Gene Symbol: Gpsm1
Description: G-protein signalling modulator 1 (AGS3-like, C. elegans)
Alias: 1810037C22Rik, AW107933, Ags3, G-protein-signaling modulator 1, activator of G-protein signaling 3
Species: mouse
Products:     Gpsm1

Top Publications

  1. Blumer J, Lord K, Saunders T, Pacchioni A, Black C, Lazartigues E, et al. Activator of G protein signaling 3 null mice: I. Unexpected alterations in metabolic and cardiovascular function. Endocrinology. 2008;149:3842-9 pubmed publisher
    ..As part of a broad effort to define the extent of functional diversity of AGS3-regulated-events in vivo, we generated AGS3 null mice...
  2. Singh V, Raghuwanshi S, Smith N, Rivers E, Richardson R. G Protein-coupled receptor kinase-6 interacts with activator of G protein signaling-3 to regulate CXCR2-mediated cellular functions. J Immunol. 2014;192:2186-94 pubmed publisher
    ..that, upon CXCR2 activation, GRK6 interacts with activator of G protein signaling (AGS)3 and G?i2 to form a GRK6/AGS3/G?i2 complex. This complex is time dependent and peaked at 2-3 min postactivation...
  3. Saadaoui M, Konno D, Loulier K, Goïame R, Jadhav V, Mapelli M, et al. Loss of the canonical spindle orientation function in the Pins/LGN homolog AGS3. EMBO Rep. 2017;18:1509-1520 pubmed publisher
    ..i>Drosophila Pins shares highly conserved functional domains with its two vertebrate homologs LGN and AGS3. Whereas the role of Pins and LGN in oriented divisions is extensively documented, involvement of AGS3 remains ..
  4. Peterson Y, Bernard M, Ma H, Hazard S, Graber S, Lanier S. Stabilization of the GDP-bound conformation of Gialpha by a peptide derived from the G-protein regulatory motif of AGS3. J Biol Chem. 2000;275:33193-6 pubmed
    The G-protein regulatory (GPR) motif in AGS3 was recently identified as a region for protein binding to heterotrimeric G-protein alpha subunits...
  5. Konno D, Shioi G, Shitamukai A, Mori A, Kiyonari H, Miyata T, et al. Neuroepithelial progenitors undergo LGN-dependent planar divisions to maintain self-renewability during mammalian neurogenesis. Nat Cell Biol. 2008;10:93-101 pubmed
    ..Our results suggest that planar mitosis ensures the self-renewal of neuroepithelial progenitors by one daughter inheriting both apical and basal compartments during neurogenesis. ..
  6. Regner K, Nozu K, Lanier S, Blumer J, Avner E, Sweeney W, et al. Loss of activator of G-protein signaling 3 impairs renal tubular regeneration following acute kidney injury in rodents. FASEB J. 2011;25:1844-55 pubmed publisher
    ..In this report, we demonstrate that activator of G-protein signaling 3 (AGS3), an unconventional receptor-independent regulator of heterotrimeric G-protein function, influences renal tubular ..
  7. Vural A, McQuiston T, Blumer J, Park C, Hwang I, Williams Bey Y, et al. Normal autophagic activity in macrophages from mice lacking G?i3, AGS3, or RGS19. PLoS ONE. 2013;8:e81886 pubmed publisher
    ..cells autophagy is modulated by a signaling pathway that employs G?i3, Activator of G-protein Signaling-3 (AGS3/GPSM1), and Regulator of G-protein Signaling 19 (RGS19)...
  8. Branham O Connor M, Robichaux W, Zhang X, Cho H, Kehrl J, Lanier S, et al. Defective chemokine signal integration in leukocytes lacking activator of G protein signaling 3 (AGS3). J Biol Chem. 2014;289:10738-47 pubmed publisher
    Activator of G-protein signaling 3 (AGS3, gene name G-protein signaling modulator-1, Gpsm1), an accessory protein for G-protein signaling, has functional roles in the kidney and CNS...
  9. Kaushik R, Yu F, Chia W, Yang X, Bahri S. Subcellular localization of LGN during mitosis: evidence for its cortical localization in mitotic cell culture systems and its requirement for normal cell cycle progression. Mol Biol Cell. 2003;14:3144-55 pubmed
    Mammalian LGN/AGS3 proteins and their Drosophila Pins orthologue are cytoplasmic regulators of G-protein signaling...

More Information


  1. Sanada K, Tsai L. G protein betagamma subunits and AGS3 control spindle orientation and asymmetric cell fate of cerebral cortical progenitors. Cell. 2005;122:119-31 pubmed
    ..Silencing AGS3, a nonreceptor activator of Gbetagamma, results in defects similar to the impairment of Gbetagamma, providing ..
  2. Kwon M, Pavlov T, Nozu K, Rasmussen S, Ilatovskaya D, Lerch Gaggl A, et al. G-protein signaling modulator 1 deficiency accelerates cystic disease in an orthologous mouse model of autosomal dominant polycystic kidney disease. Proc Natl Acad Sci U S A. 2012;109:21462-7 pubmed publisher
    ..In this study, we describe a functional role for the accessory protein, G-protein signaling modulator 1 (GPSM1), also known as activator of G-protein signaling 3, to act as a modulator of cyst progression in an orthologous ..
  3. Lacomme M, Tarchini B, Boudreau Pinsonneault C, Monat C, Cayouette M. The LGN protein promotes planar proliferative divisions in the neocortex but apicobasal asymmetric terminal divisions in the retina. Development. 2016;143:575-81 pubmed publisher
  4. Blumer J, Bernard M, Peterson Y, Nezu J, Chung P, Dunican D, et al. Interaction of activator of G-protein signaling 3 (AGS3) with LKB1, a serine/threonine kinase involved in cell polarity and cell cycle progression: phosphorylation of the G-protein regulatory (GPR) motif as a regulatory mechanism for the interaction . J Biol Chem. 2003;278:23217-20 pubmed
    Activator of G-protein signaling 3 (AGS3) has a modular domain structure consisting of seven tetratricopeptide repeats (TPRs) and four G-protein regulatory (GPR) motifs...
  5. Lamberti A, Sanges C, Chambery A, Migliaccio N, Rosso F, Di Maro A, et al. Analysis of interaction partners for eukaryotic translation elongation factor 1A M-domain by functional proteomics. Biochimie. 2011;93:1738-46 pubmed publisher
    ..Interestingly, a co-localization of SORBS2 and eEF1A was evidenced at level of plasma membrane, thus suggesting the involvement of eEF1A1 in novel key signal transduction complexes. ..
  6. Vural A, Al Khodor S, Cheung G, Shi C, Srinivasan L, McQuiston T, et al. Activator of G-Protein Signaling 3-Induced Lysosomal Biogenesis Limits Macrophage Intracellular Bacterial Infection. J Immunol. 2016;196:846-56 pubmed publisher
    ..In this article, we demonstrate that activator of G-protein signaling 3 (AGS3), an LPS-inducible protein in macrophages, affects both lysosomal biogenesis and activity...