Gene Symbol: Gpr88
Description: G-protein coupled receptor 88
Alias: AW061286, Strg, striatum-specific G-protein coupled receptor
Species: mouse
Products:     Gpr88

Top Publications

  1. Logue S, Grauer S, Paulsen J, Graf R, Taylor N, Sung M, et al. The orphan GPCR, GPR88, modulates function of the striatal dopamine system: a possible therapeutic target for psychiatric disorders?. Mol Cell Neurosci. 2009;42:438-47 pubmed publisher
    In rodents, the orphan G protein-coupled receptor, Gpr88, is highly expressed in brain regions implicated in the pathophysiology of and is modulated by treatments for schizophrenia...
  2. Beutler L, WANAT M, Quintana A, Sanz E, Bamford N, Zweifel L, et al. Balanced NMDA receptor activity in dopamine D1 receptor (D1R)- and D2R-expressing medium spiny neurons is required for amphetamine sensitization. Proc Natl Acad Sci U S A. 2011;108:4206-11 pubmed publisher
  3. Parker J, Beutler L, Palmiter R. The contribution of NMDA receptor signaling in the corticobasal ganglia reward network to appetitive Pavlovian learning. J Neurosci. 2011;31:11362-9 pubmed publisher
    ..Our findings suggest that NMDARs in neurons that project to and receive projections from the VTA are necessary for Pavlovian conditioning and specifically implicate the PFC and D(1)R-expressing MSNs in associative learning. ..
  4. Zhang K, Hill K, Labak S, Blatt G, Soghomonian J. Loss of glutamic acid decarboxylase (Gad67) in Gpr88-expressing neurons induces learning and social behavior deficits in mice. Neuroscience. 2014;275:238-47 pubmed publisher mice lacking the GABA-synthesizing enzyme glutamic acid decarboxylase, Gad67, in neurons expressing the protein Gpr88, an orphan G-protein-coupled receptor primarily expressed in the striatum...
  5. Naydenov A, Sepers M, Swinney K, Raymond L, Palmiter R, Stella N. Genetic rescue of CB1 receptors on medium spiny neurons prevents loss of excitatory striatal synapses but not motor impairment in HD mice. Neurobiol Dis. 2014;71:140-50 pubmed publisher
    ..We conclude that loss of excitatory striatal synapses in HD mice is controlled by CB1(MSN) and can be uncoupled from the motor phenotype. ..
  6. Meirsman A, Le Merrer J, Pellissier L, Diaz J, Clesse D, Kieffer B, et al. Mice Lacking GPR88 Show Motor Deficit, Improved Spatial Learning, and Low Anxiety Reversed by Delta Opioid Antagonist. Biol Psychiatry. 2016;79:917-27 pubmed publisher
    b>GPR88 is an orphan G protein coupled receptor highly enriched in the striatum, and previous studies have focused on GPR88 function in striatal physiology...
  7. Quintana A, Sanz E, Wang W, Storey G, Guler A, WANAT M, et al. Lack of GPR88 enhances medium spiny neuron activity and alters motor- and cue-dependent behaviors. Nat Neurosci. 2012;15:1547-55 pubmed publisher
    ..The orphan G protein-coupled receptor GPR88 is robustly expressed in MSNs and is regulated by neuropharmacological drugs, but its contribution to MSN ..
  8. Mizushima K, Miyamoto Y, Tsukahara F, Hirai M, Sakaki Y, Ito T. A novel G-protein-coupled receptor gene expressed in striatum. Genomics. 2000;69:314-21 pubmed
    ..revealed a novel striatum-specific transcript encoding an orphan G-protein-coupled receptor (GPCR) designated Strg/Gpr88 for striatum-specific GPCR...
  9. Lau J, Farzi A, Enriquez R, Shi Y, Herzog H. GPR88 is a critical regulator of feeding and body composition in mice. Sci Rep. 2017;7:9912 pubmed publisher
    b>GPR88 is an orphan G-protein-coupled receptor with predominant expression in reward-related areas in the brain...

More Information


  1. Zhang K, Chammas C, Soghomonian J. Loss of glutamic acid decarboxylase (Gad67) in striatal neurons expressing the Drdr1a dopamine receptor prevents L-DOPA-induced dyskinesia in 6-hydroxydopamine-lesioned mice. Neuroscience. 2015;303:586-94 pubmed publisher densely expressed in striatal direct pathway striatal neurons while the orphan G-protein-coupled receptor Gpr88 is densely expressed in striatal direct and indirect pathway striatal neurons, we used a cre-lox strategy to ..
  2. Meirsman A, Robe A, de Kerchove d Exaerde A, Kieffer B. GPR88 in A2AR Neurons Enhances Anxiety-Like Behaviors. Eneuro. 2016;3: pubmed publisher
    b>GPR88 is an orphan G-protein-coupled receptor highly expressed in striatal dopamine D1 (receptor) R- and D2R-expressing medium spiny neurons...
  3. Rainwater A, Sanz E, Palmiter R, Quintana A. Striatal GPR88 Modulates Foraging Efficiency. J Neurosci. 2017;37:7939-7947 pubmed publisher
    ..To investigate this function, we studied instrumental choice behavior in mice lacking GPR88, a striatum-enriched orphan G-protein-coupled receptor that modulates striatal medium spiny neuron excitability...