Gpx1

Summary

Gene Symbol: Gpx1
Description: glutathione peroxidase 1
Alias: AI195024, AL033363, CGPx, GPx-1, GSHPx-1, Gpx, glutathione peroxidase 1, cellular glutathione peroxidase, selenium-dependent glutathione peroxidase 1
Species: mouse
Products:     Gpx1

Top Publications

  1. de Haan J, Stefanovic N, Nikolic Paterson D, Scurr L, Croft K, Mori T, et al. Kidney expression of glutathione peroxidase-1 is not protective against streptozotocin-induced diabetic nephropathy. Am J Physiol Renal Physiol. 2005;289:F544-51 pubmed
    ..Glutathione peroxidase-1 (Gpx1) is an antioxidant enzyme that is highly expressed in the kidney and removes peroxides and peroxynitrite that can ..
  2. Esworthy R, Binder S, Doroshow J, Chu F. Microflora trigger colitis in mice deficient in selenium-dependent glutathione peroxidase and induce Gpx2 gene expression. Biol Chem. 2003;384:597-607 pubmed
    ..germ-free GPX-DKO mice developed severe acute colitis while their littermates with at least one wild-type Gpx1 or Gpx2 gene remained virtually symptom-free. Microflora also affected Gpx2 gene expression...
  3. Duong C, Seow H, Bozinovski S, Crack P, Anderson G, Vlahos R. Glutathione peroxidase-1 protects against cigarette smoke-induced lung inflammation in mice. Am J Physiol Lung Cell Mol Physiol. 2010;299:L425-33 pubmed publisher
    ..Glutathione peroxidase-1 (gpx-1) is a detoxifying enzyme that may protect lungs from such damage...
  4. de Haan J, Witting P, Stefanovic N, Pete J, Daskalakis M, Kola I, et al. Lack of the antioxidant glutathione peroxidase-1 does not increase atherosclerosis in C57BL/J6 mice fed a high-fat diet. J Lipid Res. 2006;47:1157-67 pubmed
    ..As glutathione peroxidase-1 (Gpx1) is an antioxidant enzyme that detoxifies lipid hydroperoxides, we tested the impact of Gpx1 deficiency on ..
  5. Lewis P, Stefanovic N, Pete J, Calkin A, Giunti S, Thallas Bonke V, et al. Lack of the antioxidant enzyme glutathione peroxidase-1 accelerates atherosclerosis in diabetic apolipoprotein E-deficient mice. Circulation. 2007;115:2178-87 pubmed
    Recent clinical studies have suggested a major protective role for the antioxidant enzyme glutathione peroxidase-1 (GPx1) in diabetes-associated atherosclerosis...
  6. Wong C, Bozinovski S, Hertzog P, Hickey M, Crack P. Absence of glutathione peroxidase-1 exacerbates cerebral ischemia-reperfusion injury by reducing post-ischemic microvascular perfusion. J Neurochem. 2008;107:241-52 pubmed publisher
    Mice deficient in the anti-oxidant enzyme glutathione peroxidase-1 (Gpx1) have a greater susceptibility to cerebral injury following a localized ischemic event...
  7. Chu F, Esworthy R, Chu P, Longmate J, Huycke M, Wilczynski S, et al. Bacteria-induced intestinal cancer in mice with disrupted Gpx1 and Gpx2 genes. Cancer Res. 2004;64:962-8 pubmed
    ..We have previously demonstrated that targeted disruption of both the Gpx1 and Gpx2 genes (GPX-DKO) results in a high incidence of ileocolitis in mice raised under conventional conditions, ..
  8. de Haan J, Crack P, Flentjar N, Iannello R, Hertzog P, Kola I. An imbalance in antioxidant defense affects cellular function: the pathophysiological consequences of a reduction in antioxidant defense in the glutathione peroxidase-1 (Gpx1) knockout mouse. Redox Rep. 2003;8:69-79 pubmed
    ..The investigations of Sod1 transgenic cell-lines and mice, as well as Gpx1 knockout mice (both models favor H(2)O(2) accumulation), are presented...
  9. Cheng W, Zheng X, Quimby F, Roneker C, Lei X. Low levels of glutathione peroxidase 1 activity in selenium-deficient mouse liver affect c-Jun N-terminal kinase activation and p53 phosphorylation on Ser-15 in pro-oxidant-induced aponecrosis. Biochem J. 2003;370:927-34 pubmed
    Low levels of hepatic selenium (Se)-dependent glutathione peroxidase 1 (GPX1) activity have been shown to protect against oxidative liver injury in Se-deficient mice...

More Information

Publications90

  1. Crack P, Taylor J, Flentjar N, de Haan J, Hertzog P, Iannello R, et al. Increased infarct size and exacerbated apoptosis in the glutathione peroxidase-1 (Gpx-1) knockout mouse brain in response to ischemia/reperfusion injury. J Neurochem. 2001;78:1389-99 pubmed
    ..Infarct volume was increased three-fold in the glutathione peroxidase-1 (Gpx-1) -/- mouse compared with the wild-type mouse; this was mirrored by an increase in the level of apoptosis found at ..
  2. Fu Y, Sies H, Lei X. Opposite roles of selenium-dependent glutathione peroxidase-1 in superoxide generator diquat- and peroxynitrite-induced apoptosis and signaling. J Biol Chem. 2001;276:43004-9 pubmed
    ..We determined impacts of a selenium-dependent glutathione peroxidase-1 (GPX1) on apoptosis induced by diquat (DQ), a ROS (superoxide) generator, and peroxynitrite (PN), a potent RNS...
  3. Chew P, Yuen D, Stefanovic N, Pete J, Coughlan M, Jandeleit Dahm K, et al. Antiatherosclerotic and renoprotective effects of ebselen in the diabetic apolipoprotein E/GPx1-double knockout mouse. Diabetes. 2010;59:3198-207 pubmed publisher
    To investigate the effect of the GPx1-mimetic ebselen on diabetes-associated atherosclerosis and renal injury in a model of increased oxidative stress.
  4. Ho Y, Magnenat J, Bronson R, Cao J, Gargano M, Sugawara M, et al. Mice deficient in cellular glutathione peroxidase develop normally and show no increased sensitivity to hyperoxia. J Biol Chem. 1997;272:16644-51 pubmed
    ..To further clarify the physiological relevance of this enzyme, a model of mice deficient in cellular glutathione peroxidase (GSHPx-1), the major isoform of glutathione peroxidase ubiquitously expressed in all types of cells, ..
  5. Mirochnitchenko O, Palnitkar U, Philbert M, Inouye M. Thermosensitive phenotype of transgenic mice overproducing human glutathione peroxidases. Proc Natl Acad Sci U S A. 1995;92:8120-4 pubmed
    ..GP transgenic mice provide a model for studying thermoregulation and processes involving actions of hydroxy and lipid peroxides in mammals. ..
  6. Knorpp T, Robinson S, Crack P, Dringen R. Glutathione peroxidase-1 contributes to the protection of glutamine synthetase in astrocytes during oxidative stress. J Neural Transm (Vienna). 2006;113:1145-55 pubmed
    ..astrocyte-rich primary cultures from the brains of wild-type and glutathione peroxidase-1 deficient mice (GPx1(-/-)) were exposed to a chronic hydrogen peroxide-generating system consisting of xanthine oxidase, hypoxanthine ..
  7. Torzewski M, Ochsenhirt V, Kleschyov A, Oelze M, Daiber A, Li H, et al. Deficiency of glutathione peroxidase-1 accelerates the progression of atherosclerosis in apolipoprotein E-deficient mice. Arterioscler Thromb Vasc Biol. 2007;27:850-7 pubmed
    ..After 24 weeks on Western-type diet, double-knockout mice (GPx-1(-/-)ApoE(-/-)) developed significantly more atherosclerosis than control apolipoprotein E-deficient mice...
  8. Won H, Sohn J, Min H, Lee K, Woo H, Ho Y, et al. Glutathione peroxidase 1 deficiency attenuates allergen-induced airway inflammation by suppressing Th2 and Th17 cell development. Antioxid Redox Signal. 2010;13:575-87 pubmed publisher
    ..oxygen species (ROS), including hydrogen peroxide and lipid peroxides, both of which are reduced by glutathione peroxidase 1 (GPx1)...
  9. Esworthy R, Aranda R, Martin M, Doroshow J, Binder S, Chu F. Mice with combined disruption of Gpx1 and Gpx2 genes have colitis. Am J Physiol Gastrointest Liver Physiol. 2001;281:G848-55 pubmed
    Glutathione peroxidase (GPX)-1 and gastrointestinal (GI) epithelium-specific GPX (GPX-GI), encoded by Gpx1 and Gpx2, provide most GPX activity in GI epithelium...
  10. Kim B, Esworthy R, Hahn M, Pfeifer G, Chu F. Expression of lactoperoxidase in differentiated mouse colon epithelial cells. Free Radic Biol Med. 2012;52:1569-76 pubmed publisher
    ..However, in B6 mice deficient in glutathione peroxidase (GPx)-1 and -2, GPx1/2-double-knockout (DKO), which had intestinal pathology, the colon Lpo mRNA levels increased 5- to 12-fold ..
  11. de Haan J, Bladier C, Griffiths P, Kelner M, O Shea R, Cheung N, et al. Mice with a homozygous null mutation for the most abundant glutathione peroxidase, Gpx1, show increased susceptibility to the oxidative stress-inducing agents paraquat and hydrogen peroxide. J Biol Chem. 1998;273:22528-36 pubmed
    ..However, some recent studies on Gpx1 knockout (-/-) mice have failed to show a role for Gpx1 under conditions of oxidative stress such as hyperbaric ..
  12. Johnson R, Ho Y, Yu D, Kuypers F, Ravindranath Y, Goyette G. The effects of disruption of genes for peroxiredoxin-2, glutathione peroxidase-1, and catalase on erythrocyte oxidative metabolism. Free Radic Biol Med. 2010;48:519-25 pubmed publisher
    ..Additional experiments with mice with disrupted catalase or glutathione peroxidase (Gpx1) genes showed that Gpx1 is the only erythrocyte enzyme that reduces organic peroxides...
  13. Fu Y, Porres J, Lei X. Comparative impacts of glutathione peroxidase-1 gene knockout on oxidative stress induced by reactive oxygen and nitrogen species in mouse hepatocytes. Biochem J. 2001;359:687-95 pubmed
    Selenium-dependent glutathione peroxidase-1 (GPX1) protects against reactive-oxygen-species (ROS)-induced oxidative stress in vivo, but its role in coping with reactive nitrogen species (RNS) is unclear...
  14. Dayal S, Brown K, Weydert C, Oberley L, Arning E, Bottiglieri T, et al. Deficiency of glutathione peroxidase-1 sensitizes hyperhomocysteinemic mice to endothelial dysfunction. Arterioscler Thromb Vasc Biol. 2002;22:1996-2002 pubmed
    We tested the hypothesis that deficiency of cellular glutathione peroxidase (GPx-1) enhances susceptibility to endothelial dysfunction in mice with moderate hyperhomocysteinemia...
  15. Esworthy R, Kim B, Larson G, Yip M, Smith D, Li M, et al. Colitis locus on chromosome 2 impacting the severity of early-onset disease in mice deficient in GPX1 and GPX2. Inflamm Bowel Dis. 2011;17:1373-86 pubmed publisher
    Genetic background has a profound effect on inflammatory bowel disease. The Gpx1 and Gpx2 double knockout (GPX1/2-DKO) mice on a mixed C57BL/6 (B6) and 129S1/SvimJ (129) background exhibit spontaneous ileocolitis...
  16. Ardanaz N, Yang X, Cifuentes M, Haurani M, Jackson K, Liao T, et al. Lack of glutathione peroxidase 1 accelerates cardiac-specific hypertrophy and dysfunction in angiotensin II hypertension. Hypertension. 2010;55:116-23 pubmed publisher
    b>Glutathione peroxidase 1 (Gpx1) plays an important role in cellular defense by converting hydrogen peroxide and organic hydroperoxides to nonreactive products, and Gpx1(-/-) mice, which are characterized by reduced tissue glutathione ..
  17. Hahn M, Hahn T, Lee D, Esworthy R, Kim B, Riggs A, et al. Methylation of polycomb target genes in intestinal cancer is mediated by inflammation. Cancer Res. 2008;68:10280-9 pubmed publisher
    ..Chronic infection and inflammation contribute to up to 25% of all cancers worldwide. Using glutathione peroxidase, Gpx1 and Gpx2, double knockout (Gpx1/2-KO) mice as a model of inflammatory bowel disease predisposing to intestinal ..
  18. Steven Esworthy R, Kim B, Wang Y, Gao Q, Doroshow J, Leto T, et al. The Gdac1 locus modifies spontaneous and Salmonella-induced colitis in mice deficient in either Gpx2 or Gpx1 gene. Free Radic Biol Med. 2013;65:1273-1283 pubmed publisher
    ..the Gdac1 (Gpx-deficiency-associated colitis 1) locus, which influences the severity of spontaneous colitis in Gpx1- and Gpx2-double-knockout (Gpx1/2-DKO) mice...
  19. Esworthy R, Mann J, Sam M, Chu F. Low glutathione peroxidase activity in Gpx1 knockout mice protects jejunum crypts from gamma-irradiation damage. Am J Physiol Gastrointest Liver Physiol. 2000;279:G426-36 pubmed
    b>Gpx1 knockout (KO) mice had a higher number of regenerating crypts in the jejunum than did Gpx2-KO or wild-type mice analyzed 4 days after > or =10 Gy gamma-irradiation...
  20. Zhu J, Zhang X, McClung J, Lei X. Impact of Cu, Zn-superoxide dismutase and Se-dependent glutathione peroxidase-1 knockouts on acetaminophen-induced cell death and related signaling in murine liver. Exp Biol Med (Maywood). 2006;231:1726-32 pubmed
    ..to compare the impacts of knockout of Cu, Zn-superoxide dismutase (SOD1) and Se-dependent glutathione peroxidase-1 (GPX1) on cell death and related signaling mediated by acetaminophen (APAP), a RNS inducer in liver...
  21. Seiler A, Schneider M, Forster H, Roth S, Wirth E, Culmsee C, et al. Glutathione peroxidase 4 senses and translates oxidative stress into 12/15-lipoxygenase dependent- and AIF-mediated cell death. Cell Metab. 2008;8:237-48 pubmed publisher
    ..Since oxidative stress is common in the etiology of many human disorders, the identified pathway reveals promising targets for future therapies. ..
  22. Ho Y, Magnenat J, Gargano M, Cao J. The nature of antioxidant defense mechanisms: a lesson from transgenic studies. Environ Health Perspect. 1998;106 Suppl 5:1219-28 pubmed
    ..Transgenic mice overexpressing three isoforms of superoxide dismutase, catalase, and the cellular glutathione peroxidase (GSHPx-1) in various tissues show an increased tolerance to ischemia-reperfusion heart and brain ..
  23. Johnson R, Goyette G, Ravindranath Y, Ho Y. Red cells from glutathione peroxidase-1-deficient mice have nearly normal defenses against exogenous peroxides. Blood. 2000;96:1985-8 pubmed
    ..Circulating erythrocytes from the GSHPx-1-deficient mice exhibited a slight reduction in membrane thiols, indicating that high exposure to peroxides might occur naturally in the circulation. (Blood. 2000;96:1985-1988) ..
  24. Bozinovski S, Seow H, Crack P, Anderson G, Vlahos R. Glutathione peroxidase-1 primes pro-inflammatory cytokine production after LPS challenge in vivo. PLoS ONE. 2012;7:e33172 pubmed publisher
    ..Glutathione peroxidase-1 (gpx-1) is an anti-oxidant enzyme that may protect lungs from such damage...
  25. Wang Q, Liu Z, Wang J, Wang H, Li A, Yang Y, et al. Glutathione peroxidase-1 is required for self-renewal of murine embryonic stem cells. Biochem Biophys Res Commun. 2014;448:454-60 pubmed publisher
    ..We found that the expression level of glutathione peroxidase-1 (GPx-1), an antioxidant enzyme, is dramatically decreased upon the differentiation...
  26. Beck M, Esworthy R, Ho Y, Chu F. Glutathione peroxidase protects mice from viral-induced myocarditis. FASEB J. 1998;12:1143-9 pubmed
    b>Glutathione peroxidase 1 (GPX-1) is a selenium-dependent enzyme with antioxidant properties...
  27. Liddell J, Dringen R, Crack P, Robinson S. Glutathione peroxidase 1 and a high cellular glutathione concentration are essential for effective organic hydroperoxide detoxification in astrocytes. Glia. 2006;54:873-9 pubmed
    ..To examine the contribution of glutathione peroxidase-1 (GPx1) and glutathione (GSH) in the disposal of organic hydroperoxides in brain astrocytes, primary astrocyte cultures ..
  28. Franke K, Curth K, Lenart J, Knochenhauer D, Kietzmann T. Enhanced plasminogen activator inhibitor-1 expression in transgenic mice with hepatocyte-specific overexpression of superoxide dismutase or glutathione peroxidase. Antioxid Redox Signal. 2004;6:721-8 pubmed
    ..expression of the redox-modifying enzymes copper/zinc superoxide dismutase (SOD) and glutathione peroxidase (GPX) by using a tetracycline-regulatable gene expression system...
  29. Lim C, Bryan N, Jain M, Garcia Saura M, Fernandez B, Sawyer D, et al. Glutathione peroxidase deficiency exacerbates ischemia-reperfusion injury in male but not female myocardium: insights into antioxidant compensatory mechanisms. Am J Physiol Heart Circ Physiol. 2009;297:H2144-53 pubmed publisher
    ..Previous studies have shown an important role of cellular glutathione peroxidase (GPx1) in protection of the myocardium from I/R injury...
  30. Forgione M, Weiss N, Heydrick S, Cap A, Klings E, Bierl C, et al. Cellular glutathione peroxidase deficiency and endothelial dysfunction. Am J Physiol Heart Circ Physiol. 2002;282:H1255-61 pubmed
    b>Cellular glutathione peroxidase (GPx-1) is the most abundant intracellular isoform of the GPx antioxidant enzyme family...
  31. Nguyen A, Duquette N, Mamarbachi M, Thorin E. Epigenetic Regulatory Effect of Exercise on Glutathione Peroxidase 1 Expression in the Skeletal Muscle of Severely Dyslipidemic Mice. PLoS ONE. 2016;11:e0151526 pubmed publisher
    ..reported that exercise can induce changes in the expression of antioxidant enzymes including Sod2, Trx1, Prdx3 and Gpx1 and limits the rise in oxidative stress commonly associated with CVD...
  32. Tan S, Sharma A, Yuen D, Stefanovic N, Krippner G, Mugesh G, et al. The modified selenenyl amide, M-hydroxy ebselen, attenuates diabetic nephropathy and diabetes-associated atherosclerosis in ApoE/GPx1 double knockout mice. PLoS ONE. 2013;8:e69193 pubmed publisher
    ..Consequently, we investigated the effects of ME in an in vivo model of diabetes, the ApoE/GPx1 double knockout (dKO) mouse...
  33. Wang R, Islam B, Bridges A, Sharman S, Hu M, Hou Y, et al. cGMP Signaling Increases Antioxidant Gene Expression by Activating Forkhead Box O3A in the Colon Epithelium. Am J Pathol. 2017;187:377-389 pubmed publisher
    ..Moreover, this pathway is regulated by endogenous cGMP/PKG2 signaling, and can be targeted using phosphodiesterase-5 inhibitors. ..
  34. Kingsley P, Whitin J, Cohen H, Palis J. Developmental expression of extracellular glutathione peroxidase suggests antioxidant roles in deciduum, visceral yolk sac, and skin. Mol Reprod Dev. 1998;49:343-55 pubmed
    ..These findings suggest that EGPx may serve a wider antioxidant role than previously recognized in the interstitium of multiple localized tissues, particularly those associated with the active transport of lipids. ..
  35. Jiang D, Akopian G, Ho Y, Walsh J, Andersen J. Chronic brain oxidation in a glutathione peroxidase knockout mouse model results in increased resistance to induced epileptic seizures. Exp Neurol. 2000;164:257-68 pubmed
  36. Schnabel D, Salas Vidal E, Narvaez V, Sánchez Carbente M, Hernández García D, Cuervo R, et al. Expression and regulation of antioxidant enzymes in the developing limb support a function of ROS in interdigital cell death. Dev Biol. 2006;291:291-9 pubmed
    ..Even more inhibition of glutathione peroxidase activity leads to cell death in the digits, suggesting that a decrease in antioxidant activity, likely due to Gpx4, caused an increase in ROS levels, thus triggering apoptosis. ..
  37. Cheng W, Ho Y, Ross D, Han Y, Combs G, Lei X. Overexpression of cellular glutathione peroxidase does not affect expression of plasma glutathione peroxidase or phospholipid hydroperoxide glutathione peroxidase in mice offered diets adequate or deficient in selenium. J Nutr. 1997;127:675-80 pubmed
    Selenium-dependent cellular glutathione peroxidase (GPX1) overexpressing [GPX1(+)] mice were derived by microinjecting a 5.3-kb cloned entire mouse GPX1 genomic DNA into fertilized eggs...
  38. Baek I, Yon J, Lee B, Yun Y, Yu W, Hong J, et al. Expression pattern of cytosolic glutathione peroxidase (cGPx) mRNA during mouse embryogenesis. Anat Embryol (Berl). 2005;209:315-21 pubmed
    The selenoprotein cytosolic glutathione peroxidase (cGPx) is ubiquitously distributed in a variety of organs, and its primary function is to protect oxidative damage...
  39. de Haan J, Newman J, Kola I. Cu/Zn superoxide dismutase mRNA and enzyme activity, and susceptibility to lipid peroxidation, increases with aging in murine brains. Brain Res Mol Brain Res. 1992;13:179-87 pubmed
    ..In this study, we investigate the expression of Sod1, Gpx1 and susceptibility to lipid peroxidation during the aging process in mouse brains...
  40. Ishibashi N, Prokopenko O, Reuhl K, Mirochnitchenko O. Inflammatory response and glutathione peroxidase in a model of stroke. J Immunol. 2002;168:1926-33 pubmed
  41. Dikiy A, Novoselov S, Fomenko D, Sengupta A, Carlson B, Cerny R, et al. SelT, SelW, SelH, and Rdx12: genomics and molecular insights into the functions of selenoproteins of a novel thioredoxin-like family. Biochemistry. 2007;46:6871-82 pubmed
    ..Rdx12 was found to interact with glutathione peroxidase 1, whereas 14-3-3 protein was identified as one of the targets of mammalian SelW, suggesting a mechanism ..
  42. Gurzov E, Tran M, Fernandez Rojo M, Merry T, Zhang X, Xu Y, et al. Hepatic oxidative stress promotes insulin-STAT-5 signaling and obesity by inactivating protein tyrosine phosphatase N2. Cell Metab. 2014;20:85-102 pubmed publisher
    ..Our studies define a mechanism for the development of selective insulin resistance with wide-ranging implications for diseases characterized by oxidative stress. ..
  43. Lee D, Son D, Park M, Yoon D, Han S, Hong J. Glutathione peroxidase 1 deficiency attenuates concanavalin A-induced hepatic injury by modulation of T-cell activation. Cell Death Dis. 2016;7:e2208 pubmed publisher
    ..Because glutathione peroxidase 1 (Gpx1) is an antioxidant enzyme and is involved in T-cell development, we investigated the role of Gpx1 ..
  44. Wang S, Weaver J, Zhang S, Lei X. Knockout of SOD1 promotes conversion of selenocysteine to dehydroalanine in murine hepatic GPX1 protein. Free Radic Biol Med. 2011;51:197-204 pubmed publisher
    Se-dependent glutathione peroxidase-1 (GPX1) and Cu,Zn-superoxide dismutase (SOD1) are two major intracellular antioxidant enzymes...
  45. Cheng F, Torzewski M, Degreif A, Rossmann H, Canisius A, Lackner K. Impact of glutathione peroxidase-1 deficiency on macrophage foam cell formation and proliferation: implications for atherogenesis. PLoS ONE. 2013;8:e72063 pubmed publisher
    Clinical and experimental evidence suggests a protective role for the antioxidant enzyme glutathione peroxidase-1 (GPx-1) in the atherogenic process...
  46. Hill K, Wu S, Motley A, Stevenson T, Winfrey V, Capecchi M, et al. Production of selenoprotein P (Sepp1) by hepatocytes is central to selenium homeostasis. J Biol Chem. 2012;287:40414-24 pubmed publisher
    ..selenium deficiency down-regulated the mRNA of the most abundant hepatic selenoprotein, glutathione peroxidase-1 (Gpx1), to 15% of the selenium-replete value, while reducing Sepp1 mRNA, the most abundant hepatic selenoprotein mRNA, ..
  47. Taylor J, Ali U, Iannello R, Hertzog P, Crack P. Diminished Akt phosphorylation in neurons lacking glutathione peroxidase-1 (Gpx1) leads to increased susceptibility to oxidative stress-induced cell death. J Neurochem. 2005;92:283-93 pubmed
    We have previously identified an increased susceptibility of glutathione peroxidase-1 (Gpx1)-/- mice to neuronal apoptosis following mid-cerebral artery (MCA) occlusion...
  48. Han C, Someya S. Mouse models of age-related mitochondrial neurosensory hearing loss. Mol Cell Neurosci. 2013;55:95-100 pubmed publisher
    ..This article is part of a Special Issue entitled 'Mitochondrial function and dysfunction in neurodegeneration'. ..
  49. Kim H, Lee A, Choi E, Hong M, Kie J, Lim W, et al. Reactive oxygen species prevent imiquimod-induced psoriatic dermatitis through enhancing regulatory T cell function. PLoS ONE. 2014;9:e91146 pubmed publisher
    ..Taken together, it was implied that appropriately elevated levels of ROS might prevent psoriasis through enhancing IDO expression and Treg function. ..
  50. Oelze M, Kröller Schön S, Steven S, Lubos E, Doppler C, Hausding M, et al. Glutathione peroxidase-1 deficiency potentiates dysregulatory modifications of endothelial nitric oxide synthase and vascular dysfunction in aging. Hypertension. 2014;63:390-6 pubmed publisher
    ..to investigate the extent of vascular dysfunction and oxidant formation in glutathione peroxidase-1-deficient (GPx-1(-/-)) mice during the aging process with special emphasis on dysregulation (uncoupling) of the endothelial NO ..
  51. Rederstorff M, Castets P, Arbogast S, Laine J, Vassilopoulos S, Beuvin M, et al. Increased muscle stress-sensitivity induced by selenoprotein N inactivation in mouse: a mammalian model for SEPN1-related myopathy. PLoS ONE. 2011;6:e23094 pubmed publisher
  52. Furling D, Ghribi O, Lahsaini A, Mirault M, Massicotte G. Impairment of synaptic transmission by transient hypoxia in hippocampal slices: improved recovery in glutathione peroxidase transgenic mice. Proc Natl Acad Sci U S A. 2000;97:4351-6 pubmed
    ..In this study, we investigated in transgenic (Tg) mice whether a moderate increase in glutathione peroxidase-1 (GPx1) may improve the capacity of CA1 pyramidal cells to recover synaptic transmission after a short period of hypoxia ..
  53. Walshe J, Serewko Auret M, Teakle N, Cameron S, Minto K, Smith L, et al. Inactivation of glutathione peroxidase activity contributes to UV-induced squamous cell carcinoma formation. Cancer Res. 2007;67:4751-8 pubmed
    ..This was tested in Gpx1(-/-) and Gpx2(-/-) mice exposed to solar-simulated UV radiation...
  54. Lien Y, Feinstein S, Dodia C, Fisher A. The roles of peroxidase and phospholipase A2 activities of peroxiredoxin 6 in protecting pulmonary microvascular endothelial cells against peroxidative stress. Antioxid Redox Signal. 2012;16:440-51 pubmed publisher
  55. Zhu J, Lei X. Double null of selenium-glutathione peroxidase-1 and copper, zinc-superoxide dismutase enhances resistance of mouse primary hepatocytes to acetaminophen toxicity. Exp Biol Med (Maywood). 2006;231:545-52 pubmed
    This study was conducted to determine the impact of knockout of selenium (Se)-dependent glutathione peroxidase-1 (GPX1-/-) or double knockout of GPX1 and copper, zinc (Cu,Zn)-super-oxide dismutase (SOD1) on cell death induced by ..
  56. Spector A, Kuszak J, Ma W, Wang R. The effect of aging on glutathione peroxidase-i knockout mice-resistance of the lens to oxidative stress. Exp Eye Res. 2001;72:533-45 pubmed
    Populations of control, C, and glutathione peroxidase-1 (GPx-1) knockout mice, K, were studied over a period of 2 years...
  57. Chambers I, Frampton J, Goldfarb P, Affara N, McBain W, Harrison P. The structure of the mouse glutathione peroxidase gene: the selenocysteine in the active site is encoded by the 'termination' codon, TGA. EMBO J. 1986;5:1221-7 pubmed
  58. Van Remmen H, Qi W, Sabia M, Freeman G, Estlack L, Yang H, et al. Multiple deficiencies in antioxidant enzymes in mice result in a compound increase in sensitivity to oxidative stress. Free Radic Biol Med. 2004;36:1625-34 pubmed
    ..we have generated mice (Sod2(+/-)/Gpx1(-/-)) that are deficient in Mn superoxide dismutase (MnSOD) and glutathione peroxidase 1 (Gpx1) by breeding Sod2(+/-) and Gpx1(-/-) mice together...
  59. Schwaab V, Baud E, Ghyselinck N, Mattei M, Dufaure J, Drevet J. Cloning of the mouse gene encoding plasma glutathione peroxidase: organization, sequence and chromosomal localization. Gene. 1995;167:25-31 pubmed
    ..strategy, with degenerated primers localized in highly conserved domains of known glutathione peroxidase (GPX) proteins, we have generated, from mouse epididymal RNA, a cDNA fragment which was subsequently used to isolate a ..
  60. Bensadoun J, Mirochnitchenko O, Inouye M, Aebischer P, Zurn A. Attenuation of 6-OHDA-induced neurotoxicity in glutathione peroxidase transgenic mice. Eur J Neurosci. 1998;10:3231-6 pubmed
    ..2% and 56.5%, respectively. Overexpression of glutathione peroxidase therefore partially protects dopaminergic neurons against 6-hydroxydopamine-induced toxicity. ..
  61. Wang J, Silva J, Gustafsson C, Rustin P, Larsson N. Increased in vivo apoptosis in cells lacking mitochondrial DNA gene expression. Proc Natl Acad Sci U S A. 2001;98:4038-43 pubmed
    ..It would therefore be of interest to determine whether manipulation of respiratory chain function can be used to inhibit or enhance apoptosis in these conditions. ..
  62. Yang W, Park S, Ji S, Kang J, Kim J, Song H, et al. O-GlcNAcylation regulates hyperglycemia-induced GPX1 activation. Biochem Biophys Res Commun. 2010;391:756-61 pubmed publisher
    Hyperglycemia induces activation of glutathione peroxidase 1 (GPX1), an anti-oxidant enzyme essential for cell survival during oxidative stress. However, the mechanism of GPX1 activation is unclear...
  63. Yun J, Lum K, Lei X. A novel upregulation of glutathione peroxidase 1 by knockout of liver-regenerating protein Reg3? aggravates acetaminophen-induced hepatic protein nitration. Free Radic Biol Med. 2013;65:291-300 pubmed publisher
    ..depletion of the peroxynitrite (ONOO(-)) scavenger glutathione by an upregulated hepatic glutathione peroxidase-1 (GPX1) activity. The enhanced GPX1 production in the KO mice was mediated by an 85% rise (p<0...
  64. Lee S, Shin H, Shireman P, Vasilaki A, Van Remmen H, Csete M. Glutathione-peroxidase-1 null muscle progenitor cells are globally defective. Free Radic Biol Med. 2006;41:1174-84 pubmed
    Mice lacking glutathione peroxidase-1 (Gpx1) have decreased resistance to systemically administered oxidants as well as infections, and sustain increased damage after ischemia-reperfusion injuries...
  65. Geraghty P, Hardigan A, Wallace A, Mirochnitchenko O, Thankachen J, Arellanos L, et al. The glutathione peroxidase 1-protein tyrosine phosphatase 1B-protein phosphatase 2A axis. A key determinant of airway inflammation and alveolar destruction. Am J Respir Cell Mol Biol. 2013;49:721-30 pubmed publisher
    ..This study aimed to identify how the interaction between the intracellular antioxidant glutathione peroxidase-1 (GPx-1) and PTP1B affected lung PP2A activity and airway inflammation...
  66. Esworthy R, Kim B, Rivas G, Leto T, Doroshow J, Chu F. Analysis of candidate colitis genes in the Gdac1 locus of mice deficient in glutathione peroxidase-1 and -2. PLoS ONE. 2012;7:e44262 pubmed publisher
    Mice that are deficient for glutathione peroxidases 1 and 2 (GPX) show large variations in the penetrance and severity of colitis in C57BL/6J and 129S1/SvImJ backgrounds...
  67. Nam S, Nakamuta N, Kurohmaru M, Hayashi Y. Cloning and sequencing of the mouse cDNA encoding a phospholipid hydroperoxide glutathione peroxidase. Gene. 1997;198:245-9 pubmed
    ..4%), human (92.9%), and rat (98%) PHGPxs. However, the PHGPx mRNA particularly showed a high degree of expression in testis. This suggests that the PHGPx in testis may have more than just an antioxidant function. ..
  68. Carr W, Oberley Deegan R, Zhang Y, Oberley C, Oberley L, Dunnwald M. Antioxidant proteins and reactive oxygen species are decreased in a murine epidermal side population with stem cell-like characteristics. Histochem Cell Biol. 2011;135:293-304 pubmed publisher
    ..of neonatal cutaneous sections revealed that antioxidant enzymes [catalase, SOD2, gluthatione peroxidase-1 (GPx)] and ROS are localized predominantly to the epidermis...
  69. Linares M, Marín García P, Martínez Chacón G, Pérez Benavente S, Puyet A, Diez A, et al. Glutathione peroxidase contributes with heme oxygenase-1 to redox balance in mouse brain during the course of cerebral malaria. Biochim Biophys Acta. 2013;1832:2009-18 pubmed publisher
    ..Our findings reconcile the apparent inconsistency between the lack of oxidative metabolite build up and reported protective effect of antioxidant therapy against CM. ..
  70. Chittum H, Baek H, Diamond A, Fernandez Salguero P, Gonzalez F, Ohama T, et al. Selenocysteine tRNA[Ser]Sec levels and selenium-dependent glutathione peroxidase activity in mouse embryonic stem cells heterozygous for a targeted mutation in the tRNA[Ser]Sec gene. Biochemistry. 1997;36:8634-9 pubmed
    ..Sec tRNA population and determined the activity of the anti-oxidant, selenium-containing glutathione peroxidase (GPx) in the heterozygotes and in wild type cells grown in media with and without added selenium...
  71. Chen M, Wong C, Peng Z, Manikandan J, Melendez A, Tan T, et al. A global transcriptomic view of the multifaceted role of glutathione peroxidase-1 in cerebral ischemic-reperfusion injury. Free Radic Biol Med. 2011;50:736-48 pubmed publisher
    ..on the infarct cortex of wild-type (WT) and glutathione peroxidase-1 (a major antioxidant enzyme) knockout (Gpx1(-/-)) mice at 8 and 24h postreperfusion to identify differential gene expression profile patterns and potential ..
  72. Yu H, Hur J, Seo S, Moon H, Kim H, Park R, et al. Protective effect of ursolic acid from Cornus officinalis on the hydrogen peroxide-induced damage of HEI-OC1 auditory cells. Am J Chin Med. 2009;37:735-46 pubmed
    ..with ursolic acid significantly attenuated the decrease of activities of catalase (CAT) and glutathione peroxidase (GPX), but superoxide dismutase (SOD) activity was not significantly affected by ursolic acid...
  73. Modrick M, Didion S, Lynch C, Dayal S, Lentz S, Faraci F. Role of hydrogen peroxide and the impact of glutathione peroxidase-1 in regulation of cerebral vascular tone. J Cereb Blood Flow Metab. 2009;29:1130-7 pubmed publisher
    ..of our study was to use genetic approaches to examine the role of hydrogen peroxide (H2O2), glutathione peroxidase (Gpx1, which degrades H2O2), and CuZn-superoxide dismutase (SOD1, which produces H2O2 from superoxide) in mediating and ..
  74. Gosbell A, Stefanovic N, Scurr L, Pete J, Kola I, Favilla I, et al. Retinal light damage: structural and functional effects of the antioxidant glutathione peroxidase-1. Invest Ophthalmol Vis Sci. 2006;47:2613-22 pubmed
    The role of the antioxidant enzyme glutathione peroxidase-1 (GPx1) in protecting the retina against photo-oxidative damage was investigated in GPx1-deficient and wild-type mice...
  75. Flentjar N, Crack P, Boyd R, Malin M, de Haan J, Hertzog P, et al. Mice lacking glutathione peroxidase-1 activity show increased TUNEL staining and an accelerated inflammatory response in brain following a cold-induced injury. Exp Neurol. 2002;177:9-20 pubmed
  76. Wang X, Vatamaniuk M, Wang S, Roneker C, Simmons R, Lei X. Molecular mechanisms for hyperinsulinaemia induced by overproduction of selenium-dependent glutathione peroxidase-1 in mice. Diabetologia. 2008;51:1515-24 pubmed publisher
    ..Overproduction of the major antioxidant enzyme, glutathione peroxidase 1, caused seemingly beneficial changes in pancreatic PDX1 and UCP2, but eventually led to chronic ..
  77. Prows D, Hafertepen A, Winterberg A, Gibbons W, Liu C, Nick T. Genetic analysis of hyperoxic acute lung injury survival in reciprocal intercross mice. Physiol Genomics. 2007;30:271-81 pubmed
    ..QTL results confirmed that both parental strains contribute dominant resistance alleles to their offspring to determine individual HALI susceptibility. ..
  78. Tran T, Mai H, Shin E, Nam Y, Nguyen B, Lee Y, et al. Repeated exposure to far infrared ray attenuates acute restraint stress in mice via inhibition of JAK2/STAT3 signaling pathway by induction of glutathione peroxidase-1. Neurochem Int. 2016;94:9-22 pubmed publisher
    ..ARS elicited decreases in GSH/GSSG ratio, cytosolic Cu/Zn-superoxide dismutase (SOD-1), glutathione peroxidase (GPx), and glutathione reductase (GR) activities...
  79. Mai H, Chung Y, Shin E, Kim D, Jeong J, Nguyen T, et al. Genetic depletion of glutathione peroxidase-1 potentiates nephrotoxicity induced by multiple doses of cocaine via activation of angiotensin II AT1 receptor. Free Radic Res. 2016;50:467-83 pubmed publisher
    ..nuclear factor κB (NFκB) in renal damage caused by multiple doses of cocaine in glutathione peroxidase (GPx)-1 gene-depleted mice...
  80. Thiruchelvam M, Prokopenko O, Cory Slechta D, Richfield E, Buckley B, Mirochnitchenko O. Overexpression of superoxide dismutase or glutathione peroxidase protects against the paraquat + maneb-induced Parkinson disease phenotype. J Biol Chem. 2005;280:22530-9 pubmed
  81. Wolf N, Penn P, Pendergrass W, Van Remmen H, Bartke A, Rabinovitch P, et al. Age-related cataract progression in five mouse models for anti-oxidant protection or hormonal influence. Exp Eye Res. 2005;81:276-85 pubmed
    ..Model 1, mice null for the anti-oxidant gene glutathione peroxidase-1 (GPX1) had significantly advanced cataracts in older mice vs. same age controls...