induces GluR1-dependent associative short-term potentiation: a potential mechanism for short-term memory. J Cogn Neurosci. 2010;22:2530-40 pubmed publisher
    Recent work showed that short-term memory (STM) is selectively reduced in GluR1 knockout mice. This raises the possibility that a form of synaptic modification dependent on GluR1 might underlie STM...
  36. Engblom D, Bilbao A, Sanchis Segura C, Dahan L, Perreau Lenz S, Balland B, et al. Glutamate receptors on dopamine neurons control the persistence of cocaine seeking. Neuron. 2008;59:497-508 pubmed publisher
    Cocaine strengthens excitatory synapses onto midbrain dopamine neurons through the synaptic delivery of GluR1-containing AMPA receptors...
  37. Clem R, Huganir R. Calcium-permeable AMPA receptor dynamics mediate fear memory erasure. Science. 2010;330:1108-12 pubmed publisher
    ..A transient up-regulation of this form of plasticity, which involves phosphorylation of the glutamate receptor 1 subunit of the AMPA receptor, defines a temporal window in which fear memory can be degraded by behavioral ..
  38. Procaccini C, Aitta Aho T, Jaako Movits K, Zharkovsky A, Panhelainen A, Sprengel R, et al. Excessive novelty-induced c-Fos expression and altered neurogenesis in the hippocampus of GluA1 knockout mice. Eur J Neurosci. 2011;33:161-74 pubmed publisher
    Amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptor GluA1 subunit-deficient (GluA1-/-) mice display novelty-induced hyperactivity, cognitive and social defects and may model psychiatric disorders, such as schizophrenia ..
  39. Reisel D, Bannerman D, Schmitt W, Deacon R, Flint J, Borchardt T, et al. Spatial memory dissociations in mice lacking GluR1. Nat Neurosci. 2002;5:868-73 pubmed
    Gene-targeted mice lacking the AMPA receptor subunit GluR1 (GluR-A) have deficits in hippocampal CA3-CA1 long-term potentiation...
  40. Schmitt W, Arianpour R, Deacon R, Seeburg P, Sprengel R, Rawlins J, et al. The role of hippocampal glutamate receptor-A-dependent synaptic plasticity in conditional learning: the importance of spatiotemporal discontiguity. J Neurosci. 2004;24:7277-82 pubmed
    Gene-targeted mice lacking the AMPA receptor subunit glutamate receptor-A (GluR-A or GluR1) and mice with cytotoxic hippocampal lesions were compared with wild-type and sham-operated controls, respectively, on a conditional learning task ..
  41. Lee H, Takamiya K, Han J, Man H, Kim C, Rumbaugh G, et al. Phosphorylation of the AMPA receptor GluR1 subunit is required for synaptic plasticity and retention of spatial memory. Cell. 2003;112:631-43 pubmed
    ..We previously reported that phosphorylation of the GluR1 subunit of AMPA receptors, which mediate rapid excitatory transmission in the brain, is modulated during LTP and ..
  42. Lee H, Takamiya K, Kameyama K, He K, Yu S, Rossetti L, et al. Identification and characterization of a novel phosphorylation site on the GluR1 subunit of AMPA receptors. Mol Cell Neurosci. 2007;36:86-94 pubmed
    ..Here, we identified threonine-840 (T840) on the GluR1 subunit of AMPA receptors as a novel phosphorylation site...
  43. Sans N, Vissel B, Petralia R, Wang Y, Chang K, Royle G, et al. Aberrant formation of glutamate receptor complexes in hippocampal neurons of mice lacking the GluR2 AMPA receptor subunit. J Neurosci. 2003;23:9367-73 pubmed
    ..Our data indicate that in the absence of GluR2, aberrant receptor complexes composed of GluR1 and GluR3 are formed in the hippocampus, and that there is an increased number of homomeric GluR1 and GluR3 ..
  44. Schmitt W, Deacon R, Reisel D, Sprengel R, Seeburg P, Rawlins J, et al. Spatial reference memory in GluR-A-deficient mice using a novel hippocampal-dependent paddling pool escape task. Hippocampus. 2004;14:216-23 pubmed
    ..modified mice lacking the L-alpha-amino-3-hydroxy-5-methylisoxazole-4-propionate (AMPA) receptor subunit, GluR-A (GluR1), and deficient in hippocampal CA3-CA1 long-term potentiation (LTP), were assessed on a novel, hippocampal-..
  45. Vekovischeva O, Aitta Aho T, Echenko O, Kankaanpää A, Seppala T, Honkanen A, et al. Reduced aggression in AMPA-type glutamate receptor GluR-A subunit-deficient mice. Genes Brain Behav. 2004;3:253-65 pubmed
  46. Phillips K, Hardingham N, Fox K. Postsynaptic action potentials are required for nitric-oxide-dependent long-term potentiation in CA1 neurons of adult GluR1 knock-out and wild-type mice. J Neurosci. 2008;28:14031-41 pubmed publisher
    ..potentiation (LTP) consists of both presynaptic and postsynaptic components that rely on nitric oxide (NO) and the GluR1 subunit of the AMPA receptor, respectively...
  47. Procaccini C, Maksimovic M, Aitta Aho T, Korpi E, Linden A. Reversal of novelty-induced hyperlocomotion and hippocampal c-Fos expression in GluA1 knockout male mice by the mGluR2/3 agonist LY354740. Neuroscience. 2013;250:189-200 pubmed publisher
    ..As a putative model for these disorders, a mouse line lacking the GluA1 subunit (GluA1-KO) of the ?-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) glutamate receptor displays ..
  48. Nakajima C, Kulik A, Frotscher M, Herz J, Schafer M, Bock H, et al. Low density lipoprotein receptor-related protein 1 (LRP1) modulates N-methyl-D-aspartate (NMDA) receptor-dependent intracellular signaling and NMDA-induced regulation of postsynaptic protein complexes. J Biol Chem. 2013;288:21909-23 pubmed publisher
    ..Accordingly, NMDA-induced internalization of the AMPA receptor subunit GluA1 was impaired in LRP1-deficient neurons...
  49. Hashimoto K, Fukaya M, Qiao X, Sakimura K, Watanabe M, Kano M. Impairment of AMPA receptor function in cerebellar granule cells of ataxic mutant mouse stargazer. J Neurosci. 1999;19:6027-36 pubmed
    ..These results suggest that the defect in MF to GC synaptic transmission is a major factor that causes the cerebellar dysfunction in the stg mutant mouse. ..
  50. Zamanillo D, Sprengel R, Hvalby O, Jensen V, Burnashev N, Rozov A, et al. Importance of AMPA receptors for hippocampal synaptic plasticity but not for spatial learning. Science. 1999;284:1805-11 pubmed
    ..The results suggest that CA1 hippocampal LTP is controlled by the number or subunit composition of AMPA receptors and show a dichotomy between LTP in CA1 and acquisition of spatial memory. ..
  51. Delgado J, Coba M, Anderson C, Thompson K, Gray E, Heusner C, et al. NMDA receptor activation dephosphorylates AMPA receptor glutamate receptor 1 subunits at threonine 840. J Neurosci. 2007;27:13210-21 pubmed
    ..Although three previously identified phosphorylation sites in AMPA receptor glutamate receptor 1 (GluR1) subunits (S818, S831, and S845) appear to have important roles in LTP and LTD, little is known ..
  52. Hoffman D, Sprengel R, Sakmann B. Molecular dissection of hippocampal theta-burst pairing potentiation. Proc Natl Acad Sci U S A. 2002;99:7740-5 pubmed
    ..The two components of synaptic potentiation could be relevant for different forms of information storage that are dependent on hippocampal synaptic transmission such as spatial reference and working memory. ..
  53. Andrasfalvy B, Smith M, Borchardt T, Sprengel R, Magee J. Impaired regulation of synaptic strength in hippocampal neurons from GluR1-deficient mice. J Physiol. 2003;552:35-45 pubmed
    ..In fact, glutamate receptor 1 (GluR1 or GluRA) subunits containing L-alpha-amino-3-hydroxy-5-methylisoxazole-4-propionate (AMPA) ..
  54. Mead A, Brown G, Le Merrer J, Stephens D. Effects of deletion of gria1 or gria2 genes encoding glutamatergic AMPA-receptor subunits on place preference conditioning in mice. Psychopharmacology (Berl). 2005;179:164-71 pubmed
    ..of cocaine and food to induce a CPP in mice lacking either the GluR1 or GluR2 subunits of the AMPA receptor [gria1 or gria2 knockout (KO) mice]...
  55. Jensen V, Kaiser K, Borchardt T, Adelmann G, Rozov A, Burnashev N, et al. A juvenile form of postsynaptic hippocampal long-term potentiation in mice deficient for the AMPA receptor subunit GluR-A. J Physiol. 2003;553:843-56 pubmed
    ..Our results show that in the developing hippocampus synaptic plasticity can be expressed by AMPA receptors lacking the GluR-A subunit. ..
  56. Sanderson D, Good M, Skelton K, Sprengel R, Seeburg P, Rawlins J, et al. Enhanced long-term and impaired short-term spatial memory in GluA1 AMPA receptor subunit knockout mice: evidence for a dual-process memory model. Learn Mem. 2009;16:379-86 pubmed publisher
    The GluA1 AMPA receptor subunit is a key mediator of hippocampal synaptic plasticity and is especially important for a rapidly-induced, short-lasting form of potentiation...
  57. Hartmann B, Ahmadi S, Heppenstall P, Lewin G, Schott C, Borchardt T, et al. The AMPA receptor subunits GluR-A and GluR-B reciprocally modulate spinal synaptic plasticity and inflammatory pain. Neuron. 2004;44:637-50 pubmed
  58. Patriarchi T, Amabile S, Frullanti E, Landucci E, Lo Rizzo C, Ariani F, et al. Imbalance of excitatory/inhibitory synaptic protein expression in iPSC-derived neurons from FOXG1(+/-) patients and in foxg1(+/-) mice. Eur J Hum Genet. 2016;24:871-80 pubmed publisher
    ..GAD67 and GABA AR-α1) were increased, whereas the levels of a number of excitatory synaptic markers (VGLUT1, GluA1, GluN1 and PSD-95) were decreased...
  59. Sanderson D, Bannerman D. The role of habituation in hippocampus-dependent spatial working memory tasks: evidence from GluA1 AMPA receptor subunit knockout mice. Hippocampus. 2012;22:981-94 pubmed publisher
    ..In this review, we describe work with GluA1 AMPA receptor subunit knockout mice that show impaired spatial alternation, but normal spatial reference memory...
  60. Nikolova G, Sinsheimer J, Eicher E, Vilain E. The chromosome 11 region from strain 129 provides protection from sex reversal in XYPOS mice. Genetics. 2008;179:419-27 pubmed publisher
    ..We conclude that a chromosome 11 locus derived from 129Sl/SvImJ essentially protects against sex reversal in XYPOS mice. A number of genes located in this chromosome 11 region are discussed as potential candidates. ..
  61. Lane D, Jaferi A, Kreek M, Pickel V. Acute and chronic cocaine differentially alter the subcellular distribution of AMPA GluR1 subunits in region-specific neurons within the mouse ventral tegmental area. Neuroscience. 2010;169:559-73 pubmed publisher
    Cocaine administration increases AMPA GluR1 expression and receptor-mediated activation of the ventral tegmental area (VTA)...
  62. Gerges N, Backos D, Rupasinghe C, Spaller M, Esteban J. Dual role of the exocyst in AMPA receptor targeting and insertion into the postsynaptic membrane. EMBO J. 2006;25:1623-34 pubmed
    ..Therefore, we propose a molecular and anatomical model that dissects AMPA receptor sorting and synaptic delivery within the spine, and uncovers new functions of the exocyst at the postsynaptic membrane. ..
  63. Makino Y, Johnson R, Yu Y, Takamiya K, Huganir R. Enhanced synaptic plasticity in mice with phosphomimetic mutation of the GluA1 AMPA receptor. Proc Natl Acad Sci U S A. 2011;108:8450-5 pubmed publisher
    Phosphorylation of the GluA1 subunit of AMPA receptors has been proposed to regulate receptor trafficking and synaptic transmission and plasticity...
  64. Feyder M, Wiedholz L, Sprengel R, Holmes A. Impaired associative fear learning in mice with complete loss or haploinsufficiency of AMPA GluR1 receptors. Front Behav Neurosci. 2007;1:4 pubmed publisher
    ..evidence that l-alpha-amino-3-hydroxy-5-methylisoxazole-4-propionate (AMPA) glutamate receptors containing the GluR1 subunit contribute to the molecular mechanisms associated with learning...
  65. Aitta Aho T, Vekovischeva O, Neuvonen P, Korpi E. Reduced benzodiazepine tolerance, but increased flumazenil-precipitated withdrawal in AMPA-receptor GluR-A subunit-deficient mice. Pharmacol Biochem Behav. 2009;92:283-90 pubmed publisher
    ..c.) 48 h after discontinuation of the flurazepam treatment, were enhanced in the GluR-A-/- mice. The results stress the importance of the AMPA-receptor system in neuroadaptation to acute and chronic effects of benzodiazepines. ..
  66. Shimshek D, Bus T, Schupp B, Jensen V, Marx V, Layer L, et al. Different Forms of AMPA Receptor Mediated LTP and Their Correlation to the Spatial Working Memory Formation. Front Mol Neurosci. 2017;10:214 pubmed publisher
    ..CA3/CA1 synapses are dependent on L-?-amino-3-hydroxy-5-methylisoxazole-4-propionate receptors (AMPARs) containing GluA1 subunits as demonstrated by knockout mice lacking GluA1...
  67. Liu J, Conde K, Zhang P, Lilascharoen V, Xu Z, Lim B, et al. Enhanced AMPA Receptor Trafficking Mediates the Anorexigenic Effect of Endogenous Glucagon-like Peptide-1 in the Paraventricular Hypothalamus. Neuron. 2017;96:897-909.e5 pubmed publisher
    ..promoting a protein kinase A (PKA)-dependent signaling cascade leading to phosphorylation of serine S845 on GluA1 AMPA receptors and their trafficking to the plasma membrane...