granzyme K

Summary

Gene Symbol: granzyme K
Description: granzyme K
Alias: granzyme K
Species: mouse
Products:     granzyme K

Top Publications

  1. Zhao T, Zhang H, Guo Y, Fan Z. Granzyme K directly processes bid to release cytochrome c and endonuclease G leading to mitochondria-dependent cell death. J Biol Chem. 2007;282:12104-11 pubmed
    ..Little is known about how granzyme K functions in killer lymphocyte-mediated cytolysis...
  2. Suemoto T, Taniguchi M, Shiosaka S, Yoshida S. cDNA cloning and expression of a novel serine protease in the mouse brain. Brain Res Mol Brain Res. 1999;70:273-81 pubmed
    A cDNA for a novel serine protease, termed brain type granzyme K (B-GRK) was cloned from the mouse brain. The cDNA codes a protein similar to granzyme K (GRK) but completely different at the N-terminus...
  3. Kondaurova E, Naumenko V, Sinyakova N, Kulikov A. Map3k1, Il6st, Gzmk, and Hspb3 gene coexpression network in the mechanism of freezing reaction in mice. J Neurosci Res. 2011;89:267-73 pubmed publisher
    ..CBA-D13M76C by factor 1. It was suggested that a high predisposition to catalepsy in mice can be defined by the Map3k1, Il6st, Gzmk, and Hspb3 genes' coexpression network. ..
  4. Zhong C, Li C, Wang X, Toyoda T, Gao G, Fan Z. Granzyme K inhibits replication of influenza virus through cleaving the nuclear transport complex importin ?1/? dimer of infected host cells. Cell Death Differ. 2012;19:882-90 pubmed publisher
    ..Proteolysis of these two substrates wrecked their association to generate the importin ?1/? dimer and disrupted transportation of viral NP to the nucleus, leading to inhibition of influenza virus replication. ..
  5. Wensink A, Kemp V, Fermie J, Garcia Laorden M, van der Poll T, Hack C, et al. Granzyme K synergistically potentiates LPS-induced cytokine responses in human monocytes. Proc Natl Acad Sci U S A. 2014;111:5974-9 pubmed publisher
    ..However, the function of extracellular granzymes in inflammation largely remains unknown. Here, we show that granzyme K (GrK) binds to Gram-negative bacteria and their cell-wall component lipopolysaccharide (LPS)...
  6. Plasman K, Demol H, Bird P, Gevaert K, Van Damme P. Substrate specificities of the granzyme tryptases A and K. J Proteome Res. 2014;13:6067-77 pubmed publisher
    ..In addition, the so far uncharacterized mouse granzyme K was profiled alongside its human orthologue...
  7. Wilharm E, Tschopp J, Jenne D. Biological activities of granzyme K are conserved in the mouse and account for residual Z-Lys-SBzl activity in granzyme A-deficient mice. FEBS Lett. 1999;459:139-42 pubmed
    ..Here we report the cloning and biochemical characterization of recombinant mouse granzyme K (GzmK)...
  8. Jenkins M, Trapani J, Doherty P, Turner S. Granzyme K expressing cytotoxic T lymphocytes protects against influenza virus in granzyme AB-/- mice. Viral Immunol. 2008;21:341-6 pubmed publisher
    ..This suggests that grzK plays an important role in CD8(+) T-cell cytotoxicity both in the presence and absence of grzA and B. ..
  9. Sewell W, Sparrow D, Smith A, Gonzalez D, Rappaport E, Dunwoodie S, et al. Cyclical expression of the Notch/Wnt regulator Nrarp requires modulation by Dll3 in somitogenesis. Dev Biol. 2009;329:400-9 pubmed publisher
    ..Towards identifying the role of Dll3 in regulating somitogenesis, Nrarp emerges as a potentially important regulator that requires Dll3 but not Lfng for normal function...

More Information

Publications12

  1. Joeckel L, Wallich R, Martin P, Sánchez Martínez D, Weber F, Martin S, et al. Mouse granzyme K has pro-inflammatory potential. Cell Death Differ. 2011;18:1112-9 pubmed publisher
    ..Together with the finding that IL-1Ra (Anakinra) treatment inhibits virus elimination but not generation of cytotoxic Tc cells in wt mice, the data suggest that Tc cells control LCMV through non-cytotoxic processes that involve gzmK. ..
  2. Shresta S, Goda P, Wesselschmidt R, Ley T. Residual cytotoxicity and granzyme K expression in granzyme A-deficient cytotoxic lymphocytes. J Biol Chem. 1997;272:20236-44 pubmed
    ..could potentially account for the residual cytotoxicity in granzyme A-deficient CTL, we cloned the murine granzyme K gene, which is linked to granzyme A in humans, and proved that it is also tightly linked with murine granzyme A...
  3. Hink Schauer C, Estebanez Perpina E, Wilharm E, Fuentes Prior P, Klinkert W, Bode W, et al. The 2.2-A crystal structure of human pro-granzyme K reveals a rigid zymogen with unusual features. J Biol Chem. 2002;277:50923-33 pubmed
    b>Granzyme K (GzmK) belongs to a family of trypsin-like serine proteases localized in electron dense cytoplasmic granules of activated natural killer and cytotoxic T-cells...